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Literature for peptidase S01.010: granzyme B (Homo sapiens-type)

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, I Inhibitor, L Localization, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Hu,Q.L. and Liang,S.H.
    Cyclic Peptides Targeting Granzyme B: Potential Applications as PET Imaging Agents
    ACS Med Chem Lett16, 180-181. PubMed  Europe PubMed DOI
  2. Lane,M., Aubert,A., Prudova,A., Liu,F., Russo,V., Jung,K., Khosravi-Hafshejani,T., Zhao,H., Crawford,R.I., Phillips,E. and Granville,D.J.
    Extracellular Granzyme B mediates degradation of Collagen XVII in Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis
    J Invest Dermatol PubMed  Europe PubMed DOI
  3. Maleka,M.N., Mbita,Z. and Morafo,V.
    Regulation of Granzymes A and B by High-Risk HPV: Impact on Immune Evasion and Carcinogenesis
    Viruses17, PubMed  Europe PubMed DOI  V
  4. Wei,R., Lei,L., Wu,L.L., Zhang,L. and Hu,H.Y.
    Self-Immobilizing Fluorogenic Probe for In Situ Labeling of Granzyme B Activity in Host Immune Response to Bacterial Infections
    Chembiocheme202400990-e202400990. PubMed  Europe PubMed DOI
    5. 2024
  5. Anderson,T.S., McCormick,A.L., Smith,S.L. and Lowe,D.B.
    Modeling antibody drug conjugate potential using a granzyme B antibody fusion protein
    BMC Biol22, 66-66. PubMed  Europe PubMed DOI
  6. Aubert,A., Liu,A., Kao,M., Goeres,J., Richardson,K.C., Nierves,L., Jung,K., Nabai,L., Zhao,H., Orend,G., Krawetz,R., Lange,P.F., Younger,A., Chan,J. and Granville,D.J.
    Granzyme B cleaves Tenascin-C to release its C-terminal domain in rheumatoid arthritis
    JCI Insight9, e181935-e181935. PubMed  Europe PubMed DOI
  7. Aubert,A., Goeres,J., Liu,A., Kao,M., Richardson,K.C., Jung,K., Hinz,B., Crawford,R.I. and Granville,D.J.
    Potential implications of granzyme B in keloids and hypertrophic scars through extracellular matrix remodeling and latent TGF-beta activation
    Front Immunol15, 1484462-1484462. PubMed  Europe PubMed DOI
  8. Ben-Eltriki,M., Ahmadi,A.R., Nakao,Y., Golla,K., Lakschevitz,F., Hakkinen,L., Granville,D.J. and Kim,H.
    Granzyme B promotes matrix metalloproteinase-1 (MMP-1) release from gingival fibroblasts in a PAR1- and Erk1/2-dependent manner: A novel role in periodontal inflammation
    J Periodontal Res59, 94-103. PubMed  Europe PubMed DOI
  9. Gill,K., Yoo,H.S., Chakravarthy,H., Granville,D.J. and Matsubara,J.A.
    Exploring the role of granzyme B in subretinal fibrosis of age-related macular degeneration
    Front Immunol15, 1421175-1421175. PubMed  Europe PubMed DOI  V
  10. Kellerer,M., Javed,S., Casar,C., Will,N., Berkhout,L.K., Schwinge,D., Krebs,C.F., Schramm,C., Neumann,K. and Tiegs,G.
    Antagonistic effects of the cytotoxic molecules granzyme B and TRAIL in the immunopathogenesis of sclerosing cholangitis
    Hepatology80, 844-858. PubMed  Europe PubMed DOI
  11. Li,Z., Ma,R., Tang,H., Guo,J., Shah,Z., Zhang,J., Liu,N., Cao,S., Marcucci,G., Artis,D., Caligiuri,M.A. and Yu,J.
    Therapeutic application of human type 2 innate lymphoid cells via induction of granzyme B-mediated tumor cell death
    Cell187, 624-641. PubMed  Europe PubMed DOI
  12. Mandal,M., Pires,D., Calado,M., Azevedo-Pereira,J.M. and Anes,E.
    Cystatin F Depletion in Mycobacterium tuberculosis-Infected Macrophages Improves Cathepsin C/Granzyme B-Driven Cytotoxic Effects on HIV-Infected Cells during Coinfection
    Int J Mol Sci25, PubMed  Europe PubMed DOI
  13. Obasanmi,G., Uppal,M., Cui,J.Z., Xi,J., Ju,M.J., Song,J., To,E., Li,S., Khan,W., Cheng,D., Zhu,J., Irani,L., Samad,I., Zhu,J., Yoo,H.S., Aubert,A., Stoddard,J., Neuringer,M., Granville,D.J. and Matsubara,J.A.
    Granzyme B degrades extracellular matrix and promotes inflammation and choroidal neovascularization
    Angiogenesis27, 351-373. PubMed  Europe PubMed DOI
  14. Richardson,K.C., Jung,K., Matsubara,J.A., Choy,J.C. and Granville,D.J.
    Granzyme B in aging and age-related pathologies
    Trends Mol Med30, 1165-1179. PubMed  Europe PubMed DOI  V
  15. Shi,Z., Yan,J., Zhao,M., Li,S., She,T. and Qian,X.
    Co-encapsulation of granzyme B and perforin in nanocapsules for tumour therapy: biomimicking immune cells
    J Control Release369, 658-667. PubMed  Europe PubMed DOI
  16. Thompson,R. and Cao,X.
    Reassessing granzyme B: unveiling perforin-independent versatility in immune responses and therapeutic potentials
    Front Immunol15, 1392535-1392535. PubMed  Europe PubMed DOI  V
  17. Thulin,H., Safholm,J., Lundahl,J., Jovic,V., Adner,M. and Nilsson,C.
    Granzyme B is elevated in esophageal biopsies from children with eosinophilic esophagitis
    J Pediatr Gastroenterol Nutr78, 313-319. PubMed  Europe PubMed DOI
    18. 2023
  18. Bruning,N., Bonnemann,V. and Watzl,C.
    Analyzing the activity of the proteases granzyme B and caspase-8 inside living cells using fluorescence localization reporters
    Methods Cell Biol178, 13-24. PubMed  Europe PubMed DOI
  19. Dawodu,D., Sand,S., Nikolouli,E., Werfel,T. and Mommert,S.
    The mRNA expression and secretion of granzyme B are up-regulated via the histamine H2 receptor in human CD4(+) T cells
    Inflamm Res72, 1525-1538. PubMed  Europe PubMed DOI
  20. Gao,T., Yi,L., Wang,Y., Wang,W., Zhao,Q., Song,Y., Ding,M., Deng,C., Chen,Y., Xie,Y., Wu,W., Jin,Q., Zhang,L. and Xie,M.
    Granzyme B-responsive fluorescent probe for non-invasive early diagnosis of transplant rejection
    Biosens Bioelectron232, 115303-115303. PubMed  Europe PubMed DOI
  21. Jin,Y., Gao,P., Liang,L., Wang,Y., Li,J., Wang,J., Hou,J., Yang,C. and Wang,X.
    Noninvasive quantification of granzyme B in cardiac allograft rejection using targeted ultrasound imaging
    Front Immunol14, 1164183-1164183. PubMed  Europe PubMed DOI
  22. Kazuta,N., Watanabe,H. and Ono,M.
    Synthesis and evaluation of (111) In-labeled tetrapeptide-based compounds as single-photon emission computed tomography imaging probes targeting granzyme B
    J Labelled Comp Radiopharm66, 298-307. PubMed  Europe PubMed DOI
  23. Kumagai,J., Kiuchi,M., Kokubo,K., Yagyu,H., Nemoto,M., Tsuji,K., Nagahata,K., Sasaki,A., Hishiya,T., Onoue,M., Shinmi,R., Sonobe,Y., Iinuma,T., Yonekura,S., Shinga,J., Hanazawa,T., Koseki,H., Nakayama,T., Yokote,K. and Hirahara,K.
    The USP7-STAT3-granzyme-Par-1 axis regulates allergic inflammation by promoting differentiation of IL-5-producing Th2 cells
    Proc Natl Acad Sci U S A120, e2302903120-e2302903120. PubMed  Europe PubMed DOI
  24. Li,X., Chen,G., Wu,K., Zheng,H., Tian,Z., Xu,Z., Zhao,W., Weng,J. and Min,Y.
    Imaging and monitoring of granzyme B in the immune response
    Wiley Interdiscip Rev Nanomed Nanobiotechnole1928-e1928. PubMed  Europe PubMed DOI  V
  25. Lim,Y.S., Lee,A.G., Jiang,X., Scott,J.M., Cofie,A., Kumar,S., Kennedy,D., Granville,D.J. and Shin,H.
    NK cell-derived extracellular granzyme B drives epithelial ulceration during HSV-2 genital infection
    Cell Rep42, 112410-112410. PubMed  Europe PubMed DOI
  26. Xu,C., He,S., Wei,X., Huang,J., Xu,M. and Pu,K.
    Activatable Sonoafterglow Nanoprobes for T-Cell Imaging
    Adv Mater35, e2211651-e2211651. PubMed  Europe PubMed DOI
    27. 2022
  27. Hadi,M., Akbari,A., Dehbidi,G.R., Arabsolghar,R. and Bahmani,T.
    Expression and Purification of Human Granzyme B Fusion Protein to Induce Targeted Apoptosis in PSMA Positive Prostate Cancer Cells
    Protein Pept Lett29, 631-640. PubMed  Europe PubMed DOI
  28. Jung,K., Pawluk,M.A., Lane,M., Nabai,L. and Granville,D.J.
    Granzyme B in epithelial barrier dysfunction and related skin diseases
    Am J Physiol Cell Physiol323, C170-C170. PubMed  Europe PubMed DOI  V
  29. Tibbs,E. and Cao,X.
    Emerging Canonical and Non-Canonical Roles of Granzyme B in Health and Disease
    Cancers (Basel)14, PubMed  Europe PubMed DOI  V
  30. Tripathi,N., Danger,R., Chesneau,M., Brouard,S. and Laurent,A.D.
    Structural insights into the catalytic mechanism of granzyme B upon substrate and inhibitor binding
    J Mol Graph Model114, 108167-108167. PubMed  Europe PubMed DOI
  31. Zhang,Q., Wang,Q. and Zhang,L.X.
    Granzyme B: A novel therapeutic target for treatment of atopic dermatitis
    Indian J Dermatol Venereol Leprol1-4. PubMed  Europe PubMed DOI  V
    32. 2021
  32. Burgener,S.S., Brugger,M., Leborgne,N.G.F., Sollberger,S., Basilico,P., Kaufmann,T., Bird,P.I. and Benarafa,C.
    Granule Leakage Induces Cell-Intrinsic, Granzyme B-Mediated Apoptosis in Mast Cells
    Front Cell Dev Biol9, 630166-630166. PubMed  Europe PubMed DOI
  33. Hiroyasu,S., Zeglinski,M.R., Zhao,H., Pawluk,M.A., Turner,C.T., Kasprick,A., Tateishi,C., Nishie,W., Burleigh,A., Lennox,P.A., Van Laeken,N., Carr,N.J., Petersen,F., Crawford,R.I., Shimizu,H., Tsuruta,D., Ludwig,R.J. and Granville,D.J.
    Granzyme B inhibition reduces disease severity in autoimmune blistering diseases
    Nat Commun12, 302-302. PubMed  Europe PubMed DOI
  34. Shi,H., Gong,Y., Liang,Q., Li,J., Xiang,Y. and Li,G.
    Target-Initiated Great Change in Electrochemical Steric Hindrance for an Assay of Granzyme B Activity
    Anal Chem93, 13382-13388. PubMed  Europe PubMed DOI
    35. 2020
  35. Alvarez de Cienfuegos,A., Cheung,L.H., Mohamedali,K.A., Whitsett,T.G., Winkles,J.A., Hittlerman,W.N. and Rosenblum,M.G.
    Therapeutic efficacy and safety of a human fusion construct targeting the TWEAK receptor Fn14 and containing a modified granzyme B
    J Immunother Cancer8, PubMed  Europe PubMed DOI
  36. Bou-Dargham,M.J. and Sang,Q.A.
    Secretome analysis reveals upregulated granzyme B in human androgen-repressed prostate cancer cells with mesenchymal and invasive phenotype
    PLoS ONE15, e0237222-e0237222. PubMed  Europe PubMed DOI  K
  37. Briones,J.C., Espulgar,W.V., Koyama,S., Yoshikawa,H., Park,J., Naito,Y., Kumanogoh,A., Tamiya,E., Takamatsu,H. and Saito,M.
    A microfluidic platform for single cell fluorometric granzyme B profiling
    Theranostics10, 123-132. PubMed  Europe PubMed DOI  L
  38. Capaccione,K.M., Doubrovin,M., Bhatt,N., Mintz,A. and Molotkov,A.
    Granzyme B PET Imaging of the Innate Immune Response
    Molecules25, PubMed  Europe PubMed DOI
  39. Fu,Z., Akula,S., Thorpe,M. and Hellman,L.
    Extended cleavage specificities of two mast cell chymase-related proteases and one granzyme B-like protease from the platypus, a monotreme
    Int J Mol Sci21, PubMed  Europe PubMed DOI
  40. Holt,B.A. and Kwong,G.A.
    Protease circuits for processing biological information
    Nat Commun11, 5021-5021. PubMed  Europe PubMed DOI
  41. Islimye Taskin,M., Guney,G., Adali,E., Hismiogullari,A.A., Dodurga,Y. and Elmas,L.
    Granzyme B levels and granzyme B polymorphisms in peripheral blood of patients with endometriosis: a preliminary study
    J Obstet Gynaecol1-6. PubMed  Europe PubMed DOI  V
  42. Jensen,C., Sinkeviciute,D., Madsen,D.H., Onnerfjord,P., Hansen,M., Schmidt,H., Karsdal,M.A., Svane,I.M. and Willumsen,N.
    Granzyme B Degraded Type IV Collagen Products in Serum Identify Melanoma Patients Responding to Immune Checkpoint Blockade
    Cancers (Basel)12, PubMed  Europe PubMed DOI
  43. Matsubara,J.A., Tian,Y., Cui,J.Z., Zeglinski,M.R., Hiroyasu,S., Turner,C.T. and Granville,D.J.
    Retinal distribution and extracellular activity of granzyme B: a serine protease that degrades retinal pigment epithelial tight junctions and extracellular matrix proteins
    Front Immunol11, 574-574. PubMed  Europe PubMed DOI
  44. Parra,M., Weitner,M., Yang,A., Akue,A., Liu,X., Schmidt,T., Allman,W.R., Akkoyunlu,M. and Derrick,S.C.
    Memory CD73+IgM+ B cells protect against Plasmodium yoelii infection and express Granzyme B
    PLoS ONE15, e0238493-e0238493. PubMed  Europe PubMed DOI
  45. Prunk,M., Perisic Nanut,M., Jakos,T., Sabotic,J., Svajger,U. and Kos,J.
    Extracellular Cystatin F Is Internalised by Cytotoxic T Lymphocytes and Decreases Their Cytotoxicity
    Cancers (Basel)12, PubMed  Europe PubMed DOI
    46. 2019
  46. Chaves-Pozo,E., Valero,Y., Lozano,M.T., Rodriguez-Cerezo,P., Miao,L., Campo,V., Esteban,M.A. and Cuesta,A.
    Fish granzyme A shows a greater role than granzyme B in fish innate cell-mediated cytotoxicity
    Front Immunol10, 2579-2579. PubMed  Europe PubMed DOI
  47. Gerada,C., Steain,M., Campbell,T.M., McSharry,B., Slobedman,B. and Abendroth,A.
    Granzyme B cleaves multiple HSV-1 and VZV gene products and VZV ORF4 inhibits Natural Killer cell dependent cytotoxicity
    J Virol93, e01140-19-e01140-19. PubMed  Europe PubMed DOI
  48. Mac,Q.D., Mathews,D.V., Kahla,J.A., Stoffers,C.M., Delmas,O.M., Holt,B.A., Adams,A.B. and Kwong,G.A.
    Non-invasive early detection of acute transplant rejection via nanosensors of granzyme B activity
    Nat Biomed Eng3, 281-291. PubMed  Europe PubMed DOI  A
  49. Turner,C.T., Hiroyasu,S. and Granville,D.J.
    Granzyme B as a therapeutic target for wound healing
    Expert Opin Ther Targets23, 745-754. PubMed  Europe PubMed DOI
  50. Turner,C.T., Lim,D. and Granville,D.J.
    Granzyme B in skin inflammation and disease
    Matrix Biol75-76, 126-140. PubMed  Europe PubMed DOI
    51. 2018
  51. Du,W., Mohammadpour,H., O'Neill,R.E., Kumar,S., Chen,C., Qiu,M., Mei,L., Qiu,J., McCarthy,P.L., Lee,K.P. and Cao,X.
    Serine protease inhibitor 6 protects alloreactive T cells from granzyme B-mediated mitochondrial damage without affecting graft-versus-tumor effect
    Oncoimmunology7, e1397247-e1397247. PubMed  Europe PubMed DOI
  52. Liesche,C., Sauer,P., Prager,I., Urlaub,D., Claus,M., Eils,R., Beaudouin,J. and Watzl,C.
    Single-fluorescent protein reporters allow parallel quantification of natural killer cell-mediated granzyme and caspase activities in single target cells
    Front Immunol9, 1840-1840. PubMed  Europe PubMed DOI  L
  53. Russo,V., Klein,T., Lim,D.J., Solis,N., Machado,Y., Hiroyasu,S., Nabai,L., Shen,Y., Zeglinski,M.R., Zhao,H., Oram,C.P., Lennox,P.A., Van Laeken,N., Carr,N.J., Crawford,R.I., Franzke,C.W., Overall,C.M. and Granville,D.J.
    Granzyme B is elevated in autoimmune blistering diseases and cleaves key anchoring proteins of the dermal-epidermal junction
    Sci Rep8, 9690-9690. PubMed  Europe PubMed DOI
  54. Saito,A., Okiyama,N., Kubota,N., Nakamura,Y., Fujisawa,Y., Watanabe,R., Ishitsuka,Y., Bleackley,R.C. and Fujimoto,M.
    Blockade of granzyme B remarkably improves mucocutaneous diseases with keratinocyte death in interface dermatitis
    J Invest Dermatol138, 2079-2083. PubMed  Europe PubMed DOI
    55. 2017
  55. Darrah,E., Kim,A., Zhang,X., Boronina,T., Cole,R.N., Fava,A., Giles,J.T., Iii,C.O., Chalmers,M.J., Griffin,P.R., Sadegh-Nasseri,S. and Rosen,A.
    Proteolysis by granzyme B enhances presentation of autoantigenic peptidylarginine deiminase 4 epitopes in rheumatoid arthritis
    J Proteome Res16, 355-365. PubMed  Europe PubMed DOI
  56. Dotiwala,F., Sen Santara,S., Binker-Cosen,A.A., Li,B., Chandrasekaran,S. and Lieberman,J.
    Granzyme B disrupts central metabolism and protein synthesis in bacteria to promote an immune cell death program
    Cell171, 1125-1137. PubMed  Europe PubMed DOI
  57. Hofer,U.
    Host response: granzyme B's roundhouse kick against bacteria
    Nat Rev Microbiol15, 707-707. PubMed  Europe PubMed DOI
  58. Larimer,B.M., Wehrenberg-Klee,E., Dubois,F., Mehta,A., Kalomeris,T., Flaherty,K., Boland,G. and Mahmood,U.
    Granzyme B PET imaging as a predictive biomarker of immunotherapy response
    Cancer Res77, 2318-2327. PubMed  Europe PubMed DOI  L
  59. Lee,P.R., Johnson,T.P., Gnanapavan,S., Giovannoni,G., Wang,T., Steiner,J.P., Medynets,M., Vaal,M.J., Gartner,V. and Nath,A.
    Protease-activated receptor-1 activation by granzyme B causes neurotoxicity that is augmented by interleukin-1beta
    J Neuroinflammation14, 131-131. PubMed  Europe PubMed DOI
    60. 2016
  60. Merkulova,Y., Shen,Y., Parkinson,L.G., Raithatha,S.A., Zhao,H., Westendorf,K., Sharma,M., Bleackley,R.C. and Granville,D.J.
    Granzyme B inhibits keratinocyte migration by disrupting epidermal growth factor receptor (EGFR)-mediated signaling
    Biol Chem397, 883-895. PubMed  Europe PubMed DOI
  61. Niesen,J., Hehmann-Titt,G., Woitok,M., Fendel,R., Barth,S., Fischer,R. and Stein,C.
    A novel fully-human cytolytic fusion protein based on granzyme B shows in vitro cytotoxicity and ex vivo binding to solid tumors overexpressing the epidermal growth factor receptor
    Cancer Lett374, 229-240. PubMed  Europe PubMed DOI  U
  62. Shen,Y., Cheng,F., Sharma,M., Merkulova,Y., Raithatha,S.A., Parkinson,L.G., Zhao,H., Westendorf,K., Bohunek,L., Bozin,T., Hsu,I., Ang,L.S., Williams,S.J., Bleackley,R.C., Eriksson,J.E., Seidman,M.A., McManus,B.M. and Granville,D.J.
    Granzyme B deficiency protects against angiotensin II-induced cardiac fibrosis
    Am J Pathol186, 87-100. PubMed  Europe PubMed DOI  K
    63. 2015
  63. Azzi,J., Ohori,S., Ting,C., Uehara,M., Abdoli,R., Smith,B.D., Safa,K., Solhjou,Z., Lukyanchykov,P., Patel,J., McGrath,M. and Abdi,R.
    Serine protease inhibitor-6 differentially affects the survival of effector and memory alloreactive CD8-T cells
    Am J Transplant15, 234-241. PubMed  Europe PubMed DOI
  64. Dotiwala,F., Fellay,I., Filgueira,L., Martinvalet,D., Lieberman,J. and Walch,M.
    A high yield and cost-efficient expression system of human granzymes in mammalian cells
    J Vis Expe52911-e52911. PubMed  Europe PubMed DOI  E
  65. Kapelski,S., de Almeida,M., Fischer,R., Barth,S. and Fendel,R.
    Antimalarial activity of granzyme B and its targeted delivery by a granzyme B-single-chain fv fusion protein
    Antimicrob Agents Chemother59, 669-672. PubMed  Europe PubMed DOI
  66. Konishi,M., Erdem,S.S., Weissleder,R., Lichtman,A.H., McCarthy,J.R. and Libby,P.
    Imaging granzyme B activity assesses immune-mediated myocarditis
    Circ Res117, 502-512. PubMed  Europe PubMed DOI  L
  67. Marcet-Palacios,M., Ewen,C., Pittman,E., Duggan,B., Carmine-Simmen,K., Fahlman,R.P. and Bleackley,R.C.
    Design and characterization of a novel human granzyme B inhibitor
    Protein Eng Des Sel28, 9-17. PubMed  Europe PubMed DOI
    68. 2014
  68. Hagn,M., Sutton,V.R. and Trapani,J.A.
    A colorimetric assay that specifically measures granzyme B proteolytic activity: hydrolysis of Boc-Ala-Ala-Asp-S-Bzl
    J Vis Expe52419-e52419. PubMed  Europe PubMed DOI  A  P
  69. Kim,M.S., Buisson,L.A., Heathcote,D.A., Hu,H., Braddock,D.C., Barrett,A.G., Ashton-Rickardt,P.G. and Snyder,J.P.
    Approaches to design non-covalent inhibitors for human granzyme B (hGrB)
    Org Biomol Chem12, 8952-8965. PubMed  Europe PubMed DOI  I
  70. Mhaidat,N.M., Al-Azzam,S.I., Alzoubi,K.H., Khabour,O.F. and Gharaibeh,B.F.
    Granzyme B gene polymorphisms, colorectal cancer risk, and metastasis
    J Cancer Res Ther10, 587-590. PubMed  Europe PubMed DOI  M
  71. Plasman,K., Maurer-Stroh,S., Gevaert,K. and Van Damme,P.
    Holistic view on the extended substrate specificities of orthologous granzymes
    J Proteome Res13, 1785-1793. PubMed  Europe PubMed DOI  P
  72. Salvesen,G.S.
    Dying from within: granzyme B converts entosis to emperitosis
    Cell Death Differ21, 3-4. PubMed  Europe PubMed DOI
  73. Vahedi,F., Fraleigh,N., Vlasschaert,C., McElhaney,J. and Hanifi-Moghaddam,P.
    Human granzymes: related but far apart
    Med Hypotheses83, 688-693. PubMed  Europe PubMed DOI  V
  74. Van Damme,P., Plasman,K., Vandemoortele,G., Jonckheere,V., Maurer-Stroh,S. and Gevaert,K.
    Importance of extended protease substrate recognition motifs in steering BNIP-2 cleavage by human and mouse granzymes B
    BMC Biochem15, 21-21. PubMed  Europe PubMed DOI  P
  75. Yentur,S.P., Aydin,H.N., Gurses,C., Demirbilek,V., Kuru,U., Uysal,S., Yapici,Z., Baris,S., Yilmaz,G., Cokar,O., Onal,E., Gokyigit,A. and Saruhan-Direskeneli,G.
    Granzyme B gene polymorphism associated with subacute sclerosing panencephalitis
    Neuropediatrics45, 309-313. PubMed  Europe PubMed DOI  M
  76. Zhou,H., Mohamedali,K.A., Gonzalez-Angulo,A.M., Cao,Y., Migliorini,M., Cheung,L.H., LoBello,J., Lei,X., Qi,Y., Hittelman,W.N., Winkles,J.A., Tran,N.L. and Rosenblum,M.G.
    Development of human serine protease-based therapeutics targeting Fn14 and identification of Fn14 as a new target overexpressed in TNBC
    Mol Cancer Ther13, 2688-2705. PubMed  Europe PubMed DOI  U
    77. 2013
  77. Cao,Y., Mohamedali,K.A., Marks,J.W., Cheung,L.H., Hittelman,W.N. and Rosenblum,M.G.
    Construction and characterization of novel, completely human serine protease therapeutics targeting Her2/neu
    Mol Cancer Ther12, 979-991. PubMed  Europe PubMed DOI  U
  78. Ferrara,T.M., Jin,Y., Gowan,K., Fain,P.R. and Spritz,R.A.
    Risk of generalized vitiligo is associated with the common 55R-94A-247H variant haplotype of GZMB (encoding granzyme B)
    J Invest Dermatol133, 1677-1679. PubMed  Europe PubMed DOI  M
  79. Hendel,A. and Granville,D.J.
    Granzyme B cleavage of fibronectin disrupts endothelial cell adhesion, migration and capillary tube formation
    Matrix Biol32, 14-22. PubMed  Europe PubMed DOI  I
  80. Knevel,R., Krabben,A., Wilson,A.G., Brouwer,E., Leijsma,M.K., Lindqvist,E., de Rooy,D.P., Daha,N.A., van der Linden,M.P., Tsonaka,S., Zhernakova,A., Westra,H.J., Franke,L., Houwing-Duistermaat,J.J., Toes,R.E., Huizinga,T.W., Saxne,T. and van der Helm-van Mil
    A genetic variant in granzyme B is associated with progression of joint destruction in rheumatoid arthritis
    Arthritis Rheum65, 582-589. PubMed  Europe PubMed DOI
  81. Oberoi,P., Jabulowsky,R.A., Bahr-Mahmud,H. and Wels,W.S.
    EGFR-targeted granzyme B expressed in NK cells enhances natural cytotoxicity and mediates specific killing of tumor cells
    PLoS ONE8, e61267-e61267. PubMed  Europe PubMed DOI  U
    82. 2012
  82. Boivin,W.A., Shackleford,M., Vanden Hoek,A., Zhao,H., Hackett,T.L., Knight,D.A. and Granville,D.J.
    Granzyme B cleaves decorin, biglycan and soluble betaglycan, releasing active transforming growth factor-beta1
    PLoS ONE7, e33163-e33163. PubMed  Europe PubMed DOI  P
  83. Froelich,C.J.
    Granzyme B
    [ISSN:978-0-12-407742-3]3, 2718-2721. DOI
  84. Hagn,M. and Jahrsdorfer,B.
    Why do human B cells secrete granzyme B? Insights into a novel B-cell differentiation pathway
    Oncoimmunology1, 1368-1375. PubMed  Europe PubMed DOI
  85. Hagn,M., Belz,G.T., Kallies,A., Sutton,V.R., Thia,K.Y., Tarlinton,D.M., Hawkins,E.D. and Trapani,J.A.
    Activated mouse B cells lack expression of granzyme B
    J Immunol188, 3886-3892. PubMed  Europe PubMed DOI
  86. Hiebert,P.R. and Granville,D.J.
    Granzyme B in injury, inflammation, and repair
    Trends Mol Med18, 732-741. PubMed  Europe PubMed DOI
  87. Losasso,V., Schiffer,S., Barth,S. and Carloni,P.
    Design of human granzyme B variants resistant to serpin B9
    Proteins80, 2514-2522. PubMed  Europe PubMed DOI
  88. Perl,M., Denk,S., Kalbitz,M. and Huber-Lang,M.
    Granzyme B: a new crossroad of complement and apoptosis
    Adv Exp Med Biol946, 135-146. PubMed  Europe PubMed DOI
  89. Ray,M., Hostetter,D.R., Loeb,C.R., Simko,J. and Craik,C.S.
    Inhibition of Granzyme B by PI-9 protects prostate cancer cells from apoptosis
    Prostate72, 846-855. PubMed  Europe PubMed DOI
  90. Stewart,S.E., Mangan,M.S., Bird,P.I. and Kaiserman,D.
    Detection of human and mouse granzyme B activity in cell extracts
    Methods Mol Biol844, 251-260. PubMed  Europe PubMed DOI  A
    91. 2011
  91. Afonina,I.S., Tynan,G.A., Logue,S.E., Cullen,S.P., Bots,M., Luthi,A.U., Reeves,E.P., McElvaney,N.G., Medema,J.P., Lavelle,E.C. and Martin,S.J.
    Granzyme B-dependent proteolysis acts as a switch to enhance the proinflammatory activity of IL-1alpha
    Mol Cell44, 265-278. PubMed  Europe PubMed DOI
  92. Chaitanya,G.V., Eeka,P., Munker,R., Alexander,J.S. and Babu,P.P.
    Role of cytotoxic protease granzyme-B in neuronal degeneration during human stroke
    Brain Pathol21, 16-30. PubMed  Europe PubMed DOI
  93. Espinoza,L.J., Takami,A., Nakata,K., Yamada,K., Onizuka,M., Kawase,T., Sao,H., Akiyama,H., Miyamura,K., Okamoto,S., Inoue,M., Fukuda,T., Morishima,Y., Kodera,Y. and Nakao,S.
    Genetic variants of human granzyme B predict transplant outcomes after HLA matched unrelated bone marrow transplantation for myeloid malignancies
    PLoS ONE6, e23827-e23827. PubMed  Europe PubMed DOI  M
  94. Gehrmann,M., Doss,B.T., Wagner,M., Zettlitz,K.A., Kontermann,R.E., Foulds,G., Pockley,A.G. and Multhoff,G.
    A novel expression and purification system for the production of enzymatic and biologically active human granzyme B
    J Immunol Methods371, 8-17. PubMed  Europe PubMed DOI  E
  95. Haile,Y., Simmen,K.C., Pasichnyk,D., Touret,N., Simmen,T., Lu,J.Q., Bleackley,R.C. and Giuliani,F.
    Granule-derived granzyme B mediates the vulnerability of human neurons to T cell-induced neurotoxicity
    J Immunol187, 4861-4872. PubMed  Europe PubMed DOI
  96. Kanatani,I., Lin,X., Yuan,X., Manorek,G., Shang,X., Cheung,L.H., Rosenblum,M.G. and Howell,S.B.
    Targeting granzyme B to tumor cells using a yoked human chorionic gonadotropin
    Cancer Chemother Pharmacol68, 979-990. PubMed  Europe PubMed DOI  U
  97. Marcet-Palacios,M., Duggan,B.L., Shostak,I., Barry,M., Geskes,T., Wilkins,J.A., Yanagiya,A., Sonenberg,N. and Bleackley,R.C.
    Granzyme B inhibits vaccinia virus production through proteolytic cleavage of eukaryotic initiation factor 4 gamma 3
    PLoS Pathog7, e1002447-e1002447. PubMed  Europe PubMed DOI
  98. van Tetering,G., Bovenschen,N., Meeldijk,J., van Diest,P.J. and Vooijs,M.
    Cleavage of Notch1 by granzyme B disables its transcriptional activity
    Biochem J437, 313-322. PubMed  Europe PubMed DOI  P
    99. 2010
  99. Afonina,I.S., Cullen,S.P. and Martin,S.J.
    Cytotoxic and non-cytotoxic roles of the CTL/NK protease granzyme B
    Immunol Rev235, 105-116. PubMed  Europe PubMed DOI  V
  100. Aguilo,J.I., Anel,A., Catalan,E., Sebastian,A., Acin-Perez,R., Naval,J., Wallich,R., Simon,M.M. and Pardo,J.
    Granzyme B of cytotoxic T cells induces extramitochondrial reactive oxygen species production via caspase-dependent NADPH oxidase activation
    Immunol Cell Biol88, 545-554. PubMed  Europe PubMed DOI
  101. Christensen,M.E. and Waterhouse,N.J.
    Mechanisms of CTL cytotoxicity. A reactive response to granzyme B
    Immunol Cell Biol88, 500-501. PubMed  Europe PubMed DOI  V
  102. Darrah,E. and Rosen,A.
    Granzyme B cleavage of autoantigens in autoimmunity
    Cell Death Differ17, 624-632. PubMed  Europe PubMed DOI
  103. Kurschus,F.C. and Jenne,D.E.
    Delivery and therapeutic potential of human granzyme B
    Immunol Rev235, 159-171. PubMed  Europe PubMed DOI  V  U
  104. Niland,B., Miklossy,G., Banki,K., Biddison,W.E., Casciola-Rosen,L., Rosen,A., Martinvalet,D., Lieberman,J. and Perl,A.
    Cleavage of transaldolase by granzyme B causes the loss of enzymatic activity with retention of antigenicity for multiple sclerosis patients
    J Immunol184, 4025-4032. PubMed  Europe PubMed DOI  P
  105. Omoto,Y., Yamanaka,K., Tokime,K., Kitano,S., Kakeda,M., Akeda,T., Kurokawa,I., Gabazza,E.C., Tsutsui,H., Katayama,N., Yamanishi,K., Nakanishi,K. and Mizutani,H.
    Granzyme B is a novel interleukin-18 converting enzyme
    J Dermatol Sci59, 129-135. PubMed  Europe PubMed DOI  P
  106. Rousalova,I. and Krepela,E.
    Granzyme B-induced apoptosis in cancer cells and its regulation (review)
    Int J Oncol37, 1361-1378. PubMed  Europe PubMed DOI  V
  107. Van Damme,P., Staes,A., Bronsoms,S., Helsens,K., Colaert,N., Timmerman,E., Aviles,F.X., Vandekerckhove,J. and Gevaert,K.
    Complementary positional proteomics for screening substrates of endo- and exoproteases
    Nat Methods7, 512-515. PubMed  Europe PubMed DOI  P
    108. 2009
  108. Boivin,W.A., Cooper,D.M., Hiebert,P.R. and Granville,D.J.
    Intracellular versus extracellular granzyme B in immunity and disease: challenging the dogma
    Lab Invest89, 1195-1220. PubMed  Europe PubMed DOI  V
  109. Girnita,D.M., Webber,S.A., Brooks,M.M., Ferrell,R., Girnita,A.L., Burckart,G.J., Chinnock,R., Canter,C., Addonizio,L., Bernstein,D., Kirklin,J.K., Naftel,D. and Zeevi,A.
    Genotypic variation and phenotypic characterization of granzyme B gene polymorphisms
    Transplantation87, 1801-1806. PubMed  Europe PubMed DOI  M
  110. Prakash,M.D., Bird,C.H. and Bird,P.I.
    Active and zymogen forms of granzyme B are constitutively released from cytotoxic lymphocytes in the absence of target cell engagement
    Immunol Cell Biol87, 249-254. PubMed  Europe PubMed DOI
  111. Rosenblum,M.G. and Barth,S.
    Development of novel, highly cytotoxic fusion constructs containing granzyme B: unique mechanisms and functions
    Curr Pharm Des15, 2676-2692. PubMed  Europe PubMed DOI  U
  112. Van Damme,P., Maurer-Stroh,S., Plasman,K., Van Durme,J., Colaert,N., Timmerman,E., De Bock,P.J., Goethals,M., Rousseau,F., Schymkowitz,J., Vandekerckhove,J. and Gevaert,K.
    Analysis of protein processing by N-terminal proteomics reveals novel species-specific substrate determinants of granzyme B orthologs
    Mol Cell Proteomics8, 258-272. PubMed  Europe PubMed DOI  P
    113. 2008
  113. Besenicar,M.P., Metkar,S., Wang,B., Froelich,C.J. and Anderluh,G.
    Granzyme B translocates across the lipid membrane only in the presence of lytic agents
    Biochem Biophys Res Commun371, 391-394. PubMed  Europe PubMed DOI
  114. Buzza,M.S., Dyson,J.M., Choi,H., Gardiner,E.E., Andrews,R.K., Kaiserman,D., Mitchell,C.A., Berndt,M.C., Dong,J.F. and Bird,P.I.
    Antihemostatic activity of human granzyme B mediated by cleavage of von Willebrand factor
    J Biol Chem283, 22498-22504. PubMed  Europe PubMed DOI
  115. Casciola-Rosen,L., Miagkov,A., Nagaraju,K., Askin,F., Jacobson,L., Rosen,A. and Drachman,D.B.
    Granzyme B: evidence for a role in the origin of myasthenia gravis
    J Neuroimmunol201-202, 33-40. PubMed  Europe PubMed DOI
  116. Chowdhury,D. and Lieberman,J.
    Death by a thousand cuts: granzyme pathways of programmed cell death
    Annu Rev Immunol26, 389-420. PubMed  Europe PubMed DOI  V
  117. Pardo,J., Wallich,R., Martin,P., Urban,C., Rongvaux,A., Flavell,R.A., Mullbacher,A., Borner,C. and Simon,M.M.
    Granzyme B-induced cell death exerted by ex vivo CTL: discriminating requirements for cell death and some of its signs
    Cell Death Differ15, 567-579. PubMed  Europe PubMed DOI
  118. Stahnke,B., Thepen,T., Stocker,M., Rosinke,R., Jost,E., Fischer,R., Tur,M.K. and Barth,S.
    Granzyme B-H22(scFv), a human immunotoxin targeting CD64 in acute myeloid leukemia of monocytic subtypes
    Mol Cancer Ther7, 2924-2932. PubMed  Europe PubMed DOI  U
  119. Tsuru,R., Kondo,H., Hojo,Y., Gama,M., Mizuno,O., Katsuki,T., Shimada,K., Kikuchi,M. and Yashiro,T.
    Increased granzyme B production from peripheral blood mononuclear cells in patients with acute coronary syndrome
    Heart94, 305-310. PubMed  Europe PubMed DOI
    120. 2007
  120. Casciola-Rosen,L., Garcia-Calvo,M., Bull,H.G., Becker,J.W., Hines,T., Thornberry,N.A. and Rosen,A.
    Mouse and human granzyme B have distinct tetrapeptide specificities and abilities to recruit the Bid pathway
    J Biol Chem282, 4545-4552. PubMed  Europe PubMed DOI  P
  121. Chamberlain,C.M. and Granville,D.J.
    The role of granzyme B in atheromatous diseases
    Can J Physiol Pharmacol85, 89-95. PubMed  Europe PubMed DOI
  122. [YEAR:12-2-2007]Cullen,S.P., Adrain,C., Luthi,A.U., Duriez,P.J. and Martin,S.J.
    Human and murine granzyme B exhibit divergent substrate preferences
    J Cell Biol176, 435-444. PubMed  Europe PubMed DOI  P
  123. Hostetter,D.R., Loeb,C.R., Chu,F. and Craik,C.S.
    Hip is a pro-survival substrate of granzyme B
    J Biol Chem282, 27865-27874. PubMed  Europe PubMed DOI  P
  124. Nowacki,T.M., Kuerten,S., Zhang,W., Shive,C.L., Kreher,C.R., Boehm,B.O., Lehmann,P.V. and Tary-Lehmann,M.
    Granzyme B production distinguishes recently activated CD8(+) memory cells from resting memory cells
    Cell Immunol247, 36-48. PubMed  Europe PubMed DOI
  125. Packard,B.Z., Telford,W.G., Komoriya,A. and Henkart,P.A.
    Granzyme B activity in target cells detects attack by cytotoxic lymphocytes
    J Immunol179, 3812-3820. PubMed  Europe PubMed  L
  126. Strik,M.C., de Koning,P.J., Kleijmeer,M.J., Bladergroen,B.A., Wolbink,A.M., Griffith,J.M., Wouters,D., Fukuoka,Y., Schwartz,L.B., Hack,C.E., van Ham,S.M. and Kummer,J.A.
    Human mast cells produce and release the cytotoxic lymphocyte associated protease granzyme B upon activation
    Mol Immunol44, 3462-3472. PubMed  Europe PubMed DOI
  127. Wu,X.L., Zhang,C.T. and Liu,C.Y.
    Expression and antigenecity of human granzyme B
    Chin J Biologicals20, 807-810.  E
    128. 2006
  128. [YEAR:27-9-2006]Bredemeyer,A.J., Carrigan,P.E., Fehniger,T.A., Smith,D.F. and Ley,T.J.
    Hop cleavage and function in granzyme B-induced apoptosis
    J Biol Chem281, 37130-37141. PubMed  Europe PubMed DOI
  129. [YEAR:9-12-2006]Giesubel,U., Dalken,B., Mahmud,H. and Wels,W.S.
    Cell binding, internalization and cytotoxic activity of human granzyme B expressed in the yeast Pichia pastoris
    Biochem J394, 563-573. PubMed  Europe PubMed DOI  E
  130. [YEAR:1-4-2006]Huang,C., Bi,E., Hu,Y., Deng,W., Tian,Z., Dong,C., Hu,Y. and Sun,B.
    A novel NF-kappaB binding site controls human granzyme B gene transcription
    J Immunol176, 4173-4181. PubMed  Europe PubMed
  131. Leavy,O.
    Death by granzyme B
    Nat Rev Immunol6, 709-709. DOI
  132. [YEAR:23-6-2006]Loeb,C.R., Harris,J.L. and Craik,C.S.
    Granzyme B proteolyzes receptors important to proliferation and survival, tipping the balance toward apoptosis
    J Biol Chem281, 28326-28335. PubMed  Europe PubMed DOI
  133. [YEAR:12-1-2006]Meade,J.L., de Wynter,E.A., Brett,P., Sharif,S.M., Woods,C.G., Markham,A.F. and Cook,G.P.
    A family with Papillon-Lefevre syndrome reveals a requirement for cathepsin C in granzyme B activation and NK cell cytolytic activity
    Blood107, 3665-3668. PubMed  Europe PubMed DOI  M
  134. [YEAR:27-6-2006]Tschopp,C.M., Spiegl,N., Didichenko,S., Lutmann,W., Julius,P., Virchow,J.C., Hack,C.E. and Dahinden,C.A.
    Granzyme B, a novel mediator of allergic inflammation: Its induction and release in blood basophils and human asthma
    Blood108, 2290-2299. PubMed  Europe PubMed DOI  T
    135. 2005
  135. [YEAR:29-11-2005]Adrain,C., Murphy,B.M. and Martin,S.J.
    Molecular ordering of the caspase activation cascade initiated by the cytotoxic T lymphocyte/natural killer (CTL/NK) protease granzyme B
    J Biol Chem280, 4663-4673. PubMed  Europe PubMed DOI
  136. Bird,C.H., Sun,J., Ung,K., Karambalis,D., Whisstock,J.C., Trapani,J.A. and Bird,P.I.
    Cationic sites on granzyme B contribute to cytotoxicity by promoting its uptake into target cells
    Mol Cell Biol25, 7854-7867. PubMed  Europe PubMed DOI
  137. Bredemeyer,A.J., Townsend,R.R. and Ley,T.J.
    Use of protease proteomics to discover granzyme B substrates
    Immunol Res32, 143-153. PubMed  Europe PubMed DOI
  138. [YEAR:19-4-2005]Buzza,M.S., Zamurs,L., Sun,J., Bird,C.H., Smith,A.I., Trapani,J.A., Froelich,C.J., Nice,E.C. and Bird,P.I.
    Extracellular matrix remodeling by human granzyme B via cleavage of vitronectin, fibronectin, and laminin
    J Biol Chem280, 23549-23558. PubMed  Europe PubMed DOI
  139. [YEAR:1-10-2005]Curtsinger,J.M., Lins,D.C., Johnson,C.M. and Mescher,M.F.
    Signal 3 tolerant CD8 T cells degranulate in response to antigen but lack granzyme B to mediate cytolysis
    J Immunol175, 4392-4399. PubMed  Europe PubMed
  140. Fynbo,C.H., Lorentsen,R.H., Etzerodt,M., Thogersen,H.C. and Holtet,T.L.
    Characterization of a recombinant granzyme B derivative as a "restriction" protease
    Protein Expr Purif39, 209-218. PubMed  Europe PubMed DOI
  141. [YEAR:7-10-2005]Goldbach-Mansky,R., Suson,S., Wesley,R., Hack,C.E., El-Gabalawy,H.S. and Tak,P.P.
    Raised granzyme B levels are associated with erosions in patients with early rheumatoid factor positive rheumatoid arthritis
    Ann Rheum Dis64, 715-721. PubMed  Europe PubMed DOI
  142. Lorentsen,R.H., Fynbo,C.H., Thogersen,H.C., Etzerodt,M. and Holtet,T.L.
    Expression, refolding, and purification of recombinant human granzyme B
    Protein Expr Purif39, 18-26. PubMed  Europe PubMed DOI  E
  143. Mahrus,S. and Craik,C.S.
    Selective chemical functional probes of granzymes A and B reveal granzyme B is a major effector of natural killer cell-mediated lysis of target cells
    Chem Biol12, 567-577. PubMed  Europe PubMed DOI
    144. 2004
  144. Andrade,F., Casciola-Rosen,L.A. and Rosen,A.
    Granzyme B-induced cell death
    Acta Haematol111, 28-41. PubMed  Europe PubMed DOI
  145. [YEAR:10-8-2004]Bredemeyer,A.J., Lewis,R.M., Malone,J.P., Davis,A.E., Gross,J., Townsend,R.R. and Ley,T.J.
    A proteomic approach for the discovery of protease substrates
    Proc Natl Acad Sci U S A101, 11785-11790. PubMed  Europe PubMed DOI
  146. [YEAR:7-10-2004]Choy,J.C., Hung,V.H., Hunter,A.L., Cheung,P.K., Motyka,B., Goping,I.S., Sawchuk,T., Bleackley,R.C., Podor,T.J., McManus,B.M. and Granville,D.J.
    Granzyme B induces smooth muscle cell apoptosis in the absence of perforin: involvement of extracellular matrix degradation
    Arterioscler Thromb Vasc Biol24, 2245-2250. PubMed  Europe PubMed DOI
  147. Froelich,C.J.
    Granzyme B
    [ISSN:0-12-079610-4]2, 1549-1552.  V
  148. Han,J., Goldstein,L.A., Gastman,B.R., Froelich,C.J., Yin,X.M. and Rabinowich,H.
    Degradation of Mcl-1 by granzyme B: implications for Bim-mediated mitochondrial apoptotic events
    J Biol Chem279, 22020-22029. PubMed  Europe PubMed DOI
  149. Rong,J., Xu,X., Ewen,C., Bleackley,R.C. and Kane,K.P.
    Isolation and characterization of novel single-chain Fv specific for human granzyme B
    Hybrid Hybridomics23, 219-231. PubMed  Europe PubMed DOI
  150. [YEAR:3-5-2004]Ruggles,S.W., Fletterick,R.J. and Craik,C.S.
    Characterization of structural determinants of granzyme B reveals potent mediators of extended substrate specificity
    J Biol Chem279, 30751-30759. PubMed  Europe PubMed DOI
  151. [YEAR:29-1-2004]Sun,J., Bird,C.H., Thia,K.Y., Matthews,A.Y., Trapani,J.A. and Bird,P.I.
    Granzyme B encoded by the commonly occurring human RAH allele retains pro-apoptotic activity
    J Biol Chem279, 16907-16911. PubMed  Europe PubMed DOI  M
  152. Wowk,M.E. and Trapani,J.A.
    Cytotoxic activity of the lymphocyte toxin granzyme B
    Microbes Infect6, 752-758. PubMed  Europe PubMed DOI
  153. Zhao,J., Wang,Z., Yu,C.J., Cao,Y.X., Zhang,L., Wang,C.J. and Yang,A.G.
    [Growth inhibitory effects of recombinant granzyme B containing different N-terminal translocating peptides]
    Sheng Wu Gong Cheng Xue Bao20, 501-506. PubMed  Europe PubMed
    154. 2003
  154. Andrade,F., Casciola-Rosen,L.A. and Rosen,A.
    A novel domain in adenovirus L4-100K is required for stable binding and efficient inhibition of human granzyme B: possible interaction with a species-specific exosite
    Mol Cell Biol23, 6315-6326. PubMed  Europe PubMed DOI
  155. Horiuchi,K., Saito,S., Sasaki,R., Tomatsu,T. and Toyama,Y.
    Expression of granzyme B in human articular chondrocytes
    J Rheumatol30, 1799-1810. PubMed  Europe PubMed
  156. [YEAR:5-9-2003]Sattar,R., Ali,S.A. and Abbasi,A.
    Bioinformatics of granzymes: sequence comparison and structural studies on granzyme family by homology modeling
    Biochem Biophys Res Commun308, 726-735. PubMed  Europe PubMed DOI
  157. [YEAR:15-7-2003]Smyth,M.J., Street,S.E. and Trapani,J.A.
    Cutting edge: granzymes A and B are not essential for perforin-mediated tumor rejection
    J Immunol171, 515-518. PubMed  Europe PubMed
  158. Trapani,J.A. and Sutton,V.R.
    Granzyme B: pro-apoptotic, antiviral and antitumor functions
    Curr Opin Immunol15, 533-543. PubMed  Europe PubMed DOI
    159. 2002
  159. Schachna,L., Wigley,F.M., Morris,S., Gelber,A.C., Rosen,A. and Casciola-Rosen,L.
    Recognition of Granzyme B-generated autoantigen fragments in scleroderma patients with ischemic digital loss
    Arthritis Rheum46, 1873-1884. PubMed  Europe PubMed DOI
  160. [YEAR:19-8-2002]Willoughby,C.A., Bull,H.G., Garcia-Calvo,M., Jiang,J., Chapman,K.T. and Thornberry,N.A.
    Discovery of potent, selective human granzyme B inhibitors that inhibit CTL mediated apoptosis
    Bioorg Med Chem Lett12, 2197-2200. PubMed  Europe PubMed DOI  I
    161. 2001
  161. Andrade,F., Bull,H.G., Thornberry,N.A., Ketner,G.W., Casciola-Rosen,L.A. and Rosen,A.
    Adenovirus L4-100K assembly protein is a granzyme B substrate that potently inhibits granzyme B-mediated cell death
    Immunity14, 751-761. PubMed  Europe PubMed DOI
  162. [YEAR:25-5-2001]Buzza,M.S., Hirst,C.E., Bird,C.H., Hosking,P., Mckendrick,J. and Bird,P.I.
    The granzyme B inhibitor, PI-9, is present in endothelial and mesothelial cells, suggesting that it protects bystander cells during immune responses
    Cell Immunol210, 21-29. PubMed  Europe PubMed DOI
  163. [YEAR:14-6-2001]McElhaney,J.E., Gravenstein,S., Upshaw,C.M., Hooton,J.W., Krause,P., Drinka,P. and Bleackley,R.C.
    Granzyme B: a marker of risk for influenza in institutionalized older adults
    Vaccine19, 3744-3751. PubMed  Europe PubMed DOI
  164. Ronday,H.K., van,d.L., Tak,P.P., de,R., Bank,R.A., TeKoppele,J.M., Froelich,C.J., Hack,C.E., Hogendoorn,P.C., Breedveld,F.C. and Verheijen,J.H.
    Human granzyme B mediates cartilage proteoglycan degradation and is expressed at the invasive front of the synovium in rheumatoid arthritis
    Rheumatology (Oxford)40, 55-61. PubMed  Europe PubMed
  165. Rotonda,J., Garcia-Calvo,M., Bull,H.G., Geissler,W.M., McKeever,B.M., Willoughby,C.A., Thornberry,N.A. and Becker,J.W.
    The three-dimensional structure of human granzyme B compared to caspase-3, key mediators of cell death with cleavage specificity for aspartic acid in P1
    Chem Biol8, 357-368. PubMed  Europe PubMed DOI  S
  166. [YEAR:15-6-2001]Sharif-Askari,E., Alam,A., Rheaume,E., Beresford,P.J., Scotto,C., Sharma,K., Lee,D., DeWolf,W.E., Nuttall,M.E., Lieberman,J. and Sekaly,R.P.
    Direct cleavage of the human DNA fragmentation factor-45 by granzyme B induces caspase-activated DNase release and DNA fragmentation
    EMBO J20, 3101-3113. PubMed  Europe PubMed DOI
  167. [YEAR:4-5-2001]Sun,J., Whisstock,J.C., Harriott,P., Walker,B., Novak,A., Thompson,P.E., Smith,A.I. and Bird,P.I.
    Importance of the P4' residue in human granzyme B inhibitors and substrates revealed by scanning mutagenesis of the proteinase inhibitor 9 reactive center loop
    J Biol Chem276, 15177-15184. PubMed  Europe PubMed DOI
  168. [YEAR:8-5-2001]Zhang,D., Beresford,P.J., Greenberg,A.H. and Lieberman,J.
    Granzymes A and B directly cleave lamins and disrupt the nuclear lamina during granule-mediated cytolysis
    Proc Natl Acad Sci U S A98, 5746-5751. PubMed  Europe PubMed DOI
    169. 2000
  169. Estebanez-Perpina,E., Fuentes-Prior,P., Belorgey,D., Braun,M., Kiefersauer,R., Maskos,K., Huber,R., Rubin,H. and Bode,W.
    Crystal structure of the caspase activator human granzyme B, a proteinase highly specific for an Asp-P1 residue
    Biol Chem381, 1203-1214. PubMed  Europe PubMed DOI  S
  170. Shi,L., Yang,X., Froelich,C.J. and Greenberg,A.H.
    Purification and use of granzyme B
    Methods Enzymol322, 125-143. PubMed  Europe PubMed  V
    171. 1999
  171. Casciola-Rosen,L., Andrade,F., Ulanet,D., Wong,W.B. and Rosen,A.
    Cleavage by granzyme B is strongly predictive of autoantigen status: implications for initiation of autoimmunity
    J Exp Med190, 815-826. PubMed  Europe PubMed DOI  P
  172. [YEAR:2-8-1999]Sun,J., Bird,C.H., Buzza,M.S., McKee,K.E., Whisstock,J.C. and Bird,P.I.
    Expression and purification of recombinant human granzyme B from Pichia pastoris
    Biochem Biophys Res Commun261, 251-255. PubMed  Europe PubMed DOI  E
    173. 1998
  173. [YEAR:1-4-1998]Spaeny-Dekking,E.H., Hanna,W.L., Wolbink,A.M., Wever,P.C., Kummer,A.J., Swaak,A.J., Middeldorp,J.M., Huisman,H.G., Froelich,C.J. and Hack,C.E.
    Extracellular granzymes A and B in humans: detection of native species during CTL responses in vitro and in vivo
    J Immunol160, 3610-3616. PubMed  Europe PubMed
    174. 1997
  174. [YEAR:18-7-1997]Thornberry,N.A., Rano,T.A., Peterson,E.P., Rasper,D.M., Timkey,T., Garcia-Calvo,M., Houtzager,V.M., Nordstrom,P.A., Roy,S., Vaillancourt,J.P., Chapman,K.T. and Nicholson,D.W.
    A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis
    J Biol Chem272, 17907-17911. PubMed  Europe PubMed DOI  P
    175. 1996
  175. Chinnaiyan,A.M., Hanna,W.L., Orth,K., Duan,H., Poirier,G.G., Froelich,C.J. and Dixit,V.M.
    Cytotoxic T-cell-derived granzyme B activates the apoptotic protease ICE-LAP3
    Curr Biol6, 897-899. PubMed  Europe PubMed DOI
  176. [YEAR:15-11-1996]Froelich,C.J., Orth,K., Turbov,J., Seth,P., Gottlieb,R., Babior,B., Shah,G.M., Bleackley,R.C., Dixit,V.M. and Hanna,W.
    New paradigm for lymphocyte granule-mediated cytotoxicity. Target cells bind and internalize granzyme B, but an endosomolytic agent is necessary for cytosolic delivery and subsequent apoptosis
    J Biol Chem271, 29073-29079. PubMed  Europe PubMed DOI
  177. Froelich,C.J., Hanna,W.L., Poirier,G.G., Duriez,P.J., D'Amours,D., Salvesen,G.S., Alnemri,E.S., Earnshaw,W.C. and Shah,G.M.
    Granzyme B/perforin-mediated apoptosis of jurkat cells results in cleavage of poly(ADP-ribose) polymerase to the 89-kDa apoptotic fragment and less abundant 64-kDa fragment
    Biochem Biophys Res Commun227, 658-665. PubMed  Europe PubMed DOI
    178. 1994
  178. Su,B., Bochan,M.R., Hanna,W.L., Froelich,C.J. and Brahmi,Z.
    Human granzyme B is essential for DNA fragmentation of susceptible target cells
    Eur J Immunol24, 2073-2080. PubMed  Europe PubMed DOI
    179. 1993
  179. [YEAR:15-12-1993]Froelich,C.J., Zhang,X., Turbov,J., Hudig,D., Winkler,U. and Hanna,W.L.
    Human granzyme B degrades aggrecan proteoglycan in matrix synthesized by chondrocytes
    J Immunol151, 7161-7171. PubMed  Europe PubMed
  180. Hanna,W.L., Zhang,X., Turbov,J., Winkler,U., Hudig,D. and Froelich,C.J.
    Rapid purification of cationic granule proteases: application to human granzymes
    Protein Expr Purif4, 398-404. PubMed  Europe PubMed DOI
  181. [YEAR:6-7-1993]Kummer,J.A., Kamp,A.M., van Katwijk,M., Brakenhoff,J.P., Radosevic,K., van Leeuwen,A.M., Borst,J., Verweij,C.L. and Hack,C.E.
    Production and characterization of monoclonal antibodies raised against recombinant human granzymes A and B and showing cross reactions with the natural proteins
    J Immunol Methods163, 77-83. PubMed  Europe PubMed DOI
    182. 1990
  182. Dahl,C.A., Bach,F.H., Chan,W., Huebner,K., Russo,G., Croce,C.M., Herfurth,T. and Cairns,J.S.
    Isolation of a cDNA clone encoding a novel form of granzyme B from human NK cells and mapping to chromosome 14
    Hum Genet84, 465-470. PubMed  Europe PubMed
  183. Haddad,P., Clement,M.V., Bernard,O., Larsen,C.J., Degos,L., Sasportes,M. and Mathieu-Mahul,D.
    Structural organization of the hCTLA-1 gene encoding human granzyme B
    Gene87, 265-271. PubMed  Europe PubMed DOI
    184. 1989
  184. Klein,J.L., Shows,T.B., Dupont,B. and Trapani,J.A.
    Genomic organization and chromosomal assignment for a serine protease gene (CSPB) expressed by human cytotoxic lymphocytes
    Genomics5, 110-117. PubMed  Europe PubMed

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