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Literature for peptidase S01.151: trypsin 1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, M Mutation, P Specificity, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Campuzano-Gonzalez,A., Gil-Rodriguez,P., Quintana-Armas,A.X., Guerra,Y., Perez,Y. and Rudino-Pinera,E.
    Structural determination of a new non-canonical inhibition complex between porcine trypsin and M271 a potato Kunitz-STI inhibitor
    Biochem Biophys Res Commun768, 151818-151818. PubMed  Europe PubMed DOI
  2. Lai,J., Wang,D., Sheng,X., Ding,C.F. and Yan,Y.
    A DNA tetrahedron-inspired magnetic hybrid with regular distribution of trypsin for ultra-fast digestion of proteins and glycoproteomics analysis
    Analyst PubMed  Europe PubMed DOI
  3. Modenbach,J.M., Moller,C., Asgarbeik,S., Geist,N., Rimkus,N., Dorr,M., Wolfgramm,H., Steil,L., Susemihl,A., Graf,L., Schmoker,O., Bottcher,D., Hammer,E., Glaubitz,J., Lammers,M., Delcea,M., Volker,U., Aghdassi,A.A., Lerch,M.M., Weiss,F.U., Bornscheuer,U.T. and Sendler,M.
    Biochemical analyses of cystatin-C dimers and cathepsin-B reveals a trypsin-driven feedback mechanism in acute pancreatitis
    Nat Commun16, 1702-1702. PubMed  Europe PubMed DOI
    4. 2024
  4. Ahmad,M.S., Kalam,N., Akbar,Z., Shah,N., Rasheed,S. and Choudhary,M.I.
    Structural basis for the binding of famotidine, cimetidine, guanidine, and pimagedine with serine protease
    Biochem Biophys Res Commun733, 150603-150603. PubMed  Europe PubMed DOI
  5. Al-Shabib,N.A., Khan,J.M., Malik,A., Alamri,A., Rehman,M.T., Alajmi,M.F. and Husain,F.M.
    Probing the interaction mechanisms between sunset yellow dye and trypsin protein leading to amorphous aggregation under low pH conditions
    Int J Biol Macromol265, 130442-130442. PubMed  Europe PubMed DOI
  6. Allemann,A., Staubli,S.M. and Nebiker,C.A.
    Trypsin and Trypsinogen Activation Peptide in the Prediction of Severity of Acute Pancreatitis
    Life (Basel)14, PubMed  Europe PubMed DOI  V
  7. Behshad,Y., Pazhang,M., Najavand,S. and Sabzi,M.
    Enhancing Enzyme Stability and Functionality: Covalent Immobilization of Trypsin on Magnetic Gum Arabic Modified Fe(3)O(4) Nanoparticles
    Appl Biochem Biotechnol196, 5283-5300. PubMed  Europe PubMed DOI
  8. Cai,H., Yuan,R., Huang,S., Huang,Y., Lin,C., Lin,Y., Luo,F., Lin,Z. and Wang,L.
    Sensitive trypsin sensor based on the regulation of microscale ionic current rectification by the selectivity hydrolysis of hydrogel filled in microchannel
    Talanta285, 127422-127422. PubMed  Europe PubMed DOI
  9. Crosby,H.A., Keim,K., Kwiecinski,J.M., Langouet-Astrie,C.J., Oshima,K., LaRiviere,W.B., Schmidt,E.P. and Horswill,A.R.
    Host-derived protease promotes aggregation of Staphylococcus aureus by cleaving the surface protein SasG
    MBio15, e0348323-e0348323. PubMed  Europe PubMed DOI
  10. Ofori,S., Desai,H.S., Shikwana,F., Boatner,L.M., Dominguez Iii,E.R., Castellon,J.O. and Backus,K.M.
    Generating cysteine-trypsin cleavage sites with 2-chloroacetamidine capping
    Chem Commun (Camb)60, 8856-8859. PubMed  Europe PubMed DOI
  11. Patel,C.K. and Mukherjee,T.K.
    Biomolecular Condensation of Trypsin Prevents Autolysis and Promotes Ca(2+)-Mediated Activation of Esterase Activity
    Biomacromolecules25, 6082-6092. PubMed  Europe PubMed DOI
  12. Song,H., Choi,H., Kim,Y.S. and Lee,S.H.
    Micelle-based fluorogenic sensing of trypsin: a sensitive method in pancreatic disease diagnosis
    Org Biomol Chem22, 4243-4248. PubMed  Europe PubMed DOI
  13. Wang,J., Kong,J. and Zhang,X.
    Riboflavin-induced photo-ATRP electrochemical strategy for detection of biomarker trypsin
    Talanta277, 126386-126386. PubMed  Europe PubMed DOI
  14. Xiang,Y., Jiang,Y. and Lu,L.
    Low-Dose Trypsin Accelerates Wound Healing via Protease-Activated Receptor 2
    ACS Pharmacol Transl Sci7, 274-284. PubMed  Europe PubMed DOI
    15. 2023
  15. Arora,A., Sharma,K. and Tripathi,S.K.
    Impact of luminescent MoSe(2) quantum dots on activity of trypsin under different pH environment
    Spectrochim Acta A Mol Biomol Spectrosc302, 122958-122958. PubMed  Europe PubMed DOI
  16. Bianchimano,P., Iwanowski,K., Smith,E.M., Cantor,A., Leone,P., Bongers,G., Gonzalez,C.G., Hongsup,Y., Elias,J., Weiner,H.L., Clemente,J.C. and Tankou,S.K.
    Oral vancomycin treatment suppresses gut trypsin activity and preserves intestinal barrier function during EAE
    iScience26, 108143-108143. PubMed  Europe PubMed DOI
  17. Chen,J., Xu,F. and Wang,Y.
    Biomass-derived magnetic nanocomposites modified by choline chloride/citric acid based natural deep eutectic solvents for the magnetic solid phase extraction of trypsin
    Analyst148, 2316-2326. PubMed  Europe PubMed DOI
  18. Kellnerova,S., Huber,S., Massri,M., Fleischer,V., Losso,K., Sarg,B., Kremser,L., Talasz,H., He,X., Varrone,E., Brigotti,M., Ardissino,G., Orth-Holler,D. and Wurzner,R.
    Enzymatic Cleavage of Stx2a in the Gut and Identification of Pancreatic Elastase and Trypsin as Possible Main Cleavers
    Microorganisms11, PubMed  Europe PubMed DOI
  19. Liu,X., Huang,Q., Pan,P., Fang,M., Zhang,Y., Yang,S., Li,M. and Liu,Y.
    Comparative Study of the Preparation of High-Molecular-Weight Fibroin by Degumming Silk with Several Neutral Proteases
    Polymers (Basel)15, PubMed  Europe PubMed DOI
  20. Solovyev,M., Kashinskaya,E. and Gisbert,E.
    A meta-analysis for assessing the contributions of trypsin and chymotrypsin as the two major endoproteases in protein hydrolysis in fish intestine
    Comp Biochem Physiol A Mol Integr Physiol278, 111372-111372. PubMed  Europe PubMed DOI
  21. Sun,Z., Xiao,W., Li,N., Chang,L., Xu,P. and Li,Y.
    Large-Scale Profiling of Unexpected Tryptic Cleaved Sites at Ubiquitinated Lysines
    J Proteome Res22, 1245-1254. PubMed  Europe PubMed DOI
  22. Vosahlova-Kadlecova,Z., Gilar,M., Molnarova,K., Kozlik,P. and Kalikova,K.
    Mixed-mode column allows simple direct coupling with immobilized enzymatic reactor for on-line protein digestion
    J Chromatogr B Analyt Technol Biomed Life Sci1228, 123866-123866. PubMed  Europe PubMed DOI
  23. Woessmann,J., Petrosius,V., Uresin,N., Kotol,D., Aragon-Fernandez,P., Hober,A., auf dem Keller,U., Edfors,F. and Schoof,E.M.
    Assessing the Role of Trypsin in Quantitative Plasma and Single-Cell Proteomics toward Clinical Application
    Anal Chem95, 13649-13658. PubMed  Europe PubMed DOI
  24. Wu,N.N., Chen,L.G., Xiao,M.Z., Yuan,R.Y. and Wang,H.B.
    Determination of trypsin using protamine mediated fluorescent enhancement of DNA templated Au nanoclusters
    Mikrochim Acta190, 158-158. PubMed  Europe PubMed DOI
    25. 2022
  25. Ai,Y., Xu,J., Gunawardena,H.P., Zare,R.N. and Chen,H.
    Investigation of Tryptic Protein Digestion in Microdroplets and in Bulk Solution
    J Am Soc Mass Spectrom33, 1238-1249. PubMed  Europe PubMed DOI
  26. Ansari,N., Rizzi,V. and Parrinello,M.
    Water regulates the residence time of Benzamidine in Trypsin
    Nat Commun13, 5438-5438. PubMed  Europe PubMed DOI  I
  27. Arnaiz,A., Guembe-Garcia,M., Delgado-Pinar,E., Valente,A.J.M., Ibeas,S., Garcia,J.M. and Vallejos,S.
    The role of polymeric chains as a protective environment for improving the stability and efficiency of fluorogenic peptide substrates
    Sci Rep12, 8818-8818. PubMed  Europe PubMed DOI
  28. Li,H., Gao,Z. and Zhang,S.
    Localization of trypsin, chymotrypsin and elastase in the digestive tract of amphioxus Branchiostoma japonicum with implications to the origin of vertebrate pancreas
    Tissue Cell79, 101943-101943. PubMed  Europe PubMed DOI
  29. Li,Y., Watanabe,E., Kawashima,Y., Plichta,D.R., Wang,Z., Ujike,M., Ang,Q.Y., Wu,R., Furuichi,M., Takeshita,K., Yoshida,K., Nishiyama,K., Kearney,S.M., Suda,W., Hattori,M., Sasajima,S., Matsunaga,T., Zhang,X., Watanabe,K., Fujishiro,J., Norman,J.M., Olle,B., Matsuyama,S., Namkoong,H., Uwamino,Y., Ishii,M., Fukunaga,K., Hasegawa,N., Ohara,O., Xavier,R.J., Atarashi,K. and Honda,K.
    Identification of trypsin-degrading commensals in the large intestine
    Nature609, 582-589. PubMed  Europe PubMed DOI
  30. Park,S., Lee,H. and Yang,H.
    Sensitive Affinity-Based Biosensor Using the Autocatalytic Activation of Trypsinogen Mutant by Trypsin with Low Self-activation
    ACS Appl Bio Mater PubMed  Europe PubMed DOI
    31. 2021
  31. Fu,Z., Akula,S., Thorpe,M. and Hellman,L.
    Marked difference in efficiency of the digestive enzymes pepsin, trypsin, chymotrypsin, and pancreatic elastase to cleave tightly folded proteins
    Biol Chem402, 861-867. PubMed  Europe PubMed DOI
  32. Mahmoud,G.S., Hosny,G. and Sayed,S.A.
    Hepatoprotective effect of trypsin/chymotrypsin against olanzapine-induced non-alcoholic steatohepatitis in rats
    Can J Physiol Pharmacol1-9. PubMed  Europe PubMed DOI
  33. More,K.N., Lim,T.H., Kang,J. and Chang,D.J.
    A Fluorogenic Assay: Analysis of Chemical Modification of Lysine and Arginine to Control Proteolytic Activity of Trypsin
    Molecules26, PubMed  Europe PubMed DOI
  34. Pandeswari,P.B., Chary,R.N., Kamalanathan,A.S., Prabhakar,S. and Sabareesh,V.
    Mimicking LysC Proteolysis by 'Arginine-Modification-cum-Trypsin digestion': Comparison of Bottom-Up & Middle-Down Proteomic Approaches by ESI-QTOF-MS
    Protein Pept Lett PubMed  Europe PubMed DOI
  35. Rivera Del Rio,A., Keppler,J.K., Boom,R.M. and Janssen,A.E.M.
    Protein acidification and hydrolysis by pepsin ensure efficient trypsin-catalyzed hydrolysis
    Food Funct12, 4570-4581. PubMed  Europe PubMed DOI
  36. Taraskin,A.S., Semenov,K.K., Protasov,A.V., Lozhkov,A.A., Tyulin,A.A., Shaldzhyan,A.A., Ramsay,E.S., Mirgorodskaya,O.A., Klotchenko,S.A. and Zabrodskaya,Y.A.
    Quench me if you can: Alpha-2-macroglobulin trypsin complexes enable serum biomarker analysis by MALDI mass spectrometry
    Biochimie185, 87-95. PubMed  Europe PubMed DOI
  37. Yuan,N., Jia,L. and Zhu,J.
    Label-free Fluorescence Turn on Trypsin Assay Based on Gemini Surfactant/heparin/Nile Red Supramolecular Assembly
    J Fluoresc31, 1537-1545. PubMed  Europe PubMed DOI
    38. 2020
  38. Ahmed Al-Hadhrami,N., Ladwig,A., Rahman,A., Rozas,I., Paul,G.M. and Evans,P.
    Synthesis of 2-guanidinyl pyridines and their trypsin inhibition and docking
    Bioorg Med Chem28, 115612-115612. PubMed  Europe PubMed DOI
  39. Bubis,J.A., Gorshkov,V., Gorshkov,M.V. and Kjeldsen,F.
    PhosphoShield: Improving Trypsin Digestion of Phosphoproteins by Shielding the Negatively Charged Phosphate Moiety
    J Am Soc Mass Spectrom PubMed  Europe PubMed DOI
  40. Chen,X., Chen,D., Huang,L., Chen,X., Zhou,M., Xi,X., Ma,C., Chen,T. and Wang,L.
    Identification and Target-Modification of SL-BBI: A Novel Bowman-Birk Type Trypsin Inhibitor from Sylvirana latouchii
    Biomolecules10, PubMed  Europe PubMed DOI
  41. Dau,T., Bartolomucci,G. and Rappsilber,J.
    Proteomics Using Protease Alternatives to Trypsin Benefits from Sequential Digestion with Trypsin
    Anal Chem92, 9523-9527. PubMed  Europe PubMed DOI
  42. Duan,X., Li,N., Wang,G. and Su,X.
    High sensitive ratiometric fluorescence analysis of trypsin and dithiothreitol based on WS2 QDs
    Talanta219, 121171-121171. PubMed  Europe PubMed DOI
  43. Estaras,M., Ameur,F.Z., Estevez,M., Diaz-Velasco,S. and Gonzalez,A.
    The lysine derivative aminoadipic acid, a biomarker of protein oxidation and diabetes-risk, induces production of reactive oxygen species and impairs trypsin secretion in mouse pancreatic acinar cells
    Food Chem Toxicol111594-111594. PubMed  Europe PubMed DOI
  44. Hu,Q., Bao,Y., Gan,S., Zhang,Y., Han,D. and Niu,L.
    Electrochemically controlled grafting of polymers for ultrasensitive electrochemical assay of trypsin activity
    Biosens Bioelectron165, 112358-112358. PubMed  Europe PubMed DOI
  45. Jaimes,J., Millet,J. and Whittaker,G.
    Proteolytic Cleavage of the SARS-CoV-2 Spike Protein and the Role of the Novel S1/S2 Site
    SSRN3581359-3581359. PubMed  Europe PubMed DOI
  46. Kahler,U., Kamenik,A.S., Waibl,F., Kraml,J. and Liedl,K.R.
    Protein-Protein Binding as a Two-Step Mechanism: Preselection of Encounter Poses during the Binding of BPTI and Trypsin
    Biophys J119, 652-666. PubMed  Europe PubMed DOI
  47. Ma,H., Zou,T., Li,H. and Cheng,H.
    The interaction of sodium dodecyl sulfate with trypsin: Multi-spectroscopic analysis, molecular docking, and molecular dynamics simulation
    Int J Biol Macromol PubMed  Europe PubMed DOI
  48. Melikishvili,S., Dizon,M. and Hianik,T.
    Application of high-resolution ultrasonic spectroscopy for real-time monitoring of trypsin activity in beta-casein solution
    Food Chem337, 127759-127759. PubMed  Europe PubMed DOI
  49. Millan-Martin,S., Jakes,C., Carillo,S., Buchanan,T., Guender,M., Kristensen,D.B., Sloth,T.M., Orgaard,M., Cook,K. and Bones,J.
    Inter-laboratory study of an optimised peptide mapping workflow using automated trypsin digestion for monitoring monoclonal antibody product quality attributes
    Anal Bioanal Chem PubMed  Europe PubMed DOI
  50. Mourao,C.B.F., Brand,G.D., Fernandes,J.P.C., Prates,M.V., Bloch,C., Jr., Barbosa,J.A.R.G., Freitas,S.M., Restano-Cassulini,R., Possani,L.D. and Schwartz,E.F.
    Head-to-Tail Cyclization after Interaction with Trypsin: A Scorpion Venom Peptide that Resembles Plant Cyclotides
    J Med Chem PubMed  Europe PubMed DOI
  51. Nanjundaiah,S.N., Ma,J., Sukumaran,S. and Sambasivam,G.
    Development of clone with novel TrpE fusion tag in E. coli for overexpression of trypsin in a bench-scale bioreactor
    Prep Biochem Biotechnol1-9. PubMed  Europe PubMed DOI
  52. Niu,B., Martinelli Ii,M., Jiao,Y., Wang,C., Cao,M., Wang,J. and Meinke,E.
    Nonspecific cleavages arising from reconstitution of trypsin under mildly acidic conditions
    PLoS ONE15, e0236740-e0236740. PubMed  Europe PubMed DOI
  53. Retzl,B., Hellinger,R., Muratspahic,E., Pinto,M.E.F., Bolzani,V.S. and Gruber,C.W.
    Discovery of a Beetroot Protease Inhibitor to Identify and Classify Plant-Derived Cystine Knot Peptides
    J Nat Prod PubMed  Europe PubMed DOI
  54. Smith,D., Cwiklinski,K., Jewhurst,H., Tikhonova,I.G. and Dalton,J.P.
    An atypical and functionally diverse family of Kunitz-type cysteine/serine proteinase inhibitors secreted by the helminth parasite Fasciola hepatica
    Sci Rep10, 20657-20657. PubMed  Europe PubMed DOI
  55. Totsch,N. and Hoffmann,D.
    Bayesian Data Integration Questions Classic Study on Protease Self-Digest Kinetics
    ACS Omega5, 15162-15168. PubMed  Europe PubMed DOI
    56. 2018
  56. Gallegos,D.A., Sauri,J., Cohen,R.D., Wan,X., Videau,P., Vallota-Eastman,A.O., Shaala,L.A., Youssef,D.T.A., Williamson,R.T., Martin,G.E., Philmus,B., Sikora,A.E., Ishmael,J.E. and McPhail,K.L.
    Jizanpeptins, cyanobacterial protease inhibitors from a Symploca sp. cyanobacterium collected in the Red Sea
    J Nat Prod81, 1417-1425. PubMed  Europe PubMed DOI  I
  57. Liu,L., Yu,H., Du,K., Wang,Z., Gan,Y. and Huang,H.
    Enhanced trypsin thermostability in Pichia pastoris through truncating the flexible region
    Microb Cell Fact17, 165-165. PubMed  Europe PubMed DOI
  58. Perutka,Z. and Sebela,M.
    Pseudotrypsin: a little-known trypsin proteoform
    Molecules23, PubMed  Europe PubMed DOI
  59. Sato,D., Kondo,T. and Kato,T.
    Dual emissive bispyrene peptide probes for highly sensitive measurements of trypsin activity and evaluation of trypsin inhibitors
    Bioorg Med Chem26, 3468-3473. PubMed  Europe PubMed DOI  A
  60. Schiebel,J., Gaspari,R., Wulsdorf,T., Ngo,K., Sohn,C., Schrader,T.E., Cavalli,A., Ostermann,A., Heine,A. and Klebe,G.
    Intriguing role of water in protein-ligand binding studied by neutron crystallography on trypsin complexes
    Nat Commun9, 3559-3559. PubMed  Europe PubMed DOI  S
  61. Wang,M., Su,D., Wang,G. and Su,X.
    A fluorometric sensing method for sensitive detection of trypsin and its inhibitor based on gold nanoclusters and gold nanoparticles
    Anal Bioanal Chem410, 6891-6900. PubMed  Europe PubMed DOI  A
  62. Wang,Y., Zhou,L., Kang,Q. and Yu,L.
    Simple and label-free liquid crystal-based sensor for detecting trypsin coupled to the interaction between cationic surfactant and BSA
    Talanta183, 223-227. PubMed  Europe PubMed DOI  A
    63. 2017
  63. Aithal,M., PavanKumar,N.N., Buddha,M., UmamaheshwaraRao,K. and Hazra,P.
    Kinetic and structural differentiation of trypsin from different origins
    BioPharm Int30, 38-43, 56.
  64. Liu,B., Xiao,H., Li,J., Geng,S., Ma,H. and Liang,G.
    Interaction of phenolic acids with trypsin: experimental and molecular modeling studies
    Food Chem228, 1-6. PubMed  Europe PubMed DOI  I
  65. Momeni,L., Mahmodian,S., Shareghi,B., Saboury,A.A. and Farhadian,S.
    The functional and structural stabilization of trypsin by sucrose
    Int J Biol Macromol99, 343-349. PubMed  Europe PubMed DOI
  66. Wu,M., Wang,X., Wang,K. and Guo,Z.
    An ultrasensitive fluorescent nanosensor for trypsin based on upconversion nanoparticles
    Talanta174, 797-802. PubMed  Europe PubMed DOI  A
  67. Xia,T., Ma,Q., Hu,T. and Su,X.
    A novel magnetic/photoluminescence bifunctional nanohybrid for the determination of trypsin
    Talanta170, 286-290. PubMed  Europe PubMed DOI  A
  68. Zhao,D., Chen,C., Zhao,J., Sun,J. and Yang,X.
    Label-free fluorescence turn-on strategy for trypsin activity based on thiolate-protected gold nanoclusters with bovine serum albumin as the substrate
    Sens Actuators, B Chem247, 392-399. DOI  A
    69. 2016
  69. Andre,J., Saleh,D., Syldatk,C. and Hausmann,R.
    Effect of spacer modification on enzymatic synthetic and hydrolytic activities of immobilized trypsin
    J Mol Catal B Enzym125, 88-96. DOI
  70. Cleary,J.A. and Malthouse,J.P.G.
    A new lysine derived glyoxal inhibitor of trypsin, its properties and utilization for studying the stabilization of tetrahedral adducts by trypsin
    Biochem Biophys Rep5, 272-284. PubMed  Europe PubMed DOI  I
  71. Erturk,G., Hedstrom,M. and Mattiasson,B.
    A sensitive and real-time assay of trypsin by using molecular imprinting-based capacitive biosensor
    Biosens Bioelectron86, 557-565. PubMed  Europe PubMed DOI  A
  72. Pazhang,M., Mehrnejad,F., Pazhang,Y., Falahati,H. and Chaparzadeh,N.
    Effect of sorbitol and glycerol on the stability of trypsin and difference between their stabilization effects in the various solvents
    Biotechnol Appl Biochem63, 206-213. PubMed  Europe PubMed DOI
  73. Raskovic,B., Vatic,S., Andelkovic,B., Blagojevic,V. and Polovic,N.
    Optimizing storage conditions to prevent cold denaturation of trypsin for sequencing and to prolong its shelf life
    Biochem Eng J105, 168-176. DOI
  74. Schittmayer,M., Fritz,K., Liesinger,L., Griss,J. and Birner-Gruenberger,R.
    Cleaning out the litterbox of proteomic scientists' favorite pet: optimized data analysis avoiding trypsin artifacts
    J Proteome Res15, 1222-1229. PubMed  Europe PubMed DOI
  75. Zeng,H.J., Wang,Y.P., Yang,R., You,J. and Qu,L.B.
    Inhibitory effects of daidzein and genistein on trypsin: insights from spectroscopic and molecular docking studies
    Int J Biol Macromol89, 336-343. PubMed  Europe PubMed DOI  I
  76. Zhao,X.-R., Chen,Y.-L., Wang,L., Wang,W.-F. and Chen,X.-G.
    Highly sensitive fluorescence detection of trypsin based on gold nanoparticle probes
    Anal Methods8, 393-400. DOI  A
    77. 2015
  77. Aguirre,C., Condado-Morales,I., Olguin,L.F. and Costas,M.
    Isothermal titration calorimetry determination of individual rate constants of trypsin catalytic activity
    Anal Biochem479, 18-27. PubMed  Europe PubMed DOI
  78. Batt,A.R., St Germain,C.P., Gokey,T., Guliaev,A.B. and Baird,T., Jr.
    Engineering trypsin for inhibitor resistance
    Protein Sci24, 1463-1474. PubMed  Europe PubMed DOI
  79. Burke,M.C., Wang,Y., Lee,A.E., Dixon,E.K., Castaneda,C.A., Fushman,D. and Fenselau,C.
    Unexpected trypsin cleavage at ubiquitinated lysines
    Anal Chem87, 8144-8148. PubMed  Europe PubMed DOI
  80. Cui,F., Yang,K. and Li,Y.
    Investigate the binding of catechins to trypsin using docking and molecular dynamics simulation
    PLoS ONE10, e0125848- PubMed  Europe PubMed DOI  I
  81. Ding,X. and Yang,K.L.
    Quantitative serine protease assays based on formation of copper(II)-oligopeptide complexes
    Analyst140, 340-345. PubMed  Europe PubMed DOI  A
  82. Dong,M., Qi,H., Ding,S. and Li,M.
    Electrochemical determination of trypsin using a heptapeptide substrate self-assembled on a gold electrode
    Mikrochim Acta182, 43-49. DOI  A
  83. Dycka,F., Franc,V., Frycak,P., Raus,M., Rehulka,P., Lenobel,R., Allmaier,G., Marchetti-Deschmann,M. and Sebela,M.
    Evaluation of pseudotrypsin cleavage specificity towards proteins by MALDI-TOF mass spectrometry
    Protein Pept Lett22, 1123-1132. PubMed  Europe PubMed  P
  84. Gizurarson,J.G. and Filippusson,H.
    Conjugation of d-glucosamine to bovine trypsin increases thermal stability and alters functional properties
    Enzyme Microb Technol75-76, 1-9. PubMed  Europe PubMed DOI
  85. Khangembam,B.K. and Chakrabarti,R.
    Trypsin from the digestive system of carp Cirrhinus mrigala: purification, characterization and its potential application
    Food Chem175, 386-394. PubMed  Europe PubMed DOI
  86. Ou,L.J., Li,X.Y., Li,L.J., Liu,H.W., Sun,A.M. and Liu,K.J.
    A sensitive assay for trypsin using poly(thymine)-templated copper nanoparticles as fluorescent probes
    Analyst140, 1871-1875. PubMed  Europe PubMed DOI  A
  87. Pinto,S.C., Rodrigues,A.R., Saraiva,J.A. and Lopes-da-Silva,J.A.
    Catalytic activity of trypsin entrapped in electrospun poly(epsilon-caprolactone) nanofibers
    Enzyme Microb Technol79-80, 8-18. PubMed  Europe PubMed DOI
  88. Shu,M., Shen,W., Wang,X., Wang,F., Ma,L. and Zhai,C.
    Expression, activation and characterization of porcine trypsin in Pichia pastoris GS115
    Protein Expr Purif114, 149-155. PubMed  Europe PubMed DOI  E
  89. Slechtova,T., Gilar,M., Kalikova,K. and Tesarova,E.
    Insight into trypsin miscleavage: comparison of kinetic constants of problematic peptide sequences
    Anal Chem87, 7636-7643. PubMed  Europe PubMed DOI  P
  90. Yang,M., Huang,X., Zhang,Y.-W., Ping,X.-Q., Long,J. and Cao,R.-Y.
    Cloning and expression of porcine trypsin mutant gene in Escherichia coli and its activity analysis
    Chin J Pharm Biotechnol22, 283-287.  E
  91. Zhao,M., Wu,F. and Xu,P.
    Development of a rapid high-efficiency scalable process for acetylated Sus scrofa cationic trypsin production from Escherichia coli inclusion bodies
    Protein Expr Purif116, 120-126. PubMed  Europe PubMed DOI  E
    92. 2014
  92. Boechi,L., Pierce,L., Komives,E.A. and McCammon,J.A.
    Trypsinogen activation as observed in accelerated molecular dynamics simulations
    Protein Sci23, 1550-1558. PubMed  Europe PubMed DOI
  93. Buettner,K., Kreisig,T., Strater,N. and Zuchner,T.
    Protein surface charge of trypsinogen changes its activation pattern
    BMC Biotechnol14, 960-960. PubMed  Europe PubMed DOI
  94. Castello Serrano,I., Stoica,G., Matas Adams,A. and Palomares,E.
    Dual core quantum dots for highly quantitative ratiometric detection of trypsin activity in cystic fibrosis patients
    Nanoscale6, 13623-13629. PubMed  Europe PubMed DOI  A
  95. Ding,X., Ge,D. and Yang,K.-L.
    Colorimetric protease assay by using gold nanoparticles and oligopeptides
    Sens Actuators, B Chem201, 234-239. DOI  A
  96. Franke,L., Liebscher,S. and Bordusa,F.
    Engineering the oxyanion hole of trypsin for promoting the reverse of proteolysis
    J Pept Sci20, 128-136. PubMed  Europe PubMed DOI
  97. Gershon,P.D.
    Cleaved and missed sites for trypsin, Lys-C, and Lys-N can be predicted with high confidence on the basis of sequence context
    J Proteome Res13, 702-709. PubMed  Europe PubMed DOI  P
  98. Hong,M.L., Li,L.J., Han,H.X. and Chu,X.
    A label-free fluorescence assay for trypsin based on the electron transfer between oligonucleotide-stabilized ag nanoclusters and cytochrome c
    Anal Sci30, 811-815. PubMed  Europe PubMed  A
  99. Kim,N.-S., Yu,H.-Y., Chung,N.-D., Kwon,T.-H. and Yang,M.-S.
    High-level production of recombinant trypsin in transgenic rice cell culture through utilization of an alternative carbon source and recycling system
    Enzyme Microb Technol63, 21-27. PubMed  Europe PubMed DOI  E
  100. Lacerda,C.D., Teixeira,A.E., Oliveira,J.S., Silva,S.F., Vasconcelos,A.V., Gouveia,D.G., Silva,A.R., Santoro,M.M., Mares-Guia,M.L. and Santos,A.M.
    Gamma trypsin: Purification and physicochemical characterization of a novel bovine trypsin isoform
    Int J Biol Macromol70, 179-186. PubMed  Europe PubMed DOI
  101. Liebscher,S., Schopfel,M., Aumuller,T., Sharkhuukhen,A., Pech,A., Hoss,E., Parthier,C., Jahreis,G., Stubbs,M.T. and Bordusa,F.
    N-Terminal protein modification by substrate-activated reverse proteolysis
    Angew Chem Int Ed Engl53, 3024-3028. PubMed  Europe PubMed DOI
  102. Pan,Y., Cheng,K., Mao,J., Liu,F., Liu,J., Ye,M. and Zou,H.
    Quantitative proteomics reveals the kinetics of trypsin-catalyzed protein digestion
    Anal Bioanal Chem406, 6247-6256. PubMed  Europe PubMed DOI  P
  103. Weiz,A.R., Ishida,K., Quitterer,F., Meyer,S., Kehr,J.C., Muller,K.M., Groll,M., Hertweck,C. and Dittmann,E.
    Harnessing the evolvability of tricyclic microviridins to dissect protease-inhibitor interactions
    Angew Chem Int Ed Engl53, 3735-3738. PubMed  Europe PubMed DOI  S  I
    104. 2013
  104. Bunkenborg,J., Espadas,G. and Molina,H.
    Cutting edge proteomics: benchmarking of six commercial trypsins
    J Proteome Res12, 3631-3641. PubMed  Europe PubMed DOI  P
  105. Crowell,A.M., Stewart,E.J., Take,Z.S. and Doucette,A.A.
    Critical assessment of the spectroscopic activity assay for monitoring trypsin activity in organic-aqueous solvent
    Anal Biochem435, 131-136. PubMed  Europe PubMed DOI  A
  106. Ganachaud,C., Bernin,D., Isaksson,D. and Holmberg,K.
    An anomalous behavior of trypsin immobilized in alginate network
    Appl Microbiol Biotechnol97, 4403-4414. PubMed  Europe PubMed DOI
  107. Karna,N., Debowski,D., Gitlin,A., Legowska,A. and Rolka,K.
    Investigation of peptide splicing using two-peptide-chain analogs of trypsin inhibitor SFTI-1
    FEBS J280, 6213-6222. PubMed  Europe PubMed DOI
  108. Liebschner,D., Dauter,M., Brzuszkiewicz,A. and Dauter,Z.
    On the reproducibility of protein crystal structures: five atomic resolution structures of trypsin
    Acta Crystallogr D Biol Crystallogr69, 1447-1462. PubMed  Europe PubMed DOI  S
  109. Liu,F., Ye,M., Wang,C., Hu,Z., Zhang,Y., Qin,H., Cheng,K. and Zou,H.
    Polyacrylamide gel with switchable trypsin activity for analysis of proteins
    Anal Chem85, 7024-7028. PubMed  Europe PubMed DOI
  110. Masuda,Y., Nitanai,Y., Mizutani,R. and Noguchi,S.
    Crystal structure of 6-guanidinohexanoyl trypsin near the optimum pH reveals the acyl-enzyme intermediate to be deacylated
    Proteins81, 526-530. PubMed  Europe PubMed DOI  S
  111. Meng,Y., Yuan,Y., Zhu,Y., Guo,Y., Li,M., Wang,Z., Pu,X. and Jiang,L.
    Effects of organic solvents and substrate binding on trypsin in acetonitrile and hexane media
    J Mol Model19, 3749-3766. PubMed  Europe PubMed DOI
  112. Vandermarliere,E., Mueller,M. and Martens,L.
    Getting intimate with trypsin, the leading protease in proteomics
    Mass Spectrom Rev32, 453-465. PubMed  Europe PubMed DOI  P
  113. Zhang,H., Zhou,Q., Cao,J. and Wang,Y.
    Mechanism of cinnamic acid-induced trypsin inhibition: a multi-technique approach
    Spectrochim Acta A Mol Biomol Spectrosc116, 251-257. PubMed  Europe PubMed DOI
  114. Zheng,H., Mei,Y.J., Du,K., Shi,Q.Y. and Zhang,P.F.
    Trypsin-catalyzed one-pot multicomponent synthesis of 4-thiazolidinones
    Catal Lett143, 298-301. DOI
    115. 2012
  115. Baird,T.T., Jr. and Craik,C.S.
    Trypsin
    [ISSN:978-0-12-407742-3]3, 2594-2600. DOI
  116. Dosa,S., Stirnberg,M., Lulsdorff,V., Haussler,D., Maurer,E. and Gutschow,M.
    Active site mapping of trypsin, thrombin and matriptase-2 by sulfamoyl benzamidines
    Bioorg Med Chem20, 6489-6505. PubMed  Europe PubMed DOI  I
  117. Gokey,T., Baird,T.T., Jr. and Guliaev,A.B.
    Conformational dynamics of threonine 195 and the S1 subsite in functional trypsin variants
    J Mol Model18, 4941-4954. PubMed  Europe PubMed DOI
  118. Salameh,M.A., Soares,A.S., Alloy,A. and Radisky,E.S.
    Presence versus absence of hydrogen bond donor Tyr-39 influences interactions of cationic trypsin and mesotrypsin with protein protease inhibitors
    Protein Sci21, 1103-1112. PubMed  Europe PubMed DOI  S
    119. 2011
  119. Brandt,T., Holzmann,N., Muley,L., Khayat,M., Wegscheid-Gerlach,C., Baum,B., Heine,A., Hangauer,D. and Klebe,G.
    Congeneric but still distinct: how closely related trypsin ligands exhibit different thermodynamic and structural properties
    J Mol Biol405, 1170-1187. PubMed  Europe PubMed DOI  I
  120. Iyaguchi,D.
    Inhibition mechanism of trypsin by Schiff base metal chelate inhibitors
    Yakugaku Zasshi131, 1299-1303. PubMed  Europe PubMed DOI  I
  121. Kawamura,K., Yamada,T., Kurihara,K., Tamada,T., Kuroki,R., Tanaka,I., Takahashi,H. and Niimura,N.
    X-ray and neutron protein crystallographic analysis of the trypsin-BPTI complex
    Acta Crystallogr D Biol Crystallogr67, 140-148. PubMed  Europe PubMed DOI  S
  122. Kim,N.S., Yu,H.Y., Chung,N.D., Shin,Y.J., Kwon,T.H. and Yang,M.S.
    Production of functional recombinant bovine trypsin in transgenic rice cell suspension cultures
    Protein Expr Purif76, 121-126. PubMed  Europe PubMed DOI  E
  123. Li,P., Liu,Y., Wang,X. and Tang,B.
    A new FRET nanoprobe for trypsin using a bridged beta-cyclodextrin dimer-dye complex and its biological imaging applications
    Analyst136, 4520-4525. PubMed  Europe PubMed DOI
  124. Marques,D., Pessela,B.C., Betancor,L., Monti,R., Carrascosa,A.V., Rocha-Martin,J., Guisan,J.M. and Fernandez-Lorente,G.
    Protein hydrolysis by immobilized and stabilized trypsin
    Biotechnol Prog27, 677-683. PubMed  Europe PubMed DOI
  125. Mu,Y., Lin,J. and Liu,R.
    Interaction of sodium benzoate with trypsin by spectroscopic techniques
    Spectrochim Acta A Mol Biomol Spectrosc83, 130-135. PubMed  Europe PubMed DOI
  126. Ray,K. and Jalili,P.R.
    Characterization of TrypZean: a plant-based alternative to bovine-derived trypsin
    BioPharm Int24, 44-48.  E
  127. Ruark,C.D., Hack,C.E., Robinson,P.J. and Gearhart,J.M.
    Quantitative structure-activity relationships for organophosphates binding to trypsin and chymotrypsin
    J Toxicol Environ Health A74, 1-23. PubMed  Europe PubMed DOI  I
  128. Schopfel,M., Tziridis,A., Arnold,U. and Stubbs,M.T.
    Towards a restriction proteinase: construction of a self-activating enzyme
    Chembiochem12, 1523-1527. PubMed  Europe PubMed DOI
  129. Wahlgren,W.Y., Pal,G., Kardos,J., Porrogi,P., Szenthe,B., Patthy,A., Graf,L. and Katona,G.
    The catalytic aspartate is protonated in the Michaelis complex formed between trypsin and an in vitro evolved substrate-like inhibitor: a refined mechanism of serine protease action
    J Biol Chem286, 3587-3596. PubMed  Europe PubMed DOI  S
  130. Xue,W., Zhang,G. and Zhang,D.
    A sensitive colorimetric label-free assay for trypsin and inhibitor screening with gold nanoparticles
    Analyst136, 3136-3141. PubMed  Europe PubMed DOI  A
  131. Zhou,Y. and Zhang,Y.
    Serine protease acylation proceeds with a subtle re-orientation of the histidine ring at the tetrahedral intermediate
    Chem Commun (Camb)47, 1577-1579. PubMed  Europe PubMed DOI
    132. 2010
  132. Chai,S.J., Lai,Y.F., Zheng,H. and Zhang,P.F.
    A novel trypsin-catalyzed three-component Mannich reaction
    Helv Chim Acta93, 2231-2236. DOI
  133. Kawamura,K., Yamada,T., Kurihara,K., Tamada,T., Kuroki,R., Tanaka,I., Takahashi,H. and Niimura,N.
    A preliminary neutron crystallography on the trypsin-bovine pancreatic trypsin inhibitor complex
    J Phys Conf Ser251, 012033-012033. DOI  S
  134. Mannocci,L., Melkko,S., Buller,F., Molnar,I., Bianke,J.P., Dumelin,C.E., Scheuermann,J. and Neri,D.
    Isolation of potent and specific trypsin inhibitors from a DNA-encoded chemical library
    Bioconjug Chem21, 1836-1841. PubMed  Europe PubMed DOI  I
  135. Wartmann,T., Mayerle,J., Kahne,T., Sahin-Toth,M., Ruthenburger,M., Matthias,R., Kruse,A., Reinheckel,T., Peters,C., Weiss,F.U., Sendler,M., Lippert,H., Schulz,H.U., Aghdassi,A., Dummer,A., Teller,S., Halangk,W. and Lerch,M.M.
    Cathepsin L inactivates human trypsinogen, whereas cathepsin L-deletion reduces the severity of pancreatitis in mice
    Gastroenterology138, 726-737. PubMed  Europe PubMed DOI
  136. Zhang,H., Huang,R.Y., Jalili,P.R., Irungu,J.W., Nicol,G.R., Ray,K.B., Rohrs,H.W. and Gross,M.L.
    Improved mass spectrometric characterization of protein glycosylation reveals unusual glycosylation of maize-derived bovine trypsin
    Anal Chem82, 10095-10101. PubMed  Europe PubMed DOI  E
    137. 2009
  137. Di Cera,E.
    Serine proteases
    IUBMB Life61, 510-515. PubMed  Europe PubMed DOI  V
  138. Kereszturi,E., Szmola,R., Kukor,Z., Simon,P., Weiss,F.U., Lerch,M.M. and Sahin-Toth,M.
    Hereditary pancreatitis caused by mutation-induced misfolding of human cationic trypsinogen: a novel disease mechanism
    Hum Mutat30, 575-582. PubMed  Europe PubMed DOI  M
  139. Zakharova,E., Horvath,M.P. and Goldenberg,D.P.
    Structure of a serine protease poised to resynthesize a peptide bond
    Proc Natl Acad Sci U S A106, 11034-11039. PubMed  Europe PubMed DOI
    140. 2008
  140. Gombos,L., Kardos,J., Patthy,A., Medveczky,P., Szilagyi,L., Malnasi-Csizmadia,A. and Graf,L.
    Probing conformational plasticity of the activation domain of trypsin: the role of glycine hinges
    Biochemistry47, 1675-1684. PubMed  Europe PubMed DOI
  141. Rodriguez,J., Gupta,N., Smith,R.D. and Pevzner,P.A.
    Does trypsin cut before proline?
    J Proteome Res7, 300-305. PubMed  Europe PubMed DOI  P
    142. 2007
  142. Baumann,H.I., Keller,S., Wolter,F.E., Nicholson,G.J., Jung,G., Sussmuth,R.D. and Juttner,F.
    Planktocyclin, a cyclooctapeptide protease inhibitor produced by the freshwater cyanobacterium Planktothrix rubescens
    J Nat Prod70, 1611-1615. PubMed  Europe PubMed DOI  I
  143. Czodrowski,P., Sotriffer,C.A. and Klebe,G.
    Protonation changes upon ligand binding to trypsin and thrombin: structural interpretation based on pK(a) calculations and ITC experiments
    J Mol Biol367, 1347-1356. PubMed  Europe PubMed DOI
  144. Di Fenza,A., Heine,A., Koert,U. and Klebe,G.
    Understanding binding selectivity toward trypsin and factor Xa: the role of aromatic interactions
    ChemMedChem2, 297-308. PubMed  Europe PubMed DOI  I
  145. Ito,T., Sugita,Y., Takao,K., Ikeguchi,Y. and Shirahata,A.
    Amine modification of digested peptide at C-terminal end during protein digestion by protease
    Biol Pharm Bull30, 1838-1843. PubMed  Europe PubMed DOI
  146. Manea,M., Mezo,G., Hudecz,F. and Przybylski,M.
    Mass spectrometric identification of the trypsin cleavage pathway in lysyl-proline containing oligotuftsin peptides
    J Pept Sci13, 227-236. PubMed  Europe PubMed DOI  P
  147. Sherawat,M., Kaur,P., Perbandt,M., Betzel,C., Slusarchyk,W.A., Bisacchi,G.S., Chang,C., Jacobson,B.L., Einspahr,H.M. and Singh,T.P.
    Structure of the complex of trypsin with a highly potent synthetic inhibitor at 0.97 A resolution
    Acta Crystallogr D Biol Crystallogr63, 500-507. PubMed  Europe PubMed DOI  S  I
    148. 2006
  148. [YEAR:22-9-2006]Angel,P.M. and Orlando,R.
    Trypsin is the primary mechanism by which the (18)O isotopic label is lost in quantitative proteomic studies
    Anal Biochem359, 26-34. PubMed  Europe PubMed DOI
  149. [YEAR:2-5-2006]Baird,T.T., Jr., Wright,W.D. and Craik,C.S.
    Conversion of trypsin to a functional threonine protease
    Protein Sci15, 1229-1238. PubMed  Europe PubMed DOI
  150. [YEAR:6-3-2006]Caracciolo,G., Martelli,A., Boumis,G., Bellelli,A., Caminiti,R., Congiu-Castellano,A. and Amiconi,G.
    Conformational changes of bovine beta-trypsin and trypsinogen induced by divalent ions: an energy-dispersive X-ray diffraction and functional study
    Arch Biochem Biophys449, 157-163. PubMed  Europe PubMed DOI
  151. [YEAR:2-5-2006]Ishida,T.
    Low-barrier hydrogen bond hypothesis in the catalytic triad residue of serine proteases: correlation between structural rearrangement and chemical shifts in the acylation process
    Biochemistry45, 5413-5420. PubMed  Europe PubMed DOI
  152. [YEAR:26-6-2006]Paul,J.J., Kircus,S.R., Sorrell,T.N., Ropp,P.A. and Thorp,H.H.
    Effects of coordinating metal Ions on the mediated inhibition of trypsin by bis(benzimidazoles) and related compounds
    Inorg Chem45, 5126-5135. PubMed  Europe PubMed DOI  I
  153. [YEAR:2-5-2006]Radisky,E.S., Lee,J.M., Lu,C.J. and Koshland,D.E., Jr.
    Insights into the serine protease mechanism from atomic resolution structures of trypsin reaction intermediates
    Proc Natl Acad Sci U S A103, 6835-6840. PubMed  Europe PubMed DOI  S
  154. Shibli,A., Smoum,R., Goldberg,I., Rubinstein,A. and Srebnik,M.
    alpha-Amino boronates as cyanoborane complexes: crystal structure and inhibition properties for the serine proteases: alpha-chymotrypsin and trypsin
    Appl Organomet Chem20, 459-462. DOI  S  I
  155. Transue,T.R., Gabel,S.A. and London,R.E.
    NMR and crystallographic characterization of adventitious borate binding by trypsin
    Bioconjug Chem17, 300-308. PubMed  Europe PubMed DOI  S  I
    156. 2005
  156. [YEAR:1-2-2005]Guvench,O., Price,D.J. and Brooks,C.L., III
    Receptor rigidity and ligand mobility in trypsin-ligand complexes
    Proteins58, 407-417. PubMed  Europe PubMed DOI
  157. Shamaladevi,N. and Pattabhi,V.
    Secondary binding site of trypsin: revealed by crystal structure of trypsin-peptide complex
    J Biomol Struct Dyn22, 635-642. PubMed  Europe PubMed DOI  S
  158. [YEAR:5-8-2005]Yang,L., Gao,Z., Cao,Y., Xing,R. and Zhang,X.
    Effect of PbII on the secondary structure and biological activity of trypsin
    Chembiochem6, 1191-1195. PubMed  Europe PubMed DOI
    159. 2004
  159. Halfon,S., Baird,T.T., Jr. and Craik,C.S.
    Trypsin
    [ISSN:0-12-079610-4]2, 1483-1488.  V
  160. [YEAR:1-4-2004]Khajehpour,M., Troxler,T. and Vanderkooi,J.M.
    Probing the active site of trypsin with rose bengal: insights into the photodynamic inactivation of the enzyme
    Photochem Photobiol80, 359-365. PubMed  Europe PubMed DOI
  161. Leiros,H.K., Brandsdal,B.O., Andersen,O.A., Os,V., Leiros,I., Helland,R., Otlewski,J., Willassen,N.P. and Smalas,A.O.
    Trypsin specificity as elucidated by LIE calculations, X-ray structures, and association constant measurements
    Protein Sci13, 1056-1070. PubMed  Europe PubMed DOI  S
  162. [YEAR:19-3-2004]Olsen,J.V., Ong,S.E. and Mann,M.
    Trypsin cleaves exclusively C-terminal to arginine and lysine residues
    Mol Cell Proteomics3, 608-614. PubMed  Europe PubMed DOI
  163. Rauh,D., Klebe,G. and Stubbs,M.T.
    Understanding protein-ligand interactions: the price of protein flexibility
    J Mol Biol335, 1325-1341. PubMed  Europe PubMed DOI  S
  164. Transue,T.R., Krahn,J.M., Gabel,S.A., DeRose,E.F. and London,R.E.
    X-ray and NMR characterization of covalent complexes of trypsin, borate, and alcohols
    Biochemistry43, 2829-2839. PubMed  Europe PubMed DOI  S  I
  165. [YEAR:18-6-2004]Zablotna,E., Dysasz,H., Lesner,A., Jaskiewicz,A., Kazmierczak,K., Miecznikowska,H. and Rolka,K.
    A simple method for selection of trypsin chromogenic substrates using combinatorial chemistry approach
    Biochem Biophys Res Commun319, 185-188. PubMed  Europe PubMed DOI  A
    166. 2003
  166. Chen,J.M., Kukor,Z., Le Marechal,C., Toth,M., Tsakiris,L., Raguenes,O., Ferec,C. and Sahin-Toth,M.
    Evolution of trypsinogen activation peptides
    Mol Biol Evol20, 1767-1777. PubMed  Europe PubMed DOI
  167. Hanquier,J., Sorlet,Y., Desplancq,D., Baroche,L., Ebtinger,M., Lefevre,J.F., Pattus,F., Hershberger,C.L. and Vertes,A.A.
    A single mutation in the activation site of bovine trypsinogen enhances its accumulation in the fermentation broth of the yeast Pichia pastoris
    Appl Environ Microbiol69, 1108-1113. PubMed  Europe PubMed DOI  E
  168. [YEAR:31-10-2003]Helland,R., Czapinska,H., Leiros,I., Olufsen,M., Otlewski,J. and Smalas,A.O.
    Structural consequences of accommodation of four non-cognate amino acid residues in the S1 pocket of bovine trypsin and chymotrypsin
    J Mol Biol333, 845-861. PubMed  Europe PubMed DOI
  169. [YEAR:31-10-2003]Schmidt,A., Jelsch,C., Ostergaard,P., Rypniewski,W. and Lamzin,V.S.
    Trypsin revisited: crystallography at (sub) atomic resolution and quantum chemistry revealing details of catalysis
    J Biol Chem278, 43357-43362. PubMed  Europe PubMed DOI  S
    170. 2002
  170. Bianchini,E.P., Louvain,V.B., Marque,P.E., Juliano,M.A., Juliano,L. and le Bonniec,B.F.
    Mapping of the catalytic groove preferences of factor Xa reveals an inadequate selectivity for its macromolecule substrates
    J Biol Chem277, 20527-20534. PubMed  Europe PubMed DOI  P
  171. Cuesta-Seijo,J.A. and Garcia-Granda,S.
    Trypsin as a model for high resolution X-ray diffraction in proteins
    Bol R Soc Hist Nat Sec Geol97, 123-129.
  172. Cui,J., Marankan,F., Fu,W., Crich,D., Mesecar,A. and Johnson,M.E.
    An oxyanion-hole selective serine protease inhibitor in complex with trypsin
    Bioorg Med Chem10, 41-46. PubMed  Europe PubMed DOI  S
  173. Johnson,K.D., Clark,A. and Marshall,S.
    A functional comparison of ovine and porcine trypsins
    Comp Biochem Physiol B Biochem Mol Biol131, 423-431. PubMed  Europe PubMed DOI  I
    174. 2001
  174. Darvesh,S., Kumar,R., Roberts,S., Walsh,R. and Martin,E.
    Butyrylcholinesterase-mediated enhancement of the enzymatic activity of trypsin
    Cell Mol Neurobiol21, 285-296. PubMed  Europe PubMed DOI
  175. Dormitzer,P.R., Greenberg,H.B. and Harrison,S.C.
    Proteolysis of monomeric recombinant rotavirus VP4 yields an oligomeric VP5*core
    J Virol75, 7339-7350. PubMed  Europe PubMed DOI
  176. Katz,B.A., Sprengeler,P.A., Luong,C., Verner,E., Elrod,K., Kirtley,M., Janc,J., Spencer,J.R., Breitenbucher,J.G., Hui,H., McGee,D., Allen,D., Martelli,A. and Mackman,R.L.
    Engineering inhibitors highly selective for the S1 sites of Ser190 trypsin-like serine protease drug targets
    Chem Biol8, 1107-1121. PubMed  Europe PubMed DOI  S
  177. Leiros,H.K., McSweeney,S.M. and Smalas,A.O.
    Atomic resolution structures of trypsin provide insight into structural radiation damage
    Acta Crystallogr D Biol Crystallogr57, 488-497. PubMed  Europe PubMed DOI  S
  178. [YEAR:3-8-2001]Lesner,A., Kupryszewski,G. and Rolka,K.
    Chromogenic substrates of bovine beta-trypsin: the influence of an amino acid residue in P1 position on their interaction with the enzyme
    Biochem Biophys Res Commun285, 1350-1353. PubMed  Europe PubMed DOI  A  P
  179. O'Reilly,D.A., Yang,B.M., Creighton,J.E., Demaine,A.G. and Kingsnorth,A.N.
    Mutations of the cationic trypsinogen gene in hereditary and non-hereditary pancreatitis
    Digestion64, 54-60. PubMed  Europe PubMed DOI  M
  180. Pasternak,A., White,A., Jeffery,C.J., Medina,N., Cahoon,M., Ringe,D. and Hedstrom,L.
    The energetic cost of induced fit catalysis: crystal structures of trypsinogen mutants with enhanced activity and inhibitor affinity
    Protein Sci10, 1331-1342. PubMed  Europe PubMed DOI
  181. Tomoo,K., Satoh,K., Tsuda,Y., Wanaka,K., Okamoto,S., Hijikata-Okunomiya,A., Okada,Y. and Ishida,T.
    Binding diversity of a noncovalent-type low-molecular-weight serine protease inhibitor and function of a catalytic water molecule: X-ray crystal structure of PKSI-527-inhibited trypsin
    J Biochem129, 455-460. PubMed  Europe PubMed  S  I
  182. [YEAR:19-1-2001]Toyota,E., Ng,K.K., Sekizaki,H., Itoh,K., Tanizawa,K. and James,M.N.
    X-ray crystallographic analyses of complexes between bovine beta-trypsin and Schiff base copper(II) or iron(III) chelates
    J Mol Biol305, 471-479. PubMed  Europe PubMed DOI  S
  183. [YEAR:9-3-2001]Xu,S., Rall,K. and Bordusa,F.
    Enzymatic coupling of specific peptides at nonspecific ligation sites: effect of Asp189Glu mutation in trypsin on substrate mimetic-mediated reactions
    J Org Chem66, 1627-1632. PubMed  Europe PubMed DOI
    184. 2000
  184. Bass,D.M. and Qiu,S.
    Proteolytic processing of the astrovirus capsid
    J Virol74, 1810-1814. PubMed  Europe PubMed DOI
  185. [YEAR:5-7-2000]Harris,J.L., Backes,B.J., Leonetti,F., Mahrus,S., Ellman,J.A. and Craik,C.S.
    Rapid and general profiling of protease specificity by using combinatorial fluorogenic substrate libraries
    Proc Natl Acad Sci U S A97, 7754-7759. PubMed  Europe PubMed DOI  P
  186. Hijikata-Okunomiya,A., Tamao,Y., Kikumoto,R. and Okamoto,S.
    Selective inhibition of trypsin by (2R,4R)-4-phenyl-1-[Nalpha-(7-methoxy-2-naphthalenesulfonyl)-L-arginyl]-2-piperidinecarboxylic acid
    J Biol Chem275, 18995-18999. PubMed  Europe PubMed DOI  I
  187. Katz,B.A., Mackman,R., Luong,C., Radika,K., Martelli,A., Sprengeler,P.A., Wang,J., Chan,H. and Wong,L.
    Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator
    Chem Biol7, 299-312. PubMed  Europe PubMed DOI  S
  188. Rester,U., Moser,M., Huber,R. and Bode,W.
    L-Isoaspartate 115 of porcine beta-trypsin promotes crystallization of its complex with bdellastasin
    Acta Crystallogr D Biol Crystallogr56, 581-588. PubMed  Europe PubMed DOI  S
    189. 1999
  189. [YEAR:16-11-1999]Johnson,A., Gautham,N. and Pattabhi,V.
    Crystal structure at 1.63 A resolution of the native form of porcine beta-trypsin: revealing an acetate ion binding site and functional water network
    Biochim Biophys Acta1435, 7-21. PubMed  Europe PubMed DOI  S
  190. Katz,B.A. and Luong,C.
    Recruiting Zn2+ to mediate potent, specific inhibition of serine proteases
    J Mol Biol292, 669-684. PubMed  Europe PubMed DOI  S  I
  191. Otani,T. and Matsukura,A.
    Cathepsin B inhibitors do not prevent the intracellular trypsinogen activation by secretagogue hyperstimulation
    Pancreas19, 210-211. PubMed  Europe PubMed  I
  192. Pasternak,A., Ringe,D. and Hedstrom,L.
    Comparison of anionic and cationic trypsinogens: the anionic activation domain is more flexible in solution and differs in its mode of BPTI binding in the crystal structure
    Protein Sci8, 253-258. PubMed  Europe PubMed DOI
  193. Polticelli,F., Ascenzi,P., Bolognesi,M. and Honig,B.
    Structural determinants of trypsin affinity and specificity for cationic inhibitors
    Protein Sci8, 2621-2629. PubMed  Europe PubMed DOI  I
  194. Recacha,R., Carson,M., Costanzo,M.J., Maryanoff,B., DeLucas,L.J. and Chattopadhyay,D.
    Structure of the RWJ-51084-bovine pancreatic beta-trypsin complex at 1.8 A
    Acta Crystallogr D Biol Crystallogr55, 1785-1791. PubMed  Europe PubMed DOI  S  I
  195. Szabo,E., Bocskei,Z., Naray-Szabo,G. and Graf,L.
    The three-dimensional structure of Asp189Ser trypsin provides evidence for an inherent structural plasticity of the protease
    Eur J Biochem263, 20-26. PubMed  Europe PubMed DOI
  196. [YEAR:8-1-1999]Wu,C., Robertson,D.H., Hubbard,S.J., Gaskell,S.J. and Beynon,R.J.
    Proteolysis of native proteins. Trapping of a reaction intermediate
    J Biol Chem274, 1108-1115. PubMed  Europe PubMed DOI
  197. Zhu,Y., Huang,Q., Qian,M., Jia,Y. and Tang,Y.
    Crystal structure of the complex formed between bovine beta-trypsin and MCTI-A, a trypsin inhibitor of squash family, at 1.8-A resolution
    J Protein Chem18, 505-509. PubMed  Europe PubMed DOI  S
    198. 1998
  198. Chobert,J.M., Briand,L. and Haertle,T.
    Influence of G187W/K188F/D189Y mutation in the substrate binding pocket of trypsin on beta-casein processing
    J Food Biochem22, 529-545. DOI
  199. [YEAR:15-12-1998]Grahn,S., Ullmann,D. and Jakubke,H.
    Design and synthesis of fluorogenic trypsin peptide substrates based on resonance energy transfer
    Anal Biochem265, 225-231. PubMed  Europe PubMed DOI  A
  200. Katz,B.A., Clark,J.M., Finer-Moore,J.S., Jenkins,T.E., Johnson,C.R., Ross,M.J., Luong,C., Moore,W.R. and Stroud,R.M.
    Design of potent selective zinc-mediated serine protease inhibitors
    Nature391, 608-612. PubMed  Europe PubMed DOI  S  I
  201. Krishnan,R., Zhang,E., Hakansson,K., Arni,R.K., Tulinsky,A., Lim-Wilby,M.S., Levy,O.E., Semple,J.E. and Brunck,T.K.
    Highly selective mechanism-based thrombin inhibitors: structures of thrombin and trypsin inhibited with rigid peptidyl aldehydes
    Biochemistry37, 12094-12103. PubMed  Europe PubMed DOI  S  I
  202. Ni,L.M. and Powers,J.C.
    Synthesis and kinetic studies of an amidine-containing phosphonofluoridate: a novel potent inhibitor of trypsin-like enzymes
    Bioorg Med Chem6, 1767-1773. PubMed  Europe PubMed DOI  I
  203. [YEAR:1-12-1998]Presnell,S.R., Patil,G.S., Mura,C., Jude,K.M., Conley,J.M., Bertrand,J.A., Kam,C.M., Powers,J.C. and Williams,L.D.
    Oxyanion-mediated inhibition of serine proteases
    Biochemistry37, 17068-17081. PubMed  Europe PubMed DOI  S  I
  204. Varallyay,E., Pal,G., Patthy,A., Szilagyi,L. and Graf,L.
    Two mutations in rat trypsin confer resistance against autolysis
    Biochem Biophys Res Commun243, 56-60. PubMed  Europe PubMed DOI
    205. 1997
  205. Kaslik,G., Kardos,J., Szabo,E., Szilagyi,L., Zavodszky,P., Westler,W.M., Markley,J.L. and Graf,L.
    Effects of serpin binding on the target proteinase: global stabilization, localized increased structural flexibility, and conserved hydrogen bonding at the active site
    Biochemistry36, 5455-5464. PubMed  Europe PubMed DOI
  206. Kurth,T., Ullmann,D., Jakubke,H.D. and Hedstrom,L.
    Converting trypsin to chymotrypsin: Structural determinants of S1' specificity
    Biochemistry36, 10098-10104. PubMed  Europe PubMed DOI
  207. Li,X.F., Tang,J.G. and Zhang,L.X.
    Autolytic site mutant R105C of rat trypsin
    Biochem Mol Biol Int42, 991-996. PubMed  Europe PubMed  E
  208. Roach,J.C., Wang,K., Gan,L. and Hood,L.
    The molecular evolution of the vertebrate trypsinogens
    J Mol Evol45, 640-652. PubMed  Europe PubMed DOI
  209. Takahashi,K.
    Restriction of the specificities of trypsin and alpha-chymotrypsin at a high alkaline pH value
    Protein Pept Lett4, 33-38.
  210. Varallyay,E., Lengyel,Z., Graf,L. and Szilagyi,L.
    The role of disulfide bond C191-C220 in trypsin and chymotrypsin
    Biochem Biophys Res Commun230, 592-596. PubMed  Europe PubMed DOI
    211. 1996
  211. [YEAR:12-3-1996]Bertrand,J.A., Oleksyszyn,J., Kam,C.M., Boduszek,B., Presnell,S., Plaskon,R.R., Suddath,F.L., Powers,J.C. and Williams,L.D.
    Inhibition of trypsin and thrombin by amino(4-amidinophenyl)methanephosphonate diphenyl ester derivatives: X-ray structures and molecular models
    Biochemistry35, 3147-3155. PubMed  Europe PubMed DOI  S  I
  212. Hedstrom,L., Lin,T.Y. and Fast,W.
    Hydrophobic interactions control zymogen activation in the trypsin family of serine proteases
    Biochemistry35, 4515-4523. PubMed  Europe PubMed DOI
  213. Hedstrom,L.
    Trypsin: a case study in the structural determinants of enzyme specificity
    Biol Chem377, 465-470. PubMed  Europe PubMed
  214. Kurinov,I.V. and Harrison,R.W.
    Two crystal structures of the leupeptin-trypsin complex
    Protein Sci5, 752-758. PubMed  Europe PubMed DOI  S  I
  215. Sreedharan,S.K., Verma,C., Caves,L.S., Brocklehurst,S.M., Gharbia,S.E., Shah,H.N. and Brocklehurst,K.
    Demonstration that 1-trans-epoxysuccinyl-L-leucylamido- (4-guanidino)butane (E-64) is one of the most effective low Mr inhibitors of trypsin-catalysed hydrolysis. Characterization by kinetic analysis and by energy minimization and molecular dynamics simulation of the E-64-beta-trypsin complex
    Biochem J316, 777-786. PubMed  Europe PubMed  I
    216. 1995
  216. Matsuzaki,T., Umeyama,H. and Kikumoto,R.
    Mechanisms of the selective inhibition of thrombin, factor Xa, plasmin and trypsin
    Pharmacochem Libr23, 83-95. DOI  S  I
  217. Odagaki,Y., Nakai,H., Senokuchi,K., Kawamura,M., Hamanaka,N., Nakamura,M., Tomoo,K. and Ishida,T.
    Unique binding of a novel synthetic inhibitor, N-[3-[4-[4-(amidinophenoxy)carbonyl]phenyl]-2-methyl-2-propenoyl]-N-allylglycine methanesulfonate, to bovine trypsin, revealed by the crystal structure of the complex
    Biochemistry34, 12849-12853. PubMed  Europe PubMed DOI  S  I
    218. 1994
  218. [YEAR:26-7-1994]Hedstrom,L., Farr-Jones,S., Kettner,C.A. and Rutter,W.J.
    Converting trypsin to chymotrypsin: ground-state binding does not determine substrate specificity
    Biochemistry33, 8764-8769. PubMed  Europe PubMed DOI  I
  219. [YEAR:26-7-1994]Hedstrom,L., Perona,J.J. and Rutter,W.J.
    Converting trypsin to chymotrypsin: residue 172 is a substrate specificity determinant
    Biochemistry33, 8757-8763. PubMed  Europe PubMed DOI
  220. Huang,Q., Wang,Z., Li,Y., Liu,S. and Tang,Y.
    Refined 1.8 A resolution crystal structure of the porcine epsilon-trypsin
    Biochim Biophys Acta1209, 77-82. PubMed  Europe PubMed DOI  S
  221. Lee,A.Y., Smitka,T.A., Bonjouklian,R. and Clardy,J.
    Atomic structure of the trypsin-A90720A complex: a unified approach to structure and function
    Chem Biol1, 113-117. PubMed  Europe PubMed DOI  S  I
  222. Rypniewski,W.R., Perrakis,A., Vorgias,C.E. and Wilson,K.S.
    Evolutionary divergence and conservation of trypsin
    Protein Eng7, 57-64. PubMed  Europe PubMed
  223. [YEAR:12-4-1994]Schellenberger,V., Turck,C.W. and Rutter,W.J.
    Role of the S' subsites in serine protease catalysis. Active-site mapping of rat chymotrypsin, rat trypsin, alpha-lytic protease, and cercarial protease from Schistosoma mansoni
    Biochemistry33, 4251-4257. PubMed  Europe PubMed
    224. 1992
  224. [YEAR:6-3-1992]Hedstrom,L., Szilagyi,L. and Rutter,W.J.
    Converting trypsin to chymotrypsin: the role of surface loops
    Science255, 1249-1253. PubMed  Europe PubMed
  225. Takeuchi,Y., Nonaka,T., Nakamura,K.T., Kojima,S., Miura,K. and Mitsui,Y.
    Crystal structure of an engineered subtilisin inhibitor complexed with bovine trypsin
    Proc Natl Acad Sci U S A89, 4407-4411. PubMed  Europe PubMed DOI  S
    226. 1990
  226. Chow,M.M., Meyer,E.F., Jr., Bode,W., Kam,C.M., Radhakrishnan,R., Vijayalakshmi,J. and Powers,J.C.
    The 2.2-_ resolution x-ray crystal structure of the complex of trypsin inhibited by 4-chloro-3-ethoxy-7-guanidinoisocoumarin: a proposed model of the thrombin-inhibitor complex
    J Am Chem Soc112, 7783-7789.  S  I
  227. Schmitt,S., Goetschel,J.D., Rommelt,E.M. and Adler,C.
    One-step purification of trypsin and alpha-chymotrypsin by affinity chromatography on Eupergit-aprotinin, a novel carrier for purification of serine proteases
    J Chromatogr510, 239-242. PubMed  Europe PubMed DOI
    228. 1989
  228. Bartunik,H.D., Summers,L.J. and Bartsch,H.H.
    Crystal structure of bovine beta-trypsin at 1.5 A resolution in a crystal form with low molecular packing density. Active site geometry, ion pairs and solvent structure
    J Mol Biol210, 813-828. PubMed  Europe PubMed  S
  229. Zhou,J.M., Liu,C. and Tsou,C.L.
    Kinetics of trypsin inhibition by its specific inhibitors
    Biochemistry28, 1070-1076. PubMed  Europe PubMed
    230. 1988
  230. Graf,L., Jancso,A., Szilagyi,L., Hegyi,G., Pinter,K., Naray-Szabo,G., Hepp,J., Medzihradszky,K. and Rutter,W.J.
    Electrostatic complementarity within the substrate-binding pocket of trypsin
    Proc Natl Acad Sci U S A85, 4961-4965. PubMed  Europe PubMed
    231. 1987
  231. [YEAR:1-2-1987]Angliker,H., Wikstrom,P., Rauber,P. and Shaw,E.
    The synthesis of lysylfluoromethanes and their properties as inhibitors of trypsin, plasmin and cathepsin B
    Biochem J241, 871-875. PubMed  Europe PubMed  I
  232. Fletcher,T.S., Alhadeff,M., Craik,C.S. and Largman,C.
    Isolation and characterization of a cDNA encoding rat cationic trypsinogen
    Biochemistry26, 3081-3086. PubMed  Europe PubMed
    233. 1984
  233. Bode,W., Walter,J., Huber,R., Wenzel,H.R. and Tschesche,H.
    The refined 2.2-A (0.22-nm) X-ray crystal structure of the ternary complex formed by bovine trypsinogen, valine-valine and the Arg15 analogue of bovine pancreatic trypsin inhibitor
    Eur J Biochem144, 185-190. PubMed  Europe PubMed  S
  234. Craik,C.S., Choo,Q.L., Swift,G.H., Quinto,C., Macdonald,R.J. and Rutter,W.J.
    Structure of two related rat pancreatic trypsin genes
    J Biol Chem259, 14255-14264. PubMed  Europe PubMed
  235. Honey,N.K., Sakaguchi,A.Y., Lalley,P.A., Quinto,C., Macdonald,R.J., Craik,C., Bell,G.I., Rutter,W.J. and Naylor,S.L.
    Chromosomal assignments of genes for trypsin, chymotrypsin B, and elastase in mouse
    Somat Cell Mol Genet10, 377-383. PubMed  Europe PubMed
    236. 1983
  236. Malthouse,J.P.G., Mackenzie,N.E., Boyd,A.S.F. and Scott,A.I.
    Detection of a tetrahedral adduct in a trypsin-chloromethyl ketone specific inhibitor complex by 13C NMR
    J Am Chem Soc105, 1685-1686.  I
  237. Marquart,M., Walter,J., Deisenhofer,J., Bode,W. and Huber,R.
    The geometry of the reactive site and of the peptide groups in trypsin, trypsinogen and its complexes with inhibitors
    Acta Crystallographica Section B-Structural Science39, 480-490. DOI
  238. Walter,J. and Bode,W.
    The X-ray crystal structure analysis of the refined complex formed by bovine trypsin and p-amidinophenylpyruvate at 1.4 A resolution
    Hoppe Seylers Z Physiol Chem364, 949-959. PubMed  Europe PubMed  S
    239. 1982
  239. [YEAR:25-12-1982]Bolognesi,M., Gatti,G., Menagatti,E., Guarneri,M., Marquart,M., Papamokos,E. and Huber,R.
    Three-dimensional structure of the complex between pancreatic secretory trypsin inhibitor (Kazal type) and trypsinogen at 1.8 A resolution. Structure solution, crystallographic refinement and preliminary structural interpretation
    J Mol Biol162, 839-868. PubMed  Europe PubMed  S
  240. [YEAR:25-8-1982]Macdonald,R.J., Stary,S.J. and Swift,G.H.
    Two similar but nonallelic rat pancreatic trypsinogens. Nucleotide sequences of the cloned cDNAs
    J Biol Chem257, 9724-9732. PubMed  Europe PubMed
    241. 1981
  241. [YEAR:27-10-1981]Kossiakoff,A.A. and Spencer,S.A.
    Direct determination of the protonation states of aspartic acid-102 and histidine-57 in the tetrahedral intermediate of the serine proteases: neutron structure of trypsin
    Biochemistry20, 6462-6474. PubMed  Europe PubMed
  242. McRae,B.J., Kurachi,K., Heimark,R.L., Fujikawa,K., Davie,E.W. and Powers,J.C.
    Mapping the active sites of bovine thrombin, factor IXa, factor Xa, factor XIa, factor XIIa, plasma kallikrein, and trypsin with amino acid and peptide thioesters: development of new sensitive substrates
    Biochemistry20, 7196-7206. PubMed  Europe PubMed
    243. 1979
  243. [YEAR:5-2-1979]Bode,W.
    The transition of bovine trypsinogen to a trypsin-like state upon strong ligand binding. II. The binding of the pancreatic trypsin inhibitor and of isoleucine-valine and of sequentially related peptides to trypsinogen and to p-guanidinobenzoate-trypsinogen
    J Mol Biol127, 357-374. PubMed  Europe PubMed  I
    244. 1978
  244. Bloom,J.W. and Hunter,M.J.
    Interactions of alpha1-antitrypsin with trypsin and chymotrypsin
    J Biol Chem253, 547-559. PubMed  Europe PubMed
  245. [YEAR:15-6-1978]Bode,W. and Huber,R.
    Crystal structure analysis and refinement of two variants of trigonal trypsinogen: trigonal trypsin and PEG (polyethylene glycol) trypsinogen and their comparison with orthorhombic trypsin and trigonal trypsinogen
    FEBS Lett90, 265-269. PubMed  Europe PubMed DOI
  246. [YEAR:5-1-1978]Bode,W., Schwager,P. and Huber,R.
    The transition of bovine trypsinogen to a trypsin-like state upon strong ligand binding. The refined crystal structures of the bovine trypsinogen-pancreatic trypsin inhibitor complex and of its ternary complex with Ile-Val at 1.9 A resolution
    J Mol Biol118, 99-112. PubMed  Europe PubMed
  247. DeTraglia,M.C., Brand,J.S. and Tometsko,A.M.
    Characterization of azidobenzamidines as photoaffinity labels for trypsin
    J Biol Chem253, 1846-1852. PubMed  Europe PubMed  I
  248. Huber,R. and Bode,W.
    Structural basis of the activation and action of trypsin
    Acc Chem Res11, 114-122.  S
  249. Lively,M.O. and Powers,J.C.
    Specificity and reactivity of human granulocyte elastase and cathepsin G, porcine pancreatic elastase, bovine chymotrypsin and trypsin toward inhibition with sulfonyl fluorides
    Biochim Biophys Acta525, 171-179. PubMed  Europe PubMed  I
  250. [YEAR:31-10-1978]Porubcan,M.A., Neves,D.E., Rausch,S.K. and Markley,J.L.
    Active site in zymogens. Proton magnetic resonance pH titration curves of histidine-57 in porcine and bovine trypsinogens and in their complexes with bovine pancreatic trypsin inhibitor (Kunitz)
    Biochemistry17, 4640-4647. PubMed  Europe PubMed
    251. 1977
  251. Fehlhammer,H., Bode,W. and Huber,R.
    Crystal structure of bovine trypsinogen at 1-8 A resolution. II. Crystallographic refinement, refined crystal structure and comparison with bovine trypsin
    J Mol Biol111, 415-438. PubMed  Europe PubMed  S
  252. Kossiakoff,A.A., Chambers,J.L., Kay,L.M. and Stroud,R.M.
    Structure of bovine trypsinogen at 1.9 A resolution
    Biochemistry16, 654-664. PubMed  Europe PubMed  S
  253. Kraut,J.
    Serine proteases: structure and mechanism of catalysis
    Annu Rev Biochem46, 331-358. PubMed  Europe PubMed DOI
  254. [YEAR:13-10-1977]Tamura,Y., Hirado,M., Okamura,K., Minato,Y. and Fujii,S.
    Synthetic inhibitors of trypsin, plasmin, kallikrein, thrombin, C1r, and C1 esterase
    Biochim Biophys Acta484, 417-422. PubMed  Europe PubMed  I
    255. 1976
  255. Bode,W., Fehlhammer,H. and Huber,R.
    Crystal structure of bovine trypsinogen at 1-8 A resolution. I. Data collection, application of patterson search techniques and preliminary structural interpretation
    J Mol Biol106, 325-335. PubMed  Europe PubMed  S
  256. Casey,R. and Lang,A.
    Tryptic hydrolysis at asparagine residues in globin chains
    Biochim Biophys Acta434, 184-188. PubMed  Europe PubMed  P
  257. Geratz,J.D., Cheng,M.C. and Tidwell,R.R.
    Novel bis(benzamidino) compounds with an aromatic central link. Inhibitors of thrombin, pancreatic kallikrein, trypsin, and complement
    J Med Chem19, 634-639. PubMed  Europe PubMed  I
    258. 1975
  258. [YEAR:15-11-1975]Bode,W. and Schwager,P.
    The refined crystal structure of bovine beta-trypsin at 1.8 A resolution. II. Crystallographic refinement, calcium binding site, benzamidine binding site and active site at pH 7.0
    J Mol Biol98, 693-717. PubMed  Europe PubMed  S  I
  259. Fehlhammer,H. and Bode,W.
    The refined crystal structure of bovine beta-trypsin at 1.8 A resolution. I. Crystallization, data collection and application of patterson search technique
    J Mol Biol98, 683-692. PubMed  Europe PubMed  S
  260. Geratz,J.D., Mar,E.C., Loeffler,L.J. and Fox,L.B.
    Synthesis of isosteres of p-amidinophenylpyruvic acid. Inhibitors of trypsin, thrombin and pancreatic kallikrein
    J Med Chem18, 287-292. PubMed  Europe PubMed  I
  261. Harpel,P.C. and Cooper,N.R.
    Studies on human plasma C1 inactivator-enzyme interactions. I. Mechanisms of interaction with C1s, plasmin, and trypsin
    J Clin Invest55, 593-604. PubMed  Europe PubMed DOI
  262. [YEAR:30-5-1975]Huber,R., Bode,W., Kukla,D., Kohl,U. and Ryan,C.A.
    The structure of the complex formed by bovine trypsin and bovine pancreatic trypsin inhibitor III. Structure of the anhydro-trypsin-inhibitor complex
    Biophys Struct Mech1, 189-201. PubMed  Europe PubMed  S
  263. [YEAR:8-4-1975]Titani,K., Ericsson,L.H., Neurath,H. and Walsh,K.A.
    Amino acid sequence of dogfish trypsin
    Biochemistry14, 1358-1366. PubMed  Europe PubMed
    264. 1974
  264. [YEAR:15-10-1974]Huber,R., Kukla,D., Bode,W., Schwager,P., Bartels,K., Deisenhofer,J. and Steigemann,W.
    Structure of the complex formed by bovine trypsin and bovine pancreatic trypsin inhibitor. II. Crystallographic refinement at 1.9 A resolution
    J Mol Biol89, 73-101. PubMed  Europe PubMed  S
  265. [YEAR:25-2-1974]Krieger,M., Kay,L.M. and Stroud,R.M.
    Structure and specific binding of trypsin: comparison of inhibited derivatives and a model for substrate binding
    J Mol Biol83, 209-230. PubMed  Europe PubMed  I
  266. [YEAR:24-9-1974]Sweet,R.M., Wright,H.T., Janin,J., Chothia,C.H. and Blow,D.M.
    Crystal structure of the complex of porcine trypsin with soybean trypsin inhibitor (Kunitz) at 2.6-A resolution
    Biochemistry13, 4212-4228. PubMed  Europe PubMed  S
    267. 1973
  267. Baratti,J., Maroux,S. and Louvard,D.
    Effect of ionic strength and calcium ions on the activation of trypsinogen by enterokinase. A modified test for the quantitative evaluation of this enzyme
    Biochim Biophys Acta321, 632-638. PubMed  Europe PubMed
  268. Coats,E.A.
    Comparative inhibition of thrombin, plasmin, trypsin, and complement by benzamidines using substituent constants and regression analysis
    J Med Chem16, 1102-1106. PubMed  Europe PubMed  I
  269. Jameson,G.W., Roberts,D.V., Adams,R.W., Kyle,W.S. and Elmore,D.T.
    Determination of the operational molarity of solutions of bovine alpha-chymotrypsin, trypsin, thrombin and factor Xa by spectrofluorimetric titration
    Biochem J131, 107-117. PubMed  Europe PubMed  I
  270. [YEAR:10-3-1973]Luthy,J.A., Praissman,M., Finkenstadt,W.R. and Laskowski,M., Jr.
    Detailed mechanism of interaction of bovine beta-trypsin with soybean trypsin inhibitor (Kunitz). I. Stopped flow measurements
    J Biol Chem248, 1760-1771. PubMed  Europe PubMed
  271. Ohlsson,K. and Tegner,H.
    Anionic and cationic dog trypsin. Isolation and partial characterization
    Biochim Biophys Acta317, 328-337. PubMed  Europe PubMed
  272. Rinderknecht,H. and Geokas,M.C.
    Anionic and cationic trypsinogens (trypsins) in mammalian pancreas
    Enzyme14, 116-130.
  273. Ruhlmann,A., Kukla,D., Schwager,P., Bartels,K. and Huber,R.
    Structure of the complex formed by bovine trypsin and bovine pancreatic trypsin inhibitor. Crystal structure determination and stereochemistry of the contact region
    J Mol Biol77, 417-436. PubMed  Europe PubMed  S
    274. 1972
  274. [YEAR:28-6-1972]Ako,H., Foster,R.J. and Ryan,C.A.
    The preparation of anhydro-trypsin and its reactivity with naturally occurring proteinase inhibitors
    Biochem Biophys Res Commun47, 1402-1407. PubMed  Europe PubMed
  275. Geratz,J.D.
    Kinetic aspects of the irreversible inhibition of trypsin and related enzymes by p-[m(m-fluorosulfonylphenylureido)phenoxyethoxy]benzamidine
    FEBS Lett20, 294-296. PubMed  Europe PubMed  I
    276. 1971
  276. Keil-Dlouha V,V., Zylber,N., Imhoff,J., Tong,N. and Keil,B.
    Proteolytic activity of pseudotrypsin
    FEBS Lett16, 291-295. PubMed  Europe PubMed
  277. Keil,B.
    8. Trypsin
    Enzymes3, 249-275. DOI
  278. [YEAR:25-11-1971]Kemmler,W., Peterson,J.D. and Steiner,D.F.
    Studies on the conversion of proinsulin to insulin. I. Conversion in vitro with trypsin and carboxypeptidase B
    J Biol Chem246, 6786-6791. PubMed  Europe PubMed
    279. 1970
  279. Feinstein,G.
    Purification of trypsin by affinity chromatography on ovomucoid-Sepharose resin
    FEBS Lett7, 353-355. PubMed  Europe PubMed
  280. Walsh,K.A.
    Trypsinogens and trypsins of various species
    Methods Enzymol19, 41-63. DOI  V
  281. Zahnley,J.C. and Davis,J.G.
    Determination of trypsin-inhibitor complex dissociation by use of the active site titrant, p-nitrophenyl p'-guanidinobenzoate
    Biochemistry9, 1428-1433. PubMed  Europe PubMed  I
    282. 1969
  282. Abita,J.P., Delaage,M. and Lazdunski,M.
    The mechanism of activation of trypsinogen. The role of the four N-terminal aspartyl residues
    Eur J Biochem8, 314-324. PubMed  Europe PubMed
  283. Chase,T., Jr. and Shaw,E.
    Comparison of the esterase activities of trypsin, plasmin, and thrombin on guanidinobenzoate esters. Titration of the enzymes
    Biochemistry8, 2212-2224. PubMed  Europe PubMed DOI  I
  284. Smith,R.L. and Shaw,E.
    Pseudotrypsin. A modified bovine trypsin produced by limited autodigestion
    J Biol Chem244, 4704-4712. PubMed  Europe PubMed  I
    285. 1968
  285. Baker,B.R. and Erickson,E.H.
    Irreversible enzyme inhibitors. CXV. Proteolytic enzymes. V. Active-site-directed irreversible inhibitors of trypsin derived from p-(phenoxyalkoxy) benzamidines with a terminal sulfonyl fluoride
    J Med Chem11, 245-249. PubMed  Europe PubMed  I
  286. Elmore,D.T. and Smyth,J.J.
    A new method for determining the absolute molarity of solutions of trypsin and chymotrypsin by using p-nitrophenyl N2-acetyl-N1-benzylcarbazate
    Biochem J107, 103-107. PubMed  Europe PubMed  I
  287. Elmore,D.T. and Smyth,J.J.
    The behaviour of trypsin towards alpha-N-methyl-alpha-N-toluene-p-sulfonyl-L-lysine beta-naphthyl ester. A new method for determining the absolute molarity of solutions of trypsin
    Biochem J107, 97-102. PubMed  Europe PubMed  A
  288. Tanizawa,K., Ishii,S.I. and Kanaoka,Y.
    Trypsin substrates derived from benzamidine: application to active site titration and isolation of acyl-enzyme intermediate
    Biochem Biophys Res Commun32, 893-897. PubMed  Europe PubMed  I
    289. 1967
  289. [YEAR:30-11-1967]Chase,T., Jr. and Shaw,E.
    p-Nitrophenyl-p'-guanidinobenzoate HCl: a new active site titrant for trypsin
    Biochem Biophys Res Commun29, 508-514. PubMed  Europe PubMed  I
  290. Elmore,D.T., Roberts,D.V. and Smyth,J.J.
    Kinetics and mechanism of catalysis by proteolytic enzymes: the kinetics of hydrolysis of derivatives of l-lysine and S-(beta-aminoethyl)-l-cysteine(thialysine)by bovine trypsin
    Biochem J102, 728-734. PubMed  Europe PubMed
  291. Rovery,M.
    [25] Chromatography of trypsin to remove chymotrypsin, and of chymotrypsin to remove trypsin
    Methods Enzymol11, 231-236. DOI
    292. 1966
  292. Bender,M.L., Begue-Canton,M.L., Blakeley,R.L., Brubacher,L.J., Feder,J., Gunter,C.R., Kezdy,F.J., Killheffer,J.V., Jr., Marshall,T.H., Miller,C.G., Roeske,R.W. and Stoops,J.K.
    The determination of the concentration of hydrolytic enzyme solutions: alpha-chymotrypsin, trypsin, papain, elastase, subtilisin, and acetylcholinesterase
    J Am Chem Soc88, 5890-5913. PubMed  Europe PubMed
  293. [YEAR:25-11-1966]Feinstein,G. and Feeney,R.E.
    Interaction of inactive derivatives of chymotrypsin and trypsin with protein inhibitors
    J Biol Chem241, 5183-5189. PubMed  Europe PubMed
    294. 1965
  294. Hartley,B.S., Brown,J.R., Kauffman,D.L. and Smillie,L.B.
    Evolutionary similarities between pancreatic proteolytic enzymes
    Nature207, 1157-1159. PubMed  Europe PubMed DOI
  295. Mares-Guia,M. and Shaw,E.
    Studies on the active center of trypsin. The binding of amidines and guanidines as models of the substrate side chain
    J Biol Chem240, 1579-1585. PubMed  Europe PubMed  I
  296. Plapinger,R.E., Nachlas,M.M., Seligman,M.L. and Seligman,A.M.
    Synthesis of chromogenic arginine derivatives as substrates for trypsin
    J Org Chem30, 1781-1785. PubMed  Europe PubMed
  297. Shaw,E., Mares-Guia,M. and Cohen,W.
    Evidence for an active-center histidine in trypsin through use of a specific reagent, 1-chloro-3-tosylamido-7-amino-2-heptanone, the chloromethyl ketone derived from Nalpha-tosyl-L-lysine
    Biochemistry4, 2219-2224.  I
    298. 1964
  298. Walsh,K.A., Kauffman,D.L., Kumar,K.S. and Neurath,H.
    ON THE STRUCTURE AND FUNCTION OF BOVINE TRYPSINOGEN AND TRYPSIN
    Proc Natl Acad Sci U S A51, 301-308. PubMed  Europe PubMed
  299. Walsh,K.A. and Neurath,H.
    Trypsinogen and chymotrypsinogen as homologous proteins
    Proc Natl Acad Sci U S A52, 884-889. PubMed  Europe PubMed
    300. 1963
  300. Fahrney,D.E. and Gold,A.M.
    Sulfonyl fluorides as inhibitors of esterases. I. Rates of reaction with acetylcholinesterase, alpha-chymotrypsin, and trypsin
    J Am Chem Soc85, 997-1000. DOI  I
  301. Inagami,T. and Murachi,T.
    Induced activation of the catalytic site of trypsin
    J Biol Chem238, C1905-C1907. PubMed  Europe PubMed
  302. Roth,M.
    [Fluorimetric determination of trypsin]
    Clin Chim Acta8, 574-578. PubMed  Europe PubMed  A
  303. Trowbridge,C.G., Krehbiel,A. and Laskowski,M., Jr.
    Substrate activation of trypsin
    Biochemistry2, 843-850. PubMed  Europe PubMed
  304. Wolf,J.P., III and Niemann,C.
    The alpha-chymotrypsin-catalyzed hydrolysis of a series of analogs of acetylglycine methyl ester
    Biochemistry2, 493-497. PubMed  Europe PubMed
    305. 1962
  305. Allende,J.E. and Richards,F.M.
    The action of trypsin on ribonuclease-S
    Biochemistry1, 295-304. PubMed  Europe PubMed
  306. Travis,J. and Liener,I.E.
    The crystallization of pork trypsin
    Arch Biochem Biophys97, 218-219. PubMed  Europe PubMed
  307. [YEAR:17-12-1962]Walsh,K.A., Kauffman,D.L. and Neurath,H.
    Peptides isolated from tryptic and chymotryptic hydrolysates of S-sulfotrypsinogen
    Biochim Biophys Acta65, 540-543. PubMed  Europe PubMed
    308. 1959
  308. Greenbaum,L.M., Hirshkowitz,A. and Shoichet,I.
    The activation of trypsinogen by cathepsin B
    J Biol Chem234, 2885-2890. PubMed  Europe PubMed
  309. Hummel,B.C.
    A modified spectrophotometric determination of chymotrypsin, trypsin, and thrombin
    Can J Biochem Physiol37, 1393-1399. PubMed  Europe PubMed  A
  310. Riedel,A., Wunsch,E. and Hartl,A.
    Nalpha-Benzoyl-arginin-á-naphthylamid als Substrat zur quantitaven kolorimetrischen Bestimmung von Trypsin
    Hoppe Seylers Z Physiol Chem316, 61-70.  A
    311. 1958
  311. Dixon,G.H., Kauffman,D.L. and Neurath,H.
    Amino acid sequence in the region of di-isopropyl phosphoryl binding in dip-trypsin
    J Am Chem Soc80, 1260-1261.  I
  312. Dixon,G.H., Kauffman,D.L. and Neurath,H.
    Amino acid sequence in the region of diisopropylphosphoryl binding in diisopropylphosphoryl-trypsin
    J Biol Chem233, 1373-1381. PubMed  Europe PubMed  I
    313. 1957
  313. Green,N.M.
    Kinetics of the reaction between trypsin and the pancreatic trypsin inhibitor
    Biochem J66, 407-415. PubMed  Europe PubMed
    314. 1956
  314. Dixon,G.H. and Neurath,H.
    The reaction of DFP with trypsin
    Biochim Biophys Acta20, 572-574. PubMed  Europe PubMed  I
  315. Watson,J.
    Trypsin-catalyzed reactions of lysyl-lysine ethyl ester
    Institute of Physics Online Archive52, 592-605.
    316. 1955
  316. Davie,E.W. and Neurath,H.
    Identification of a peptide released during autocatalytic activation of trypsinogen
    J Biol Chem212, 515-529. PubMed  Europe PubMed
  317. Laskowski,M.
    [3] Trypsinogen and trypsin
    Methods Enzymol2, 26-36. DOI  V
  318. Schwert,G.W. and Takenaka,Y.
    A spectrophotometric determination of trypsin and chymotrypsin
    Biochim Biophys Acta16, 570-575. PubMed  Europe PubMed  A
    319. 1954
  319. Ram,J.S., Terminiello,L., Bier,M. and Nord,F.F.
    On the mechanism of enzyme action. LVII. Interaction between trypsin and ovomucoid
    Arch Biochem52, 451-463. PubMed  Europe PubMed
    320. 1953
  320. Green,N.M. and Work,E.
    Pancreatic trypsin inhibitor. II. Reaction with trypsin
    Biochem J54, 347-352. PubMed  Europe PubMed
  321. Green,N.M. and Neurath,H.
    The effects of divalent cations on trypsin
    J Biol Chem204, 379-390. PubMed  Europe PubMed
    322. 1951
  322. Sanger,F. and Tuppy,H.
    Amino-acid sequence in the phenylalanyl chain of insulin. 2. The investigation of peptides from enzymic hydrolysates
    Biochem J49, 481-490. PubMed  Europe PubMed  P
    323. 1950
  323. Neurath,H. and Schwert,G.W.
    The mode of action of the crystalline pancreatic proteolytic enzymes
    Chem Rev46, 69-153. PubMed  Europe PubMed  V
    324. 1948
  324. Schwert,G.W. and Neurath,H.
    The specific esterase activity of trypsin
    J Biol Chem172, 221-239. PubMed  Europe PubMed
    325. 1947
  325. [YEAR:20-3-1947]Kunitz,M.
    Isolation of a crystalline protein compound of trypsin and of soybean trypsin-inhibitor
    J Gen Physiol30, 311-320. PubMed  Europe PubMed DOI
    326. 1946
  326. McDonald,M.R. and Kunitz,M.
    An improved method for the crystallization of trypsin
    J Gen Physiol29, 155-156. PubMed  Europe PubMed DOI
    327. 1941
  327. Butler,J.A.V.
    The molecular kinetics of trypsin action
    J Am Chem Soc63, 2971-2974.
  328. [YEAR:20-9-1941]McDonald,M.R. and Kunitz,M.
    The effect of calcium and other ions on the autocatalytic formation of trypsin from trypsinogen
    J Gen Physiol25, 53-73. PubMed  Europe PubMed DOI
    329. 1939
  329. Hofmann,K. and Bergmann,M.
    The specificity of trypsin. II
    J Biol Chem130, 81-86.
  330. [YEAR:20-3-1939]Kunitz,M.
    Formation of trypsin from crystalline trypsinogen by means of enterokinase
    J Gen Physiol22, 429-446. PubMed  Europe PubMed DOI
  331. [YEAR:20-9-1938]Anson,M.L.
    The estimation of pepsin, trypsin, papain and cathepsin with hemoglobin
    J Gen Physiol22, 79-89. PubMed  Europe PubMed DOI  A
    332. 1938
  332. [YEAR:20-5-1938]Kunitz,M.
    Formation of trypsin from trypsinogen by an enzyme produced by a mold of the genus Penicillium
    J Gen Physiol21, 601-620. PubMed  Europe PubMed DOI
    333. 1936
  333. Kunitz,M. and Northrop,J.H.
    Isolation from beef pancreas of crystalline trypsinogen, trypsin, a trypsin inhibitor, and an inhibitor-trypsin compound
    J Gen Physiol19, 991-1007. PubMed  Europe PubMed DOI
    334. 1935
  334. Bergmann,M., Zervas,L. and Fruton,J.S.
    A synthetic peptide as substrate for tryptic proteinase
    Science81, 180-180. PubMed  Europe PubMed DOI
    335. 1934
  335. [YEAR:20-3-1934]Kunitz,M. and Northrop,J.H.
    Inactivation of crystalline trypsin
    J Gen Physiol17, 591-615. PubMed  Europe PubMed DOI
    336. 1932
  336. [YEAR:20-11-1932]Northrop,J.H.
    Crystalline trypsin: V. Kinetics of the digestion of proteins with crude and crystalline trypsin
    J Gen Physiol16, 339-348. PubMed  Europe PubMed DOI
  337. [YEAR:20-11-1932]Northrop,J.H. and Kunitz,M.
    Crystalline trypsin: II. General properties
    J Gen Physiol16, 295-311. PubMed  Europe PubMed DOI
  338. [YEAR:20-11-1932]Northrop,J.H. and Kunitz,M.
    Crystalline trypsin: III. Experimental procedure and methods of measuring activity
    J Gen Physiol16, 313-321. PubMed  Europe PubMed DOI
  339. [YEAR:20-11-1932]Northrop,J.H.
    Crystalline trypsin: IV. Reversibility of the inactivation and denaturation of trypsin by heat
    J Gen Physiol16, 323-337. PubMed  Europe PubMed DOI
  340. Northrop,J.H. and Kunitz,M.
    Crystalline trypsin. I. Isolation and tests of purity
    J Gen Physiol16, 267-294. PubMed  Europe PubMed DOI
    341. 1925
  341. [YEAR:20-3-1924]Northrop,J.H.
    The kinetics of trypsin digestion: II. Conditions under which the reaction is monomolecular
    J Gen Physiol6, 417-428. PubMed  Europe PubMed DOI
  342. [YEAR:20-3-1924]Northrop,J.H.
    The kinetics of trypsin digestion: III. The course of the reaction with constant substrate under conditions causing inactivation of the enzyme
    J Gen Physiol6, 429-437. PubMed  Europe PubMed DOI
  343. [YEAR:20-3-1924]Northrop,J.H.
    The kinetics of trypsin digestion: IV. The course of the reaction when both substrate and enzyme concentrations are decreasing
    J Gen Physiol6, 439-452. PubMed  Europe PubMed DOI
  344. [YEAR:20-1-1924]Northrop,J.H.
    The kinetics of trypsin digestion: I. Experimental evidence concerning the existence of an intermediate compound
    J Gen Physiol6, 239-243. PubMed  Europe PubMed DOI
  345. [YEAR:20-7-1924]Northrop,J.H.
    The kinetics of trypsin digestion: V. Schutz's rule
    J Gen Physiol6, 723-729. PubMed  Europe PubMed DOI
  346. [YEAR:20-1-1924]Northrop,J.H.
    A test for diffusible ions: I. The ionic nature of trypsin
    J Gen Physiol6, 337-347. PubMed  Europe PubMed DOI
    347. 1923
  347. [YEAR:20-1-1923]Northrop,J.H. and Hussey,R.G.
    A method for the quantitative determination of trypsin and pepsin
    J Gen Physiol5, 353-358. PubMed  Europe PubMed DOI
  348. [YEAR:20-5-1922]Northrop,J.H.
    Does the kinetics of trypsin digestion depend on the formation of a compound between enzyme and substrate
    J Gen Physiol4, 487-509. PubMed  Europe PubMed DOI
    349. 1911
  349. White,G.F. and Crozier,W.
    Comparative proteolysis experiments with trypsin
    J Am Chem Soc30, 2042-2048.
    350. 1905
  350. Hedin,S.G.
    Observations on the action of trypsin
    J Physiol32, 468-485. PubMed  Europe PubMed DOI

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