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Literature for peptidase S01.151: trypsin 1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, M Mutation, P Specificity, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2026
  1. Han,M., Cha,J. and Lee,S.H.
    Ultrasensitive Fluorescent Detection of Urinary Trypsin for Early Pancreatic Disease Diagnosis: Toward Smartphone-Assisted Analysis
    Chem Asian J (2026) 21, e70557-e70557. PubMed  Europe PubMed DOI
    2. 2025
  2. Campuzano-Gonzalez,A., Gil-Rodriguez,P., Quintana-Armas,A.X., Guerra,Y., Perez,Y. and Rudino-Pinera,E.
    Structural determination of a new non-canonical inhibition complex between porcine trypsin and M271 a potato Kunitz-STI inhibitor
    Biochem Biophys Res Commun (2025) 768, 151818-151818. PubMed  Europe PubMed DOI
  3. Chen,J., Jiang,G. and Tian,Y.
    Advances in trypsin research: sources, structural insights, applications and protein engineering for industrial use
    Int J Biol Macromol (2025) 334, 148996-148996. PubMed  Europe PubMed DOI
  4. Garge,S.Y., Suvarna,V., Sonavane,S.V. and Singh,P.K.
    A Dual-Detection AIE-Based Fluorescent Probe for Sensitive Detection of Protamine and Trypsin in Biological Media
    ACS Appl Bio Mater (2025) PubMed  Europe PubMed DOI
  5. Geisz-Fremy,A.
    Pathologically relevant trypsinogen activation in pancreatitis
    Am J Physiol Gastrointest Liver Physiol (2025) PubMed  Europe PubMed DOI
  6. Inci Ozbagci,D., Ilkar Erdagi,S. and Aydin,R.
    Plant-based phenolic acids: exploring the interaction of digestive enzyme trypsin/DNA and antioxidant potential
    J Biomol Struct Dyn (2025) , 1-20. PubMed  Europe PubMed DOI
  7. Lai,J., Wang,D., Sheng,X., Ding,C.F. and Yan,Y.
    A DNA tetrahedron-inspired magnetic hybrid with regular distribution of trypsin for ultra-fast digestion of proteins and glycoproteomics analysis
    Analyst (2025) PubMed  Europe PubMed DOI
  8. Lim,J., Seong,H. and Lee,S.H.
    A highly sensitive fluorogenic assay for trypsin in urine: a simple diagnostic approach for pancreatic diseases
    Org Biomol Chem (2025) PubMed  Europe PubMed DOI
  9. Liu,H., Yin,W., Zong,W., Wang,Y. and Lan,J.
    Nanoplastics Intensify the Inhibitory Effect of Di-n-octylo-phthalate on Trypsin: Spectroscopic and Computer Simulation Analysis
    Chem Biodivers (2025) , e00316-e00316. PubMed  Europe PubMed DOI
  10. Lv,J., Xu,J., Chen,Y., Tang,W., Xu,W., Wang,M., Zhang,X., Zhu,Z., Chen,S., Hu,Q. and Niu,L.
    Amplification by Polysaccharides for the Electrochemical Detection of Trypsin Activity
    Anal Chem (2025) 97, 20549-20556. PubMed  Europe PubMed DOI
  11. Modenbach,J.M., Moller,C., Asgarbeik,S., Geist,N., Rimkus,N., Dorr,M., Wolfgramm,H., Steil,L., Susemihl,A., Graf,L., Schmoker,O., Bottcher,D., Hammer,E., Glaubitz,J., Lammers,M., Delcea,M., Volker,U., Aghdassi,A.A., Lerch,M.M., Weiss,F.U., Bornscheuer,U.T. and Sendler,M.
    Biochemical analyses of cystatin-C dimers and cathepsin-B reveals a trypsin-driven feedback mechanism in acute pancreatitis
    Nat Commun (2025) 16, 1702-1702. PubMed  Europe PubMed DOI  PMC  EPMC
  12. Ozbagci,D.I.
    Interaction of two key biological targets -trypsin and DNA- with phenolic Phytochemicals: Insights from molecular docking and radical scavenging potential
    Arch Biochem Biophys (2025) 772, 110567-110567. PubMed  Europe PubMed DOI
  13. Xiao,W., Li,Z., Chen,C., Shi,Y., Fang,P., Xiao,S. and Fang,L.
    Revisiting the roles of trypsin in the productive infection of porcine deltacoronavirus in porcine-derived cells
    Virology (2025) 604, 110453-110453. PubMed  Europe PubMed DOI
  14. Zhang,W., Tan,M., Chen,M., Chen,W. and Li,M.J.
    Dual-functional AIE-active Ir(III) complexes for trypsin detection and organelle-targeted photodynamic therapy
    J Inorg Biochem (2025) 275, 113148-113148. PubMed  Europe PubMed DOI
  15. Zhang,W., Qi,X., Mi,Z., Wang,H., Lv,S., Song,Y., Su,P., Song,J. and Yang,Y.
    A New Phosphorylated Protein Analysis Strategy based on Trypsin Encapsulated in Metal-Organic Frameworks with High Efficiency and a Simplified Workflow
    Anal Chem (2025) PubMed  Europe PubMed DOI
    16. 2024
  16. Ahmad,M.S., Kalam,N., Akbar,Z., Shah,N., Rasheed,S. and Choudhary,M.I.
    Structural basis for the binding of famotidine, cimetidine, guanidine, and pimagedine with serine protease
    Biochem Biophys Res Commun (2024) 733, 150603-150603. PubMed  Europe PubMed DOI
  17. Al-Shabib,N.A., Khan,J.M., Malik,A., Alamri,A., Rehman,M.T., Alajmi,M.F. and Husain,F.M.
    Probing the interaction mechanisms between sunset yellow dye and trypsin protein leading to amorphous aggregation under low pH conditions
    Int J Biol Macromol (2024) 265, 130442-130442. PubMed  Europe PubMed DOI
  18. Allemann,A., Staubli,S.M. and Nebiker,C.A.
    Trypsin and Trypsinogen Activation Peptide in the Prediction of Severity of Acute Pancreatitis
    Life (Basel) (2024) 14 PubMed  Europe PubMed DOI  PMC  EPMC  V
  19. Behshad,Y., Pazhang,M., Najavand,S. and Sabzi,M.
    Enhancing Enzyme Stability and Functionality: Covalent Immobilization of Trypsin on Magnetic Gum Arabic Modified Fe(3)O(4) Nanoparticles
    Appl Biochem Biotechnol (2024) 196, 5283-5300. PubMed  Europe PubMed DOI
  20. Cai,H., Yuan,R., Huang,S., Huang,Y., Lin,C., Lin,Y., Luo,F., Lin,Z. and Wang,L.
    Sensitive trypsin sensor based on the regulation of microscale ionic current rectification by the selectivity hydrolysis of hydrogel filled in microchannel
    Talanta (2024) 285, 127422-127422. PubMed  Europe PubMed DOI
  21. Crosby,H.A., Keim,K., Kwiecinski,J.M., Langouet-Astrie,C.J., Oshima,K., LaRiviere,W.B., Schmidt,E.P. and Horswill,A.R.
    Host-derived protease promotes aggregation of Staphylococcus aureus by cleaving the surface protein SasG
    MBio (2024) 15, e0348323-e0348323. PubMed  Europe PubMed DOI  PMC  EPMC
  22. Ofori,S., Desai,H.S., Shikwana,F., Boatner,L.M., Dominguez Iii,E.R., Castellon,J.O. and Backus,K.M.
    Generating cysteine-trypsin cleavage sites with 2-chloroacetamidine capping
    Chem Commun (Camb) (2024) 60, 8856-8859. PubMed  Europe PubMed DOI
  23. Patel,C.K. and Mukherjee,T.K.
    Biomolecular Condensation of Trypsin Prevents Autolysis and Promotes Ca(2+)-Mediated Activation of Esterase Activity
    Biomacromolecules (2024) 25, 6082-6092. PubMed  Europe PubMed DOI
  24. Song,H., Choi,H., Kim,Y.S. and Lee,S.H.
    Micelle-based fluorogenic sensing of trypsin: a sensitive method in pancreatic disease diagnosis
    Org Biomol Chem (2024) 22, 4243-4248. PubMed  Europe PubMed DOI
  25. Wang,J., Kong,J. and Zhang,X.
    Riboflavin-induced photo-ATRP electrochemical strategy for detection of biomarker trypsin
    Talanta (2024) 277, 126386-126386. PubMed  Europe PubMed DOI
  26. Xiang,Y., Jiang,Y. and Lu,L.
    Low-Dose Trypsin Accelerates Wound Healing via Protease-Activated Receptor 2
    ACS Pharmacol Transl Sci (2024) 7, 274-284. PubMed  Europe PubMed DOI  PMC  EPMC
  27. Zierke,L., John,D., Gischke,M., Tran,Q.T., Sendler,M., Weiss,F.U., Bornscheuer,U.T., Ritter,C., Lerch,M.M. and Aghdassi,A.A.
    Initiation of acute pancreatitis in mice is independent of fusion between lysosomes and zymogen granules
    Cell Mol Life Sci (2024) 81, 207-207. PubMed  Europe PubMed DOI  PMC  EPMC
    28. 2023
  28. Arora,A., Sharma,K. and Tripathi,S.K.
    Impact of luminescent MoSe(2) quantum dots on activity of trypsin under different pH environment
    Spectrochim Acta A Mol Biomol Spectrosc (2023) 302, 122958-122958. PubMed  Europe PubMed DOI
  29. Bianchimano,P., Iwanowski,K., Smith,E.M., Cantor,A., Leone,P., Bongers,G., Gonzalez,C.G., Hongsup,Y., Elias,J., Weiner,H.L., Clemente,J.C. and Tankou,S.K.
    Oral vancomycin treatment suppresses gut trypsin activity and preserves intestinal barrier function during EAE
    iScience (2023) 26, 108143-108143. PubMed  Europe PubMed DOI  PMC  EPMC
  30. Chen,J., Xu,F. and Wang,Y.
    Biomass-derived magnetic nanocomposites modified by choline chloride/citric acid based natural deep eutectic solvents for the magnetic solid phase extraction of trypsin
    Analyst (2023) 148, 2316-2326. PubMed  Europe PubMed DOI
  31. Kellnerova,S., Huber,S., Massri,M., Fleischer,V., Losso,K., Sarg,B., Kremser,L., Talasz,H., He,X., Varrone,E., Brigotti,M., Ardissino,G., Orth-Holler,D. and Wurzner,R.
    Enzymatic Cleavage of Stx2a in the Gut and Identification of Pancreatic Elastase and Trypsin as Possible Main Cleavers
    Microorganisms (2023) 11 PubMed  Europe PubMed DOI  PMC  EPMC
  32. Liu,X., Huang,Q., Pan,P., Fang,M., Zhang,Y., Yang,S., Li,M. and Liu,Y.
    Comparative Study of the Preparation of High-Molecular-Weight Fibroin by Degumming Silk with Several Neutral Proteases
    Polymers (Basel) (2023) 15 PubMed  Europe PubMed DOI  PMC  EPMC
  33. Saroha,B., Kumar,G., Arya,P., Raghav,N. and Kumar,S.
    Some morpholine tethered novel aurones: Design, synthesis, biological, kinetic and molecular docking studies
    Bioorg Chem (2023) 140, 106805-106805. PubMed  Europe PubMed DOI
  34. Solovyev,M., Kashinskaya,E. and Gisbert,E.
    A meta-analysis for assessing the contributions of trypsin and chymotrypsin as the two major endoproteases in protein hydrolysis in fish intestine
    Comp Biochem Physiol A Mol Integr Physiol (2023) 278, 111372-111372. PubMed  Europe PubMed DOI
  35. Sun,Z., Xiao,W., Li,N., Chang,L., Xu,P. and Li,Y.
    Large-Scale Profiling of Unexpected Tryptic Cleaved Sites at Ubiquitinated Lysines
    J Proteome Res (2023) 22, 1245-1254. PubMed  Europe PubMed DOI
  36. Vosahlova-Kadlecova,Z., Gilar,M., Molnarova,K., Kozlik,P. and Kalikova,K.
    Mixed-mode column allows simple direct coupling with immobilized enzymatic reactor for on-line protein digestion
    J Chromatogr B Analyt Technol Biomed Life Sci (2023) 1228, 123866-123866. PubMed  Europe PubMed DOI
  37. Woessmann,J., Petrosius,V., Uresin,N., Kotol,D., Aragon-Fernandez,P., Hober,A., auf dem Keller,U., Edfors,F. and Schoof,E.M.
    Assessing the Role of Trypsin in Quantitative Plasma and Single-Cell Proteomics toward Clinical Application
    Anal Chem (2023) 95, 13649-13658. PubMed  Europe PubMed DOI  PMC  EPMC
  38. Wu,N.N., Chen,L.G., Xiao,M.Z., Yuan,R.Y. and Wang,H.B.
    Determination of trypsin using protamine mediated fluorescent enhancement of DNA templated Au nanoclusters
    Mikrochim Acta (2023) 190, 158-158. PubMed  Europe PubMed DOI
    39. 2022
  39. Ai,Y., Xu,J., Gunawardena,H.P., Zare,R.N. and Chen,H.
    Investigation of Tryptic Protein Digestion in Microdroplets and in Bulk Solution
    J Am Soc Mass Spectrom (2022) 33, 1238-1249. PubMed  Europe PubMed DOI
  40. Ansari,N., Rizzi,V. and Parrinello,M.
    Water regulates the residence time of Benzamidine in Trypsin
    Nat Commun (2022) 13, 5438-5438. PubMed  Europe PubMed DOI  PMC  EPMC  I
  41. Arnaiz,A., Guembe-Garcia,M., Delgado-Pinar,E., Valente,A.J.M., Ibeas,S., Garcia,J.M. and Vallejos,S.
    The role of polymeric chains as a protective environment for improving the stability and efficiency of fluorogenic peptide substrates
    Sci Rep (2022) 12, 8818-8818. PubMed  Europe PubMed DOI  PMC  EPMC
  42. Li,H., Gao,Z. and Zhang,S.
    Localization of trypsin, chymotrypsin and elastase in the digestive tract of amphioxus Branchiostoma japonicum with implications to the origin of vertebrate pancreas
    Tissue Cell (2022) 79, 101943-101943. PubMed  Europe PubMed DOI
  43. Li,Y., Watanabe,E., Kawashima,Y., Plichta,D.R., Wang,Z., Ujike,M., Ang,Q.Y., Wu,R., Furuichi,M., Takeshita,K., Yoshida,K., Nishiyama,K., Kearney,S.M., Suda,W., Hattori,M., Sasajima,S., Matsunaga,T., Zhang,X., Watanabe,K., Fujishiro,J., Norman,J.M., Olle,B., Matsuyama,S., Namkoong,H., Uwamino,Y., Ishii,M., Fukunaga,K., Hasegawa,N., Ohara,O., Xavier,R.J., Atarashi,K. and Honda,K.
    Identification of trypsin-degrading commensals in the large intestine
    Nature (2022) 609, 582-589. PubMed  Europe PubMed DOI  PMC  EPMC
  44. Park,S., Lee,H. and Yang,H.
    Sensitive Affinity-Based Biosensor Using the Autocatalytic Activation of Trypsinogen Mutant by Trypsin with Low Self-activation
    ACS Appl Bio Mater (2022) PubMed  Europe PubMed DOI
    45. 2021
  45. Fu,Z., Akula,S., Thorpe,M. and Hellman,L.
    Marked difference in efficiency of the digestive enzymes pepsin, trypsin, chymotrypsin, and pancreatic elastase to cleave tightly folded proteins
    Biol Chem (2021) 402, 861-867. PubMed  Europe PubMed DOI
  46. Mahmoud,G.S., Hosny,G. and Sayed,S.A.
    Hepatoprotective effect of trypsin/chymotrypsin against olanzapine-induced non-alcoholic steatohepatitis in rats
    Can J Physiol Pharmacol (2021) , 1-9. PubMed  Europe PubMed DOI
  47. More,K.N., Lim,T.H., Kang,J. and Chang,D.J.
    A Fluorogenic Assay: Analysis of Chemical Modification of Lysine and Arginine to Control Proteolytic Activity of Trypsin
    Molecules (2021) 26 PubMed  Europe PubMed DOI  PMC  EPMC
  48. Pandeswari,P.B., Chary,R.N., Kamalanathan,A.S., Prabhakar,S. and Sabareesh,V.
    Mimicking LysC Proteolysis by 'Arginine-Modification-cum-Trypsin digestion': Comparison of Bottom-Up & Middle-Down Proteomic Approaches by ESI-QTOF-MS
    Protein Pept Lett (2021) PubMed  Europe PubMed DOI
  49. Rivera Del Rio,A., Keppler,J.K., Boom,R.M. and Janssen,A.E.M.
    Protein acidification and hydrolysis by pepsin ensure efficient trypsin-catalyzed hydrolysis
    Food Funct (2021) 12, 4570-4581. PubMed  Europe PubMed DOI
  50. Taraskin,A.S., Semenov,K.K., Protasov,A.V., Lozhkov,A.A., Tyulin,A.A., Shaldzhyan,A.A., Ramsay,E.S., Mirgorodskaya,O.A., Klotchenko,S.A. and Zabrodskaya,Y.A.
    Quench me if you can: Alpha-2-macroglobulin trypsin complexes enable serum biomarker analysis by MALDI mass spectrometry
    Biochimie (2021) 185, 87-95. PubMed  Europe PubMed DOI
  51. Yuan,N., Jia,L. and Zhu,J.
    Label-free Fluorescence Turn on Trypsin Assay Based on Gemini Surfactant/heparin/Nile Red Supramolecular Assembly
    J Fluoresc (2021) 31, 1537-1545. PubMed  Europe PubMed DOI
    52. 2020
  52. Ahmed Al-Hadhrami,N., Ladwig,A., Rahman,A., Rozas,I., Paul,G.M. and Evans,P.
    Synthesis of 2-guanidinyl pyridines and their trypsin inhibition and docking
    Bioorg Med Chem (2020) 28, 115612-115612. PubMed  Europe PubMed DOI
  53. Bubis,J.A., Gorshkov,V., Gorshkov,M.V. and Kjeldsen,F.
    PhosphoShield: Improving Trypsin Digestion of Phosphoproteins by Shielding the Negatively Charged Phosphate Moiety
    J Am Soc Mass Spectrom (2020) PubMed  Europe PubMed DOI
  54. Chen,X., Chen,D., Huang,L., Chen,X., Zhou,M., Xi,X., Ma,C., Chen,T. and Wang,L.
    Identification and Target-Modification of SL-BBI: A Novel Bowman-Birk Type Trypsin Inhibitor from Sylvirana latouchii
    Biomolecules (2020) 10 PubMed  Europe PubMed DOI
  55. Dau,T., Bartolomucci,G. and Rappsilber,J.
    Proteomics Using Protease Alternatives to Trypsin Benefits from Sequential Digestion with Trypsin
    Anal Chem (2020) 92, 9523-9527. PubMed  Europe PubMed DOI  PMC  EPMC
  56. Duan,X., Li,N., Wang,G. and Su,X.
    High sensitive ratiometric fluorescence analysis of trypsin and dithiothreitol based on WS2 QDs
    Talanta (2020) 219, 121171-121171. PubMed  Europe PubMed DOI
  57. Estaras,M., Ameur,F.Z., Estevez,M., Diaz-Velasco,S. and Gonzalez,A.
    The lysine derivative aminoadipic acid, a biomarker of protein oxidation and diabetes-risk, induces production of reactive oxygen species and impairs trypsin secretion in mouse pancreatic acinar cells
    Food Chem Toxicol (2020) , 111594-111594. PubMed  Europe PubMed DOI
  58. Hu,Q., Bao,Y., Gan,S., Zhang,Y., Han,D. and Niu,L.
    Electrochemically controlled grafting of polymers for ultrasensitive electrochemical assay of trypsin activity
    Biosens Bioelectron (2020) 165, 112358-112358. PubMed  Europe PubMed DOI
  59. Jaimes,J., Millet,J. and Whittaker,G.
    Proteolytic Cleavage of the SARS-CoV-2 Spike Protein and the Role of the Novel S1/S2 Site
    SSRN (2020) , 3581359-3581359. PubMed  Europe PubMed DOI  PMC  EPMC
  60. Kahler,U., Kamenik,A.S., Waibl,F., Kraml,J. and Liedl,K.R.
    Protein-Protein Binding as a Two-Step Mechanism: Preselection of Encounter Poses during the Binding of BPTI and Trypsin
    Biophys J (2020) 119, 652-666. PubMed  Europe PubMed DOI  PMC  EPMC
  61. Ma,H., Zou,T., Li,H. and Cheng,H.
    The interaction of sodium dodecyl sulfate with trypsin: Multi-spectroscopic analysis, molecular docking, and molecular dynamics simulation
    Int J Biol Macromol (2020) PubMed  Europe PubMed DOI
  62. Melikishvili,S., Dizon,M. and Hianik,T.
    Application of high-resolution ultrasonic spectroscopy for real-time monitoring of trypsin activity in beta-casein solution
    Food Chem (2020) 337, 127759-127759. PubMed  Europe PubMed DOI
  63. Millan-Martin,S., Jakes,C., Carillo,S., Buchanan,T., Guender,M., Kristensen,D.B., Sloth,T.M., Orgaard,M., Cook,K. and Bones,J.
    Inter-laboratory study of an optimised peptide mapping workflow using automated trypsin digestion for monitoring monoclonal antibody product quality attributes
    Anal Bioanal Chem (2020) PubMed  Europe PubMed DOI
  64. Mourao,C.B.F., Brand,G.D., Fernandes,J.P.C., Prates,M.V., Bloch,C., Jr., Barbosa,J.A.R.G., Freitas,S.M., Restano-Cassulini,R., Possani,L.D. and Schwartz,E.F.
    Head-to-Tail Cyclization after Interaction with Trypsin: A Scorpion Venom Peptide that Resembles Plant Cyclotides
    J Med Chem (2020) PubMed  Europe PubMed DOI
  65. Nanjundaiah,S.N., Ma,J., Sukumaran,S. and Sambasivam,G.
    Development of clone with novel TrpE fusion tag in E. coli for overexpression of trypsin in a bench-scale bioreactor
    Prep Biochem Biotechnol (2020) , 1-9. PubMed  Europe PubMed DOI
  66. Niu,B., Martinelli Ii,M., Jiao,Y., Wang,C., Cao,M., Wang,J. and Meinke,E.
    Nonspecific cleavages arising from reconstitution of trypsin under mildly acidic conditions
    PLoS ONE (2020) 15, e0236740-e0236740. PubMed  Europe PubMed DOI  PMC  EPMC
  67. Retzl,B., Hellinger,R., Muratspahic,E., Pinto,M.E.F., Bolzani,V.S. and Gruber,C.W.
    Discovery of a Beetroot Protease Inhibitor to Identify and Classify Plant-Derived Cystine Knot Peptides
    J Nat Prod (2020) PubMed  Europe PubMed DOI
  68. Smith,D., Cwiklinski,K., Jewhurst,H., Tikhonova,I.G. and Dalton,J.P.
    An atypical and functionally diverse family of Kunitz-type cysteine/serine proteinase inhibitors secreted by the helminth parasite Fasciola hepatica
    Sci Rep (2020) 10, 20657-20657. PubMed  Europe PubMed DOI  PMC  EPMC
  69. Totsch,N. and Hoffmann,D.
    Bayesian Data Integration Questions Classic Study on Protease Self-Digest Kinetics
    ACS Omega (2020) 5, 15162-15168. PubMed  Europe PubMed DOI  PMC  EPMC
    70. 2018
  70. Gallegos,D.A., Sauri,J., Cohen,R.D., Wan,X., Videau,P., Vallota-Eastman,A.O., Shaala,L.A., Youssef,D.T.A., Williamson,R.T., Martin,G.E., Philmus,B., Sikora,A.E., Ishmael,J.E. and McPhail,K.L.
    Jizanpeptins, cyanobacterial protease inhibitors from a Symploca sp. cyanobacterium collected in the Red Sea
    J Nat Prod (2018) 81, 1417-1425. PubMed  Europe PubMed DOI  I
  71. Liu,L., Yu,H., Du,K., Wang,Z., Gan,Y. and Huang,H.
    Enhanced trypsin thermostability in Pichia pastoris through truncating the flexible region
    Microb Cell Fact (2018) 17, 165-165. PubMed  Europe PubMed DOI  PMC  EPMC
  72. Perutka,Z. and Sebela,M.
    Pseudotrypsin: a little-known trypsin proteoform
    Molecules (2018) 23 PubMed  Europe PubMed DOI
  73. Sato,D., Kondo,T. and Kato,T.
    Dual emissive bispyrene peptide probes for highly sensitive measurements of trypsin activity and evaluation of trypsin inhibitors
    Bioorg Med Chem (2018) 26, 3468-3473. PubMed  Europe PubMed DOI  A
  74. Schiebel,J., Gaspari,R., Wulsdorf,T., Ngo,K., Sohn,C., Schrader,T.E., Cavalli,A., Ostermann,A., Heine,A. and Klebe,G.
    Intriguing role of water in protein-ligand binding studied by neutron crystallography on trypsin complexes
    Nat Commun (2018) 9, 3559-3559. PubMed  Europe PubMed DOI  PMC  EPMC  S
  75. Wang,M., Su,D., Wang,G. and Su,X.
    A fluorometric sensing method for sensitive detection of trypsin and its inhibitor based on gold nanoclusters and gold nanoparticles
    Anal Bioanal Chem (2018) 410, 6891-6900. PubMed  Europe PubMed DOI  A
  76. Wang,Y., Zhou,L., Kang,Q. and Yu,L.
    Simple and label-free liquid crystal-based sensor for detecting trypsin coupled to the interaction between cationic surfactant and BSA
    Talanta (2018) 183, 223-227. PubMed  Europe PubMed DOI  A
    77. 2017
  77. Aithal,M., PavanKumar,N.N., Buddha,M., UmamaheshwaraRao,K. and Hazra,P.
    Kinetic and structural differentiation of trypsin from different origins
    BioPharm Int (2017) 30, 38-43, 56.
  78. Liu,B., Xiao,H., Li,J., Geng,S., Ma,H. and Liang,G.
    Interaction of phenolic acids with trypsin: experimental and molecular modeling studies
    Food Chem (2017) 228, 1-6. PubMed  Europe PubMed DOI  I
  79. Momeni,L., Mahmodian,S., Shareghi,B., Saboury,A.A. and Farhadian,S.
    The functional and structural stabilization of trypsin by sucrose
    Int J Biol Macromol (2017) 99, 343-349. PubMed  Europe PubMed DOI
  80. Wu,M., Wang,X., Wang,K. and Guo,Z.
    An ultrasensitive fluorescent nanosensor for trypsin based on upconversion nanoparticles
    Talanta (2017) 174, 797-802. PubMed  Europe PubMed DOI  A
  81. Xia,T., Ma,Q., Hu,T. and Su,X.
    A novel magnetic/photoluminescence bifunctional nanohybrid for the determination of trypsin
    Talanta (2017) 170, 286-290. PubMed  Europe PubMed DOI  A
  82. Zhao,D., Chen,C., Zhao,J., Sun,J. and Yang,X.
    Label-free fluorescence turn-on strategy for trypsin activity based on thiolate-protected gold nanoclusters with bovine serum albumin as the substrate
    Sens Actuators, B Chem (2017) 247, 392-399. DOI  A
    83. 2016
  83. Andre,J., Saleh,D., Syldatk,C. and Hausmann,R.
    Effect of spacer modification on enzymatic synthetic and hydrolytic activities of immobilized trypsin
    J Mol Catal B Enzym (2016) 125, 88-96. DOI
  84. Cleary,J.A. and Malthouse,J.P.G.
    A new lysine derived glyoxal inhibitor of trypsin, its properties and utilization for studying the stabilization of tetrahedral adducts by trypsin
    Biochem Biophys Rep (2016) 5, 272-284. PubMed  Europe PubMed DOI  I
  85. Erturk,G., Hedstrom,M. and Mattiasson,B.
    A sensitive and real-time assay of trypsin by using molecular imprinting-based capacitive biosensor
    Biosens Bioelectron (2016) 86, 557-565. PubMed  Europe PubMed DOI  A
  86. Pazhang,M., Mehrnejad,F., Pazhang,Y., Falahati,H. and Chaparzadeh,N.
    Effect of sorbitol and glycerol on the stability of trypsin and difference between their stabilization effects in the various solvents
    Biotechnol Appl Biochem (2016) 63, 206-213. PubMed  Europe PubMed DOI
  87. Raskovic,B., Vatic,S., Andelkovic,B., Blagojevic,V. and Polovic,N.
    Optimizing storage conditions to prevent cold denaturation of trypsin for sequencing and to prolong its shelf life
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