Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Literature for peptidase C65.001: otubain-1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, P Specificity, I Inhibitor, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Ai,S., Pan,J., Liu,Q., Tang,F., Wen,T., Yuan,Y., He,Q. and Huang,L.
    OTUB1 mediates PARP1 deubiquitination to alleviate NAFLD by regulating HMGB1
    Exp Cell Res (2025) 445, 114425-114425. PubMed  Europe PubMed DOI
  2. Fan,A., Zhang,Y., Li,Y., Meng,W., Wu,F., Pan,W., Ma,Z. and Chen,W.
    Primary Cilia Formation Mediated by Hsa_Circ_0005185/OTUB1/RAB8A Complex Inhibits Prostate Cancer Progression by Suppressing Hedgehog Signaling Pathway
    Adv Sci (Weinh) (2025) , e2411675-e2411675. PubMed  Europe PubMed DOI
  3. Hong,L., Ye,T., Wang,T.Z., Srijay,D., Liu,H., Zhao,L., Watson,R., Vincoff,S., Chen,T., Kholina,K., Goel,S., DeLisa,M.P. and Chatterjee,P.
    Programmable protein stabilization with language model-derived peptide guides
    Nat Commun (2025) 16, 3555-3555. PubMed  Europe PubMed DOI  PMC  EPMC
  4. Lin,M., Li,G., Tang,X., Li,R., Li,Y., Wang,L., Xu,Z., Liu,L., Ju,E., Shang,J., He,S. and Li,T.
    A viral Cyclin D homolog protein hijacks the metabolic stress sensor SESN2 to promote primary effusion lymphoma growth
    Proc Natl Acad Sci U S A (2025) 122, e2520925122-e2520925122. PubMed  Europe PubMed DOI  PMC  EPMC
  5. Lv,D., Ren,L., Zhao,Z., Rong,Y., Chen,M., Yang,H., Yin,R., Zeng,R., Chao,H., Li,X., Xu,Z., Hu,Z., Cao,X., Deng,W., Tang,Q. and Tang,B.
    A biomimetic senotherapy replenishing MAT2A promotes wound regeneration in preclinical models
    Nat Commun (2025) 16, 10580-10580. PubMed  Europe PubMed DOI  PMC  EPMC
  6. Sun,C., Cai,S., Yang,J., Du,M., Pan,Q., Wang,Y., Sun,W., Bai,M. and Liang,H.
    OTUB1 antagonizes TRIM21 to induce deubiquitination of SPHK1 and promote the progression of hepatocellular carcinoma
    Oncogene (2025) PubMed  Europe PubMed DOI
  7. Wu,Y., Deng,Y., Ai,Q., Li,Y., Qin,F., Hammad,M., Meng,Z., Xu,X., Wei,J., Yu,H., Liang,G. and Zhao,X.
    Deubiquitinating enzymes in parkinson's disease: molecular mechanisms and therapeutic potential
    Mol Med (2025) 31, 329-329. PubMed  Europe PubMed DOI
  8. Zhang,P., Cheng,J., Liu,Z., Adeshakin,F.O., Dai,L., Niu,X., Zhang,Z., Peng,X., Li,L., Liu,M., Yan,D., Yang,X., Wan,X. and Zhang,G.
    NY-ESO-1 facilitates anoikis resistance and tumor metastasis by hijacking deubiquitinase OTUB1 to stabilize PP1alpha
    Cell Death Dis (2025) 16, 682-682. PubMed  Europe PubMed DOI  PMC  EPMC  K
  9. Zhang,W., Liu,R., Hu,J., Wan,S., Zou,Y., Che,T., Zhang,J., Chen,L. and Peng,X.
    The deubiquitylase OTUB1 drives gemcitabine resistance in pancreatic cancer by enhancing pyrimidine metabolism through modulating DHODH mRNA stability
    Cell Death Dis (2025) 16, 697-697. PubMed  Europe PubMed DOI  PMC  EPMC  K
  10. Zhong,X., Li,Y., Xie,Y., Zhang,Y., Wang,M., Jiang,H., Liu,Z., Dai,L., Li,L., Wang,H., Madhusudhan,T., Zeng,H. and Wang,H.
    Targeting the miR-493-5p/OTUB1 axis to mitigate mitochondrial dysfunction in diabetic cardiomyopathy
    Eur J Pharmacol (2025) 1003, 177956-177956. PubMed  Europe PubMed DOI
    11. 2024
  11. Li,S., Yang,M., Zhao,Y., Zhai,Y., Sun,C., Guo,Y., Zhang,X., Zhang,L., Tian,T., Yang,Y., Pei,Y., Li,J., Li,C., Xuan,L., Li,X., Zhao,D., Yang,H., Zhang,Y., Yang,B., Zhang,Z., Pan,Z. and Lu,Y.
    Deletion of ASPP1 in myofibroblasts alleviates myocardial fibrosis by reducing p53 degradation
    Nat Commun (2024) 15, 8425-8425. PubMed  Europe PubMed DOI  PMC  EPMC
  12. Liao,Y., Liang,J., Wang,Y., Li,A., Liu,W., Zhong,B., Wang,K., Zhou,D., Guo,T., Guo,J., Yu,X. and Jiang,N.
    Target deubiquitinase OTUB1 as a therapeatic strategy for BLCA via beta-catenin/necroptosis signal pathway
    Int J Biol Sci (2024) 20, 3784-3801. PubMed  Europe PubMed DOI  PMC  EPMC
  13. Majumder,S., Srivastava,M., Alam,P., Saha,S., Kumari,R., Chand,A.K., Asthana,S., Sen,S. and Maiti,T.K.
    Hotspot site microenvironment in the deubiquitinase OTUB1 drives its stability and aggregation
    J Biol Chem (2024) , 107315-107315. PubMed  Europe PubMed DOI
  14. Xu,F., Zang,T., Chen,H., Zhou,C., Wang,R., Yu,Y., Shen,L., Qian,J. and Ge,J.
    Deubiquitinase OTUB1 regulates doxorubicin-induced cardiotoxicity via deubiquitinating c-MYC
    Cell Signal (2024) 113, 110937-110937. PubMed  Europe PubMed DOI  K
  15. Xue,Y., Xue,C. and Song,W.
    Emerging roles of deubiquitinating enzymes in actin cytoskeleton and tumor metastasis
    Cell Oncol (Dordr) (2024) PubMed  Europe PubMed DOI  V
  16. Yang,J., Zhang,N., He,Z., Xiong,J., Meng,W., Xue,C., Ying,L., Li,M., Liu,M. and Ouyang,T.
    OTUB1 Promotes Glioblastoma Growth by Inhibiting the JAK2/STAT1 Signaling Pathway
    J Cancer (2024) 15, 4566-4576. PubMed  Europe PubMed DOI  PMC  EPMC  K
  17. Zhao,Q., Wang,Q., Li,B., Han,S., Zhang,Y., Wang,Y., Lu,R., Chen,Q., Sun,Z., Ding,M., Liang,Z. and Gao,Y.
    The deubiquitinase OTUB1 inhibits gluconeogenesis by stabilizing YWHAB
    Cell Signal (2024) 124, 111408-111408. PubMed  Europe PubMed DOI
  18. Zhao,X., Lv,S., Li,N., Zou,Q., Sun,L. and Song,T.
    YTHDF2 protein stabilization by the deubiquitinase OTUB1 promotes prostate cancer cell proliferation via PRSS8 mRNA degradation
    J Biol Chem (2024) 300, 107152-107152. PubMed  Europe PubMed DOI  PMC  EPMC
    19. 2023
  19. Aboushousha,R., van der Velden,J., Hamilton,N., Peng,Z., MacPherson,M., Erickson,C., White,S., Wouters,E.F.M., Reynaert,N.L., Seward,D.J., Li,J. and Janssen-Heininger,Y.M.W.
    Glutaredoxin attenuates glutathione levels via deglutathionylation of Otub1 and subsequent destabilization of system x(C)()
    Sci Adv (2023) 9, eadi5192-eadi5192. PubMed  Europe PubMed DOI  PMC  EPMC
  20. Galindo-Hernandez,O., Garcia-Salazar,L.A., Garcia-Gonzalez,V.G., Diaz-Molina,R. and Vique-Sanchez,J.L.
    Potential Inhibitors of The OTUB1 Catalytic Site to Develop an Anti-Cancer Drug Using In-Silico Approaches
    Rep Biochem Mol Biol (2023) 11, 684-693. PubMed  Europe PubMed DOI  PMC  EPMC
  21. Jin,S., Tsunematsu,T., Horiguchi,T., Mouri,Y., Shao,W., Miyoshi,K., Hagita,H., Sarubo,M., Fujiwara,N., Qi,G., Ishimaru,N. and Kudo,Y.
    Involvement of the OTUB1-YAP1 axis in driving malignant behaviors of head and neck squamous cell carcinoma
    Cancer Med (2023) 12, 22156-22169. PubMed  Europe PubMed DOI  PMC  EPMC
  22. Li,D., Wang,Y., Dong,C., Chen,T., Dong,A., Ren,J., Li,W., Shu,G., Yang,J., Shen,W., Qin,L., Hu,L. and Zhou,J.
    CST1 inhibits ferroptosis and promotes gastric cancer metastasis by regulating GPX4 protein stability via OTUB1
    Oncogene (2023) 42, 83-98. PubMed  Europe PubMed DOI  PMC  EPMC
  23. Li,M., Wang,X., Yang,E., Li,Y., Geng,Y., Chen,Z., Huang,S., Zhang,D. and Wu,H.
    OTUB1 Catalytic-Independently Deubiquitinates TGFBI and Mediates the Angiogenesis in Infantile Hemangioma by Regulating Glycolysis
    Arterioscler Thromb Vasc Biol (2023) 43, 654-673. PubMed  Europe PubMed DOI  K
  24. Li,Y., Li,R., Qin,H., He,H. and Li,S.
    OTUB1's role in promoting OSCC development by stabilizing RACK1 involves cell proliferation, migration, invasion, and tumor-associated macrophage M1 polarization
    Cell Signal (2023) 110, 110835-110835. PubMed  Europe PubMed DOI  K
  25. Liu,N., Lin,M.M. and Wang,Y.
    The Emerging Roles of E3 Ligases and DUBs in Neurodegenerative Diseases
    Mol Neurobiol (2023) 60, 247-263. PubMed  Europe PubMed DOI  PMC  EPMC  V
  26. Seo,S.U., Woo,S.M. and Kwon,T.K.
    Cathepsin K inhibition induces Raptor destabilization and mitochondrial dysfunction via Syk/SHP2/Src/OTUB1 axis-mediated signaling
    Cell Death Dis (2023) 14, 366-366. PubMed  Europe PubMed DOI  PMC  EPMC  K
  27. Shang,L., Du,Y., Zhao,Y., Zhang,Y. and Liu,C.
    The Interaction of OTUB1 and TRAF3 Mediates NLRP3 Inflammasome Activity to Regulate TGF-beta1-induced BEAS-2B Cell Injury
    Appl Biochem Biotechnol (2023) 195, 7060-7074. PubMed  Europe PubMed DOI  K
  28. Sheryazdanova,A., Amoedo,N.D., Dufour,S., Impens,F., Rossignol,R. and Sablina,A.
    The deubiquitinase OTUB1 governs lung cancer cell fitness by modulating proteostasis of OXPHOS proteins
    Biochim Biophys Acta Mol Basis Dis (2023) 1869, 166767-166767. PubMed  Europe PubMed DOI
  29. Sorada,T., Morimoto,D., Walinda,E. and Sugase,K.
    Corrigendum to "Molecular recognition and deubiquitination of cyclic K48-linked ubiquitin chains by OTUB1" [Biochem. Biophys. Res. Commun. 562 (2021) 94-99]
    Biochem Biophys Res Commun (2023) 660, 100-100. PubMed  Europe PubMed DOI
  30. Xing,X., Xu,F., Wang,Y. and Liu,H.
    Role of the OTUB1/IRF7/NOX4 axis in oxidative stress injury and inflammatory responses in mice with Parkinson's disease
    Psychogeriatrics (2023) 23, 32-44. PubMed  Europe PubMed DOI
  31. Zhang,W., Qian,W., Gu,J., Gong,M., Zhang,W., Zhang,S., Zhou,C., Jiang,Z., Jiang,J., Han,L., Wang,X., Wu,Z., Ma,Q. and Wang,Z.
    Mutant p53 driven-LINC00857, a protein scaffold between FOXM1 and deubiquitinase OTUB1, promotes the metastasis of pancreatic cancer
    Cancer Lett (2023) 552, 215976-215976. PubMed  Europe PubMed DOI
  32. Zhao,Y., Ruan,J., Li,Z., Su,X., Chen,K., Lin,Y., Cai,Y., Wang,P., Liu,B., Schluter,D., Liang,G. and Wang,X.
    OTUB1 inhibits breast cancer by non-canonically stabilizing CCN6
    Clin Transl Med (2023) 13, e1385-e1385. PubMed  Europe PubMed DOI  PMC  EPMC
  33. Zhu,Q., Fu,Y., Cui,C.P., Ding,Y., Deng,Z., Ning,C., Hu,F., Qiu,C., Yu,B., Zhou,X., Yang,G., Peng,J., Zou,W., Liu,C.H. and Zhang,L.
    OTUB1 promotes osteoblastic bone formation through stabilizing FGFR2
    Signal Transduct Target Ther (2023) 8, 142-142. PubMed  Europe PubMed DOI  PMC  EPMC
    34. 2022
  34. Han,X., Ren,C., Lu,C., Qiao,P., Yang,T. and Yu,Z.
    Deubiquitination of MYC by OTUB1 contributes to HK2 mediated glycolysis and breast tumorigenesis
    Cell Death Differ (2022) 29, 1864-1873. PubMed  Europe PubMed DOI
  35. Henning,N.J., Boike,L., Spradlin,J.N., Ward,C.C., Liu,G., Zhang,E., Belcher,B.P., Brittain,S.M., Hesse,M.J., Dovala,D., McGregor,L.M., Valdez Misiolek,R., Plasschaert,L.W., Rowlands,D.J., Wang,F., Frank,A.O., Fuller,D., Estes,A.R., Randal,K.L., Panidapu,A., McKenna,J.M., Tallarico,J.A., Schirle,M. and Nomura,D.K.
    Deubiquitinase-targeting chimeras for targeted protein stabilization
    Nat Chem Biol (2022) 18, 412-421. PubMed  Europe PubMed DOI
  36. Kumari,R., Kumar,R., Dey,A.K., Saha,S. and Maiti,T.K.
    S-Nitrosylation of OTUB1 Alters Its Stability and Ubc13 Binding
    ACS Chem Neurosci (2022) 13, 1517-1525. PubMed  Europe PubMed DOI
  37. Lin,F., Chen,W., Zhou,J., Zhu,J., Yao,Q., Feng,B., Feng,X., Shi,X., Pan,Q., Yu,J., Li,L. and Cao,H.
    Mesenchymal stem cells protect against ferroptosis via exosome-mediated stabilization of SLC7A11 in acute liver injury
    Cell Death Dis (2022) 13, 271-271. PubMed  Europe PubMed DOI  PMC  EPMC
  38. Ling,X., Lu,J., Wang,X., Liu,L., Liu,L., Wang,Y., Sun,Y., Ren,C., Lu,C. and Yu,Z.
    Ovarian tumorB1-mediated heat shock transcription factor 1 deubiquitination is critical for glycolysis and development of endometriosis
    iScience (2022) 25, 105363-105363. PubMed  Europe PubMed DOI  PMC  EPMC
  39. Liu,J., Yu,X., Chen,H., Kaniskan,H.U., Xie,L., Chen,X., Jin,J. and Wei,W.
    TF-DUBTACs Stabilize Tumor Suppressor Transcription Factors
    J Am Chem Soc (2022) 144, 12934-12941. PubMed  Europe PubMed DOI
  40. Stutz,A., Nishanth,G., Zenclussen,A.C. and Schumacher,A.
    Partial otubain 1 deficiency compromises fetal well-being in allogeneic pregnancies despite no major changes in the dendritic cell and T cell compartment
    BMC Res Notes (2022) 15, 341-341. PubMed  Europe PubMed DOI  PMC  EPMC
  41. Tan,L., Shan,H., Han,C., Zhang,Z., Shen,J., Zhang,X., Xiang,H., Lu,K., Qi,C., Li,Y., Zhuang,G., Chen,G. and Tan,L.
    Discovery of Potent OTUB1/USP8 Dual Inhibitors Targeting Proteostasis in Non-Small-Cell Lung Cancer
    J Med Chem (2022) 65, 13645-13659. PubMed  Europe PubMed DOI  K  I
  42. Wang,S., Wang,Y., Li,Q., Li,X. and Feng,X.
    A novel circular RNA confers trastuzumab resistance in human epidermal growth factor receptor 2-positive breast cancer through regulating ferroptosis
    Environ Toxicol (2022) PubMed  Europe PubMed DOI  K
  43. Yan,C., Yang,H., Su,P., Li,X., Li,Z., Wang,D., Zang,Y., Wang,T., Liu,Z., Bao,Z., Dong,S., Zhuang,T., Zhu,J. and Ding,Y.
    OTUB1 suppresses Hippo signaling via modulating YAP protein in gastric cancer
    Oncogene (2022) 41, 5186-5198. PubMed  Europe PubMed DOI  PMC  EPMC  K
  44. Ye,D., Wang,S., Wang,X., Lin,Y., Huang,Y. and Chi,P.
    Overexpression of OTU domain-containing ubiquitin aldehyde-binding protein 1 exacerbates colorectal cancer malignancy by inhibiting protein degradation of beta-Catenin via Ubiquitin-proteasome pathway
    Bioengineered (2022) 13, 9106-9116. PubMed  Europe PubMed DOI
  45. Zhang,J.L., Du,B.B., Zhang,D.H., Li,H., Kong,L.Y., Fan,G.J., Li,Y.P., Li,P.C., Liang,C., Wang,Z., Yang,L.L., Hao,Z.Y., Wu,L.M., Huang,Z., Dong,J.Z., Zhang,J.Y., Yao,R., Wang,S.J. and Zhang,Y.Z.
    OTUB1 Alleviates Nonalcoholic Steatosis through Inhibition of the TRAF6-ASK1 Signaling Pathways
    Hepatology (2022) 75, 1218-1234. PubMed  Europe PubMed DOI
  46. Zhong,X., Wang,T., Zhang,W., Wang,M., Xie,Y., Dai,L., He,X., Madhusudhan,T., Zeng,H. and Wang,H.
    ERK/RSK-mediated phosphorylation of Y-box binding protein-1 aggravates diabetic cardiomyopathy by suppressing its interaction with deubiquitinase OTUB1
    J Biol Chem (2022) 298, 101989-101989. PubMed  Europe PubMed DOI  PMC  EPMC
    47. 2021
  47. Jiang,D.J., Hao,X.H., Zhang,J., Tang,H. and Wang,F.
    Reducing expression of TaOTUB1s decreases tiller number in wheat
    Plant Signal Behav (2021) 16, 2018217-2018217. PubMed  Europe PubMed DOI
  48. Kim,S., Park,K., Oh,J.M. and Kim,H.
    RNF126 is a positive regulator of TRAF3 ubiquitination
    Biosci Biotechnol Biochem (2021) PubMed  Europe PubMed DOI
  49. Koschel,J., Nishanth,G., Just,S., Harit,K., Kroger,A., Deckert,M., Naumann,M. and Schluter,D.
    OTUB1 prevents lethal hepatocyte necroptosis through stabilization of c-IAP1 during murine liver inflammation
    Cell Death Differ (2021) PubMed  Europe PubMed DOI
  50. Lee,B.S., Kang,S.U., Huang,M., Kim,Y.S., Lee,Y.S., Park,J.Y. and Kim,C.H.
    OTUB1 knockdown promotes apoptosis in melanoma cells by upregulating TRAIL expression
    BMB Rep (2021) PubMed  Europe PubMed
  51. Liu,Z., Wang,T., She,Y., Wu,K., Gu,S., Li,L., Dong,C., Chen,C. and Zhou,Y.
    N(6)-methyladenosine-modified circIGF2BP3 inhibits CD8(+) T-cell responses to facilitate tumor immune evasion by promoting the deubiquitination of PD-L1 in non-small cell lung cancer
    Mol Cancer (2021) 20, 105-105. PubMed  Europe PubMed DOI  PMC  EPMC
  52. Sivakumar,D. and Stein,M.
    Binding of SARS-CoV Covalent Non-Covalent Inhibitors to the SARS-CoV-2 Papain-Like Protease and Ovarian Tumor Domain Deubiquitinases
    Biomolecules (2021) 11 PubMed  Europe PubMed DOI  PMC  EPMC
  53. Sorada,T., Morimoto,D., Walinda,E. and Sugase,K.
    Molecular recognition and deubiquitination of cyclic K48-linked ubiquitin chains by OTUB1
    Biochem Biophys Res Commun (2021) 562, 94-99. PubMed  Europe PubMed DOI
  54. Sun,T., Xu,Y., Xu,Z., Cao,B., Zhang,Z., Wang,Q., Kong,Y. and Mao,X.
    Inhibition of the Otub1/c-Maf axis by the herbal acevaltrate induces myeloma cell apoptosis
    Cell Commun Signal (2021) 19, 24-24. PubMed  Europe PubMed DOI  PMC  EPMC
  55. Weber,E., Schorpp,K. and Hadian,K.
    Studying OTUD6B-OTUB1 Protein-Protein Interaction by Low-Throughput GFP-Trap Assays and High-Throughput AlphaScreen Assays
    Methods Mol Biol (2021) 2261, 381-394. PubMed  Europe PubMed DOI
  56. Wu,Q., Huang,Y., Gu,L., Chang,Z. and Li,G.M.
    OTUB1 stabilizes mismatch repair protein MSH2 by blocking ubiquitination
    J Biol Chem (2021) , 100466-100466. PubMed  Europe PubMed DOI
  57. Xu,Y., Xu,M., Tong,J., Tang,X., Chen,J., Chen,X., Zhang,Z., Cao,B., Stewart,A.K., Moran,M.F., Wu,D. and Mao,X.
    Targeting the Otub1/c-Maf axis for the treatment of multiple myeloma
    Blood (2021) 137, 1478-1490. PubMed  Europe PubMed DOI
  58. Zhang,H.H., Li,C., Ren,J.W., Liu,L., Du,X.H., Gao,J., Liu,T. and Li,S.Z.
    OTUB1 facilitates bladder cancer progression by stabilizing ATF6 in response to ER stress
    Cancer Sci (2021) 112, 2199-2209. PubMed  Europe PubMed DOI
  59. Zhang,Y., Zhu,Y., Xiao,M., Cheng,Y., He,D., Liu,J., Xiang,L., Gong,L., Wang,Z., Deng,L. and Cao,K.
    The Long Non-coding RNA TMPO-AS1 Promotes Bladder Cancer Growth and Progression via OTUB1-Induced E2F1 Deubiquitination
    Front Oncol (2021) 11, 643163-643163. PubMed  Europe PubMed DOI  PMC  EPMC  K
  60. Zhao,X., Zhou,M., Yang,Y. and Luo,M.
    The ubiquitin hydrolase OTUB1 promotes glioma cell stemness via suppressing ferroptosis through stabilizing SLC7A11 protein
    Bioengineered (2021) 12, 12636-12645. PubMed  Europe PubMed DOI  K
  61. Zhu,D., Xu,R., Huang,X., Tang,Z., Tian,Y., Zhang,J. and Zheng,X.
    Deubiquitinating enzyme OTUB1 promotes cancer cell immunosuppression via preventing ER-associated degradation of immune checkpoint protein PD-L1
    Cell Death Differ (2021) 28, 1773-1789. PubMed  Europe PubMed DOI
  62. Zhu,Q., Fu,Y., Li,L., Liu,C.H. and Zhang,L.
    The functions and regulation of Otubains in protein homeostasis and diseases
    Ageing Res Rev (2021) 67, 101303-101303. PubMed  Europe PubMed DOI  V
    63. 2020
  63. Kumari,R., Kumar,R., Kumar,S., Singh,A.K., Hanpude,P., Jangir,D. and Maiti,T.K.
    Amyloid aggregates of the deubiquitinase OTUB1 are neurotoxic, suggesting that they contribute to the development of Parkinson's disease
    J Biol Chem (2020) 295, 3466-3484. PubMed  Europe PubMed DOI
  64. Liao,Y., Wu,N., Wang,K., Wang,M., Wang,Y., Gao,J., Zhong,B., Ma,F., Wu,Y. and Jiang,N.
    OTUB1 Promotes Progression and Proliferation of Prostate Cancer via Deubiquitinating and Stabling Cyclin E1
    Front Cell Dev Biol (2020) 8, 617758-617758. PubMed  Europe PubMed DOI  PMC  EPMC
  65. Sivakumar,D., Kumar,V., Naumann,M. and Stein,M.
    Activation and selectivity of OTUB-1 and OTUB-2 deubiquitinylases
    J Biol Chem (2020) 295, 6972-6982. PubMed  Europe PubMed DOI
  66. Zhang,W. and Qiu,W.
    OTUB1 Recruits Tumor Infiltrating Lymphocytes and Is a Prognostic Marker in Digestive Cancers
    Front Mol Biosci (2020) 7, 212-212. PubMed  Europe PubMed DOI  PMC  EPMC
  67. Zhou,K., Mai,H., Zheng,S., Cai,W., Yang,X., Chen,Z. and Zhan,B.
    OTUB1-mediated deubiquitination of FOXM1 up-regulates ECT-2 to promote tumor progression in renal cell carcinoma
    Cell Biosci (2020) 10, 50-50. PubMed  Europe PubMed DOI  PMC  EPMC
    68. 2019
  68. Gan,B.
    DUBbing ferroptosis in cancer cells
    Cancer Res (2019) 79, 1749-1750. PubMed  Europe PubMed DOI
  69. Huggins,M.A. and Hamilton,S.E.
    Deubiquitinase Otub1 negatively regulates IL-15 signaling in CD8 T cells and NK cells
    Cell Mol Immunol (2019) 16, 846-847. PubMed  Europe PubMed DOI
  70. Liu,T., Jiang,L., Tavana,O. and Gu,W.
    The deubiquitylase OTUB1 mediates ferroptosis via stabilization of SLC7A11
    Cancer Res (2019) 79, 1913-1924. PubMed  Europe PubMed DOI
  71. Pickel,C., Gunter,J., Ruiz-Serrano,A., Spielmann,P., Fabrizio,J.A., Wolski,W., Peet,D.J., Wenger,R.H. and Scholz,C.C.
    Oxygen-dependent bond formation with FIH regulates the activity of the client protein OTUB1
    Redox Biol (2019) 26, 101265-101265. PubMed  Europe PubMed DOI  PMC  EPMC
  72. Saldana,M., VanderVorst,K., Berg,A.L., Lee,H. and Carraway,K.L.
    Otubain 1: a non-canonical deubiquitinase with an emerging role in cancer
    Endocr Relat Cancer (2019) 26, R1-R1. PubMed  Europe PubMed DOI  PMC  EPMC
  73. Wang,X., Mulas,F., Yi,W., Brunn,A., Nishanth,G., Just,S., Waisman,A., Bruck,W., Deckert,M. and Schluter,D.
    OTUB1 inhibits CNS autoimmunity by preventing IFN-gamma-induced hyperactivation of astrocytes
    EMBO J (2019) 38, e100947-e100947. PubMed  Europe PubMed DOI
  74. Xuan,N.T., Trung,D.M., Minh,N.N., Nghia,V.X., Giang,N.V., Canh,N.X., Toan,N.L., Cam,T.D., Nga,N.T., Tien,T.V. and Hoang,N.H.
    Regulation of p38MAPK-mediated dendritic cell functions by the deubiquitylase otubain 1
    HLA (2019) 93, 462-470. PubMed  Europe PubMed DOI
    75. 2018
  75. Pasupala,N., Morrow,M.E., Que,L.T., Malynn,B.A., Ma,A. and Wolberger,C.
    OTUB1 non-catalytically stabilizes the E2 ubiquitin-conjugating enzyme UBE2E1 by preventing its autoubiquitination
    J Biol Chem (2018) 293, 18285-18295. PubMed  Europe PubMed DOI
  76. Zhao,L., Wang,X., Yu,Y., Deng,L., Chen,L., Peng,X., Jiao,C., Gao,G., Tan,X., Pan,W., Ge,X. and Wang,P.
    OTUB1 protein suppresses mTOR complex 1 (mTORC1) activity by deubiquitinating the mTORC1 inhibitor DEPTOR
    J Biol Chem (2018) 293, 4883-4892. PubMed  Europe PubMed DOI
  77. Zhou,H., Liu,Y., Zhu,R., Ding,F., Cao,X., Lin,D. and Liu,Z.
    OTUB1 promotes esophageal squamous cell carcinoma metastasis through modulating Snail stability
    Oncogene (2018) 37, 3356-3368. PubMed  Europe PubMed DOI
    78. 2014
  78. Sun,X.X. and Dai,M.S.
    Deubiquitinating enzyme regulation of the p53 pathway: a lesson from Otub1
    World J Biol Chem (2014) 5, 75-84. PubMed  Europe PubMed DOI  PMC  EPMC
    79. 2012
  79. Juang,Y.C., Landry,M.C., Sanches,M., Vittal,V., Leung,C.C., Ceccarelli,D.F., Mateo,A.R., Pruneda,J.N., Mao,D.Y., Szilard,R.K., Orlicky,S., Munro,M., Brzovic,P.S., Klevit,R.E., Sicheri,F. and Durocher,D.
    OTUB1 co-opts Lys48-linked ubiquitin recognition to suppress E2 enzyme function
    Mol Cell (2012) 45, 384-397. PubMed  Europe PubMed DOI
  80. Kessler,B.M.
    Otubains
    [ISSN:978-0-12-407743-0] (2012) 3, 2113-2120. DOI
  81. Sato,Y., Yamagata,A., Goto-Ito,S., Kubota,K., Miyamoto,R., Nakada,S. and Fukai,S.
    Molecular basis of Lys-63-linked polyubiquitination inhibition by the interaction between human deubiquitinating enzyme OTUB1 and ubiquitin-conjugating enzyme UBC13
    J Biol Chem (2012) 287, 25860-25868. PubMed  Europe PubMed DOI  S
  82. Sun,X.X., Challagundla,K.B. and Dai,M.S.
    Positive regulation of p53 stability and activity by the deubiquitinating enzyme otubain 1
    EMBO J (2012) 31, 576-592. PubMed  Europe PubMed DOI
    83. 2011
  83. Blackford,A.N. and Stewart,G.S.
    When cleavage is not attractive: non-catalytic inhibition of ubiquitin chains at DNA double-strand breaks by OTUB1
    DNA Repair (Amst) (2011) 10, 245-249. PubMed  Europe PubMed DOI
  84. Yue,M.J., Mo,S.J., Song,P. and Gong,Y.Z.
    Identification of Z-OTU protein during zebrafish oogenesis and early embryogenesis
    Dongwuxue Yanjiu (2011) 32, 386-390. PubMed  Europe PubMed DOI
    85. 2010
  85. Edelmann,M.J., Kramer,H.B., Altun,M. and Kessler,B.M.
    Post-translational modification of the deubiquitinating enzyme otubain 1 modulates active RhoA levels and susceptibility to Yersinia invasion
    FEBS J (2010) 277, 2515-2530. PubMed  Europe PubMed DOI
  86. Li,S., Zheng,H., Mao,A.P., Zhong,B., Li,Y., Liu,Y., Gao,Y., Ran,Y., Tien,P. and Shu,H.B.
    Regulation of virus-triggered signaling by OTUB1- and OTUB2-mediated deubiquitination of TRAF3 and TRAF6
    J Biol Chem (2010) 285, 4291-4297. PubMed  Europe PubMed DOI  PMC  EPMC
  87. Nakada,S., Tai,I., Panier,S., Al-Hakim,A., Iemura,S., Juang,Y.C., O'Donnell,L., Kumakubo,A., Munro,M., Sicheri,F., Gingras,A.C., Natsume,T., Suda,T. and Durocher,D.
    Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1
    Nature (2010) 466, 941-946. PubMed  Europe PubMed DOI
    88. 2009
  88. Edelmann,M.J., Iphofer,A., Akutsu,M., Altun,M., di Gleria,K., Kramer,H.B., Fiebiger,E., Dhe-Paganon,S. and Kessler,B.M.
    Structural basis and specificity of human otubain 1-mediated deubiquitination
    Biochem J (2009) 418, 379-390. PubMed  Europe PubMed DOI
  89. Lin,J.T., Lineberry,N.B., Kattah,M.G., Su,L.L., Utz,P.J., Fathman,C.G. and Wu,L.
    Naive CD4 t cell proliferation is controlled by mammalian target of rapamycin regulation of GRAIL expression
    J Immunol (2009) 182, 5919-5928. PubMed  Europe PubMed DOI  PMC  EPMC
  90. Stanisic,V., Malovannaya,A., Qin,J., Lonard,D.M. and O'Malley,B.W.
    OTU Domain-containing ubiquitin aldehyde-binding protein 1 (OTUB1) deubiquitinates estrogen receptor (ER) alpha and affects ERalpha transcriptional activity
    J Biol Chem (2009) 284, 16135-16145. PubMed  Europe PubMed DOI  PMC  EPMC
  91. Wang,T., Yin,L., Cooper,E.M., Lai,M.Y., Dickey,S., Pickart,C.M., Fushman,D., Wilkinson,K.D., Cohen,R.E. and Wolberger,C.
    Evidence for bidentate substrate binding as the basis for the K48 linkage specificity of otubain 1
    J Mol Biol (2009) 386, 1011-1023. PubMed  Europe PubMed DOI  PMC  EPMC  P
    92. 2006
  92. Juris,S.J., Shah,K., Shokat,K., Dixon,J.E. and Vacratsis,P.O.
    Identification of otubain 1 as a novel substrate for the Yersinia protein kinase using chemical genetics and mass spectrometry
    FEBS Lett (2006) 580, 179-183. PubMed  Europe PubMed DOI
    93. 2004
  93. Soares,L., Seroogy,C., Skrenta,H., Anandasabapathy,N., Lovelace,P., Chung,C.D., Engleman,E. and Fathman,C.G.
    Two isoforms of otubain 1 regulate T cell anergy via GRAIL
    Nat Immunol (2004) 5, 45-54. PubMed  Europe PubMed DOI
    94. 2003
  94. Balakirev,M.Y., Tcherniuk,S.O., Jaquinod,M. and Chroboczek,J.
    Otubains: a new family of cysteine proteases in the ubiquitin pathway
    EMBO Rep (2003) 4, 517-522. PubMed  Europe PubMed DOI  PMC  EPMC  I
    95. 1989
  95. Steinhauer,W.R., Walsh,R.C. and Kalfayan,L.J.
    Sequence and structure of the Drosophila melanogaster ovarian tumor gene and generation of an antibody specific for the ovarian tumor protein
    Mol Cell Biol (1989) 9, 5726-5732. PubMed  Europe PubMed  PMC  EPMC

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2026 EBI
Terms of use