$VAR1 = undef;
Summary for peptidase T01.015: proteasome subunit beta5i
| Names | |
|---|---|
| MEROPS Name | proteasome subunit beta5i |
| Other names | immunoproteasome catalytic subunit 3, LMP7 (Homo sapiens), large multifunctional protease 7, low molecular mass peptide 7, proteasome catalytic subunit 3i, immunoproteasome subunit beta5i, proteasome subunit beta 8, RING10 (Homo sapiens), proteasome subunit Y2 (Homo sapiens), PSMB8 g.p. (Homo sapiens) |
| Domain architecture |
|---|
| MEROPS Classification | |
|---|---|
| Classification | Clan PB >> Subclan PB(T) >> Family T1 >> Subfamily A >> T01.015 |
| Holotype | proteasome subunit beta5i (Homo sapiens), Uniprot accession P28062 (peptidase unit: 73-276), MERNUM MER0000555 |
| History | Identifier created: MEROPS 3.02 (25 June 1998) |
| Activity | |||
|---|---|---|---|
| Catalytic type | Threonine | ||
| NC-IUBMB | Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.25 (Threonine-type endopeptidases) >> Peptidase 3.4.25.1 | ||
| Enzymology | BRENDA database | ||
| Activity status | human: active (Seemuller et al., 2004) mouse: active (Groettrup et al., 1995) | ||
| Physiology | One of the peptidase units of the 20 S proteasome that is preferentially expressed upon stimulation of the immune system, and then partially replaces subunit 3 in the multipeptidase complex. May be particularly effective in the generation of antigenic peptides for the MHC class II system. | ||
| Pharmaceutical relevance | Proteasome inhibitors exhibit anti-inflammatory and antiproliferative effects, and it is threrefore considered that inhibitors have the potential to be drugs for conditions such as cancer, rhuematoid arthritis and psoriasis that are characterised by these processes (Delcros et al., 2003; Elliott et al., 2003). | ||
| Pathways | KEGG | Proteasome | |
| Other databases | TREEFAM | http://www.treefam.org/family/TF106223 | |
| Human genetics | ||||||
|---|---|---|---|---|---|---|
| Gene symbol | Locus | Megabases | Ensembl | Entrez gene | Gene Cards | OMIM |
| PSMB8 | 6p21.3 | ENSG00000168396 | 5696 | PSMB8 | 177046 | |
