Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Literature for peptidase T01.015: proteasome subunit beta5i

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, M Mutation, K Knockout, I Inhibitor, L Localization, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2026
  1. Grigorieva,E.V., Burov,A.V., Starodubova,E.S., Lebedev,T.D., Rezvykh,A.P., Belogurov,A.A., Jr., Spirin,P.V., Prassolov,V.S., Karpov,V.L. and Morozov,A.V.<br>Transmission of Non-Constitutive Proteasomes Between Cells via Extracellular Vesicles<br>Int J Mol Sci (2026) 27 PubMed  Europe PubMed DOI  PMC  EPMC
    2. 2025
  2. Woo,M.S., Brand,J., Bal,L.C., Moritz,M., Walkenhorst,M., Vieira,V., Ipenberg,I., Rothammer,N., Wang,M., Dogan,B., Loreth,D., Mayer,C., Nagel,D., Wagner,I., Pfeffer,L.K., Landgraf,P., van Ham,M., Mattern,K.M., Winschel,I., Frantz,N., Sonner,J.K., Grosshans,H.K., Miguela,A., Bauer,S., Meurs,N., Muller,A., Binkle-Ladisch,L., Salinas,G., Jansch,L., Dieterich,D.C., Riedner,M., Kruger,E., Heppner,F.L., Glatzel,M., Puelles,V.G., Engler,J.B., Nyengaard,J.R., Misgeld,T., Kerschensteiner,M., Merkler,D., Meyer-Schwesinger,C. and Friese,M.A.<br>The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis<br>Cell (2025) 188, 6097-6103. PubMed  Europe PubMed DOI
    3. 2024
  3. Albornoz,N., Alvarez-Indo,J., de la Pena,A., Arias-Munoz,E., Coca,A., Segovia-Miranda,F., Kerr,B., Budini,M., Criollo,A., Garcia-Robles,M.A., Morselli,E., Soza,A. and Burgos,P.V.<br>Targeting the immunoproteasome in hypothalamic neurons as a novel therapeutic strategy for high-fat diet-induced obesity and metabolic dysregulation<br>J Neuroinflammation (2024) 21, 191-191. PubMed  Europe PubMed DOI  PMC  EPMC
  4. Arai,Y., Shitama,H., Yamagishi,M., Ono,S., Kashima,A., Hiraizumi,M., Tsuda,N., Katayama,K., Tanaka,K., Koda,Y., Kato,S., Sakata,K., Nureki,O. and Miyazaki,H.<br>Optimization of alpha-amido boronic acids via cryo-electron microscopy analysis: Discovery of a novel highly selective immunoproteasome subunit LMP7 (beta5i)/LMP2 (beta1i) dual inhibitor<br>Bioorg Med Chem (2024) 109, 117790-117790. PubMed  Europe PubMed DOI  I
    5. 2023
  5. Elhawary,N.A., Ekram,S.N., Abumansour,I.S., Azher,Z.A., AlJahdali,I.A., Alyamani,N.M., Naffadi,H.M., Sindi,I.A., Baazeem,A., Nassir,A.M. and Mufti,A.H.<br>Sequence Variants in PSMB8/PSMB9 Immunoproteasome Genes and Risk of Urothelial Bladder Carcinoma<br>Cureus (2023) 15, e36293-e36293. PubMed  Europe PubMed DOI  PMC  EPMC
  6. Li,J., Liu,N., Zhou,H., Xian,P., Song,Y., Tang,X., Li,Y. and Basler,M.<br>Immunoproteasome inhibition prevents progression of castration-resistant prostate cancer<br>Br J Cancer (2023) 128, 1377-1390. PubMed  Europe PubMed DOI  PMC  EPMC
  7. Li,J., Hu,S., Johnson,H.W.B., Kirk,C.J., Xian,P., Song,Y., Li,Y., Liu,N., Groettrup,M. and Basler,M.<br>Co-inhibition of immunoproteasome subunits LMP2 and LMP7 enables prevention of transplant arteriosclerosis<br>Cardiovasc Res (2023) 119, 1030-1045. PubMed  Europe PubMed DOI
  8. Li,Y., Nan,G., Hou,X., Yan,Y., Yang,Y., Yang,Y., Li,K. and Xiao,Z.<br>Non-peptidic immunoproteasome beta5i-selective inhibitor as potential treatment for idiopathic pulmonary fibrosis: Virtual screening, hit evolution and lead identification<br>Eur J Med Chem (2023) 261, 115856-115856. PubMed  Europe PubMed DOI  I
  9. Wang,M., Liu,Y., Dai,L., Zhong,X., Zhang,W., Xie,Y., Zeng,H. and Wang,H.<br>ONX0914 inhibition of immunoproteasome subunit LMP7 ameliorates diabetic cardiomyopathy via restraining endothelial-mesenchymal transition<br>Clin Sci (Lond) (2023) 137, 1297-1309. PubMed  Europe PubMed DOI
    10. 2022
  10. Guo,T., Liu,C., Yang,C., Wu,J., Su,P. and Chen,J.<br>Immunoproteasome subunit PSMB8 regulates microglia-mediated neuroinflammation upon manganese exposure by PERK signaling<br>Food Chem Toxicol (2022) 163, 112951-112951. PubMed  Europe PubMed DOI
    11. 2021
  11. Ah Kioon,M.D., Pierides,M., Pannellini,T., Lin,G., Nathan,C.F. and Barrat,F.J.<br>Noncytotoxic Inhibition of the Immunoproteasome Regulates Human Immune Cells In Vitro and Suppresses Cutaneous Inflammation in the Mouse<br>J Immunol (2021) 206, 1631-1641. PubMed  Europe PubMed DOI  PMC  EPMC  I
  12. El-Esawy,F.M., Abd El-Kareem,H.M., Mohamady,A.A., Agamy,A.M.M. and Salem,R.M.<br>Proteasome Subunit Beta Type-8 (PSMB8) Gene Polymorphisms in Vitiligo: A Possible Predictor of Auditory Involvement<br>J Clin Aesthet Dermatol (2021) 14, 30-35. PubMed  Europe PubMed  PMC  EPMC
  13. Kollar,L., Gobec,M., Szilagyi,B., Proj,M., Knez,D., Abranyi-Balogh,P., Petri,L., Imre,T., Bajusz,D., Ferenczy,G.G., Gobec,S., Keseru,G.M. and Sosic,I.<br>Discovery of selective fragment-sized immunoproteasome inhibitors<br>Eur J Med Chem (2021) 219, 113455-113455. PubMed  Europe PubMed DOI
  14. Schiffrer,E.S., Proj,M., Gobec,M., Rejc,L., Sterman,A., Mravljak,J., Gobec,S. and Sosic,I.<br>Synthesis and Biochemical Evaluation of Warhead-Decorated Psoralens as (Immuno)Proteasome Inhibitors<br>Molecules (2021) 26 PubMed  Europe PubMed DOI  PMC  EPMC
  15. Sloot,W., Glaser,N., Hansen,A., Hellmann,J., Jaeckel,S., Johannes,S., Knippel,A., Lai,V. and Onidi,M.<br>Improved nonclinical safety profile of a novel, highly selective inhibitor of the immunoproteasome subunit LMP7 (M3258)<br>Toxicol Appl Pharmacol (2021) 429, 115695-115695. PubMed  Europe PubMed DOI  I
    16. 2020
  16. Caputi,F.F., Di Cesare Mannelli,L., Rullo,L., Micheli,L., Stamatakos,S., Posa,L., Ghelardini,C., Romualdi,P. and Candeletti,S.<br>The active second-generation proteasome inhibitor oprozomib reverts the oxaliplatin-induced neuropathy symptoms<br>Biochem Pharmacol (2020) 182, 114255-114255. PubMed  Europe PubMed DOI  I
  17. Chen,N.X., Liu,K., Liu,X., Zhang,X.X. and Han,D.Y.<br>Induction and Regulation of the Immunoproteasome Subunit beta5i (PSMB8) in Laryngeal and Hypopharyngeal Carcinoma Cells<br>Med Sci Monit (2020) 26, e923621-e923621. PubMed  Europe PubMed DOI  PMC  EPMC
  18. Khilji,M.S., Bresson,S.E., Verstappen,D., Pihl,C., Andersen,P.A.K., Agergaard,J.B., Dahlby,T., Bryde,T.H., Klindt,K., Nielsen,C.K., Walentinsson,A., Zivkovic,D., Bousquet,M.P., Tyrberg,B., Richardson,S.J., Morgan,N.G., Mandrup-Poulsen,T. and Marzec,M.T.<br>The inducible beta5i proteasome subunit contributes to proinsulin degradation in GRP94 deficient beta cells and is overexpressed in type 2 diabetes pancreatic islets<br>Am J Physiol Endocrinol Metab (2020) 318, E892-E892. PubMed  Europe PubMed DOI
  19. Li,C., Dai,S., Yan,Z., Zhang,X., Liu,S., Wang,X., Wang,J., Shi,L. and Yao,Y.<br>Genetic polymorphisms of proteasome subunit genes of the MHC-I antigen-presenting system are associated with cervical cancer in a Chinese Han population<br>Hum Immunol (2020) PubMed  Europe PubMed DOI  M
  20. Maurits,E., Degeling,C.G., Kisselev,A.F., Florea,B.I. and Overkleeft,H.S.<br>Structure-Based Design of Fluorogenic Substrates Selective for Human Proteasome Subunits<br>Chembiochem (2020) PubMed  Europe PubMed DOI
  21. Shirazi,F., Jones,R.J., Singh,R.K., Zou,J., Kuiatse,I., Berkova,Z., Wang,H., Lee,H.C., Hong,S., Dick,L., Chattopadhyay,N. and Orlowski,R.Z.<br>Activating KRAS, NRAS, and BRAF mutants enhance proteasome capacity and reduce endoplasmic reticulum stress in multiple myeloma<br>Proc Natl Acad Sci U S A (2020) 117, 20004-20014. PubMed  Europe PubMed DOI
  22. Wang,S., Li,J., Wang,T., Bai,J., Zhang,Y.L., Lin,Q.Y., Li,J.M., Zhao,Q., Guo,S.B. and Li,H.H.<br>Ablation of immunoproteasome beta5i subunit suppresses hypertensive retinopathy by blocking ATRAP degradation in mice<br>Mol Ther (2020) 28, 279-292. PubMed  Europe PubMed DOI  K
  23. Xie,X., Wang,H.X., Li,N., Deng,Y.W., Bi,H.L., Zhang,Y.L., Xia,Y.L. and Li,H.H.<br>Selective Inhibition of the Immunoproteasome beta5i Prevents PTEN Degradation and Attenuates Cardiac Hypertrophy<br>Front Pharmacol (2020) 11, 885-885. PubMed  Europe PubMed DOI  PMC  EPMC  I
    24. 2019
  24. Ettari,R., Cerchia,C., Maiorana,S., Guccione,M., Novellino,E., Bitto,A., Grasso,S., Lavecchia,A. and Zappala,M.<br>Development of novel amides as noncovalent inhibitors of immunoproteasomes<br>ChemMedChem (2019) 14, 842-852. PubMed  Europe PubMed DOI  I
  25. Gorny,X., Saring,P., Bergado Acosta,J.R., Kahl,E., Kolodziejczyk,M.H., Cammann,C., Wernecke,K.E.A., Mayer,D., Landgraf,P., Seifert,U., Dieterich,D.C. and Fendt,M.<br>Deficiency of the immunoproteasome subunit beta5i/LMP7 supports the anxiogenic effects of mild stress and facilitates cued fear memory in mice<br>Brain Behav Immun (2019) 80, 35-43. PubMed  Europe PubMed DOI  K
  26. Li,F.D., Nie,H., Tian,C., Wang,H.X., Sun,B.H., Ren,H.L., Zhang,X., Liao,P.Z., Liu,D., Li,H.H. and Zheng,Y.H.<br>Ablation and inhibition of the immunoproteasome catalytic subunit LMP7 attenuate experimental abdominal aortic aneurysm formation in mice<br>J Immunol (2019) 202, 1176-1185. PubMed  Europe PubMed DOI
  27. Li,J., Wang,S., Zhang,Y.L., Bai,J., Lin,Q.Y., Liu,R.S., Yu,X.H. and Li,H.H.<br>Immunoproteasome subunit beta5i promotes Ang II (angiotensin II)-induced atrial fibrillation by targeting ATRAP (Ang II type I receptor-associated protein) degradation in mice<br>Hypertension (2019) 73, 92-101. PubMed  Europe PubMed DOI  K
  28. Min,L., Zeng,X., Li,B., Tao,B., Shi,J., Zhang,W., Sun,Q., Jing,C. and Wang,X.<br>Overexpression of immunoproteasome low-molecular-mass polypeptide 7 and inhibiting role of next-generation proteasome inhibitor ONX 0912 on cell growth in glioma<br>Neuroreport (2019) 30, 1031-1038. PubMed  Europe PubMed DOI  I
  29. Xie,X., Bi,H.L., Lai,S., Zhang,Y.L., Li,N., Cao,H.J., Han,L., Wang,H.X. and Li,H.H.<br>The immunoproteasome catalytic beta5i subunit regulates cardiac hypertrophy by targeting the autophagy protein ATG5 for degradation<br>Sci Adv (2019) 5, eaau0495-eaau0495. PubMed  Europe PubMed DOI  PMC  EPMC
  30. Yu,J., Liu,J., Li,D., Xu,L., Hong,D., Chang,S., Xu,L., Li,J., Liu,T. and Zhou,Y.<br>Exploration of novel macrocyclic dipeptide N-benzyl amides as proteasome inhibitors<br>Eur J Med Chem (2019) 164, 423-439. PubMed  Europe PubMed DOI  I
    31. 2018
  31. Basler,M., Maurits,E., de Bruin,G., Koerner,J., Overkleeft,H.S. and Groettrup,M.<br>Amelioration of autoimmunity with an inhibitor selectively targeting all active centres of the immunoproteasome<br>Br J Pharmacol (2018) 175, 38-52. PubMed  Europe PubMed DOI  I
  32. Basler,M., Mundt,S. and Groettrup,M.<br>The immunoproteasome subunit LMP7 is required in the murine thymus for filling up a hole in the T cell repertoire<br>Eur J Immunol (2018) 48, 419-429. PubMed  Europe PubMed DOI
  33. Basler,M., Lindstrom,M.M., LaStant,J.J., Bradshaw,J.M., Owens,T.D., Schmidt,C., Maurits,E., Tsu,C., Overkleeft,H.S., Kirk,C.J., Langrish,C.L. and Groettrup,M.<br>Co-inhibition of immunoproteasome subunits LMP2 and LMP7 is required to block autoimmunity<br>EMBO Rep (2018) 19, e46512-e46512. PubMed  Europe PubMed DOI  I
  34. Contreras-Cubas,C., Cardenas-Conejo,A., Rodriguez-Velasco,A., Garcia-Ortiz,H., Orozco,L. and Baca,V.<br>A homozygous mutation in the PSMB8 gene in a case with proteasome-associated autoinflammatory syndrome<br>Scand J Rheumatol (2018) 47, 251-254. PubMed  Europe PubMed DOI  M
  35. Dani,P., Patnaik,N., Singh,A., Jaiswal,A., Agrawal,B., Kumar,A.A., Varkhande,S.R., Sharma,A., Vaish,U., Ghosh,P., Sharma,V.K., Sharma,P., Verma,G., Kar,H.K., Gupta,S., Natarajan,V.T., Gokhale,R.S. and Rani,R.<br>Association and expression of the antigen-processing gene PSMB8, coding for low-molecular-mass protease 7, with vitiligo in North India: case-control study<br>Br J Dermatol (2018) 178, 482-491. PubMed  Europe PubMed DOI  M
    36. 2017
  36. Cui,H., Baur,R., Le Chapelain,C., Dubiella,C., Heinemeyer,W., Huber,E.M. and Groll,M.<br>Structural elucidation of a nonpeptidic inhibitor specific for the human immunoproteasome<br>Chembiochem (2017) 18, 523-526. PubMed  Europe PubMed DOI  I
  37. Hewings,D.S., Flygare,J.A., Wertz,I.E. and Bogyo,M.<br>Activity-based probes for the multicatalytic proteasome<br>FEBS J (2017) 284, 1540-1554. PubMed  Europe PubMed DOI  V  L  I
  38. Hovhannisyan,A.A., Pham,T.H., Bouvier,D., Tan,X., Touhar,S., Mkryan,G.G., Dallakyan,A.M., El Amri,C., Melikyan,G.S., Reboud-Ravaux,M. and Bouvier-Durand,M.<br>Phenoxypropanolamine derivatives as selective inhibitors of the 20S proteasome beta1 and beta5 subunits<br>Bioorg Med Chem Lett (2017) 27, 5172-5178. PubMed  Europe PubMed DOI  I
  39. Koerner,J., Brunner,T. and Groettrup,M.<br>Inhibition and deficiency of the immunoproteasome subunit LMP7 suppress the development and progression of colorectal carcinoma in mice<br>Oncotarget (2017) 8, 50873-50888. PubMed  Europe PubMed DOI  I
  40. Liu,H., Wan,C., Ding,Y., Han,R., He,Y., Xiao,J. and Hao,J.<br>PR-957, a selective inhibitor of immunoproteasome subunit low-MW polypeptide 7, attenuates experimental autoimmune neuritis by suppressing Th17-cell differentiation and regulating cytokine production<br>FASEB J (2017) 31, 1756-1766. PubMed  Europe PubMed DOI  I
  41. Santos,R.L.A., Bai,L., Singh,P.K., Murakami,N., Fan,H., Zhan,W., Zhu,Y., Jiang,X., Zhang,K., Assker,J.P., Nathan,C.F., Li,H., Azzi,J. and Lin,G.<br>Structure of human immunoproteasome with a reversible and noncompetitive inhibitor that selectively inhibits activated lymphocytes<br>Nat Commun (2017) 8, 1692-1692. PubMed  Europe PubMed DOI  PMC  EPMC  S  I
  42. Vachharajani,N., Joeris,T., Luu,M., Hartmann,S., Pautz,S., Jenike,E., Pantazis,G., Prinz,I., Hofer,M.J., Steinhoff,U. and Visekruna,A.<br>Prevention of colitis-associated cancer by selective targeting of immunoproteasome subunit LMP7<br>Oncotarget (2017) 8, 50447-50459. PubMed  Europe PubMed DOI  K  I
    43. 2016
  43. de Bruin,G., Xin,B.T., Kraus,M., van der Stelt,M., van der Marel,G.A., Kisselev,A.F., Driessen,C., Florea,B.I. and Overkleeft,H.S.<br>A set of activity-based probes to visualize human (immuno)proteasome activities<br>Angew Chem Int Ed Engl (2016) 55, 4199-4203. PubMed  Europe PubMed DOI  A  I
  44. Farini,A., Sitzia,C., Cassani,B., Cassinelli,L., Rigoni,R., Colleoni,F., Fusco,N., Gatti,S., Bella,P., Villa,C., Napolitano,F., Maiavacca,R., Bosari,S., Villa,A. and Torrente,Y.<br>Therapeutic potential of immunoproteasome inhibition in Duchenne muscular dystrophy<br>Mol Ther (2016) 24, 1898-1912. PubMed  Europe PubMed DOI  K
  45. Gvozdeva,O.V., Prassolov,V.S., Zenkova,M.A., Vlassov,V.V. and Chernolovskaya,E.L.<br>Silencing of inducible immunoproteasome subunit expression by chemically modified siRNA and shRNA<br>Nucleosides Nucleotides Nucleic Acids (2016) 35, 389-403. PubMed  Europe PubMed DOI  K
  46. Huber,E.M., Heinemeyer,W., de Bruin,G., Overkleeft,H.S. and Groll,M.<br>A humanized yeast proteasome identifies unique binding modes of inhibitors for the immunosubunit beta5i<br>EMBO J (2016) 35, 2602-2613. PubMed  Europe PubMed DOI  S  I
  47. Kirschner,F., Reppe,K., Andresen,N., Witzenrath,M., Ebstein,F. and Kloetzel,P.M.<br>Proteasome beta5i subunit deficiency affects opsonin synthesis and aggravates pneumococcal pneumonia<br>PLoS ONE (2016) 11, e0153847-e0153847. PubMed  Europe PubMed DOI  PMC  EPMC  K
  48. Mundt,S., Engelhardt,B., Kirk,C.J., Groettrup,M. and Basler,M.<br>Inhibition and deficiency of the immunoproteasome subunit LMP7 attenuates LCMV-induced meningitis<br>Eur J Immunol (2016) 46, 104-113. PubMed  Europe PubMed DOI
  49. Paeschke,A., Possehl,A., Klingel,K., Voss,M., Voss,K., Kespohl,M., Sauter,M., Overkleeft,H.S., Althof,N., Garlanda,C. and Voigt,A.<br>The immunoproteasome controls the availability of the cardioprotective pattern recognition molecule pentraxin3<br>Eur J Immunol (2016) 46, 619-633. PubMed  Europe PubMed DOI
  50. Singh,P.K., Fan,H., Jiang,X., Shi,L., Nathan,C.F. and Lin,G.<br>Immunoproteasome beta5i-selective dipeptidomimetic inhibitors<br>ChemMedChem (2016) 11, 2127-2131. PubMed  Europe PubMed DOI  I
  51. Sosic,I., Gobec,M., Brus,B., Knez,D., Zivec,M., Konc,J., Lesnik,S., Ogrizek,M., Obreza,A., Zigon,D., Janezic,D., Mlinaric-Rascan,I. and Gobec,S.<br>Nonpeptidic selective inhibitors of the chymotrypsin-like (beta5 i) subunit of the immunoproteasome<br>Angew Chem Int Ed Engl (2016) 55, 5745-5748. PubMed  Europe PubMed DOI  I
  52. Sula Karreci,E., Fan,H., Uehara,M., Mihali,A.B., Singh,P.K., Kurdi,A.T., Solhjou,Z., Riella,L.V., Ghobrial,I., Laragione,T., Routray,S., Assaker,J.P., Wang,R., Sukenick,G., Shi,L., Barrat,F.J., Nathan,C.F., Lin,G. and Azzi,J.<br>Brief treatment with a highly selective immunoproteasome inhibitor promotes long-term cardiac allograft acceptance in mice<br>Proc Natl Acad Sci U S A (2016) 113, E8425-E8425. PubMed  Europe PubMed DOI  I
    53. 2015
  53. Basler,M., Mundt,S., Bitzer,A., Schmidt,C. and Groettrup,M.<br>The immunoproteasome: a novel drug target for autoimmune diseases<br>Clin Exp Rheumatol (2015) 33, S74-S79. PubMed  Europe PubMed
  54. Brehm,A., Liu,Y., Sheikh,A., Marrero,B., Omoyinmi,E., Zhou,Q., Montealegre,G., Biancotto,A., Reinhardt,A., Almeida de Jesus,A., Pelletier,M., Tsai,W.L., Remmers,E.F., Kardava,L., Hill,S., Kim,H., Lachmann,H.J., Megarbane,A., Chae,J.J., Brady,J., Castillo,R.D., Brown,D., Casano,A.V., Gao,L., Chapelle,D., Huang,Y., Stone,D., Chen,Y., Sotzny,F., Lee,C.C., Kastner,D.L., Torrelo,A., Zlotogorski,A., Moir,S., Gadina,M., McCoy,P., Wesley,R., Rother,K., Hildebrand,P.W., Brogan,P., Kruger,E., Aksentijevich,I. and Goldbach-Mansky,R.<br>Additive loss-of-function proteasome subunit mutations in CANDLE/PRAAS patients promote type I IFN production<br>J Clin Invest (2015) 125, 4196-4211. PubMed  Europe PubMed DOI  M
  55. Dubiella,C., Baur,R., Cui,H., Huber,E.M. and Groll,M.<br>Selective inhibition of the immunoproteasome by structure-based targeting of a non-catalytic cysteine<br>Angew Chem Int Ed Engl (2015) 54, 15888-15891. PubMed  Europe PubMed DOI  I
  56. Groll,M., Korotkov,V.S., Huber,E.M., de Meijere,A. and Ludwig,A.<br>A minimal beta-lactone fragment for selective beta5c or beta5I proteasome inhibitors<br>Angew Chem Int Ed Engl (2015) 54, 7810-7814. PubMed  Europe PubMed DOI  I
  57. Mishto,M., Raza,M.L., de Biase,D., Ravizza,T., Vasuri,F., Martucci,M., Keller,C., Bellavista,E., Buchholz,T.J., Kloetzel,P.M., Pession,A., Vezzani,A. and Heinemann,U.<br>The immunoproteasome beta5i subunit is a key contributor to ictogenesis in a rat model of chronic epilepsy<br>Brain Behav Immun (2015) 49, 188-196. PubMed  Europe PubMed DOI  I
  58. Zilberberg,J., Matos,J., Dziopa,E., Dziopa,L., Yang,Z., Kirk,C.J., Assefnia,S. and Korngold,R.<br>Inhibition of the immunoproteasome subunit LMP7 with ONX 0914 ameliorates graft-versus-host disease in an MHC-matched minor histocompatibility antigen-disparate murine model<br>Biol Blood Marrow Transplant (2015) 21, 1555-1564. PubMed  Europe PubMed DOI  I
    59. 2014
  59. de Bruin,G., Huber,E.M., Xin,B.T., van Rooden,E.J., Al-Ayed,K., Kim,K.B., Kisselev,A.F., Driessen,C., van der Stelt,M., van der Marel,G.A., Groll,M. and Overkleeft,H.S.<br>Structure-based design of beta1i or beta5i specific inhibitors of human immunoproteasomes<br>J Med Chem (2014) 57, 6197-6209. PubMed  Europe PubMed DOI  S  I
  60. Fan,H., Angelo,N.G., Warren,J.D., Nathan,C.F. and Lin,G.<br>Oxathiazolones selectively inhibit the human immunoproteasome over the constitutive proteasome<br>ACS Med Chem Lett (2014) 5, 405-410. PubMed  Europe PubMed DOI  I
  61. Noro,M. and Nonaka,M.<br>Evolution of dimorphisms of the proteasome subunit beta type 8 gene (PSMB8) in basal ray-finned fish<br>Immunogenetics (2014) 66, 325-334. PubMed  Europe PubMed DOI
    62. 2013
  62. D'Souza,A.J., Desai,S.D., Rudner,X.L., Kelly,M.N., Ruan,S. and Shellito,J.E.<br>Suppression of the macrophage proteasome by ethanol impairs MHC class I antigen processing and presentation<br>PLoS ONE (2013) 8, e56890-e56890. PubMed  Europe PubMed DOI  PMC  EPMC  I
  63. Dechavanne,V., Vilbois,F., Glez,L. and Antonsson,B.<br>Purification and separation of the 20S immunoproteasome from the constitutive proteasome and identification of the subunits by LC-MS<br>Protein Expr Purif (2013) 87, 100-110. PubMed  Europe PubMed DOI
  64. Huang,C.H., Tanaka,Y., Fujito,N.T. and Nonaka,M.<br>Dimorphisms of the proteasome subunit beta type 8 gene (PSMB8) of ectothermic tetrapods originated in multiple independent evolutionary events<br>Immunogenetics (2013) 65, 811-821. PubMed  Europe PubMed DOI
  65. Kunimoto,K., Kimura,A., Uede,K., Okuda,M., Aoyagi,N., Furukawa,F. and Kanazawa,N.<br>A new infant case of Nakajo-Nishimura syndrome with a genetic mutation in the immunoproteasome subunit: an overlapping entity with JMP and CANDLE syndrome related to PSMB8 mutations<br>Dermatology (2013) 227, 26-30. PubMed  Europe PubMed DOI  M
  66. Miller,Z., Ao,L., Kim,K.B. and Lee,W.<br>Inhibitors of the immunoproteasome: current status and future directions<br>Curr Pharm Des (2013) 19, 4140-4151. PubMed  Europe PubMed  I
  67. Tacchi,L., Misra,M. and Salinas,I.<br>Anti-viral immune responses in a primitive lung: Characterization and expression analysis of interferon-inducible immunoproteasome subunits LMP2, LMP7 and MECL-1 in a sarcopterygian fish, the Nigerian spotted lungfish (Protopterus dolloi)<br>Dev Comp Immunol (2013) 41, 657-665. PubMed  Europe PubMed DOI
    68. 2012
  68. Basler,M. and Groettrup,M.<br>Immunoproteasome-specific inhibitors and their application<br>Methods Mol Biol (2012) 832, 391-401. PubMed  Europe PubMed DOI  I
  69. Fujito,N.T. and Nonaka,M.<br>Highly divergent dimorphic alleles of the proteasome subunit beta type-8 (PSMB8) gene of the bichir Polypterus senegalus: implication for evolution of the PSMB8 gene of jawed vertebrates<br>Immunogenetics (2012) 64, 447-453. PubMed  Europe PubMed DOI
  70. Grawert,M.A. and Groll,M.<br>Eukaryotic 20S proteasome<br>[ISSN:978-0-12-407742-3] (2012) 3, 3684-3691. DOI
  71. Ichikawa,H.T., Conley,T., Muchamuel,T., Jiang,J., Lee,S., Owen,T., Barnard,J., Nevarez,S., Goldman,B.I., Kirk,C.J., Looney,R.J. and Anolik,J.H.<br>Beneficial effect of novel proteasome inhibitors in murine lupus via dual inhibition of type I interferon and autoantibody-secreting cells<br>Arthritis Rheum (2012) 64, 493-503. PubMed  Europe PubMed DOI  I
  72. Joeris,T., Schmidt,N., Ermert,D., Krienke,P., Visekruna,A., Kuckelkorn,U., Kaufmann,S.H. and Steinhoff,U.<br>The proteasome system in infection: impact of beta5 and LMP7 on composition, maturation and quantity of active proteasome complexes<br>PLoS ONE (2012) 7, e39827-e39827. PubMed  Europe PubMed DOI  PMC  EPMC
  73. Lei,B., Adel,H. and Zhan,C.G.<br>Structural features and binding free energies for non-covalent inhibitors interacting with immunoproteasome by molecular modeling and dynamics simulations<br>Theor Chem Acc (2012) 131, 1-11. DOI  I
  74. Tsukamoto,K., Miura,F., Fujito,N.T., Yoshizaki,G. and Nonaka,M.<br>Long-lived dichotomous lineages of the proteasome subunit beta type 8 (PSMB8) gene surviving more than 500 million years as alleles or paralogs<br>Mol Biol Evol (2012) 29, 3071-3079. PubMed  Europe PubMed DOI
    75. 2011
  75. Arima,K., Kinoshita,A., Mishima,H., Kanazawa,N., Kaneko,T., Mizushima,T., Ichinose,K., Nakamura,H., Tsujino,A., Kawakami,A., Matsunaka,M., Kasagi,S., Kawano,S., Kumagai,S., Ohmura,K., Mimori,T., Hirano,M., Ueno,S., Tanaka,K., Tanaka,M., Toyoshima,I., Sugino,H., Yamakawa,A., Tanaka,K., Niikawa,N., Furukawa,F., Murata,S., Eguchi,K., Ida,H. and Yoshiura,K.<br>Proteasome assembly defect due to a proteasome subunit beta type 8 (PSMB8) mutation causes the autoinflammatory disorder, Nakajo-Nishimura syndrome<br>Proc Natl Acad Sci U S A (2011) 108, 14914-14919. PubMed  Europe PubMed DOI  M
  76. Lee,W. and Kim,K.B.<br>The immunoproteasome: an emerging therapeutic target<br>Curr Top Med Chem (2011) 11, 2923-2930. PubMed  Europe PubMed
  77. Sijts,E.J. and Kloetzel,P.M.<br>The role of the proteasome in the generation of MHC class I ligands and immune responses<br>Cell Mol Life Sci (2011) 68, 1491-1502. PubMed  Europe PubMed DOI  V
  78. Singh,A.V., Bandi,M., Aujay,M.A., Kirk,C.J., Hark,D.E., Raje,N., Chauhan,D. and Anderson,K.C.<br>PR-924, a selective inhibitor of the immunoproteasome subunit LMP-7, blocks multiple myeloma cell growth both in vitro and in vivo<br>Br J Haematol (2011) 152, 155-163. PubMed  Europe PubMed DOI  I
  79. Zaiss,D.M., Bekker,C.P., Grone,A., Lie,B.A. and Sijts,A.J.<br>Proteasome immunosubunits protect against the development of CD8 T cell-mediated autoimmune diseases<br>J Immunol (2011) 187, 2302-2309. PubMed  Europe PubMed DOI
    80. 2010
  80. Guillaume,B., Chapiro,J., Stroobant,V., Colau,D., Van Holle,B., Parvizi,G., Bousquet-Dubouch,M.P., Theate,I., Parmentier,N. and Van den Eynde,B.J.<br>Two abundant proteasome subtypes that uniquely process some antigens presented by HLA class I molecules<br>Proc Natl Acad Sci U S A (2010) 107, 18599-18604. PubMed  Europe PubMed DOI
  81. Roccaro,A.M., Sacco,A., Aujay,M., Ngo,H.T., Azab,A.K., Azab,F., Quang,P., Maiso,P., Runnels,J., Anderson,K.C., Demo,S. and Ghobrial,I.M.<br>Selective inhibition of chymotrypsin-like activity of the immunoproteasome and constitutive proteasome in Waldenstrom macroglobulinemia<br>Blood (2010) 115, 4051-4060. PubMed  Europe PubMed DOI  I
    82. 2009
  82. Muchamuel,T., Basler,M., Aujay,M.A., Suzuki,E., Kalim,K.W., Lauer,C., Sylvain,C., Ring,E.R., Shields,J., Jiang,J., Shwonek,P., Parlati,F., Demo,S.D., Bennett,M.K., Kirk,C.J. and Groettrup,M.<br>A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis<br>Nat Med (2009) 15, 781-787. PubMed  Europe PubMed DOI  I
  83. Parlati,F., Lee,S.J., Aujay,M., Suzuki,E., Levitsky,K., Lorens,J.B., Micklem,D.R., Ruurs,P., Sylvain,C., Lu,Y., Shenk,K.D. and Bennett,M.K.<br>Carfilzomib can induce tumor cell death through selective inhibition of the chymotrypsin-like activity of the proteasome<br>Blood (2009) 114, 3439-3447. PubMed  Europe PubMed DOI  I
  84. Zhou,H.J., Aujay,M.A., Bennett,M.K., Dajee,M., Demo,S.D., Fang,Y., Ho,M.N., Jiang,J., Kirk,C.J., Laidig,G.J., Lewis,E.R., Lu,Y., Muchamuel,T., Parlati,F., Ring,E., Shenk,K.D., Shields,J., Shwonek,P.J., Stanton,T., Sun,C.M., Sylvain,C., Woo,T.M. and Yang,J.<br>Design and synthesis of an orally bioavailable and selective peptide epoxyketone proteasome inhibitor (PR-047)<br>J Med Chem (2009) 52, 3028-3038. PubMed  Europe PubMed DOI  I
    85. 2006
  85. [YEAR:1-6-2006]Areste,C. and Blackbourn,D.J.<br>HIV Tat-mediated transcriptional regulation of proteasome protein cleavage specificity<br>Biochem J (1-6-2006) 396, e13-e15. PubMed  Europe PubMed DOI  PMC  EPMC
  86. [YEAR:15-1-2006]Heink,S., Fricke,B., Ludwig,D., Kloetzel,P.M. and Kruger,E.<br>Tumor cell lines expressing the proteasome subunit isoform LMP7E1 exhibit immunoproteasome deficiency<br>Cancer Res (15-1-2006) 66, 649-652. PubMed  Europe PubMed DOI  M
    87. 2005
  87. Bos,D.H.<br>Natural selection during functional divergence to LMP7 and proteasome subunit X (PSMB5) following gene duplication<br>J Mol Evol (2005) 60, 221-228. PubMed  Europe PubMed DOI
    88. 2004
  88. [YEAR:15-9-2004]Basler,M., Youhnovski,N., Van Den Broek,M., Przybylski,M. and Groettrup,M.<br>Immunoproteasomes down-regulate presentation of a subdominant T cell epitope from lymphocytic choriomeningitis virus<br>J Immunol (15-9-2004) 173, 3925-3934. PubMed  Europe PubMed
  89. [YEAR:10-8-2004]Khu,Y.L., Tan,Y.J., Lim,S.G., Hong,W. and Goh,P.Y.<br>Hepatitis C virus non-structural protein NS3 interacts with LMP7, a component of the immunoproteasome, and affects its proteasome activity<br>Biochem J (10-8-2004) 384, 401-409. PubMed  Europe PubMed DOI  PMC  EPMC
  90. Seemuller,E., Dolenc,I. and Lupas,A.<br>Eukaryotic 20S proteasome<br>[ISSN:0-12-079610-4] (2004) 2, 2068-2077.  V
    91. 2003
  91. Kesmir,C., van Noort,V., de Boer,R.J. and Hogeweg,P.<br>Bioinformatic analysis of functional differences between the immunoproteasome and the constitutive proteasome<br>Immunogenetics (2003) 55, 437-449. PubMed  Europe PubMed DOI
  92. Kruger,E., Kuckelkorn,U., Sijts,A. and Kloetzel,P.M.<br>The components of the proteasome system and their role in MHC class I antigen processing<br>Rev Physiol Biochem Pharmacol (2003) 148, 81-104. PubMed  Europe PubMed DOI
    93. 2002
  93. [YEAR:18-2-2002]Schultz,E.S., Chapiro,J., Lurquin,C., Claverol,S., Burlet-Schiltz,O., Warnier,G., Russo,V., Morel,S., Levy,F., Boon,T., Van den Eynde,B.J. and van der Bruggen,P.<br>The production of a new MAGE-3 peptide presented to cytolytic T lymphocytes by HLA-B40 requires the immunoproteasome<br>J Exp Med (18-2-2002) 195, 391-399. PubMed  Europe PubMed DOI  PMC  EPMC
  94. [YEAR:15-9-2002]Singh,S., Awasthi,N., Egwuagu,C.E. and Wagner,B.J.<br>Immunoproteasome expression in a nonimmune tissue, the ocular lens<br>Arch Biochem Biophys (15-9-2002) 405, 147-153. PubMed  Europe PubMed DOI
  95. Unno,M., Mizushima,T., Morimoto,Y., Tomisugi,Y., Tanaka,K., Yasuoka,N. and Tsukihara,T.<br>The structure of the mammalian 20S proteasome at 2.75 A resolution<br>Structure (2002) 10, 609-618. PubMed  Europe PubMed DOI  S
    96. 2001
  96. [YEAR:2-7-2001]Toes,R.E., Nussbaum,A.K., Degermann,S., Schirle,M., Emmerich,N.P., Kraft,M., Laplace,C., Zwinderman,A., Dick,T.P., Muller,J., Schonfisch,B., Schmid,C., Fehling,H.J., Stevanovic,S., Rammensee,H.G. and Schild,H.<br>Discrete cleavage motifs of constitutive and immunoproteasomes revealed by quantitative analysis of cleavage products<br>J Exp Med (2-7-2001) 194, 1-12. PubMed  Europe PubMed DOI  PMC  EPMC
    97. 2000
  97. [YEAR:15-10-2000]Clark,M.S., Pontarotti,P., Gilles,A., Kelly,A. and Elgar,G.<br>Identification and characterization of a beta proteasome subunit cluster in the Japanese pufferfish (Fugu rubripes)<br>J Immunol (15-10-2000) 165, 4446-4452. PubMed  Europe PubMed
  98. [YEAR:4-8-2000]Kingsbury,D.J., Griffin,T.A. and Colbert,R.A.<br>Novel propeptide function in 20 S proteasome assembly influences beta subunit composition<br>J Biol Chem (4-8-2000) 275, 24156-24162. PubMed  Europe PubMed DOI
  99. [YEAR:19-5-2000]Kisselev,A.F., Songyang,Z. and Goldberg,A.L.<br>Why does threonine, and not serine, function as the active site nucleophile in proteasomes?<br>J Biol Chem (19-5-2000) 275, 14831-14837. PubMed  Europe PubMed DOI  I
  100. Nelson,J.E., Loukissa,A., Altschuller-Felberg,C., Monaco,J.J., Fallon,J.T. and Cardozo,C.<br>Up-regulation of the proteasome subunit LMP7 in tissues of endotoxemic rats<br>J Lab Clin Med (2000) 135, 324-331. PubMed  Europe PubMed DOI
  101. [YEAR:15-7-2000]Schwarz,K., Van Den Broek,M., Kostka,S., Kraft,R., Soza,A., Schmidtke,G., Kloetzel,P.M. and Groettrup,M.<br>Overexpression of the proteasome subunits LMP2, LMP7, and MECL-1, but not PA28alpha/beta, enhances the presentation of an immunodominant lymphocytic choriomeningitis virus T cell epitope<br>J Immunol (15-7-2000) 165, 768-778. PubMed  Europe PubMed
  102. [YEAR:4-8-2000]Witt,E., Zantopf,D., Schmidt,M., Kraft,R., Kloetzel,P.M. and Kruger,E.<br>Characterisation of the newly identified human Ump1 homologue POMP and analysis of LMP7(beta5i) incorporation into 20 S proteasomes<br>J Mol Biol (4-8-2000) 301, 1-9. PubMed  Europe PubMed DOI
    103. 1998
  103. [YEAR:5-1-1998]Griffin,T.A., Nandi,D., Cruz,M., Fehling,H.J., Van Kaer,L., Monaco,J.J. and Colbert,R.A.<br>Immunoproteasome assembly: cooperative incorporation of interferon gamma (IFN-gamma)-inducible subunits<br>J Exp Med (5-1-1998) 187, 97-104. PubMed  Europe PubMed DOI  PMC  EPMC
    104. 1997
  104. Eleuteri,A.M., Kohanski,R.A., Cardozo,C. and Orlowski,M.<br>Bovine spleen multicatalytic proteinase complex (proteasome). Replacement of X, Y, and Z subunits by LMP7, LMP2, and MECL1 and changes in properties and specificity<br>J Biol Chem (1997) 272, 11824-11831. PubMed  Europe PubMed DOI
  105. Hughes,A.L.<br>Evolution of the proteasome components<br>Immunogenetics (1997) 46, 82-92. PubMed  Europe PubMed DOI
  106. Nonaka,M., Namikawa-Yamada,C., Sasaki,M., Salter-Cid,L. and Flajnik,M.F.<br>Evolution of proteasome subunits delta and LMP2: complementary DNA cloning and linkage analysis with MHC in lower vertebrates<br>J Immunol (1997) 159, 734-740. PubMed  Europe PubMed
    107. 1996
  107. Coux,O., Tanaka,K. and Goldberg,A.L.<br>Structure and functions of the 20S and 26S proteasomes<br>Annu Rev Biochem (1996) 65, 801-847. PubMed  Europe PubMed DOI
  108. Pancer,Z., Scheffer,U., Muller,I. and Muller,W.E.<br>Cloning of sponge (Geodia cydonium) and tunicate (Botryllus schlosseri) proteasome subunit epsilon (PRCE): Implications about the vertebrate MHC-encoded homologue LMP7 (PRCC)<br>Biochem Biophys Res Commun (1996) 228, 406-410. PubMed  Europe PubMed DOI
    109. 1995
  109. [YEAR:6-10-1995]Groettrup,M., Ruppert,T., Kuehn,L., Seeger,M., Standera,S., Koszinowski,U. and Kloetzel,P.M.<br>The interferon-gamma-inducible 11 S regulator (PA28) and the LMP2/LMP7 subunits govern the peptide production by the 20 S proteasome in vitro<br>J Biol Chem (6-10-1995) 270, 23808-23815. PubMed  Europe PubMed DOI

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2025 EBI
Terms of use