$VAR1 = undef;

Summary for peptidase C65.001: otubain-1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

 

Names
MEROPS Nameotubain-1
Other namesCG4968 g.p. (Drosophila melanogaster), OTUB1 g.p. (Homo sapiens)
Domain architecture
MEROPS Classification
Classification Clan CA >> Subclan (none) >> Family C65 >> Subfamily (none) >> C65.001
Holotypeotubain-1 (Homo sapiens), Uniprot accession Q96FW1 (peptidase unit: 1-271), MERNUM MER0029056
History Identifier created: MEROPS 6.3 (23 June 2003)
Activity
Catalytic typeCysteine
NC-IUBMBNot yet included in IUBMB recommendations.
Activity statushuman: active (Balakirev et al., 2003)
mouse: putative (Balakirev et al., 2003)
Other databases TREEFAMhttp://www.treefam.org/family/TF314145
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patternL/R/G/GScissile bondK/qei/lqs/edt (based on 14 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 0 0 14 14 0 0 0 0
Pro 0 0 0 0 0 0 0 0
Ala 0 0 0 0 0 0 0 0
Val 0 0 0 0 0 0 0 0
Leu 9 0 0 0 0 0 3 0
Ile 0 0 0 0 0 2 0 0
Met 0 0 0 0 0 0 0 0
Phe 1 0 0 0 0 0 0 0
Tyr 1 0 0 0 0 0 0 0
Trp 1 0 0 0 0 0 0 0
Ser 0 0 0 0 0 0 2 0
Thr 0 0 0 0 0 0 0 2
Cys 0 0 0 0 0 0 0 0
Asn 0 0 0 0 0 0 0 0
Gln 0 0 0 0 0 3 2 0
Asp 0 0 0 0 0 0 0 2
Glu 0 0 0 0 0 2 0 3
Lys 1 0 0 0 8 0 0 0
Arg 0 14 0 0 0 0 0 0
His 0 0 0 0 0 0 0 0
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
OTUB1 11q13.1 ENSG00000167770 55611 OTUB1 608337
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Otub1 19:A ENSMUSG00000024767 107260 MGI:2147616