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Literature for peptidase S41.011: chlamydial protease-like activity factor

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, A Assay, T Target, I Inhibitor, K Knockout, P Specificity, E Expression, U Therapeutic, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Chen,W., Su,X., Pan,Y., Zhou,H., Gao,Y., Wang,X., Jiang,L., Zeng,L., Xu,Q., Yu,X., Yin,X., Feng,Z., Zhang,B., Zhao,W., Xue,Y., Tang,L. and Zheng,H.
    Chlamydial protease-like activity factor targets SLC7A11 for degradation to induce ferroptosis and facilitate progeny releases
    PLoS Pathog (2025) 21, e1013060-e1013060. PubMed  Europe PubMed DOI
    2. 2024
  2. Poston,T.B., Girardi,J., Kim,M., Zwarycz,P., Polson,A.G., Yount,K., Hanlan,C., Salas,I.J., Lammert,S.M., Arroyo,D., Bruno,T., Wu,M., Rozzelle,J., Fairman,J., Esser-Kahn,A. and Darville,T.
    Intranasal immunization with CPAF combined with cyclic-di-AMP induces a memory CD4 T cell response and reduces bacterial burden following intravaginal infection with Chlamydia muridarum
    bioRxiv (2024) PubMed  Europe PubMed DOI  PMC  EPMC
    3. 2019
  3. Dudiak,B.M., Maksimchuk,K.R., Bednar,M.M., Podracky,C.J., Burg,J.M., Nguyen,T.M., Nwogbo,F.O., Valdivia,R.H. and McCafferty,D.G.
    Insights into the autoproteolytic processing and catalytic mechanism of the Chlamydia trachomatis virulence-associated protease CPAF
    Biochemistry (2019) 58, 3527-3536. PubMed  Europe PubMed DOI  A
    4. 2018
  4. Fenner,A.
    Chlamydia paralyses neutrophils via CPAF
    Nat Rev Urol (2018) 15, 526-527. PubMed  Europe PubMed DOI
  5. Prusty,B.K., Chowdhury,S.R., Gulve,N. and Rudel,T.
    Peptidase inhibitor 15 (PI15) regulates chlamydial CPAF activity
    Front Cell Infect Microbiol (2018) 8, 183-183. PubMed  Europe PubMed DOI  PMC  EPMC
  6. Rajeeve,K., Das,S., Prusty,B.K. and Rudel,T.
    Chlamydia trachomatis paralyses neutrophils to evade the host innate immune response
    Nat Microbiol (2018) 3, 824-835. PubMed  Europe PubMed DOI
    7. 2017
  7. Singh,G., Sharma,D., Singh,V., Rani,J., Marotta,F., Kumar,M., Mal,G. and Singh,B.
    In silico functional elucidation of uncharacterized proteins of Chlamydia abortus strain LLG
    Future Sci OA (2017) 3, FSO169-FSO169. PubMed  Europe PubMed DOI  PMC  EPMC
  8. Wali,S., Gupta,R., Yu,J.J., Lanka,G.K.K., Chambers,J.P., Guentzel,M.N., Zhong,G., Murthy,A.K. and Arulanandam,B.P.
    Chlamydial protease-like activity factor mediated protection against C. trachomatis in guinea pigs
    Immunol Cell Biol (2017) 95, 454-460. PubMed  Europe PubMed DOI
    9. 2016
  9. Biniossek,M.L., Niemer,M., Maksimchuk,K., Mayer,B., Fuchs,J., Huesgen,P.F., McCafferty,D.G., Turk,B., Fritz,G., Mayer,J., Haecker,G., Mach,L. and Schilling,O.
    Identification of protease specificity by combining proteome-derived peptide libraries and quantitative proteomics
    Mol Cell Proteomics (2016) 15, 2515-2524. PubMed  Europe PubMed DOI  P
  10. Maksimchuk,K.R., Alser,K.A., Mou,R., Valdivia,R.H. and McCafferty,D.G.
    The Chlamydia trachomatis protease CPAF contains a cryptic PDZ-like domain with similarity to human cell polarity and tight junction PDZ-containing proteins
    PLoS ONE (2016) 11, e0147233-e0147233. PubMed  Europe PubMed DOI  PMC  EPMC  S
  11. Patton,M.J., McCorrister,S., Grant,C., Westmacott,G., Fariss,R., Hu,P., Zhao,K., Blake,M., Whitmire,B., Yang,C., Caldwell,H.D. and McClarty,G.
    Chlamydial protease-like activity factor and type III secreted effectors cooperate in inhibition of p65 nuclear translocation
    MBio (2016) 7 PubMed  Europe PubMed DOI
  12. Yang,Z., Tang,L., Shao,L., Zhang,Y., Zhang,T., Schenken,R., Valdivia,R. and Zhong,G.
    The chlamydia-secreted protease CPAF promotes chlamydial survival in the mouse lower genital tract
    Infect Immun (2016) 84, 2697-2702. PubMed  Europe PubMed DOI  K
  13. Yang,Z., Tang,L., Zhou,Z. and Zhong,G.
    Neutralizing antichlamydial activity of complement by Chlamydia-secreted protease CPAF
    Microbes Infect (2016) 18, 669-674. PubMed  Europe PubMed DOI
    14. 2015
  14. Johnson,K.A., Lee,J.K., Chen,A.L., Tan,M. and Sutterlin,C.
    Induction and inhibition of CPAF activity during analysis of Chlamydia-infected cells
    Pathog Dis (2015) 73, 1-8. PubMed  Europe PubMed DOI
  15. Tang,L., Chen,J., Zhou,Z., Yu,P., Yang,Z. and Zhong,G.
    Chlamydia-secreted protease CPAF degrades host antimicrobial peptides
    Microbes Infect (2015) 17, 402-408. PubMed  Europe PubMed DOI
    16. 2014
  16. Bavoil,P.M. and Byrne,G.I.
    Analysis of CPAF mutants: new functions, new questions (The ins and outs of a chlamydial protease)
    Pathog Dis (2014) 71, 287-291. PubMed  Europe PubMed DOI
  17. Brown,H.M., Knowlton,A.E., Snavely,E., Nguyen,B.D., Richards,T.S. and Grieshaber,S.S.
    Multinucleation during C. trachomatis infections is caused by the contribution of two effector pathways
    PLoS ONE (2014) 9, e100763-e100763. PubMed  Europe PubMed DOI  PMC  EPMC
  18. Davydov,D.I. and Zigangirova,N.A.
    [Chlamydia trachomatis proteasome protein as one of the significant pathogenicity factors of exciter]
    Mol Gen Mikrobiol Virusol (2014) , 3-8. PubMed  Europe PubMed  V
  19. Davydova,D.Yu. and Zigangirova,N.A.
    Chlamydia trachomatis proteasome protein as a significant pathogenicity factor
    Mol Genet Microbiol Virol (2014) 29, 47-52. DOI
  20. Dille,S., Herbst,K., Volceanov,L., Nolke,T., Kretz,O. and Hacker,G.
    Golgi fragmentation and sphingomyelin transport to Chlamydia trachomatis during penicillin-induced persistence do not depend on the cytosolic presence of the chlamydial protease CPAF
    PLoS ONE (2014) 9, e103220-e103220. PubMed  Europe PubMed DOI  PMC  EPMC
  21. Grieshaber,S.S. and Grieshaber,N.A.
    The role of the chlamydial effector CPAF in the induction of genomic instability
    Pathog Dis (2014) 72, 5-6. PubMed  Europe PubMed DOI
  22. Hacker,G.
    The chlamydial protease CPAF: important or not, important for what?
    Microbes Infect (2014) 16, 367-370. PubMed  Europe PubMed DOI  V
  23. Snavely,E.A., Kokes,M., Dunn,J.D., Saka,H.A., Nguyen,B.D., Bastidas,R.J., McCafferty,D.G. and Valdivia,R.H.
    Reassessing the role of the secreted protease CPAF in Chlamydia trachomatis infection through genetic approaches
    Pathog Dis (2014) 71, 336-351. PubMed  Europe PubMed DOI
  24. Tan,M. and Sutterlin,C.
    The chlamydia protease CPAF: caution, precautions and function
    Pathog Dis (2014) 72, 7-9. PubMed  Europe PubMed DOI
  25. Zhong,G.
    Question the questions on CPAF
    Pathog Dis (2014) 72, 3-4. PubMed  Europe PubMed DOI
    26. 2013
  26. Conrad,T.A., Yang,Z., Ojcius,D. and Zhong,G.
    A path forward for the chlamydial virulence factor CPAF
    Microbes Infect (2013) 15, 1026-1032. PubMed  Europe PubMed DOI  V
  27. Hou,S., Lei,L., Yang,Z., Qi,M., Liu,Q. and Zhong,G.
    Chlamydia trachomatis outer membrane complex protein B (OmcB) is processed by the protease CPAF
    J Bacteriol (2013) 195, 951-957. PubMed  Europe PubMed DOI  I
  28. Matsuo,J., Nakamura,S., Ito,A., Yamazaki,T., Ishida,K., Hayashi,Y., Yoshida,M., Takahashi,K., Sekizuka,T., Takeuchi,F., Kuroda,M., Nagai,H., Hayashida,K., Sugimoto,C. and Yamaguchi,H.
    Protochlamydia induces apoptosis of human HEp-2 cells through mitochondrial dysfunction mediated by chlamydial protease-like activity factor
    PLoS ONE (2013) 8, e56005-e56005. PubMed  Europe PubMed DOI  PMC  EPMC  I
    29. 2012
  29. Chai,J. and Zhong,G.
    Chlamydial protease/proteasome-like activity factor
    [ISSN:978-0-12-407742-3] (2012) 3, 3616-3623. DOI
  30. Chen,A.L., Johnson,K.A., Lee,J.K., Sutterlin,C. and Tan,M.
    CPAF: a chlamydial protease in search of an authentic substrate
    PLoS Pathog (2012) 8, e1002842-e1002842. PubMed  Europe PubMed DOI  PMC  EPMC
    31. 2011
  31. Bednar,M.M., Jorgensen,I., Valdivia,R.H. and McCafferty,D.G.
    Chlamydia protease-like activity factor (CPAF): characterization of proteolysis activity in vitro and development of a nanomolar affinity CPAF zymogen-derived inhibitor
    Biochemistry (2011) 50, 7441-7443. PubMed  Europe PubMed DOI  I
  32. Christian,J.G., Heymann,J., Paschen,S.A., Vier,J., Schauenburg,L., Rupp,J., Meyer,T.F., Hacker,G. and Heuer,D.
    Targeting of a chlamydial protease impedes intracellular bacterial growth
    PLoS Pathog (2011) 7, e1002283-e1002283. PubMed  Europe PubMed DOI  PMC  EPMC  I
  33. Jorgensen,I., Bednar,M.M., Amin,V., Davis,B.K., Ting,J.P., McCafferty,D.G. and Valdivia,R.H.
    The chlamydia protease CPAF regulates host and bacterial proteins to maintain pathogen vacuole integrity and promote virulence
    Cell Host Microbe (2011) 10, 21-32. PubMed  Europe PubMed DOI
  34. Li,W., Murthy,A.K., Chaganty,B.K., Guentzel,M.N., Seshu,J., Chambers,J.P., Zhong,G. and Arulanandam,B.P.
    Immunization with dendritic cells pulsed ex vivo with recombinant chlamydial protease-like activity factor induces protective immunity against genital Chlamydia muridarum challenge
    Front Immunol (2011) 2, 73-73. PubMed  Europe PubMed DOI
  35. Murthy,A.K., Li,W., Guentzel,M.N., Zhong,G. and Arulanandam,B.P.
    Vaccination with the defined chlamydial secreted protein CPAF induces robust protection against female infertility following repeated genital chlamydial challenge
    Vaccine (2011) 29, 2519-2522. PubMed  Europe PubMed DOI
  36. Zhong,G.
    Chlamydia trachomatis secretion of proteases for manipulating host signaling pathways
    Front Microbiol (2011) 2, 14-14. PubMed  Europe PubMed DOI  PMC  EPMC
    37. 2010
  37. Chaganty,B.K., Murthy,A.K., Evani,S.J., Li,W., Guentzel,M.N., Chambers,J.P., Zhong,G. and Arulanandam,B.P.
    Heat denatured enzymatically inactive recombinant chlamydial protease-like activity factor induces robust protective immunity against genital chlamydial challenge
    Vaccine (2010) 28, 2323-2329. PubMed  Europe PubMed DOI  U
  38. Chen,D., Lei,L., Flores,R., Huang,Z., Wu,Z., Chai,J. and Zhong,G.
    Autoprocessing and self-activation of the secreted protease CPAF in Chlamydia-infected cells
    Microb Pathog (2010) 49, 164-173. PubMed  Europe PubMed DOI
  39. Chen,D., Lei,L., Lu,C., Flores,R., DeLisa,M.P., Roberts,T.C., Romesberg,F.E. and Zhong,G.
    Secretion of the chlamydial virulence factor CPAF requires the Sec-dependent pathway
    Microbiology (Reading) (2010) 156, 3031-3040. PubMed  Europe PubMed DOI
  40. Christian,J., Vier,J., Paschen,S.A. and Hacker,G.
    Cleavage of the NF-kappaB family protein p65/RelA by the chlamydial protease-like activity factor (CPAF) impairs proinflammatory signaling in cells Infected with Chlamydiae
    J Biol Chem (2010) 285, 41320-41327. PubMed  Europe PubMed DOI
  41. Hu,Z., Wu,Y.M., Cheng,H.L., Zheng,J.H., Zhou,Z. and Tang,G.F.
    Chlamydial protease-like activity factor from Chlamydophila pneumoniae induced THP-1 cells produced proinflammatory cytokines and apoptosis
    Chin J Microbiol Immunol (2010) 30, 487-492. DOI
  42. Peschel,G., Kernschmidt,L., Cirl,C., Wantia,N., Ertl,T., Durr,S., Wagner,H., Miethke,T. and Rodriguez,N.
    Chlamydophila pneumoniae downregulates MHC-class II expression by two cell type-specific mechanisms
    Mol Microbiol (2010) 76, 648-661. PubMed  Europe PubMed DOI
  43. Yu,H., Schwarzer,K., Forster,M., Kniemeyer,O., Forsbach-Birk,V., Straube,E. and Rodel,J.
    Role of high-mobility group box 1 protein and poly(ADP-ribose) polymerase 1 degradation in Chlamydia trachomatis-induced cytopathicity
    Infect Immun (2010) 78, 3288-3297. PubMed  Europe PubMed DOI
    44. 2009
  44. Chen,D., Chai,J., Hart,P.J. and Zhong,G.
    Identifying catalytic residues in CPAF, a Chlamydia-secreted protease
    Arch Biochem Biophys (2009) 485, 16-23. PubMed  Europe PubMed DOI  PMC  EPMC
  45. Heuer,D., Rejman Lipinski,A., Machuy,N., Karlas,A., Wehrens,A., Siedler,F., Brinkmann,V. and Meyer,T.F.
    Chlamydia causes fragmentation of the Golgi compartment to ensure reproduction
    Nature (2009) 457, 731-735. PubMed  Europe PubMed DOI  I
  46. Murthy,A.K., Guentzel,M.N., Zhong,G. and Arulanandam,B.P.
    Chlamydial protease-like activity factor - insights into immunity and vaccine development
    J Reprod Immunol (2009) 83, 179-184. PubMed  Europe PubMed DOI
  47. Sun,J. and Schoborg,R.V.
    The host adherens junction molecule nectin-1 is degraded by chlamydial protease-like activity factor (CPAF) in Chlamydia trachomatis-infected genital epithelial cells
    Microbes Infect (2009) 11, 12-19. PubMed  Europe PubMed DOI
    48. 2008
  48. Huang,Z., Feng,Y., Chen,D., Wu,X., Huang,S., Wang,X., Xiao,X., Li,W., Huang,N., Gu,L., Zhong,G. and Chai,J.
    Structural basis for activation and inhibition of the secreted chlamydia protease CPAF
    Cell Host Microbe (2008) 4, 529-542. PubMed  Europe PubMed DOI  S  T
  49. Kumar,Y. and Valdivia,R.H.
    Actin and intermediate filaments stabilize the Chlamydia trachomatis vacuole by forming dynamic structural scaffolds
    Cell Host Microbe (2008) 4, 159-169. PubMed  Europe PubMed DOI  PMC  EPMC
  50. Kumar,Y. and Valdivia,R.H.
    Reorganization of the host cytoskeleton by the intracellular pathogen Chlamydia trachomatis
    Commun Integr Biol (2008) 1, 175-177. PubMed  Europe PubMed  PMC  EPMC
  51. Paschen,S.A., Christian,J.G., Vier,J., Schmidt,F., Walch,A., Ojcius,D.M. and Hacker,G.
    Cytopathicity of Chlamydia is largely reproduced by expression of a single chlamydial protease
    J Cell Biol (2008) 182, 117-127. PubMed  Europe PubMed DOI  PMC  EPMC
  52. Savijoki,K., Alvesalo,J., Vuorela,P., Leinonen,M. and Kalkkinen,N.
    Proteomic analysis of Chlamydia pneumoniae-infected HL cells reveals extensive degradation of cytoskeletal proteins
    FEMS Immunol Med Microbiol (2008) 54, 375-384. PubMed  Europe PubMed DOI
  53. Zheng,J., Wu,Y., Liu,J., Liu,G. and Chen,C.
    [Early diagnosis using recombinant protein of immunodominant region gene of chlamydial protease-like activity factor from Chlamydophila pneumoniae]
    Wei Sheng Wu Xue Bao (2008) 48, 520-525. PubMed  Europe PubMed  E
    54. 2007
  54. Murthy,A.K., Chambers,J.P., Meier,P.A., Zhong,G. and Arulanandam,B.P.
    Intranasal vaccination with a secreted chlamydial protein enhances resolution of genital Chlamydia muridarum infection, protects against oviduct pathology, and is highly dependent upon endogenous gamma interferon production
    Infect Immun (2007) 75, 666-676. PubMed  Europe PubMed DOI  PMC  EPMC
    55. 2006
  55. Murphey,C., Murthy,A.K., Meier,P.A., Neal Guentzel,M., Zhong,G. and Arulanandam,B.P.
    The protective efficacy of chlamydial protease-like activity factor vaccination is dependent upon CD4+ T cells
    Cell Immunol (2006) 242, 110-117. PubMed  Europe PubMed DOI  PMC  EPMC
  56. [YEAR:2-10-2006]Murthy,A.K., Cong,Y., Murphey,C., Guentzel,M.N., Forsthuber,T.G., Zhong,G. and Arulanandam,B.P.
    Chlamydial protease-like activity factor induces protective immunity against genital chlamydial infection in transgenic mice that express the human HLA-DR4 allele
    Infect Immun (2-10-2006) 74, 6722-6729. PubMed  Europe PubMed DOI  PMC  EPMC
  57. [YEAR:28-8-2006]Pirbhai,M., Dong,F., Zhong,Y., Pan,K.Z. and Zhong,G.
    The secreted protease factor CPAF is responsible for degrading pro-apoptotic BH3-only proteins in Chlamydia trachomatis-infected cells
    J Biol Chem (28-8-2006) 281, 31495-31501. PubMed  Europe PubMed DOI
    58. 2005
  58. Dong,F., Zhong,Y., Arulanandam,B. and Zhong,G.
    Production of a proteolytically active protein, chlamydial protease/proteasome-like activity factor, by five different Chlamydia species
    Infect Immun (2005) 73, 1868-1872. PubMed  Europe PubMed DOI  PMC  EPMC
  59. Sharma,J., Dong,F., Pirbhai,M. and Zhong,G.
    Inhibition of proteolytic activity of a chlamydial proteasome/protease-like activity factor by antibodies from humans infected with Chlamydia trachomatis
    Infect Immun (2005) 73, 4414-4419. PubMed  Europe PubMed DOI  PMC  EPMC
    60. 2004
  60. Dong,F., Pirbhai,M., Zhong,Y. and Zhong,G.
    Cleavage-dependent activation of a chlamydia-secreted protease
    Mol Microbiol (2004) 52, 1487-1494. PubMed  Europe PubMed DOI
  61. Dong,F., Sharma,J., Xiao,Y., Zhong,Y. and Zhong,G.
    Intramolecular dimerization is required for the Chlamydia-secreted protease CPAF to degrade host transcriptional factors
    Infect Immun (2004) 72, 3869-3875. PubMed  Europe PubMed DOI  PMC  EPMC
  62. Dong,F., Su,H., Huang,Y., Zhong,Y. and Zhong,G.
    Cleavage of host keratin 8 by a Chlamydia-secreted protease
    Infect Immun (2004) 72, 3863-3868. PubMed  Europe PubMed DOI  PMC  EPMC
    63. 2003
  63. Heuer,D., Brinkmann,V., Meyer,T.F. and Szczepek,A.J.
    Expression and translocation of chlamydial protease during acute and persistent infection of the epithelial HEp-2 cells with Chlamydophila (Chlamydia) pneumoniae
    Cell Microbiol (2003) 5, 315-322. PubMed  Europe PubMed DOI
    64. 2002
  64. Fan,P., Dong,F., Huang,Y. and Zhong,G.
    Chlamydia pneumoniae secretion of a protease-like activity factor for degrading host cell transcription factors required for [correction of factors is required for] major histocompatibility complex antigen expression
    Infect Immun (2002) 70, 345-349. PubMed  Europe PubMed DOI  PMC  EPMC
  65. Shaw,A.C., Vandahl,B.B., Larsen,M.R., Roepstorff,P., Gevaert,K., Vandekerckhove,J., Christiansen,G. and Birkelund,S.
    Characterization of a secreted Chlamydia protease
    Cell Microbiol (2002) 4, 411-424. PubMed  Europe PubMed DOI
    66. 2001
  66. [YEAR:16-4-2001]Zhong,G., Fan,P., Ji,H., Dong,F. and Huang,Y.
    Identification of a chlamydial protease-like activity factor responsible for the degradation of host transcription factors
    J Exp Med (16-4-2001) 193, 935-942. PubMed  Europe PubMed DOI  PMC  EPMC

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