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Literature for peptidase S01.010: granzyme B (Homo sapiens-type)

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, I Inhibitor, L Localization, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

    2026
  1. Jung,S., Ju,M., Park,H., Kang,S., Kim,J., Seo,Y., Kang,J., Jang,J.G., Choi,J.H., Kim,D.H., Park,C., Lee,M.H., Lee,W. and Lee,T.<br>Novel Respiratory Disease Diagnosis Tool: Development of an Au-ReS(2)-Functionalized Extended-gate Field-Effect Transistor-Type Aptasensor for Simultaneous Detection of Granzyme B and Perforin<br>Small Sci (2026) 6, e202500485-e202500485. PubMed  Europe PubMed DOI  PMC  EPMC
    2. 2025
  2. Ding,L., Zhang,X., Wang,P., Ke,J., Zhou,Y., Wu,M., Wei,Z., Cao,Y., Li,H., Chen,G., Zheng,G., Zeng,Y., Hong,M. and Liu,X.<br>Granzyme B activated near-infrared-II ratiometric fluorescent nanoprobe for early detection of tumor response to immunotherapy<br>Nat Commun (2025) 16, 8054-8054. PubMed  Europe PubMed DOI  PMC  EPMC
  3. Hu,Q.L. and Liang,S.H.<br>Cyclic Peptides Targeting Granzyme B: Potential Applications as PET Imaging Agents<br>ACS Med Chem Lett (2025) 16, 180-181. PubMed  Europe PubMed DOI  PMC  EPMC
  4. Kazim,M., Ganguly,A., Malespini,S.M., Thang,L., Patel,N.L., Kim,C., Thakur,K., Kalen,J.D., Calcagno,C., Difilippantonio,S. and Yoo,E.<br>Granzyme B-Targeting Quenched Activity-Based Probes for Assessing Tumor Response to Immunotherapy<br>J Am Chem Soc (2025) 147, 37926-37939. PubMed  Europe PubMed DOI  PMC  EPMC
  5. Kim,J.T., Park,E.S., Hwang,Y.S., Yoon,H.R., Yoon,S.R., Cho,H.J. and Lee,H.G.<br>Attenuation of natural killer cell cytotoxicity by interaction between NKp30 of NK cells and dipeptidase 1 of colon cancer cells<br>Sci Rep (2025) 15, 34777-34777. PubMed  Europe PubMed DOI  PMC  EPMC  K
  6. Lane,M., Aubert,A., Prudova,A., Liu,F., Russo,V., Jung,K., Khosravi-Hafshejani,T., Zhao,H., Crawford,R.I., Phillips,E. and Granville,D.J.<br>Extracellular Granzyme B mediates degradation of Collagen XVII in Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis<br>J Invest Dermatol (2025) PubMed  Europe PubMed DOI
  7. Liu,L., Wang,J. and Liu,C.<br>Granzyme B as a potential biological target in toxic encephalopathy: A big data-based exploratory analysis<br>Medicine (Baltimore) (2025) 104, e43879-e43879. PubMed  Europe PubMed DOI  PMC  EPMC
  8. Maleka,M.N., Mbita,Z. and Morafo,V.<br>Regulation of Granzymes A and B by High-Risk HPV: Impact on Immune Evasion and Carcinogenesis<br>Viruses (2025) 17 PubMed  Europe PubMed DOI  PMC  EPMC  V
  9. Wei,R., Lei,L., Wu,L.L., Zhang,L. and Hu,H.Y.<br>Self-Immobilizing Fluorogenic Probe for In Situ Labeling of Granzyme B Activity in Host Immune Response to Bacterial Infections<br>Chembiochem (2025) , e202400990-e202400990. PubMed  Europe PubMed DOI
  10. Wu,L.Z., Huang,Y.Y., Hu,H.J., Hong,W.B., Yan,H., Ai,Y.L., Mi,X.Y., Feng,D.Y., Guo,J.Y., Ding,Y., Liu,Z.J., Zhou,B., Xiao,L., Lin,T., Li,F.N., Chen,X.Q., Chen,H.Z. and Wu,Q.<br>Disruption of heme homeostasis by nuclear receptor Nur77 induces pyroptosis through granzyme B-dependent GSDMC cleavage<br>Signal Transduct Target Ther (2025) 10, 413-413. PubMed  Europe PubMed DOI  PMC  EPMC
  11. Xu,H., Zhang,J., Wei,Z., Wang,X., Yang,M.F. and Yang,X.<br>Development of a novel (18)F-labeled radiotracer targeting granzyme B for imaging early tumor responses to immunotherapy<br>J Immunother Cancer (2025) 13 PubMed  Europe PubMed DOI  PMC  EPMC
  12. Yan,J., Feng,R., Qin,Q., Shen,G., Tian,M., Ling,S., Zhou,S., Li,F., Xia,X., Cao,Y., Zeng,L., Shao,C., Sun,X. and Zheng,W.<br>NK cell-derived GZMB (granzyme B) suppresses glioblastoma radioresistance by blocking SDC1-mediated autophagosome maturation<br>Autophagy (2025) PubMed  Europe PubMed DOI
  13. Yoo,H.S., Chakravarthy,H., Xi,J., Cui,J., Ai,Z., Hosseini,A., Song,J., Tan,N., Ma,N., Zhou,C., Li,B., Bell,R., Haegert,A., Le Bihan,S., Ju,M.J., Granville,D.J. and Matsubara,J.A.<br>Granzyme B contributes to subretinal fibrosis in neovascular age-related macular degeneration by modulating inflammation and epithelial-mesenchymal transition<br>J Neuroinflammation (2025) PubMed  Europe PubMed DOI
  14. Zhang,Y., Huang,H., Xie,L., Li,C. and Zhou,X.<br>The pro-tumorigenic roles of granzyme B: mechanisms and therapeutic implications<br>Front Immunol (2025) 16, 1733793-1733793. PubMed  Europe PubMed DOI  PMC  EPMC
    15. 2024
  15. Anderson,T.S., McCormick,A.L., Smith,S.L. and Lowe,D.B.<br>Modeling antibody drug conjugate potential using a granzyme B antibody fusion protein<br>BMC Biol (2024) 22, 66-66. PubMed  Europe PubMed DOI  PMC  EPMC
  16. Aubert,A., Liu,A., Kao,M., Goeres,J., Richardson,K.C., Nierves,L., Jung,K., Nabai,L., Zhao,H., Orend,G., Krawetz,R., Lange,P.F., Younger,A., Chan,J. and Granville,D.J.<br>Granzyme B cleaves Tenascin-C to release its C-terminal domain in rheumatoid arthritis<br>JCI Insight (2024) 9, e181935-e181935. PubMed  Europe PubMed DOI
  17. Aubert,A., Goeres,J., Liu,A., Kao,M., Richardson,K.C., Jung,K., Hinz,B., Crawford,R.I. and Granville,D.J.<br>Potential implications of granzyme B in keloids and hypertrophic scars through extracellular matrix remodeling and latent TGF-beta activation<br>Front Immunol (2024) 15, 1484462-1484462. PubMed  Europe PubMed DOI  PMC  EPMC
  18. Ben-Eltriki,M., Ahmadi,A.R., Nakao,Y., Golla,K., Lakschevitz,F., Hakkinen,L., Granville,D.J. and Kim,H.<br>Granzyme B promotes matrix metalloproteinase-1 (MMP-1) release from gingival fibroblasts in a PAR1- and Erk1/2-dependent manner: A novel role in periodontal inflammation<br>J Periodontal Res (2024) 59, 94-103. PubMed  Europe PubMed DOI
  19. Gill,K., Yoo,H.S., Chakravarthy,H., Granville,D.J. and Matsubara,J.A.<br>Exploring the role of granzyme B in subretinal fibrosis of age-related macular degeneration<br>Front Immunol (2024) 15, 1421175-1421175. PubMed  Europe PubMed DOI  PMC  EPMC  V
  20. Kellerer,M., Javed,S., Casar,C., Will,N., Berkhout,L.K., Schwinge,D., Krebs,C.F., Schramm,C., Neumann,K. and Tiegs,G.<br>Antagonistic effects of the cytotoxic molecules granzyme B and TRAIL in the immunopathogenesis of sclerosing cholangitis<br>Hepatology (2024) 80, 844-858. PubMed  Europe PubMed DOI
  21. Li,Z., Ma,R., Tang,H., Guo,J., Shah,Z., Zhang,J., Liu,N., Cao,S., Marcucci,G., Artis,D., Caligiuri,M.A. and Yu,J.<br>Therapeutic application of human type 2 innate lymphoid cells via induction of granzyme B-mediated tumor cell death<br>Cell (2024) 187, 624-641. PubMed  Europe PubMed DOI
  22. Mandal,M., Pires,D., Calado,M., Azevedo-Pereira,J.M. and Anes,E.<br>Cystatin F Depletion in Mycobacterium tuberculosis-Infected Macrophages Improves Cathepsin C/Granzyme B-Driven Cytotoxic Effects on HIV-Infected Cells during Coinfection<br>Int J Mol Sci (2024) 25 PubMed  Europe PubMed DOI  PMC  EPMC
  23. Obasanmi,G., Uppal,M., Cui,J.Z., Xi,J., Ju,M.J., Song,J., To,E., Li,S., Khan,W., Cheng,D., Zhu,J., Irani,L., Samad,I., Zhu,J., Yoo,H.S., Aubert,A., Stoddard,J., Neuringer,M., Granville,D.J. and Matsubara,J.A.<br>Granzyme B degrades extracellular matrix and promotes inflammation and choroidal neovascularization<br>Angiogenesis (2024) 27, 351-373. PubMed  Europe PubMed DOI
  24. Richardson,K.C., Jung,K., Matsubara,J.A., Choy,J.C. and Granville,D.J.<br>Granzyme B in aging and age-related pathologies<br>Trends Mol Med (2024) 30, 1165-1179. PubMed  Europe PubMed DOI  V
  25. Shi,Z., Yan,J., Zhao,M., Li,S., She,T. and Qian,X.<br>Co-encapsulation of granzyme B and perforin in nanocapsules for tumour therapy: biomimicking immune cells<br>J Control Release (2024) 369, 658-667. PubMed  Europe PubMed DOI
  26. Thompson,R. and Cao,X.<br>Reassessing granzyme B: unveiling perforin-independent versatility in immune responses and therapeutic potentials<br>Front Immunol (2024) 15, 1392535-1392535. PubMed  Europe PubMed DOI  PMC  EPMC  V
  27. Thulin,H., Safholm,J., Lundahl,J., Jovic,V., Adner,M. and Nilsson,C.<br>Granzyme B is elevated in esophageal biopsies from children with eosinophilic esophagitis<br>J Pediatr Gastroenterol Nutr (2024) 78, 313-319. PubMed  Europe PubMed DOI
    28. 2023
  28. Bruning,N., Bonnemann,V. and Watzl,C.<br>Analyzing the activity of the proteases granzyme B and caspase-8 inside living cells using fluorescence localization reporters<br>Methods Cell Biol (2023) 178, 13-24. PubMed  Europe PubMed DOI
  29. Dawodu,D., Sand,S., Nikolouli,E., Werfel,T. and Mommert,S.<br>The mRNA expression and secretion of granzyme B are up-regulated via the histamine H2 receptor in human CD4(+) T cells<br>Inflamm Res (2023) 72, 1525-1538. PubMed  Europe PubMed DOI  PMC  EPMC
  30. Gao,T., Yi,L., Wang,Y., Wang,W., Zhao,Q., Song,Y., Ding,M., Deng,C., Chen,Y., Xie,Y., Wu,W., Jin,Q., Zhang,L. and Xie,M.<br>Granzyme B-responsive fluorescent probe for non-invasive early diagnosis of transplant rejection<br>Biosens Bioelectron (2023) 232, 115303-115303. PubMed  Europe PubMed DOI
  31. Jin,Y., Gao,P., Liang,L., Wang,Y., Li,J., Wang,J., Hou,J., Yang,C. and Wang,X.<br>Noninvasive quantification of granzyme B in cardiac allograft rejection using targeted ultrasound imaging<br>Front Immunol (2023) 14, 1164183-1164183. PubMed  Europe PubMed DOI  PMC  EPMC
  32. Kazuta,N., Watanabe,H. and Ono,M.<br>Synthesis and evaluation of (111) In-labeled tetrapeptide-based compounds as single-photon emission computed tomography imaging probes targeting granzyme B<br>J Labelled Comp Radiopharm (2023) 66, 298-307. PubMed  Europe PubMed DOI
  33. Kumagai,J., Kiuchi,M., Kokubo,K., Yagyu,H., Nemoto,M., Tsuji,K., Nagahata,K., Sasaki,A., Hishiya,T., Onoue,M., Shinmi,R., Sonobe,Y., Iinuma,T., Yonekura,S., Shinga,J., Hanazawa,T., Koseki,H., Nakayama,T., Yokote,K. and Hirahara,K.<br>The USP7-STAT3-granzyme-Par-1 axis regulates allergic inflammation by promoting differentiation of IL-5-producing Th2 cells<br>Proc Natl Acad Sci U S A (2023) 120, e2302903120-e2302903120. PubMed  Europe PubMed DOI  PMC  EPMC
  34. Li,X., Chen,G., Wu,K., Zheng,H., Tian,Z., Xu,Z., Zhao,W., Weng,J. and Min,Y.<br>Imaging and monitoring of granzyme B in the immune response<br>Wiley Interdiscip Rev Nanomed Nanobiotechnol (2023) , e1928-e1928. PubMed  Europe PubMed DOI  V
  35. Lim,Y.S., Lee,A.G., Jiang,X., Scott,J.M., Cofie,A., Kumar,S., Kennedy,D., Granville,D.J. and Shin,H.<br>NK cell-derived extracellular granzyme B drives epithelial ulceration during HSV-2 genital infection<br>Cell Rep (2023) 42, 112410-112410. PubMed  Europe PubMed DOI
  36. Xu,C., He,S., Wei,X., Huang,J., Xu,M. and Pu,K.<br>Activatable Sonoafterglow Nanoprobes for T-Cell Imaging<br>Adv Mater (2023) 35, e2211651-e2211651. PubMed  Europe PubMed DOI
    37. 2022
  37. Hadi,M., Akbari,A., Dehbidi,G.R., Arabsolghar,R. and Bahmani,T.<br>Expression and Purification of Human Granzyme B Fusion Protein to Induce Targeted Apoptosis in PSMA Positive Prostate Cancer Cells<br>Protein Pept Lett (2022) 29, 631-640. PubMed  Europe PubMed DOI
  38. Jung,K., Pawluk,M.A., Lane,M., Nabai,L. and Granville,D.J.<br>Granzyme B in epithelial barrier dysfunction and related skin diseases<br>Am J Physiol Cell Physiol (2022) 323, C170-C170. PubMed  Europe PubMed DOI  V
  39. Scott,J.I., Mendive-Tapia,L., Gordon,D., Barth,N.D., Thompson,E.J., Cheng,Z., Taggart,D., Kitamura,T., Bravo-Blas,A., Roberts,E.W., Juarez-Jimenez,J., Michel,J., Piet,B., de Vries,I.J., Verdoes,M., Dawson,J., Carragher,N.O., Connor,R.A.O., Akram,A.R., Frame,M., Serrels,A. and Vendrell,M.<br>A fluorogenic probe for granzyme B enables in-biopsy evaluation and screening of response to anticancer immunotherapies<br>Nat Commun (2022) 13, 2366-2366. PubMed  Europe PubMed DOI  PMC  EPMC
  40. Tibbs,E. and Cao,X.<br>Emerging Canonical and Non-Canonical Roles of Granzyme B in Health and Disease<br>Cancers (Basel) (2022) 14 PubMed  Europe PubMed DOI  PMC  EPMC  V
  41. Tripathi,N., Danger,R., Chesneau,M., Brouard,S. and Laurent,A.D.<br>Structural insights into the catalytic mechanism of granzyme B upon substrate and inhibitor binding<br>J Mol Graph Model (2022) 114, 108167-108167. PubMed  Europe PubMed DOI
  42. Zhang,Q., Wang,Q. and Zhang,L.X.<br>Granzyme B: A novel therapeutic target for treatment of atopic dermatitis<br>Indian J Dermatol Venereol Leprol (2022) , 1-4. PubMed  Europe PubMed DOI  V
    43. 2021
  43. Burgener,S.S., Brugger,M., Leborgne,N.G.F., Sollberger,S., Basilico,P., Kaufmann,T., Bird,P.I. and Benarafa,C.<br>Granule Leakage Induces Cell-Intrinsic, Granzyme B-Mediated Apoptosis in Mast Cells<br>Front Cell Dev Biol (2021) 9, 630166-630166. PubMed  Europe PubMed DOI  PMC  EPMC
  44. Hiroyasu,S., Zeglinski,M.R., Zhao,H., Pawluk,M.A., Turner,C.T., Kasprick,A., Tateishi,C., Nishie,W., Burleigh,A., Lennox,P.A., Van Laeken,N., Carr,N.J., Petersen,F., Crawford,R.I., Shimizu,H., Tsuruta,D., Ludwig,R.J. and Granville,D.J.<br>Granzyme B inhibition reduces disease severity in autoimmune blistering diseases<br>Nat Commun (2021) 12, 302-302. PubMed  Europe PubMed DOI  PMC  EPMC
  45. Shi,H., Gong,Y., Liang,Q., Li,J., Xiang,Y. and Li,G.<br>Target-Initiated Great Change in Electrochemical Steric Hindrance for an Assay of Granzyme B Activity<br>Anal Chem (2021) 93, 13382-13388. PubMed  Europe PubMed DOI
    46. 2020
  46. Alvarez de Cienfuegos,A., Cheung,L.H., Mohamedali,K.A., Whitsett,T.G., Winkles,J.A., Hittlerman,W.N. and Rosenblum,M.G.<br>Therapeutic efficacy and safety of a human fusion construct targeting the TWEAK receptor Fn14 and containing a modified granzyme B<br>J Immunother Cancer (2020) 8 PubMed  Europe PubMed DOI  PMC  EPMC
  47. Bou-Dargham,M.J. and Sang,Q.A.<br>Secretome analysis reveals upregulated granzyme B in human androgen-repressed prostate cancer cells with mesenchymal and invasive phenotype<br>PLoS ONE (2020) 15, e0237222-e0237222. PubMed  Europe PubMed DOI  PMC  EPMC  K
  48. Briones,J.C., Espulgar,W.V., Koyama,S., Yoshikawa,H., Park,J., Naito,Y., Kumanogoh,A., Tamiya,E., Takamatsu,H. and Saito,M.<br>A microfluidic platform for single cell fluorometric granzyme B profiling<br>Theranostics (2020) 10, 123-132. PubMed  Europe PubMed DOI  PMC  EPMC  L
  49. Capaccione,K.M., Doubrovin,M., Bhatt,N., Mintz,A. and Molotkov,A.<br>Granzyme B PET Imaging of the Innate Immune Response<br>Molecules (2020) 25 PubMed  Europe PubMed DOI
  50. Fu,Z., Akula,S., Thorpe,M. and Hellman,L.<br>Extended cleavage specificities of two mast cell chymase-related proteases and one granzyme B-like protease from the platypus, a monotreme<br>Int J Mol Sci (2020) 21 PubMed  Europe PubMed DOI
  51. Holt,B.A. and Kwong,G.A.<br>Protease circuits for processing biological information<br>Nat Commun (2020) 11, 5021-5021. PubMed  Europe PubMed DOI  PMC  EPMC
  52. Islimye Taskin,M., Guney,G., Adali,E., Hismiogullari,A.A., Dodurga,Y. and Elmas,L.<br>Granzyme B levels and granzyme B polymorphisms in peripheral blood of patients with endometriosis: a preliminary study<br>J Obstet Gynaecol (2020) , 1-6. PubMed  Europe PubMed DOI  V
  53. Jensen,C., Sinkeviciute,D., Madsen,D.H., Onnerfjord,P., Hansen,M., Schmidt,H., Karsdal,M.A., Svane,I.M. and Willumsen,N.<br>Granzyme B Degraded Type IV Collagen Products in Serum Identify Melanoma Patients Responding to Immune Checkpoint Blockade<br>Cancers (Basel) (2020) 12 PubMed  Europe PubMed DOI  PMC  EPMC
  54. Matsubara,J.A., Tian,Y., Cui,J.Z., Zeglinski,M.R., Hiroyasu,S., Turner,C.T. and Granville,D.J.<br>Retinal distribution and extracellular activity of granzyme B: a serine protease that degrades retinal pigment epithelial tight junctions and extracellular matrix proteins<br>Front Immunol (2020) 11, 574-574. PubMed  Europe PubMed DOI  PMC  EPMC
  55. Parra,M., Weitner,M., Yang,A., Akue,A., Liu,X., Schmidt,T., Allman,W.R., Akkoyunlu,M. and Derrick,S.C.<br>Memory CD73+IgM+ B cells protect against Plasmodium yoelii infection and express Granzyme B<br>PLoS ONE (2020) 15, e0238493-e0238493. PubMed  Europe PubMed DOI  PMC  EPMC
  56. Prunk,M., Perisic Nanut,M., Jakos,T., Sabotic,J., Svajger,U. and Kos,J.<br>Extracellular Cystatin F Is Internalised by Cytotoxic T Lymphocytes and Decreases Their Cytotoxicity<br>Cancers (Basel) (2020) 12 PubMed  Europe PubMed DOI  PMC  EPMC
    57. 2019
  57. Chaves-Pozo,E., Valero,Y., Lozano,M.T., Rodriguez-Cerezo,P., Miao,L., Campo,V., Esteban,M.A. and Cuesta,A.<br>Fish granzyme A shows a greater role than granzyme B in fish innate cell-mediated cytotoxicity<br>Front Immunol (2019) 10, 2579-2579. PubMed  Europe PubMed DOI  PMC  EPMC
  58. Gerada,C., Steain,M., Campbell,T.M., McSharry,B., Slobedman,B. and Abendroth,A.<br>Granzyme B cleaves multiple HSV-1 and VZV gene products and VZV ORF4 inhibits Natural Killer cell dependent cytotoxicity<br>J Virol (2019) 93, e01140-19-e01140-19. PubMed  Europe PubMed DOI
  59. Mac,Q.D., Mathews,D.V., Kahla,J.A., Stoffers,C.M., Delmas,O.M., Holt,B.A., Adams,A.B. and Kwong,G.A.<br>Non-invasive early detection of acute transplant rejection via nanosensors of granzyme B activity<br>Nat Biomed Eng (2019) 3, 281-291. PubMed  Europe PubMed DOI  PMC  EPMC  A
  60. Turner,C.T., Lim,D. and Granville,D.J.<br>Granzyme B in skin inflammation and disease<br>Matrix Biol (2019) 75-76, 126-140. PubMed  Europe PubMed DOI
  61. Turner,C.T., Hiroyasu,S. and Granville,D.J.<br>Granzyme B as a therapeutic target for wound healing<br>Expert Opin Ther Targets (2019) 23, 745-754. PubMed  Europe PubMed DOI
    62. 2018
  62. Du,W., Mohammadpour,H., O'Neill,R.E., Kumar,S., Chen,C., Qiu,M., Mei,L., Qiu,J., McCarthy,P.L., Lee,K.P. and Cao,X.<br>Serine protease inhibitor 6 protects alloreactive T cells from granzyme B-mediated mitochondrial damage without affecting graft-versus-tumor effect<br>Oncoimmunology (2018) 7, e1397247-e1397247. PubMed  Europe PubMed DOI  PMC  EPMC
  63. Liesche,C., Sauer,P., Prager,I., Urlaub,D., Claus,M., Eils,R., Beaudouin,J. and Watzl,C.<br>Single-fluorescent protein reporters allow parallel quantification of natural killer cell-mediated granzyme and caspase activities in single target cells<br>Front Immunol (2018) 9, 1840-1840. PubMed  Europe PubMed DOI  PMC  EPMC  L
  64. Russo,V., Klein,T., Lim,D.J., Solis,N., Machado,Y., Hiroyasu,S., Nabai,L., Shen,Y., Zeglinski,M.R., Zhao,H., Oram,C.P., Lennox,P.A., Van Laeken,N., Carr,N.J., Crawford,R.I., Franzke,C.W., Overall,C.M. and Granville,D.J.<br>Granzyme B is elevated in autoimmune blistering diseases and cleaves key anchoring proteins of the dermal-epidermal junction<br>Sci Rep (2018) 8, 9690-9690. PubMed  Europe PubMed DOI
  65. Saito,A., Okiyama,N., Kubota,N., Nakamura,Y., Fujisawa,Y., Watanabe,R., Ishitsuka,Y., Bleackley,R.C. and Fujimoto,M.<br>Blockade of granzyme B remarkably improves mucocutaneous diseases with keratinocyte death in interface dermatitis<br>J Invest Dermatol (2018) 138, 2079-2083. PubMed  Europe PubMed DOI
    66. 2017
  66. Darrah,E., Kim,A., Zhang,X., Boronina,T., Cole,R.N., Fava,A., Giles,J.T., Iii,C.O., Chalmers,M.J., Griffin,P.R., Sadegh-Nasseri,S. and Rosen,A.<br>Proteolysis by granzyme B enhances presentation of autoantigenic peptidylarginine deiminase 4 epitopes in rheumatoid arthritis<br>J Proteome Res (2017) 16, 355-365. PubMed  Europe PubMed DOI
  67. Dotiwala,F., Sen Santara,S., Binker-Cosen,A.A., Li,B., Chandrasekaran,S. and Lieberman,J.<br>Granzyme B disrupts central metabolism and protein synthesis in bacteria to promote an immune cell death program<br>Cell (2017) 171, 1125-1137. PubMed  Europe PubMed DOI
  68. Hofer,U.<br>Host response: granzyme B's roundhouse kick against bacteria<br>Nat Rev Microbiol (2017) 15, 707-707. PubMed  Europe PubMed DOI
  69. Larimer,B.M., Wehrenberg-Klee,E., Dubois,F., Mehta,A., Kalomeris,T., Flaherty,K., Boland,G. and Mahmood,U.<br>Granzyme B PET imaging as a predictive biomarker of immunotherapy response<br>Cancer Res (2017) 77, 2318-2327. PubMed  Europe PubMed DOI  L
  70. Lee,P.R., Johnson,T.P., Gnanapavan,S., Giovannoni,G., Wang,T., Steiner,J.P., Medynets,M., Vaal,M.J., Gartner,V. and Nath,A.<br>Protease-activated receptor-1 activation by granzyme B causes neurotoxicity that is augmented by interleukin-1beta<br>J Neuroinflammation (2017) 14, 131-131. PubMed  Europe PubMed DOI
    71. 2016
  71. Merkulova,Y., Shen,Y., Parkinson,L.G., Raithatha,S.A., Zhao,H., Westendorf,K., Sharma,M., Bleackley,R.C. and Granville,D.J.<br>Granzyme B inhibits keratinocyte migration by disrupting epidermal growth factor receptor (EGFR)-mediated signaling<br>Biol Chem (2016) 397, 883-895. PubMed  Europe PubMed DOI
  72. Niesen,J., Hehmann-Titt,G., Woitok,M., Fendel,R., Barth,S., Fischer,R. and Stein,C.<br>A novel fully-human cytolytic fusion protein based on granzyme B shows in vitro cytotoxicity and ex vivo binding to solid tumors overexpressing the epidermal growth factor receptor<br>Cancer Lett (2016) 374, 229-240. PubMed  Europe PubMed DOI  U
  73. Shen,Y., Cheng,F., Sharma,M., Merkulova,Y., Raithatha,S.A., Parkinson,L.G., Zhao,H., Westendorf,K., Bohunek,L., Bozin,T., Hsu,I., Ang,L.S., Williams,S.J., Bleackley,R.C., Eriksson,J.E., Seidman,M.A., McManus,B.M. and Granville,D.J.<br>Granzyme B deficiency protects against angiotensin II-induced cardiac fibrosis<br>Am J Pathol (2016) 186, 87-100. PubMed  Europe PubMed DOI  K
    74. 2015
  74. Azzi,J., Ohori,S., Ting,C., Uehara,M., Abdoli,R., Smith,B.D., Safa,K., Solhjou,Z., Lukyanchykov,P., Patel,J., McGrath,M. and Abdi,R.<br>Serine protease inhibitor-6 differentially affects the survival of effector and memory alloreactive CD8-T cells<br>Am J Transplant (2015) 15, 234-241. PubMed  Europe PubMed DOI
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