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Literature for peptidase T01.011: proteasome subunit beta2c

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(References are filtered for relevance to Inhibitor. To remove the filter click here. See explanation.)

    2019
  1. Besse,A., Besse,L., Kraus,M., Mendez-Lopez,M., Bader,J., Xin,B.T., de Bruin,G., Maurits,E., Overkleeft,H.S. and Driessen,C.
    Proteasome Inhibition in Multiple Myeloma: Head-to-Head Comparison of Currently Available Proteasome Inhibitors
    Cell Chem Biol26, 340-351. PubMed  Europe PubMed DOI  I
  2. Steverding,D., Florea,B.I. and Overkleeft,H.S.
    Trypanosoma brucei: beta2-selective proteasome inhibitors do not block the proteasomal trypsin-like activity but are trypanocidal
    Mol Biochem Parasitol227, 1-4. PubMed  Europe PubMed DOI  I
  3. Xin,B.T., Huber,E.M., de Bruin,G., Heinemeyer,W., Maurits,E., Espinal,C., Du,Y., Janssens,M., Weyburne,E.S., Kisselev,A.F., Florea,B.I., Driessen,C., van der Marel,G.A., Groll,M. and Overkleeft,H.S.
    Structure-based design of inhibitors selective for human proteasome beta2c or beta2i subunits
    J Med Chem62, 1626-1642. PubMed  Europe PubMed DOI  I
    4. 2018
  4. Artschwager,R., Ward,D.J., Gannon,S., Brouwer,A.J., van de Langemheen,H., Kowalski,H. and Liskamp,R.M.J.
    Potent and highly selective inhibitors of the proteasome trypsin-like site by incorporation of basic side chain containing amino acid derived sulfonyl fluorides
    J Med Chem61, 5395-5411. PubMed  Europe PubMed DOI  I
  5. Pierce,M.R., Bakas,N.A., Pirrung,M.C. and Bachmann,A.S.
    Thiasyrbactins induce cell death via proteasome inhibition in multiple myeloma cells
    Anticancer Res38, 5607-5613. PubMed  Europe PubMed DOI  I
    6. 2017
  6. Hewings,D.S., Flygare,J.A., Wertz,I.E. and Bogyo,M.
    Activity-based probes for the multicatalytic proteasome
    FEBS J284, 1540-1554. PubMed  Europe PubMed DOI  V  L  I
  7. Rolfe,M.
    The holy grail: solid tumor efficacy by proteasome inhibition
    Cell Chem Biol24, 125-126. PubMed  Europe PubMed DOI  T  I
  8. Weyburne,E.S., Wilkins,O.M., Sha,Z., Williams,D.A., Pletnev,A.A., de Bruin,G., Overkleeft,H.S., Goldberg,A.L., Cole,M.D. and Kisselev,A.F.
    Inhibition of the proteasome beta2 site sensitizes triple-negative breast cancer cells to beta5 inhibitors and suppresses Nrf1 activation
    Cell Chem Biol24, 218-230. PubMed  Europe PubMed DOI  T  I
    9. 2016
  9. de Bruin,G., Xin,B.T., Kraus,M., van der Stelt,M., van der Marel,G.A., Kisselev,A.F., Driessen,C., Florea,B.I. and Overkleeft,H.S.
    A set of activity-based probes to visualize human (immuno)proteasome activities
    Angew Chem Int Ed Engl55, 4199-4203. PubMed  Europe PubMed DOI  A  I
  10. Zhou,T., Cai,Y., Liang,L., Yang,L., Xu,F., Niu,Y., Wang,C., Zhang,J.L. and Xu,P.
    Discovery of a potent and highly specific beta2 proteasome inhibitor from a library of copper complexes
    Bioorg Med Chem Lett26, 5780-5784. PubMed  Europe PubMed DOI  I
    11. 2015
  11. Huber,E.M., Heinemeyer,W. and Groll,M.
    Bortezomib-resistant mutant proteasomes: structural and biochemical evaluation with carfilzomib and ONX 0914
    Structure23, 407-417. PubMed  Europe PubMed DOI  S  I
  12. Huber,E.M., de Bruin,G., Heinemeyer,W., Paniagua Soriano,G., Overkleeft,H.S. and Groll,M.
    Systematic analyses of substrate preferences of 20S proteasomes using peptidic epoxyketone inhibitors
    J Am Chem Soc137, 7835-7842. PubMed  Europe PubMed DOI  P  S  I
  13. Koroleva,O.N., Pham,T.H., Bouvier,D., Dufau,L., Qin,L., Reboud-Ravaux,M., Ivanov,A.A., Zhuze,A.L., Gromova,E.S. and Bouvier-Durand,M.
    Bisbenzimidazole derivatives as potent inhibitors of the trypsin-like sites of the immunoproteasome core particle
    Biochimie108C, 94-100. PubMed  Europe PubMed DOI  I
  14. Kraus,J., Kraus,M., Liu,N., Besse,L., Bader,J., Geurink,P.P., de Bruin,G., Kisselev,A.F., Overkleeft,H. and Driessen,C.
    The novel beta2-selective proteasome inhibitor LU-102 decreases phosphorylation of I kappa B and induces highly synergistic cytotoxicity in combination with ibrutinib in multiple myeloma cells
    Cancer Chemother Pharmacol76, 383-396. PubMed  Europe PubMed DOI  I
  15. Kraus,M., Bader,J., Geurink,P.P., Weyburne,E.S., Mirabella,A.C., Silzle,T., Shabaneh,T.B., van der Linden,W.A., de Bruin,G., Haile,S.R., van Rooden,E., Appenzeller,C., Li,N., Kisselev,A.F., Overkleeft,H. and Driessen,C.
    The novel beta2-selective proteasome inhibitor LU-102 synergizes with bortezomib and carfilzomib to overcome proteasome inhibitor resistance of myeloma cells
    Haematologica100, 1350-1360. PubMed  Europe PubMed DOI  I
  16. Zhu,Z., Zhang,L. and Shi,G.
    Proteasome as a molecular target of microcystin-LR
    Toxins (Basel)7, 2221-2231. PubMed  Europe PubMed DOI  I
    17. 2014
  17. Loizidou,E.Z. and Zeinalipour-Yazdi,C.D.
    Computational inhibition studies of the human proteasome by argyrin-based analogues with subunit specificity
    Chem Biol Drug Des84, 99-107. PubMed  Europe PubMed DOI  I
    18. 2013
  18. Geurink,P.P., van der Linden,W.A., Mirabella,A.C., Gallastegui,N., de Bruin,G., Blom,A.E., Voges,M.J., Mock,E.D., Florea,B.I., van der Marel,G.A., Driessen,C., van der Stelt,M., Groll,M., Overkleeft,H.S. and Kisselev,A.F.
    Incorporation of non-natural amino acids improves cell permeability and potency of specific inhibitors of proteasome trypsin-like sites
    J Med Chem56, 1262-1275. PubMed  Europe PubMed DOI  I
  19. Gotze,S., Bose,A., Abele,D., Sokolova,I.M. and Saborowski,R.
    Pitfalls in invertebrate proteasome assays
    J Exp Biol216, 1351-1354. PubMed  Europe PubMed DOI  A  I
    20. 2012
  20. Pereira,A.R., Kale,A.J., Fenley,A.T., Byrum,T., Debonsi,H.M., Gilson,M.K., Valeriote,F.A., Moore,B.S. and Gerwick,W.H.
    The carmaphycins: new proteasome inhibitors exhibiting an alpha,beta-epoxyketone warhead from a marine cyanobacterium
    Chembiochem13, 810-817. PubMed  Europe PubMed DOI  I
    21. 2011
  21. Mirabella,A.C., Pletnev,A.A., Downey,S.L., Florea,B.I., Shabaneh,T.B., Britton,M., Verdoes,M., Filippov,D.V., Overkleeft,H.S. and Kisselev,A.F.
    Specific cell-permeable inhibitor of proteasome trypsin-like sites selectively sensitizes myeloma cells to bortezomib and carfilzomib
    Chem Biol18, 608-618. PubMed  Europe PubMed DOI  I
    22. 2010
  22. Screen,M., Britton,M., Downey,S.L., Verdoes,M., Voges,M.J., Blom,A.E., Geurink,P.P., Risseeuw,M.D., Florea,B.I., van der Linden,W.A., Pletnev,A.A., Overkleeft,H.S. and Kisselev,A.F.
    Nature of pharmacophore influences active site specificity of proteasome inhibitors
    J Biol Chem285, 40125-40134. PubMed  Europe PubMed DOI  I
  23. Wu,Y.X. and Fang,X.
    Apigenin, chrysin, and luteolin selectively inhibit chymotrypsin-like and trypsin-like proteasome catalytic activities in tumor cells
    Planta Med76, 128-132. PubMed  Europe PubMed DOI  I
    24. 2009
  24. Britton,M., Lucas,M.M., Downey,S.L., Screen,M., Pletnev,A.A., Verdoes,M., Tokhunts,R.A., Amir,O., Goddard,A.L., Pelphrey,P.M., Wright,D.L., Overkleeft,H.S. and Kisselev,A.F.
    Selective inhibitor of proteasome's caspase-like sites sensitizes cells to specific inhibition of chymotrypsin-like sites
    Chem Biol16, 1278-1289. PubMed  Europe PubMed DOI  I
    25. 2008
  25. Baldisserotto,A., Marastoni,M., Lazzari,I., Trapella,C., Gavioli,R. and Tomatis,R.
    C-terminal constrained phenylalanine as a pharmacophoric unit in peptide-based proteasome inhibitors
    Eur J Med Chem43, 1403-1411. PubMed  Europe PubMed DOI  I
    26. 2007
  26. Baldisserotto,A., Marastoni,M., Trapella,C., Gavioli,R., Ferretti,V., Pretto,L. and Tomatis,R.
    Glutamine vinyl ester proteasome inhibitors selective for trypsin-like (beta2) subunit
    Eur J Med Chem42, 586-592. PubMed  Europe PubMed DOI  I
  27. Miller,C.P., Ban,K., Dujka,M.E., McConkey,D.J., Munsell,M., Palladino,M. and Chandra,J.
    NPI-0052, a novel proteasome inhibitor, induces caspase-8 and ROS-dependent apoptosis alone and in combination with HDAC inhibitors in leukemia cells
    Blood110, 267-277. PubMed  Europe PubMed DOI  I
    28. 2006
  28. [YEAR:15-6-2006]Crawford,L.J., Walker,B., Ovaa,H., Chauhan,D., Anderson,K.C., Morris,T.C. and Irvine,A.E.
    Comparative selectivity and specificity of the proteasome inhibitors BzLLLCOCHO, PS-341, and MG-132
    Cancer Res66, 6379-6386. PubMed  Europe PubMed DOI  I
  29. Groll,M., Gotz,M., Kaiser,M., Weyher,E. and Moroder,L.
    TMC-95-Based inhibitor design provides evidence for the catalytic versatility of the proteasome
    Chem Biol13, 607-614. PubMed  Europe PubMed DOI  I
  30. [YEAR:4-4-2006]Marastoni,M., Baldisserotto,A., Trapella,C., Gavioli,R. and Tomatis,R.
    P3 and P4 position analysis of vinyl ester pseudopeptide proteasome inhibitors
    Bioorg Med Chem Lett16, 3125-3130. PubMed  Europe PubMed DOI  I
    31. 2005
  31. [YEAR:9-6-2005]Braun,H.A., Umbreen,S., Groll,M., Kuckelkorn,U., Mlynarczuk,I., Wigand,M.E., Drung,I., Kloetzel,P.M. and Schmidt,B.
    Tripeptide mimetics inhibit the 20 S proteasome by covalent bonding to the active threonines
    J Biol Chem280, 28394-28401. PubMed  Europe PubMed DOI  I
  32. Gaczynska,M. and Osmulski,P.A.
    Small-molecule inhibitors of proteasome activity
    Methods Mol Biol301, 3-22. PubMed  Europe PubMed DOI  I
  33. [YEAR:28-7-2005]Marastoni,M., Baldisserotto,A., Cellini,S., Gavioli,R. and Tomatis,R.
    Peptidyl vinyl ester derivatives: new class of selective inhibitors of proteasome trypsin-like activity
    J Med Chem48, 5038-5042. PubMed  Europe PubMed DOI  I
  34. Steverding,D., Spackman,R.W., Royle,H.J. and Glenn,R.J.
    Trypanocidal activities of trileucine methyl vinyl sulfone proteasome inhibitors
    Parasitol Res95, 73-76. PubMed  Europe PubMed DOI  I
    35. 2004
  35. [YEAR:29-11-2004]Groll,M. and Huber,R.
    Inhibitors of the eukaryotic 20S proteasome core particle: a structural approach
    Biochim Biophys Acta1695, 33-44. PubMed  Europe PubMed DOI  V  I
    36. 2002
  36. Groll,M., Nazif,T., Huber,R. and Bogyo,M.
    Probing structural determinants distal to the site of hydrolysis that control substrate specificity of the 20S proteasome
    Chem Biol9, 655-662. PubMed  Europe PubMed DOI  S  I
    37. 2001
  37. Kessler,B.M., Tortorella,D., Altun,M., Kisselev,A.F., Fiebiger,E., Hekking,B.G., Ploegh,H.L. and Overkleeft,H.S.
    Extended peptide-based inhibitors efficiently target the proteasome and reveal overlapping specificities of the catalytic beta-subunits
    Chem Biol8, 913-929. PubMed  Europe PubMed DOI  I
  38. [YEAR:13-3-2001]Nazif,T. and Bogyo,M.
    Global analysis of proteasomal substrate specificity using positional-scanning libraries of covalent inhibitors
    Proc Natl Acad Sci U S A98, 2967-2972. PubMed  Europe PubMed DOI  I
    39. 2000
  39. [YEAR:19-5-2000]Kisselev,A.F., Songyang,Z. and Goldberg,A.L.
    Why does threonine, and not serine, function as the active site nucleophile in proteasomes?
    J Biol Chem275, 14831-14837. PubMed  Europe PubMed DOI  I
  40. Koguchi,Y., Kohno,J., Nishio,M., Takahashi,K., Okuda,T., Ohnuki,T. and Komatsubara,S.
    TMC-95A, B, C, and D, novel proteasome inhibitors produced by Apiospora montagnei Sacc. TC 1093. Taxonomy, production, isolation, and biological activities
    J Antibiot (Tokyo)53, 105-109. PubMed  Europe PubMed  I
  41. [YEAR:21-7-2000]Schmidtke,G., Emch,S., Groettrup,M. and Holzhutter,H.G.
    Evidence for the existence of a non-catalytic modifier site of peptide hydrolysis by the 20 S proteasome
    J Biol Chem275, 22056-22063. PubMed  Europe PubMed DOI  I
    42. 1999
  42. Elofsson,M., Splittgerber,U., Myung,J., Mohan,R. and Crews,C.M.
    Towards subunit-specific proteasome inhibitors: synthesis and evaluation of peptide alpha',beta'-epoxyketones
    Chem Biol6, 811-822. PubMed  Europe PubMed DOI  I
    43. 1994
  43. Khan,M.T., Wang,K., Auland,M.E., Kable,E.P. and Roufogalis,B.D.
    Membrane-bound high molecular mass proteinases from human erythrocytes
    Biochim Biophys Acta1209, 215-221. PubMed  Europe PubMed  I
    44. 1993
  44. Savory,P.J. and Rivett,A.J.
    Leupeptin-binding site(s) in the mammalian multicatalytic proteinase complex
    Biochem J289, 45-48. PubMed  Europe PubMed  I
    45. 1989
  45. Orlowski,M. and Michaud,C.
    Pituitary multicatalytic proteinase complex. Specificity of components and aspects of proteolytic activity
    Biochemistry28, 9270-9278. PubMed  Europe PubMed DOI  I

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