Literature for peptidase C01.060: cathepsin B

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2026
1. Qing,Y., Xu,S., Yang,D., Liu,J. and Cao,H.
   Thalidezine triggers Cathepsin B-mediated cell death in T-cell lymphoma by disrupting lysosomal function
   Chem Biol Interact (2026) 427, 111932-111932. PubMed  Europe PubMed DOI  K
2025
2. Chen,S., Sun,K., Peng,C., Kuang,Y., Zhang,S., Li,R., Hu,H., Liu,S., Su,F., Qiu,Q., Liang,L., Jie,L., Xiao,Y. and Xu,H.
   METTL1-mediated internal m(7)G methylation of cathepsin B mRNA promotes synovial aggression in rheumatoid arthritis
   Ann Rheum Dis (2025) PubMed  Europe PubMed DOI  K
3. Guo,L., Li,Z., Hou,C. and Xu,J.
   Heat shock protein and Cathepsin B genes play important roles in cadmium stress response in whitefly Bemisia tabaci
   Sci Total Environ (2025) 1010, 181162-181162. PubMed  Europe PubMed DOI  K
4. Xie,Z., Yang,Q., Lan,F., Kong,W., Zhao,S., Sun,J., Yan,Y., Quan,Z., Bai,Z., Qing,H., Mao,J. and Ni,J.
   Cathepsin B deficiency disrupts cortical development via PEG3, leading to depression-like behavior
   Commun Biol (2025) 8, 1097-1097. PubMed  Europe PubMed DOI  PMC  EPMC  K
2024
5. Norton,E.S., Whaley,L.A., Jones,V.K., Brooks,M.M., Russo,M.N., Morderer,D., Jessen,E., Schiapparelli,P., Ramos-Fresnedo,A., Zarco,N., Carrano,A., Rossoll,W., Asmann,Y.W., Lam,T.T., Chaichana,K.L., Anastasiadis,P.Z., Quinones-Hinojosa,A. and Guerrero-Cazares,H.
   Cell-specific cross-talk proteomics reveals cathepsin B signaling as a driver of glioblastoma malignancy near the subventricular zone
   Sci Adv (2024) 10, eadn1607-eadn1607. PubMed  Europe PubMed DOI  PMC  EPMC  K
6. Siddiqui,A.A., Merquiol,E., Bruck-Haimson,R., Hirbawi,J., Boocholez,H., Cohen,I., Yan,Y., Dong,M.Q., Blum,G. and Cohen,E.
   Cathepsin B promotes Abeta proteotoxicity by modulating aging regulating mechanisms
   Nat Commun (2024) 15, 8564-8564. PubMed  Europe PubMed DOI  PMC  EPMC  K
7. Wang,D., Wang,T., Kim,D., Tan,S., Liu,S., Wan,J. and Deng,Q.
   MicroRNA-375 modulates neutrophil chemotaxis via targeting Cathepsin B in zebrafish
   Fish Shellfish Immunol (2024) 154, 109933-109933. PubMed  Europe PubMed DOI  K
2020
8. Izumida,M., Hayashi,H., Tanaka,A. and Kubo,Y.
   Cathepsin B Protease Facilitates Chikungunya Virus Envelope Protein-Mediated Infection via Endocytosis or Macropinocytosis
   Viruses (2020) 12 PubMed  Europe PubMed DOI  K
9. Liu,C., Cai,Z., Hu,T., Yao,Q. and Zhang,L.
   Cathepsin B aggravated doxorubicininduced myocardial injury via NFkappaB signalling
   Mol Med Rep (2020) 22, 4848-4856. PubMed  Europe PubMed DOI  PMC  EPMC  K
2019
10. Schwenck,J., Maurer,A., Fehrenbacher,B., Mehling,R., Knopf,P., Mucha,N., Haupt,D., Fuchs,K., Griessinger,C.M., Bukala,D., Holstein,J., Schaller,M., Menendez,I.G., Ghoreschi,K., Quintanilla-Martinez,L., Gutschow,M., Laufer,S., Reinheckel,T., Rocken,M., Kalbacher,H., Pichler,B.J. and Kneilling,M.
    Cysteine-type cathepsins promote the effector phase of acute cutaneous delayed-type hypersensitivity reactions
    Theranostics (2019) 9, 3903-3917. PubMed  Europe PubMed DOI  PMC  EPMC  K
2018
11. Gnanamony,M. and Gondi,C.S.
    Targeting the expression of cathepsin B using CRISPR/Cas9 system in mammalian cancer cells
    Methods Mol Biol (2018) 1731, 123-131. PubMed  Europe PubMed DOI  K
2016
12. Akkari,L., Gocheva,V., Quick,M.L., Kester,J.C., Spencer,A.K., Garfall,A.L., Bowman,R.L. and Joyce,J.A.
    Combined deletion of cathepsin protease family members reveals compensatory mechanisms in cancer
    Genes Dev (2016) 30, 220-232. PubMed  Europe PubMed DOI  PMC  EPMC  K
2015
13. Weber,E., Barbulescu,E., Medek,R., Reinheckel,T., Sameni,M., Anbalagan,A., Moin,K. and Sloane,B.F.
    Cathepsin B-deficient mice as source of monoclonal anti-cathepsin B antibodies
    Biol Chem (2015) 396, 277-281. PubMed  Europe PubMed DOI  K
2014
14. Tholen,S., Biniossek,M.L., Gansz,M., Ahrens,T.D., Schlimpert,M., Kizhakkedathu,J.N., Reinheckel,T. and Schilling,O.
    Double deficiency of cathepsins B and L results in massive secretome alterations and suggests a degradative cathepsin-MMP axis
    Cell Mol Life Sci (2014) 71, 899-916. PubMed  Europe PubMed DOI  K
2013
15. Bao,W., Fan,Q., Luo,X., Cheng,W.W., Wang,Y.D., Li,Z.N., Chen,X.L. and Wu,D.
    Silencing of cathepsin B suppresses the proliferation and invasion of endometrial cancer
    Oncol Rep (2013) 30, 723-730. PubMed  Europe PubMed DOI  K
16. Buhler,A., Berger,S., Bengsch,F., Martin,G., Han,H., Vierkotten,S., Pielen,A., Boehringer,D., Schlunck,G., Fauser,S., Agostini,H.T., Reinheckel,T. and Stahl,A.
    Cathepsin proteases promote angiogenic sprouting and laser-induced choroidal neovascularisation in mice
    Exp Eye Res (2013) 115, 73-78. PubMed  Europe PubMed DOI  K
17. Rao Malla,R., Gopinath,S., Alapati,K., Gorantla,B., Gondi,C.S. and Rao,J.S.
    Knockdown of cathepsin B and uPAR inhibits CD151 and alpha3beta1 integrin-mediated cell adhesion and invasion in glioma
    Mol Carcinog (2013) 52, 777-790. PubMed  Europe PubMed DOI  K
18. Tholen,S., Biniossek,M.L., Gansz,M., Gomez-Auli,A., Bengsch,F., Noel,A., Kizhakkedathu,J.N., Boerries,M., Busch,H., Reinheckel,T. and Schilling,O.
    Deletion of cysteine cathepsins B or L yields differential impacts on murine skin proteome and degradome
    Mol Cell Proteomics (2013) 12, 611-625. PubMed  Europe PubMed DOI  K
2012
19. Kindy,M.S., Yu,J., Zhu,H., El-Amouri,S.S., Hook,V. and Hook,G.R.
    Deletion of the cathepsin B gene improves memory deficits in a transgenic Alzheimer's disease mouse model expressing AbetaPP containing the wild-type beta-secretase site sequence
    J Alzheimers Dis (2012) 29, 827-840. PubMed  Europe PubMed DOI  K
20. Kong,L. and Zhou,G.H.
    Cathepsin B-RNAi-lentivirus inhibitis capillary-like tube formation in vitro
    Acta Anat Sin (2012) 43, 377-380. DOI  K
2010
21. Mercure,C., Lacombe,M.J., Khazaie,K. and Reudelhuber,T.L.
    Cathepsin B is not the processing enzyme for mouse prorenin
    Am J Physiol Regul Integr Comp Physiol (2010) 298, R1212-R1216. PubMed  Europe PubMed DOI  K
22. Sevenich,L., Schurigt,U., Sachse,K., Gajda,M., Werner,F., Muller,S., Vasiljeva,O., Schwinde,A., Klemm,N., Deussing,J., Peters,C. and Reinheckel,T.
    Synergistic antitumor effects of combined cathepsin B and cathepsin Z deficiencies on breast cancer progression and metastasis in mice
    Proc Natl Acad Sci U S A (2010) 107, 2497-2502. PubMed  Europe PubMed DOI  K
2008
23. Vasiljeva,O., Korovin,M., Gajda,M., Brodoefel,H., Bojic,L., Kruger,A., Schurigt,U., Sevenich,L., Turk,B., Peters,C. and Reinheckel,T.
    Reduced tumour cell proliferation and delayed development of high-grade mammary carcinomas in cathepsin B-deficient mice
    Oncogene (2008) 27, 4191-4199. PubMed  Europe PubMed DOI  K
2007
24. Stahl,S., Reinders,Y., Asan,E., Mothes,W., Conzelmann,E., Sickmann,A. and Felbor,U.
    Proteomic analysis of cathepsin B- and L-deficient mouse brain lysosomes
    Biochim Biophys Acta (2007) 1774, 1237-1246. PubMed  Europe PubMed DOI  K
2005
25. Koike,M., Shibata,M., Waguri,S., Yoshimura,K., Tanida,I., Kominami,E., Gotow,T., Peters,C., von Figura,K., Mizushima,N., Saftig,P. and Uchiyama,Y.
    Participation of autophagy in storage of lysosomes in neurons from mouse models of neuronal ceroid-lipofuscinoses (Batten disease)
    Am J Pathol (2005) 167, 1713-1728. PubMed  Europe PubMed DOI  PMC  EPMC  K
2002
26. [YEAR:11-6-2002]Felbor,U., Kessler,B., Mothes,W., Goebel,H.H., Ploegh,H.L., Bronson,R.T. and Olsen,B.R.
    Neuronal loss and brain atrophy in mice lacking cathepsins B and L
    Proc Natl Acad Sci U S A (11-6-2002) 99, 7883-7888. PubMed  Europe PubMed DOI  PMC  EPMC  K
2001
27. Reinheckel,T., Deussing,J., Roth,W. and Peters,C.
    Towards specific functions of lysosomal cysteine peptidases: phenotypes of mice deficient for cathepsin B or cathepsin L
    Biol Chem (2001) 382, 735-741. PubMed  Europe PubMed DOI  K
2000
28. Halangk,W., Lerch,M.M., Brandt-Nedelev,B., Roth,W., Ruthenbuerger,M., Reinheckel,T., Domschke,W., Lippert,H., Peters,C. and Deussing,J.
    Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis
    J Clin Invest (2000) 106, 773-781. PubMed  Europe PubMed DOI  PMC  EPMC  K
1999
29. [YEAR:1-12-1999]Krueger,S., Haeckel,C., Buehling,F. and Roessner,A.
    Inhibitory effects of antisense cathepsin B cDNA transfection on invasion and motility in a human osteosarcoma cell line
    Cancer Res (1-12-1999) 59, 6010-6014. PubMed  Europe PubMed  K
1998
30. [YEAR:14-4-1998]Deussing,J., Roth,W., Saftig,P., Peters,C., Ploegh,H.L. and Villadangos,J.A.
    Cathepsins B and D are dispensable for major histocompatibility complex class II-mediated antigen presentation
    Proc Natl Acad Sci U S A (14-4-1998) 95, 4516-4521. PubMed  Europe PubMed DOI  PMC  EPMC  K