Literature for peptidase S01.151: trypsin 1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, M Mutation, P Specificity, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

2026

Han,M., Cha,J. and Lee,S.H. Ultrasensitive Fluorescent Detection of Urinary Trypsin for Early Pancreatic Disease Diagnosis: Toward Smartphone-Assisted Analysis Chem Asian J (2026) 21, e70557-e70557. PubMed Europe PubMed DOI

2025

Campuzano-Gonzalez,A., Gil-Rodriguez,P., Quintana-Armas,A.X., Guerra,Y., Perez,Y. and Rudino-Pinera,E. Structural determination of a new non-canonical inhibition complex between porcine trypsin and M271 a potato Kunitz-STI inhibitor Biochem Biophys Res Commun (2025) 768, 151818-151818. PubMed Europe PubMed DOI
Chen,J., Jiang,G. and Tian,Y. Advances in trypsin research: sources, structural insights, applications and protein engineering for industrial use Int J Biol Macromol (2025) 334, 148996-148996. PubMed Europe PubMed DOI
Garge,S.Y., Suvarna,V., Sonavane,S.V. and Singh,P.K. A Dual-Detection AIE-Based Fluorescent Probe for Sensitive Detection of Protamine and Trypsin in Biological Media ACS Appl Bio Mater (2025) PubMed Europe PubMed DOI
Geisz-Fremy,A. Pathologically relevant trypsinogen activation in pancreatitis Am J Physiol Gastrointest Liver Physiol (2025) PubMed Europe PubMed DOI
Inci Ozbagci,D., Ilkar Erdagi,S. and Aydin,R. Plant-based phenolic acids: exploring the interaction of digestive enzyme trypsin/DNA and antioxidant potential J Biomol Struct Dyn (2025) , 1-20. PubMed Europe PubMed DOI
Lai,J., Wang,D., Sheng,X., Ding,C.F. and Yan,Y. A DNA tetrahedron-inspired magnetic hybrid with regular distribution of trypsin for ultra-fast digestion of proteins and glycoproteomics analysis Analyst (2025) PubMed Europe PubMed DOI
Lim,J., Seong,H. and Lee,S.H. A highly sensitive fluorogenic assay for trypsin in urine: a simple diagnostic approach for pancreatic diseases Org Biomol Chem (2025) PubMed Europe PubMed DOI
Liu,H., Yin,W., Zong,W., Wang,Y. and Lan,J. Nanoplastics Intensify the Inhibitory Effect of Di-n-octylo-phthalate on Trypsin: Spectroscopic and Computer Simulation Analysis Chem Biodivers (2025) , e00316-e00316. PubMed Europe PubMed DOI
Lv,J., Xu,J., Chen,Y., Tang,W., Xu,W., Wang,M., Zhang,X., Zhu,Z., Chen,S., Hu,Q. and Niu,L. Amplification by Polysaccharides for the Electrochemical Detection of Trypsin Activity Anal Chem (2025) 97, 20549-20556. PubMed Europe PubMed DOI
Modenbach,J.M., Moller,C., Asgarbeik,S., Geist,N., Rimkus,N., Dorr,M., Wolfgramm,H., Steil,L., Susemihl,A., Graf,L., Schmoker,O., Bottcher,D., Hammer,E., Glaubitz,J., Lammers,M., Delcea,M., Volker,U., Aghdassi,A.A., Lerch,M.M., Weiss,F.U., Bornscheuer,U.T. and Sendler,M. Biochemical analyses of cystatin-C dimers and cathepsin-B reveals a trypsin-driven feedback mechanism in acute pancreatitis Nat Commun (2025) 16, 1702-1702. PubMed Europe PubMed DOI PMC EPMC
Ozbagci,D.I. Interaction of two key biological targets -trypsin and DNA- with phenolic Phytochemicals: Insights from molecular docking and radical scavenging potential Arch Biochem Biophys (2025) 772, 110567-110567. PubMed Europe PubMed DOI
Xiao,W., Li,Z., Chen,C., Shi,Y., Fang,P., Xiao,S. and Fang,L. Revisiting the roles of trypsin in the productive infection of porcine deltacoronavirus in porcine-derived cells Virology (2025) 604, 110453-110453. PubMed Europe PubMed DOI
Zhang,W., Tan,M., Chen,M., Chen,W. and Li,M.J. Dual-functional AIE-active Ir(III) complexes for trypsin detection and organelle-targeted photodynamic therapy J Inorg Biochem (2025) 275, 113148-113148. PubMed Europe PubMed DOI
Zhang,W., Qi,X., Mi,Z., Wang,H., Lv,S., Song,Y., Su,P., Song,J. and Yang,Y. A New Phosphorylated Protein Analysis Strategy based on Trypsin Encapsulated in Metal-Organic Frameworks with High Efficiency and a Simplified Workflow Anal Chem (2025) PubMed Europe PubMed DOI

2024

Ahmad,M.S., Kalam,N., Akbar,Z., Shah,N., Rasheed,S. and Choudhary,M.I. Structural basis for the binding of famotidine, cimetidine, guanidine, and pimagedine with serine protease Biochem Biophys Res Commun (2024) 733, 150603-150603. PubMed Europe PubMed DOI
Al-Shabib,N.A., Khan,J.M., Malik,A., Alamri,A., Rehman,M.T., Alajmi,M.F. and Husain,F.M. Probing the interaction mechanisms between sunset yellow dye and trypsin protein leading to amorphous aggregation under low pH conditions Int J Biol Macromol (2024) 265, 130442-130442. PubMed Europe PubMed DOI
Allemann,A., Staubli,S.M. and Nebiker,C.A. Trypsin and Trypsinogen Activation Peptide in the Prediction of Severity of Acute Pancreatitis Life (Basel) (2024) 14 PubMed Europe PubMed DOI PMC EPMC V
Behshad,Y., Pazhang,M., Najavand,S. and Sabzi,M. Enhancing Enzyme Stability and Functionality: Covalent Immobilization of Trypsin on Magnetic Gum Arabic Modified Fe(3)O(4) Nanoparticles Appl Biochem Biotechnol (2024) 196, 5283-5300. PubMed Europe PubMed DOI
Cai,H., Yuan,R., Huang,S., Huang,Y., Lin,C., Lin,Y., Luo,F., Lin,Z. and Wang,L. Sensitive trypsin sensor based on the regulation of microscale ionic current rectification by the selectivity hydrolysis of hydrogel filled in microchannel Talanta (2024) 285, 127422-127422. PubMed Europe PubMed DOI
Crosby,H.A., Keim,K., Kwiecinski,J.M., Langouet-Astrie,C.J., Oshima,K., LaRiviere,W.B., Schmidt,E.P. and Horswill,A.R. Host-derived protease promotes aggregation of Staphylococcus aureus by cleaving the surface protein SasG MBio (2024) 15, e0348323-e0348323. PubMed Europe PubMed DOI PMC EPMC
Ofori,S., Desai,H.S., Shikwana,F., Boatner,L.M., Dominguez Iii,E.R., Castellon,J.O. and Backus,K.M. Generating cysteine-trypsin cleavage sites with 2-chloroacetamidine capping Chem Commun (Camb) (2024) 60, 8856-8859. PubMed Europe PubMed DOI
Patel,C.K. and Mukherjee,T.K. Biomolecular Condensation of Trypsin Prevents Autolysis and Promotes Ca(2+)-Mediated Activation of Esterase Activity Biomacromolecules (2024) 25, 6082-6092. PubMed Europe PubMed DOI
Song,H., Choi,H., Kim,Y.S. and Lee,S.H. Micelle-based fluorogenic sensing of trypsin: a sensitive method in pancreatic disease diagnosis Org Biomol Chem (2024) 22, 4243-4248. PubMed Europe PubMed DOI
Wang,J., Kong,J. and Zhang,X. Riboflavin-induced photo-ATRP electrochemical strategy for detection of biomarker trypsin Talanta (2024) 277, 126386-126386. PubMed Europe PubMed DOI
Xiang,Y., Jiang,Y. and Lu,L. Low-Dose Trypsin Accelerates Wound Healing via Protease-Activated Receptor 2 ACS Pharmacol Transl Sci (2024) 7, 274-284. PubMed Europe PubMed DOI PMC EPMC
Zierke,L., John,D., Gischke,M., Tran,Q.T., Sendler,M., Weiss,F.U., Bornscheuer,U.T., Ritter,C., Lerch,M.M. and Aghdassi,A.A. Initiation of acute pancreatitis in mice is independent of fusion between lysosomes and zymogen granules Cell Mol Life Sci (2024) 81, 207-207. PubMed Europe PubMed DOI PMC EPMC

2023

Arora,A., Sharma,K. and Tripathi,S.K. Impact of luminescent MoSe(2) quantum dots on activity of trypsin under different pH environment Spectrochim Acta A Mol Biomol Spectrosc (2023) 302, 122958-122958. PubMed Europe PubMed DOI
Bianchimano,P., Iwanowski,K., Smith,E.M., Cantor,A., Leone,P., Bongers,G., Gonzalez,C.G., Hongsup,Y., Elias,J., Weiner,H.L., Clemente,J.C. and Tankou,S.K. Oral vancomycin treatment suppresses gut trypsin activity and preserves intestinal barrier function during EAE iScience (2023) 26, 108143-108143. PubMed Europe PubMed DOI PMC EPMC
Chen,J., Xu,F. and Wang,Y. Biomass-derived magnetic nanocomposites modified by choline chloride/citric acid based natural deep eutectic solvents for the magnetic solid phase extraction of trypsin Analyst (2023) 148, 2316-2326. PubMed Europe PubMed DOI
Kellnerova,S., Huber,S., Massri,M., Fleischer,V., Losso,K., Sarg,B., Kremser,L., Talasz,H., He,X., Varrone,E., Brigotti,M., Ardissino,G., Orth-Holler,D. and Wurzner,R. Enzymatic Cleavage of Stx2a in the Gut and Identification of Pancreatic Elastase and Trypsin as Possible Main Cleavers Microorganisms (2023) 11 PubMed Europe PubMed DOI PMC EPMC
Liu,X., Huang,Q., Pan,P., Fang,M., Zhang,Y., Yang,S., Li,M. and Liu,Y. Comparative Study of the Preparation of High-Molecular-Weight Fibroin by Degumming Silk with Several Neutral Proteases Polymers (Basel) (2023) 15 PubMed Europe PubMed DOI PMC EPMC
Saroha,B., Kumar,G., Arya,P., Raghav,N. and Kumar,S. Some morpholine tethered novel aurones: Design, synthesis, biological, kinetic and molecular docking studies Bioorg Chem (2023) 140, 106805-106805. PubMed Europe PubMed DOI
Solovyev,M., Kashinskaya,E. and Gisbert,E. A meta-analysis for assessing the contributions of trypsin and chymotrypsin as the two major endoproteases in protein hydrolysis in fish intestine Comp Biochem Physiol A Mol Integr Physiol (2023) 278, 111372-111372. PubMed Europe PubMed DOI
Sun,Z., Xiao,W., Li,N., Chang,L., Xu,P. and Li,Y. Large-Scale Profiling of Unexpected Tryptic Cleaved Sites at Ubiquitinated Lysines J Proteome Res (2023) 22, 1245-1254. PubMed Europe PubMed DOI
Vosahlova-Kadlecova,Z., Gilar,M., Molnarova,K., Kozlik,P. and Kalikova,K. Mixed-mode column allows simple direct coupling with immobilized enzymatic reactor for on-line protein digestion J Chromatogr B Analyt Technol Biomed Life Sci (2023) 1228, 123866-123866. PubMed Europe PubMed DOI
Woessmann,J., Petrosius,V., Uresin,N., Kotol,D., Aragon-Fernandez,P., Hober,A., auf dem Keller,U., Edfors,F. and Schoof,E.M. Assessing the Role of Trypsin in Quantitative Plasma and Single-Cell Proteomics toward Clinical Application Anal Chem (2023) 95, 13649-13658. PubMed Europe PubMed DOI PMC EPMC
Wu,N.N., Chen,L.G., Xiao,M.Z., Yuan,R.Y. and Wang,H.B. Determination of trypsin using protamine mediated fluorescent enhancement of DNA templated Au nanoclusters Mikrochim Acta (2023) 190, 158-158. PubMed Europe PubMed DOI

2022

Ai,Y., Xu,J., Gunawardena,H.P., Zare,R.N. and Chen,H. Investigation of Tryptic Protein Digestion in Microdroplets and in Bulk Solution J Am Soc Mass Spectrom (2022) 33, 1238-1249. PubMed Europe PubMed DOI
Ansari,N., Rizzi,V. and Parrinello,M. Water regulates the residence time of Benzamidine in Trypsin Nat Commun (2022) 13, 5438-5438. PubMed Europe PubMed DOI PMC EPMC I
Arnaiz,A., Guembe-Garcia,M., Delgado-Pinar,E., Valente,A.J.M., Ibeas,S., Garcia,J.M. and Vallejos,S. The role of polymeric chains as a protective environment for improving the stability and efficiency of fluorogenic peptide substrates Sci Rep (2022) 12, 8818-8818. PubMed Europe PubMed DOI PMC EPMC
Li,H., Gao,Z. and Zhang,S. Localization of trypsin, chymotrypsin and elastase in the digestive tract of amphioxus Branchiostoma japonicum with implications to the origin of vertebrate pancreas Tissue Cell (2022) 79, 101943-101943. PubMed Europe PubMed DOI
Li,Y., Watanabe,E., Kawashima,Y., Plichta,D.R., Wang,Z., Ujike,M., Ang,Q.Y., Wu,R., Furuichi,M., Takeshita,K., Yoshida,K., Nishiyama,K., Kearney,S.M., Suda,W., Hattori,M., Sasajima,S., Matsunaga,T., Zhang,X., Watanabe,K., Fujishiro,J., Norman,J.M., Olle,B., Matsuyama,S., Namkoong,H., Uwamino,Y., Ishii,M., Fukunaga,K., Hasegawa,N., Ohara,O., Xavier,R.J., Atarashi,K. and Honda,K. Identification of trypsin-degrading commensals in the large intestine Nature (2022) 609, 582-589. PubMed Europe PubMed DOI PMC EPMC
Park,S., Lee,H. and Yang,H. Sensitive Affinity-Based Biosensor Using the Autocatalytic Activation of Trypsinogen Mutant by Trypsin with Low Self-activation ACS Appl Bio Mater (2022) PubMed Europe PubMed DOI

2021

Fu,Z., Akula,S., Thorpe,M. and Hellman,L. Marked difference in efficiency of the digestive enzymes pepsin, trypsin, chymotrypsin, and pancreatic elastase to cleave tightly folded proteins Biol Chem (2021) 402, 861-867. PubMed Europe PubMed DOI
Mahmoud,G.S., Hosny,G. and Sayed,S.A. Hepatoprotective effect of trypsin/chymotrypsin against olanzapine-induced non-alcoholic steatohepatitis in rats Can J Physiol Pharmacol (2021) , 1-9. PubMed Europe PubMed DOI
More,K.N., Lim,T.H., Kang,J. and Chang,D.J. A Fluorogenic Assay: Analysis of Chemical Modification of Lysine and Arginine to Control Proteolytic Activity of Trypsin Molecules (2021) 26 PubMed Europe PubMed DOI PMC EPMC
Pandeswari,P.B., Chary,R.N., Kamalanathan,A.S., Prabhakar,S. and Sabareesh,V. Mimicking LysC Proteolysis by 'Arginine-Modification-cum-Trypsin digestion': Comparison of Bottom-Up & Middle-Down Proteomic Approaches by ESI-QTOF-MS Protein Pept Lett (2021) PubMed Europe PubMed DOI
Rivera Del Rio,A., Keppler,J.K., Boom,R.M. and Janssen,A.E.M. Protein acidification and hydrolysis by pepsin ensure efficient trypsin-catalyzed hydrolysis Food Funct (2021) 12, 4570-4581. PubMed Europe PubMed DOI
Taraskin,A.S., Semenov,K.K., Protasov,A.V., Lozhkov,A.A., Tyulin,A.A., Shaldzhyan,A.A., Ramsay,E.S., Mirgorodskaya,O.A., Klotchenko,S.A. and Zabrodskaya,Y.A. Quench me if you can: Alpha-2-macroglobulin trypsin complexes enable serum biomarker analysis by MALDI mass spectrometry Biochimie (2021) 185, 87-95. PubMed Europe PubMed DOI
Yuan,N., Jia,L. and Zhu,J. Label-free Fluorescence Turn on Trypsin Assay Based on Gemini Surfactant/heparin/Nile Red Supramolecular Assembly J Fluoresc (2021) 31, 1537-1545. PubMed Europe PubMed DOI

2020

Ahmed Al-Hadhrami,N., Ladwig,A., Rahman,A., Rozas,I., Paul,G.M. and Evans,P. Synthesis of 2-guanidinyl pyridines and their trypsin inhibition and docking Bioorg Med Chem (2020) 28, 115612-115612. PubMed Europe PubMed DOI
Bubis,J.A., Gorshkov,V., Gorshkov,M.V. and Kjeldsen,F. PhosphoShield: Improving Trypsin Digestion of Phosphoproteins by Shielding the Negatively Charged Phosphate Moiety J Am Soc Mass Spectrom (2020) PubMed Europe PubMed DOI
Chen,X., Chen,D., Huang,L., Chen,X., Zhou,M., Xi,X., Ma,C., Chen,T. and Wang,L. Identification and Target-Modification of SL-BBI: A Novel Bowman-Birk Type Trypsin Inhibitor from Sylvirana latouchii Biomolecules (2020) 10 PubMed Europe PubMed DOI
Dau,T., Bartolomucci,G. and Rappsilber,J. Proteomics Using Protease Alternatives to Trypsin Benefits from Sequential Digestion with Trypsin Anal Chem (2020) 92, 9523-9527. PubMed Europe PubMed DOI PMC EPMC
Duan,X., Li,N., Wang,G. and Su,X. High sensitive ratiometric fluorescence analysis of trypsin and dithiothreitol based on WS2 QDs Talanta (2020) 219, 121171-121171. PubMed Europe PubMed DOI
Estaras,M., Ameur,F.Z., Estevez,M., Diaz-Velasco,S. and Gonzalez,A. The lysine derivative aminoadipic acid, a biomarker of protein oxidation and diabetes-risk, induces production of reactive oxygen species and impairs trypsin secretion in mouse pancreatic acinar cells Food Chem Toxicol (2020) , 111594-111594. PubMed Europe PubMed DOI
Hu,Q., Bao,Y., Gan,S., Zhang,Y., Han,D. and Niu,L. Electrochemically controlled grafting of polymers for ultrasensitive electrochemical assay of trypsin activity Biosens Bioelectron (2020) 165, 112358-112358. PubMed Europe PubMed DOI
Jaimes,J., Millet,J. and Whittaker,G. Proteolytic Cleavage of the SARS-CoV-2 Spike Protein and the Role of the Novel S1/S2 Site SSRN (2020) , 3581359-3581359. PubMed Europe PubMed DOI PMC EPMC
Kahler,U., Kamenik,A.S., Waibl,F., Kraml,J. and Liedl,K.R. Protein-Protein Binding as a Two-Step Mechanism: Preselection of Encounter Poses during the Binding of BPTI and Trypsin Biophys J (2020) 119, 652-666. PubMed Europe PubMed DOI PMC EPMC
Ma,H., Zou,T., Li,H. and Cheng,H. The interaction of sodium dodecyl sulfate with trypsin: Multi-spectroscopic analysis, molecular docking, and molecular dynamics simulation Int J Biol Macromol (2020) PubMed Europe PubMed DOI
Melikishvili,S., Dizon,M. and Hianik,T. Application of high-resolution ultrasonic spectroscopy for real-time monitoring of trypsin activity in beta-casein solution Food Chem (2020) 337, 127759-127759. PubMed Europe PubMed DOI
Millan-Martin,S., Jakes,C., Carillo,S., Buchanan,T., Guender,M., Kristensen,D.B., Sloth,T.M., Orgaard,M., Cook,K. and Bones,J. Inter-laboratory study of an optimised peptide mapping workflow using automated trypsin digestion for monitoring monoclonal antibody product quality attributes Anal Bioanal Chem (2020) PubMed Europe PubMed DOI
Mourao,C.B.F., Brand,G.D., Fernandes,J.P.C., Prates,M.V., Bloch,C., Jr., Barbosa,J.A.R.G., Freitas,S.M., Restano-Cassulini,R., Possani,L.D. and Schwartz,E.F. Head-to-Tail Cyclization after Interaction with Trypsin: A Scorpion Venom Peptide that Resembles Plant Cyclotides J Med Chem (2020) PubMed Europe PubMed DOI
Nanjundaiah,S.N., Ma,J., Sukumaran,S. and Sambasivam,G. Development of clone with novel TrpE fusion tag in E. coli for overexpression of trypsin in a bench-scale bioreactor Prep Biochem Biotechnol (2020) , 1-9. PubMed Europe PubMed DOI
Niu,B., Martinelli Ii,M., Jiao,Y., Wang,C., Cao,M., Wang,J. and Meinke,E. Nonspecific cleavages arising from reconstitution of trypsin under mildly acidic conditions PLoS ONE (2020) 15, e0236740-e0236740. PubMed Europe PubMed DOI PMC EPMC
Retzl,B., Hellinger,R., Muratspahic,E., Pinto,M.E.F., Bolzani,V.S. and Gruber,C.W. Discovery of a Beetroot Protease Inhibitor to Identify and Classify Plant-Derived Cystine Knot Peptides J Nat Prod (2020) PubMed Europe PubMed DOI
Smith,D., Cwiklinski,K., Jewhurst,H., Tikhonova,I.G. and Dalton,J.P. An atypical and functionally diverse family of Kunitz-type cysteine/serine proteinase inhibitors secreted by the helminth parasite Fasciola hepatica Sci Rep (2020) 10, 20657-20657. PubMed Europe PubMed DOI PMC EPMC
Totsch,N. and Hoffmann,D. Bayesian Data Integration Questions Classic Study on Protease Self-Digest Kinetics ACS Omega (2020) 5, 15162-15168. PubMed Europe PubMed DOI PMC EPMC

2018

Gallegos,D.A., Sauri,J., Cohen,R.D., Wan,X., Videau,P., Vallota-Eastman,A.O., Shaala,L.A., Youssef,D.T.A., Williamson,R.T., Martin,G.E., Philmus,B., Sikora,A.E., Ishmael,J.E. and McPhail,K.L. Jizanpeptins, cyanobacterial protease inhibitors from a Symploca sp. cyanobacterium collected in the Red Sea J Nat Prod (2018) 81, 1417-1425. PubMed Europe PubMed DOI I
Liu,L., Yu,H., Du,K., Wang,Z., Gan,Y. and Huang,H. Enhanced trypsin thermostability in Pichia pastoris through truncating the flexible region Microb Cell Fact (2018) 17, 165-165. PubMed Europe PubMed DOI PMC EPMC
Perutka,Z. and Sebela,M. Pseudotrypsin: a little-known trypsin proteoform Molecules (2018) 23 PubMed Europe PubMed DOI
Sato,D., Kondo,T. and Kato,T. Dual emissive bispyrene peptide probes for highly sensitive measurements of trypsin activity and evaluation of trypsin inhibitors Bioorg Med Chem (2018) 26, 3468-3473. PubMed Europe PubMed DOI A
Schiebel,J., Gaspari,R., Wulsdorf,T., Ngo,K., Sohn,C., Schrader,T.E., Cavalli,A., Ostermann,A., Heine,A. and Klebe,G. Intriguing role of water in protein-ligand binding studied by neutron crystallography on trypsin complexes Nat Commun (2018) 9, 3559-3559. PubMed Europe PubMed DOI PMC EPMC S
Wang,M., Su,D., Wang,G. and Su,X. A fluorometric sensing method for sensitive detection of trypsin and its inhibitor based on gold nanoclusters and gold nanoparticles Anal Bioanal Chem (2018) 410, 6891-6900. PubMed Europe PubMed DOI A
Wang,Y., Zhou,L., Kang,Q. and Yu,L. Simple and label-free liquid crystal-based sensor for detecting trypsin coupled to the interaction between cationic surfactant and BSA Talanta (2018) 183, 223-227. PubMed Europe PubMed DOI A

2017

Aithal,M., PavanKumar,N.N., Buddha,M., UmamaheshwaraRao,K. and Hazra,P. Kinetic and structural differentiation of trypsin from different origins BioPharm Int (2017) 30, 38-43, 56.
Liu,B., Xiao,H., Li,J., Geng,S., Ma,H. and Liang,G. Interaction of phenolic acids with trypsin: experimental and molecular modeling studies Food Chem (2017) 228, 1-6. PubMed Europe PubMed DOI I
Momeni,L., Mahmodian,S., Shareghi,B., Saboury,A.A. and Farhadian,S. The functional and structural stabilization of trypsin by sucrose Int J Biol Macromol (2017) 99, 343-349. PubMed Europe PubMed DOI
Wu,M., Wang,X., Wang,K. and Guo,Z. An ultrasensitive fluorescent nanosensor for trypsin based on upconversion nanoparticles Talanta (2017) 174, 797-802. PubMed Europe PubMed DOI A
Xia,T., Ma,Q., Hu,T. and Su,X. A novel magnetic/photoluminescence bifunctional nanohybrid for the determination of trypsin Talanta (2017) 170, 286-290. PubMed Europe PubMed DOI A
Zhao,D., Chen,C., Zhao,J., Sun,J. and Yang,X. Label-free fluorescence turn-on strategy for trypsin activity based on thiolate-protected gold nanoclusters with bovine serum albumin as the substrate Sens Actuators, B Chem (2017) 247, 392-399. DOI A

2016

Andre,J., Saleh,D., Syldatk,C. and Hausmann,R. Effect of spacer modification on enzymatic synthetic and hydrolytic activities of immobilized trypsin J Mol Catal B Enzym (2016) 125, 88-96. DOI
Cleary,J.A. and Malthouse,J.P.G. A new lysine derived glyoxal inhibitor of trypsin, its properties and utilization for studying the stabilization of tetrahedral adducts by trypsin Biochem Biophys Rep (2016) 5, 272-284. PubMed Europe PubMed DOI I
Erturk,G., Hedstrom,M. and Mattiasson,B. A sensitive and real-time assay of trypsin by using molecular imprinting-based capacitive biosensor Biosens Bioelectron (2016) 86, 557-565. PubMed Europe PubMed DOI A
Pazhang,M., Mehrnejad,F., Pazhang,Y., Falahati,H. and Chaparzadeh,N. Effect of sorbitol and glycerol on the stability of trypsin and difference between their stabilization effects in the various solvents Biotechnol Appl Biochem (2016) 63, 206-213. PubMed Europe PubMed DOI
Raskovic,B., Vatic,S., Andelkovic,B., Blagojevic,V. and Polovic,N. Optimizing storage conditions to prevent cold denaturation of trypsin for sequencing and to prolong its shelf life Biochem Eng J (2016) 105, 168-176. DOI
Schittmayer,M., Fritz,K., Liesinger,L., Griss,J. and Birner-Gruenberger,R. Cleaning out the litterbox of proteomic scientists' favorite pet: optimized data analysis avoiding trypsin artifacts J Proteome Res (2016) 15, 1222-1229. PubMed Europe PubMed DOI
Zeng,H.J., Wang,Y.P., Yang,R., You,J. and Qu,L.B. Inhibitory effects of daidzein and genistein on trypsin: insights from spectroscopic and molecular docking studies Int J Biol Macromol (2016) 89, 336-343. PubMed Europe PubMed DOI I
Zhao,X.-R., Chen,Y.-L., Wang,L., Wang,W.-F. and Chen,X.-G. Highly sensitive fluorescence detection of trypsin based on gold nanoparticle probes Anal Methods (2016) 8, 393-400. DOI A

2015

Aguirre,C., Condado-Morales,I., Olguin,L.F. and Costas,M. Isothermal titration calorimetry determination of individual rate constants of trypsin catalytic activity Anal Biochem (2015) 479, 18-27. PubMed Europe PubMed DOI
Batt,A.R., St Germain,C.P., Gokey,T., Guliaev,A.B. and Baird,T., Jr. Engineering trypsin for inhibitor resistance Protein Sci (2015) 24, 1463-1474. PubMed Europe PubMed DOI
Burke,M.C., Wang,Y., Lee,A.E., Dixon,E.K., Castaneda,C.A., Fushman,D. and Fenselau,C. Unexpected trypsin cleavage at ubiquitinated lysines Anal Chem (2015) 87, 8144-8148. PubMed Europe PubMed DOI
Cui,F., Yang,K. and Li,Y. Investigate the binding of catechins to trypsin using docking and molecular dynamics simulation PLoS ONE (2015) 10, e0125848- PubMed Europe PubMed DOI PMC EPMC I
Ding,X. and Yang,K.L. Quantitative serine protease assays based on formation of copper(II)-oligopeptide complexes Analyst (2015) 140, 340-345. PubMed Europe PubMed DOI A
Dong,M., Qi,H., Ding,S. and Li,M. Electrochemical determination of trypsin using a heptapeptide substrate self-assembled on a gold electrode Mikrochim Acta (2015) 182, 43-49. DOI A
Dycka,F., Franc,V., Frycak,P., Raus,M., Rehulka,P., Lenobel,R., Allmaier,G., Marchetti-Deschmann,M. and Sebela,M. Evaluation of pseudotrypsin cleavage specificity towards proteins by MALDI-TOF mass spectrometry Protein Pept Lett (2015) 22, 1123-1132. PubMed Europe PubMed P
Gizurarson,J.G. and Filippusson,H. Conjugation of d-glucosamine to bovine trypsin increases thermal stability and alters functional properties Enzyme Microb Technol (2015) 75-76, 1-9. PubMed Europe PubMed DOI
Khangembam,B.K. and Chakrabarti,R. Trypsin from the digestive system of carp Cirrhinus mrigala: purification, characterization and its potential application Food Chem (2015) 175, 386-394. PubMed Europe PubMed DOI
Ou,L.J., Li,X.Y., Li,L.J., Liu,H.W., Sun,A.M. and Liu,K.J. A sensitive assay for trypsin using poly(thymine)-templated copper nanoparticles as fluorescent probes Analyst (2015) 140, 1871-1875. PubMed Europe PubMed DOI A
Pinto,S.C., Rodrigues,A.R., Saraiva,J.A. and Lopes-da-Silva,J.A. Catalytic activity of trypsin entrapped in electrospun poly(epsilon-caprolactone) nanofibers Enzyme Microb Technol (2015) 79-80, 8-18. PubMed Europe PubMed DOI
Shu,M., Shen,W., Wang,X., Wang,F., Ma,L. and Zhai,C. Expression, activation and characterization of porcine trypsin in Pichia pastoris GS115 Protein Expr Purif (2015) 114, 149-155. PubMed Europe PubMed DOI E
Slechtova,T., Gilar,M., Kalikova,K. and Tesarova,E. Insight into trypsin miscleavage: comparison of kinetic constants of problematic peptide sequences Anal Chem (2015) 87, 7636-7643. PubMed Europe PubMed DOI P
Yang,M., Huang,X., Zhang,Y.-W., Ping,X.-Q., Long,J. and Cao,R.-Y. Cloning and expression of porcine trypsin mutant gene in Escherichia coli and its activity analysis Chin J Pharm Biotechnol (2015) 22, 283-287. E
Zhao,M., Wu,F. and Xu,P. Development of a rapid high-efficiency scalable process for acetylated Sus scrofa cationic trypsin production from Escherichia coli inclusion bodies Protein Expr Purif (2015) 116, 120-126. PubMed Europe PubMed DOI E

2014

Boechi,L., Pierce,L., Komives,E.A. and McCammon,J.A. Trypsinogen activation as observed in accelerated molecular dynamics simulations Protein Sci (2014) 23, 1550-1558. PubMed Europe PubMed DOI
Buettner,K., Kreisig,T., Strater,N. and Zuchner,T. Protein surface charge of trypsinogen changes its activation pattern BMC Biotechnol (2014) 14, 960-960. PubMed Europe PubMed DOI
Castello Serrano,I., Stoica,G., Matas Adams,A. and Palomares,E. Dual core quantum dots for highly quantitative ratiometric detection of trypsin activity in cystic fibrosis patients Nanoscale (2014) 6, 13623-13629. PubMed Europe PubMed DOI A
Ding,X., Ge,D. and Yang,K.-L. Colorimetric protease assay by using gold nanoparticles and oligopeptides Sens Actuators, B Chem (2014) 201, 234-239. DOI A
Franke,L., Liebscher,S. and Bordusa,F. Engineering the oxyanion hole of trypsin for promoting the reverse of proteolysis J Pept Sci (2014) 20, 128-136. PubMed Europe PubMed DOI
Gershon,P.D. Cleaved and missed sites for trypsin, Lys-C, and Lys-N can be predicted with high confidence on the basis of sequence context J Proteome Res (2014) 13, 702-709. PubMed Europe PubMed DOI P
Hong,M.L., Li,L.J., Han,H.X. and Chu,X. A label-free fluorescence assay for trypsin based on the electron transfer between oligonucleotide-stabilized ag nanoclusters and cytochrome c Anal Sci (2014) 30, 811-815. PubMed Europe PubMed A
Kim,N.-S., Yu,H.-Y., Chung,N.-D., Kwon,T.-H. and Yang,M.-S. High-level production of recombinant trypsin in transgenic rice cell culture through utilization of an alternative carbon source and recycling system Enzyme Microb Technol (2014) 63, 21-27. PubMed Europe PubMed DOI E
Lacerda,C.D., Teixeira,A.E., Oliveira,J.S., Silva,S.F., Vasconcelos,A.V., Gouveia,D.G., Silva,A.R., Santoro,M.M., Mares-Guia,M.L. and Santos,A.M. Gamma trypsin: Purification and physicochemical characterization of a novel bovine trypsin isoform Int J Biol Macromol (2014) 70, 179-186. PubMed Europe PubMed DOI
Liebscher,S., Schopfel,M., Aumuller,T., Sharkhuukhen,A., Pech,A., Hoss,E., Parthier,C., Jahreis,G., Stubbs,M.T. and Bordusa,F. N-Terminal protein modification by substrate-activated reverse proteolysis Angew Chem Int Ed Engl (2014) 53, 3024-3028. PubMed Europe PubMed DOI
Pan,Y., Cheng,K., Mao,J., Liu,F., Liu,J., Ye,M. and Zou,H. Quantitative proteomics reveals the kinetics of trypsin-catalyzed protein digestion Anal Bioanal Chem (2014) 406, 6247-6256. PubMed Europe PubMed DOI P
Weiz,A.R., Ishida,K., Quitterer,F., Meyer,S., Kehr,J.C., Muller,K.M., Groll,M., Hertweck,C. and Dittmann,E. Harnessing the evolvability of tricyclic microviridins to dissect protease-inhibitor interactions Angew Chem Int Ed Engl (2014) 53, 3735-3738. PubMed Europe PubMed DOI S I

2013

Bunkenborg,J., Espadas,G. and Molina,H. Cutting edge proteomics: benchmarking of six commercial trypsins J Proteome Res (2013) 12, 3631-3641. PubMed Europe PubMed DOI P
Crowell,A.M., Stewart,E.J., Take,Z.S. and Doucette,A.A. Critical assessment of the spectroscopic activity assay for monitoring trypsin activity in organic-aqueous solvent Anal Biochem (2013) 435, 131-136. PubMed Europe PubMed DOI A
Ganachaud,C., Bernin,D., Isaksson,D. and Holmberg,K. An anomalous behavior of trypsin immobilized in alginate network Appl Microbiol Biotechnol (2013) 97, 4403-4414. PubMed Europe PubMed DOI
Karna,N., Debowski,D., Gitlin,A., Legowska,A. and Rolka,K. Investigation of peptide splicing using two-peptide-chain analogs of trypsin inhibitor SFTI-1 FEBS J (2013) 280, 6213-6222. PubMed Europe PubMed DOI
Liebschner,D., Dauter,M., Brzuszkiewicz,A. and Dauter,Z. On the reproducibility of protein crystal structures: five atomic resolution structures of trypsin Acta Crystallogr D Biol Crystallogr (2013) 69, 1447-1462. PubMed Europe PubMed DOI PMC EPMC S
Liu,F., Ye,M., Wang,C., Hu,Z., Zhang,Y., Qin,H., Cheng,K. and Zou,H. Polyacrylamide gel with switchable trypsin activity for analysis of proteins Anal Chem (2013) 85, 7024-7028. PubMed Europe PubMed DOI
Masuda,Y., Nitanai,Y., Mizutani,R. and Noguchi,S. Crystal structure of 6-guanidinohexanoyl trypsin near the optimum pH reveals the acyl-enzyme intermediate to be deacylated Proteins (2013) 81, 526-530. PubMed Europe PubMed DOI S
Meng,Y., Yuan,Y., Zhu,Y., Guo,Y., Li,M., Wang,Z., Pu,X. and Jiang,L. Effects of organic solvents and substrate binding on trypsin in acetonitrile and hexane media J Mol Model (2013) 19, 3749-3766. PubMed Europe PubMed DOI
Vandermarliere,E., Mueller,M. and Martens,L. Getting intimate with trypsin, the leading protease in proteomics Mass Spectrom Rev (2013) 32, 453-465. PubMed Europe PubMed DOI P
Zhang,H., Zhou,Q., Cao,J. and Wang,Y. Mechanism of cinnamic acid-induced trypsin inhibition: a multi-technique approach Spectrochim Acta A Mol Biomol Spectrosc (2013) 116, 251-257. PubMed Europe PubMed DOI
Zheng,H., Mei,Y.J., Du,K., Shi,Q.Y. and Zhang,P.F. Trypsin-catalyzed one-pot multicomponent synthesis of 4-thiazolidinones Catal Lett (2013) 143, 298-301. DOI

2012

Baird,T.T., Jr. and Craik,C.S. Trypsin [ISSN:978-0-12-407742-3] (2012) 3, 2594-2600. DOI
Dosa,S., Stirnberg,M., Lulsdorff,V., Haussler,D., Maurer,E. and Gutschow,M. Active site mapping of trypsin, thrombin and matriptase-2 by sulfamoyl benzamidines Bioorg Med Chem (2012) 20, 6489-6505. PubMed Europe PubMed DOI I
Gokey,T., Baird,T.T., Jr. and Guliaev,A.B. Conformational dynamics of threonine 195 and the S1 subsite in functional trypsin variants J Mol Model (2012) 18, 4941-4954. PubMed Europe PubMed DOI
Salameh,M.A., Soares,A.S., Alloy,A. and Radisky,E.S. Presence versus absence of hydrogen bond donor Tyr-39 influences interactions of cationic trypsin and mesotrypsin with protein protease inhibitors Protein Sci (2012) 21, 1103-1112. PubMed Europe PubMed DOI S

2011

Brandt,T., Holzmann,N., Muley,L., Khayat,M., Wegscheid-Gerlach,C., Baum,B., Heine,A., Hangauer,D. and Klebe,G. Congeneric but still distinct: how closely related trypsin ligands exhibit different thermodynamic and structural properties J Mol Biol (2011) 405, 1170-1187. PubMed Europe PubMed DOI I
Iyaguchi,D. Inhibition mechanism of trypsin by Schiff base metal chelate inhibitors Yakugaku Zasshi (2011) 131, 1299-1303. PubMed Europe PubMed DOI I
Kawamura,K., Yamada,T., Kurihara,K., Tamada,T., Kuroki,R., Tanaka,I., Takahashi,H. and Niimura,N. X-ray and neutron protein crystallographic analysis of the trypsin-BPTI complex Acta Crystallogr D Biol Crystallogr (2011) 67, 140-148. PubMed Europe PubMed DOI S
Kim,N.S., Yu,H.Y., Chung,N.D., Shin,Y.J., Kwon,T.H. and Yang,M.S. Production of functional recombinant bovine trypsin in transgenic rice cell suspension cultures Protein Expr Purif (2011) 76, 121-126. PubMed Europe PubMed DOI E
Li,P., Liu,Y., Wang,X. and Tang,B. A new FRET nanoprobe for trypsin using a bridged beta-cyclodextrin dimer-dye complex and its biological imaging applications Analyst (2011) 136, 4520-4525. PubMed Europe PubMed DOI
Marques,D., Pessela,B.C., Betancor,L., Monti,R., Carrascosa,A.V., Rocha-Martin,J., Guisan,J.M. and Fernandez-Lorente,G. Protein hydrolysis by immobilized and stabilized trypsin Biotechnol Prog (2011) 27, 677-683. PubMed Europe PubMed DOI
Mu,Y., Lin,J. and Liu,R. Interaction of sodium benzoate with trypsin by spectroscopic techniques Spectrochim Acta A Mol Biomol Spectrosc (2011) 83, 130-135. PubMed Europe PubMed DOI
Ray,K. and Jalili,P.R. Characterization of TrypZean: a plant-based alternative to bovine-derived trypsin BioPharm Int (2011) 24, 44-48. E
Ruark,C.D., Hack,C.E., Robinson,P.J. and Gearhart,J.M. Quantitative structure-activity relationships for organophosphates binding to trypsin and chymotrypsin J Toxicol Environ Health A (2011) 74, 1-23. PubMed Europe PubMed DOI I
Schopfel,M., Tziridis,A., Arnold,U. and Stubbs,M.T. Towards a restriction proteinase: construction of a self-activating enzyme Chembiochem (2011) 12, 1523-1527. PubMed Europe PubMed DOI
Wahlgren,W.Y., Pal,G., Kardos,J., Porrogi,P., Szenthe,B., Patthy,A., Graf,L. and Katona,G. The catalytic aspartate is protonated in the Michaelis complex formed between trypsin and an in vitro evolved substrate-like inhibitor: a refined mechanism of serine protease action J Biol Chem (2011) 286, 3587-3596. PubMed Europe PubMed DOI S
Xue,W., Zhang,G. and Zhang,D. A sensitive colorimetric label-free assay for trypsin and inhibitor screening with gold nanoparticles Analyst (2011) 136, 3136-3141. PubMed Europe PubMed DOI A
Zhou,Y. and Zhang,Y. Serine protease acylation proceeds with a subtle re-orientation of the histidine ring at the tetrahedral intermediate Chem Commun (Camb) (2011) 47, 1577-1579. PubMed Europe PubMed DOI

2010

Chai,S.J., Lai,Y.F., Zheng,H. and Zhang,P.F. A novel trypsin-catalyzed three-component Mannich reaction Helv Chim Acta (2010) 93, 2231-2236. DOI
Kawamura,K., Yamada,T., Kurihara,K., Tamada,T., Kuroki,R., Tanaka,I., Takahashi,H. and Niimura,N. A preliminary neutron crystallography on the trypsin-bovine pancreatic trypsin inhibitor complex J Phys Conf Ser (2010) 251, 012033-012033. DOI S
Mannocci,L., Melkko,S., Buller,F., Molnar,I., Bianke,J.P., Dumelin,C.E., Scheuermann,J. and Neri,D. Isolation of potent and specific trypsin inhibitors from a DNA-encoded chemical library Bioconjug Chem (2010) 21, 1836-1841. PubMed Europe PubMed DOI I
Wartmann,T., Mayerle,J., Kahne,T., Sahin-Toth,M., Ruthenburger,M., Matthias,R., Kruse,A., Reinheckel,T., Peters,C., Weiss,F.U., Sendler,M., Lippert,H., Schulz,H.U., Aghdassi,A., Dummer,A., Teller,S., Halangk,W. and Lerch,M.M. Cathepsin L inactivates human trypsinogen, whereas cathepsin L-deletion reduces the severity of pancreatitis in mice Gastroenterology (2010) 138, 726-737. PubMed Europe PubMed DOI
Zhang,H., Huang,R.Y., Jalili,P.R., Irungu,J.W., Nicol,G.R., Ray,K.B., Rohrs,H.W. and Gross,M.L. Improved mass spectrometric characterization of protein glycosylation reveals unusual glycosylation of maize-derived bovine trypsin Anal Chem (2010) 82, 10095-10101. PubMed Europe PubMed DOI E

2009

Di Cera,E. Serine proteases IUBMB Life (2009) 61, 510-515. PubMed Europe PubMed DOI PMC EPMC V
Kereszturi,E., Szmola,R., Kukor,Z., Simon,P., Weiss,F.U., Lerch,M.M. and Sahin-Toth,M. Hereditary pancreatitis caused by mutation-induced misfolding of human cationic trypsinogen: a novel disease mechanism Hum Mutat (2009) 30, 575-582. PubMed Europe PubMed DOI PMC EPMC M
Zakharova,E., Horvath,M.P. and Goldenberg,D.P. Structure of a serine protease poised to resynthesize a peptide bond Proc Natl Acad Sci U S A (2009) 106, 11034-11039. PubMed Europe PubMed DOI PMC EPMC

2008

Gombos,L., Kardos,J., Patthy,A., Medveczky,P., Szilagyi,L., Malnasi-Csizmadia,A. and Graf,L. Probing conformational plasticity of the activation domain of trypsin: the role of glycine hinges Biochemistry (2008) 47, 1675-1684. PubMed Europe PubMed DOI
Rodriguez,J., Gupta,N., Smith,R.D. and Pevzner,P.A. Does trypsin cut before proline? J Proteome Res (2008) 7, 300-305. PubMed Europe PubMed DOI P

2007

Baumann,H.I., Keller,S., Wolter,F.E., Nicholson,G.J., Jung,G., Sussmuth,R.D. and Juttner,F. Planktocyclin, a cyclooctapeptide protease inhibitor produced by the freshwater cyanobacterium Planktothrix rubescens J Nat Prod (2007) 70, 1611-1615. PubMed Europe PubMed DOI I
Czodrowski,P., Sotriffer,C.A. and Klebe,G. Protonation changes upon ligand binding to trypsin and thrombin: structural interpretation based on pK(a) calculations and ITC experiments J Mol Biol (2007) 367, 1347-1356. PubMed Europe PubMed DOI
Di Fenza,A., Heine,A., Koert,U. and Klebe,G. Understanding binding selectivity toward trypsin and factor Xa: the role of aromatic interactions ChemMedChem (2007) 2, 297-308. PubMed Europe PubMed DOI I
Ito,T., Sugita,Y., Takao,K., Ikeguchi,Y. and Shirahata,A. Amine modification of digested peptide at C-terminal end during protein digestion by protease Biol Pharm Bull (2007) 30, 1838-1843. PubMed Europe PubMed DOI
Manea,M., Mezo,G., Hudecz,F. and Przybylski,M. Mass spectrometric identification of the trypsin cleavage pathway in lysyl-proline containing oligotuftsin peptides J Pept Sci (2007) 13, 227-236. PubMed Europe PubMed DOI P
Sherawat,M., Kaur,P., Perbandt,M., Betzel,C., Slusarchyk,W.A., Bisacchi,G.S., Chang,C., Jacobson,B.L., Einspahr,H.M. and Singh,T.P. Structure of the complex of trypsin with a highly potent synthetic inhibitor at 0.97 A resolution Acta Crystallogr D Biol Crystallogr (2007) 63, 500-507. PubMed Europe PubMed DOI S I

2006

[YEAR:22-9-2006]Angel,P.M. and Orlando,R. Trypsin is the primary mechanism by which the (18)O isotopic label is lost in quantitative proteomic studies Anal Biochem (22-9-2006) 359, 26-34. PubMed Europe PubMed DOI
[YEAR:2-5-2006]Baird,T.T., Jr., Wright,W.D. and Craik,C.S. Conversion of trypsin to a functional threonine protease Protein Sci (2-5-2006) 15, 1229-1238. PubMed Europe PubMed DOI PMC EPMC
[YEAR:6-3-2006]Caracciolo,G., Martelli,A., Boumis,G., Bellelli,A., Caminiti,R., Congiu-Castellano,A. and Amiconi,G. Conformational changes of bovine beta-trypsin and trypsinogen induced by divalent ions: an energy-dispersive X-ray diffraction and functional study Arch Biochem Biophys (6-3-2006) 449, 157-163. PubMed Europe PubMed DOI
[YEAR:2-5-2006]Ishida,T. Low-barrier hydrogen bond hypothesis in the catalytic triad residue of serine proteases: correlation between structural rearrangement and chemical shifts in the acylation process Biochemistry (2-5-2006) 45, 5413-5420. PubMed Europe PubMed DOI
[YEAR:26-6-2006]Paul,J.J., Kircus,S.R., Sorrell,T.N., Ropp,P.A. and Thorp,H.H. Effects of coordinating metal Ions on the mediated inhibition of trypsin by bis(benzimidazoles) and related compounds Inorg Chem (26-6-2006) 45, 5126-5135. PubMed Europe PubMed DOI I
[YEAR:2-5-2006]Radisky,E.S., Lee,J.M., Lu,C.J. and Koshland,D.E., Jr. Insights into the serine protease mechanism from atomic resolution structures of trypsin reaction intermediates Proc Natl Acad Sci U S A (2-5-2006) 103, 6835-6840. PubMed Europe PubMed DOI PMC EPMC S
Shibli,A., Smoum,R., Goldberg,I., Rubinstein,A. and Srebnik,M. alpha-Amino boronates as cyanoborane complexes: crystal structure and inhibition properties for the serine proteases: alpha-chymotrypsin and trypsin Appl Organomet Chem (2006) 20, 459-462. DOI S I
Transue,T.R., Gabel,S.A. and London,R.E. NMR and crystallographic characterization of adventitious borate binding by trypsin Bioconjug Chem (2006) 17, 300-308. PubMed Europe PubMed DOI S I

2005

[YEAR:1-2-2005]Guvench,O., Price,D.J. and Brooks,C.L., III Receptor rigidity and ligand mobility in trypsin-ligand complexes Proteins (1-2-2005) 58, 407-417. PubMed Europe PubMed DOI
Shamaladevi,N. and Pattabhi,V. Secondary binding site of trypsin: revealed by crystal structure of trypsin-peptide complex J Biomol Struct Dyn (2005) 22, 635-642. PubMed Europe PubMed DOI S
[YEAR:5-8-2005]Yang,L., Gao,Z., Cao,Y., Xing,R. and Zhang,X. Effect of PbII on the secondary structure and biological activity of trypsin Chembiochem (5-8-2005) 6, 1191-1195. PubMed Europe PubMed DOI

2004

Halfon,S., Baird,T.T., Jr. and Craik,C.S. Trypsin [ISSN:0-12-079610-4] (2004) 2, 1483-1488. V
[YEAR:1-4-2004]Khajehpour,M., Troxler,T. and Vanderkooi,J.M. Probing the active site of trypsin with rose bengal: insights into the photodynamic inactivation of the enzyme Photochem Photobiol (1-4-2004) 80, 359-365. PubMed Europe PubMed DOI
Leiros,H.K., Brandsdal,B.O., Andersen,O.A., Os,V., Leiros,I., Helland,R., Otlewski,J., Willassen,N.P. and Smalas,A.O. Trypsin specificity as elucidated by LIE calculations, X-ray structures, and association constant measurements Protein Sci (2004) 13, 1056-1070. PubMed Europe PubMed DOI PMC EPMC S
[YEAR:19-3-2004]Olsen,J.V., Ong,S.E. and Mann,M. Trypsin cleaves exclusively C-terminal to arginine and lysine residues Mol Cell Proteomics (19-3-2004) 3, 608-614. PubMed Europe PubMed DOI
Rauh,D., Klebe,G. and Stubbs,M.T. Understanding protein-ligand interactions: the price of protein flexibility J Mol Biol (2004) 335, 1325-1341. PubMed Europe PubMed DOI S
Transue,T.R., Krahn,J.M., Gabel,S.A., DeRose,E.F. and London,R.E. X-ray and NMR characterization of covalent complexes of trypsin, borate, and alcohols Biochemistry (2004) 43, 2829-2839. PubMed Europe PubMed DOI S I
[YEAR:18-6-2004]Zablotna,E., Dysasz,H., Lesner,A., Jaskiewicz,A., Kazmierczak,K., Miecznikowska,H. and Rolka,K. A simple method for selection of trypsin chromogenic substrates using combinatorial chemistry approach Biochem Biophys Res Commun (18-6-2004) 319, 185-188. PubMed Europe PubMed DOI A

2003

Chen,J.M., Kukor,Z., Le Marechal,C., Toth,M., Tsakiris,L., Raguenes,O., Ferec,C. and Sahin-Toth,M. Evolution of trypsinogen activation peptides Mol Biol Evol (2003) 20, 1767-1777. PubMed Europe PubMed DOI
Hanquier,J., Sorlet,Y., Desplancq,D., Baroche,L., Ebtinger,M., Lefevre,J.F., Pattus,F., Hershberger,C.L. and Vertes,A.A. A single mutation in the activation site of bovine trypsinogen enhances its accumulation in the fermentation broth of the yeast Pichia pastoris Appl Environ Microbiol (2003) 69, 1108-1113. PubMed Europe PubMed DOI PMC EPMC E
[YEAR:31-10-2003]Helland,R., Czapinska,H., Leiros,I., Olufsen,M., Otlewski,J. and Smalas,A.O. Structural consequences of accommodation of four non-cognate amino acid residues in the S1 pocket of bovine trypsin and chymotrypsin J Mol Biol (31-10-2003) 333, 845-861. PubMed Europe PubMed DOI
[YEAR:31-10-2003]Schmidt,A., Jelsch,C., Ostergaard,P., Rypniewski,W. and Lamzin,V.S. Trypsin revisited: crystallography at (sub) atomic resolution and quantum chemistry revealing details of catalysis J Biol Chem (31-10-2003) 278, 43357-43362. PubMed Europe PubMed DOI S

2002

Bianchini,E.P., Louvain,V.B., Marque,P.E., Juliano,M.A., Juliano,L. and le Bonniec,B.F. Mapping of the catalytic groove preferences of factor Xa reveals an inadequate selectivity for its macromolecule substrates J Biol Chem (2002) 277, 20527-20534. PubMed Europe PubMed DOI P
Cuesta-Seijo,J.A. and Garcia-Granda,S. Trypsin as a model for high resolution X-ray diffraction in proteins Bol R Soc Hist Nat Sec Geol (2002) 97, 123-129.
Cui,J., Marankan,F., Fu,W., Crich,D., Mesecar,A. and Johnson,M.E. An oxyanion-hole selective serine protease inhibitor in complex with trypsin Bioorg Med Chem (2002) 10, 41-46. PubMed Europe PubMed DOI S
Johnson,K.D., Clark,A. and Marshall,S. A functional comparison of ovine and porcine trypsins Comp Biochem Physiol B Biochem Mol Biol (2002) 131, 423-431. PubMed Europe PubMed DOI I

2001

Darvesh,S., Kumar,R., Roberts,S., Walsh,R. and Martin,E. Butyrylcholinesterase-mediated enhancement of the enzymatic activity of trypsin Cell Mol Neurobiol (2001) 21, 285-296. PubMed Europe PubMed DOI
Dormitzer,P.R., Greenberg,H.B. and Harrison,S.C. Proteolysis of monomeric recombinant rotavirus VP4 yields an oligomeric VP5*core J Virol (2001) 75, 7339-7350. PubMed Europe PubMed DOI PMC EPMC
Katz,B.A., Sprengeler,P.A., Luong,C., Verner,E., Elrod,K., Kirtley,M., Janc,J., Spencer,J.R., Breitenbucher,J.G., Hui,H., McGee,D., Allen,D., Martelli,A. and Mackman,R.L. Engineering inhibitors highly selective for the S1 sites of Ser190 trypsin-like serine protease drug targets Chem Biol (2001) 8, 1107-1121. PubMed Europe PubMed DOI S
Leiros,H.K., McSweeney,S.M. and Smalas,A.O. Atomic resolution structures of trypsin provide insight into structural radiation damage Acta Crystallogr D Biol Crystallogr (2001) 57, 488-497. PubMed Europe PubMed DOI S
[YEAR:3-8-2001]Lesner,A., Kupryszewski,G. and Rolka,K. Chromogenic substrates of bovine beta-trypsin: the influence of an amino acid residue in P1 position on their interaction with the enzyme Biochem Biophys Res Commun (3-8-2001) 285, 1350-1353. PubMed Europe PubMed DOI A P
O'Reilly,D.A., Yang,B.M., Creighton,J.E., Demaine,A.G. and Kingsnorth,A.N. Mutations of the cationic trypsinogen gene in hereditary and non-hereditary pancreatitis Digestion (2001) 64, 54-60. PubMed Europe PubMed DOI M
Pasternak,A., White,A., Jeffery,C.J., Medina,N., Cahoon,M., Ringe,D. and Hedstrom,L. The energetic cost of induced fit catalysis: crystal structures of trypsinogen mutants with enhanced activity and inhibitor affinity Protein Sci (2001) 10, 1331-1342. PubMed Europe PubMed DOI PMC EPMC
Tomoo,K., Satoh,K., Tsuda,Y., Wanaka,K., Okamoto,S., Hijikata-Okunomiya,A., Okada,Y. and Ishida,T. Binding diversity of a noncovalent-type low-molecular-weight serine protease inhibitor and function of a catalytic water molecule: X-ray crystal structure of PKSI-527-inhibited trypsin J Biochem (2001) 129, 455-460. PubMed Europe PubMed S I
[YEAR:19-1-2001]Toyota,E., Ng,K.K., Sekizaki,H., Itoh,K., Tanizawa,K. and James,M.N. X-ray crystallographic analyses of complexes between bovine beta-trypsin and Schiff base copper(II) or iron(III) chelates J Mol Biol (19-1-2001) 305, 471-479. PubMed Europe PubMed DOI S
[YEAR:9-3-2001]Xu,S., Rall,K. and Bordusa,F. Enzymatic coupling of specific peptides at nonspecific ligation sites: effect of Asp189Glu mutation in trypsin on substrate mimetic-mediated reactions J Org Chem (9-3-2001) 66, 1627-1632. PubMed Europe PubMed DOI

2000

Bass,D.M. and Qiu,S. Proteolytic processing of the astrovirus capsid J Virol (2000) 74, 1810-1814. PubMed Europe PubMed DOI PMC EPMC
[YEAR:5-7-2000]Harris,J.L., Backes,B.J., Leonetti,F., Mahrus,S., Ellman,J.A. and Craik,C.S. Rapid and general profiling of protease specificity by using combinatorial fluorogenic substrate libraries Proc Natl Acad Sci U S A (5-7-2000) 97, 7754-7759. PubMed Europe PubMed DOI PMC EPMC P
Hijikata-Okunomiya,A., Tamao,Y., Kikumoto,R. and Okamoto,S. Selective inhibition of trypsin by (2R,4R)-4-phenyl-1-[Nalpha-(7-methoxy-2-naphthalenesulfonyl)-L-arginyl]-2-piperidinecarboxylic acid J Biol Chem (2000) 275, 18995-18999. PubMed Europe PubMed DOI I
Katz,B.A., Mackman,R., Luong,C., Radika,K., Martelli,A., Sprengeler,P.A., Wang,J., Chan,H. and Wong,L. Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator Chem Biol (2000) 7, 299-312. PubMed Europe PubMed DOI S
Rester,U., Moser,M., Huber,R. and Bode,W. L-Isoaspartate 115 of porcine beta-trypsin promotes crystallization of its complex with bdellastasin Acta Crystallogr D Biol Crystallogr (2000) 56, 581-588. PubMed Europe PubMed DOI S

1999

[YEAR:16-11-1999]Johnson,A., Gautham,N. and Pattabhi,V. Crystal structure at 1.63 A resolution of the native form of porcine beta-trypsin: revealing an acetate ion binding site and functional water network Biochim Biophys Acta (16-11-1999) 1435, 7-21. PubMed Europe PubMed DOI S
Katz,B.A. and Luong,C. Recruiting Zn2+ to mediate potent, specific inhibition of serine proteases J Mol Biol (1999) 292, 669-684. PubMed Europe PubMed DOI S I
Otani,T. and Matsukura,A. Cathepsin B inhibitors do not prevent the intracellular trypsinogen activation by secretagogue hyperstimulation Pancreas (1999) 19, 210-211. PubMed Europe PubMed I
Pasternak,A., Ringe,D. and Hedstrom,L. Comparison of anionic and cationic trypsinogens: the anionic activation domain is more flexible in solution and differs in its mode of BPTI binding in the crystal structure Protein Sci (1999) 8, 253-258. PubMed Europe PubMed DOI PMC EPMC
Polticelli,F., Ascenzi,P., Bolognesi,M. and Honig,B. Structural determinants of trypsin affinity and specificity for cationic inhibitors Protein Sci (1999) 8, 2621-2629. PubMed Europe PubMed DOI PMC EPMC I
Recacha,R., Carson,M., Costanzo,M.J., Maryanoff,B., DeLucas,L.J. and Chattopadhyay,D. Structure of the RWJ-51084-bovine pancreatic beta-trypsin complex at 1.8 A Acta Crystallogr D Biol Crystallogr (1999) 55, 1785-1791. PubMed Europe PubMed DOI S I
Szabo,E., Bocskei,Z., Naray-Szabo,G. and Graf,L. The three-dimensional structure of Asp189Ser trypsin provides evidence for an inherent structural plasticity of the protease Eur J Biochem (1999) 263, 20-26. PubMed Europe PubMed DOI
[YEAR:8-1-1999]Wu,C., Robertson,D.H., Hubbard,S.J., Gaskell,S.J. and Beynon,R.J. Proteolysis of native proteins. Trapping of a reaction intermediate J Biol Chem (8-1-1999) 274, 1108-1115. PubMed Europe PubMed DOI
Zhu,Y., Huang,Q., Qian,M., Jia,Y. and Tang,Y. Crystal structure of the complex formed between bovine beta-trypsin and MCTI-A, a trypsin inhibitor of squash family, at 1.8-A resolution J Protein Chem (1999) 18, 505-509. PubMed Europe PubMed DOI S

1998

Chobert,J.M., Briand,L. and Haertle,T. Influence of G187W/K188F/D189Y mutation in the substrate binding pocket of trypsin on beta-casein processing J Food Biochem (1998) 22, 529-545. DOI
[YEAR:15-12-1998]Grahn,S., Ullmann,D. and Jakubke,H. Design and synthesis of fluorogenic trypsin peptide substrates based on resonance energy transfer Anal Biochem (15-12-1998) 265, 225-231. PubMed Europe PubMed DOI A
Katz,B.A., Clark,J.M., Finer-Moore,J.S., Jenkins,T.E., Johnson,C.R., Ross,M.J., Luong,C., Moore,W.R. and Stroud,R.M. Design of potent selective zinc-mediated serine protease inhibitors Nature (1998) 391, 608-612. PubMed Europe PubMed DOI S I
Krishnan,R., Zhang,E., Hakansson,K., Arni,R.K., Tulinsky,A., Lim-Wilby,M.S., Levy,O.E., Semple,J.E. and Brunck,T.K. Highly selective mechanism-based thrombin inhibitors: structures of thrombin and trypsin inhibited with rigid peptidyl aldehydes Biochemistry (1998) 37, 12094-12103. PubMed Europe PubMed DOI S I
Ni,L.M. and Powers,J.C. Synthesis and kinetic studies of an amidine-containing phosphonofluoridate: a novel potent inhibitor of trypsin-like enzymes Bioorg Med Chem (1998) 6, 1767-1773. PubMed Europe PubMed DOI I
[YEAR:1-12-1998]Presnell,S.R., Patil,G.S., Mura,C., Jude,K.M., Conley,J.M., Bertrand,J.A., Kam,C.M., Powers,J.C. and Williams,L.D. Oxyanion-mediated inhibition of serine proteases Biochemistry (1-12-1998) 37, 17068-17081. PubMed Europe PubMed DOI S I
Varallyay,E., Pal,G., Patthy,A., Szilagyi,L. and Graf,L. Two mutations in rat trypsin confer resistance against autolysis Biochem Biophys Res Commun (1998) 243, 56-60. PubMed Europe PubMed DOI

1997

Kaslik,G., Kardos,J., Szabo,E., Szilagyi,L., Zavodszky,P., Westler,W.M., Markley,J.L. and Graf,L. Effects of serpin binding on the target proteinase: global stabilization, localized increased structural flexibility, and conserved hydrogen bonding at the active site Biochemistry (1997) 36, 5455-5464. PubMed Europe PubMed DOI
Kurth,T., Ullmann,D., Jakubke,H.D. and Hedstrom,L. Converting trypsin to chymotrypsin: Structural determinants of S1' specificity Biochemistry (1997) 36, 10098-10104. PubMed Europe PubMed DOI
Li,X.F., Tang,J.G. and Zhang,L.X. Autolytic site mutant R105C of rat trypsin Biochem Mol Biol Int (1997) 42, 991-996. PubMed Europe PubMed E
Roach,J.C., Wang,K., Gan,L. and Hood,L. The molecular evolution of the vertebrate trypsinogens J Mol Evol (1997) 45, 640-652. PubMed Europe PubMed DOI
Takahashi,K. Restriction of the specificities of trypsin and alpha-chymotrypsin at a high alkaline pH value Protein Pept Lett (1997) 4, 33-38.
Varallyay,E., Lengyel,Z., Graf,L. and Szilagyi,L. The role of disulfide bond C191-C220 in trypsin and chymotrypsin Biochem Biophys Res Commun (1997) 230, 592-596. PubMed Europe PubMed DOI

1996

[YEAR:12-3-1996]Bertrand,J.A., Oleksyszyn,J., Kam,C.M., Boduszek,B., Presnell,S., Plaskon,R.R., Suddath,F.L., Powers,J.C. and Williams,L.D. Inhibition of trypsin and thrombin by amino(4-amidinophenyl)methanephosphonate diphenyl ester derivatives: X-ray structures and molecular models Biochemistry (12-3-1996) 35, 3147-3155. PubMed Europe PubMed DOI S I
Hedstrom,L., Lin,T.Y. and Fast,W. Hydrophobic interactions control zymogen activation in the trypsin family of serine proteases Biochemistry (1996) 35, 4515-4523. PubMed Europe PubMed DOI
Hedstrom,L. Trypsin: a case study in the structural determinants of enzyme specificity Biol Chem (1996) 377, 465-470. PubMed Europe PubMed
Kurinov,I.V. and Harrison,R.W. Two crystal structures of the leupeptin-trypsin complex Protein Sci (1996) 5, 752-758. PubMed Europe PubMed DOI PMC EPMC S I
Sreedharan,S.K., Verma,C., Caves,L.S., Brocklehurst,S.M., Gharbia,S.E., Shah,H.N. and Brocklehurst,K. Demonstration that 1-trans-epoxysuccinyl-L-leucylamido- (4-guanidino)butane (E-64) is one of the most effective low Mr inhibitors of trypsin-catalysed hydrolysis. Characterization by kinetic analysis and by energy minimization and molecular dynamics simulation of the E-64-beta-trypsin complex Biochem J (1996) 316, 777-786. PubMed Europe PubMed PMC EPMC I

1995

Matsuzaki,T., Umeyama,H. and Kikumoto,R. Mechanisms of the selective inhibition of thrombin, factor Xa, plasmin and trypsin Pharmacochem Libr (1995) 23, 83-95. DOI S I
Odagaki,Y., Nakai,H., Senokuchi,K., Kawamura,M., Hamanaka,N., Nakamura,M., Tomoo,K. and Ishida,T. Unique binding of a novel synthetic inhibitor, N-[3-[4-[4-(amidinophenoxy)carbonyl]phenyl]-2-methyl-2-propenoyl]-N-allylglycine methanesulfonate, to bovine trypsin, revealed by the crystal structure of the complex Biochemistry (1995) 34, 12849-12853. PubMed Europe PubMed DOI S I

1994

[YEAR:26-7-1994]Hedstrom,L., Perona,J.J. and Rutter,W.J. Converting trypsin to chymotrypsin: residue 172 is a substrate specificity determinant Biochemistry (26-7-1994) 33, 8757-8763. PubMed Europe PubMed DOI
[YEAR:26-7-1994]Hedstrom,L., Farr-Jones,S., Kettner,C.A. and Rutter,W.J. Converting trypsin to chymotrypsin: ground-state binding does not determine substrate specificity Biochemistry (26-7-1994) 33, 8764-8769. PubMed Europe PubMed DOI I
Huang,Q., Wang,Z., Li,Y., Liu,S. and Tang,Y. Refined 1.8 A resolution crystal structure of the porcine epsilon-trypsin Biochim Biophys Acta (1994) 1209, 77-82. PubMed Europe PubMed DOI S
Lee,A.Y., Smitka,T.A., Bonjouklian,R. and Clardy,J. Atomic structure of the trypsin-A90720A complex: a unified approach to structure and function Chem Biol (1994) 1, 113-117. PubMed Europe PubMed DOI S I
Rypniewski,W.R., Perrakis,A., Vorgias,C.E. and Wilson,K.S. Evolutionary divergence and conservation of trypsin Protein Eng (1994) 7, 57-64. PubMed Europe PubMed
[YEAR:12-4-1994]Schellenberger,V., Turck,C.W. and Rutter,W.J. Role of the S' subsites in serine protease catalysis. Active-site mapping of rat chymotrypsin, rat trypsin, alpha-lytic protease, and cercarial protease from Schistosoma mansoni Biochemistry (12-4-1994) 33, 4251-4257. PubMed Europe PubMed

1992

[YEAR:6-3-1992]Hedstrom,L., Szilagyi,L. and Rutter,W.J. Converting trypsin to chymotrypsin: the role of surface loops Science (6-3-1992) 255, 1249-1253. PubMed Europe PubMed
Takeuchi,Y., Nonaka,T., Nakamura,K.T., Kojima,S., Miura,K. and Mitsui,Y. Crystal structure of an engineered subtilisin inhibitor complexed with bovine trypsin Proc Natl Acad Sci U S A (1992) 89, 4407-4411. PubMed Europe PubMed DOI PMC EPMC S

1990

Chow,M.M., Meyer,E.F., Jr., Bode,W., Kam,C.M., Radhakrishnan,R., Vijayalakshmi,J. and Powers,J.C. The 2.2-_ resolution x-ray crystal structure of the complex of trypsin inhibited by 4-chloro-3-ethoxy-7-guanidinoisocoumarin: a proposed model of the thrombin-inhibitor complex J Am Chem Soc (1990) 112, 7783-7789. S I
Schmitt,S., Goetschel,J.D., Rommelt,E.M. and Adler,C. One-step purification of trypsin and alpha-chymotrypsin by affinity chromatography on Eupergit-aprotinin, a novel carrier for purification of serine proteases J Chromatogr (1990) 510, 239-242. PubMed Europe PubMed DOI

1989

Bartunik,H.D., Summers,L.J. and Bartsch,H.H. Crystal structure of bovine beta-trypsin at 1.5 A resolution in a crystal form with low molecular packing density. Active site geometry, ion pairs and solvent structure J Mol Biol (1989) 210, 813-828. PubMed Europe PubMed S
Zhou,J.M., Liu,C. and Tsou,C.L. Kinetics of trypsin inhibition by its specific inhibitors Biochemistry (1989) 28, 1070-1076. PubMed Europe PubMed

1988

Graf,L., Jancso,A., Szilagyi,L., Hegyi,G., Pinter,K., Naray-Szabo,G., Hepp,J., Medzihradszky,K. and Rutter,W.J. Electrostatic complementarity within the substrate-binding pocket of trypsin Proc Natl Acad Sci U S A (1988) 85, 4961-4965. PubMed Europe PubMed PMC EPMC

1987

[YEAR:1-2-1987]Angliker,H., Wikstrom,P., Rauber,P. and Shaw,E. The synthesis of lysylfluoromethanes and their properties as inhibitors of trypsin, plasmin and cathepsin B Biochem J (1-2-1987) 241, 871-875. PubMed Europe PubMed PMC EPMC I
Fletcher,T.S., Alhadeff,M., Craik,C.S. and Largman,C. Isolation and characterization of a cDNA encoding rat cationic trypsinogen Biochemistry (1987) 26, 3081-3086. PubMed Europe PubMed

1984

Bode,W., Walter,J., Huber,R., Wenzel,H.R. and Tschesche,H. The refined 2.2-A (0.22-nm) X-ray crystal structure of the ternary complex formed by bovine trypsinogen, valine-valine and the Arg15 analogue of bovine pancreatic trypsin inhibitor Eur J Biochem (1984) 144, 185-190. PubMed Europe PubMed S
Craik,C.S., Choo,Q.L., Swift,G.H., Quinto,C., Macdonald,R.J. and Rutter,W.J. Structure of two related rat pancreatic trypsin genes J Biol Chem (1984) 259, 14255-14264. PubMed Europe PubMed
Honey,N.K., Sakaguchi,A.Y., Lalley,P.A., Quinto,C., Macdonald,R.J., Craik,C., Bell,G.I., Rutter,W.J. and Naylor,S.L. Chromosomal assignments of genes for trypsin, chymotrypsin B, and elastase in mouse Somat Cell Mol Genet (1984) 10, 377-383. PubMed Europe PubMed

1983

Malthouse,J.P.G., Mackenzie,N.E., Boyd,A.S.F. and Scott,A.I. Detection of a tetrahedral adduct in a trypsin-chloromethyl ketone specific inhibitor complex by 13C NMR J Am Chem Soc (1983) 105, 1685-1686. I
Marquart,M., Walter,J., Deisenhofer,J., Bode,W. and Huber,R. The geometry of the reactive site and of the peptide groups in trypsin, trypsinogen and its complexes with inhibitors Acta Crystallographica Section B-Structural Science (1983) 39, 480-490. DOI
Walter,J. and Bode,W. The X-ray crystal structure analysis of the refined complex formed by bovine trypsin and p-amidinophenylpyruvate at 1.4 A resolution Hoppe Seylers Z Physiol Chem (1983) 364, 949-959. PubMed Europe PubMed S

1982

[YEAR:25-12-1982]Bolognesi,M., Gatti,G., Menagatti,E., Guarneri,M., Marquart,M., Papamokos,E. and Huber,R. Three-dimensional structure of the complex between pancreatic secretory trypsin inhibitor (Kazal type) and trypsinogen at 1.8 A resolution. Structure solution, crystallographic refinement and preliminary structural interpretation J Mol Biol (25-12-1982) 162, 839-868. PubMed Europe PubMed S
[YEAR:25-8-1982]Macdonald,R.J., Stary,S.J. and Swift,G.H. Two similar but nonallelic rat pancreatic trypsinogens. Nucleotide sequences of the cloned cDNAs J Biol Chem (25-8-1982) 257, 9724-9732. PubMed Europe PubMed

1981

[YEAR:27-10-1981]Kossiakoff,A.A. and Spencer,S.A. Direct determination of the protonation states of aspartic acid-102 and histidine-57 in the tetrahedral intermediate of the serine proteases: neutron structure of trypsin Biochemistry (27-10-1981) 20, 6462-6474. PubMed Europe PubMed
McRae,B.J., Kurachi,K., Heimark,R.L., Fujikawa,K., Davie,E.W. and Powers,J.C. Mapping the active sites of bovine thrombin, factor IXa, factor Xa, factor XIa, factor XIIa, plasma kallikrein, and trypsin with amino acid and peptide thioesters: development of new sensitive substrates Biochemistry (1981) 20, 7196-7206. PubMed Europe PubMed

1979

[YEAR:5-2-1979]Bode,W. The transition of bovine trypsinogen to a trypsin-like state upon strong ligand binding. II. The binding of the pancreatic trypsin inhibitor and of isoleucine-valine and of sequentially related peptides to trypsinogen and to p-guanidinobenzoate-trypsinogen J Mol Biol (5-2-1979) 127, 357-374. PubMed Europe PubMed I

1978

Bloom,J.W. and Hunter,M.J. Interactions of alpha1-antitrypsin with trypsin and chymotrypsin J Biol Chem (1978) 253, 547-559. PubMed Europe PubMed
[YEAR:5-1-1978]Bode,W., Schwager,P. and Huber,R. The transition of bovine trypsinogen to a trypsin-like state upon strong ligand binding. The refined crystal structures of the bovine trypsinogen-pancreatic trypsin inhibitor complex and of its ternary complex with Ile-Val at 1.9 A resolution J Mol Biol (5-1-1978) 118, 99-112. PubMed Europe PubMed
[YEAR:15-6-1978]Bode,W. and Huber,R. Crystal structure analysis and refinement of two variants of trigonal trypsinogen: trigonal trypsin and PEG (polyethylene glycol) trypsinogen and their comparison with orthorhombic trypsin and trigonal trypsinogen FEBS Lett (15-6-1978) 90, 265-269. PubMed Europe PubMed DOI
DeTraglia,M.C., Brand,J.S. and Tometsko,A.M. Characterization of azidobenzamidines as photoaffinity labels for trypsin J Biol Chem (1978) 253, 1846-1852. PubMed Europe PubMed I
Huber,R. and Bode,W. Structural basis of the activation and action of trypsin Acc Chem Res (1978) 11, 114-122. S
Lively,M.O. and Powers,J.C. Specificity and reactivity of human granulocyte elastase and cathepsin G, porcine pancreatic elastase, bovine chymotrypsin and trypsin toward inhibition with sulfonyl fluorides Biochim Biophys Acta (1978) 525, 171-179. PubMed Europe PubMed I
[YEAR:31-10-1978]Porubcan,M.A., Neves,D.E., Rausch,S.K. and Markley,J.L. Active site in zymogens. Proton magnetic resonance pH titration curves of histidine-57 in porcine and bovine trypsinogens and in their complexes with bovine pancreatic trypsin inhibitor (Kunitz) Biochemistry (31-10-1978) 17, 4640-4647. PubMed Europe PubMed

1977

Fehlhammer,H., Bode,W. and Huber,R. Crystal structure of bovine trypsinogen at 1-8 A resolution. II. Crystallographic refinement, refined crystal structure and comparison with bovine trypsin J Mol Biol (1977) 111, 415-438. PubMed Europe PubMed S
Kossiakoff,A.A., Chambers,J.L., Kay,L.M. and Stroud,R.M. Structure of bovine trypsinogen at 1.9 A resolution Biochemistry (1977) 16, 654-664. PubMed Europe PubMed S
Kraut,J. Serine proteases: structure and mechanism of catalysis Annu Rev Biochem (1977) 46, 331-358. PubMed Europe PubMed DOI
[YEAR:13-10-1977]Tamura,Y., Hirado,M., Okamura,K., Minato,Y. and Fujii,S. Synthetic inhibitors of trypsin, plasmin, kallikrein, thrombin, C1r, and C1 esterase Biochim Biophys Acta (13-10-1977) 484, 417-422. PubMed Europe PubMed I

1976

Bode,W., Fehlhammer,H. and Huber,R. Crystal structure of bovine trypsinogen at 1-8 A resolution. I. Data collection, application of patterson search techniques and preliminary structural interpretation J Mol Biol (1976) 106, 325-335. PubMed Europe PubMed S
Casey,R. and Lang,A. Tryptic hydrolysis at asparagine residues in globin chains Biochim Biophys Acta (1976) 434, 184-188. PubMed Europe PubMed P
Geratz,J.D., Cheng,M.C. and Tidwell,R.R. Novel bis(benzamidino) compounds with an aromatic central link. Inhibitors of thrombin, pancreatic kallikrein, trypsin, and complement J Med Chem (1976) 19, 634-639. PubMed Europe PubMed I

1975

[YEAR:15-11-1975]Bode,W. and Schwager,P. The refined crystal structure of bovine beta-trypsin at 1.8 A resolution. II. Crystallographic refinement, calcium binding site, benzamidine binding site and active site at pH 7.0 J Mol Biol (15-11-1975) 98, 693-717. PubMed Europe PubMed S I
Fehlhammer,H. and Bode,W. The refined crystal structure of bovine beta-trypsin at 1.8 A resolution. I. Crystallization, data collection and application of patterson search technique J Mol Biol (1975) 98, 683-692. PubMed Europe PubMed S
Geratz,J.D., Mar,E.C., Loeffler,L.J. and Fox,L.B. Synthesis of isosteres of p-amidinophenylpyruvic acid. Inhibitors of trypsin, thrombin and pancreatic kallikrein J Med Chem (1975) 18, 287-292. PubMed Europe PubMed I
Harpel,P.C. and Cooper,N.R. Studies on human plasma C1 inactivator-enzyme interactions. I. Mechanisms of interaction with C1s, plasmin, and trypsin J Clin Invest (1975) 55, 593-604. PubMed Europe PubMed DOI PMC EPMC
[YEAR:30-5-1975]Huber,R., Bode,W., Kukla,D., Kohl,U. and Ryan,C.A. The structure of the complex formed by bovine trypsin and bovine pancreatic trypsin inhibitor III. Structure of the anhydro-trypsin-inhibitor complex Biophys Struct Mech (30-5-1975) 1, 189-201. PubMed Europe PubMed S
[YEAR:8-4-1975]Titani,K., Ericsson,L.H., Neurath,H. and Walsh,K.A. Amino acid sequence of dogfish trypsin Biochemistry (8-4-1975) 14, 1358-1366. PubMed Europe PubMed

1974

[YEAR:15-10-1974]Huber,R., Kukla,D., Bode,W., Schwager,P., Bartels,K., Deisenhofer,J. and Steigemann,W. Structure of the complex formed by bovine trypsin and bovine pancreatic trypsin inhibitor. II. Crystallographic refinement at 1.9 A resolution J Mol Biol (15-10-1974) 89, 73-101. PubMed Europe PubMed S
[YEAR:25-2-1974]Krieger,M., Kay,L.M. and Stroud,R.M. Structure and specific binding of trypsin: comparison of inhibited derivatives and a model for substrate binding J Mol Biol (25-2-1974) 83, 209-230. PubMed Europe PubMed I
[YEAR:24-9-1974]Sweet,R.M., Wright,H.T., Janin,J., Chothia,C.H. and Blow,D.M. Crystal structure of the complex of porcine trypsin with soybean trypsin inhibitor (Kunitz) at 2.6-A resolution Biochemistry (24-9-1974) 13, 4212-4228. PubMed Europe PubMed S

1973

Baratti,J., Maroux,S. and Louvard,D. Effect of ionic strength and calcium ions on the activation of trypsinogen by enterokinase. A modified test for the quantitative evaluation of this enzyme Biochim Biophys Acta (1973) 321, 632-638. PubMed Europe PubMed
Coats,E.A. Comparative inhibition of thrombin, plasmin, trypsin, and complement by benzamidines using substituent constants and regression analysis J Med Chem (1973) 16, 1102-1106. PubMed Europe PubMed I
Jameson,G.W., Roberts,D.V., Adams,R.W., Kyle,W.S. and Elmore,D.T. Determination of the operational molarity of solutions of bovine alpha-chymotrypsin, trypsin, thrombin and factor Xa by spectrofluorimetric titration Biochem J (1973) 131, 107-117. PubMed Europe PubMed PMC EPMC I
[YEAR:10-3-1973]Luthy,J.A., Praissman,M., Finkenstadt,W.R. and Laskowski,M., Jr. Detailed mechanism of interaction of bovine beta-trypsin with soybean trypsin inhibitor (Kunitz). I. Stopped flow measurements J Biol Chem (10-3-1973) 248, 1760-1771. PubMed Europe PubMed
Ohlsson,K. and Tegner,H. Anionic and cationic dog trypsin. Isolation and partial characterization Biochim Biophys Acta (1973) 317, 328-337. PubMed Europe PubMed
Rinderknecht,H. and Geokas,M.C. Anionic and cationic trypsinogens (trypsins) in mammalian pancreas Enzyme (1973) 14, 116-130.
Ruhlmann,A., Kukla,D., Schwager,P., Bartels,K. and Huber,R. Structure of the complex formed by bovine trypsin and bovine pancreatic trypsin inhibitor. Crystal structure determination and stereochemistry of the contact region J Mol Biol (1973) 77, 417-436. PubMed Europe PubMed S

1972

[YEAR:28-6-1972]Ako,H., Foster,R.J. and Ryan,C.A. The preparation of anhydro-trypsin and its reactivity with naturally occurring proteinase inhibitors Biochem Biophys Res Commun (28-6-1972) 47, 1402-1407. PubMed Europe PubMed
Geratz,J.D. Kinetic aspects of the irreversible inhibition of trypsin and related enzymes by p-[m(m-fluorosulfonylphenylureido)phenoxyethoxy]benzamidine FEBS Lett (1972) 20, 294-296. PubMed Europe PubMed I

1971

Keil-Dlouha V,V., Zylber,N., Imhoff,J., Tong,N. and Keil,B. Proteolytic activity of pseudotrypsin FEBS Lett (1971) 16, 291-295. PubMed Europe PubMed
Keil,B. 8. Trypsin Enzymes (1971) 3, 249-275. DOI
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1970

Feinstein,G. Purification of trypsin by affinity chromatography on ovomucoid-Sepharose resin FEBS Lett (1970) 7, 353-355. PubMed Europe PubMed
Walsh,K.A. Trypsinogens and trypsins of various species Methods Enzymol (1970) 19, 41-63. DOI V
Zahnley,J.C. and Davis,J.G. Determination of trypsin-inhibitor complex dissociation by use of the active site titrant, p-nitrophenyl p'-guanidinobenzoate Biochemistry (1970) 9, 1428-1433. PubMed Europe PubMed I

1969

Abita,J.P., Delaage,M. and Lazdunski,M. The mechanism of activation of trypsinogen. The role of the four N-terminal aspartyl residues Eur J Biochem (1969) 8, 314-324. PubMed Europe PubMed
Chase,T., Jr. and Shaw,E. Comparison of the esterase activities of trypsin, plasmin, and thrombin on guanidinobenzoate esters. Titration of the enzymes Biochemistry (1969) 8, 2212-2224. PubMed Europe PubMed DOI I
Smith,R.L. and Shaw,E. Pseudotrypsin. A modified bovine trypsin produced by limited autodigestion J Biol Chem (1969) 244, 4704-4712. PubMed Europe PubMed I

1968

Baker,B.R. and Erickson,E.H. Irreversible enzyme inhibitors. CXV. Proteolytic enzymes. V. Active-site-directed irreversible inhibitors of trypsin derived from p-(phenoxyalkoxy) benzamidines with a terminal sulfonyl fluoride J Med Chem (1968) 11, 245-249. PubMed Europe PubMed I
Elmore,D.T. and Smyth,J.J. A new method for determining the absolute molarity of solutions of trypsin and chymotrypsin by using p-nitrophenyl N2-acetyl-N1-benzylcarbazate Biochem J (1968) 107, 103-107. PubMed Europe PubMed PMC EPMC I
Elmore,D.T. and Smyth,J.J. The behaviour of trypsin towards alpha-N-methyl-alpha-N-toluene-p-sulfonyl-L-lysine beta-naphthyl ester. A new method for determining the absolute molarity of solutions of trypsin Biochem J (1968) 107, 97-102. PubMed Europe PubMed A
Tanizawa,K., Ishii,S.I. and Kanaoka,Y. Trypsin substrates derived from benzamidine: application to active site titration and isolation of acyl-enzyme intermediate Biochem Biophys Res Commun (1968) 32, 893-897. PubMed Europe PubMed I

1967

[YEAR:30-11-1967]Chase,T., Jr. and Shaw,E. p-Nitrophenyl-p'-guanidinobenzoate HCl: a new active site titrant for trypsin Biochem Biophys Res Commun (30-11-1967) 29, 508-514. PubMed Europe PubMed I
Elmore,D.T., Roberts,D.V. and Smyth,J.J. Kinetics and mechanism of catalysis by proteolytic enzymes: the kinetics of hydrolysis of derivatives of l-lysine and S-(beta-aminoethyl)-l-cysteine(thialysine)by bovine trypsin Biochem J (1967) 102, 728-734. PubMed Europe PubMed PMC EPMC
Rovery,M. [25] Chromatography of trypsin to remove chymotrypsin, and of chymotrypsin to remove trypsin Methods Enzymol (1967) 11, 231-236. DOI

1966

Bender,M.L., Begue-Canton,M.L., Blakeley,R.L., Brubacher,L.J., Feder,J., Gunter,C.R., Kezdy,F.J., Killheffer,J.V., Jr., Marshall,T.H., Miller,C.G., Roeske,R.W. and Stoops,J.K. The determination of the concentration of hydrolytic enzyme solutions: alpha-chymotrypsin, trypsin, papain, elastase, subtilisin, and acetylcholinesterase J Am Chem Soc (1966) 88, 5890-5913. PubMed Europe PubMed
[YEAR:25-11-1966]Feinstein,G. and Feeney,R.E. Interaction of inactive derivatives of chymotrypsin and trypsin with protein inhibitors J Biol Chem (25-11-1966) 241, 5183-5189. PubMed Europe PubMed

1965

Hartley,B.S., Brown,J.R., Kauffman,D.L. and Smillie,L.B. Evolutionary similarities between pancreatic proteolytic enzymes Nature (1965) 207, 1157-1159. PubMed Europe PubMed DOI
Mares-Guia,M. and Shaw,E. Studies on the active center of trypsin. The binding of amidines and guanidines as models of the substrate side chain J Biol Chem (1965) 240, 1579-1585. PubMed Europe PubMed I
Plapinger,R.E., Nachlas,M.M., Seligman,M.L. and Seligman,A.M. Synthesis of chromogenic arginine derivatives as substrates for trypsin J Org Chem (1965) 30, 1781-1785. PubMed Europe PubMed
Shaw,E., Mares-Guia,M. and Cohen,W. Evidence for an active-center histidine in trypsin through use of a specific reagent, 1-chloro-3-tosylamido-7-amino-2-heptanone, the chloromethyl ketone derived from Nalpha-tosyl-L-lysine Biochemistry (1965) 4, 2219-2224. I

1964

Walsh,K.A. and Neurath,H. Trypsinogen and chymotrypsinogen as homologous proteins Proc Natl Acad Sci U S A (1964) 52, 884-889. PubMed Europe PubMed PMC EPMC
Walsh,K.A., Kauffman,D.L., Kumar,K.S. and Neurath,H. ON THE STRUCTURE AND FUNCTION OF BOVINE TRYPSINOGEN AND TRYPSIN Proc Natl Acad Sci U S A (1964) 51, 301-308. PubMed Europe PubMed PMC EPMC

1963

Fahrney,D.E. and Gold,A.M. Sulfonyl fluorides as inhibitors of esterases. I. Rates of reaction with acetylcholinesterase, alpha-chymotrypsin, and trypsin J Am Chem Soc (1963) 85, 997-1000. DOI I
Inagami,T. and Murachi,T. Induced activation of the catalytic site of trypsin J Biol Chem (1963) 238, C1905-C1907. PubMed Europe PubMed
Roth,M. [Fluorimetric determination of trypsin] Clin Chim Acta (1963) 8, 574-578. PubMed Europe PubMed A
Trowbridge,C.G., Krehbiel,A. and Laskowski,M., Jr. Substrate activation of trypsin Biochemistry (1963) 2, 843-850. PubMed Europe PubMed
Wolf,J.P., III and Niemann,C. The alpha-chymotrypsin-catalyzed hydrolysis of a series of analogs of acetylglycine methyl ester Biochemistry (1963) 2, 493-497. PubMed Europe PubMed

1962

Allende,J.E. and Richards,F.M. The action of trypsin on ribonuclease-S Biochemistry (1962) 1, 295-304. PubMed Europe PubMed
Travis,J. and Liener,I.E. The crystallization of pork trypsin Arch Biochem Biophys (1962) 97, 218-219. PubMed Europe PubMed
[YEAR:17-12-1962]Walsh,K.A., Kauffman,D.L. and Neurath,H. Peptides isolated from tryptic and chymotryptic hydrolysates of S-sulfotrypsinogen Biochim Biophys Acta (17-12-1962) 65, 540-543. PubMed Europe PubMed

1959

Greenbaum,L.M., Hirshkowitz,A. and Shoichet,I. The activation of trypsinogen by cathepsin B J Biol Chem (1959) 234, 2885-2890. PubMed Europe PubMed
Hummel,B.C. A modified spectrophotometric determination of chymotrypsin, trypsin, and thrombin Can J Biochem Physiol (1959) 37, 1393-1399. PubMed Europe PubMed A
Riedel,A., Wunsch,E. and Hartl,A. Nalpha-Benzoyl-arginin-á-naphthylamid als Substrat zur quantitaven kolorimetrischen Bestimmung von Trypsin Hoppe Seylers Z Physiol Chem (1959) 316, 61-70. A

1958

Dixon,G.H., Kauffman,D.L. and Neurath,H. Amino acid sequence in the region of diisopropylphosphoryl binding in diisopropylphosphoryl-trypsin J Biol Chem (1958) 233, 1373-1381. PubMed Europe PubMed I
Dixon,G.H., Kauffman,D.L. and Neurath,H. Amino acid sequence in the region of di-isopropyl phosphoryl binding in dip-trypsin J Am Chem Soc (1958) 80, 1260-1261. I

1957

Green,N.M. Kinetics of the reaction between trypsin and the pancreatic trypsin inhibitor Biochem J (1957) 66, 407-415. PubMed Europe PubMed PMC EPMC

1956

Dixon,G.H. and Neurath,H. The reaction of DFP with trypsin Biochim Biophys Acta (1956) 20, 572-574. PubMed Europe PubMed I
Watson,J. Trypsin-catalyzed reactions of lysyl-lysine ethyl ester Institute of Physics Online Archive (1956) 52, 592-605.

1955

Davie,E.W. and Neurath,H. Identification of a peptide released during autocatalytic activation of trypsinogen J Biol Chem (1955) 212, 515-529. PubMed Europe PubMed
Laskowski,M. [3] Trypsinogen and trypsin Methods Enzymol (1955) 2, 26-36. DOI V
Schwert,G.W. and Takenaka,Y. A spectrophotometric determination of trypsin and chymotrypsin Biochim Biophys Acta (1955) 16, 570-575. PubMed Europe PubMed A

1954

Ram,J.S., Terminiello,L., Bier,M. and Nord,F.F. On the mechanism of enzyme action. LVII. Interaction between trypsin and ovomucoid Arch Biochem (1954) 52, 451-463. PubMed Europe PubMed

1953

Green,N.M. and Work,E. Pancreatic trypsin inhibitor. II. Reaction with trypsin Biochem J (1953) 54, 347-352. PubMed Europe PubMed PMC EPMC
Green,N.M. and Neurath,H. The effects of divalent cations on trypsin J Biol Chem (1953) 204, 379-390. PubMed Europe PubMed

1951

Sanger,F. and Tuppy,H. Amino-acid sequence in the phenylalanyl chain of insulin. 2. The investigation of peptides from enzymic hydrolysates Biochem J (1951) 49, 481-490. PubMed Europe PubMed PMC EPMC P

1950

Neurath,H. and Schwert,G.W. The mode of action of the crystalline pancreatic proteolytic enzymes Chem Rev (1950) 46, 69-153. PubMed Europe PubMed V

1948

Schwert,G.W. and Neurath,H. The specific esterase activity of trypsin J Biol Chem (1948) 172, 221-239. PubMed Europe PubMed

1947

[YEAR:20-3-1947]Kunitz,M. Isolation of a crystalline protein compound of trypsin and of soybean trypsin-inhibitor J Gen Physiol (20-3-1947) 30, 311-320. PubMed Europe PubMed DOI

1946

McDonald,M.R. and Kunitz,M. An improved method for the crystallization of trypsin J Gen Physiol (1946) 29, 155-156. PubMed Europe PubMed DOI

1941

Butler,J.A.V. The molecular kinetics of trypsin action J Am Chem Soc (1941) 63, 2971-2974.
[YEAR:20-9-1941]McDonald,M.R. and Kunitz,M. The effect of calcium and other ions on the autocatalytic formation of trypsin from trypsinogen J Gen Physiol (20-9-1941) 25, 53-73. PubMed Europe PubMed DOI

1939

Hofmann,K. and Bergmann,M. The specificity of trypsin. II J Biol Chem (1939) 130, 81-86.
[YEAR:20-3-1939]Kunitz,M. Formation of trypsin from crystalline trypsinogen by means of enterokinase J Gen Physiol (20-3-1939) 22, 429-446. PubMed Europe PubMed DOI
[YEAR:20-9-1938]Anson,M.L. The estimation of pepsin, trypsin, papain and cathepsin with hemoglobin J Gen Physiol (20-9-1938) 22, 79-89. PubMed Europe PubMed DOI A

1938

[YEAR:20-5-1938]Kunitz,M. Formation of trypsin from trypsinogen by an enzyme produced by a mold of the genus Penicillium J Gen Physiol (20-5-1938) 21, 601-620. PubMed Europe PubMed DOI

1936

Kunitz,M. and Northrop,J.H. Isolation from beef pancreas of crystalline trypsinogen, trypsin, a trypsin inhibitor, and an inhibitor-trypsin compound J Gen Physiol (1936) 19, 991-1007. PubMed Europe PubMed DOI

1935

Bergmann,M., Zervas,L. and Fruton,J.S. A synthetic peptide as substrate for tryptic proteinase Science (1935) 81, 180-180. PubMed Europe PubMed DOI

1934

[YEAR:20-3-1934]Kunitz,M. and Northrop,J.H. Inactivation of crystalline trypsin J Gen Physiol (20-3-1934) 17, 591-615. PubMed Europe PubMed DOI

1932

[YEAR:20-11-1932]Northrop,J.H. and Kunitz,M. Crystalline trypsin: III. Experimental procedure and methods of measuring activity J Gen Physiol (20-11-1932) 16, 313-321. PubMed Europe PubMed DOI
[YEAR:20-11-1932]Northrop,J.H. Crystalline trypsin: IV. Reversibility of the inactivation and denaturation of trypsin by heat J Gen Physiol (20-11-1932) 16, 323-337. PubMed Europe PubMed DOI
Northrop,J.H. and Kunitz,M. Crystalline trypsin. I. Isolation and tests of purity J Gen Physiol (1932) 16, 267-294. PubMed Europe PubMed DOI
[YEAR:20-11-1932]Northrop,J.H. and Kunitz,M. Crystalline trypsin: II. General properties J Gen Physiol (20-11-1932) 16, 295-311. PubMed Europe PubMed DOI
[YEAR:20-11-1932]Northrop,J.H. Crystalline trypsin: V. Kinetics of the digestion of proteins with crude and crystalline trypsin J Gen Physiol (20-11-1932) 16, 339-348. PubMed Europe PubMed DOI

1924

[YEAR:20-3-1924]Northrop,J.H. The kinetics of trypsin digestion: IV. The course of the reaction when both substrate and enzyme concentrations are decreasing J Gen Physiol (20-3-1924) 6, 439-452. PubMed Europe PubMed DOI
[YEAR:20-1-1924]Northrop,J.H. The kinetics of trypsin digestion: I. Experimental evidence concerning the existence of an intermediate compound J Gen Physiol (20-1-1924) 6, 239-243. PubMed Europe PubMed DOI
[YEAR:20-1-1924]Northrop,J.H. A test for diffusible ions: I. The ionic nature of trypsin J Gen Physiol (20-1-1924) 6, 337-347. PubMed Europe PubMed DOI
[YEAR:20-7-1924]Northrop,J.H. The kinetics of trypsin digestion: V. Schutz's rule J Gen Physiol (20-7-1924) 6, 723-729. PubMed Europe PubMed DOI
[YEAR:20-3-1924]Northrop,J.H. The kinetics of trypsin digestion: II. Conditions under which the reaction is monomolecular J Gen Physiol (20-3-1924) 6, 417-428. PubMed Europe PubMed DOI
[YEAR:20-3-1924]Northrop,J.H. The kinetics of trypsin digestion: III. The course of the reaction with constant substrate under conditions causing inactivation of the enzyme J Gen Physiol (20-3-1924) 6, 429-437. PubMed Europe PubMed DOI

1923

[YEAR:20-1-1923]Northrop,J.H. and Hussey,R.G. A method for the quantitative determination of trypsin and pepsin J Gen Physiol (20-1-1923) 5, 353-358. PubMed Europe PubMed DOI

1922

[YEAR:20-5-1922]Northrop,J.H. Does the kinetics of trypsin digestion depend on the formation of a compound between enzyme and substrate J Gen Physiol (20-5-1922) 4, 487-509. PubMed Europe PubMed DOI

1911

White,G.F. and Crozier,W. Comparative proteolysis experiments with trypsin J Am Chem Soc (1911) 30, 2042-2048.

1905

Hedin,S.G. Observations on the action of trypsin J Physiol (1905) 32, 468-485. PubMed Europe PubMed DOI