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Literature for peptidase C01.060: cathepsin B

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors Pharma

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    2025
  1. Porzberg,M.R.B., Groenewold,G.J.M., Lyoo,H., Jakob,A.K.M.H., Titulaer,W.H.C., Cavina,L., Poelaert,K.C.K., Zwaagstra,M., Dieteren,C.E.J., Lemmers,J.G.H., Hamdani,S.H., van Buuren,B.N.M., Ackerschott,B., Platteeuw,J., Michorius,J., Martina,B.E.E., Feiters,M.C., Girones,D., van Kuppeveld,F.J.M., van Hemert,M.J. and Rutjes,F.P.J.T.
    Peptidomimetic Phenoxymethyl Ketone Warheads as Potent Dual-Mode Inhibitors against SARS-CoV-2 M(pro) and Cathepsin
    J Med Chem (2025) PubMed  Europe PubMed DOI  I
  2. Yang,X., Cea-Medina,P., Gopalswamy,M., Vaidya,A., Schavier,S., Oltzen,S., Mossner,S., Huang,A., Qi,J., Holken,J.M., Teusch,N., Floss,D.M., Uhrberg,M., Gohlke,H. and Scheu,S.
    The mycotoxin Beauvericin is an uncompetitive inhibitor of Cathepsin B
    Protein Sci (2025) 34, e70173-e70173. PubMed  Europe PubMed DOI  PMC  EPMC  I
    3. 2024
  3. Jangra,S., Raghav,N., Wadhwa,D., Kumar,A., Bhattacharyya,S., Kumar,V. and Sheokand,J.
    Biological evaluation of trans-2,3-dihydrofuro[3,2-c]coumarins as potential cathepsin inhibitors and anticancer agents
    J Biomater Sci Polym Ed (2024) , 1-19. PubMed  Europe PubMed DOI  I
  4. Kumar,A., Rani,M., Giovannuzzi,S., Raghav,N., Supuran,C.T. and Sharma,P.K.
    Novel thiazolotriazole and triazolothiadiazine scaffolds as selective tumor associated carbonic anhydrase inhibitors endowed with cathepsin B inhibition
    Arch Pharm (Weinheim) (2024) , e2400366-e2400366. PubMed  Europe PubMed DOI  I
  5. Nandhini,M., Pitchumani Violet Mary,C., Gopinath,S. and Vijayakumar,S.
    Structure based interaction and molecular dynamics studies of cysteine protease Cathepsin B against curcumin and resveratrol
    J Biomol Struct Dyn (2024) , 1-11. PubMed  Europe PubMed DOI  I
  6. Siwach,K., Arya,P., Vats,L., Sharma,V., Giovannuzzi,S., Raghav,N., Supuran,C.T. and Sharma,P.K.
    Benzenesulfonamides functionalized with triazolyl-linked pyrazoles possess dual cathepsin B and carbonic anhydrase inhibitory action
    Arch Pharm (Weinheim) (2024) , e2400114-e2400114. PubMed  Europe PubMed DOI  I
  7. Siwach,K., Rani,M., Vats,L., Giovannuzzi,S., Paul,A.K., Brahma,M., Kumari,N., Maruthi,M., Raghav,N., Supuran,C.T. and Sharma,P.K.
    1,2,3-Triazole-based esters and carboxylic acids as nonclassical carbonic anhydrase inhibitors capable of cathepsin B inhibition
    Arch Pharm (Weinheim) (2024) 357, e2300372-e2300372. PubMed  Europe PubMed DOI  I
  8. Vashisth,C., Kaushik,T., Vashisth,N. and Raghav,N.
    Cinnamaldehyde hydrazone derivatives as potential cathepsin B inhibitors: parallel in-vitro investigation in liver and cerebrospinal fluid
    Int J Biol Macromol (2024) 272, 132684-132684. PubMed  Europe PubMed DOI  I
  9. Vashisth,C., Verma,N.K., Afshari,M., Bendi,A. and Raghav,N.
    In silico and in vitro validation of cinnamaldehyde as a potential cathepsin B inhibitor
    Chem Biodivers (2024) , e202401985-e202401985. PubMed  Europe PubMed DOI  I
  10. Yadav,S., Vashisth,C., Chaudhri,V., Singh,K., Raghav,N. and Pundeer,R.
    Development of potential cathepsin B inhibitors: Synthesis of new bithiazole derivatives, in vitro studies supported with theoretical docking studies
    Int J Biol Macromol (2024) 281, 136290-136290. PubMed  Europe PubMed DOI  I
    11. 2022
  11. Yoon,M.C., Christy,M.P., Phan,V.V., Gerwick,W.H., Hook,G., O'Donoghue,A.J. and Hook,V.
    Molecular Features of CA-074 pH-Dependent Inhibition of Cathepsin B
    Biochemistry (2022) 61, 228-238. PubMed  Europe PubMed DOI  I
    12. 2021
  12. Gu,Y., Zhu,Y., Deng,G., Liu,S., Sun,Y. and Lv,W.
    Curcumin analogue AI-44 alleviates MSU-induced gouty arthritis in mice via inhibiting cathepsin B-mediated NLRP3 inflammasome activation
    Int Immunopharmacol (2021) 93, 107375-107375. PubMed  Europe PubMed DOI  I
  13. Huang,Y., Chen,Z., Gu,Q., Gu,Z., Wu,X. and Yu,X.
    CA-074Me inhibits cathepsin-B and alleviates fibrosis after myocardial infarction
    Panminerva Med (2021) 63, 397-398. PubMed  Europe PubMed DOI  U  I
  14. Wang,J., Wang,L., Zhang,X., Xu,Y., Chen,L., Zhang,W., Liu,E., Xiao,C. and Kou,Q.
    Cathepsin B aggravates acute pancreatitis by activating the NLRP3 inflammasome and promoting the caspase-1-induced pyroptosis
    Int Immunopharmacol (2021) 94, 107496-107496. PubMed  Europe PubMed DOI  I
    15. 2020
  15. Abhinand,C.S., Nair,A.S., Krishnamurthy,A., Oommen,O.V. and Sudhakaran,P.R.
    Potential protease inhibitors and their combinations to block SARS-CoV-2
    J Biomol Struct Dyn (2020) , 1-15. PubMed  Europe PubMed DOI  PMC  EPMC  I
  16. Han,L., Xu,D., Xi,Z., Wu,M., Nik Nabil,W.N., Zhang,J., Sui,H., Fu,W., Zhou,H., Lao,Y., Xu,G., Guo,C. and Xu,H.
    The Natural Compound Oblongifolin C Exhibits Anticancer Activity by Inhibiting HSPA8 and Cathepsin B In Vitro
    Front Pharmacol (2020) 11, 564833-564833. PubMed  Europe PubMed DOI  PMC  EPMC  I
  17. Jastaniah,A., Gaisina,I.N., Knopp,R.C. and Thatcher,G.R.J.
    Synthesis of alpha-Ketoamide-Based Stereoselective Calpain-1 Inhibitors as Neuroprotective Agents
    ChemMedChem (2020) PubMed  Europe PubMed DOI  I
  18. Jiang,M., Meng,J., Zeng,F., Qing,H., Hook,G., Hook,V., Wu,Z. and Ni,J.
    Cathepsin B inhibition blocks neurite outgrowth in cultured neurons by regulating lysosomal trafficking and remodeling
    J Neurochem (2020) PubMed  Europe PubMed DOI  I
  19. Matos,T.K.B., Batista,P.H.J., Dos Reis Rocho,F., De Vita,D., Pearce,N., Kellam,B., Montanari,C.A. and Leitao,A.
    Synthesis and matched molecular pair analysis of covalent reversible inhibitors of the cysteine protease CPB
    Bioorg Med Chem Lett (2020) 30, 127439-127439. PubMed  Europe PubMed DOI  I
  20. Mellott,D., Tseng,C.T., Drelich,A., Fajtova,P., Chenna,B.C., Kostomiris,D., Hsu,J.C., Zhu,J., Taylor,Z., Tat,V., Katzfuss,A., Li,L., Giardini,M.A., Skinner,D., Hirata,K., Beck,S., Carlin,A.F., Clark,A.E., Berreta,L., Maneval,D., Frueh,F., Hurst,B.L., Wang,H., Kocurek,K.I., Raushel,F.M., O'Donoghue,A., Siqueira-Neto,J.L., Meek,T.D. and McKerrow,J.H.
    A cysteine protease inhibitor blocks SARS-CoV-2 infection of human and monkey cells
    bioRxiv (2020) PubMed  Europe PubMed DOI  PMC  EPMC  I
  21. Peintner,L., Venkatraman,A., Waeldin,A., Hofherr,A., Busch,T., Voronov,A., Viau,A., Kuehn,E.W., Kottgen,M. and Borner,C.
    Loss of PKD1/polycystin-1 impairs lysosomal activity in a CAPN (calpain)-dependent manner
    Autophagy (2020) , 1-17. PubMed  Europe PubMed DOI  I
  22. Riaz,S., Abdulrahman,N., Uddin,S., Jabeen,A., Gadeau,A.P., Fliegel,L. and Mraiche,F.
    Anti-hypertrophic effect of Na(+)/H(+) exchanger-1 inhibition is mediated by reduced cathepsin B
    Eur J Pharmacol (2020) 888, 173420-173420. PubMed  Europe PubMed DOI  I
  23. Sharma,T., Harioudh,M.K., Kuldeep,J., Kumar,S., Banerjee,D., Ghosh,J.K. and Siddiqi,M.I.
    Identification of potential inhibitors of cathepsin-B using shape & pharmacophore-based virtual screening, molecular docking and explicit water thermodynamics
    Mol Inform (2020) 39, e1900023-e1900023. PubMed  Europe PubMed DOI  I
  24. Van de Walle,T., Briand,M., Mitrovic,A., Sosic,I., Gobec,S., Kos,J., Persoons,L., Daelemans,D., De Jonghe,S., Ubiparip,Z., Desmet,T., Van Hecke,K., Mangelinckx,S. and D'hooghe,M.
    Synthesis of Novel Nitroxoline Analogs with Potent Cathepsin B Exopeptidase Inhibitory Activity
    ChemMedChem (2020) 15, 2477-2490. PubMed  Europe PubMed DOI  I
    25. 2019
  25. Mitrovic,A., Kljun,J., Sosic,I., Ursic,M., Meden,A., Gobec,S., Kos,J. and Turel,I.
    Organoruthenated nitroxoline derivatives impair tumor cell invasion through inhibition of cathepsin B activity
    Inorg Chem (2019) 58, 12334-12347. PubMed  Europe PubMed DOI  I
  26. Toupin,N.P., Arora,K., Shrestha,P., Peterson,J.A., Fischer,L.J., Rajagurubandara,E., Podgorski,I., Winter,A.H. and Kodanko,J.J.
    BODIPY-Caged photoactivated inhibitors of cathepsin B flip the light switch on cancer cell apoptosis
    ACS Chem Biol (2019) 14, 2833-2840. PubMed  Europe PubMed DOI  I
  27. Zheng,L., Wu,X., Li,S., Liu,B. and Xue,D.
    Cathepsin B inhibitors block multiple radiation-induced side effects in C. elegans
    Cell Res (2019) 29, 1042-1045. PubMed  Europe PubMed DOI  I
    28. 2018
  28. Coleman,M.D., Ha,S.D., Haeryfar,S.M.M., Barr,S.D. and Kim,S.O.
    Cathepsin B plays a key role in optimal production of the influenza A virus
    J Virol Antivir Res (2018) 2018, 1-20. PubMed  Europe PubMed DOI  PMC  EPMC  I
  29. Dietze,R., Starzinski-Powitz,A., Scheiner-Bobis,G., Tinneberg,H.R., Meinhold-Heerlein,I. and Konrad,L.
    Lysophosphatidic acid triggers cathepsin B-mediated invasiveness of human endometriotic cells
    Biochim Biophys Acta Mol Cell Biol Lipids (2018) 1863, 1369-1377. PubMed  Europe PubMed DOI  I
  30. Gonzalez,E.A., Martins,G.R., Tavares,A.M.V., Viegas,M., Poletto,E., Giugliani,R., Matte,U. and Baldo,G.
    Cathepsin B inhibition attenuates cardiovascular pathology in mucopolysaccharidosis I mice
    Life Sci (2018) 196, 102-109. PubMed  Europe PubMed DOI  I
  31. Hartmann,S., Lopez Cruz,R., Alameh,S., Ho,C.C., Rabideau,A., Pentelute,B.L., Bradley,K.A. and Martchenko,M.
    Characterization of novel piperidine-based inhibitor of cathepsin B-dependent bacterial toxins and viruses
    ACS Infect Dis (2018) 4, 1235-1245. PubMed  Europe PubMed DOI  I
  32. Liang,S., Jiang,H., Shen,X.H., Zhang,J.B. and Kim,N.H.
    Inhibition of cathepsin B activity prevents deterioration in the quality of in vitro aged porcine oocytes
    Theriogenology (2018) 116, 103-111. PubMed  Europe PubMed DOI  I
  33. Llorente,P., Kristen,H., Sastre,I., Toledano-Zaragoza,A., Aldudo,J., Recuero,M. and Bullido,M.J.
    A free radical-generating system regulates amyloid oligomers: involvement of cathepsin B
    J Alzheimers Dis (2018) 66, 1397-1408. PubMed  Europe PubMed DOI  I
  34. Sosic,I., Mitrovic,A., Curic,H., Knez,D., Brodnik Zugelj,H., Stefane,B., Kos,J. and Gobec,S.
    Cathepsin B inhibitors: further exploration of the nitroxoline core
    Bioorg Med Chem Lett (2018) 28, 1239-1247. PubMed  Europe PubMed DOI  I
  35. Sun,Y., Carandang,R.R., Harada,Y., Okada,S., Yoshitake,K., Asakawa,S., Nogi,Y., Matsunaga,S. and Takada,K.
    Lactomycins A-C, dephosphorylated phoslactomycin derivatives that inhibit cathepsin B, from the marine-derived Streptomyces sp. ACT232
    Mar Drugs (2018) 16 PubMed  Europe PubMed DOI  I
    36. 2017
  36. Farizatto,K.L.G., Ikonne,U.S., Almeida,M.F., Ferrari,M.F.R. and Bahr,B.A.
    Abeta42-mediated proteasome inhibition and associated tau pathology in hippocampus are governed by a lysosomal response involving cathepsin B: evidence for protective crosstalk between protein clearance pathways
    PLoS ONE (2017) 12, e0182895-e0182895. PubMed  Europe PubMed DOI  I
  37. Li,Y.Y., Fang,J. and Ao,G.Z.
    Cathepsin B and L inhibitors: a patent review (2010 - present)
    Expert Opin Ther Pat (2017) 27, 643-656. PubMed  Europe PubMed DOI  V  I
  38. Mitrovic,A., Sosic,I., Kos,S., Tratar,U.L., Breznik,B., Kranjc,S., Mirkovic,B., Gobec,S., Lah,T., Sersa,G. and Kos,J.
    Addition of 2-(ethylamino)acetonitrile group to nitroxoline results in significantly improved anti-tumor activity in vitro and in vivo
    Oncotarget (2017) 8, 59136-59147. PubMed  Europe PubMed DOI  PMC  EPMC  I
  39. Shoji,A., Suenaga,Y., Hosaka,A., Ishida,Y., Yanagida,A. and Sugawara,M.
    Inhibitory assay for degradation of collagen IV by cathepsin B with a surface plasmon resonance sensor
    J Pharm Biomed Anal (2017) 145, 79-83. PubMed  Europe PubMed DOI  I
  40. Wu,Z., Ni,J., Liu,Y., Teeling,J.L., Takayama,F., Collcutt,A., Ibbett,P. and Nakanishi,H.
    Cathepsin B plays a critical role in inducing Alzheimer's disease-like phenotypes following chronic systemic exposure to lipopolysaccharide from Porphyromonas gingivalis in mice
    Brain Behav Immun (2017) 65, 350-361. PubMed  Europe PubMed DOI  I
  41. Zhang,X., Yang,X., Wang,H., Li,S., Guo,K., Jiang,D., Xiao,J. and Liang,D.
    Design, synthesis, and structure-activity relationship study of epoxysuccinyl-peptide derivatives as cathepsin B inhibitors
    Biol Pharm Bull (2017) 40, 1240-1246. PubMed  Europe PubMed DOI  I
    42. 2016
  42. Coman,A.G., Paraschivescu,C.C., Hadade,N.D., Juncu,A., Vlaicu,O., Popescu,C.-I. and Matache,M.
    New acyloxymethyl ketones: useful probes for cysteine protease profiling
    Synthesis (2016) 48, 3917-3923. DOI  I
  43. Mitrovic,A., Mirkovic,B., Sosic,I., Gobec,S. and Kos,J.
    Inhibition of endopeptidase and exopeptidase activity of cathepsin B impairs extracellular matrix degradation and tumour invasion
    Biol Chem (2016) 397, 165-174. PubMed  Europe PubMed DOI  I
  44. Mitrovic,A., Kljun,J., Sosic,I., Gobec,S., Turel,I. and Kos,J.
    Clioquinol-ruthenium complex impairs tumour cell invasion by inhibiting cathepsin B activity
    Dalton Trans (2016) 45, 16913-16921. PubMed  Europe PubMed DOI  I
  45. Raghav,N., Jangra,S., Kumar,A., Bhattacharyya,S., Wadhwa,D. and Sindhu,J.
    Cathepsin B, H and L inhibitors as cell proliferating agents: design, synthesis, computational and pharmacological studies of some novel 2-(2-naphthoyl)-6,6-dimethyl-3-aryl-2,3,6,7-tetrahydrobenzofuran-4(5H)-ones
    RSC Adv (2016) 6, 34588-34599. DOI  I
  46. Schmitz,J., Li,T., Bartz,U. and Gutschow,M.
    Cathepsin B inhibitors: combining dipeptide nitriles with an occluding loop recognition element by click chemistry
    ACS Med Chem Lett (2016) 7, 211-216. PubMed  Europe PubMed DOI  PMC  EPMC  I
    47. 2015
  47. Hook,G., Jacobsen,J.S., Grabstein,K., Kindy,M. and Hook,V.
    Cathepsin B is a new drug target for traumatic brain injury therapeutics: evidence for E64d as a promising lead drug candidate
    Front Neurol (2015) 6, 178-178. PubMed  Europe PubMed DOI  PMC  EPMC  I
  48. Kedzior,M., Seredynski,R., Godzik,U., Tomczyk,D., Gutowicz,J., Terlecka,E., Calkosinski,I. and Terlecki,G.
    Inhibition of cathepsin B activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin
    Environ Sci Pollut Res Int (2015) 22, 733-737. PubMed  Europe PubMed DOI  I
  49. Kim,S.H., Zhao,M.H., Liang,S., Cui,X.S. and Kim,N.H.
    Inhibition of cathepsin B activity reduces apoptosis by preventing cytochrome c release from mitochondria in porcine parthenotes
    J Reprod Dev (2015) 61, 261-268. PubMed  Europe PubMed DOI  I
  50. Ramalho,S.D., De Sousa,L.R., Burger,M.C., Lima,M.I., da Silva,M.F., Fernandes,J.B. and Vieira,P.C.
    Evaluation of flavonols and derivatives as human cathepsin B inhibitor
    Nat Prod Res (2015) 29, 2212-2214. PubMed  Europe PubMed DOI  I
  51. Sbongile,M. and Soliman,M.E.
    In silico identification of irreversible cathepsin B inhibitors as anti-cancer agents: virtual screening, covalent docking analysis and molecular dynamics simulations
    Comb Chem High Throughput Screen (2015) 18, 399-410. PubMed  Europe PubMed  I
  52. Singh,M. and Raghav,N.
    2,3-Dihydroquinazolin-4(1H)-one derivatives as potential non-peptidyl inhibitors of cathepsins B and H
    Bioorg Chem (2015) 59C, 12-22. PubMed  Europe PubMed DOI  I
    53. 2014
  53. Edem,P.E., Czorny,S. and Valliant,J.F.
    Synthesis and evaluation of radioiodinated acyloxymethyl ketones as activity-based probes for cathepsin B
    J Med Chem (2014) 57, 9564-9577. PubMed  Europe PubMed DOI  I
  54. Hook,G., Yu,J., Toneff,T., Kindy,M. and Hook,V.
    Brain pyroglutamate amyloid-beta is produced by cathepsin B and is reduced by the cysteine protease inhibitor E64d, representing a potential Alzheimer's disease therapeutic
    J Alzheimers Dis (2014) 41, 129-149. PubMed  Europe PubMed DOI  I
  55. Hook,G.R., Yu,J., Sipes,N., Pierschbacher,M.D., Hook,V. and Kindy,M.S.
    The cysteine protease cathepsin B is a key drug target and cysteine protease inhibitors are potential therapeutics for traumatic brain injury
    J Neurotrauma (2014) 31, 515-529. PubMed  Europe PubMed DOI  T  I
  56. Kos,J., Mitrovic,A. and Mirkovic,B.
    The current stage of cathepsin B inhibitors as potential anticancer agents
    Future Med Chem (2014) 6, 1355-1371. PubMed  Europe PubMed DOI  I
  57. Mikhaylov,G., Klimpel,D., Schaschke,N., Mikac,U., Vizovisek,M., Fonovic,M., Turk,V., Turk,B. and Vasiljeva,O.
    Selective targeting of tumor and stromal cells by a nanocarrier system displaying lipidated cathepsin B inhibitor
    Angew Chem Int Ed Engl (2014) 53, 10077-10081. PubMed  Europe PubMed DOI  I
  58. Raghav,N. and Kaur,R.
    Synthesis and evaluation of some semicarbazone- and thiosemicarbazone-based cathepsin B inhibitors
    Med Chem Res (2014) 23, 4669-4679. DOI  I
  59. Raghav,N. and Singh,M.
    Design, synthesis and docking studies of bischalcones based quinazoline-2(1H)-ones and quinazoline-2(1H)-thiones derivatives as novel inhibitors of cathepsin B and cathepsin H
    Eur J Pharm Sci (2014) 54, 28-39. PubMed  Europe PubMed DOI  I
  60. Raghav,N. and Singh,M.
    Acyl hydrazides and triazoles as novel inhibitors of mammalian cathepsin B and cathepsin H
    Eur J Med Chem (2014) 77, 231-242. PubMed  Europe PubMed DOI  I
  61. Raghav,N. and Garg,S.
    SAR studies of o-hydroxychalcones and their cyclized analogs and study them as novel inhibitors of cathepsin B and cathepsin H
    Eur J Pharm Sci (2014) 60, 55-63. PubMed  Europe PubMed DOI  I
  62. Raghav,N. and Singh,M.
    SAR studies of differently functionalized chalcones based hydrazones and their cyclized derivatives as inhibitors of mammalian cathepsin B and cathepsin H
    Bioorg Med Chem (2014) 22, 4233-4245. PubMed  Europe PubMed DOI  I
  63. Ravish,I. and Raghav,N.
    Curcumin as inhibitor of mammalian cathepsin B, cathepsin H, acid phosphatase and alkaline phosphatase: a correlation with pharmacological activities
    Med Chem Res (2014) 23, 2847-2855. DOI  I
  64. Tong,B., Wan,B., Wei,Z., Wang,T., Zhao,P., Dou,Y., Lv,Z., Xia,Y. and Dai,Y.
    Role of cathepsin B in regulating migration and invasion of fibroblast-like synoviocytes into inflamed tissue from patients with rheumatoid arthritis
    Clin Exp Immunol (2014) 177, 586-597. PubMed  Europe PubMed DOI  I
  65. Vega-Teijido,M.A., El Chamy Maluf,S., Bonturi,C.R., Sambrano,J.R. and Ventura,O.N.
    Theoretical insight into the mechanism for the inhibition of the cysteine protease cathepsin B by 1,2,4-thiadiazole derivatives
    J Mol Model (2014) 20, 2254-2254. PubMed  Europe PubMed DOI  I
    66. 2013
  66. Baek,K.H., Karki,R., Lee,E.S., Na,Y. and Kwon,Y.
    Synthesis and investigation of dihydroxychalcones as calpain and cathepsin inhibitors
    Bioorg Chem (2013) 51, 24-30. PubMed  Europe PubMed DOI  I
  67. Balboula,A.Z., Yamanaka,K., Sakatani,M., Kawahara,M., Hegab,A.O., Zaabel,S.M. and Takahashi,M.
    Cathepsin B activity has a crucial role in the developmental competence of bovine cumulus-oocyte complexes exposed to heat shock during in vitro maturation
    Reproduction (2013) 146, 407-417. PubMed  Europe PubMed DOI  I
  68. Sosic,I., Mirkovic,B., Arenz,K., Stefane,B., Kos,J. and Gobec,S.
    Development of new cathepsin B inhibitors: combining bioisosteric replacements and structure-based design to explore the structure-activity relationships of nitroxoline derivatives
    J Med Chem (2013) 56, 521-533. PubMed  Europe PubMed DOI  I
    69. 2012
  69. Ha,S.D., Park,S., Hattlmann,C.J., Barr,S.D. and Kim,S.O.
    Inhibition or deficiency of cathepsin B leads defects in HIV-1 Gag pseudoparticle release in macrophages and HEK293T cells
    Antiviral Res (2012) 93, 175-184. PubMed  Europe PubMed DOI  I
  70. Withana,N.P., Blum,G., Sameni,M., Slaney,C., Anbalagan,A., Olive,M.B., Bidwell,B.N., Edgington,L., Wang,L., Moin,K., Sloane,B.F., Anderson,R.L., Bogyo,M.S. and Parker,B.S.
    Cathepsin B inhibition limits bone metastasis in breast cancer
    Cancer Res (2012) 72, 1199-1209. PubMed  Europe PubMed DOI  I
    71. 2011
  71. Asai,M., Yagishita,S., Iwata,N., Saido,T.C., Ishiura,S. and Maruyama,K.
    An alternative metabolic pathway of amyloid precursor protein C-terminal fragments via cathepsin B in a human neuroglioma model
    FASEB J (2011) 25, 3720-3730. PubMed  Europe PubMed DOI  I
  72. Fustero,S., Rodrigo,V., Sanchez-Rosello,M., Del Pozo,C., Timoneda,J., Frizler,M., Sisay,M.T., Bajorath,J., Calle,L.P., Canada,F.J., Jimenez-Barbero,J. and Gutschow,M.
    New cathepsin inhibitors to explore the fluorophilic properties of the S2 pocket of cathepsin B: design, synthesis, and biological evaluation
    Chemistry (2011) 17, 5256-5260. PubMed  Europe PubMed DOI  I
  73. Mirkovic,B., Renko,M., Turk,S., Sosic,I., Jevnikar,Z., Obermajer,N., Turk,D., Gobec,S. and Kos,J.
    Novel mechanism of cathepsin B inhibition by antibiotic nitroxoline and related compounds
    ChemMedChem (2011) 6, 1351-1356. PubMed  Europe PubMed DOI  I
  74. Murayama,S., Imae,Y., Takada,K., Kikuchi,J., Nakao,Y., Van Soest,R.W., Okada,S. and Matsunaga,S.
    Shishicrellastatins, inhibitors of cathepsin B, from the marine sponge Crella (Yvesia) spinulata
    Bioorg Med Chem (2011) 19, 6594-6598. PubMed  Europe PubMed DOI  I
  75. Sosic,I., Mirkovic,B., Turk,S., Stefane,B., Kos,J. and Gobec,S.
    Discovery and kinetic evaluation of 6-substituted 4-benzylthio-1,3,5-triazin-2(1H)-ones as inhibitors of cathepsin B
    Eur J Med Chem (2011) 46, 4648-4656. PubMed  Europe PubMed DOI  I
  76. Victor,B.C., Anbalagan,A., Mostafa Mohamed,M., Sloane,B.F. and Cavallo-Medved,D.
    Inhibition of cathepsin B activity attenuates extracellular matrix degradation and inflammatory breast cancer invasion
    Breast Cancer Res (2011) 13, R115-R115. PubMed  Europe PubMed DOI  I
  77. Wang,X., Liu,B., Tang,B. and Xiang,J.
    Potential role of cathepsin B in the embryonic and larval development of clam Meretrix meretrix
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