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Literature for peptidase S08.075: PCSK6 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates Pharma

(Topics flags: S Structure, A Assay, T Target, P Specificity, K Knockout, V Review, M Mutation, I Inhibitor. To select only the references relevant to a single topic, click the link above. See explanation.)

    2023
  1. Mei,X., Zhou,H., Song,Z., Yang,X., Liu,X., Fei,J., Shen,Y. and Wang,X.<br>PCSK6 mediates Th1 differentiation and promotes chronic colitis progression and mucosal barrier injury via STAT1<br>Aging (Albany NY) (2023) 15, 4363-4373. PubMed  Europe PubMed DOI  PMC  EPMC  K
  2. Mohammad,A.H., Couture,F., Gamache,I., Chen,O., El-Assaad,W., Abdel-Malak,N., Kwiatkowska,A., Muller,W., Day,R. and Teodoro,J.G.<br>Cleavage of the V-ATPase associated prorenin receptor is mediated by PACE4 and is essential for growth of prostate cancer cells<br>PLoS ONE (2023) 18, e0288622-e0288622. PubMed  Europe PubMed DOI  PMC  EPMC
    3. 2022
  3. Couture,F., Wang,L., Dufour,F., Chabot-Maheux,K., Ekindi Ndongo,N., Sabbagh,R. and Day,R.<br>PACE4-altCT isoform of proprotein convertase PACE4 as tissue and plasmatic biomarker for prostate cancer<br>Sci Rep (2022) 12, 6066-6066. PubMed  Europe PubMed DOI  PMC  EPMC
  4. Dobo,J., Kocsis,A., Dani,R. and Gal,P.<br>Proprotein Convertases and the Complement System<br>Front Immunol (2022) 13, 958121-958121. PubMed  Europe PubMed DOI  PMC  EPMC  V
  5. Wu,Q. and Chen,S.<br>Proprotein Convertase Subtilisin/Kexin 6 in Cardiovascular Biology and Disease<br>Int J Mol Sci (2022) 23 PubMed  Europe PubMed DOI  PMC  EPMC  V
    6. 2021
  6. Testa,G., Staurenghi,E., Giannelli,S., Sottero,B., Gargiulo,S., Poli,G., Gamba,P. and Leonarduzzi,G.<br>Up-regulation of PCSK6 by lipid oxidation products: A possible role in atherosclerosis<br>Biochimie (2021) 181, 191-203. PubMed  Europe PubMed DOI  I
    7. 2020
  7. Rykaczewska,U., Suur,B.E., Rohl,S., Razuvaev,A., Lengquist,M., Sabater-Lleal,M., van der Laan,S.W., Miller,C.L., Wirka,R.C., Kronqvist,M., Gonzalez Diez,M., Vesterlund,M., Gillgren,P., Odeberg,J., Lindeman,J.H., Veglia,F., Humphries,S.E., de Faire,U., Baldassarre,D., Tremoli,E., Lehtio,J., Hansson,G.K., Paulsson-Berne,G., Pasterkamp,G., Quertermous,T., Hamsten,A., Eriksson,P., Hedin,U. and Matic,L.<br>PCSK6 is a key protease in the control of smooth muscle cell function in vascular remodeling<br>Circ Res (2020) 126, 571-585. PubMed  Europe PubMed DOI  M
    8. 2018
  8. Dianati,V., Kwiatkowska,A., Couture,F., Desjardins,R., Dory,Y.L. and Day,R.<br>Increasing C-terminal hydrophobicity improves the cell permeability and antiproliferative activity of PACE4 inhibitors against prostate cancer cell lines<br>J Med Chem (2018) 61, 8457-8467. PubMed  Europe PubMed DOI  I
  9. Dianati,V., Navals,P., Couture,F., Desjardins,R., Dame,A., Kwiatkowska,A., Day,R. and Dory,Y.L.<br>Improving the selectivity of PACE4 inhibitors through modifications of the P1 residue<br>J Med Chem (2018) 61, 11250-11260. PubMed  Europe PubMed DOI  I
  10. Li,J.J., Liu,J., Lupino,K., Liu,X., Zhang,L. and Pei,L.<br>Growth Differentiation Factor 15 maturation requires proteolytic cleavage by PCSK3, 5 and 6<br>Mol Cell Biol (2018) 38, e00249-18-e00249-18. PubMed  Europe PubMed DOI
    11. 2017
  11. Chen,S., Wang,H., Li,H., Zhang,Y. and Wu,Q.<br>Functional analysis of corin protein domains required for PCSK6-mediated activation<br>Int J Biochem Cell Biol (2017) 94, 31-39. PubMed  Europe PubMed DOI
  12. Dianati,V., Shamloo,A., Kwiatkowska,A., Desjardins,R., Soldera,A., Day,R. and Dory,Y.L.<br>Rational design of a highly potent and selective peptide inhibitor of PACE4 by salt bridge interaction with D160 at position P3<br>ChemMedChem (2017) 12, 1169-1172. PubMed  Europe PubMed DOI  I
  13. Maluch,I., Levesque,C., Kwiatkowska,A., Couture,F., Ly,K., Desjardins,R., Neugebauer,W.A., Prahl,A. and Day,R.<br>Positional scanning identifies the molecular determinants of a high affinity multi-leucine inhibitor for furin and PACE4<br>J Med Chem (2017) 60, 2732-2744. PubMed  Europe PubMed DOI  I
  14. Okada,K., Moon,H.J., Finney,J., Couture,F., Day,R. and Mure,M.<br>PACE4 Proteolytically processes LOXL2 with little impact on its catalytic activity<br>J Biol Chem (2017) PubMed  Europe PubMed DOI
  15. Panet,F., Couture,F., Kwiatkowska,A., Desjardins,R., Guerin,B. and Day,R.<br>PACE4 is an important driver of ZR-75-1 estrogen receptor-positive breast cancer proliferation and tumor progression<br>Eur J Cell Biol (2017) 96, 469-475. PubMed  Europe PubMed DOI  I
    16. 2016
  16. Demasi,M.A., de S Molina,E., Bowman-Colin,C., Lojudice,F.H., Muras,A. and Sogayar,M.C.<br>Enhanced proteolytic processing of recombinant human coagulation factor VIII B-domain variants by recombinant furins<br>Mol Biotechnol (2016) 58, 404-414. PubMed  Europe PubMed DOI
  17. Maluch,I., Walewska,A., Sikorska,E. and Prahl,A.<br>[Proprotein convertases - family of serine proteases with a broad spectrum of physiological functions]<br>Postepy Biochem (2016) 62, 472-481. PubMed  Europe PubMed  V
  18. Volpe,M. and Rubattu,S.<br>Novel insights into the mechanisms regulating pro-atrial natriuretic peptide cleavage in the heart and blood pressure regulation: proprotein convertase subtilisin/kexin 6 is the corin activating enzyme<br>Circ Res (2016) 118, 196-198. PubMed  Europe PubMed DOI
    19. 2015
  19. Bessonnard,S., Mesnard,D. and Constam,D.B.<br>PC7 and the related proteases furin and pace4 regulate E-cadherin function during blastocyst formation<br>J Cell Biol (2015) 210, 1185-1197. PubMed  Europe PubMed DOI  PMC  EPMC
  20. Chen,S., Cao,P., Dong,N., Peng,J., Zhang,C., Wang,H., Zhou,T., Yang,J., Zhang,Y., Martelli,E.E., Naga Prasad,S.V., Miller,R.E., Malfait,A.M., Zhou,Y. and Wu,Q.<br>PCSK6-mediated corin activation is essential for normal blood pressure<br>Nat Med (2015) 21, 1048-1053. PubMed  Europe PubMed DOI
  21. Guillemot,J. and Seidah,N.G.<br>PACE4 (PCSK6): another proprotein convertase link to iron homeostasis?<br>Haematologica (2015) 100, e377-e377. PubMed  Europe PubMed DOI  I
  22. Kara,I., Poggi,M., Bonardo,B., Govers,R., Landrier,J.F., Tian,S., Leibiger,I., Day,R., Creemers,J.W. and Peiretti,F.<br>The paired basic amino acid-cleaving enzyme 4 (PACE4) is involved in the maturation of insulin receptor isoform B: an opportunity to reduce the specific insulin receptor-dependent effects of insulin-like growth factor 2 (IGF2)<br>J Biol Chem (2015) 290, 2812-2821. PubMed  Europe PubMed DOI
  23. Kim,H., Tabata,A., Tomoyasu,T., Ueno,T., Uchiyama,S., Yuasa,K., Tsuji,A. and Nagamune,H.<br>Estrogen stimuli promote osteoblastic differentiation via the subtilisin-like proprotein convertase PACE4 in MC3T3-E1 cells<br>J Bone Miner Metab (2015) 33, 30-39. PubMed  Europe PubMed DOI
  24. Layne,J.D., Shridas,P. and Webb,N.R.<br>Ectopically expressed pro-group X secretory phospholipase A2 is proteolytically activated in mouse adrenal cells by furin-like proprotein convertases: implications for the regulation of adrenal steroidogenesis<br>J Biol Chem (2015) 290, 7851-7860. PubMed  Europe PubMed DOI
  25. Pagani,A., Ladli,M., Nai,A., Verdier,F., Camaschella,C. and Silvestri,L.<br>Comment on: PACE4 (PCSK6): another proprotein convertase linked to iron homeostasis?<br>Haematologica (2015) 100, e380-e380. PubMed  Europe PubMed DOI
  26. Pang,X., Pan,J., Gao,P., Wang,Y., Wang,L., Du,B. and Wei,Q.<br>A visible light induced photoelectrochemical aptsensor constructed by aligned ZnO@CdTe core shell nanocable arrays/carboxylated g-C3N4 for the detection of proprotein convertase subtilisin/kexin type 6 gene<br>Biosens Bioelectron (2015) 74, 49-58. PubMed  Europe PubMed DOI  A
  27. Wang,F., Wang,L., Jiang,H., Chang,X. and Pan,J.<br>Inhibition of PCSK6 may play a protective role in the development of rheumatoid arthritis<br>J Rheumatol (2015) 42, 161-169. PubMed  Europe PubMed DOI  M
    28. 2013
  28. Perisic,L., Hedin,E., Razuvaev,A., Lengquist,M., Osterholm,C., Folkersen,L., Gillgren,P., Paulsson-Berne,G., Ponten,F., Odeberg,J. and Hedin,U.<br>Profiling of atherosclerotic lesions by gene and tissue microarrays reveals PCSK6 as a novel protease in unstable carotid atherosclerosis<br>Arterioscler Thromb Vasc Biol (2013) 33, 2432-2443. PubMed  Europe PubMed DOI
  29. Seidah,N.G., Sadr,M.S., Chretien,M. and Mbikay,M.<br>The multifaceted proprotein convertases: their unique, redundant, complementary, and opposite functions<br>J Biol Chem (2013) 288, 21473-21481. PubMed  Europe PubMed DOI  V
  30. Turpeinen,H., Ortutay,Z. and Pesu,M.<br>Genetics of the first seven proprotein convertase enzymes in health and disease<br>Curr Genomics (2013) 14, 453-467. PubMed  Europe PubMed DOI  PMC  EPMC  V
    31. 2012
  31. Akamatsu,T.<br>Proprotein convertase PACE4<br>[ISSN:978-0-12-407742-3] (2012) 3, 3299-3305. DOI
  32. Levesque,C., Fugere,M., Kwiatkowska,A., Couture,F., Desjardins,R., Routhier,S., Moussette,P., Prahl,A., Lammek,B., Appel,J.R., Houghten,R.A., D'Anjou,F., Dory,Y.L., Neugebauer,W. and Day,R.<br>The multi-Leu peptide inhibitor discriminates between PACE4 and furin and exhibits antiproliferative effects on prostate cancer cells<br>J Med Chem (2012) 55, 10501-10511. PubMed  Europe PubMed DOI  I
  33. Seidah,N.G. and Prat,A.<br>The biology and therapeutic targeting of the proprotein convertases<br>Nat Rev Drug Discov (2012) 11, 367-383. PubMed  Europe PubMed DOI  V
  34. Yuasa,K., Futamatsu,G., Kawano,T., Muroshita,M., Kageyama,Y., Taichi,H., Ishikawa,H., Nagahama,M., Matsuda,Y. and Tsuji,A.<br>Subtilisin-like proprotein convertase paired basic amino acid-cleaving enzyme4 is required for chondrogenic differentiation in ATDC5 cells<br>FEBS J (2012) 279, 3997-4009. PubMed  Europe PubMed DOI
    35. 2011
  35. Basak,A., Chen,A., Majumdar,S. and Smith,H.P.<br>In vitro assay for protease activity of proprotein convertase subtilisin kexins (PCSKs): an overall review of existing and new methodologies<br>Methods Mol Biol (2011) 768, 127-153. PubMed  Europe PubMed DOI  A
  36. Mesnard,D., Donnison,M., Fuerer,C., Pfeffer,P.L. and Constam,D.B.<br>The microenvironment patterns the pluripotent mouse epiblast through paracrine furin and pace4 proteolytic activities<br>Genes Dev (2011) 25, 1871-1880. PubMed  Europe PubMed DOI
  37. Mujoomdar,M.L., Hogan,L.M., Parlow,A.F. and Nachtigal,M.W.<br>Pcsk6 mutant mice exhibit progressive loss of ovarian function, altered gene expression, and formation of ovarian pathology<br>Reproduction (2011) 141, 343-355. PubMed  Europe PubMed DOI  K  M
  38. Scerri,T.S., Brandler,W.M., Paracchini,S., Morris,A.P., Ring,S.M., Richardson,A.J., Talcott,J.B., Stein,J. and Monaco,A.P.<br>PCSK6 is associated with handedness in individuals with dyslexia<br>Hum Mol Genet (2011) 20, 608-614. PubMed  Europe PubMed DOI
  39. Seidah,N.G.<br>What lies ahead for the proprotein convertases?<br>Ann N Y Acad Sci (2011) 1220, 149-161. PubMed  Europe PubMed DOI  V
  40. Seidah,N.G.<br>The proprotein convertases, 20 years later<br>Methods Mol Biol (2011) 768, 23-57. PubMed  Europe PubMed DOI  V
    41. 2010
  41. Akamatsu,T.<br>Physiological role of a subtilisin-like proprotein convertase, PACE4, in submandibular gland development<br>J Oral Biosci (2010) 52, 81-93. DOI
  42. Bassi,D.E., Zhang,J., Cenna,J., Litwin,S., Cukierman,E. and Klein-Szanto,A.J.<br>Proprotein convertase inhibition results in decreased skin cell proliferation, tumorigenesis, and metastasis<br>Neoplasia (2010) 12, 516-526. PubMed  Europe PubMed DOI  PMC  EPMC  I
  43. Tian,S. and Jianhua,W.<br>Comparative study of the binding pockets of mammalian proprotein convertases and its implications for the design of specific small molecule inhibitors<br>Int J Biol Sci (2010) 6, 89-95. PubMed  Europe PubMed  PMC  EPMC  P  I
    44. 2009
  44. Akamatsu,T., Azlina,A., Javkhlan,P., Hasegawa,T., Yao,C. and Hosoi,K.<br>Salivary gland development: its mediation by a subtilisin-like proprotein convertase, PACE4<br>J Med Invest (2009) 56 Suppl, 241-246. PubMed  Europe PubMed DOI
  45. Rholam,M. and Fahy,C.<br>Processing of peptide and hormone precursors at the dibasic cleavage sites<br>Cell Mol Life Sci (2009) 66, 2075-2091. PubMed  Europe PubMed DOI
  46. Yuasa,K., Masuda,T., Yoshikawa,C., Nagahama,M., Matsuda,Y. and Tsuji,A.<br>Subtilisin-like proprotein convertase PACE4 is required for skeletal muscle differentiation<br>J Biochem (2009) 146, 407-415. PubMed  Europe PubMed DOI
    47. 2008
  47. Creemers,J.W. and Khatib,A.M.<br>Knock-out mouse models of proprotein convertases: unique functions or redundancy?<br>Front Biosci (2008) 13, 4960-4971. PubMed  Europe PubMed DOI  K
  48. Malfait,A.M., Arner,E.C., Song,R.H., Alston,J.T., Markosyan,S., Staten,N., Yang,Z., Griggs,D.W. and Tortorella,M.D.<br>Proprotein convertase activation of aggrecanases in cartilage in situ<br>Arch Biochem Biophys (2008) 478, 43-51. PubMed  Europe PubMed DOI  T
  49. Remacle,A.G., Shiryaev,S.A., Oh,E.S., Cieplak,P., Srinivasan,A., Wei,G., Liddington,R.C., Ratnikov,B.I., Parent,A., Desjardins,R., Day,R., Smith,J.W., Lebl,M. and Strongin,A.Y.<br>Substrate cleavage analysis of furin and related proprotein convertases. A comparative study<br>J Biol Chem (2008) 283, 20897-20906. PubMed  Europe PubMed DOI  PMC  EPMC  P
    50. 2007
  50. Akamatsu,T., Purwanti,N., Karabasil,M.R., Li,X., Yao,C., Kanamori,N. and Hosoi,K.<br>Temporospatially regulated expression of subtilisin-like proprotein convertase PACE4 (SPC4) during development of the rat submandibular gland<br>Dev Dyn (2007) 236, 314-320. PubMed  Europe PubMed DOI
  51. Hall,T., Fok,K.F., Liu,M.M., Zobel,J.F., Marino,M.H., Malfait,A.M., Tortorella,M.D. and Tomasselli,A.G.<br>A high performance liquid chromatography assay for monitoring proprotein convertase activity<br>J Chromatogr A (2007) 1148, 46-54. PubMed  Europe PubMed DOI  A
  52. Tsuji,A., Kanie,H., Makise,H., Yuasa,K., Nagahama,M. and Matsuda,Y.<br>Engineering of alpha1-antitrypsin variants selective for subtilisin-like proprotein convertases PACE4 and PC6: importance of the P2' residue in stable complex formation of the serpin with proprotein convertase<br>Protein Eng Des Sel (2007) 20, 163-170. PubMed  Europe PubMed DOI
  53. Yuasa,K., Suzue,K., Nagahama,M., Matsuda,Y. and Tsuji,A.<br>Transcriptional regulation of subtilisin-like proprotein convertase PACE4 by E2F: possible role of E2F-mediated upregulation of PACE4 in tumor progression<br>Gene (2007) 402, 103-110. PubMed  Europe PubMed DOI
    54. 2006
  54. Scamuffa,N., Calvo,F., Chretien,M., Seidah,N.G. and Khatib,A.M.<br>Proprotein convertases: lessons from knockouts<br>FASEB J (2006) 20, 1954-1963. PubMed  Europe PubMed DOI  K  V
    55. 2005
  55. Birsoy,B., Berg,L., Williams,P.H., Smith,J.C., Wylie,C.C., Christian,J.L. and Heasman,J.<br>XPACE4 is a localized pro-protein convertase required for mesoderm induction and the cleavage of specific TGFbeta proteins in Xenopus development<br>Development (2005) 132, 591-602. PubMed  Europe PubMed DOI
  56. [YEAR:14-1-2005]Henrich,S., Lindberg,I., Bode,W. and Than,M.E.<br>Proprotein convertase models based on the crystal structures of furin and kexin: explanation of their specificity<br>J Mol Biol (14-1-2005) 345, 211-227. PubMed  Europe PubMed DOI  S
  57. Nour,N., Mayer,G., Mort,J.S., Salvas,A., Mbikay,M., Morrison,C.J., Overall,C.M. and Seidah,N.G.<br>The cysteine-rich domain of the secreted proprotein convertases PC5A and PACE4 functions as a cell surface anchor and interacts with tissue inhibitors of metalloproteinases<br>Mol Biol Cell (2005) 16, 5215-5226. PubMed  Europe PubMed DOI  PMC  EPMC
    58. 2004
  58. Mains,R.E.<br>Proprotein convertase PACE4<br>[ISSN:0-12-079610-4] (2004) 2, 1871-1874.  V
    59. 2003
  59. Fu,Y., Campbell,E.J., Shepherd,T.G. and Nachtigal,M.W.<br>Epigenetic regulation of proprotein convertase PACE4 gene expression in human ovarian cancer cells<br>Mol Cancer Res (2003) 1, 569-576. PubMed  Europe PubMed
  60. Siegfried,G., Basak,A., Cromlish,J.A., Benjannet,S., Marcinkiewicz,J., Chretien,M., Seidah,N.G. and Khatib,A.M.<br>The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis<br>J Clin Invest (2003) 111, 1723-1732. PubMed  Europe PubMed DOI  PMC  EPMC
  61. Taylor,N.A., Van de Ven,W.J. and Creemers,J.W.<br>Curbing activation: proprotein convertases in homeostasis and pathology<br>FASEB J (2003) 17, 1215-1227. PubMed  Europe PubMed DOI  K
  62. [YEAR:31-1-2003]Tsuji,A., Sakurai,K., Kiyokage,E., Yamazaki,T., Koide,S., Toida,K., Ishimura,K. and Matsuda,Y.<br>Secretory proprotein convertases PACE4 and PC6A are heparin-binding proteins which are localized in the extracellular matrix. Potential role of PACE4 in the activation of proproteins in the extracellular matrix<br>Biochim Biophys Acta (31-1-2003) 1645, 95-104. PubMed  Europe PubMed DOI
    63. 2002
  63. Beck,S., Le Good,J.A., Guzman,M., Ben Haim,N., Roy,K., Beermann,F. and Constam,D.B.<br>Extraembryonic proteases regulate Nodal signalling during gastrulation<br>Nat Cell Biol (2002) 4, 981-985. PubMed  Europe PubMed DOI
  64. Fugere,M. and Day,R.<br>Inhibitors of the subtilase-like pro-protein convertases (SPCs)<br>Curr Pharm Des (2002) 8, 549-562. PubMed  Europe PubMed DOI  V  I
  65. Seidah,N.G. and Prat,A.<br>Precursor convertases in the secretory pathway, cytosol and extracellular milieu<br>Essays Biochem (2002) 38, 79-94. PubMed  Europe PubMed
  66. [YEAR:18-1-2002]Taniguchi,T., Kuroda,R., Sakurai,K., Nagahama,M., Wada,I., Tsuji,A. and Matsuda,Y.<br>A critical role for the carboxy terminal region of the proprotein convertase, PACE4A, in the regulation of its autocatalytic activation coupled with secretion<br>Biochem Biophys Res Commun (18-1-2002) 290, 878-884. PubMed  Europe PubMed DOI
    67. 2001
  67. [YEAR:15-12-2001]Yoshida,I., Koide,S., Hasegawa,S.I., Nakagawara,A., Tsuji,A. and Matsuda,Y.<br>Proprotein convertase PACE4 is down-regulated by the basic helix-loop-helix transcription factor hASH-1 and MASH-1<br>Biochem J (15-12-2001) 360, 683-689. PubMed  Europe PubMed DOI  PMC  EPMC
    68. 2000
  68. [YEAR:7-6-2000]Akamatsu,T., Matsuda,Y., Tsumura,K., Tada,J., Parvin,M.N., Wei,W., Kanamori,N. and Hosoi,K.<br>Highly regulated expression of subtilisin-like proprotein convertase PACE4 (SPC4) during dentinogenesis<br>Biochem Biophys Res Commun (7-6-2000) 272, 410-415. PubMed  Europe PubMed DOI
  69. Bassi,D.E., Mahloogi,H. and Klein-Szanto,A.J.<br>The proprotein convertases furin and PACE4 play a significant role in tumor progression<br>Mol Carcinog (2000) 28, 63-69. PubMed  Europe PubMed DOI
    70. 1999
  70. [YEAR:1-5-1999]Sucic,J.F., Moehring,J.M., Inocencio,N.M., Luchini,J.W. and Moehring,T.J.<br>Endoprotease PACE4 is Ca2+-dependent and temperature-sensitive and can partly rescue the phenotype of a furin-deficient cell strain<br>Biochem J (1-5-1999) 339, 639-647. PubMed  Europe PubMed  PMC  EPMC
  71. Tsuji,A., Hashimoto,E., Ikoma,T., Taniguchi,T., Mori,K., Nagahama,M. and Matsuda,Y.<br>Inactivation of proprotein convertase, PACE4, by alpha1-antitrypsin Portland (alpha1-PDX), a blocker of proteolytic activation of bone morphogenetic protein during embryogenesis: evidence that PACE4 is able to form an SDS-stable acyl intermediate with alpha1-PDX<br>J Biochem (1999) 126, 591-603. PubMed  Europe PubMed  I
    72. 1997
  72. Gordon,V.M., Rehemtulla,A. and Leppla,S.H.<br>A role for PACE4 in the proteolytic activation of anthrax toxin protective antigen<br>Infect Immun (1997) 65, 3370-3375. PubMed  Europe PubMed  PMC  EPMC
  73. [YEAR:1-12-1997]Hubbard,F.C., Goodrow,T.L., Liu,S.C., Brilliant,M.H., Basset,P., Mains,R.E. and Klein-Szanto,A.J.<br>Expression of PACE4 in chemically induced carcinomas is associated with spindle cell tumor conversion and increased invasive ability<br>Cancer Res (1-12-1997) 57, 5226-5231. PubMed  Europe PubMed
  74. Mains,R.E., Berard,C.A., Denault,J.B., Zhou,A., Johnson,R.C. and Leduc,R.<br>PACE4: a subtilisin-like endoprotease with unique properties<br>Biochem J (1997) 321, 587-593. PubMed  Europe PubMed  PMC  EPMC  I
  75. Mori,K., Kii,S., Tsuji,A., Nagahama,M., Imamaki,A., Hayashi,K., Akamatsu,T., Nagamune,H. and Matsuda,Y.<br>A novel human PACE4 isoform, PACE4E is an active processing protease containing a hydrophobic cluster at the carboxy terminus<br>J Biochem (1997) 121, 941-948. PubMed  Europe PubMed
  76. Tsuji,A., Hine,C., Tamai,Y., Yonemoto,K., Mori,K., Yoshida,S., Bando,M., Sakai,E., Mori,K., Akamatsu,T. and Matsuda,Y.<br>Genomic organization and alternative splicing of human PACE4 (SPC4), kexin-like processing endoprotease<br>J Biochem (1997) 122, 438-452. PubMed  Europe PubMed
    77. 1996
  77. Constam,D.B., Calfon,M. and Robertson,E.J.<br>SPC4, SPC6, and the novel protease SPC7 are coexpressed with bone morphogenetic proteins at distinct sites during embryogenesis<br>J Cell Biol (1996) 134, 181-191. PubMed  Europe PubMed DOI  PMC  EPMC
  78. Zhong,M., Benjannet,S., Lazure,C., Munzer,S. and Seidah,N.G.<br>Functional analysis of human PACE4-A and PACE4-C isoforms: identification of a new PACE4-CS isoform<br>FEBS Lett (1996) 396, 31-36. PubMed  Europe PubMed DOI
    79. 1995
  79. Brakch,N., Galanopoulou,A.S., Patel,Y.C., Boileau,G. and Seidah,N.G.<br>Comparative proteolytic processing of rat prosomatostatin by the convertases PC1, PC2, furin, PACE4 and PC5 in constitutive and regulated secretory pathways<br>FEBS Lett (1995) 362, 143-146. PubMed  Europe PubMed DOI
  80. Dong,W., Marcinkiewicz,M., Vieau,D., Chretien,M., Seidah,N.G. and Day,R.<br>Distinct mRNA expression of the highly homologous convertases PC5 and PACE4 in the rat brain and pituitary<br>J Neurosci (1995) 15, 1778-1796. PubMed  Europe PubMed
  81. Mbikay,M., Seidah,N.G., Chretien,M. and Simpson,E.M.<br>Chromosomal assignment of the genes for proprotein convertases PC4, PC5, and PACE 4 in mouse and human<br>Genomics (1995) 26, 123-129. PubMed  Europe PubMed DOI
  82. Nagamune,H., Muramatsu,K., Akamatsu,T., Tamai,Y., Izumi,K., Tsuji,A. and Matsuda,Y.<br>Distribution of the kexin family proteases in pancreatic islets: PACE4C is specifically expressed in B cells of pancreatic islets<br>Endocrinology (1995) 136, 357-360. PubMed  Europe PubMed DOI
    83. 1994
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