$VAR1 = undef;

Summary for peptidase M20.006: carnosine dipeptidase I

Names
MEROPS Name	carnosine dipeptidase I
Other names	beta-Ala-His dipeptidase (mammal), carnosinase CN1, CNDP1 g.p. (Homo sapiens), CPGL2 putative peptidase, Mername-AA104 peptidase, plasma carnosinase, serum carnosinase

Domain architecture

MEROPS Classification
Classification	Clan MH >> Subclan (none) >> Family M20 >> Subfamily F >> M20.006
Holotype	carnosine dipeptidase I (Homo sapiens), Uniprot accession Q96KN2 (peptidase unit: 3-507), MERNUM MER0015142
History	Identifier created: MEROPS 5.61 (29 October 2001)

Activity
Catalytic type	Metallo
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.13 (Dipeptidases) >> Peptidase 3.4.13.20
Enzymology	BRENDA database
Activity status	human: active (Jackson, 2004) mouse: active (Margolis et al., 1979)
Physiology	Hydrolyses carnosine extracellularly. Diabetic nephropathy is linked to the CNDP1 gene (Janssen et al., 2005; Freedman et al., 2007).
Pharmaceutical relevance	Deficiency leads to homocarnosinosis.
Pathways	KEGG	Arginine and proline metabolism
	KEGG	beta-Alanine metabolism
	KEGG	Histidine metabolism
Other databases	TREEFAM	http://www.treefam.org/family/TF300633
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/-/-/Aghal/-/-/- (based on 17 cleavages)

Specificity matrix

Amino acid	P1	P1'	P2'
Gly	5	1	1
Pro	0	0	0
Ala	8	3	0
Val	0	0	0
Leu	1	3	0
Ile	0	0	0
Met	0	0	0
Phe	1	1	0
Tyr	0	1	0
Trp	0	0	0
Ser	1	0	0
Thr	0	0	0
Cys	0	0	0
Asn	0	0	0
Gln	0	0	0
Asp	0	0	0
Glu	0	0	0
Lys	0	0	1
Arg	0	0	0
His	0	8	0