$VAR1 = undef;

Summary for peptidase S08.075: PCSK6 peptidase

Names
MEROPS Name	PCSK6 peptidase
Other names	proprotein convertase PACE4, PACE4 proprotein convertase, PCSK6 g.p. (Homo sapiens), proprotein convertase 6, proprotein convertase subtilisin/kexin type 6

Domain architecture

MEROPS Classification
Classification	Clan SB >> Subclan (none) >> Family S8 >> Subfamily B >> S08.075
Holotype	PCSK6 peptidase (Homo sapiens), Uniprot accession P29122 (peptidase unit: 182-473), MERNUM MER0000383
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Serine
Peplist	Included in the Peplist with identifier PL00362
NC-IUBMB	Not yet included in IUBMB recommendations.
Proteolytic events	CutDB database (7 cleavages)
Activity status	human: active (Mains, 2004) mouse: active (by similarity to human)
Physiology	Processes various preproteins by cleavage at paired basic amino acids.
Other databases	TREEFAM	http://www.treefam.org/family/TF314277
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	R/-/KR/Rs/val/-/- (based on 105 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	1	4	0	0	3	4	15	8
Pro	0	0	6	0	2	4	2	11
Ala	0	6	3	0	10	20	4	5
Val	4	7	1	0	3	29	2	6
Leu	0	4	1	0	1	15	8	12
Ile	2	0	0	0	0	8	4	1
Met	0	2	0	0	1	0	0	2
Phe	1	3	0	0	7	1	2	1
Tyr	1	0	0	0	6	0	1	0
Trp	0	0	0	0	0	1	0	0
Ser	0	12	2	0	33	4	14	10
Thr	0	7	2	0	1	10	7	6
Cys	0	0	0	0	3	0	0	1
Asn	0	5	0	0	1	0	5	4
Gln	1	10	0	0	7	0	4	3
Asp	0	2	0	0	9	4	13	10
Glu	1	3	1	0	9	0	11	13
Lys	7	19	53	3	0	2	5	3
Arg	85	12	36	102	1	0	3	3
His	2	7	0	0	5	0	2	3