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Literature for peptidase S08.027: cell envelope peptidase A (Streptococcus-type)

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, P Specificity, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Giblin,S.P., McKenna,S., Matthews,S., Sriskandan,S. and Pease,J.E.<br>The N-terminal ELR(+) motif of the neutrophil attractant CXCL8 confers susceptibility to degradation by the Group A Streptococcal protease, SpyCEP<br>J Biol Chem (2025) , 108448-108448. PubMed  Europe PubMed DOI
    2. 2024
  2. Massai,L., Carducci,M., Rovetini,L., Paterson,A., Whitcombe,A., McGregor,R., Lorenz,N., Keeley,A.J., de Silva,T.I., Bennett,J., Berlanda Scorza,F., Iturriza,M., Moreland,N.J., Moriel,D.G. and Rossi,O.<br>Characterization of an IL-8 cleavage inhibition assay to determine the functionality of anti-SpyCEP antibodies in human sera<br>J Immunol Methods (2024) 536, 113786-113786. PubMed  Europe PubMed DOI
    3. 2023
  3. Christensen,L.F., Hoie,M.H., Bang-Berthelsen,C.H., Marcatili,P. and Hansen,E.B.<br>Comparative Structure Analysis of the Multi-Domain, Cell Envelope Proteases of Lactic Acid Bacteria<br>Microorganisms (2023) 11 PubMed  Europe PubMed DOI  PMC  EPMC
  4. Pearson,M., Haslam,C., Fosberry,A., Jones,E.J., Reglinski,M., Reeves,L., Edwards,R.J., Lawrenson,R.A., Brown,J.C., Mossakowska,D., Pease,J.E. and Sriskandan,S.<br>Structure-activity studies of Streptococcus pyogenes enzyme SpyCEP reveal high affinity for CXCL8 in the SpyCEP C-terminal<br>Sci Rep (2023) 13, 19052-19052. PubMed  Europe PubMed DOI  PMC  EPMC
    5. 2022
  5. Bergmann,R., Gulotta,G., Andreoni,F., Sumitomo,T., Kawabata,S., Zinkernagel,A.S., Chhatwal,G.S., Nizet,V., Rohde,M. and Uchiyama,S.<br>The group A Streptococcus interleukin-8 protease SpyCEP promotes bacterial intracellular survival by evasion of autophagy<br>Infect Microbes Dis (2022) 4, 116-123. PubMed  Europe PubMed DOI  PMC  EPMC
    6. 2021
  6. Awussi,A.A., Roux,E., Humeau,C., Hafeez,Z., Maigret,B., Chang,O.K., Lecomte,X., Humbert,G., Miclo,L., Genay,M., Perrin,C. and Dary-Mourot,A.<br>Role of the Sortase A in the Release of Cell-Wall Proteinase PrtS in the Growth Medium of Streptococcus thermophilus 4F44<br>Microorganisms (2021) 9 PubMed  Europe PubMed DOI  PMC  EPMC
  7. Biswas,D., Ambalavanan,P., Ravins,M., Anand,A., Sharma,A., Lim,K.X.Z., Tan,R.Y.M., Lim,H.Y., Sol,A., Bachrach,G., Angeli,V. and Hanski,E.<br>LL-37-mediated activation of host receptors is critical for defense against group A streptococcal infection<br>Cell Rep (2021) 34, 108766-108766. PubMed  Europe PubMed DOI
  8. Jobichen,C., Ying Chong,T., Hui Ling,T. and Sivaraman,J.<br>The Autocatalytic Cleavage Domain Is Not Required for the Activity of ScpC, a Virulence Protease from Streptococcus pyogenes: A Structural Insight<br>Biochemistry (2021) 60, 1564-1568. PubMed  Europe PubMed DOI
    9. 2020
  9. Boulay,M., Al Haddad,M. and Rul,F.<br>Streptococcus thermophilus growth in soya milk: Sucrose consumption, nitrogen metabolism, soya protein hydrolysis and role of the cell-wall protease PrtS<br>Int J Food Microbiol (2020) 335, 108903-108903. PubMed  Europe PubMed DOI
  10. McKenna,S., Malito,E., Rouse,S.L., Abate,F., Bensi,G., Chiarot,E., Micoli,F., Mancini,F., Gomes Moriel,D., Grandi,G., Mossakowska,D., Pearson,M., Xu,Y., Pease,J., Sriskandan,S., Margarit,I., Bottomley,M.J. and Matthews,S.<br>Structure, dynamics and immunogenicity of a catalytically inactive CXC chemokine-degrading protease SpyCEP from Streptococcus pyogenes<br>Comput Struct Biotechnol J (2020) 18, 650-660. PubMed  Europe PubMed DOI  PMC  EPMC  S
    11. 2019
  11. Goldblatt,J., Lawrenson,R.A., Muir,L., Dattani,S., Hoffland,A., Tsuchiya,T., Kanegasaki,S., Sriskandan,S. and Pease,J.E.<br>A requirement for neutrophil glycosaminoglycans in chemokine:receptor interactions is revealed by the streptococcal protease SpyCEP<br>J Immunol (2019) 202, 3246-3255. PubMed  Europe PubMed DOI
    12. 2018
  12. Jobichen,C., Tan,Y.C., Prabhakar,M.T., Nayak,D., Biswas,D., Pannu,N.S., Hanski,E. and Sivaraman,J.<br>Structure of ScpC, a virulence protease from Streptococcus pyogenes, reveals the functional domains and maturation mechanism<br>Biochem J (2018) 475, 2847-2860. PubMed  Europe PubMed DOI  S  I
  13. Rodriguez-Serrano,G.M., Garcia-Garibay,M., Cruz-Guerrero,A.E., Gomez-Ruiz,L., Ayala-Nino,A., Castaneda-Ovando,A. and Gonzalez-Olivares,L.G.<br>Proteolytic system of Streptococcus thermophilus<br>J Microbiol Biotechnol (2018) 28, 1581-1588. PubMed  Europe PubMed DOI  V
  14. Tian,H., Li,B., Evivie,S.E., Sarker,S.K., Chowdhury,S., Lu,J., Ding,X. and Huo,G.<br>Technological and genomic analysis of roles of the cell-envelope protease PrtS in yoghurt starter development<br>Int J Mol Sci (2018) 19 DOI
    15. 2017
  15. Bassi,D., Cappa,F., Gazzola,S., Orru,L. and Cocconcelli,P.S.<br>Biofilm formation on stainless steel in milk environment is mediated by the proteinase PrtS in Streptococcus thermophilus UC8547<br>Appl Environ Microbiol (2017) 83, e02840-16-e02840-16. PubMed  Europe PubMed DOI
    16. 2016
  16. Huang,X., Palmer,S.R., Ahn,S.J., Richards,V.P., Williams,M.L., Nascimento,M.M. and Burne,R.A.<br>A highly arginolytic Streptococcus species that potently antagonizes Streptococcus mutans<br>Appl Environ Microbiol (2016) 82, 2187-2201. PubMed  Europe PubMed DOI
  17. Pandey,M., Mortensen,R., Calcutt,A., Powell,J., Batzloff,M.R., Dietrich,J. and Good,M.F.<br>Combinatorial synthetic peptide vaccine strategy protects against hypervirulent CovR/S mutant streptococci<br>J Immunol (2016) 196, 3364-3374. PubMed  Europe PubMed DOI
  18. Yin,S., Li,M., Rao,X., Yao,X., Zhong,Q., Wang,M., Wang,J., Peng,Y., Tang,J., Hu,F. and Zhao,Y.<br>Subtilisin-like protease-1 secreted through type IV secretion system contributes to high virulence of Streptococcus suis 2<br>Sci Rep (2016) 6, 27369-27369. PubMed  Europe PubMed DOI  PMC  EPMC
    19. 2014
  19. Andreoni,F., Ogawa,T., Ogawa,M., Madon,J., Uchiyama,S., Schuepbach,R.A. and Zinkernagel,A.S.<br>The IL-8 protease SpyCEP is detrimental for Group A Streptococcus host-cells interaction and biofilm formation<br>Front Microbiol (2014) 5, 339-339. PubMed  Europe PubMed DOI  PMC  EPMC
  20. Chang,O.K., Roux,E., Awussi,A.A., Miclo,L., Jardin,J., Jameh,N., Dary,A., Humbert,G. and Perrin,C.<br>Use of a free form of the Streptococcus thermophilus cell envelope protease PrtS as a tool to produce bioactive peptides<br>Int Dairy J (2014) 38, 104-115. DOI
    21. 2013
  21. Abate,F., Malito,E., Falugi,F., Margarit,Y.R. and Bottomley,M.J.<br>Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of SpyCEP, a candidate antigen for a vaccine against Streptococcus pyogenes<br>Acta Crystallogr Sect F Struct Biol Cryst Commun (2013) 69, 1103-1106. PubMed  Europe PubMed DOI  PMC  EPMC
    22. 2012
  22. Chang,O.K., Perrin,C., Galia,W., Saulnier,F., Miclo,L., Roux,E., Driou,A., Humbert,G. and Dary,A.<br>Release of the cell-envelope protease PrtS in the growth medium of Streptococcus thermophilus 4F44<br>Int Dairy J (2012) 23, 91-98. DOI
  23. Harty,D.W., Farahani,R.M., Simonian,M.R., Hunter,L. and Hunter,N.<br>Streptococcus gordonii FSS2 challisin affects fibrin clot formation by digestion of the alphaC region and cleavage of the N-terminal region of the Bbeta chains of fibrinogen<br>Thromb Haemost (2012) 108, 236-246. PubMed  Europe PubMed DOI
  24. Lawrenson,R.A. and Sriskandan,S.<br>Cell envelope proteinase A (Streptococcus)<br>[ISSN:978-0-12-407742-3] (2012) 3, 3195-3202. DOI
    25. 2011
  25. Bonifait,L., Vaillancourt,K., Gottschalk,M., Frenette,M. and Grenier,D.<br>Purification and characterization of the subtilisin-like protease of Streptococcus suis that contributes to its virulence<br>Vet Microbiol (2011) 148, 333-340. PubMed  Europe PubMed DOI
  26. Bonifait,L. and Grenier,D.<br>The SspA subtilisin-like protease of Streptococcus suis triggers a pro-inflammatory response in macrophages through a non-proteolytic mechanism<br>BMC Microbiol (2011) 11, 47-47. PubMed  Europe PubMed DOI
  27. Dandoy,D., Fremaux,C., Henry de Frahan,M., Horvath,P., Boyaval,P., Hols,P. and Fontaine,L.<br>The fast milk acidifying phenotype of Streptococcus thermophilus can be acquired by natural transformation of the genomic island encoding the cell-envelope proteinase PrtS<br>Microb Cell Fact (2011) 10 Suppl 1, S21-S21. PubMed  Europe PubMed DOI
  28. Harty,D.W. and Hunter,N.<br>Carboxypeptidase activity common to viridans group streptococci cleaves angiotensin I to angiotensin II: an activity homologous to angiotensin-converting enzyme (ACE)<br>Microbiology (Reading) (2011) 157, 2143-2151. PubMed  Europe PubMed DOI
    29. 2010
  29. Bonifait,L., de la Cruz Dominguez-Punaro, Vaillancourt,K., Bart,C., Slater,J., Frenette,M., Gottschalk,M. and Grenier,D.<br>The cell envelope subtilisin-like proteinase is a virulence determinant for Streptococcus suis<br>BMC Microbiol (2010) 10, 42-42. PubMed  Europe PubMed DOI
  30. Delorme,C., Bartholini,C., Bolotine,A., Ehrlich,S.D. and Renault,P.<br>Emergence of a cell wall protease in the Streptococcus thermophilus population<br>Appl Environ Microbiol (2010) 76, 451-460. PubMed  Europe PubMed DOI
  31. Hu,Q., Liu,P., Yu,Z., Zhao,G., Li,J., Teng,L., Zhou,M., Bei,W., Chen,H. and Jin,M.<br>Identification of a cell wall-associated subtilisin-like serine protease involved in the pathogenesis of Streptococcus suis serotype 2<br>Microb Pathog (2010) 48, 103-109. PubMed  Europe PubMed DOI
  32. Kaur,S.J., Nerlich,A., Bergmann,S., Rohde,M., Fulde,M., Zahner,D., Hanski,E., Zinkernagel,A., Nizet,V., Chhatwal,G.S. and Talay,S.R.<br>The CXC chemokine-degrading protease SpyCep of Streptococcus pyogenes promotes its uptake into endothelial cells<br>J Biol Chem (2010) 285, 27798-27805. PubMed  Europe PubMed DOI
  33. Kurupati,P., Turner,C.E., Tziona,I., Lawrenson,R.A., Alam,F.M., Nohadani,M., Stamp,G.W., Zinkernagel,A.S., Nizet,V., Edwards,R.J. and Sriskandan,S.<br>Chemokine-cleaving Streptococcus pyogenes protease SpyCEP is necessary and sufficient for bacterial dissemination within soft tissues and the respiratory tract<br>Mol Microbiol (2010) 76, 1387-1397. PubMed  Europe PubMed DOI
  34. Zingaretti,C., Falugi,F., Nardi-Dei,V., Pietrocola,G., Mariani,M., Liberatori,S., Gallotta,M., Tontini,M., Tani,C., Speziale,P., Grandi,G. and Margarit,I.<br>Streptococcus pyogenes SpyCEP: a chemokine-inactivating protease with unique structural and biochemical features<br>FASEB J (2010) 24, 2839-2848. PubMed  Europe PubMed DOI  E
    35. 2009
  35. Bryan,J.D. and Shelver,D.W.<br>Streptococcus agalactiae CspA is a serine protease that inactivates chemokines<br>J Bacteriol (2009) 191, 1847-1854. PubMed  Europe PubMed DOI  PMC  EPMC
  36. Fritzer,A., Noiges,B., Schweiger,D., Rek,A., Kungl,A.J., von Gabain,A., Nagy,E. and Meinke,A.L.<br>Chemokine degradation by the Group A streptococcal serine proteinase ScpC can be reconstituted in vitro and requires two separate domains<br>Biochem J (2009) 422, 533-542. PubMed  Europe PubMed DOI
  37. Turner,C.E., Kurupati,P., Jones,M.D., Edwards,R.J. and Sriskandan,S.<br>Emerging role of the interleukin-8 cleaving enzyme SpyCEP in clinical Streptococcus pyogenes infection<br>J Infect Dis (2009) 200, 555-563. PubMed  Europe PubMed DOI
  38. Turner,C.E., Kurupati,P., Wiles,S., Edwards,R.J. and Sriskandan,S.<br>Impact of immunization against SpyCEP during invasive disease with two streptococcal species: Streptococcus pyogenes and Streptococcus equi<br>Vaccine (2009) 27, 4923-4929. PubMed  Europe PubMed DOI  PMC  EPMC
    39. 2008
  39. Shelver,D. and Bryan,J.D.<br>Expression of the Streptococcus agalactiae virulence-associated protease CspA in a soluble, active form utilizing the Gram-positive host, Lactococcus lactis<br>J Biotechnol (2008) 136, 129-134. PubMed  Europe PubMed DOI  E
  40. Sjolinder,H., Lovkvist,L., Plant,L., Eriksson,J., Aro,H., Jones,A. and Jonsson,A.B.<br>The ScpC protease of Streptococcus pyogenes affects the outcome of sepsis in a murine model<br>Infect Immun (2008) 76, 3959-3966. PubMed  Europe PubMed DOI  PMC  EPMC
  41. Sumby,P., Zhang,S., Whitney,A.R., Falugi,F., Grandi,G., Graviss,E.A., DeLeo,F.R. and Musser,J.M.<br>A chemokine-degrading extracellular protease made by group A Streptococcus alters pathogenesis by enhancing evasion of the innate immune response<br>Infect Immun (2008) 76, 978-985. PubMed  Europe PubMed DOI  PMC  EPMC
  42. Zinkernagel,A.S., Timmer,A.M., Pence,M.A., Locke,J.B., Buchanan,J.T., Turner,C.E., Mishalian,I., Sriskandan,S., Hanski,E. and Nizet,V.<br>The IL-8 protease SpyCEP/ScpC of group A Streptococcus promotes resistance to neutrophil killing<br>Cell Host Microbe (2008) 4, 170-178. PubMed  Europe PubMed DOI  PMC  EPMC
    43. 2006
  43. [YEAR:14-9-2006]Hidalgo-Grass,C., Mishalian,I., Dan-Goor,M., Belotserkovsky,I., Eran,Y., Nizet,V., Peled,A. and Hanski,E.<br>A streptococcal protease that degrades CXC chemokines and impairs bacterial clearance from infected tissues<br>EMBO J (14-9-2006) 25, 4628-4637. PubMed  Europe PubMed DOI
    44. 2005
  44. Edwards,R.J., Taylor,G.W., Ferguson,M., Murray,S., Rendell,N., Wrigley,A., Bai,Z., Boyle,J., Finney,S.J., Jones,A., Russell,H.H., Turner,C., Cohen,J., Faulkner,L. and Sriskandan,S.<br>Specific C-terminal cleavage and inactivation of interleukin-8 by invasive disease isolates of Streptococcus pyogenes<br>J Infect Dis (2005) 192, 783-790. PubMed  Europe PubMed DOI  P
    45. 2002
  45. Courtin,P., Monnet,V. and Rul,F.<br>Cell-wall proteinases PrtS and PrtB have a different role in Streptococcus thermophilus/Lactobacillus bulgaricus mixed cultures in milk<br>Microbiology (Reading, Engl.) (2002) 148, 3413-3421. PubMed  Europe PubMed
    46. 2000
  46. Fernandez-Espla,M.D., Garault,P., Monnet,V. and Rul,F.<br>Streptococcus thermophilus cell wall-anchored proteinase: release, purification, and biochemical and genetic characterization<br>Appl Environ Microbiol (2000) 66, 4772-4778. PubMed  Europe PubMed DOI  PMC  EPMC

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