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Literature for peptidase M20.006: carnosine dipeptidase I

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: A Assay, M Mutation, K Knockout, P Specificity, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Regazzoni,L.<br>State of the Art in the Development of Human Serum Carnosinase Inhibitors<br>Molecules (2024) 29 PubMed  Europe PubMed DOI  PMC  EPMC  V
  2. Toviwek,B., Koonawootrittriron,S., Suwanasopee,T., Jattawa,D. and Pongprayoon,P.<br>Why Bestatin Prefers Human Carnosinase 2 (CN2) to Human Carnosinase 1 (CN1)<br>J Phys Chem B (2024) PubMed  Europe PubMed DOI  I
    3. 2021
  3. Rodriguez-Nino,A., Pastene,D.O., Post,A., Said,M.Y., Gomes-Neto,A.W., Kieneker,L.M., Heiner-Fokkema,M.R., Esatbeyoglu,T., Rimbach,G., Schnuelle,P., Yard,B.A. and Bakker,S.J.L.<br>Urinary Carnosinase-1 Excretion is Associated with Urinary Carnosine Depletion and Risk of Graft Failure in Kidney Transplant Recipients: Results of the TransplantLines Cohort Study<br>Antioxidants (Basel) (2021) 10 PubMed  Europe PubMed DOI  PMC  EPMC
  4. Zhou,Z., Liu,X.Q., Zhang,S.Q., Qi,X.M., Zhang,Q., Yard,B. and Wu,Y.G.<br>Correlation between serum carnosinase concentration and renal damage in diabetic nephropathy patients<br>Amino Acids (2021) 53, 687-700. PubMed  Europe PubMed DOI
    5. 2020
  5. Gilardoni,E., Gervasoni,S., Maspero,M., Dallanoce,C., Vistoli,G., Carini,M., Aldini,G. and Regazzoni,L.<br>Development of a direct LC-ESI-MS method for the measurement of human serum carnosinase activity<br>J Pharm Biomed Anal (2020) 189, 113440-113440. PubMed  Europe PubMed DOI
    6. 2019
  6. Qiu,J., Hauske,S.J., Zhang,S., Rodriguez-Nino,A., Albrecht,T., Pastene,D.O., Van den Born,J., van Goor,H., Ruf,S., Kohlmann,M., Teufel,M., Kramer,B.K., Hammes,H.P., Peters,V., Yard,B.A. and Kannt,A.<br>Identification and characterisation of carnostatine (SAN9812), a potent and selective carnosinase (CN1) inhibitor with in vivo activity<br>Amino Acids (2019) 51, 7-16. PubMed  Europe PubMed DOI  I
    7. 2018
  7. Peters,V., Zschocke,J. and Schmitt,C.P.<br>Carnosinase, diabetes mellitus and the potential relevance of carnosinase deficiency<br>J Inherit Metab Dis (2018) 41, 39-47. PubMed  Europe PubMed DOI  M
    8. 2017
  8. Guilherme,J.P.L.F. and Lancha AH Jr<br>Single nucleotide polymorphisms in carnosinase genes (CNDP1 and CNDP2) are associated with power athletic status<br>Int J Sport Nutr Exerc Metab (2017) 27, 533-542. PubMed  Europe PubMed DOI  M
    9. 2016
  9. Pavlin,M., Rossetti,G., De Vivo,M. and Carloni,P.<br>Carnosine and homocarnosine degradation mechanisms by the human carnosinase enzyme CN1: insights from multiscale simulations<br>Biochemistry (2016) 55, 2772-2784. PubMed  Europe PubMed DOI  I
  10. Zhang,S., Lindner,H.A., Kabtni,S., Van den Born,J., Bakker,S., Navis,G., Kramer,B., Yard,B. and Hauske,S.<br>Monoclonal antibody RYSK173 recognizes the dinuclear Zn center of serum carnosinase 1 (CN-1): possible consequences of Zn binding for CN-1 recognition by RYSK173<br>PLoS ONE (2016) 11, e0146831-e0146831. PubMed  Europe PubMed DOI  PMC  EPMC  M
    11. 2015
  11. Alkhalaf,A., Landman,G.W., van Hateren,K.J., Groenier,K.H., Mooyaart,A.L., de Heer,E., Gans,R.O., Navis,G.J., Bakker,S.J., Kleefstra,N. and Bilo,H.J.<br>Sex specific association between carnosinase gene CNDP1 and cardiovascular mortality in patients with type 2 diabetes (ZODIAC-22)<br>J Nephrol (2015) 28, 201-207. PubMed  Europe PubMed DOI  M
    12. 2013
  12. Zhu,J.M., Wang,B., Li,J., Chen,G.M., Fan,Y.G., Feng,C.C., Pan,H.F. and Ye,D.Q.<br>D18S880 microsatellite polymorphism of carnosinase gene and diabetic nephropathy: A meta-analysis<br>Genet Test Mol Biomarkers (2013) 17, 289-294. PubMed  Europe PubMed DOI  M
    13. 2012
  13. Adelmann,K., Frey,D., Riedl,E., Koeppel,H., Pfister,F., Peters,V., Schmitt,C.P., Sternik,P., Hofmann,S., Zentgraf,H.W., Navis,G., Van den Born,J., Bakker,S.J., Kramer,B.K., Yard,B.A. and Hauske,S.J.<br>Different conformational forms of serum carnosinase detected by a newly developed sandwich ELISA for the measurements of carnosinase concentrations<br>Amino Acids (2012) 43, 143-151. PubMed  Europe PubMed DOI
  14. Everaert,I., Taes,Y., de Heer,E., Baelde,H., Zutinic,A., Yard,B., Sauerhofer,S., Vanhee,L., Delanghe,J., Aldini,G. and Derave,W.<br>Low plasma carnosinase activity promotes carnosinemia after carnosine ingestion in humans<br>Am J Physiol Renal Physiol (2012) 302, F1537-F1544. PubMed  Europe PubMed DOI  M
  15. Jackson,M.C.<br>Carnosine dipeptidase I<br>[ISSN:978-0-12-407743-0] (2012) 3, 1592-1596. DOI
  16. Kilis-Pstrusinska,K.<br>[Carnosine, carnosinase and kidney diseases]<br>Postepy Hig Med Dosw (Online) (2012) 66, 215-221. PubMed  Europe PubMed  V
  17. Oku,T., Ando,S., Tsai,H.C., Yamashita,Y., Ueno,H., Shiozaki,K., Nishi,R. and Yamada,S.<br>Purification and identification of two carnosine-cleaving enzymes, carnosine dipeptidase I and Xaa-methyl-His dipeptidase, from Japanese eel (Anguilla japonica)<br>Biochimie (2012) 94, 1281-1290. PubMed  Europe PubMed DOI
    18. 2011
  18. Chakkera,H.A., Hanson,R.L., Kobes,S., Millis,M.P., Nelson,R.G., Knowler,W.C. and Distefano,J.K.<br>Association of variants in the carnosine peptidase 1 gene (CNDP1) with diabetic nephropathy in American Indians<br>Mol Genet Metab (2011) 103, 185-190. PubMed  Europe PubMed DOI  M
  19. Lanza,V., Bellia,F., D'Agata,R., Grasso,G., Rizzarelli,E. and Vecchio,G.<br>New glycoside derivatives of carnosine and analogs resistant to carnosinase hydrolysis: synthesis and characterization of their copper(II) complexes<br>J Inorg Biochem (2011) 105, 181-188. PubMed  Europe PubMed DOI
    20. 2010
  20. Inaba,C., Higuchi,S., Morisaka,H., Kuroda,K. and Ueda,M.<br>Synthesis of functional dipeptide carnosine from nonprotected amino acids using carnosinase-displaying yeast cells<br>Appl Microbiol Biotechnol (2010) 86, 1895-1902. PubMed  Europe PubMed DOI  E
  21. Kilis-Pstrusinska,K., Zwolinska,D. and Grzeszczak,W.<br>Is carnosinase 1 gene (CNDP1) polymorphism associated with chronic kidney disease progression in children and young adults? Results of a family-based study<br>Arch Med Res (2010) 41, 356-362. PubMed  Europe PubMed DOI  M
  22. Peters,V., Kebbewar,M., Jansen,E.W., Jakobs,C., Riedl,E., Koeppel,H., Frey,D., Adelmann,K., Klingbeil,K., Mack,M., Hoffmann,G.F., Janssen,B., Zschocke,J. and Yard,B.A.<br>Relevance of allosteric conformations and homocarnosine concentration on carnosinase activity<br>Amino Acids (2010) 38, 1607-1615. PubMed  Europe PubMed DOI
  23. Poon,P.Y.K., Szeto,C.C., Kwan,B.C.H., Chow,K.M. and Li,P.K.T.<br>Relationship between carnosinase gene CNDP1 leucine repeat polymorphism and the clinical outcome of Chinese PD patients<br>Clin Nephrol (2010) 74, 343-345. PubMed  Europe PubMed  M
  24. Riedl,E., Koeppel,H., Pfister,F., Peters,V., Sauerhoefer,S., Sternik,P., Brinkkoetter,P., Zentgraf,H., Navis,G., Henning,R.H., Van den Born,J., Bakker,S.J., Janssen,B., van der Woude,F.J. and Yard,B.A.<br>N-Glycosylation of carnosinase influences protein secretion and enzyme activity: implications for hyperglycemia<br>Diabetes (2010) 59, 1984-1990. PubMed  Europe PubMed DOI
    25. 2009
  25. Bellia,F., Calabrese,V., Guarino,F., Cavallaro,M., Cornelius,C., De Pinto,V. and Rizzarelli,E.<br>Carnosinase Levels in Aging Brain: Redox State Induction and Cellular Stress Response<br>Antioxid Redox Signal (2009) 11, 2759-2775. PubMed  Europe PubMed DOI
  26. McDonough,C.W., Hicks,P.J., Lu,L., Langefeld,C.D., Freedman,B.I. and Bowden,D.W.<br>The influence of carnosinase gene polymorphisms on diabetic nephropathy risk in African-Americans<br>Hum Genet (2009) 126, 265-275. PubMed  Europe PubMed DOI  M
    27. 2008
  27. Wanic,K., Placha,G., Dunn,J., Smiles,A., Warram,J.H. and Krolewski,A.S.<br>Exclusion of polymorphisms in carnosinase genes (CNDP1 and CNDP2) as a cause of diabetic nephropathy in type 1 diabetes: results of large case-control and follow-up studies<br>Diabetes (2008) 57, 2547-2551. PubMed  Europe PubMed DOI  PMC  EPMC  M
    28. 2007
  28. Freedman,B.I., Hicks,P.J., Sale,M.M., Pierson,E.D., Langefeld,C.D., Rich,S.S., Xu,J., McDonough,C., Janssen,B., Yard,B.A., van der Woude,F.J. and Bowden,D.W.<br>A leucine repeat in the carnosinase gene CNDP1 is associated with diabetic end-stage renal disease in European Americans<br>Nephrol Dial Transplant (2007) 22, 1131-1135. PubMed  Europe PubMed DOI  M
  29. Riedl,E., Koeppel,H., Brinkkoetter,P., Sternik,P., Steinbeisser,H., Sauerhoefer,S., Janssen,B., van der Woude,F.J. and Yard,B.A.<br>A CTG polymorphism in the CNDP1 gene determines the secretion of serum carnosinase in Cos-7 transfected cells<br>Diabetes (2007) 56, 2410-2413. PubMed  Europe PubMed DOI  M
  30. Sauerhofer,S., Yuan,G., Braun,G.S., Deinzer,M., Neumaier,M., Gretz,N., Floege,J., Kriz,W., van der Woude,F. and Moeller,M.J.<br>L-carnosine, a substrate of carnosinase-1, influences glucose metabolism<br>Diabetes (2007) 56, 2425-2432. PubMed  Europe PubMed DOI
    31. 2006
  31. [YEAR:1-6-2006]Vistoli,G., Pedretti,A., Cattaneo,M., Aldini,G. and Testa,B.<br>Homology modeling of human serum carnosinase, a potential medicinal target, and MD simulations of its allosteric activation by citrate<br>J Med Chem (1-6-2006) 49, 3269-3277. PubMed  Europe PubMed DOI
    32. 2005
  32. Janssen,B., Hohenadel,D., Brinkkoetter,P., Peters,V., Rind,N., Fischer,C., Rychlik,I., Cerna,M., Romzova,M., de Heer,E., Baelde,H., Bakker,S.J., Zirie,M., Rondeau,E., Mathieson,P., Saleem,M.A., Meyer,J., Koppel,H., Sauerhoefer,S., Bartram,C.R., Nawroth,P., Hammes,H.P., Yard,B.A., Zschocke,J. and van der Woude,F.J.<br>Carnosine as a protective factor in diabetic nephropathy: association with a leucine repeat of the carnosinase gene CNDP1<br>Diabetes (2005) 54, 2320-2327. PubMed  Europe PubMed DOI  M
  33. Otani,H., Okumura,N., Hashida-Okumura,A. and Nagai,K.<br>Identification and characterization of a mouse dipeptidase that hydrolyzes L-carnosine<br>J Biochem (2005) 137, 167-175. PubMed  Europe PubMed DOI
    34. 2004
  34. Jackson,M.C.<br>beta-Ala-His dipeptidase<br>[ISSN:0-12-079610-4] (2004) 2, 1024-1026.  V
    35. 2003
  35. Schoen,P., Everts,H., de Boer,T. and van Oeveren,W.<br>Serum carnosinase activity in plasma and serum: validation of a method and values in cardiopulmonary bypass surgery<br>Clin Chem (2003) 49, 1930-1932. PubMed  Europe PubMed DOI
  36. [YEAR:21-2-2003]Teufel,M., Saudek,V., Ledig,J.P., Bernhardt,A., Boularand,S., Carreau,A., Cairns,N.J., Carter,C., Cowley,D.J., Duverger,D., Ganzhorn,A.J., Guenet,C., Heintzelmann,B., Laucher,V., Sauvage,C. and Smirnova,T.<br>Sequence identification and characterization of human carnosinase and a closely related non-specific dipeptidase<br>J Biol Chem (21-2-2003) 278, 6521-6531. PubMed  Europe PubMed DOI
    37. 2001
  37. Baslow,M.H., Suckow,R.F., Berg,M.J., Marks,N., Saito,M. and Bhakoo,K.K.<br>Differential expression of carnosine, homocarnosine and N-acetyl-L-histidine hydrolytic activities in cultured rat macroglial cells<br>J Mol Neurosci (2001) 17, 351-359. PubMed  Europe PubMed DOI
    38. 1997
  38. Willi,S.M., Zhang,Y., Hill,J.B., Phelan,M.C., Michaelis,R.C. and Holden,K.R.<br>A deletion in the long arm of chromosome 18 in a child with serum carnosinase deficiency<br>Pediatr Res (1997) 41, 210-213. PubMed  Europe PubMed DOI
    39. 1994
  39. Jackson,M.C., Scollard,D.M., Mack,R.J. and Lenney,J.F.<br>Localization of a novel pathway for the liberation of GABA in the human CNS<br>Brain Res Bull (1994) 33, 379-385. PubMed  Europe PubMed DOI
  40. Wassif,W.S., Sherwood,R.A., Amir,A., Idowu,B., Summers,B., Leigh,N. and Peters,T.J.<br>Serum carnosinase activities in central nervous system disorders<br>Clin Chim Acta (1994) 225, 57-64. PubMed  Europe PubMed DOI
    41. 1992
  41. Jackson,M.C. and Lenney,J.F.<br>Homocarnosinosis patients and great apes have a serum protein that cross-reacts with human serum carnosinase<br>Clin Chim Acta (1992) 205, 109-116. PubMed  Europe PubMed
    42. 1991
  42. Jackson,M.C., Kucera,C.M. and Lenney,J.F.<br>Purification and properties of human serum carnosinase<br>Clin Chim Acta (1991) 196, 193-205. PubMed  Europe PubMed DOI
    43. 1990
  43. Lenney,J.F.<br>Separation and characterization of two carnosine-splitting cytosolic dipeptidases from hog kidney (carnosinase and non-specific dipeptidase)<br>Biol Chem Hoppe Seyler (1990) 371, 433-440. PubMed  Europe PubMed
    44. 1985
  44. Cohen,M., Hartlage,P.L., Krawiecki,N., Roesel,R.A., Carter,A.L. and Hommes,F.A.<br>Serum carnosinase deficiency: a non-disabling phenotype?<br>J Ment Defic Res (1985) 29, 383-389. PubMed  Europe PubMed  M
    45. 1984
  45. Bando,K., Shimotsuji,T., Toyoshima,H., Hayashi,C. and Miyai,K.<br>Fluorometric assay of human serum carnosinase activity in normal children, adults and patients with myopathy<br>Ann Clin Biochem (1984) 21, 510-514. PubMed  Europe PubMed  A
    46. 1982
  46. [YEAR:18-8-1982]Lenney,J.F., George,R.P., Weiss,A.M., Kucera,C.M., Chan,P.W. and Rinzler,G.S.<br>Human serum carnosinase: characterization, distinction from cellular carnosinase, and activation by cadmium<br>Clin Chim Acta (18-8-1982) 123, 221-231. PubMed  Europe PubMed DOI
    47. 1979
  47. [YEAR:7-9-1979]Harding,J.W. and O'Fallon,J.V.<br>The subcellular distribution of carnosine, carnosine synthetase, and carnosinase in mouse olfactory tissues<br>Brain Res (7-9-1979) 173, 99-109. PubMed  Europe PubMed DOI
  48. [YEAR:11-10-1979]Margolis,F.L., Grillo,M., Brown,C.E., Williams,T.H., Pitcher,R.G. and Elgar,G.J.<br>Enzymatic and immunological evidence for two forms of carnosinase in the mouse<br>Biochim Biophys Acta (11-10-1979) 570, 311-323. PubMed  Europe PubMed
    49. 1978
  49. Wolos,A., Piekarska,K., Glogowski,J. and Konieczka,I.<br>Two molecular forms of swine kidney carnosinase<br>Int J Biochem (1978) 9, 57-62. PubMed  Europe PubMed
    50. 1976
  50. [YEAR:11-3-1976]Lenney,J.F.<br>Specificity and distribution of mammalian carnosinase<br>Biochim Biophys Acta (11-3-1976) 429, 214-219. PubMed  Europe PubMed  P
  51. Sjaastad,O., Berstad,J., Gjesdahl,P. and Gjessing,L.<br>Homocarnosinosis. 2. A familial metabolic disorder associated with spastic paraplegia, progressive mental deficiency, and retinal pigmentation<br>Acta Neurol Scand (1976) 53, 275-290. PubMed  Europe PubMed  K
    52. 1975
  52. [YEAR:2-6-1975]Burgess,E.A., Oberholzer,V.G., Palmer,T. and Levin,B.<br>Plasma carnosinase deficiency in patients with urea cycle defects<br>Clin Chim Acta (2-6-1975) 61, 215-218. PubMed  Europe PubMed
    53. 1972
  53. Murphey,W.H., Patchen,L. and Lindmark,D.G.<br>Carnosinase: a fluorometric assay and demonstration of two electrophoretic forms in human tissue extracts<br>Clin Chim Acta (1972) 42, 309-314.  A
    54. 1960
  54. [YEAR:4-12-1960]Rosenberg,A.<br>The activation of carnosinase by divalent metal ions<br>Biochim Biophys Acta (4-12-1960) 45, 297-316. PubMed  Europe PubMed
  55. Rosenberg,A.<br>Purification and some properties of carnosinase of swine kidney<br>Arch Biochem Biophys (1960) 88, 83-93. PubMed  Europe PubMed
    56. 1956
  56. Davis,N.C.<br>Action of proteolytic enzymes on some peptides and derivatives containing histidine<br>J Biol Chem (1956) 223, 935-947. PubMed  Europe PubMed  P
    57. 1955
  57. Smith,E.L.<br>[10] Dipeptidases<br>Methods Enzymol (1955) 2, 93-109. DOI  V
    58. 1937
  58. Du Vigneaud,V., Sifferd,R.H. and Irving,G.W., Jr.<br>The utilization of l-carnosine by animals on a histidine-deficient diet<br>J Biol Chem (1937) 117, 589-597.

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