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Literature for peptidase T01.015: proteasome subunit beta5i

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, M Mutation, K Knockout, I Inhibitor, L Localization, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Albornoz,N., Alvarez-Indo,J., de la Pena,A., Arias-Munoz,E., Coca,A., Segovia-Miranda,F., Kerr,B., Budini,M., Criollo,A., Garcia-Robles,M.A., Morselli,E., Soza,A. and Burgos,P.V.
    Targeting the immunoproteasome in hypothalamic neurons as a novel therapeutic strategy for high-fat diet-induced obesity and metabolic dysregulation
    J Neuroinflammation21, 191-191. PubMed  Europe PubMed DOI
  2. Arai,Y., Shitama,H., Yamagishi,M., Ono,S., Kashima,A., Hiraizumi,M., Tsuda,N., Katayama,K., Tanaka,K., Koda,Y., Kato,S., Sakata,K., Nureki,O. and Miyazaki,H.
    Optimization of alpha-amido boronic acids via cryo-electron microscopy analysis: Discovery of a novel highly selective immunoproteasome subunit LMP7 (beta5i)/LMP2 (beta1i) dual inhibitor
    Bioorg Med Chem109, 117790-117790. PubMed  Europe PubMed DOI  I
    3. 2023
  3. Elhawary,N.A., Ekram,S.N., Abumansour,I.S., Azher,Z.A., AlJahdali,I.A., Alyamani,N.M., Naffadi,H.M., Sindi,I.A., Baazeem,A., Nassir,A.M. and Mufti,A.H.
    Sequence Variants in PSMB8/PSMB9 Immunoproteasome Genes and Risk of Urothelial Bladder Carcinoma
    Cureus15, e36293-e36293. PubMed  Europe PubMed DOI
  4. Li,J., Liu,N., Zhou,H., Xian,P., Song,Y., Tang,X., Li,Y. and Basler,M.
    Immunoproteasome inhibition prevents progression of castration-resistant prostate cancer
    Br J Cancer128, 1377-1390. PubMed  Europe PubMed DOI
  5. Li,J., Hu,S., Johnson,H.W.B., Kirk,C.J., Xian,P., Song,Y., Li,Y., Liu,N., Groettrup,M. and Basler,M.
    Co-inhibition of immunoproteasome subunits LMP2 and LMP7 enables prevention of transplant arteriosclerosis
    Cardiovasc Res119, 1030-1045. PubMed  Europe PubMed DOI
  6. Li,Y., Nan,G., Hou,X., Yan,Y., Yang,Y., Yang,Y., Li,K. and Xiao,Z.
    Non-peptidic immunoproteasome beta5i-selective inhibitor as potential treatment for idiopathic pulmonary fibrosis: Virtual screening, hit evolution and lead identification
    Eur J Med Chem261, 115856-115856. PubMed  Europe PubMed DOI  I
  7. Wang,M., Liu,Y., Dai,L., Zhong,X., Zhang,W., Xie,Y., Zeng,H. and Wang,H.
    ONX0914 inhibition of immunoproteasome subunit LMP7 ameliorates diabetic cardiomyopathy via restraining endothelial-mesenchymal transition
    Clin Sci (Lond)137, 1297-1309. PubMed  Europe PubMed DOI
    8. 2022
  8. Guo,T., Liu,C., Yang,C., Wu,J., Su,P. and Chen,J.
    Immunoproteasome subunit PSMB8 regulates microglia-mediated neuroinflammation upon manganese exposure by PERK signaling
    Food Chem Toxicol163, 112951-112951. PubMed  Europe PubMed DOI
    9. 2021
  9. Ah Kioon,M.D., Pierides,M., Pannellini,T., Lin,G., Nathan,C.F. and Barrat,F.J.
    Noncytotoxic Inhibition of the Immunoproteasome Regulates Human Immune Cells In Vitro and Suppresses Cutaneous Inflammation in the Mouse
    J Immunol206, 1631-1641. PubMed  Europe PubMed DOI  I
  10. El-Esawy,F.M., Abd El-Kareem,H.M., Mohamady,A.A., Agamy,A.M.M. and Salem,R.M.
    Proteasome Subunit Beta Type-8 (PSMB8) Gene Polymorphisms in Vitiligo: A Possible Predictor of Auditory Involvement
    J Clin Aesthet Dermatol14, 30-35. PubMed  Europe PubMed
  11. Kollar,L., Gobec,M., Szilagyi,B., Proj,M., Knez,D., Abranyi-Balogh,P., Petri,L., Imre,T., Bajusz,D., Ferenczy,G.G., Gobec,S., Keseru,G.M. and Sosic,I.
    Discovery of selective fragment-sized immunoproteasome inhibitors
    Eur J Med Chem219, 113455-113455. PubMed  Europe PubMed DOI
  12. Schiffrer,E.S., Proj,M., Gobec,M., Rejc,L., Sterman,A., Mravljak,J., Gobec,S. and Sosic,I.
    Synthesis and Biochemical Evaluation of Warhead-Decorated Psoralens as (Immuno)Proteasome Inhibitors
    Molecules26, PubMed  Europe PubMed DOI
  13. Sloot,W., Glaser,N., Hansen,A., Hellmann,J., Jaeckel,S., Johannes,S., Knippel,A., Lai,V. and Onidi,M.
    Improved nonclinical safety profile of a novel, highly selective inhibitor of the immunoproteasome subunit LMP7 (M3258)
    Toxicol Appl Pharmacol429, 115695-115695. PubMed  Europe PubMed DOI  I
    14. 2020
  14. Caputi,F.F., Di Cesare Mannelli,L., Rullo,L., Micheli,L., Stamatakos,S., Posa,L., Ghelardini,C., Romualdi,P. and Candeletti,S.
    The active second-generation proteasome inhibitor oprozomib reverts the oxaliplatin-induced neuropathy symptoms
    Biochem Pharmacol182, 114255-114255. PubMed  Europe PubMed DOI  I
  15. Chen,N.X., Liu,K., Liu,X., Zhang,X.X. and Han,D.Y.
    Induction and Regulation of the Immunoproteasome Subunit beta5i (PSMB8) in Laryngeal and Hypopharyngeal Carcinoma Cells
    Med Sci Monit26, e923621-e923621. PubMed  Europe PubMed DOI
  16. Khilji,M.S., Bresson,S.E., Verstappen,D., Pihl,C., Andersen,P.A.K., Agergaard,J.B., Dahlby,T., Bryde,T.H., Klindt,K., Nielsen,C.K., Walentinsson,A., Zivkovic,D., Bousquet,M.P., Tyrberg,B., Richardson,S.J., Morgan,N.G., Mandrup-Poulsen,T. and Marzec,M.T.
    The inducible beta5i proteasome subunit contributes to proinsulin degradation in GRP94 deficient beta cells and is overexpressed in type 2 diabetes pancreatic islets
    Am J Physiol Endocrinol Metab318, E892-E892. PubMed  Europe PubMed DOI
  17. Li,C., Dai,S., Yan,Z., Zhang,X., Liu,S., Wang,X., Wang,J., Shi,L. and Yao,Y.
    Genetic polymorphisms of proteasome subunit genes of the MHC-I antigen-presenting system are associated with cervical cancer in a Chinese Han population
    Hum Immunol PubMed  Europe PubMed DOI  M
  18. Maurits,E., Degeling,C.G., Kisselev,A.F., Florea,B.I. and Overkleeft,H.S.
    Structure-Based Design of Fluorogenic Substrates Selective for Human Proteasome Subunits
    Chembiochem PubMed  Europe PubMed DOI
  19. Shirazi,F., Jones,R.J., Singh,R.K., Zou,J., Kuiatse,I., Berkova,Z., Wang,H., Lee,H.C., Hong,S., Dick,L., Chattopadhyay,N. and Orlowski,R.Z.
    Activating KRAS, NRAS, and BRAF mutants enhance proteasome capacity and reduce endoplasmic reticulum stress in multiple myeloma
    Proc Natl Acad Sci U S A117, 20004-20014. PubMed  Europe PubMed DOI
  20. Wang,S., Li,J., Wang,T., Bai,J., Zhang,Y.L., Lin,Q.Y., Li,J.M., Zhao,Q., Guo,S.B. and Li,H.H.
    Ablation of immunoproteasome beta5i subunit suppresses hypertensive retinopathy by blocking ATRAP degradation in mice
    Mol Ther28, 279-292. PubMed  Europe PubMed DOI  K
  21. Xie,X., Wang,H.X., Li,N., Deng,Y.W., Bi,H.L., Zhang,Y.L., Xia,Y.L. and Li,H.H.
    Selective Inhibition of the Immunoproteasome beta5i Prevents PTEN Degradation and Attenuates Cardiac Hypertrophy
    Front Pharmacol11, 885-885. PubMed  Europe PubMed DOI  I
    22. 2019
  22. Ettari,R., Cerchia,C., Maiorana,S., Guccione,M., Novellino,E., Bitto,A., Grasso,S., Lavecchia,A. and Zappala,M.
    Development of novel amides as noncovalent inhibitors of immunoproteasomes
    ChemMedChem14, 842-852. PubMed  Europe PubMed DOI  I
  23. Gorny,X., Saring,P., Bergado Acosta,J.R., Kahl,E., Kolodziejczyk,M.H., Cammann,C., Wernecke,K.E.A., Mayer,D., Landgraf,P., Seifert,U., Dieterich,D.C. and Fendt,M.
    Deficiency of the immunoproteasome subunit beta5i/LMP7 supports the anxiogenic effects of mild stress and facilitates cued fear memory in mice
    Brain Behav Immun80, 35-43. PubMed  Europe PubMed DOI  K
  24. Li,F.D., Nie,H., Tian,C., Wang,H.X., Sun,B.H., Ren,H.L., Zhang,X., Liao,P.Z., Liu,D., Li,H.H. and Zheng,Y.H.
    Ablation and inhibition of the immunoproteasome catalytic subunit LMP7 attenuate experimental abdominal aortic aneurysm formation in mice
    J Immunol202, 1176-1185. PubMed  Europe PubMed DOI
  25. Li,J., Wang,S., Zhang,Y.L., Bai,J., Lin,Q.Y., Liu,R.S., Yu,X.H. and Li,H.H.
    Immunoproteasome subunit beta5i promotes Ang II (angiotensin II)-induced atrial fibrillation by targeting ATRAP (Ang II type I receptor-associated protein) degradation in mice
    Hypertension73, 92-101. PubMed  Europe PubMed DOI  K
  26. Min,L., Zeng,X., Li,B., Tao,B., Shi,J., Zhang,W., Sun,Q., Jing,C. and Wang,X.
    Overexpression of immunoproteasome low-molecular-mass polypeptide 7 and inhibiting role of next-generation proteasome inhibitor ONX 0912 on cell growth in glioma
    Neuroreport30, 1031-1038. PubMed  Europe PubMed DOI  I
  27. Xie,X., Bi,H.L., Lai,S., Zhang,Y.L., Li,N., Cao,H.J., Han,L., Wang,H.X. and Li,H.H.
    The immunoproteasome catalytic beta5i subunit regulates cardiac hypertrophy by targeting the autophagy protein ATG5 for degradation
    Sci Adv5, eaau0495-eaau0495. PubMed  Europe PubMed DOI
  28. Yu,J., Liu,J., Li,D., Xu,L., Hong,D., Chang,S., Xu,L., Li,J., Liu,T. and Zhou,Y.
    Exploration of novel macrocyclic dipeptide N-benzyl amides as proteasome inhibitors
    Eur J Med Chem164, 423-439. PubMed  Europe PubMed DOI  I
    29. 2018
  29. Basler,M., Maurits,E., de Bruin,G., Koerner,J., Overkleeft,H.S. and Groettrup,M.
    Amelioration of autoimmunity with an inhibitor selectively targeting all active centres of the immunoproteasome
    Br J Pharmacol175, 38-52. PubMed  Europe PubMed DOI  I
  30. Basler,M., Mundt,S. and Groettrup,M.
    The immunoproteasome subunit LMP7 is required in the murine thymus for filling up a hole in the T cell repertoire
    Eur J Immunol48, 419-429. PubMed  Europe PubMed DOI
  31. Basler,M., Lindstrom,M.M., LaStant,J.J., Bradshaw,J.M., Owens,T.D., Schmidt,C., Maurits,E., Tsu,C., Overkleeft,H.S., Kirk,C.J., Langrish,C.L. and Groettrup,M.
    Co-inhibition of immunoproteasome subunits LMP2 and LMP7 is required to block autoimmunity
    EMBO Rep19, e46512-e46512. PubMed  Europe PubMed DOI  I
  32. Contreras-Cubas,C., Cardenas-Conejo,A., Rodriguez-Velasco,A., Garcia-Ortiz,H., Orozco,L. and Baca,V.
    A homozygous mutation in the PSMB8 gene in a case with proteasome-associated autoinflammatory syndrome
    Scand J Rheumatol47, 251-254. PubMed  Europe PubMed DOI  M
  33. Dani,P., Patnaik,N., Singh,A., Jaiswal,A., Agrawal,B., Kumar,A.A., Varkhande,S.R., Sharma,A., Vaish,U., Ghosh,P., Sharma,V.K., Sharma,P., Verma,G., Kar,H.K., Gupta,S., Natarajan,V.T., Gokhale,R.S. and Rani,R.
    Association and expression of the antigen-processing gene PSMB8, coding for low-molecular-mass protease 7, with vitiligo in North India: case-control study
    Br J Dermatol178, 482-491. PubMed  Europe PubMed DOI  M
    34. 2017
  34. Cui,H., Baur,R., Le Chapelain,C., Dubiella,C., Heinemeyer,W., Huber,E.M. and Groll,M.
    Structural elucidation of a nonpeptidic inhibitor specific for the human immunoproteasome
    Chembiochem18, 523-526. PubMed  Europe PubMed DOI  I
  35. Hewings,D.S., Flygare,J.A., Wertz,I.E. and Bogyo,M.
    Activity-based probes for the multicatalytic proteasome
    FEBS J284, 1540-1554. PubMed  Europe PubMed DOI  V  L  I
  36. Hovhannisyan,A.A., Pham,T.H., Bouvier,D., Tan,X., Touhar,S., Mkryan,G.G., Dallakyan,A.M., El Amri,C., Melikyan,G.S., Reboud-Ravaux,M. and Bouvier-Durand,M.
    Phenoxypropanolamine derivatives as selective inhibitors of the 20S proteasome beta1 and beta5 subunits
    Bioorg Med Chem Lett27, 5172-5178. PubMed  Europe PubMed DOI  I
  37. Koerner,J., Brunner,T. and Groettrup,M.
    Inhibition and deficiency of the immunoproteasome subunit LMP7 suppress the development and progression of colorectal carcinoma in mice
    Oncotarget8, 50873-50888. PubMed  Europe PubMed DOI  I
  38. Liu,H., Wan,C., Ding,Y., Han,R., He,Y., Xiao,J. and Hao,J.
    PR-957, a selective inhibitor of immunoproteasome subunit low-MW polypeptide 7, attenuates experimental autoimmune neuritis by suppressing Th17-cell differentiation and regulating cytokine production
    FASEB J31, 1756-1766. PubMed  Europe PubMed DOI  I
  39. Santos,R.L.A., Bai,L., Singh,P.K., Murakami,N., Fan,H., Zhan,W., Zhu,Y., Jiang,X., Zhang,K., Assker,J.P., Nathan,C.F., Li,H., Azzi,J. and Lin,G.
    Structure of human immunoproteasome with a reversible and noncompetitive inhibitor that selectively inhibits activated lymphocytes
    Nat Commun8, 1692-1692. PubMed  Europe PubMed DOI  S  I
  40. Vachharajani,N., Joeris,T., Luu,M., Hartmann,S., Pautz,S., Jenike,E., Pantazis,G., Prinz,I., Hofer,M.J., Steinhoff,U. and Visekruna,A.
    Prevention of colitis-associated cancer by selective targeting of immunoproteasome subunit LMP7
    Oncotarget8, 50447-50459. PubMed  Europe PubMed DOI  K  I
    41. 2016
  41. de Bruin,G., Xin,B.T., Kraus,M., van der Stelt,M., van der Marel,G.A., Kisselev,A.F., Driessen,C., Florea,B.I. and Overkleeft,H.S.
    A set of activity-based probes to visualize human (immuno)proteasome activities
    Angew Chem Int Ed Engl55, 4199-4203. PubMed  Europe PubMed DOI  A  I
  42. Farini,A., Sitzia,C., Cassani,B., Cassinelli,L., Rigoni,R., Colleoni,F., Fusco,N., Gatti,S., Bella,P., Villa,C., Napolitano,F., Maiavacca,R., Bosari,S., Villa,A. and Torrente,Y.
    Therapeutic potential of immunoproteasome inhibition in Duchenne muscular dystrophy
    Mol Ther24, 1898-1912. PubMed  Europe PubMed DOI  K
  43. Gvozdeva,O.V., Prassolov,V.S., Zenkova,M.A., Vlassov,V.V. and Chernolovskaya,E.L.
    Silencing of inducible immunoproteasome subunit expression by chemically modified siRNA and shRNA
    Nucleosides Nucleotides Nucleic Acids35, 389-403. PubMed  Europe PubMed DOI  K
  44. Huber,E.M., Heinemeyer,W., de Bruin,G., Overkleeft,H.S. and Groll,M.
    A humanized yeast proteasome identifies unique binding modes of inhibitors for the immunosubunit beta5i
    EMBO J35, 2602-2613. PubMed  Europe PubMed DOI  S  I
  45. Kirschner,F., Reppe,K., Andresen,N., Witzenrath,M., Ebstein,F. and Kloetzel,P.M.
    Proteasome beta5i subunit deficiency affects opsonin synthesis and aggravates pneumococcal pneumonia
    PLoS ONE11, e0153847-e0153847. PubMed  Europe PubMed DOI  K
  46. Mundt,S., Engelhardt,B., Kirk,C.J., Groettrup,M. and Basler,M.
    Inhibition and deficiency of the immunoproteasome subunit LMP7 attenuates LCMV-induced meningitis
    Eur J Immunol46, 104-113. PubMed  Europe PubMed DOI
  47. Paeschke,A., Possehl,A., Klingel,K., Voss,M., Voss,K., Kespohl,M., Sauter,M., Overkleeft,H.S., Althof,N., Garlanda,C. and Voigt,A.
    The immunoproteasome controls the availability of the cardioprotective pattern recognition molecule pentraxin3
    Eur J Immunol46, 619-633. PubMed  Europe PubMed DOI
  48. Singh,P.K., Fan,H., Jiang,X., Shi,L., Nathan,C.F. and Lin,G.
    Immunoproteasome beta5i-selective dipeptidomimetic inhibitors
    ChemMedChem11, 2127-2131. PubMed  Europe PubMed DOI  I
  49. Sosic,I., Gobec,M., Brus,B., Knez,D., Zivec,M., Konc,J., Lesnik,S., Ogrizek,M., Obreza,A., Zigon,D., Janezic,D., Mlinaric-Rascan,I. and Gobec,S.
    Nonpeptidic selective inhibitors of the chymotrypsin-like (beta5 i) subunit of the immunoproteasome
    Angew Chem Int Ed Engl55, 5745-5748. PubMed  Europe PubMed DOI  I
  50. Sula Karreci,E., Fan,H., Uehara,M., Mihali,A.B., Singh,P.K., Kurdi,A.T., Solhjou,Z., Riella,L.V., Ghobrial,I., Laragione,T., Routray,S., Assaker,J.P., Wang,R., Sukenick,G., Shi,L., Barrat,F.J., Nathan,C.F., Lin,G. and Azzi,J.
    Brief treatment with a highly selective immunoproteasome inhibitor promotes long-term cardiac allograft acceptance in mice
    Proc Natl Acad Sci U S A113, E8425-E8425. PubMed  Europe PubMed DOI  I
    51. 2015
  51. Basler,M., Mundt,S., Bitzer,A., Schmidt,C. and Groettrup,M.
    The immunoproteasome: a novel drug target for autoimmune diseases
    Clin Exp Rheumatol33, S74-S79. PubMed  Europe PubMed
  52. Brehm,A., Liu,Y., Sheikh,A., Marrero,B., Omoyinmi,E., Zhou,Q., Montealegre,G., Biancotto,A., Reinhardt,A., Almeida de Jesus,A., Pelletier,M., Tsai,W.L., Remmers,E.F., Kardava,L., Hill,S., Kim,H., Lachmann,H.J., Megarbane,A., Chae,J.J., Brady,J., Castillo,R.D., Brown,D., Casano,A.V., Gao,L., Chapelle,D., Huang,Y., Stone,D., Chen,Y., Sotzny,F., Lee,C.C., Kastner,D.L., Torrelo,A., Zlotogorski,A., Moir,S., Gadina,M., McCoy,P., Wesley,R., Rother,K., Hildebrand,P.W., Brogan,P., Kruger,E., Aksentijevich,I. and Goldbach-Mansky,R.
    Additive loss-of-function proteasome subunit mutations in CANDLE/PRAAS patients promote type I IFN production
    J Clin Invest125, 4196-4211. PubMed  Europe PubMed DOI  M
  53. Dubiella,C., Baur,R., Cui,H., Huber,E.M. and Groll,M.
    Selective inhibition of the immunoproteasome by structure-based targeting of a non-catalytic cysteine
    Angew Chem Int Ed Engl54, 15888-15891. PubMed  Europe PubMed DOI  I
  54. Groll,M., Korotkov,V.S., Huber,E.M., de Meijere,A. and Ludwig,A.
    A minimal beta-lactone fragment for selective beta5c or beta5I proteasome inhibitors
    Angew Chem Int Ed Engl54, 7810-7814. PubMed  Europe PubMed DOI  I
  55. Mishto,M., Raza,M.L., de Biase,D., Ravizza,T., Vasuri,F., Martucci,M., Keller,C., Bellavista,E., Buchholz,T.J., Kloetzel,P.M., Pession,A., Vezzani,A. and Heinemann,U.
    The immunoproteasome beta5i subunit is a key contributor to ictogenesis in a rat model of chronic epilepsy
    Brain Behav Immun49, 188-196. PubMed  Europe PubMed DOI  I
  56. Zilberberg,J., Matos,J., Dziopa,E., Dziopa,L., Yang,Z., Kirk,C.J., Assefnia,S. and Korngold,R.
    Inhibition of the immunoproteasome subunit LMP7 with ONX 0914 ameliorates graft-versus-host disease in an MHC-matched minor histocompatibility antigen-disparate murine model
    Biol Blood Marrow Transplant21, 1555-1564. PubMed  Europe PubMed DOI  I
    57. 2014
  57. de Bruin,G., Huber,E.M., Xin,B.T., van Rooden,E.J., Al-Ayed,K., Kim,K.B., Kisselev,A.F., Driessen,C., van der Stelt,M., van der Marel,G.A., Groll,M. and Overkleeft,H.S.
    Structure-based design of beta1i or beta5i specific inhibitors of human immunoproteasomes
    J Med Chem57, 6197-6209. PubMed  Europe PubMed DOI  S  I
  58. Fan,H., Angelo,N.G., Warren,J.D., Nathan,C.F. and Lin,G.
    Oxathiazolones selectively inhibit the human immunoproteasome over the constitutive proteasome
    ACS Med Chem Lett5, 405-410. PubMed  Europe PubMed DOI  I
  59. Noro,M. and Nonaka,M.
    Evolution of dimorphisms of the proteasome subunit beta type 8 gene (PSMB8) in basal ray-finned fish
    Immunogenetics66, 325-334. PubMed  Europe PubMed DOI
    60. 2013
  60. D'Souza,A.J., Desai,S.D., Rudner,X.L., Kelly,M.N., Ruan,S. and Shellito,J.E.
    Suppression of the macrophage proteasome by ethanol impairs MHC class I antigen processing and presentation
    PLoS ONE8, e56890-e56890. PubMed  Europe PubMed DOI  I
  61. Dechavanne,V., Vilbois,F., Glez,L. and Antonsson,B.
    Purification and separation of the 20S immunoproteasome from the constitutive proteasome and identification of the subunits by LC-MS
    Protein Expr Purif87, 100-110. PubMed  Europe PubMed DOI
  62. Huang,C.H., Tanaka,Y., Fujito,N.T. and Nonaka,M.
    Dimorphisms of the proteasome subunit beta type 8 gene (PSMB8) of ectothermic tetrapods originated in multiple independent evolutionary events
    Immunogenetics65, 811-821. PubMed  Europe PubMed DOI
  63. Kunimoto,K., Kimura,A., Uede,K., Okuda,M., Aoyagi,N., Furukawa,F. and Kanazawa,N.
    A new infant case of Nakajo-Nishimura syndrome with a genetic mutation in the immunoproteasome subunit: an overlapping entity with JMP and CANDLE syndrome related to PSMB8 mutations
    Dermatology227, 26-30. PubMed  Europe PubMed DOI  M
  64. Miller,Z., Ao,L., Kim,K.B. and Lee,W.
    Inhibitors of the immunoproteasome: current status and future directions
    Curr Pharm Des19, 4140-4151. PubMed  Europe PubMed  I
  65. Tacchi,L., Misra,M. and Salinas,I.
    Anti-viral immune responses in a primitive lung: Characterization and expression analysis of interferon-inducible immunoproteasome subunits LMP2, LMP7 and MECL-1 in a sarcopterygian fish, the Nigerian spotted lungfish (Protopterus dolloi)
    Dev Comp Immunol41, 657-665. PubMed  Europe PubMed DOI
    66. 2012
  66. Basler,M. and Groettrup,M.
    Immunoproteasome-specific inhibitors and their application
    Methods Mol Biol832, 391-401. PubMed  Europe PubMed DOI  I
  67. Fujito,N.T. and Nonaka,M.
    Highly divergent dimorphic alleles of the proteasome subunit beta type-8 (PSMB8) gene of the bichir Polypterus senegalus: implication for evolution of the PSMB8 gene of jawed vertebrates
    Immunogenetics64, 447-453. PubMed  Europe PubMed DOI
  68. Grawert,M.A. and Groll,M.
    Eukaryotic 20S proteasome
    [ISSN:978-0-12-407742-3]3, 3684-3691. DOI
  69. Ichikawa,H.T., Conley,T., Muchamuel,T., Jiang,J., Lee,S., Owen,T., Barnard,J., Nevarez,S., Goldman,B.I., Kirk,C.J., Looney,R.J. and Anolik,J.H.
    Beneficial effect of novel proteasome inhibitors in murine lupus via dual inhibition of type I interferon and autoantibody-secreting cells
    Arthritis Rheum64, 493-503. PubMed  Europe PubMed DOI  I
  70. Joeris,T., Schmidt,N., Ermert,D., Krienke,P., Visekruna,A., Kuckelkorn,U., Kaufmann,S.H. and Steinhoff,U.
    The proteasome system in infection: impact of beta5 and LMP7 on composition, maturation and quantity of active proteasome complexes
    PLoS ONE7, e39827-e39827. PubMed  Europe PubMed DOI
  71. Lei,B., Adel,H. and Zhan,C.G.
    Structural features and binding free energies for non-covalent inhibitors interacting with immunoproteasome by molecular modeling and dynamics simulations
    Theor Chem Acc131, 1-11. DOI  I
  72. Tsukamoto,K., Miura,F., Fujito,N.T., Yoshizaki,G. and Nonaka,M.
    Long-lived dichotomous lineages of the proteasome subunit beta type 8 (PSMB8) gene surviving more than 500 million years as alleles or paralogs
    Mol Biol Evol29, 3071-3079. PubMed  Europe PubMed DOI
    73. 2011
  73. Arima,K., Kinoshita,A., Mishima,H., Kanazawa,N., Kaneko,T., Mizushima,T., Ichinose,K., Nakamura,H., Tsujino,A., Kawakami,A., Matsunaka,M., Kasagi,S., Kawano,S., Kumagai,S., Ohmura,K., Mimori,T., Hirano,M., Ueno,S., Tanaka,K., Tanaka,M., Toyoshima,I., Sugino,H., Yamakawa,A., Tanaka,K., Niikawa,N., Furukawa,F., Murata,S., Eguchi,K., Ida,H. and Yoshiura,K.
    Proteasome assembly defect due to a proteasome subunit beta type 8 (PSMB8) mutation causes the autoinflammatory disorder, Nakajo-Nishimura syndrome
    Proc Natl Acad Sci U S A108, 14914-14919. PubMed  Europe PubMed DOI  M
  74. Lee,W. and Kim,K.B.
    The immunoproteasome: an emerging therapeutic target
    Curr Top Med Chem11, 2923-2930. PubMed  Europe PubMed
  75. Sijts,E.J. and Kloetzel,P.M.
    The role of the proteasome in the generation of MHC class I ligands and immune responses
    Cell Mol Life Sci68, 1491-1502. PubMed  Europe PubMed DOI  V
  76. Singh,A.V., Bandi,M., Aujay,M.A., Kirk,C.J., Hark,D.E., Raje,N., Chauhan,D. and Anderson,K.C.
    PR-924, a selective inhibitor of the immunoproteasome subunit LMP-7, blocks multiple myeloma cell growth both in vitro and in vivo
    Br J Haematol152, 155-163. PubMed  Europe PubMed DOI  I
  77. Zaiss,D.M., Bekker,C.P., Grone,A., Lie,B.A. and Sijts,A.J.
    Proteasome immunosubunits protect against the development of CD8 T cell-mediated autoimmune diseases
    J Immunol187, 2302-2309. PubMed  Europe PubMed DOI
    78. 2010
  78. Guillaume,B., Chapiro,J., Stroobant,V., Colau,D., Van Holle,B., Parvizi,G., Bousquet-Dubouch,M.P., Theate,I., Parmentier,N. and Van den Eynde,B.J.
    Two abundant proteasome subtypes that uniquely process some antigens presented by HLA class I molecules
    Proc Natl Acad Sci U S A107, 18599-18604. PubMed  Europe PubMed DOI
  79. Roccaro,A.M., Sacco,A., Aujay,M., Ngo,H.T., Azab,A.K., Azab,F., Quang,P., Maiso,P., Runnels,J., Anderson,K.C., Demo,S. and Ghobrial,I.M.
    Selective inhibition of chymotrypsin-like activity of the immunoproteasome and constitutive proteasome in Waldenstrom macroglobulinemia
    Blood115, 4051-4060. PubMed  Europe PubMed DOI  I
    80. 2009
  80. Muchamuel,T., Basler,M., Aujay,M.A., Suzuki,E., Kalim,K.W., Lauer,C., Sylvain,C., Ring,E.R., Shields,J., Jiang,J., Shwonek,P., Parlati,F., Demo,S.D., Bennett,M.K., Kirk,C.J. and Groettrup,M.
    A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis
    Nat Med15, 781-787. PubMed  Europe PubMed DOI  I
  81. Parlati,F., Lee,S.J., Aujay,M., Suzuki,E., Levitsky,K., Lorens,J.B., Micklem,D.R., Ruurs,P., Sylvain,C., Lu,Y., Shenk,K.D. and Bennett,M.K.
    Carfilzomib can induce tumor cell death through selective inhibition of the chymotrypsin-like activity of the proteasome
    Blood114, 3439-3447. PubMed  Europe PubMed DOI  I
  82. Zhou,H.J., Aujay,M.A., Bennett,M.K., Dajee,M., Demo,S.D., Fang,Y., Ho,M.N., Jiang,J., Kirk,C.J., Laidig,G.J., Lewis,E.R., Lu,Y., Muchamuel,T., Parlati,F., Ring,E., Shenk,K.D., Shields,J., Shwonek,P.J., Stanton,T., Sun,C.M., Sylvain,C., Woo,T.M. and Yang,J.
    Design and synthesis of an orally bioavailable and selective peptide epoxyketone proteasome inhibitor (PR-047)
    J Med Chem52, 3028-3038. PubMed  Europe PubMed DOI  I
    83. 2006
  83. [YEAR:1-6-2006]Areste,C. and Blackbourn,D.J.
    HIV Tat-mediated transcriptional regulation of proteasome protein cleavage specificity
    Biochem J396, e13-e15. PubMed  Europe PubMed DOI
  84. [YEAR:15-1-2006]Heink,S., Fricke,B., Ludwig,D., Kloetzel,P.M. and Kruger,E.
    Tumor cell lines expressing the proteasome subunit isoform LMP7E1 exhibit immunoproteasome deficiency
    Cancer Res66, 649-652. PubMed  Europe PubMed DOI  M
    85. 2005
  85. Bos,D.H.
    Natural selection during functional divergence to LMP7 and proteasome subunit X (PSMB5) following gene duplication
    J Mol Evol60, 221-228. PubMed  Europe PubMed DOI
    86. 2004
  86. [YEAR:15-9-2004]Basler,M., Youhnovski,N., Van Den Broek,M., Przybylski,M. and Groettrup,M.
    Immunoproteasomes down-regulate presentation of a subdominant T cell epitope from lymphocytic choriomeningitis virus
    J Immunol173, 3925-3934. PubMed  Europe PubMed
  87. [YEAR:10-8-2004]Khu,Y.L., Tan,Y.J., Lim,S.G., Hong,W. and Goh,P.Y.
    Hepatitis C virus non-structural protein NS3 interacts with LMP7, a component of the immunoproteasome, and affects its proteasome activity
    Biochem J384, 401-409. PubMed  Europe PubMed DOI
  88. Seemuller,E., Dolenc,I. and Lupas,A.
    Eukaryotic 20S proteasome
    [ISSN:0-12-079610-4]2, 2068-2077.  V
    89. 2003
  89. Kesmir,C., van Noort,V., de Boer,R.J. and Hogeweg,P.
    Bioinformatic analysis of functional differences between the immunoproteasome and the constitutive proteasome
    Immunogenetics55, 437-449. PubMed  Europe PubMed DOI
  90. Kruger,E., Kuckelkorn,U., Sijts,A. and Kloetzel,P.M.
    The components of the proteasome system and their role in MHC class I antigen processing
    Rev Physiol Biochem Pharmacol148, 81-104. PubMed  Europe PubMed DOI
    91. 2002
  91. [YEAR:18-2-2002]Schultz,E.S., Chapiro,J., Lurquin,C., Claverol,S., Burlet-Schiltz,O., Warnier,G., Russo,V., Morel,S., Levy,F., Boon,T., Van den Eynde,B.J. and van der Bruggen,P.
    The production of a new MAGE-3 peptide presented to cytolytic T lymphocytes by HLA-B40 requires the immunoproteasome
    J Exp Med195, 391-399. PubMed  Europe PubMed DOI
  92. [YEAR:15-9-2002]Singh,S., Awasthi,N., Egwuagu,C.E. and Wagner,B.J.
    Immunoproteasome expression in a nonimmune tissue, the ocular lens
    Arch Biochem Biophys405, 147-153. PubMed  Europe PubMed DOI
  93. Unno,M., Mizushima,T., Morimoto,Y., Tomisugi,Y., Tanaka,K., Yasuoka,N. and Tsukihara,T.
    The structure of the mammalian 20S proteasome at 2.75 A resolution
    Structure10, 609-618. PubMed  Europe PubMed DOI  S
    94. 2001
  94. [YEAR:2-7-2001]Toes,R.E., Nussbaum,A.K., Degermann,S., Schirle,M., Emmerich,N.P., Kraft,M., Laplace,C., Zwinderman,A., Dick,T.P., Muller,J., Schonfisch,B., Schmid,C., Fehling,H.J., Stevanovic,S., Rammensee,H.G. and Schild,H.
    Discrete cleavage motifs of constitutive and immunoproteasomes revealed by quantitative analysis of cleavage products
    J Exp Med194, 1-12. PubMed  Europe PubMed DOI
    95. 2000
  95. [YEAR:15-10-2000]Clark,M.S., Pontarotti,P., Gilles,A., Kelly,A. and Elgar,G.
    Identification and characterization of a beta proteasome subunit cluster in the Japanese pufferfish (Fugu rubripes)
    J Immunol165, 4446-4452. PubMed  Europe PubMed
  96. [YEAR:4-8-2000]Kingsbury,D.J., Griffin,T.A. and Colbert,R.A.
    Novel propeptide function in 20 S proteasome assembly influences beta subunit composition
    J Biol Chem275, 24156-24162. PubMed  Europe PubMed DOI
  97. [YEAR:19-5-2000]Kisselev,A.F., Songyang,Z. and Goldberg,A.L.
    Why does threonine, and not serine, function as the active site nucleophile in proteasomes?
    J Biol Chem275, 14831-14837. PubMed  Europe PubMed DOI  I
  98. Nelson,J.E., Loukissa,A., Altschuller-Felberg,C., Monaco,J.J., Fallon,J.T. and Cardozo,C.
    Up-regulation of the proteasome subunit LMP7 in tissues of endotoxemic rats
    J Lab Clin Med135, 324-331. PubMed  Europe PubMed DOI
  99. [YEAR:15-7-2000]Schwarz,K., Van Den Broek,M., Kostka,S., Kraft,R., Soza,A., Schmidtke,G., Kloetzel,P.M. and Groettrup,M.
    Overexpression of the proteasome subunits LMP2, LMP7, and MECL-1, but not PA28alpha/beta, enhances the presentation of an immunodominant lymphocytic choriomeningitis virus T cell epitope
    J Immunol165, 768-778. PubMed  Europe PubMed
  100. [YEAR:4-8-2000]Witt,E., Zantopf,D., Schmidt,M., Kraft,R., Kloetzel,P.M. and Kruger,E.
    Characterisation of the newly identified human Ump1 homologue POMP and analysis of LMP7(beta5i) incorporation into 20 S proteasomes
    J Mol Biol301, 1-9. PubMed  Europe PubMed DOI
    101. 1998
  101. [YEAR:5-1-1998]Griffin,T.A., Nandi,D., Cruz,M., Fehling,H.J., Van Kaer,L., Monaco,J.J. and Colbert,R.A.
    Immunoproteasome assembly: cooperative incorporation of interferon gamma (IFN-gamma)-inducible subunits
    J Exp Med187, 97-104. PubMed  Europe PubMed DOI
    102. 1997
  102. Eleuteri,A.M., Kohanski,R.A., Cardozo,C. and Orlowski,M.
    Bovine spleen multicatalytic proteinase complex (proteasome). Replacement of X, Y, and Z subunits by LMP7, LMP2, and MECL1 and changes in properties and specificity
    J Biol Chem272, 11824-11831. PubMed  Europe PubMed DOI
  103. Hughes,A.L.
    Evolution of the proteasome components
    Immunogenetics46, 82-92. PubMed  Europe PubMed DOI
  104. Nonaka,M., Namikawa-Yamada,C., Sasaki,M., Salter-Cid,L. and Flajnik,M.F.
    Evolution of proteasome subunits delta and LMP2: complementary DNA cloning and linkage analysis with MHC in lower vertebrates
    J Immunol159, 734-740. PubMed  Europe PubMed
    105. 1996
  105. Coux,O., Tanaka,K. and Goldberg,A.L.
    Structure and functions of the 20S and 26S proteasomes
    Annu Rev Biochem65, 801-847. PubMed  Europe PubMed DOI
  106. Pancer,Z., Scheffer,U., Muller,I. and Muller,W.E.
    Cloning of sponge (Geodia cydonium) and tunicate (Botryllus schlosseri) proteasome subunit epsilon (PRCE): Implications about the vertebrate MHC-encoded homologue LMP7 (PRCC)
    Biochem Biophys Res Commun228, 406-410. PubMed  Europe PubMed DOI
    107. 1995
  107. [YEAR:6-10-1995]Groettrup,M., Ruppert,T., Kuehn,L., Seeger,M., Standera,S., Koszinowski,U. and Kloetzel,P.M.
    The interferon-gamma-inducible 11 S regulator (PA28) and the LMP2/LMP7 subunits govern the peptide production by the 20 S proteasome in vitro
    J Biol Chem270, 23808-23815. PubMed  Europe PubMed DOI

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