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Literature for peptidase S09.018: dipeptidyl-peptidase 8

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(References are filtered for relevance to Inhibitor. To remove the filter click here. See explanation.)

    2022
  1. Benramdane,S., De Loose,J., Beyens,O., Van Rymenant,Y., Vliegen,G., Augustyns,K., De Winter,H., De Meester,I. and Van der Veken,P.
    Vildagliptin-Derived Dipeptidyl Peptidase 9 (DPP9) Inhibitors: Identification of a DPP8/9-Specific Lead
    ChemMedChem17, e202200097-e202200097. PubMed  Europe PubMed DOI  I
    2. 2019
  2. de Vasconcelos,N.M., Vliegen,G., Goncalves,A., De Hert,E., Martin-Perez,R., Van Opdenbosch,N., Jallapally,A., Geiss-Friedlander,R., Lambeir,A.M., Augustyns,K., Van der Veken,P., De Meester,I. and Lamkanfi,M.
    DPP8/DPP9 inhibition elicits canonical Nlrp1b inflammasome hallmarks in murine macrophages
    Life Sci Alliance2, PubMed  Europe PubMed DOI  I
    3. 2017
  3. Okondo,M.C., Johnson,D.C., Sridharan,R., Go,E.B., Chui,A.J., Wang,M.S., Poplawski,S.E., Wu,W., Liu,Y., Lai,J.H., Sanford,D.G., Arciprete,M.O., Golub,T.R., Bachovchin,W.W. and Bachovchin,D.A.
    DPP8 and DPP9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosis
    Nat Chem Biol13, 46-53. PubMed  Europe PubMed DOI  I
    4. 2016
  4. Heirbaut,L., VanGoethem,S., Jansen,K., DeWinter,H., Lamoen,N., Joossens,J., Cheng,J., Chen,X., Lambeir,A.-M., DeMeester,I., Augustyns,K. and VanDer Veken,P.
    Probing for improved selectivity with dipeptide-derived inhibitors of dipeptidyl peptidases 8 and 9: the impact of P1-variation
    MedChemComm7, 433-438. DOI  I
    5. 2015
  5. Huan,Y., Jiang,Q., Liu,J.-L. and Shen,Z.-F.
    Establishment of a dipeptidyl peptidases (DPP) 8/9 expressing cell model for evaluating the selectivity of DPP4 inhibitors
    J Pharmacol Toxicol Methods71, 8-12. PubMed  Europe PubMed DOI  I
    6. 2014
  6. Kwan,J.C., Liu,Y., Ratnayake,R., Hatano,R., Kuribara,A., Morimoto,C., Ohnuma,K., Paul,V.J., Ye,T. and Luesch,H.
    Grassypeptolides as natural inhibitors of dipeptidyl peptidase 8 and T-cell activation
    Chembiochem15, 799-804. PubMed  Europe PubMed DOI  I
    7. 2013
  7. Pilla,E., Kilisch,M., Lenz,C., Urlaub,H. and Geiss-Friedlander,R.
    The SUMO1-E67 interacting loop peptide is an allosteric inhibitor of the dipeptidyl peptidases 8 and 9
    J Biol Chem288, 32787-32796. PubMed  Europe PubMed DOI  I
    8. 2012
  8. Wu,W., Liu,Y., Milo,L.J., Jr., Shu,Y., Zhao,P., Li,Y., Woznica,I., Yu,G., Sanford,D.G., Zhou,Y., Poplawski,S.E., Connolly,B.A., Sudmeier,J.L., Bachovchin,W.W. and Lai,J.H.
    4-Substituted boro-proline dipeptides: synthesis, characterization, and dipeptidyl peptidase IV, 8, and 9 activities
    Bioorg Med Chem Lett22, 5536-5540. PubMed  Europe PubMed DOI  I
    9. 2011
  9. Chen,S.J. and Jiaang,W.T.
    Current advances and therapeutic potential of agents targeting dipeptidyl peptidases-IV, -II, 8/9 and fibroblast activation protein
    Curr Top Med Chem11, 1447-1463. PubMed  Europe PubMed DOI  I
  10. Van Goethem,S., Matheeussen,V., Joossens,J., Lambeir,A.M., Chen,X., De Meester,I., Haemers,A., Augustyns,K. and Van der Veken,P.
    Structure-activity relationship studies on isoindoline inhibitors of dipeptidyl peptidases 8 and 9 (DPP8, DPP9): is DPP8-selectivity an attainable goal?
    J Med Chem54, 5737-5746. PubMed  Europe PubMed DOI  I
    11. 2010
  11. Kirby,M., Yu,D.M., O'Connor,S. and Gorrell,M.D.
    Inhibitor selectivity in the clinical application of dipeptidyl peptidase-4 inhibition
    Clin Sci (Lond)118, 31-41. PubMed  Europe PubMed DOI  I
    12. 2009
  12. Reinhold,D., Goihl,A., Wrenger,S., Reinhold,A., Kuhlmann,U.C., Faust,J., Neubert,K., Thielitz,A., Brocke,S., Tager,M., Ansorge,S. and Bank,U.
    Role of dipeptidyl peptidase IV (DP IV)-like enzymes in T lymphocyte activation: investigations in DP IV/CD26-knockout mice
    Clin Chem Lab Med47, 268-274. PubMed  Europe PubMed DOI  I
  13. Wu,J.J., Tang,H.K., Yeh,T.K., Chen,C.M., Shy,H.S., Chu,Y.R., Chien,C.H., Tsai,T.Y., Huang,Y.C., Huang,Y.L., Huang,C.H., Tseng,H.Y., Jiaang,W.T., Chao,Y.S. and Chen,X.
    Biochemistry, pharmacokinetics, and toxicology of a potent and selective DPP8/9 inhibitor
    Biochem Pharmacol78, 203-210. PubMed  Europe PubMed DOI  I
  14. Yazbeck,R., Howarth,G.S. and Abbott,C.A.
    Dipeptidyl peptidase inhibitors, an emerging drug class for inflammatory disease?
    Trends Pharmacol Sci30, 600-607. PubMed  Europe PubMed DOI  I
    15. 2008
  15. Van der Veken,P., De Meester,I., Dubois,V., Soroka,A., Van Goethem,S., Maes,M.B., Brandt,I., Lambeir,A.M., Chen,X., Haemers,A., Scharpe,S. and Augustyns,K.
    Inhibitors of dipeptidyl peptidase 8 and dipeptidyl peptidase 9. Part 1: Identification of dipeptide derived leads
    Bioorg Med Chem Lett18, 4154-4158. PubMed  Europe PubMed DOI  I
  16. Van Goethem,S., Van der Veken,P., Dubois,V., Soroka,A., Lambeir,A.M., Chen,X., Haemers,A., Scharpe,S., De Meester,I. and Augustyns,K.
    Inhibitors of dipeptidyl peptidase 8 and dipeptidyl peptidase 9. Part 2: Isoindoline containing inhibitors
    Bioorg Med Chem Lett18, 4159-4162. PubMed  Europe PubMed DOI  I
    17. 2007
  17. Thornberry,N.A. and Weber,A.E.
    Discovery of JANUVIA (Sitagliptin), a selective dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes
    Curr Top Med Chem7, 557-568. PubMed  Europe PubMed DOI  I
  18. Van der Veken,P., Soroka,A., Brandt,I., Chen,Y.S., Maes,M.B., Lambeir,A.M., Chen,X., Haemers,A., Scharpe,S., Augustyns,K. and De Meester,I.
    Irreversible inhibition of dipeptidyl peptidase 8 by dipeptide-derived diaryl phosphonates
    J Med Chem50, 5568-5570. PubMed  Europe PubMed DOI  I
    19. 2005
  19. Jiaang,W.T., Chen,Y.S., Hsu,T., Wu,S.H., Chien,C.H., Chang,C.N., Chang,S.P., Lee,S.J. and Chen,X.
    Novel isoindoline compounds for potent and selective inhibition of prolyl dipeptidase DPP8
    Bioorg Med Chem Lett15, 687-691. PubMed  Europe PubMed DOI  I
  20. Lankas,G.R., Leiting,B., Roy,R.S., Eiermann,G.J., Beconi,M.G., Biftu,T., Chan,C.C., Edmondson,S., Feeney,W.P., He,H., Ippolito,D.E., Kim,D., Lyons,K.A., Ok,H.O., Patel,R.A., Petrov,A.N., Pryor,K.A., Qian,X., Reigle,L., Woods,A., Wu,J.K., Zaller,D., Zhang,X., Zhu,L., Weber,A.E. and Thornberry,N.A.
    Dipeptidyl peptidase IV inhibition for the treatment of type 2 diabetes: potential importance of selectivity over dipeptidyl peptidases 8 and 9
    Diabetes54, 2988-2994. PubMed  Europe PubMed DOI  I
  21. [YEAR:1-7-2005]Lu,I.L., Lee,S.J., Tsu,H., Wu,S.Y., Kao,K.H., Chien,C.H., Chang,Y.Y., Chen,Y.S., Cheng,J.H., Chang,C.N., Chen,T.W., Chang,S.P., Chen,X. and Jiaang,W.T.
    Glutamic acid analogues as potent dipeptidyl peptidase IV and 8 inhibitors
    Bioorg Med Chem Lett15, 3271-3275. PubMed  Europe PubMed DOI  I

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