$VAR1 = undef;

Summary for peptidase S32.001: equine arteritis virus serine peptidase

Names
MEROPS Name	equine arteritis virus serine peptidase
Other names	3CLSP, nonstructural protein 4, nsp4 protease

Domain architecture

MEROPS Classification
Classification	Clan PA >> Subclan PA(S) >> Family S32 >> Subfamily (none) >> S32.001
Holotype	equine arteritis virus serine peptidase, Uniprot accession P19811 (peptidase unit: 1065-1261), MERNUM MER0000304
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Serine
Peplist	Included in the Peplist with identifier PL00400
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.114
Enzymology	BRENDA database
Proteolytic events	CutDB database (8 cleavages)
Physiology	Contributes to processing of viral polyprotein.
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	y/-/-/EGs/-/-/a (based on 15 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	1	1	0	1	10	1	0	0
Pro	0	0	1	0	0	0	0	1
Ala	0	1	1	0	0	1	1	4
Val	0	4	0	0	0	1	3	0
Leu	0	0	3	0	0	4	3	0
Ile	1	0	0	0	0	1	0	1
Met	3	0	0	0	0	0	0	0
Phe	1	3	1	0	0	0	1	0
Tyr	4	0	2	0	0	0	0	0
Trp	1	0	0	0	0	0	0	0
Ser	3	1	1	0	4	2	0	2
Thr	0	2	0	0	0	1	2	0
Cys	0	0	0	0	0	0	0	2
Asn	0	1	0	0	0	2	0	0
Gln	0	1	2	1	0	0	0	1
Asp	0	0	0	0	0	0	2	0
Glu	0	1	1	13	0	0	0	0
Lys	1	0	1	0	1	1	2	1
Arg	0	0	1	0	0	0	1	3
His	0	0	1	0	0	1	0	0