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Literature for peptidase S01.132: mannan-binding lectin-associated serine peptidase-3

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors

(Topics flags: S Structure, M Mutation, K Knockout, R Splicing, P Specificity, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Nakhla,M.C., Comita,J., Shapiro,A.B., Moussa,S.H., Chen,A., Eyermann,C.J., O'Donnell,J.P., Miller,A.A. and Granger,B.A.
    Small molecule inhibitors of mannan-binding lectin-associated serine Proteases-2 and-3
    Eur J Med Chem (2025) 289, 117238-117238. PubMed  Europe PubMed DOI
    2. 2024
  2. Rosbjerg,A., Plchova,T.A., Bayarri-Olmos,R., Holm,B.E., Pedersen,I.S., Skjoedt,M.O. and Garred,P.
    C1q/MASP Complexes-Hybrid Complexes of Classical and Lectin Pathway Proteins Are Found in the Circulation
    J Immunol (2024) PubMed  Europe PubMed DOI
    3. 2023
  3. Dani,R., Oroszlan,G., Martinusz,R., Farkas,B., Dobos,B., Vadas,E., Zavodszky,P., Gal,P. and Dobo,J.
    Quantification of the zymogenicity and the substrate-induced activity enhancement of complement factor D
    Front Immunol (2023) 14, 1197023-1197023. PubMed  Europe PubMed DOI  PMC  EPMC
  4. Gullipalli,D., Miwa,T., Golla,M., Sato,S., Angampalli,S. and Song,W.C.
    MASP3 Deficiency in Mice Reduces but Does Not Abrogate Alternative Pathway Complement Activity Due to Intrinsic Profactor D Activity
    J Immunol (2023) 210, 1543-1551. PubMed  Europe PubMed DOI  PMC  EPMC
  5. Sekine,H., Machida,T. and Fujita,T.
    Factor D
    Immunol Rev (2023) 313, 15-24. PubMed  Europe PubMed DOI  V
    6. 2022
  6. Dobo,J., Kocsis,A., Dani,R. and Gal,P.
    Proprotein Convertases and the Complement System
    Front Immunol (2022) 13, 958121-958121. PubMed  Europe PubMed DOI  PMC  EPMC  V
  7. Kusakari,K., Machida,T., Ishida,Y., Omori,T., Suzuki,T., Sekimata,M., Wada,I., Fujita,T. and Sekine,H.
    The complex formation of MASP-3 with pattern recognition molecules of the lectin complement pathway retains MASP-3 in the circulation
    Front Immunol (2022) 13, 907023-907023. PubMed  Europe PubMed DOI  PMC  EPMC
  8. Nagy,Z.A., Heja,D., Bencze,D., Kiss,B., Boros,E., Szakacs,D., Fodor,K., Wilmanns,M., Kocsis,A., Dobo,J., Gal,P., Harmat,V. and Pal,G.
    Synergy of protease-binding sites within the ecotin homodimer is crucial for inhibition of MASP enzymes and for blocking lectin pathway activation
    J Biol Chem (2022) 298, 101985-101985. PubMed  Europe PubMed DOI  PMC  EPMC
    9. 2021
  9. Rosbjerg,A., Wurzner,R., Garred,P. and Skjoedt,M.O.
    MASP-1 and MASP-3 Bind Directly to Aspergillus fumigatus and Promote Complement Activation and Phagocytosis
    J Innate Immun (2021) , 1-14. PubMed  Europe PubMed DOI
    10. 2020
  10. Cedzynski,M. and Swierzko,A.S.
    Components of the Lectin Pathway of Complement in Haematologic Malignancies
    Cancers (Basel) (2020) 12 PubMed  Europe PubMed DOI
  11. Fuentes-Prior,P.
    Priming of SARS-CoV-2 S protein by several membrane-bound serine proteinases could explain enhanced viral infectivity and systemic COVID-19 infection
    J Biol Chem (2020) PubMed  Europe PubMed DOI  V
  12. Gajek,G., Swierzko,A.S. and Cedzynski,M.
    Association of Polymorphisms of MASP1/3, COLEC10, and COLEC11 Genes with 3MC Syndrome
    Int J Mol Sci (2020) 21 PubMed  Europe PubMed DOI
    13. 2017
  13. Pihl,R., Jensen,L., Hansen,A.G., Thogersen,I.B., Andres,S., Dagnaes-Hansen,F., Oexle,K., Enghild,J.J. and Thiel,S.
    Analysis of factor D Isoforms in Malpuech-Michels-Mingarelli-Carnevale patients highlights the role of MASP-3 as a maturase in the alternative pathway of complement
    J Immunol (2017) PubMed  Europe PubMed DOI
    14. 2016
  14. Banda,N.K., Acharya,S., Scheinman,R.I., Mehta,G., Coulombe,M., Takahashi,M., Sekine,H., Thiel,S., Fujita,T. and Holers,V.M.
    Mannan-binding lectin-associated serine protease 1/3 cleavage of pro-factor D into factor D in vivo and attenuation of collagen antibody-induced arthritis through their targeted inhibition by RNA interference-mediated gene silencing
    J Immunol (2016) 197, 3680-3694. PubMed  Europe PubMed DOI
  15. Dobo,J., Szakacs,D., Oroszlan,G., Kortvely,E., Kiss,B., Boros,E., Szasz,R., Zavodszky,P., Gal,P. and Pal,G.
    MASP-3 is the exclusive pro-factor D activator in resting blood: the lectin and the alternative complement pathways are fundamentally linked
    Sci Rep (2016) 6, 31877-31877. PubMed  Europe PubMed DOI
  16. Dobo,J., Pal,G., Cervenak,L. and Gal,P.
    The emerging roles of mannose-binding lectin-associated serine proteases (MASPs) in the lectin pathway of complement and beyond
    Immunol Rev (2016) 274, 98-111. PubMed  Europe PubMed DOI
    17. 2014
  17. Rosbjerg,A., Munthe-Fog,L., Garred,P. and Skjoedt,M.O.
    Heterocomplex formation between MBL/ficolin/CL-11-associated serine protease-1 and -3 and MBL/ficolin/CL-11-associated protein-1
    J Immunol (2014) 192, 4352-4360. PubMed  Europe PubMed DOI
    18. 2013
  18. Fraile,J.M., Ordonez,G.R., Quiros,P.M., Astudillo,A., Galvan,J.A., Colomer,D., Lopez-Otin,C., Freije,J.M. and Puente,X.S.
    Identification of novel tumor suppressor proteases by degradome profiling of colorectal carcinomas
    Oncotarget (2013) 4, 1931-1932. PubMed  Europe PubMed
  19. Gaboriaud,C., Gupta,R.K., Martin,L., Lacroix,M., Serre,L., Teillet,F., Arlaud,G.J., Rossi,V. and Thielens,N.M.
    The serine protease domain of MASP-3: enzymatic properties and crystal structure in complex with ecotin
    PLoS ONE (2013) 8, e67962-e67962. PubMed  Europe PubMed DOI  PMC  EPMC  S
  20. Yongqing,T., Wilmann,P.G., Reeve,S.B., Coetzer,T.H., Smith,A.I., Whisstock,J.C., Pike,R.N. and Wijeyewickrema,L.C.
    The X-ray crystal structure of mannose-binding lectin-associated serine proteinase-3 reveals the structural basis for enzyme inactivity associated with the Carnevale, Mingarelli, Malpuech, and Michels (3MC) syndrome
    J Biol Chem (2013) 288, 22399-22407. PubMed  Europe PubMed DOI  M  P  S
    21. 2012
  21. Schwaeble,W.J., Lynch,N.J., Gal,P. and Zavodszky,P.
    Mannan-binding lectin-associated serine proteases
    [ISSN:978-0-12-407742-3] (2012) 3, 2857-2863. DOI
  22. Yongqing,T., Drentin,N., Duncan,R.C., Wijeyewickrema,L.C. and Pike,R.N.
    Mannose-binding lectin serine proteases and associated proteins of the lectin pathway of complement: two genes, five proteins and many functions?
    Biochim Biophys Acta (2012) 1824, 253-262. PubMed  Europe PubMed DOI  V  R
    23. 2011
  23. Banda,N.K., Takahashi,M., Takahashi,K., Stahl,G.L., Hyatt,S., Glogowska,M., Wiles,T.A., Endo,Y., Fujita,T., Michael Holers,V. and Arend,W.P.
    Mechanisms of mannose-binding lectin-associated serine proteases-1/3 activation of the alternative pathway of complement
    Mol Immunol (2011) 49, 281-289. PubMed  Europe PubMed DOI
  24. Iwaki,D., Kanno,K., Takahashi,M., Endo,Y., Matsushita,M. and Fujita,T.
    The role of mannose-binding lectin-associated serine protease-3 in activation of the alternative complement pathway
    J Immunol (2011) 187, 3751-3758. PubMed  Europe PubMed DOI
  25. Takahashi,K., Chang,W.C., Takahashi,M., Pavlov,V., Ishida,Y., La Bonte,L., Shi,L., Fujita,T., Stahl,G.L. and Van Cott,E.M.
    Mannose-binding lectin and its associated proteases (MASPs) mediate coagulation and its deficiency is a risk factor in developing complications from infection, including disseminated intravascular coagulation
    Immunobiology (2011) 216, 96-102. PubMed  Europe PubMed DOI
    26. 2010
  26. Degn,S.E., Jensen,L., Gal,P., Dobo,J., Holmvad,S.H., Jensenius,J.C. and Thiel,S.
    Biological variations of MASP-3 and MAp44, two splice products of the MASP1 gene involved in regulation of the complement system
    J Immunol Methods (2010) 361, 37-50. PubMed  Europe PubMed DOI  R
  27. Skjoedt,M.O., Hummelshoj,T., Palarasah,Y., Honore,C., Koch,C., Skjodt,K. and Garred,P.
    A novel mannose-binding lectin/ficolin-associated protein is highly expressed in heart and skeletal muscle tissues and inhibits complement activation
    J Biol Chem (2010) 285, 8234-8243. PubMed  Europe PubMed DOI  PMC  EPMC
    28. 2009
  28. Degn,S.E., Hansen,A.G., Steffensen,R., Jacobsen,C., Jensenius,J.C. and Thiel,S.
    MAp44, a human protein associated with pattern recognition molecules of the complement system and regulating the lectin pathway of complement activation
    J Immunol (2009) 183, 7371-7378. PubMed  Europe PubMed DOI
    29. 2008
  29. Takahashi,M., Iwaki,D., Kanno,K., Ishida,Y., Xiong,J., Matsushita,M., Endo,Y., Miura,S., Ishii,N., Sugamura,K. and Fujita,T.
    Mannose-Binding Lectin (MBL)-Associated Serine Protease (MASP)-1 Contributes to Activation of the Lectin Complement Pathway
    J Immunol (2008) 180, 6132-6138. PubMed  Europe PubMed  K
  30. Teillet,F., Gaboriaud,C., Lacroix,M., Martin,L., Arlaud,G.J. and Thielens,N.M.
    Crystal structure of the CUB1-EGF-CUB2 domain of human MASP-1/3 and identification of its interaction sites with mannan-binding lectin and ficolins
    J Biol Chem (2008) 283, 25715-25724. PubMed  Europe PubMed DOI  S
    31. 2007
  31. Gal,P., Barna,L., Kocsis,A. and Zavodszky,P.
    Serine proteases of the classical and lectin pathways: similarities and differences
    Immunobiology (2007) 212, 267-277. PubMed  Europe PubMed DOI  V
  32. Takahashi,M., Mori,S., Shigeta,S. and Fujita,T.
    Role of MBL-associated serine protease (MASP) on activation of the lectin complement pathway
    Adv Exp Med Biol (2007) 598, 93-104. PubMed  Europe PubMed DOI  V
  33. Weiss,G., Madsen,H.O. and Garred,P.
    A novel mannose-binding lectin-associated serine protease 1/3 gene variant
    Scand J Immunol (2007) 65, 430-434. PubMed  Europe PubMed DOI  M
    34. 2006
  34. Cortesio,C.L. and Jiang,W.
    Mannan-binding lectin-associated serine protease 3 cleaves synthetic peptides and insulin-like growth factor-binding protein 5
    Arch Biochem Biophys (2006) 449, 164-170. PubMed  Europe PubMed DOI  P
    35. 2004
  35. [YEAR:18-6-2004]Chen,C.B. and Wallis,R.
    Two mechanisms for mannose-binding protein modulation of the activity of its associated serine proteases
    J Biol Chem (18-6-2004) 279, 26058-26065. PubMed  Europe PubMed DOI
  36. Schwaeble,W.J., Stover,C. and Reid,K.B.M.
    Mannan-binding lectin-associated serine proteases
    [ISSN:0-12-079610-4] (2004) 2, 1623-1627.  V
  37. [YEAR:1-4-2004]Zundel,S., Cseh,S., Lacroix,M., Dahl,M.R., Matsushita,M., Andrieu,J.P., Schwaeble,W.J., Jensenius,J.C., Fujita,T., Arlaud,G.J. and Thielens,N.M.
    Characterization of recombinant mannan-binding lectin-associated serine protease (MASP)-3 suggests an activation mechanism different from that of MASP-1 and MASP-2
    J Immunol (1-4-2004) 172, 4342-4350. PubMed  Europe PubMed
    38. 2003
  38. [YEAR:1-5-2003]Endo,Y., Nonaka,M., Saiga,H., Kakinuma,Y., Matsushita,A., Takahashi,M., Matsushita,M. and Fujita,T.
    Origin of mannose-binding lectin-associated serine protease (MASP)-1 and MASP-3 involved in the lectin complement pathway traced back to the invertebrate, amphioxus
    J Immunol (1-5-2003) 170, 4701-4707. PubMed  Europe PubMed
  39. Presanis,J.S., Kojima,M. and Sim,R.B.
    Biochemistry and genetics of mannan-binding lectin (MBL)
    Biochem Soc Trans (2003) 31, 748-752. PubMed  Europe PubMed DOI
    40. 2002
  40. Endo,Y., Takahashi,M., Kuraya,M., Matsushita,M., Stover,C.M., Schwaeble,W.J. and Fujita,T.
    Functional characterization of human mannose-binding lectin-associated serine protease (MASP)-1/3 and MASP-2 promoters, and comparison with the C1s promoter
    Int Immunol (2002) 14, 1193-1201. PubMed  Europe PubMed
  41. Fujita,T.
    Evolution of the lectin-complement pathway and its role in innate immunity
    Nat Rev Immunol (2002) 2, 346-353. PubMed  Europe PubMed DOI
  42. Hajela,K., Kojima,M., Ambrus,G., Wong,K.H., Moffatt,B.E., Ferluga,J., Hajela,S., Gal,P. and Sim,R.B.
    The biological functions of MBL-associated serine proteases (MASPs)
    Immunobiology (2002) 205, 467-475. PubMed  Europe PubMed
  43. [YEAR:15-10-2002]Neth,O., Jack,D.L., Johnson,M., Klein,N.J. and Turner,M.W.
    Enhancement of complement activation and opsonophagocytosis by complexes of mannose-binding lectin with mannose-binding lectin-associated serine protease after binding to Staphylococcus aureus
    J Immunol (15-10-2002) 169, 4430-4436. PubMed  Europe PubMed
  44. Nonaka,M. and Miyazawa,S.
    Evolution of the initiating enzymes of the complement system
    Genome Biol (2002) 3, REVIEWS1001-REVIEWS1001. PubMed  Europe PubMed  PMC  EPMC
  45. Schwaeble,W., Dahl,M.R., Thiel,S., Stover,C. and Jensenius,J.C.
    The mannan-binding lectin-associated serine proteases (MASPs) and MAp19: four components of the lectin pathway activation complex encoded by two genes
    Immunobiology (2002) 205, 455-466. PubMed  Europe PubMed DOI  R
    46. 2001
  46. Dahl,M.R., Thiel,S., Matsushita,M., Fujita,T., Willis,A.C., Christensen,T., Vorup-Jensen,T. and Jensenius,J.C.
    MASP-3 and its association with distinct complexes of the mannan-binding lectin complement activation pathway
    Immunity (2001) 15, 127-135. PubMed  Europe PubMed DOI  R
    47. 2000
  47. Sim,R.B. and Laich,A.
    Serine proteases of the complement system
    Biochem Soc Trans (2000) 28, 545-550. PubMed  Europe PubMed

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