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Literature for peptidase S01.251: kallikrein-related peptidase 4

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, T Target, K Knockout, P Specificity, V Review, M Mutation, R Splicing, I Inhibitor. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Afratis,N.A., Riley,B.T., Chandler,P.G., Buckle,A.M. and Sagi,I.<br>Allosteric Anti-KLK4 Antibody Development for Targeted Anti-Cancer Effects in Ovarian Carcinoma<br>J Mol Biol (2025) , 169101-169101. PubMed  Europe PubMed DOI
    2. 2023
  2. Lehto,T.K., Kovanen,R.M., Lintula,S., Malen,A., Sturenberg,C., Erickson,A., Pulkka,O.P., Stenman,U.H., Diamandis,E.P., Rannikko,A., Mirtti,T. and Koistinen,H.<br>Prognostic impact of kallikrein-related peptidase transcript levels in prostate cancer<br>Int J Cancer (2023) 153, 867-881. PubMed  Europe PubMed DOI
  3. Li,Y., Zhang,L., Cen,W. and Yuan,Y.<br>Association of KLK4 rs2235091 polymorphism with susceptibility to dental caries: a systematic review and meta-analysis<br>Front Pediatr (2023) 11, 1236000-1236000. PubMed  Europe PubMed DOI  PMC  EPMC
    4. 2021
  4. Aydin,E.B., Aydin,M., Yuzer,A., Ince,M., Ocakoglu,K. and Sezginturk,M.K.<br>Detection of Kallikrein-Related Peptidase 4 with a Label-free Electrochemical Impedance Biosensor Based on a Zinc(II) Phthalocyanine Tetracarboxylic Acid-Functionalized Disposable Indium Tin Oxide Electrode<br>ACS Biomater Sci Eng (2021) 7, 1192-1201. PubMed  Europe PubMed DOI
  5. Li,M., Srp,J., Mares,M., Wlodawer,A. and Gustchina,A.<br>Structural studies of complexes of kallikrein 4 with wild-type and mutated forms of the Kunitz-type inhibitor BbKI<br>Acta Crystallogr D Struct Biol (2021) 77, 1084-1098. PubMed  Europe PubMed DOI  PMC  EPMC
  6. Rabinovitch,E., Mihara,K., Sananes,A., Zaretsky,M., Heyne,M., Shifman,J., Aharoni,A., Hollenberg,M.D. and Papo,N.<br>A KLK4 proteinase substrate capture approach to antagonize PAR1<br>Sci Rep (2021) 11, 16170-16170. PubMed  Europe PubMed DOI  PMC  EPMC
    7. 2020
  7. Gao,J., Li,X., Gao,L., Chen,H., Baras,B.H., Liu,X., Liu,H., Rana,A., Gao,M. and Ruan,J.<br>Effects of applying amoxicillin in juvenile mice on enamel mineralization and the expression of kallikreinrelated peptidase 4 and tight junction proteins in ameloblasts<br>Int J Mol Med (2020) 46, 179-190. PubMed  Europe PubMed DOI  PMC  EPMC
  8. Tse,B.W., Kryza,T., Yeh,M.C., Dong,Y., Sokolowski,K.A., Walpole,C., Dreyer,T., Felber,J., Harris,J., Magdolen,V., Russell,P.J. and Clements,J.A.<br>KLK4 Induces Anti-Tumor Effects in Human Xenograft Mouse Models of Orthotopic and Metastatic Prostate Cancer<br>Cancers (Basel) (2020) 12 PubMed  Europe PubMed DOI
  9. Wang,J., Yao,X., Wu,D.L. and Jin,Y.<br>Kallikrein-related peptidase 4 promotes migration and invasion of endometrial stromal cells in endometriosis by inducing epithelial-mesenchymal transition<br>J Biol Regul Homeost Agents (2020) 34, 93-100. PubMed  Europe PubMed DOI
    10. 2019
  10. Li,M., Srp,J., Gustchina,A., Dauter,Z., Mares,M. and Wlodawer,A.<br>Crystal structures of the complex of a kallikrein inhibitor from Bauhinia bauhinioides with trypsin and modeling of kallikrein complexes<br>Acta Crystallogr D Struct Biol (2019) 75, 56-69. PubMed  Europe PubMed DOI  S
  11. Riley,B.T., Ilyichova,O., de Veer,S.J., Swedberg,J.E., Wilson,E., Hoke,D.E., Harris,J.M. and Buckle,A.M.<br>KLK4 Inhibition by cyclic and acyclic peptides: structural and dynamical insights into standard-mechanism protease inhibitors<br>Biochemistry (2019) 58, 2524-2533. PubMed  Europe PubMed DOI
  12. Riley,B.T., Hoke,D.E., McGowan,S. and Buckle,A.M.<br>Crystal structure of the inhibitor-free form of the serine protease kallikrein-4<br>Acta Crystallogr F Struct Biol Commun (2019) 75, 543-546. PubMed  Europe PubMed DOI  S
    13. 2018
  13. Loessner,D., Goettig,P., Preis,S., Felber,J., Bronger,H., Clements,J.A., Dorn,J. and Magdolen,V.<br>Kallikrein-related peptidases represent attractive therapeutic targets for ovarian cancer<br>Expert Opin Ther Targets (2018) 22, 745-763. PubMed  Europe PubMed DOI  T
  14. Perez,V.A., Mangum,J.E. and Hubbard,M.J.<br>Direct evidence that KLK4 is a hydroxyapatite-binding protein<br>Biochem Biophys Res Commun (2018) 495, 1896-1900. PubMed  Europe PubMed DOI
  15. Swedberg,J.E., Ghani,H.A., Harris,J.M., de Veer,S.J. and Craik,D.J.<br>Potent, selective, and cell-penetrating inhibitors of kallikrein-related peptidase 4 based on the cyclic peptide MCoTI-II<br>ACS Med Chem Lett (2018) 9, 1258-1262. PubMed  Europe PubMed DOI  PMC  EPMC
    16. 2017
  16. Reid,J.C., Matsika,A., Davies,C.M., He,Y., Broomfield,A., Bennett,N.C., Magdolen,V., Srinivasan,B., Clements,J.A. and Hooper,J.D.<br>Pericellular regulation of prostate cancer expressed kallikrein-related peptidases and matrix metalloproteinases by cell surface serine proteases<br>Am J Cancer Res (2017) 7, 2257-2274. PubMed  Europe PubMed  PMC  EPMC
  17. Smith,C.E.L., Kirkham,J., Day,P.F., Soldani,F., McDerra,E.J., Poulter,J.A., Inglehearn,C.F., Mighell,A.J. and Brookes,S.J.<br>A fourth KLK4 mutation is associated with enamel hypomineralisation and structural abnormalities<br>Front Physiol (2017) 8, 333-333. PubMed  Europe PubMed DOI  PMC  EPMC  M
    18. 2016
  18. Fuhrman-Luck,R.A., Stansfield,S.H., Stephens,C.R., Loessner,D. and Clements,J.A.<br>Prostate cancer-associated kallikrein-related peptidase 4 activates matrix metalloproteinase-1 and thrombospondin-1<br>J Proteome Res (2016) 15, 2466-2478. PubMed  Europe PubMed DOI  P
  19. Karakosta,T.D., Soosaipillai,A., Diamandis,E.P., Batruch,I. and Drabovich,A.P.<br>Quantification of human kallikrein-related peptidases in biological fluids by multiplatform targeted mass spectrometry assays<br>Mol Cell Proteomics (2016) 15, 2863-2876. PubMed  Europe PubMed DOI  A
  20. Riley,B.T., Ilyichova,O., Costa,M.G., Porebski,B.T., de Veer,S.J., Swedberg,J.E., Kass,I., Harris,J.M., Hoke,D.E. and Buckle,A.M.<br>Direct and indirect mechanisms of KLK4 inhibition revealed by structure and dynamics<br>Sci Rep (2016) 6, 35385-35385. PubMed  Europe PubMed DOI  PMC  EPMC  S
    21. 2015
  21. Lisle,J.E., Mertens-Walker,I., Stephens,C.R., Stansfield,S.H., Clements,J.A., Herington,A.C. and Stephenson,S.A.<br>Murine, but not human, ephrin-B2 can be efficiently cleaved by the serine protease kallikrein-4: implications for xenograft models of human prostate cancer<br>Exp Cell Res (2015) 333, 136-146. PubMed  Europe PubMed DOI
    22. 2014
  22. Bartlett,J.D. and Simmer,J.P.<br>Kallikrein-related peptidase-4 (KLK4): role in enamel formation and revelations from ablated mice<br>Front Physiol (2014) 5, 240-240. PubMed  Europe PubMed DOI  PMC  EPMC
  23. Kawasaki,K., Hu,J.C. and Simmer,J.P.<br>Evolution of Klk4 and enamel maturation in eutherians<br>Biol Chem (2014) 395, 1003-1013. PubMed  Europe PubMed DOI
    24. 2013
  24. Jin,Y., Qu,S., Tesikova,M., Wang,L., Kristian,A., Maelandsmo,G.M., Kong,H., Zhang,T., Jeronimo,C., Teixeira,M.R., Yuca,E., Tekedereli,I., Gorgulu,K., Alpay,N., Sood,A.K., Lopez-Berestein,G., Danielsen,H.E., Ozpolat,B. and Saatcioglu,F.<br>Molecular circuit involving KLK4 integrates androgen and mTOR signaling in prostate cancer<br>Proc Natl Acad Sci U S A (2013) 110, E2572-E2581. PubMed  Europe PubMed DOI
  25. Lundwall,A.<br>Old genes and new genes: The evolution of the kallikrein locus<br>Thromb Haemost (2013) 110, 469-475. PubMed  Europe PubMed DOI  V
  26. Wang,S.K., Hu,Y., Simmer,J.P., Seymen,F., Estrella,N.M.R.P., Pal,S., Reid,B.M., Yildirim,M., Bayram,M., Bartlett,J.D. and Hu,J.C.C.<br>Novel KLK4 and MMP20 mutations discovered by whole-exome sequencing<br>J Dent Res (2013) 92, 266-271. PubMed  Europe PubMed DOI  M
    27. 2012
  27. Simmer,J.P.<br>Kallikrein-related peptidase 4<br>[ISSN:978-0-12-407742-3] (2012) 3, 2768-2772. DOI
    28. 2011
  28. Hu,Y., Hu,J.C., Smith,C.E., Bartlett,J.D. and Simmer,J.P.<br>Kallikrein-related peptidase 4, matrix metalloproteinase 20, and the maturation of murine and porcine enamel<br>Eur J Oral Sci (2011) 119 Suppl 1, 217-225. PubMed  Europe PubMed DOI
  29. Simmer,J.P., Hu,Y., Richardson,A.S., Bartlett,J.D. and Hu,J.C.<br>Why does enamel in Klk4-null mice break above the dentino-enamel junction?<br>Cells Tissues Organs (2011) 194, 211-215. PubMed  Europe PubMed DOI  K
  30. Smith,C.E., Richardson,A.S., Hu,Y., Bartlett,J.D., Hu,J.C. and Simmer,J.P.<br>Effect of kallikrein 4 loss on enamel mineralization: comparison with mice lacking matrix metalloproteinase 20<br>J Biol Chem (2011) 286, 18149-18160. PubMed  Europe PubMed DOI
  31. Yamakoshi,Y., Yamakoshi,F., Hu,J.C. and Simmer,J.P.<br>Characterization of kallikrein-related peptidase 4 glycosylations<br>Eur J Oral Sci (2011) 119 Suppl 1, 234-240. PubMed  Europe PubMed DOI
  32. Yamakoshi,Y., Richardson,A.S., Nunez,S.M., Yamakoshi,F., Milkovich,R.N., Hu,J.C., Bartlett,J.D. and Simmer,J.P.<br>Enamel proteins and proteases in Mmp20 and Klk4 null and double-null mice<br>Eur J Oral Sci (2011) 119 Suppl 1, 206-216. PubMed  Europe PubMed DOI  K
    33. 2010
  33. Angelopoulou,K. and Karagiannis,G.S.<br>Structural characterization and expression of five novel canine kallikrein-related peptidases in mammary cancer<br>Mamm Genome (2010) 21, 516-524. PubMed  Europe PubMed DOI
  34. Gratio,V., Beaufort,N., Seiz,L., Maier,J., Virca,G.D., Debela,M., Grebenchtchikov,N., Magdolen,V. and Darmoul,D.<br>Kallikrein-related peptidase 4: a new activator of the aberrantly expressed protease-activated receptor 1 in colon cancer cells<br>Am J Pathol (2010) 176, 1452-1461. PubMed  Europe PubMed DOI
  35. Wang,W., Mize,G.J., Zhang,X. and Takayama,T.K.<br>Kallikrein-related peptidase-4 initiates tumor-stroma interactions in prostate cancer through protease-activated receptor-1<br>Int J Cancer (2010) 126, 599-610. PubMed  Europe PubMed DOI
    36. 2009
  36. Nagano,T., Kakegawa,A., Yamakoshi,Y., Tsuchiya,S., Hu,J.C., Gomi,K., Arai,T., Bartlett,J.D. and Simmer,J.P.<br>Mmp-20 and Klk4 cleavage site preferences for amelogenin sequences<br>J Dent Res (2009) 88, 823-828. PubMed  Europe PubMed DOI  PMC  EPMC  P
  37. Swedberg,J.E., Nigon,L.V., Reid,J.C., de Veer,S.J., Walpole,C.M., Stephens,C.R., Walsh,T.P., Takayama,T.K., Hooper,J.D., Clements,J.A., Buckle,A.M. and Harris,J.M.<br>Substrate-guided design of a potent and selective kallikrein-related peptidase inhibitor for kallikrein 4<br>Chem Biol (2009) 16, 633-643. PubMed  Europe PubMed DOI  I
  38. Tye,C.E., Pham,C.T., Simmer,J.P. and Bartlett,J.D.<br>DPPI may activate KLK4 during enamel formation<br>J Dent Res (2009) 88, 323-327. PubMed  Europe PubMed DOI  PMC  EPMC
    39. 2008
  39. Clements,J.A.<br>Reflections on the tissue kallikrein and kallikrein-related peptidase family - from mice to men - what have we learnt in the last two decades?<br>Biol Chem (2008) 389, 1447-1454. PubMed  Europe PubMed DOI  V
  40. Debela,M., Beaufort,N., Magdolen,V., Schechter,N.M., Craik,C.S., Schmitt,M., Bode,W. and Goettig,P.<br>Structures and specificity of the human kallikrein-related peptidases KLK 4, 5, 6, and 7<br>Biol Chem (2008) 389, 623-632. PubMed  Europe PubMed DOI  P  S
  41. Lu,Y., Papagerakis,P., Yamakoshi,Y., Hu,J.C., Bartlett,J.D. and Simmer,J.P.<br>Functions of KLK4 and MMP-20 in dental enamel formation<br>Biol Chem (2008) 389, 695-700. PubMed  Europe PubMed DOI  PMC  EPMC
  42. Mukai,S., Fukushima,T., Naka,D., Tanaka,H., Osada,Y. and Kataoka,H.<br>Activation of hepatocyte growth factor activator zymogen (pro-HGFA) by human kallikrein 1-related peptidases<br>FEBS J (2008) 275, 1003-1017. PubMed  Europe PubMed DOI
  43. Ramsay,A.J., Dong,Y., Hunt,M.L., Linn,M., Samaratunga,H., Clements,J.A. and Hooper,J.D.<br>Kallikrein-related peptidase 4 (KLK4) initiates intracellular signaling via protease-activated receptors (PARs). KLK4 and PAR-2 are co-expressed during prostate cancer progression<br>J Biol Chem (2008) 283, 12293-12304. PubMed  Europe PubMed DOI
    44. 2007
  44. Borgono,C.A., Gavigan,J.A., Alves,J., Bowles,B., Harris,J.L., Sotiropoulou,G. and Diamandis,E.P.<br>Defining the extended substrate specificity of kallikrein 1-related peptidases<br>Biol Chem (2007) 388, 1215-1225. PubMed  Europe PubMed DOI  P
  45. Fernando,S.C., Najar,F.Z., Guo,X., Zhou,L., Fu,Y., Geisert,R.D., Roe,B.A. and DeSilva,U.<br>Porcine kallikrein gene family: genomic structure, mapping, and differential expression analysis<br>Genomics (2007) 89, 429-438. PubMed  Europe PubMed DOI
  46. Klokk,T.I., Kilander,A., Xi,Z., Waehre,H., Risberg,B., Danielsen,H.E. and Saatcioglu,F.<br>Kallikrein 4 is a proliferative factor that is overexpressed in prostate cancer<br>Cancer Res (2007) 67, 5221-5230. PubMed  Europe PubMed DOI
  47. Lawrence,M.G., Veveris-Lowe,T.L., Whitbread,A.K., Nicol,D.L. and Clements,J.A.<br>Epithelial-mesenchymal transition in prostate cancer and the potential role of kallikrein serine proteases<br>Cells Tissues Organs (2007) 185, 111-115. PubMed  Europe PubMed DOI
  48. Yoon,H., Laxmikanthan,G., Lee,J., Blaber,S.I., Rodriguez,A., Kogot,J.M., Scarisbrick,I.A. and Blaber,M.<br>Activation profiles and regulatory cascades of the human kallikrein-related peptidases<br>J Biol Chem (2007) 282, 31852-31864. PubMed  Europe PubMed DOI  V
    49. 2006
  49. Beaufort,N., Debela,M., Creutzburg,S., Kellermann,J., Bode,W., Schmitt,M., Pidard,D. and Magdolen,V.<br>Interplay of human tissue kallikrein 4 (hK4) with the plasminogen activation system: hK4 regulates the structure and functions of the urokinase-type plasminogen activator receptor (uPAR)<br>Biol Chem (2006) 387, 217-222. PubMed  Europe PubMed DOI
  50. [YEAR:1-6-2006]Debela,M., Magdolen,V., Schechter,N., Valachova,M., Lottspeich,F., Craik,C.S., Choe,Y., Bode,W. and Goettig,P.<br>Specificity profiling of seven human tissue kallikreins reveals individual subsite preferences<br>J Biol Chem (1-6-2006) 281, 25678-25688. PubMed  Europe PubMed DOI  P
  51. [YEAR:3-8-2006]Debela,M., Magdolen,V., Grimminger,V., Sommerhoff,C., Messerschmidt,A., Huber,R., Friedrich,R., Bode,W. and Goettig,P.<br>Crystal structures of human tissue kallikrein 4: activity modulation by a specific zinc binding site<br>J Mol Biol (3-8-2006) 362, 1094-1107. PubMed  Europe PubMed DOI  S
  52. Obiezu,C.V., Michael,I.P., Levesque,M.A. and Diamandis,E.P.<br>Human kallikrein 4: enzymatic activity, inhibition, and degradation of extracellular matrix proteins<br>Biol Chem (2006) 387, 749-759. PubMed  Europe PubMed DOI
  53. Prezas,P., Arlt,M.J., Viktorov,P., Soosaipillai,A., Holzscheiter,L., Schmitt,M., Talieri,M., Diamandis,E.P., Kruger,A. and Magdolen,V.<br>Overexpression of the human tissue kallikrein genes KLK4, 5, 6, and 7 increases the malignant phenotype of ovarian cancer cells<br>Biol Chem (2006) 387, 807-811. PubMed  Europe PubMed DOI
  54. Wright,J.T., Daly,B., Simmons,D., Hong,S., Hart,S.P., Hart,T.C., Atsawasuwan,P. and Yamauchi,M.<br>Human enamel phenotype associated with amelogenesis imperfecta and a kallikrein-4 (g.2142G>A) proteinase mutation<br>Eur J Oral Sci (2006) 114 Suppl 1, 13-17. PubMed  Europe PubMed DOI
  55. Yamakoshi,Y., Hu,J.C., Fukae,M., Yamakoshi,F. and Simmer,J.P.<br>How do enamelysin and kallikrein 4 process the 32-kDa enamelin?<br>Eur J Oral Sci (2006) 114 Suppl 1, 45-51. PubMed  Europe PubMed DOI
    56. 2005
  56. Davidson,B., Xi,Z., Klokk,T.I., Trope,C.G., Dorum,A., Scheistroen,M. and Saatcioglu,F.<br>Kallikrein 4 expression is up-regulated in epithelial ovarian carcinoma cells in effusions<br>Am J Clin Pathol (2005) 123, 360-368. PubMed  Europe PubMed DOI
  57. [YEAR:25-5-2005]Kurlender,L., Borgono,C., Michael,I.P., Obiezu,C., Elliott,M.B., Yousef,G.M. and Diamandis,E.P.<br>A survey of alternative transcripts of human tissue kallikrein genes<br>Biochim Biophys Acta (25-5-2005) 1755, 1-14. PubMed  Europe PubMed DOI  R
  58. [YEAR:22-4-2005]Matsumura,M., Bhatt,A.S., Andress,D., Clegg,N., Takayama,T.K., Craik,C.S. and Nelson,P.S.<br>Substrates of the prostate-specific serine protease prostase/KLK4 defined by positional-scanning peptide libraries<br>Prostate (22-4-2005) 62, 1-13. PubMed  Europe PubMed DOI  P
  59. [YEAR:13-1-2005]Michael,I.P., Kurlender,L., Memari,N., Yousef,G.M., Du,D., Grass,L., Stephan,C., Jung,K. and Diamandis,E.P.<br>Intron retention: a common splicing event within the human kallikrein gene family<br>Clin Chem (13-1-2005) 51, 506-515. PubMed  Europe PubMed DOI  R
  60. [YEAR:16-6-2005]Obiezu,C.V., Shan,S.J., Soosaipillai,A., Luo,L.Y., Grass,L., Sotiropoulou,G., Petraki,C.D., Papanastasiou,P.A., Levesque,M.A. and Diamandis,E.P.<br>Human kallikrein 4: quantitative study in tissues and evidence for its secretion into biological fluids<br>Clin Chem (16-6-2005) 51, 1432-1442. PubMed  Europe PubMed DOI
  61. Veveris-Lowe,T.L., Lawrence,M.G., Collard,R.L., Bui,L., Herington,A.C., Nicol,D.L. and Clements,J.A.<br>Kallikrein 4 (hK4) and prostate-specific antigen (PSA) are associated with the loss of E-cadherin and an epithelial-mesenchymal transition (EMT)-like effect in prostate cancer cells<br>Endocr Relat Cancer (2005) 12, 631-643. PubMed  Europe PubMed DOI
    62. 2004
  62. Clements,J.A., Hooper,J.D., Odorico,D.M. and Dong,Y.<br>The tissue kallikrein gene cluster<br>[ISSN:0-12-079610-4] (2004) 2, 1569-1577.  V
  63. Hart,P.S., Hart,T.C., Michalec,M.D., Ryu,O.H., Simmons,D., Hong,S. and Wright,J.T.<br>Mutation in kallikrein 4 causes autosomal recessive hypomaturation amelogenesis imperfecta<br>J Med Genet (2004) 41, 545-549. PubMed  Europe PubMed  PMC  EPMC
  64. Simmer,J.P.<br>Prostase<br>[ISSN:0-12-079610-4] (2004) 2, 1612-1614.  V
  65. [YEAR:15-11-2004]Simmer,J.P. and Bartlett,J.D.<br>Kallikrein 4 is a secreted protein<br>Cancer Res (15-11-2004) 64, 8481-8482. PubMed  Europe PubMed DOI
  66. Xi,Z., Kaern,J., Davidson,B., Klokk,T.I., Risberg,B., Trope,C. and Saatcioglu,F.<br>Kallikrein 4 is associated with paclitaxel resistance in ovarian cancer<br>Gynecol Oncol (2004) 94, 80-85. PubMed  Europe PubMed DOI
  67. [YEAR:1-4-2004]Xi,Z., Klokk,T.I., Korkmaz,K., Kurys,P., Elbi,C., Risberg,B., Danielsen,H., Loda,M. and Saatcioglu,F.<br>Kallikrein 4 is a predominantly nuclear protein and is overexpressed in prostate cancer<br>Cancer Res (1-4-2004) 64, 2365-2370. PubMed  Europe PubMed DOI
    68. 2003
  68. Harvey,T.J., Dong,Y., Bui,L., Jarrott,R., Walsh,T. and Clements,J.A.<br>Production and characterization of antipeptide kallikrein 4 antibodies. Use of computer modeling to design peptides specific to kallikrein 4<br>Methods Mol Med (2003) 81, 241-254. PubMed  Europe PubMed DOI
    69. 2002
  69. [YEAR:1-7-2002]Hural,J.A., Friedman,R.S., McNabb,A., Steen,S.S., Henderson,R.A. and Kalos,M.<br>Identification of naturally processed CD4 T cell epitopes from the prostate-specific antigen kallikrein 4 using peptide-based in vitro stimulation<br>J Immunol (1-7-2002) 169, 557-565. PubMed  Europe PubMed
  70. Ryu,O., Hu,J.C., Yamakoshi,Y., Villemain,J.L., Cao,X., Zhang,C., Bartlett,J.D. and Simmer,J.P.<br>Porcine kallikrein-4 activation, glycosylation, activity, and expression in prokaryotic and eukaryotic hosts<br>Eur J Oral Sci (2002) 110, 358-365. PubMed  Europe PubMed
  71. Simmer,J.P. and Hu,J.C.<br>Expression, structure, and function of enamel proteinases<br>Connect Tissue Res (2002) 43, 441-449. PubMed  Europe PubMed
    72. 2001
  72. Clements,J., Hooper,J., Dong,Y. and Harvey,T.<br>The expanded human kallikrein (KLK) gene family: genomic organisation, tissue-specific expression and potential functions<br>Biol Chem (2001) 382, 5-14. PubMed  Europe PubMed DOI  V
  73. Dong,Y., Kaushal,A., Bui,L., Chu,S., Fuller,P.J., Nicklin,J., Samaratunga,H. and Clements,J.A.<br>Human kallikrein 4 (KLK4) is highly expressed in serous ovarian carcinomas<br>Clin Cancer Res (2001) 7, 2363-2371. PubMed  Europe PubMed
  74. Korkmaz,K.S., Korkmaz,C.G., Pretlow,T.G. and Saatcioglu,F.<br>Distinctly different gene structure of KLK4/KLK-L1/prostase/ARM1 compared with other members of the Kallikrein family: Intracellular localization, alternative cDNA forms, and regulation by multiple hormones<br>DNA Cell Biol (2001) 20, 435-445. PubMed  Europe PubMed DOI  R
  75. Myers,S.A. and Clements,J.A.<br>Kallikrein 4 (KLK4), a new member of the human kallikrein gene family is up-regulated by estrogen and progesterone in the human endometrial cancer cell line, KLE<br>J Clin Endocrinol Metab (2001) 86, 2323-2326. PubMed  Europe PubMed DOI
  76. Obiezu,C.V., Scorilas,A., Katsaros,D., Massobrio,M., Yousef,G.M., Fracchioli,S., Rigault de la Longrais,I.A., Arisio,R. and Diamandis,E.P.<br>Higher human kallikrein gene 4 (KLK4) expression indicates poor prognosis of ovarian cancer patients<br>Clin Cancer Res (2001) 7, 2380-2386. PubMed  Europe PubMed
  77. [YEAR:18-12-2001]Takayama,T.K., McMullen,B.A., Nelson,P.S., Matsumura,M. and Fujikawa,K.<br>Characterization of hK4 (prostase), a prostate-specific serine protease: Activation of the precursor of prostate specific antigen (pro-PSA) and single-chain urokinase-type plasminogen activator and degradation of prostatic acid phosphatase<br>Biochemistry (18-12-2001) 40, 15341-15348. PubMed  Europe PubMed DOI
    78. 2000
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