Literature for peptidase M28.010: glutamate carboxypeptidase II

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

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    2016
  1. Novakova,Z., Wozniak,K., Jancarik,A., Rais,R., Wu,Y., Pavlicek,J., Ferraris,D., Havlinova,B., Ptacek,J., Vavra,J., Hin,N., Rojas,C., Majer,P., Slusher,B.S., Tsukamoto,T. and Barinka,C.
    Unprecedented binding mode of hydroxamate-based inhibitors of glutamate carboxypeptidase II: structural characterization and biological activity
    J Med Chem59, 4539-4550. PubMed  Europe PubMed DOI  S  I
  2. 2014
  3. Navratil,M., Ptacek,J., Sacha,P., Starkova,J., Lubkowski,J., Barinka,C. and Konvalinka,J.
    Structural and biochemical characterization of the folyl-poly-gamma-L-glutamate hydrolyzing activity of human glutamate carboxypeptidase II
    FEBS J281, 3228-3242. PubMed  Europe PubMed DOI  S
  4. Pavlicek,J., Ptacek,J., Cerny,J., Byun,Y., Skultetyova,L., Pomper,M.G., Lubkowski,J. and Barinka,C.
    Structural characterization of P1'-diversified urea-based inhibitors of glutamate carboxypeptidase II
    Bioorg Med Chem Lett24, 2340-2345. PubMed  Europe PubMed DOI  S  I
  5. 2012
  6. Pavlicek,J., Ptacek,J. and Barinka,C.
    Glutamate carboxypeptidase II: an overview of structural studies and their importance for structure-based drug design and deciphering the reaction mechanism of the enzyme
    Curr Med Chem19, 1300-1309. PubMed  Europe PubMed DOI  S
  7. 2011
  8. Plechanovova,A., Byun,Y., Alquicer,G., Skultetyova,L., Mlcochova,P., Nemcova,A., Kim,H.J., Navratil,M., Mease,R., Lubkowski,J., Pomper,M., Konvalinka,J., Rulisek,L. and Barinka,C.
    Novel substrate-based inhibitors of human glutamate carboxypeptidase II with enhanced lipophilicity
    J Med Chem54, 7535-7546. PubMed  Europe PubMed DOI  S  I
  9. 2010
  10. Wang,H., Byun,Y., Barinka,C., Pullambhatla,M., Bhang,H.E., Fox,J.J., Lubkowski,J., Mease,R.C. and Pomper,M.G.
    Bioisosterism of urea-based GCPII inhibitors: synthesis and structure-activity relationship studies
    Bioorg Med Chem Lett20, 392-397. PubMed  Europe PubMed DOI  S  I
  11. 2009
  12. Hlouchova,K., Barinka,C., Konvalinka,J. and Lubkowski,J.
    Structural insight into the evolutionary and pharmacologic homology of glutamate carboxypeptidases II and III
    FEBS J276, 4448-4462. PubMed  Europe PubMed DOI  S
  13. Klusak,V., Barinka,C., Plechanovova,A., Mlcochova,P., Konvalinka,J., Rulisek,L. and Lubkowski,J.
    Reaction mechanism of glutamate carboxypeptidase II revealed by mutagenesis, X-ray crystallography, and computational methods
    Biochemistry48, 4126-4138. PubMed  Europe PubMed DOI  S
  14. 2008
  15. Barinka,C., Byun,Y., Dusich,C.L., Banerjee,S.R., Chen,Y., Castanares,M., Kozikowski,A.P., Mease,R.C., Pomper,M.G. and Lubkowski,J.
    Interactions between human glutamate carboxypeptidase II and urea-based inhibitors: structural characterization
    J Med Chem51, 7737-7743. PubMed  Europe PubMed DOI  S  I
  16. 2007
  17. Barinka,C., Starkova,J., Konvalinka,J. and Lubkowski,J.
    A high-resolution structure of ligand-free human glutamate carboxypeptidase II
    Acta Crystallogr Sect F Struct Biol Cryst Commun63, 150-153. PubMed  Europe PubMed DOI  S
  18. Mesters,J.R., Henning,K. and Hilgenfeld,R.
    Human glutamate carboxypeptidase II inhibition: structures of GCPII in complex with two potent inhibitors, quisqualate and 2-PMPA
    Acta Crystallogr D Biol Crystallogr63, 508-513. PubMed  Europe PubMed DOI  S  I
  19. 2006
  20. [YEAR:9-2-2006]Mesters,J.R., Barinka,C., Li,W., Tsukamoto,T., Majer,P., Slusher,B.S., Konvalinka,J. and Hilgenfeld,R.
    Structure of glutamate carboxypeptidase II, a drug target in neuronal damage and prostate cancer
    EMBO J25, 1375-1384. PubMed  Europe PubMed DOI  S  T  I
  21. 2005
  22. [YEAR:26-4-2005]Davis,M.I., Bennett,M.J., Thomas,L.M. and Bjorkman,P.J.
    Crystal structure of prostate-specific membrane antigen, a tumor marker and peptidase
    Proc Natl Acad Sci U S A102, 5981-5986. PubMed  Europe PubMed DOI  S