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Literature for peptidase S01.251: kallikrein-related peptidase 4

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors Pharma

(Topics flags: A Assay, S Structure, T Target, K Knockout, P Specificity, V Review, M Mutation, R Splicing, I Inhibitor. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Afratis,N.A., Riley,B.T., Chandler,P.G., Buckle,A.M. and Sagi,I.
    Allosteric Anti-KLK4 Antibody Development for Targeted Anti-Cancer Effects in Ovarian Carcinoma
    J Mol Biol (2025) , 169101-169101. PubMed  Europe PubMed DOI
    2. 2023
  2. Lehto,T.K., Kovanen,R.M., Lintula,S., Malen,A., Sturenberg,C., Erickson,A., Pulkka,O.P., Stenman,U.H., Diamandis,E.P., Rannikko,A., Mirtti,T. and Koistinen,H.
    Prognostic impact of kallikrein-related peptidase transcript levels in prostate cancer
    Int J Cancer (2023) 153, 867-881. PubMed  Europe PubMed DOI
  3. Li,Y., Zhang,L., Cen,W. and Yuan,Y.
    Association of KLK4 rs2235091 polymorphism with susceptibility to dental caries: a systematic review and meta-analysis
    Front Pediatr (2023) 11, 1236000-1236000. PubMed  Europe PubMed DOI  PMC  EPMC
    4. 2021
  4. Aydin,E.B., Aydin,M., Yuzer,A., Ince,M., Ocakoglu,K. and Sezginturk,M.K.
    Detection of Kallikrein-Related Peptidase 4 with a Label-free Electrochemical Impedance Biosensor Based on a Zinc(II) Phthalocyanine Tetracarboxylic Acid-Functionalized Disposable Indium Tin Oxide Electrode
    ACS Biomater Sci Eng (2021) 7, 1192-1201. PubMed  Europe PubMed DOI
  5. Li,M., Srp,J., Mares,M., Wlodawer,A. and Gustchina,A.
    Structural studies of complexes of kallikrein 4 with wild-type and mutated forms of the Kunitz-type inhibitor BbKI
    Acta Crystallogr D Struct Biol (2021) 77, 1084-1098. PubMed  Europe PubMed DOI  PMC  EPMC
  6. Rabinovitch,E., Mihara,K., Sananes,A., Zaretsky,M., Heyne,M., Shifman,J., Aharoni,A., Hollenberg,M.D. and Papo,N.
    A KLK4 proteinase substrate capture approach to antagonize PAR1
    Sci Rep (2021) 11, 16170-16170. PubMed  Europe PubMed DOI  PMC  EPMC
    7. 2020
  7. Gao,J., Li,X., Gao,L., Chen,H., Baras,B.H., Liu,X., Liu,H., Rana,A., Gao,M. and Ruan,J.
    Effects of applying amoxicillin in juvenile mice on enamel mineralization and the expression of kallikreinrelated peptidase 4 and tight junction proteins in ameloblasts
    Int J Mol Med (2020) 46, 179-190. PubMed  Europe PubMed DOI  PMC  EPMC
  8. Tse,B.W., Kryza,T., Yeh,M.C., Dong,Y., Sokolowski,K.A., Walpole,C., Dreyer,T., Felber,J., Harris,J., Magdolen,V., Russell,P.J. and Clements,J.A.
    KLK4 Induces Anti-Tumor Effects in Human Xenograft Mouse Models of Orthotopic and Metastatic Prostate Cancer
    Cancers (Basel) (2020) 12 PubMed  Europe PubMed DOI
  9. Wang,J., Yao,X., Wu,D.L. and Jin,Y.
    Kallikrein-related peptidase 4 promotes migration and invasion of endometrial stromal cells in endometriosis by inducing epithelial-mesenchymal transition
    J Biol Regul Homeost Agents (2020) 34, 93-100. PubMed  Europe PubMed DOI
    10. 2019
  10. Li,M., Srp,J., Gustchina,A., Dauter,Z., Mares,M. and Wlodawer,A.
    Crystal structures of the complex of a kallikrein inhibitor from Bauhinia bauhinioides with trypsin and modeling of kallikrein complexes
    Acta Crystallogr D Struct Biol (2019) 75, 56-69. PubMed  Europe PubMed DOI  S
  11. Riley,B.T., Ilyichova,O., de Veer,S.J., Swedberg,J.E., Wilson,E., Hoke,D.E., Harris,J.M. and Buckle,A.M.
    KLK4 Inhibition by cyclic and acyclic peptides: structural and dynamical insights into standard-mechanism protease inhibitors
    Biochemistry (2019) 58, 2524-2533. PubMed  Europe PubMed DOI
  12. Riley,B.T., Hoke,D.E., McGowan,S. and Buckle,A.M.
    Crystal structure of the inhibitor-free form of the serine protease kallikrein-4
    Acta Crystallogr F Struct Biol Commun (2019) 75, 543-546. PubMed  Europe PubMed DOI  S
    13. 2018
  13. Loessner,D., Goettig,P., Preis,S., Felber,J., Bronger,H., Clements,J.A., Dorn,J. and Magdolen,V.
    Kallikrein-related peptidases represent attractive therapeutic targets for ovarian cancer
    Expert Opin Ther Targets (2018) 22, 745-763. PubMed  Europe PubMed DOI  T
  14. Perez,V.A., Mangum,J.E. and Hubbard,M.J.
    Direct evidence that KLK4 is a hydroxyapatite-binding protein
    Biochem Biophys Res Commun (2018) 495, 1896-1900. PubMed  Europe PubMed DOI
  15. Swedberg,J.E., Ghani,H.A., Harris,J.M., de Veer,S.J. and Craik,D.J.
    Potent, selective, and cell-penetrating inhibitors of kallikrein-related peptidase 4 based on the cyclic peptide MCoTI-II
    ACS Med Chem Lett (2018) 9, 1258-1262. PubMed  Europe PubMed DOI  PMC  EPMC
    16. 2017
  16. Reid,J.C., Matsika,A., Davies,C.M., He,Y., Broomfield,A., Bennett,N.C., Magdolen,V., Srinivasan,B., Clements,J.A. and Hooper,J.D.
    Pericellular regulation of prostate cancer expressed kallikrein-related peptidases and matrix metalloproteinases by cell surface serine proteases
    Am J Cancer Res (2017) 7, 2257-2274. PubMed  Europe PubMed  PMC  EPMC
  17. Smith,C.E.L., Kirkham,J., Day,P.F., Soldani,F., McDerra,E.J., Poulter,J.A., Inglehearn,C.F., Mighell,A.J. and Brookes,S.J.
    A fourth KLK4 mutation is associated with enamel hypomineralisation and structural abnormalities
    Front Physiol (2017) 8, 333-333. PubMed  Europe PubMed DOI  PMC  EPMC  M
    18. 2016
  18. Fuhrman-Luck,R.A., Stansfield,S.H., Stephens,C.R., Loessner,D. and Clements,J.A.
    Prostate cancer-associated kallikrein-related peptidase 4 activates matrix metalloproteinase-1 and thrombospondin-1
    J Proteome Res (2016) 15, 2466-2478. PubMed  Europe PubMed DOI  P
  19. Karakosta,T.D., Soosaipillai,A., Diamandis,E.P., Batruch,I. and Drabovich,A.P.
    Quantification of human kallikrein-related peptidases in biological fluids by multiplatform targeted mass spectrometry assays
    Mol Cell Proteomics (2016) 15, 2863-2876. PubMed  Europe PubMed DOI  A
  20. Riley,B.T., Ilyichova,O., Costa,M.G., Porebski,B.T., de Veer,S.J., Swedberg,J.E., Kass,I., Harris,J.M., Hoke,D.E. and Buckle,A.M.
    Direct and indirect mechanisms of KLK4 inhibition revealed by structure and dynamics
    Sci Rep (2016) 6, 35385-35385. PubMed  Europe PubMed DOI  PMC  EPMC  S
    21. 2015
  21. Lisle,J.E., Mertens-Walker,I., Stephens,C.R., Stansfield,S.H., Clements,J.A., Herington,A.C. and Stephenson,S.A.
    Murine, but not human, ephrin-B2 can be efficiently cleaved by the serine protease kallikrein-4: implications for xenograft models of human prostate cancer
    Exp Cell Res (2015) 333, 136-146. PubMed  Europe PubMed DOI
    22. 2014
  22. Bartlett,J.D. and Simmer,J.P.
    Kallikrein-related peptidase-4 (KLK4): role in enamel formation and revelations from ablated mice
    Front Physiol (2014) 5, 240-240. PubMed  Europe PubMed DOI  PMC  EPMC
  23. Kawasaki,K., Hu,J.C. and Simmer,J.P.
    Evolution of Klk4 and enamel maturation in eutherians
    Biol Chem (2014) 395, 1003-1013. PubMed  Europe PubMed DOI
    24. 2013
  24. Jin,Y., Qu,S., Tesikova,M., Wang,L., Kristian,A., Maelandsmo,G.M., Kong,H., Zhang,T., Jeronimo,C., Teixeira,M.R., Yuca,E., Tekedereli,I., Gorgulu,K., Alpay,N., Sood,A.K., Lopez-Berestein,G., Danielsen,H.E., Ozpolat,B. and Saatcioglu,F.
    Molecular circuit involving KLK4 integrates androgen and mTOR signaling in prostate cancer
    Proc Natl Acad Sci U S A (2013) 110, E2572-E2581. PubMed  Europe PubMed DOI
  25. Lundwall,A.
    Old genes and new genes: The evolution of the kallikrein locus
    Thromb Haemost (2013) 110, 469-475. PubMed  Europe PubMed DOI  V
  26. Wang,S.K., Hu,Y., Simmer,J.P., Seymen,F., Estrella,N.M.R.P., Pal,S., Reid,B.M., Yildirim,M., Bayram,M., Bartlett,J.D. and Hu,J.C.C.
    Novel KLK4 and MMP20 mutations discovered by whole-exome sequencing
    J Dent Res (2013) 92, 266-271. PubMed  Europe PubMed DOI  M
    27. 2012
  27. Simmer,J.P.
    Kallikrein-related peptidase 4
    [ISSN:978-0-12-407742-3] (2012) 3, 2768-2772. DOI
    28. 2011
  28. Hu,Y., Hu,J.C., Smith,C.E., Bartlett,J.D. and Simmer,J.P.
    Kallikrein-related peptidase 4, matrix metalloproteinase 20, and the maturation of murine and porcine enamel
    Eur J Oral Sci (2011) 119 Suppl 1, 217-225. PubMed  Europe PubMed DOI
  29. Simmer,J.P., Hu,Y., Richardson,A.S., Bartlett,J.D. and Hu,J.C.
    Why does enamel in Klk4-null mice break above the dentino-enamel junction?
    Cells Tissues Organs (2011) 194, 211-215. PubMed  Europe PubMed DOI  K
  30. Smith,C.E., Richardson,A.S., Hu,Y., Bartlett,J.D., Hu,J.C. and Simmer,J.P.
    Effect of kallikrein 4 loss on enamel mineralization: comparison with mice lacking matrix metalloproteinase 20
    J Biol Chem (2011) 286, 18149-18160. PubMed  Europe PubMed DOI
  31. Yamakoshi,Y., Yamakoshi,F., Hu,J.C. and Simmer,J.P.
    Characterization of kallikrein-related peptidase 4 glycosylations
    Eur J Oral Sci (2011) 119 Suppl 1, 234-240. PubMed  Europe PubMed DOI
  32. Yamakoshi,Y., Richardson,A.S., Nunez,S.M., Yamakoshi,F., Milkovich,R.N., Hu,J.C., Bartlett,J.D. and Simmer,J.P.
    Enamel proteins and proteases in Mmp20 and Klk4 null and double-null mice
    Eur J Oral Sci (2011) 119 Suppl 1, 206-216. PubMed  Europe PubMed DOI  K
    33. 2010
  33. Angelopoulou,K. and Karagiannis,G.S.
    Structural characterization and expression of five novel canine kallikrein-related peptidases in mammary cancer
    Mamm Genome (2010) 21, 516-524. PubMed  Europe PubMed DOI
  34. Gratio,V., Beaufort,N., Seiz,L., Maier,J., Virca,G.D., Debela,M., Grebenchtchikov,N., Magdolen,V. and Darmoul,D.
    Kallikrein-related peptidase 4: a new activator of the aberrantly expressed protease-activated receptor 1 in colon cancer cells
    Am J Pathol (2010) 176, 1452-1461. PubMed  Europe PubMed DOI
  35. Wang,W., Mize,G.J., Zhang,X. and Takayama,T.K.
    Kallikrein-related peptidase-4 initiates tumor-stroma interactions in prostate cancer through protease-activated receptor-1
    Int J Cancer (2010) 126, 599-610. PubMed  Europe PubMed DOI
    36. 2009
  36. Nagano,T., Kakegawa,A., Yamakoshi,Y., Tsuchiya,S., Hu,J.C., Gomi,K., Arai,T., Bartlett,J.D. and Simmer,J.P.
    Mmp-20 and Klk4 cleavage site preferences for amelogenin sequences
    J Dent Res (2009) 88, 823-828. PubMed  Europe PubMed DOI  PMC  EPMC  P
  37. Swedberg,J.E., Nigon,L.V., Reid,J.C., de Veer,S.J., Walpole,C.M., Stephens,C.R., Walsh,T.P., Takayama,T.K., Hooper,J.D., Clements,J.A., Buckle,A.M. and Harris,J.M.
    Substrate-guided design of a potent and selective kallikrein-related peptidase inhibitor for kallikrein 4
    Chem Biol (2009) 16, 633-643. PubMed  Europe PubMed DOI  I
  38. Tye,C.E., Pham,C.T., Simmer,J.P. and Bartlett,J.D.
    DPPI may activate KLK4 during enamel formation
    J Dent Res (2009) 88, 323-327. PubMed  Europe PubMed DOI  PMC  EPMC
    39. 2008
  39. Clements,J.A.
    Reflections on the tissue kallikrein and kallikrein-related peptidase family - from mice to men - what have we learnt in the last two decades?
    Biol Chem (2008) 389, 1447-1454. PubMed  Europe PubMed DOI  V
  40. Debela,M., Beaufort,N., Magdolen,V., Schechter,N.M., Craik,C.S., Schmitt,M., Bode,W. and Goettig,P.
    Structures and specificity of the human kallikrein-related peptidases KLK 4, 5, 6, and 7
    Biol Chem (2008) 389, 623-632. PubMed  Europe PubMed DOI  P  S
  41. Lu,Y., Papagerakis,P., Yamakoshi,Y., Hu,J.C., Bartlett,J.D. and Simmer,J.P.
    Functions of KLK4 and MMP-20 in dental enamel formation
    Biol Chem (2008) 389, 695-700. PubMed  Europe PubMed DOI  PMC  EPMC
  42. Mukai,S., Fukushima,T., Naka,D., Tanaka,H., Osada,Y. and Kataoka,H.
    Activation of hepatocyte growth factor activator zymogen (pro-HGFA) by human kallikrein 1-related peptidases
    FEBS J (2008) 275, 1003-1017. PubMed  Europe PubMed DOI
  43. Ramsay,A.J., Dong,Y., Hunt,M.L., Linn,M., Samaratunga,H., Clements,J.A. and Hooper,J.D.
    Kallikrein-related peptidase 4 (KLK4) initiates intracellular signaling via protease-activated receptors (PARs). KLK4 and PAR-2 are co-expressed during prostate cancer progression
    J Biol Chem (2008) 283, 12293-12304. PubMed  Europe PubMed DOI
    44. 2007
  44. Borgono,C.A., Gavigan,J.A., Alves,J., Bowles,B., Harris,J.L., Sotiropoulou,G. and Diamandis,E.P.
    Defining the extended substrate specificity of kallikrein 1-related peptidases
    Biol Chem (2007) 388, 1215-1225. PubMed  Europe PubMed DOI  P
  45. Fernando,S.C., Najar,F.Z., Guo,X., Zhou,L., Fu,Y., Geisert,R.D., Roe,B.A. and DeSilva,U.
    Porcine kallikrein gene family: genomic structure, mapping, and differential expression analysis
    Genomics (2007) 89, 429-438. PubMed  Europe PubMed DOI
  46. Klokk,T.I., Kilander,A., Xi,Z., Waehre,H., Risberg,B., Danielsen,H.E. and Saatcioglu,F.
    Kallikrein 4 is a proliferative factor that is overexpressed in prostate cancer
    Cancer Res (2007) 67, 5221-5230. PubMed  Europe PubMed DOI
  47. Lawrence,M.G., Veveris-Lowe,T.L., Whitbread,A.K., Nicol,D.L. and Clements,J.A.
    Epithelial-mesenchymal transition in prostate cancer and the potential role of kallikrein serine proteases
    Cells Tissues Organs (2007) 185, 111-115. PubMed  Europe PubMed DOI
  48. Yoon,H., Laxmikanthan,G., Lee,J., Blaber,S.I., Rodriguez,A., Kogot,J.M., Scarisbrick,I.A. and Blaber,M.
    Activation profiles and regulatory cascades of the human kallikrein-related peptidases
    J Biol Chem (2007) 282, 31852-31864. PubMed  Europe PubMed DOI  V
    49. 2006
  49. Beaufort,N., Debela,M., Creutzburg,S., Kellermann,J., Bode,W., Schmitt,M., Pidard,D. and Magdolen,V.
    Interplay of human tissue kallikrein 4 (hK4) with the plasminogen activation system: hK4 regulates the structure and functions of the urokinase-type plasminogen activator receptor (uPAR)
    Biol Chem (2006) 387, 217-222. PubMed  Europe PubMed DOI
  50. [YEAR:1-6-2006]Debela,M., Magdolen,V., Schechter,N., Valachova,M., Lottspeich,F., Craik,C.S., Choe,Y., Bode,W. and Goettig,P.
    Specificity profiling of seven human tissue kallikreins reveals individual subsite preferences
    J Biol Chem (1-6-2006) 281, 25678-25688. PubMed  Europe PubMed DOI  P
  51. [YEAR:3-8-2006]Debela,M., Magdolen,V., Grimminger,V., Sommerhoff,C., Messerschmidt,A., Huber,R., Friedrich,R., Bode,W. and Goettig,P.
    Crystal structures of human tissue kallikrein 4: activity modulation by a specific zinc binding site
    J Mol Biol (3-8-2006) 362, 1094-1107. PubMed  Europe PubMed DOI  S
  52. Obiezu,C.V., Michael,I.P., Levesque,M.A. and Diamandis,E.P.
    Human kallikrein 4: enzymatic activity, inhibition, and degradation of extracellular matrix proteins
    Biol Chem (2006) 387, 749-759. PubMed  Europe PubMed DOI
  53. Prezas,P., Arlt,M.J., Viktorov,P., Soosaipillai,A., Holzscheiter,L., Schmitt,M., Talieri,M., Diamandis,E.P., Kruger,A. and Magdolen,V.
    Overexpression of the human tissue kallikrein genes KLK4, 5, 6, and 7 increases the malignant phenotype of ovarian cancer cells
    Biol Chem (2006) 387, 807-811. PubMed  Europe PubMed DOI
  54. Wright,J.T., Daly,B., Simmons,D., Hong,S., Hart,S.P., Hart,T.C., Atsawasuwan,P. and Yamauchi,M.
    Human enamel phenotype associated with amelogenesis imperfecta and a kallikrein-4 (g.2142G>A) proteinase mutation
    Eur J Oral Sci (2006) 114 Suppl 1, 13-17. PubMed  Europe PubMed DOI
  55. Yamakoshi,Y., Hu,J.C., Fukae,M., Yamakoshi,F. and Simmer,J.P.
    How do enamelysin and kallikrein 4 process the 32-kDa enamelin?
    Eur J Oral Sci (2006) 114 Suppl 1, 45-51. PubMed  Europe PubMed DOI
    56. 2005
  56. Davidson,B., Xi,Z., Klokk,T.I., Trope,C.G., Dorum,A., Scheistroen,M. and Saatcioglu,F.
    Kallikrein 4 expression is up-regulated in epithelial ovarian carcinoma cells in effusions
    Am J Clin Pathol (2005) 123, 360-368. PubMed  Europe PubMed DOI
  57. [YEAR:25-5-2005]Kurlender,L., Borgono,C., Michael,I.P., Obiezu,C., Elliott,M.B., Yousef,G.M. and Diamandis,E.P.
    A survey of alternative transcripts of human tissue kallikrein genes
    Biochim Biophys Acta (25-5-2005) 1755, 1-14. PubMed  Europe PubMed DOI  R
  58. [YEAR:22-4-2005]Matsumura,M., Bhatt,A.S., Andress,D., Clegg,N., Takayama,T.K., Craik,C.S. and Nelson,P.S.
    Substrates of the prostate-specific serine protease prostase/KLK4 defined by positional-scanning peptide libraries
    Prostate (22-4-2005) 62, 1-13. PubMed  Europe PubMed DOI  P
  59. [YEAR:13-1-2005]Michael,I.P., Kurlender,L., Memari,N., Yousef,G.M., Du,D., Grass,L., Stephan,C., Jung,K. and Diamandis,E.P.
    Intron retention: a common splicing event within the human kallikrein gene family
    Clin Chem (13-1-2005) 51, 506-515. PubMed  Europe PubMed DOI  R
  60. [YEAR:16-6-2005]Obiezu,C.V., Shan,S.J., Soosaipillai,A., Luo,L.Y., Grass,L., Sotiropoulou,G., Petraki,C.D., Papanastasiou,P.A., Levesque,M.A. and Diamandis,E.P.
    Human kallikrein 4: quantitative study in tissues and evidence for its secretion into biological fluids
    Clin Chem (16-6-2005) 51, 1432-1442. PubMed  Europe PubMed DOI
  61. Veveris-Lowe,T.L., Lawrence,M.G., Collard,R.L., Bui,L., Herington,A.C., Nicol,D.L. and Clements,J.A.
    Kallikrein 4 (hK4) and prostate-specific antigen (PSA) are associated with the loss of E-cadherin and an epithelial-mesenchymal transition (EMT)-like effect in prostate cancer cells
    Endocr Relat Cancer (2005) 12, 631-643. PubMed  Europe PubMed DOI
    62. 2004
  62. Clements,J.A., Hooper,J.D., Odorico,D.M. and Dong,Y.
    The tissue kallikrein gene cluster
    [ISSN:0-12-079610-4] (2004) 2, 1569-1577.  V
  63. Hart,P.S., Hart,T.C., Michalec,M.D., Ryu,O.H., Simmons,D., Hong,S. and Wright,J.T.
    Mutation in kallikrein 4 causes autosomal recessive hypomaturation amelogenesis imperfecta
    J Med Genet (2004) 41, 545-549. PubMed  Europe PubMed  PMC  EPMC
  64. Simmer,J.P.
    Prostase
    [ISSN:0-12-079610-4] (2004) 2, 1612-1614.  V
  65. [YEAR:15-11-2004]Simmer,J.P. and Bartlett,J.D.
    Kallikrein 4 is a secreted protein
    Cancer Res (15-11-2004) 64, 8481-8482. PubMed  Europe PubMed DOI
  66. Xi,Z., Kaern,J., Davidson,B., Klokk,T.I., Risberg,B., Trope,C. and Saatcioglu,F.
    Kallikrein 4 is associated with paclitaxel resistance in ovarian cancer
    Gynecol Oncol (2004) 94, 80-85. PubMed  Europe PubMed DOI
  67. [YEAR:1-4-2004]Xi,Z., Klokk,T.I., Korkmaz,K., Kurys,P., Elbi,C., Risberg,B., Danielsen,H., Loda,M. and Saatcioglu,F.
    Kallikrein 4 is a predominantly nuclear protein and is overexpressed in prostate cancer
    Cancer Res (1-4-2004) 64, 2365-2370. PubMed  Europe PubMed DOI
    68. 2003
  68. Harvey,T.J., Dong,Y., Bui,L., Jarrott,R., Walsh,T. and Clements,J.A.
    Production and characterization of antipeptide kallikrein 4 antibodies. Use of computer modeling to design peptides specific to kallikrein 4
    Methods Mol Med (2003) 81, 241-254. PubMed  Europe PubMed DOI
    69. 2002
  69. [YEAR:1-7-2002]Hural,J.A., Friedman,R.S., McNabb,A., Steen,S.S., Henderson,R.A. and Kalos,M.
    Identification of naturally processed CD4 T cell epitopes from the prostate-specific antigen kallikrein 4 using peptide-based in vitro stimulation
    J Immunol (1-7-2002) 169, 557-565. PubMed  Europe PubMed
  70. Ryu,O., Hu,J.C., Yamakoshi,Y., Villemain,J.L., Cao,X., Zhang,C., Bartlett,J.D. and Simmer,J.P.
    Porcine kallikrein-4 activation, glycosylation, activity, and expression in prokaryotic and eukaryotic hosts
    Eur J Oral Sci (2002) 110, 358-365. PubMed  Europe PubMed
  71. Simmer,J.P. and Hu,J.C.
    Expression, structure, and function of enamel proteinases
    Connect Tissue Res (2002) 43, 441-449. PubMed  Europe PubMed
    72. 2001
  72. Clements,J., Hooper,J., Dong,Y. and Harvey,T.
    The expanded human kallikrein (KLK) gene family: genomic organisation, tissue-specific expression and potential functions
    Biol Chem (2001) 382, 5-14. PubMed  Europe PubMed DOI  V
  73. Dong,Y., Kaushal,A., Bui,L., Chu,S., Fuller,P.J., Nicklin,J., Samaratunga,H. and Clements,J.A.
    Human kallikrein 4 (KLK4) is highly expressed in serous ovarian carcinomas
    Clin Cancer Res (2001) 7, 2363-2371. PubMed  Europe PubMed
  74. Korkmaz,K.S., Korkmaz,C.G., Pretlow,T.G. and Saatcioglu,F.
    Distinctly different gene structure of KLK4/KLK-L1/prostase/ARM1 compared with other members of the Kallikrein family: Intracellular localization, alternative cDNA forms, and regulation by multiple hormones
    DNA Cell Biol (2001) 20, 435-445. PubMed  Europe PubMed DOI  R
  75. Myers,S.A. and Clements,J.A.
    Kallikrein 4 (KLK4), a new member of the human kallikrein gene family is up-regulated by estrogen and progesterone in the human endometrial cancer cell line, KLE
    J Clin Endocrinol Metab (2001) 86, 2323-2326. PubMed  Europe PubMed DOI
  76. Obiezu,C.V., Scorilas,A., Katsaros,D., Massobrio,M., Yousef,G.M., Fracchioli,S., Rigault de la Longrais,I.A., Arisio,R. and Diamandis,E.P.
    Higher human kallikrein gene 4 (KLK4) expression indicates poor prognosis of ovarian cancer patients
    Clin Cancer Res (2001) 7, 2380-2386. PubMed  Europe PubMed
  77. [YEAR:18-12-2001]Takayama,T.K., McMullen,B.A., Nelson,P.S., Matsumura,M. and Fujikawa,K.
    Characterization of hK4 (prostase), a prostate-specific serine protease: Activation of the precursor of prostate specific antigen (pro-PSA) and single-chain urokinase-type plasminogen activator and degradation of prostatic acid phosphatase
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    78. 2000
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