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Literature for peptidase S01.131: elastase-2

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(References are filtered for relevance to Inhibitor. To remove the filter click here. See explanation.)

    2024
  1. Hwang,T.L., Lin,J.Y., Kuo,L.M., Kumar Dhandabani,G. and Hsieh,P.W.
    Design and synthesis of sirtinol analogs as human neutrophil elastase inhibitors
    Bioorg Med Chem Lett97, 129544-129544. PubMed  Europe PubMed DOI  I
  2. Jia,W., Mao,Y., Luo,Q., Wu,J. and Guan,Q.
    Targeting neutrophil elastase is a promising direction for future cancer treatment
    Discov Oncol15, 167-167. PubMed  Europe PubMed DOI  V  I
    3. 2023
  3. Cambier,S., Beretta,F., Portner,N., Metzemaekers,M., de Carvalho,A.C., Martens,E., Kaes,J., Aelbrecht,C., Jacobs,C., Van Mol,P., Wauters,E., Meersseman,P., Hermans,G., Marques,R.E., Vanaudenaerde,B., Vos,R., Wauters,J., Gouwy,M. and Proost,P.
    Proteolytic inactivation of CXCL12 in the lungs and circulation of COVID-19 patients
    Cell Mol Life Sci80, 234-234. PubMed  Europe PubMed DOI  I
  4. Lee,I.S., Lee,Y.R., Sim,J.H., Kim,K.M. and Kim,Y.S.
    The Effects of 1-O-Acetylbritannilactone Isolated from Inula britannica Flowers on Human Neutrophil Elastase and Inflammation of RAW 264.7 Cells and Zebrafish Larvae
    Molecules28, PubMed  Europe PubMed DOI  I
  5. Wang,K., Liao,Y., Li,X., Wang,R., Zeng,Z., Cheng,M., Gao,L., Xu,D., Wen,F., Wang,T. and Chen,J.
    Inhibition of neutrophil elastase prevents cigarette smoke exposure-induced formation of neutrophil extracellular traps and improves lung function in a mouse model of chronic obstructive pulmonary disease
    Int Immunopharmacol114, 109537-109537. PubMed  Europe PubMed DOI  I
  6. Zeng,W., Song,Y., Wang,R., He,R. and Wang,T.
    Neutrophil elastase: From mechanisms to therapeutic potential
    J Pharm Anal13, 355-366. PubMed  Europe PubMed DOI  V  I
    7. 2021
  7. Chen,K.J., Chen,Y.L., Ueng,S.H., Hwang,T.L., Kuo,L.M. and Hsieh,P.W.
    Neutrophil elastase inhibitor (MPH-966) improves intestinal mucosal damage and gut microbiota in a mouse model of 5-fluorouracil-induced intestinal mucositis
    Biomed Pharmacother134, 111152-111152. PubMed  Europe PubMed DOI  I
    8. 2020
  8. Barth,P., Bruijnzeel,P., Wach,A., Sellier Kessler,O., Hooftman,L., Zimmermann,J., Naue,N., Huber,B., Heimbeck,I., Kappeler,D., Timmer,W. and Chevalier,E.
    Single dose escalation studies with inhaled POL6014, a potent novel selective reversible inhibitor of human neutrophil elastase, in healthy volunteers and subjects with cystic fibrosis
    J Cyst Fibros19, 299-304. PubMed  Europe PubMed DOI  I
  9. Chalmers,J.D., Haworth,C.S., Metersky,M.L., Loebinger,M.R., Blasi,F., Sibila,O., O'Donnell,A.E., Sullivan,E.J., Mange,K.C., Fernandez,C., Zou,J. and Daley,C.L.
    Phase 2 Trial of the DPP-1 Inhibitor Brensocatib in Bronchiectasis
    N Engl J Med PubMed  Europe PubMed DOI  I
  10. Giovannoni,M.P., Crocetti,L., Cantini,N., Guerrini,G., Vergelli,C., Iacovone,A., Teodori,E., Schepetkin,I.A., Quinn,M.T., Ciattini,S., Rossi,P. and Paoli,P.
    New 3-unsubstituted isoxazolones as potent human neutrophil elastase inhibitors: synthesis and molecular dynamic simulation
    Drug Dev Res81, 338-349. PubMed  Europe PubMed DOI  I
  11. Luo,D. and Luesch,H.
    Ahp-Cyclodepsipeptide inhibitors of elastase: lyngbyastatin 7 stability, scalable synthesis, and focused library analysis
    ACS Med Chem Lett11, 419-425. PubMed  Europe PubMed DOI  I
  12. Okeke,E.B., Louttit,C., Fry,C., Najafabadi,A.H., Han,K., Nemzek,J. and Moon,J.J.
    Inhibition of neutrophil elastase prevents neutrophil extracellular trap formation and rescues mice from endotoxic shock
    Biomaterials238, 119836-119836. PubMed  Europe PubMed DOI  I
  13. Sugisaki,R., Miyamoto,Y., Yoshimura,K., Sasa,K., Kaneko,K., Tanaka,M., Itose,M., Inoue,S., Baba,K., Shirota,T., Chikazu,D. and Kamijo,R.
    Possible involvement of elastase in enhanced osteoclast differentiation by neutrophils through degradation of osteoprotegerin
    Bone132, 115216-115216. PubMed  Europe PubMed DOI  I
  14. Vidhya,R. and Anuradha,C.V.
    Anti-inflammatory effects of troxerutin are mediated through elastase inhibition
    Immunopharmacol Immunotoxicol1-13. PubMed  Europe PubMed DOI  I
    15. 2019
  15. Anderson,B.M., Poole,D.P., Aurelio,L., Ng,G.Z., Fleischmann,M., Kasperkiewicz,P., Morissette,C., Drag,M., van Driel,I.R., Schmidt,B.L., Vanner,S.J., Bunnett,N.W. and Edgington-Mitchell,L.E.
    Application of a chemical probe to detect neutrophil elastase activation during inflammatory bowel disease
    Sci Rep9, 13295-13295. PubMed  Europe PubMed DOI  A  I
  16. Crocetti,L., Quinn,M.T., Schepetkin,I.A. and Giovannoni,M.P.
    A patenting perspective on human neutrophil elastase (HNE) inhibitors (2014-2018) and their therapeutic applications
    Expert Opin Ther Pat29, 555-578. PubMed  Europe PubMed DOI  I
  17. Giovannoni,M.P., Cantini,N., Crocetti,L., Guerrini,G., Iacovone,A., Schepetkin,I.A., Vergelli,C., Khlebnikov,A.I. and Quinn,M.T.
    Further modifications of 1H-pyrrolo[2,3-b]pyridine derivatives as inhibitors of human neutrophil elastase
    Drug Dev Res80, 617-628. PubMed  Europe PubMed DOI  I
  18. Krasavin,M.Y., Gureev,M.A., Garabadzhiu,A.V., Pashkin,A.Y., Zhukov,A.S., Khairutdinov,V.R., Samtsov,A.V. and Shvets,V.I.
    Inhibition of neutrophil elastase and cathepsin G as a new approach to the treatment of psoriasis: from fundamental biology to development of new target-specific drugs
    Dokl Biochem Biophys487, 272-276. PubMed  Europe PubMed DOI  I
  19. Li,Z.P., Kim,J.Y., Ban,Y.J. and Park,K.H.
    Human neutrophil elastase (HNE) inhibitory polyprenylated acylphloroglucinols from the flowers of Hypericum ascyron
    Bioorg Chem90, 103075-103075. PubMed  Europe PubMed DOI  I
  20. Samy,M.N., Le Goff,G., Lopes,P., Georgousaki,K., Gumeni,S., Almeida,C., Gonzalez,I., Genilloud,O., Trougakos,I., Fokialakis,N. and Ouazzani,J.
    Osmanicin, a polyketide alkaloid isolated from Streptomyces osmaniensis CA-244599 inhibits elastase in human fibroblasts
    Molecules24, PubMed  Europe PubMed DOI  I
  21. Yao,W., Han,X., Guan,Y., Guan,J., Wu,S., Chen,C., Li,H. and Hei,Z.
    Neutrophil elastase inhibitors suppress oxidative stress in lung during liver transplantation
    Oxid Med Cell Longev2019, 7323986-7323986. PubMed  Europe PubMed DOI  I
  22. Zheng,Q., Woehl,J.L., Kitamura,S., Santos-Martins,D., Smedley,C.J., Li,G., Forli,S., Moses,J.E., Wolan,D.W. and Sharpless,K.B.
    SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase
    Proc Natl Acad Sci U S A116, 18808-18814. PubMed  Europe PubMed DOI  I
    23. 2018
  23. Antonio,J.P.M., Goncalves,L.M., Guedes,R.C., Moreira,R. and Gois,P.M.P.
    Diazaborines as new inhibitors of human neutrophil elastase
    ACS Omega3, 7418-7423. PubMed  Europe PubMed DOI  I
  24. Crocetti,L., Giovannoni,M.P., Schepetkin,I.A., Quinn,M.T., Khlebnikov,A.I., Cantini,N., Guerrini,G., Iacovone,A., Teodori,E. and Vergelli,C.
    1H-pyrrolo[2,3-b]pyridine: a new scaffold for human neutrophil elastase (HNE) inhibitors
    Bioorg Med Chem26, 5583-5595. PubMed  Europe PubMed DOI  I
  25. Giovannoni,M.P., Schepetkin,I.A., Quinn,M.T., Cantini,N., Crocetti,L., Guerrini,G., Iacovone,A., Paoli,P., Rossi,P., Bartolucci,G., Menicatti,M. and Vergelli,C.
    Synthesis, biological evaluation, and molecular modelling studies of potent human neutrophil elastase (HNE) inhibitors
    J Enzyme Inhib Med Chem33, 1108-1124. PubMed  Europe PubMed DOI  I
  26. Hochscherf,J., Pietsch,M., Tieu,W., Kuan,K., Abell,A.D., Gutschow,M. and Niefind,K.
    Crystal structure of highly glycosylated human leukocyte elastase in complex with an S2' site binding inhibitor
    Acta Crystallogr F Struct Biol Commun74, 480-489. PubMed  Europe PubMed DOI  S  I
  27. Kim,J.Y., Wang,Y., Uddin,Z., Song,Y.H., Li,Z.P., Jenis,J. and Park,K.H.
    Competitive neutrophil elastase inhibitory isoflavones from the roots of Flemingia philippinensis
    Bioorg Chem78, 249-257. PubMed  Europe PubMed DOI  I
  28. Kim,K.C., Kim,D.J., Lee,M.S., Seo,J.Y., Yoo,I.D. and Lee,I.S.
    Inhibition of human neutrophil elastase by sesquiterpene lactone dimers from the flowers of Inula britannica
    J Microbiol Biotechnol28, 1806-1813. PubMed  Europe PubMed DOI  I
  29. Kumar,H., Choi,H., Jo,M.J., Joshi,H.P., Muttigi,M., Bonanomi,D., Kim,S.B., Ban,E., Kim,A., Lee,S.H., Kim,K.T., Sohn,S., Zeng,X. and Han,I.
    Neutrophil elastase inhibition effectively rescued angiopoietin-1 decrease and inhibits glial scar after spinal cord injury
    Acta Neuropathol Commun6, 73-73. PubMed  Europe PubMed DOI  I
  30. Marto,J., Ruivo,E., Lucas,S.D., Goncalves,L.M., Simoes,S., Gouveia,L.F., Felix,R., Moreira,R., Ribeiro,H.M. and Almeida,A.J.
    Starch nanocapsules containing a novel neutrophil elastase inhibitor with improved pharmaceutical performance
    Eur J Pharm Biopharm127, 1-11. PubMed  Europe PubMed DOI  I
  31. Schulz-Fincke,A.C., Tikhomirov,A.S., Braune,A., Girbl,T., Gilberg,E., Bajorath,J., Blaut,M., Nourshargh,S. and Gutschow,M.
    Design of an activity-based probe for human neutrophil elastase: implementation of the Lossen rearrangement to induce Forster resonance energy transfers
    Biochemistry57, 742-752. PubMed  Europe PubMed DOI  L  I
  32. Schulz-Fincke,A.C., Blaut,M., Braune,A. and Gutschow,M.
    A BODIPY-tagged phosphono peptide as activity-based probe for human leukocyte elastase
    ACS Med Chem Lett9, 345-350. PubMed  Europe PubMed DOI  L  I
  33. Souwer,Y., Groot Kormelink,T., Taanman-Kueter,E.W., Muller,F.J., van Capel,T.M.M., Varga,D.V., Bar-Ephraim,Y.E., Teunissen,M.B.M., van Ham,S.M., Kuijpers,T.W., Wouters,D., Meyaard,L. and de Jong,E.C.
    Human Th17 cell development requires processing of dendritic cell-derived CXCL8 by neutrophil elastase
    J Allergy Clin Immunol141, 2286-2289. PubMed  Europe PubMed DOI  I
  34. Sullivan,G.P., Davidovich,P.B., Sura-Trueba,S., Belotcerkovskaya,E., Henry,C.M., Clancy,D.M., Zinoveva,A., Mametnabiev,T., Garabadzhiu,A.V. and Martin,S.J.
    Identification of small-molecule elastase inhibitors as antagonists of IL-36 cytokine activation
    FEBS Open Bio8, 751-763. PubMed  Europe PubMed DOI  I
  35. Wen,G., An,W., Chen,J., Maguire,E.M., Chen,Q., Yang,F., Pearce,S.W.A., Kyriakides,M., Zhang,L., Ye,S., Nourshargh,S. and Xiao,Q.
    Genetic and pharmacologic inhibition of the neutrophil elastase inhibits experimental atherosclerosis
    J Am Heart Assoc7, PubMed  Europe PubMed DOI  K  T  I
    36. 2017
  36. Bai,Y., Wang,H. and Zhao,Q.
    Detection of human neutrophil elastase by aptamer affinity capillary electrophoresis coupled with laser-induced fluorescence using specified site fluorescently labeled aptamer
    Anal Bioanal Chem409, 6843-6849. PubMed  Europe PubMed DOI  A  I
  37. Crocetti,L., Bartolucci,G., Cilibrizzi,A., Giovannoni,M.P., Guerrini,G., Iacovone,A., Menicatti,M., Schepetkin,I.A., Khlebnikov,A.I., Quinn,M.T. and Vergelli,C.
    Synthesis and analytical characterization of new thiazol-2-(3H)-ones as human neutrophil elastase (HNE) inhibitors
    Chem Cent J11, 127-127. PubMed  Europe PubMed DOI  I
  38. Lerman,I., Garcia-Hernandez,M.L., Rangel-Moreno,J., Chiriboga,L., Pan,C., Nastiuk,K.L., Krolewski,J.J., Sen,A. and Hammes,S.R.
    Infiltrating myeloid cells exert pro-tumorigenic actions via neutrophil elastase
    Mol Cancer Res15, 1138-1152. PubMed  Europe PubMed DOI  I
  39. Muley,M.M., Krustev,E., Reid,A.R. and McDougall,J.J.
    Prophylactic inhibition of neutrophil elastase prevents the development of chronic neuropathic pain in osteoarthritic mice
    J Neuroinflammation14, 168-168. PubMed  Europe PubMed DOI  I
  40. Vergelli,C., Schepetkin,I.A., Crocetti,L., Iacovone,A., Giovannoni,M.P., Guerrini,G., Khlebnikov,A.I., Ciattini,S., Ciciani,G. and Quinn,M.T.
    Isoxazol-5(2H)-one: a new scaffold for potent human neutrophil elastase (HNE) inhibitors
    J Enzyme Inhib Med Chem32, 821-831. PubMed  Europe PubMed DOI  I
    41. 2016
  41. Craciun,I., Fenner,A.M. and Kerns,R.J.
    N-Arylacyl O-sulfonated aminoglycosides as novel inhibitors of human neutrophil elastase, cathepsin G and proteinase 3
    Glycobiology26, 701-709. PubMed  Europe PubMed DOI  I
  42. Crocetti,L., Schepetkin,I.A., Ciciani,G., Giovannoni,M.P., Guerrini,G., Iacovone,A., Khlebnikov,A.I., Kirpotina,L.N., Quinn,M.T. and Vergelli,C.
    Synthesis and pharmacological evaluation of indole derivatives as deaza analogues of potent human neutrophil elastase inhibitors
    Drug Dev Res77, 285-299. PubMed  Europe PubMed DOI  I
  43. Di Cesare Mannelli,L., Micheli,L., Cinci,L., Maresca,M., Vergelli,C., Pacini,A., Quinn,M.T., Paola Giovannoni,M. and Ghelardini,C.
    Effects of the neutrophil elastase inhibitor EL-17 in rat adjuvant-induced arthritis
    Rheumatology (Oxford)55, 1285-1294. PubMed  Europe PubMed DOI  I
  44. Giovannoni,M.P., Schepetkin,I.A., Crocetti,L., Ciciani,G., Cilibrizzi,A., Guerrini,G., Khlebnikov,A.I., Quinn,M.T. and Vergelli,C.
    Cinnoline derivatives as human neutrophil elastase inhibitors
    J Enzyme Inhib Med Chem31, 628-639. PubMed  Europe PubMed DOI  I
  45. Ruivo,E.F., Goncalves,L.M., Carvalho,L.A., Guedes,R.C., Hofbauer,S., Brito,J.A., Archer,M., Moreira,R. and Lucas,S.D.
    Clickable 4-oxo-beta-lactam-based selective probing for human neutrophil elastase related proteomes
    ChemMedChem11, 2037-2042. PubMed  Europe PubMed DOI  L  I
  46. Tan,X.F., Kim,D.W., Song,Y.H., Kim,J.Y., Yuk,H.J., Wang,Y., Curtis-Long,M.J. and Park,K.H.
    Human neutrophil elastase inhibitory potential of flavonoids from Campylotropis hirtella and their kinetics
    J Enzyme Inhib Med Chem31, 16-22. PubMed  Europe PubMed DOI  I
  47. Thiede,S., Wosniok,P.R., Herkommer,D., Schulz-Fincke,A.C., Gutschow,M. and Menche,D.
    Total synthesis of leupyrrin B1: a potent inhibitor of human leukocyte elastase
    Org Lett18, 3964-3967. PubMed  Europe PubMed DOI  I
  48. von Nussbaum,F., Li,V.M., Meibom,D., Anlauf,S., Bechem,M., Delbeck,M., Gerisch,M., Harrenga,A., Karthaus,D., Lang,D., Lustig,K., Mittendorf,J., Schafer,M., Schafer,S. and Schamberger,J.
    Potent and selective human neutrophil elastase inhibitors with novel equatorial ring topology: in vivo efficacy of the polar pyrimidopyridazine BAY-8040 in a pulmonary arterial hypertension rat model
    ChemMedChem11, 199-206. PubMed  Europe PubMed DOI  I
    49. 2015
  49. Areias,L.R.P., Ruivo,E.F.P., Goncalves,L.M., Duarte,M.T., Andre,V., Moreira,R., Lucas,S.D. and Guedes,R.C.
    A unified approach toward the rational design of selective low nanomolar human neutrophil elastase inhibitors
    RSC Adv5, 51717-51721. DOI  I
  50. Gregory,A.D., Kliment,C.R., Metz,H.E., Kim,K.H., Kargl,J., Agostini,B.A., Crum,L.T., Oczypok,E.A., Oury,T.A. and Houghton,A.M.
    Neutrophil elastase promotes myofibroblast differentiation in lung fibrosis
    J Leukoc Biol98, 143-152. PubMed  Europe PubMed DOI  K  I
  51. Guillaume,D., Huynh,T.N., Clement Denhez, Nguyen,K.P. and Belaaouaj,A.
    Triterpenoids as neutrophil elastase inhibitors
    Nat Prod Commun10, 167-170. PubMed  Europe PubMed  I
  52. Huang,G., Feng,L., Liu,B., He,Y., Li,Y. and Chen,Y.
    Synthesis and biological evaluation of nigranoic acid esters as novel human neutrophil elastase inhibitors
    Nat Prod Res29, 1650-1656. PubMed  Europe PubMed DOI  I
  53. Hwang,T.L., Wang,W.H., Wang,T.Y., Yu,H.P. and Hsieh,P.W.
    Synthesis and pharmacological characterization of 2-aminobenzaldehyde oxime analogs as dual inhibitors of neutrophil elastase and proteinase 3
    Bioorg Med Chem23, 1123-1134. PubMed  Europe PubMed DOI  I
  54. Jiang,K.L., Ma,P.P., Yang,X.Q., Zhong,L., Wang,H., Zhu,X.Y. and Liu,B.Z.
    Neutrophil elastase and its therapeutic effect on leukemia cells
    Mol Med Rep12, 4165-4172. PubMed  Europe PubMed DOI  I
  55. Lechtenberg,B.C., Kasperkiewicz,P., Robinson,H., Drag,M. and Riedl,S.J.
    The elastase-PK101 structure: mechanism of an ultrasensitive activity-based probe revealed
    ACS Chem Biol10, 945-951. PubMed  Europe PubMed DOI  S  I
  56. Lee,I.S., Kim,K.C., Yoo,I.D. and Ha,B.J.
    Inhibition of human neutrophil elastase by labdane diterpenes from the fruiting bodies of Ramaria formosa
    Biosci Biotechnol Biochem79, 1921-1925. PubMed  Europe PubMed DOI  I
  57. Tsai,Y.F. and Hwang,T.L.
    Neutrophil elastase inhibitors: a patent review and potential applications for inflammatory lung diseases (2010 - 2014)
    Expert Opin Ther Pat25, 1145-1158. PubMed  Europe PubMed DOI  V  I
  58. Tsai,Y.F., Yu,H.P., Chang,W.Y., Liu,F.C., Huang,Z.C. and Hwang,T.L.
    Sirtinol inhibits neutrophil elastase activity and attenuates lipopolysaccharide-mediated acute lung injury in mice
    Sci Rep5, 8347-8347. PubMed  Europe PubMed DOI  I
  59. Vicuna,L., Strochlic,D.E., Latremoliere,A., Bali,K.K., Simonetti,M., Husainie,D., Prokosch,S., Riva,P., Griffin,R.S., Njoo,C., Gehrig,S., Mall,M.A., Arnold,B., Devor,M., Woolf,C.J., Liberles,S.D., Costigan,M. and Kuner,R.
    The serine protease inhibitor serpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase
    Nat Med21, 518-523. PubMed  Europe PubMed DOI  I
  60. von Nussbaum,F., Li,V.M., Allerheiligen,S., Anlauf,S., Barfacker,L., Bechem,M., Delbeck,M., Fitzgerald,M.F., Gerisch,M., Gielen-Haertwig,H., Haning,H., Karthaus,D., Lang,D., Lustig,K., Meibom,D., Mittendorf,J., Rosentreter,U., Schafer,M., Schafer,S., Schamberger,J., Telan,L.A. and Tersteegen,A.
    Freezing the bioactive conformation to boost potency: the identification of BAY 85-8501, a selective and potent inhibitor of human neutrophil elastase for pulmonary diseases
    ChemMedChem10, 1163-1173. PubMed  Europe PubMed DOI  I
  61. von Nussbaum,F. and Li,V.M.
    Neutrophil elastase inhibitors for the treatment of (cardio)pulmonary diseases: into clinical testing with pre-adaptive pharmacophores
    Bioorg Med Chem Lett25, 4370-4381. PubMed  Europe PubMed DOI  V  I
  62. Weyer,A.D. and Stucky,C.L.
    Repurposing a leukocyte elastase inhibitor for neuropathic pain
    Nat Med21, 429-430. PubMed  Europe PubMed DOI  I
    63. 2014
  63. Abdel-Magid,A.F.
    Neutrophil elastase inhibitors as potential anti-inflammatory therapies
    ACS Med Chem Lett5, 1182-1183. PubMed  Europe PubMed DOI  I
  64. Grzywa,R., Burchacka,E., Lecka,M., Winiarski,L., Walczak,M., Lupicka-Slowik,A., Wysocka,M., Burster,T., Bobrek,K., Csencsits-Smith,K., Lesner,A. and Sienczyk,M.
    Synthesis of novel phosphonic-type activity-based probes for neutrophil serine proteases and their application in spleen lysates of different organisms
    Chembiochem15, 2605-2612. PubMed  Europe PubMed DOI  I
  65. Habash,M., Abdelazeem,A.H. and Taha,M.O.
    Elaborate ligand-based modeling reveals new human neutrophil elastase inhibitors
    Med Chem Res23, 3876-3896. DOI  I
  66. Shioya,Y., Katakura,K. and Ohira,H.
    Neutrophil elastase inhibitor suppresses IL-17 based inflammation of murine experimental colitis
    Fukushima J Med Sci60, 14-21. PubMed  Europe PubMed  I
    67. 2013
  67. Cheng,L. and Zhao,Q.
    Aptamer-capture based assays for human neutrophil elastase
    Talanta106, 315-320. PubMed  Europe PubMed DOI  I
  68. Crocetti,L., Schepetkin,I.A., Cilibrizzi,A., Graziano,A., Vergelli,C., Giomi,D., Khlebnikov,A.I., Quinn,M.T. and Giovannoni,M.P.
    Optimization of N-benzoylindazole derivatives as inhibitors of human neutrophil elastase
    J Med Chem56, 6259-6272. PubMed  Europe PubMed DOI  I
  69. Feng,L., Liu,X., Zhu,W., Guo,F., Yingchunwu, Wang,R., Chen,K., Huang,C. and Li,Y.
    Inhibition of human neutrophil elastase by pentacyclic triterpenes
    PLoS ONE8, e82794-e82794. PubMed  Europe PubMed DOI  I
  70. Mansuy-Aubert,V., Zhou,Q.L., Xie,X., Gong,Z., Huang,J.Y., Khan,A.R., Aubert,G., Candelaria,K., Thomas,S., Shin,D.J., Booth,S., Baig,S.M., Bilal,A., Hwang,D., Zhang,H., Lovell-Badge,R., Smith,S.R., Awan,F.R. and Jiang,Z.Y.
    Imbalance between neutrophil elastase and its inhibitor alpha1-antitrypsin in obesity alters insulin sensitivity, inflammation, and energy expenditure
    Cell Metab17, 534-548. PubMed  Europe PubMed DOI  I
  71. Montalbano,F., Cal,P.M., Carvalho,M.A., Goncalves,L.M., Lucas,S.D., Guedes,R.C., Veiros,L.F., Moreira,R. and Gois,P.M.
    Discovery of new heterocycles with activity against human neutrophile elastase based on a boron promoted one-pot assembly reaction
    Org Biomol Chem11, 4465-4472. PubMed  Europe PubMed DOI  I
  72. Narayanaswamy,R., Wai,L.K. and Ismail,I.S.
    Molecular docking analysis of natural compounds as human neutrophil elastase (HNE) inhibitors
    J Chem Pharm Res5, 337-341.  I
  73. Salvador,L.A., Taori,K., Biggs,J.S., Jakoncic,J., Ostrov,D.A., Paul,V.J. and Luesch,H.
    Potent elastase inhibitors from cyanobacteria: structural basis and mechanisms mediating cytoprotective and anti-inflammatory effects in bronchial epithelial cells
    J Med Chem56, 1276-1290. PubMed  Europe PubMed DOI  I
  74. Stockley,R., De Soyza,A., Gunawardena,K., Perrett,J., Forsman-Semb,K., Entwistle,N. and Snell,N.
    Phase II study of a neutrophil elastase inhibitor (AZD9668) in patients with bronchiectasis
    Respir Med107, 524-533. PubMed  Europe PubMed DOI  I
  75. Yoshikawa,N., Inomata,T., Okada,Y., Shimbo,T., Takahashi,M., Akita,K., Uesugi,Y. and Narumi,Y.
    Sivelestat sodium hydrate reduces radiation-induced lung injury in mice by inhibiting neutrophil elastase
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    76. 2012
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