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Literature for peptidase M01.004: leukotriene A4 hydrolase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(References are filtered for relevance to Inhibitor. To remove the filter click here. See explanation.)

    2017
  1. Numao,S., Hasler,F., Laguerre,C., Srinivas,H., Wack,N., Jager,P., Schmid,A., Osmont,A., Rothlisberger,P., Houguenade,J., Bergsdorf,C., Dawson,J., Carte,N., Hofmann,A., Markert,C., Hardaker,L., Billich,A., Wolf,R.M., Penno,C.A., Bollbuck,B., Miltz,W. and Rohn,T.A.
    Feasibility and physiological relevance of designing highly potent aminopeptidase-sparing leukotriene A4 hydrolase inhibitors
    Sci Rep7, 13591-13591. PubMed  Europe PubMed DOI  I
  2. Torres,M.J., Fierro,A., Pessoa-Mahana,C.D., Romero-Parra,J., Cabrera,G. and Faundez,M.
    Effect of alpha lipoic acid on leukotriene A4 hydrolase
    Eur J Pharmacol799, 41-47. PubMed  Europe PubMed DOI  I
  3. Zhang,F., Wu,D., Wang,G.-L., Hou,S., Ou-Yang,P., Huang,J. and Xu,X.-Y.
    Synthesis and biological evaluation of novel 1,2,3-benzotriazin-4-one derivatives as leukotriene A4 hydrolase aminopeptidase inhibitors
    Chin Chem Lett28, 1044-1048. DOI  I
    4. 2016
  4. Wittmann,S.K., Kalinowsky,L., Kramer,J.S., Bloecher,R., Knapp,S., Steinhilber,D., Pogoryelov,D., Proschak,E. and Heering,J.
    Thermodynamic properties of leukotriene A4 hydrolase inhibitors
    Bioorg Med Chem24, 5243-5248. PubMed  Europe PubMed DOI  I
  5. Xiao,Q., Dong,N., Yao,X., Wu,D., Lu,Y., Mao,F., Zhu,J., Li,J., Huang,J., Chen,A., Huang,L., Wang,X., Yang,G., He,G., Xu,Y. and Lu,W.
    Bufexamac ameliorates LPS-induced acute lung injury in mice by targeting LTA4H
    Sci Rep6, 25298-25298. PubMed  Europe PubMed DOI  I
    6. 2015
  6. Paz,P.B., Vega-Hissi,E.G., Andrada,M.F., Estrada,M.R. and Garro Martinez,J.C.
    Quantitative structure activity relationship and binding investigation of N-alkyl glycine amides as inhibitors of leukotriene A4 hydrolase
    Med Chem Res24, 496-504. DOI  I
    7. 2014
  7. Barchuk,W., Lambert,J., Fuhr,R., Jiang,J.Z., Bertelsen,K., Fourie,A., Liu,X., Silkoff,P.E., Barnathan,E.S. and Thurmond,R.
    Effects of JNJ-40929837, a leukotriene A4 hydrolase inhibitor, in a bronchial allergen challenge model of asthma
    Pulm Pharmacol Ther29, 15-23. PubMed  Europe PubMed DOI  I
  8. Hitzerd,S.M., Verbrugge,S.E., Ossenkoppele,G., Jansen,G. and Peters,G.J.
    Positioning of aminopeptidase inhibitors in next generation cancer therapy
    Amino Acids46, 793-808. PubMed  Europe PubMed DOI  I
  9. Stsiapanava,A., Olsson,U., Wan,M., Kleinschmidt,T., Rutishauser,D., Zubarev,R.A., Samuelsson,B., Rinaldo-Matthis,A. and Haeggstrom,J.Z.
    Binding of Pro-Gly-Pro at the active site of leukotriene A4 hydrolase/aminopeptidase and development of an epoxide hydrolase selective inhibitor
    Proc Natl Acad Sci U S A111, 4227-4232. PubMed  Europe PubMed DOI  S  I
    10. 2013
  10. Caliskan,B. and Banoglu,E.
    Overview of recent drug discovery approaches for new generation leukotriene A4 hydrolase inhibitors
    Expert Opin Drug Discov8, 49-63. PubMed  Europe PubMed DOI  V  I
  11. Eccles,W., Blevitt,J.M., Booker,J.N., Chrovian,C.C., Crawford,S., de Leon,A.R., Deng,X., Fourie,A.M., Grice,C.A., Herman,K., Karlsson,L., Kearney,A.M., Lee-Dutra,A., Liang,J., Luna,R., Pippel,D., Rao,N., Riley,J.P., Santillan,A., Savall,B., Tanis,V.M., Xue,X. and Young,A.L.
    Identification of benzofuran central cores for the inhibition of leukotriene A(4) hydrolase
    Bioorg Med Chem Lett23, 811-815. PubMed  Europe PubMed DOI  I
  12. Meng,H., Liu,Y., Zhai,Y. and Lai,L.
    Optimization of 5-hydroxytryptamines as dual function inhibitors targeting phospholipase A2 and leukotriene A4 hydrolase
    Eur J Med Chem59, 160-167. PubMed  Europe PubMed DOI  I
  13. Thangapandian,S., John,S., Son,M., Arulalapperumal,V. and Lee,K.W.
    Development of predictive quantitative structure-activity relationship model and its application in the discovery of human leukotriene A4 hydrolase inhibitors
    Future Med Chem5, 27-40. PubMed  Europe PubMed DOI  I
    14. 2012
  14. Tanis,V.M., Bacani,G.M., Blevitt,J.M., Chrovian,C.C., Crawford,S., De Leon,A., Fourie,A.M., Gomez,L., Grice,C.A., Herman,K., Kearney,A.M., Landry-Bayle,A.M., Lee-Dutra,A., Nelson,J., Riley,J.P., Santillan,A., Jr., Wiener,J.J., Xue,X. and Young,A.L.
    Azabenzthiazole inhibitors of leukotriene A4 hydrolase
    Bioorg Med Chem Lett22, 7504-7511. PubMed  Europe PubMed DOI  I
    15. 2011
  15. Thangapandian,S., John,S., Sakkiah,S. and Lee,K.W.
    Pharmacophore-based virtual screening and Bayesian model for the identification of potential human leukotriene A4 hydrolase inhibitors
    Eur J Med Chem46, 1593-1603. PubMed  Europe PubMed DOI  I
  16. Thangapandian,S., John,S., Sakkiah,S. and Lee,K.W.
    Molecular docking and pharmacophore filtering in the discovery of dual-inhibitors for human leukotriene A4 hydrolase and leukotriene C4 synthase
    J Chem Inf Model51, 33-44. PubMed  Europe PubMed DOI  I
    17. 2010
  17. Oi,N., Jeong,C.H., Nadas,J., Cho,Y.Y., Pugliese,A., Bode,A.M. and Dong,Z.
    Resveratrol, a red wine polyphenol, suppresses pancreatic cancer by inhibiting leukotriene A4 hydrolase
    Cancer Res70, 9755-9764. PubMed  Europe PubMed DOI  I
  18. Rao,N.L., Riley,J.P., Banie,H., Xue,X., Sun,B., Crawford,S., Lundeen,K.A., Yu,F., Karlsson,L., Fourie,A.M. and Dunford,P.J.
    Leukotriene A(4) hydrolase inhibition attenuates allergic airway inflammation and hyperresponsiveness
    Am J Respir Crit Care Med181, 899-907. PubMed  Europe PubMed DOI  I
  19. Sandanayaka,V., Mamat,B., Bhagat,N., Bedell,L., Halldorsdottir,G., Sigthorsdottir,H., Andresson,T., Kiselyov,A., Gurney,M. and Singh,J.
    Discovery of novel leukotriene A4 hydrolase inhibitors based on piperidine and piperazine scaffolds
    Bioorg Med Chem Lett20, 2851-2854. PubMed  Europe PubMed DOI  I
  20. Sandanayaka,V., Mamat,B., Mishra,R.K., Winger,J., Krohn,M., Zhou,L.M., Keyvan,M., Enache,L., Sullins,D., Onua,E., Zhang,J., Halldorsdottir,G., Sigthorsdottir,H., Thorlaksdottir,A., Sigthorsson,G., Thorsteinnsdottir,M., Davies,D.R., Stewart,L.J., Zembower,D.E., Andresson,T., Kiselyov,A.S., Singh,J. and Gurney,M.E.
    Discovery of 4-[(2S)-2-{[4-(4-chlorophenoxy)phenoxy]methyl}-1-pyrrolidinyl]butanoic acid (DG-051) as a novel leukotriene A4 hydrolase inhibitor of leukotriene B4 biosynthesis
    J Med Chem53, 573-585. PubMed  Europe PubMed DOI  I
  21. Sonawane,L.V. and Bari,S.B.
    QSAR, docking studies and pharmacophore identification of phenylmethyl phenoxy propyl amino propanoic acid derivatives as leukotriene A4 hydrolase inhibitors
    Yao Xue Xue Bao45, 615-623. PubMed  Europe PubMed  I
  22. Tholander,F., Roques,B.P., Fournie-Zaluski,M.C., Thunnissen,M.M. and Haeggstrom,J.Z.
    Crystal structure of leukotriene A4 hydrolase in complex with kelatorphan, implications for design of zinc metallopeptidase inhibitors
    FEBS Lett584, 3446-3451. PubMed  Europe PubMed DOI  S  I
    23. 2009
  23. Davies,D.R., Mamat,B., Magnusson,O.T., Christensen,J., Haraldsson,M.H., Mishra,R., Pease,B., Hansen,E., Singh,J., Zembower,D., Kim,H., Kiselyov,A.S., Burgin,A.B., Gurney,M.E. and Stewart,L.J.
    Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography
    J Med Chem52, 4694-4715. PubMed  Europe PubMed DOI  I
  24. Enomoto,H., Morikawa,Y., Miyake,Y., Tsuji,F., Mizuchi,M., Suhara,H., Fujimura,K., Horiuchi,M. and Ban,M.
    Synthesis and biological evaluation of N-mercaptoacylcysteine derivatives as leukotriene A4 hydrolase inhibitors
    Bioorg Med Chem Lett19, 442-446. PubMed  Europe PubMed DOI  I
  25. Fourie,A.M.
    Modulation of inflammatory disease by inhibitors of leukotriene A4 hydrolase
    Curr Opin Investig Drugs10, 1173-1182. PubMed  Europe PubMed  V  I
  26. Jeong,C.H., Bode,A.M., Pugliese,A., Cho,Y.Y., Kim,H.G., Shim,J.H., Jeon,Y.J., Li,H., Jiang,H. and Dong,Z.
    [6]-Gingerol suppresses colon cancer growth by targeting leukotriene A4 hydrolase
    Cancer Res69, 5584-5591. PubMed  Europe PubMed DOI  I
    27. 2008
  27. Enomoto,H., Morikawa,Y., Miyake,Y., Tsuji,F., Mizuchi,M., Suhara,H., Fujimura,K., Horiuchi,M. and Ban,M.
    Synthesis and biological evaluation of N-mercaptoacylproline and N-mercaptoacylthiazolidine-4-carboxylic acid derivatives as leukotriene A4 hydrolase inhibitors
    Bioorg Med Chem Lett18, 4529-4532. PubMed  Europe PubMed DOI  I
  28. Grice,C.A. and Gomez,L.
    Current status of leukotriene A4 hydrolase inhibitors
    Expert Opin Ther Pat18, 1333-1350. DOI  I
  29. Grice,C.A., Tays,K.L., Savall,B.M., Wei,J., Butler,C.R., Axe,F.U., Bembenek,S.D., Fourie,A.M., Dunford,P.J., Lundeen,K., Coles,F., Xue,X., Riley,J.P., Williams,K.N., Karlsson,L. and Edwards,J.P.
    Identification of a potent, selective, and orally active leukotriene A4 hydrolase inhibitor with anti-inflammatory activity
    J Med Chem51, 4150-4169. PubMed  Europe PubMed DOI  I
  30. Jiang,X., Zhou,L., Wei,D., Meng,H., Liu,Y. and Lai,L.
    Activation and inhibition of leukotriene A4 hydrolase aminopeptidase activity by diphenyl ether and derivatives
    Bioorg Med Chem Lett18, 6549-6552. PubMed  Europe PubMed DOI  I
  31. Khim,S.K., Bauman,J., Evans,J., Freeman,B., King,B., Kirkland,T., Kochanny,M., Lentz,D., Liang,A., Mendoza,L., Phillips,G., Tseng,J.L., Wei,R.G., Ye,H., Yu,L., Parkinson,J. and Guilford,W.J.
    Discovery of novel and potent aryl diamines as leukotriene A4 hydrolase inhibitors
    Bioorg Med Chem Lett18, 3895-3898. PubMed  Europe PubMed DOI  I
  32. Kirkland,T.A., Adler,M., Bauman,J.G., Chen,M., Haeggstrom,J.Z., King,B., Kochanny,M.J., Liang,A.M., Mendoza,L., Phillips,G.B., Thunnissen,M., Trinh,L., Whitlow,M., Ye,B., Ye,H., Parkinson,J. and Guilford,W.J.
    Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase
    Bioorg Med Chem16, 4963-4983. PubMed  Europe PubMed DOI  I
  33. Whittle,B.J., Varga,C., Berko,A., Horvath,K., Posa,A., Riley,J.P., Lundeen,K.A., Fourie,A.M. and Dunford,P.J.
    Attenuation of inflammation and cytokine production in rat colitis by a novel selective inhibitor of leukotriene A4 hydrolase
    Br J Pharmacol153, 983-991. PubMed  Europe PubMed DOI  I
  34. Ye,B., Bauman,J., Chen,M., Davey,D., Khim,S.K., King,B., Kirkland,T., Kochanny,M., Liang,A., Lentz,D., May,K., Mendoza,L., Phillips,G., Selchau,V., Schlyer,S., Tseng,J.L., Wei,R.G., Ye,H., Parkinson,J. and Guilford,W.J.
    Synthesis of N-alkyl glycine amides as potent inhibitors of leukotriene A4 hydrolase
    Bioorg Med Chem Lett18, 3891-3894. PubMed  Europe PubMed DOI  I
    35. 2007
  35. Rao,N.L., Dunford,P.J., Xue,X., Jiang,X., Lundeen,K.A., Coles,F., Riley,J.P., Williams,K.N., Grice,C.A., Edwards,J.P., Karlsson,L. and Fourie,A.M.
    Anti-inflammatory activity of a potent, selective leukotriene A4 hydrolase inhibitor in comparison with the 5-lipoxygenase inhibitor zileuton
    J Pharmacol Exp Ther321, 1154-1160. PubMed  Europe PubMed DOI  I
    36. 2004
  36. Chen,X., Wang,S., Wu,N. and Yang,C.S.
    Leukotriene A4 hydrolase as a target for cancer prevention and therapy
    Curr Cancer Drug Targets4, 267-283. PubMed  Europe PubMed DOI  I
    37. 2002
  37. Askonas,L.J., Kachur,J.F., Villani-Price,D., Liang,C.D., Russell,M.A. and Smith,W.G.
    Pharmacological characterization of SC-57461A (3-[methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic acid HCl), a potent and selective inhibitor of leukotriene A(4) hydrolase I: in vitro studies
    J Pharmacol Exp Ther300, 577-582. PubMed  Europe PubMed DOI  I
  38. Kachur,J.F., Askonas,L.J., Villani-Price,D., Ghoreishi-Haack,N., Won-Kim,S., Liang,C.D., Russell,M.A. and Smith,W.G.
    Pharmacological characterization of SC-57461A (3-[methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic acid HCl), a potent and selective inhibitor of leukotriene A(4) hydrolase II: in vivo studies
    J Pharmacol Exp Ther300, 583-587. PubMed  Europe PubMed DOI  I
  39. [YEAR:2-12-2002]Penning,T.D., Chandrakumar,N.S., Desai,B.N., Djuric,S.W., Gasiecki,A.F., Liang,C.D., Miyashiro,J.M., Russell,M.A., Askonas,L.J., Gierse,J.K., Harding,E.I., Highkin,M.K., Kachur,J.F., Kim,S.H., Villani-Price,D., Pyla,E.Y., Ghoreishi-Haack,N.S. and Smith,W.G.
    Pyrrolidine and piperidine analogues of SC-57461A as potent, orally active inhibitors of leukotriene A(4) hydrolase
    Bioorg Med Chem Lett12, 3383-3386. PubMed  Europe PubMed DOI  I
  40. Thunnissen,M.M., Andersson,B., Samuelsson,B., Wong,C.H. and Haeggstrom,J.Z.
    Crystal structures of leukotriene A4 hydrolase in complex with captopril and two competitive tight-binding inhibitors
    FASEB J16, 1648-1650. PubMed  Europe PubMed DOI  S  I
    41. 2001
  41. Penning,T.D.
    Inhibitors of leukotriene A4 (LTA4) hydrolase as potential anti-inflammatory agents
    Curr Pharm Des7, 163-179. PubMed  Europe PubMed DOI  V  I
  42. Thunnissen,M.M., Nordlund,P. and Haeggstrom,J.Z.
    Crystal structure of human leukotriene A(4) hydrolase, a bifunctional enzyme in inflammation
    Nat Struct Biol8, 131-135. PubMed  Europe PubMed DOI  S  I
    43. 2000
  43. [YEAR:1-2-2000]Andberg,M., Wetterholm,A., Medina,J.F. and Haeggstrom,J.Z.
    Leukotriene A4 hydrolase: a critical role of glutamic acid-296 for the binding of bestatin
    Biochem J345, 621-625. PubMed  Europe PubMed DOI  I
    44. 1998
  44. Hogg,J.H., Ollmann,I.R., Wetterholm,A., Andberg,M.B., Haeggstrom,J., Samuelsson,B. and Wong,C.H.
    Probing the activities and mechanisms of leukotriene A4 hydrolase with synthetic inhibitors
    Chemistry4, 1698-1713. DOI  I
    45. 1994
  45. Muskardin,D.T., Voelkel,N.F. and Fitzpatrick,F.A.
    Modulation of pulmonary leukotriene formation and perfusion pressure by bestatin, an inhibitor of leukotriene A4 hydrolase
    Biochem Pharmacol48, 131-137. PubMed  Europe PubMed DOI  I
  46. Orning,L., Gierse,J.K. and Fitzpatrick,F.A.
    The bifunctional enzyme leukotriene-A4 hydrolase is an arginine aminopeptidase of high efficiency and specificity
    J Biol Chem269, 11269-11273. PubMed  Europe PubMed  I
  47. Tsuge,H., Ago,H., Aoki,M., Furuno,M., Noma,M., Miyano,M., Minami,M., Izumi,T. and Shimizu,T.
    Crystallization and preliminary x-ray crystallographic studies of recombinant human leukotriene A4 hydrolase complexed with bestatin
    J Mol Biol238, 854-856. PubMed  Europe PubMed DOI  S  I
    48. 1992
  48. Djuric,S.W., Huff,R.M., Penning,T.D., Clare,M., Swenton,L., Kachur,J.F., Villani-Price,D., Krivi,G.G., Pyla,E.Y. and Warren,T.G.
    Synthesis and pharmacological activity of rationally designed inhibitors of the leukotriene A4 hydrolase enzyme
    Bioorg Med Chem Lett2, 1353-1356.  I
    49. 1991
  49. [YEAR:25-1-1991]Orning,L., Krivi,G. and Fitzpatrick,F.A.
    Leukotriene A4 hydrolase. Inhibition by bestatin and intrinsic aminopeptidase activity establish its functional resemblance to metallohydrolase enzymes
    J Biol Chem266, 1375-1378. PubMed  Europe PubMed  I

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