Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Literature for peptidase S08.075: PCSK6 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates Pharma

(Topics flags: S Structure, A Assay, T Target, P Specificity, K Knockout, V Review, M Mutation, I Inhibitor. To select only the references relevant to a single topic, click the link above. See explanation.)

    2023
  1. Mei,X., Zhou,H., Song,Z., Yang,X., Liu,X., Fei,J., Shen,Y. and Wang,X.
    PCSK6 mediates Th1 differentiation and promotes chronic colitis progression and mucosal barrier injury via STAT1
    Aging (Albany NY)15, 4363-4373. PubMed  Europe PubMed DOI  K
  2. Mohammad,A.H., Couture,F., Gamache,I., Chen,O., El-Assaad,W., Abdel-Malak,N., Kwiatkowska,A., Muller,W., Day,R. and Teodoro,J.G.
    Cleavage of the V-ATPase associated prorenin receptor is mediated by PACE4 and is essential for growth of prostate cancer cells
    PLoS ONE18, e0288622-e0288622. PubMed  Europe PubMed DOI
    3. 2022
  3. Couture,F., Wang,L., Dufour,F., Chabot-Maheux,K., Ekindi Ndongo,N., Sabbagh,R. and Day,R.
    PACE4-altCT isoform of proprotein convertase PACE4 as tissue and plasmatic biomarker for prostate cancer
    Sci Rep12, 6066-6066. PubMed  Europe PubMed DOI
  4. Dobo,J., Kocsis,A., Dani,R. and Gal,P.
    Proprotein Convertases and the Complement System
    Front Immunol13, 958121-958121. PubMed  Europe PubMed DOI  V
  5. Wu,Q. and Chen,S.
    Proprotein Convertase Subtilisin/Kexin 6 in Cardiovascular Biology and Disease
    Int J Mol Sci23, PubMed  Europe PubMed DOI  V
    6. 2021
  6. Testa,G., Staurenghi,E., Giannelli,S., Sottero,B., Gargiulo,S., Poli,G., Gamba,P. and Leonarduzzi,G.
    Up-regulation of PCSK6 by lipid oxidation products: A possible role in atherosclerosis
    Biochimie181, 191-203. PubMed  Europe PubMed DOI  I
    7. 2020
  7. Rykaczewska,U., Suur,B.E., Rohl,S., Razuvaev,A., Lengquist,M., Sabater-Lleal,M., van der Laan,S.W., Miller,C.L., Wirka,R.C., Kronqvist,M., Gonzalez Diez,M., Vesterlund,M., Gillgren,P., Odeberg,J., Lindeman,J.H., Veglia,F., Humphries,S.E., de Faire,U., Baldassarre,D., Tremoli,E., Lehtio,J., Hansson,G.K., Paulsson-Berne,G., Pasterkamp,G., Quertermous,T., Hamsten,A., Eriksson,P., Hedin,U. and Matic,L.
    PCSK6 is a key protease in the control of smooth muscle cell function in vascular remodeling
    Circ Res126, 571-585. PubMed  Europe PubMed DOI  M
    8. 2018
  8. Dianati,V., Navals,P., Couture,F., Desjardins,R., Dame,A., Kwiatkowska,A., Day,R. and Dory,Y.L.
    Improving the selectivity of PACE4 inhibitors through modifications of the P1 residue
    J Med Chem61, 11250-11260. PubMed  Europe PubMed DOI  I
  9. Dianati,V., Kwiatkowska,A., Couture,F., Desjardins,R., Dory,Y.L. and Day,R.
    Increasing C-terminal hydrophobicity improves the cell permeability and antiproliferative activity of PACE4 inhibitors against prostate cancer cell lines
    J Med Chem61, 8457-8467. PubMed  Europe PubMed DOI  I
  10. Li,J.J., Liu,J., Lupino,K., Liu,X., Zhang,L. and Pei,L.
    Growth Differentiation Factor 15 maturation requires proteolytic cleavage by PCSK3, 5 and 6
    Mol Cell Biol38, e00249-18-e00249-18. PubMed  Europe PubMed DOI
    11. 2017
  11. Chen,S., Wang,H., Li,H., Zhang,Y. and Wu,Q.
    Functional analysis of corin protein domains required for PCSK6-mediated activation
    Int J Biochem Cell Biol94, 31-39. PubMed  Europe PubMed DOI
  12. Dianati,V., Shamloo,A., Kwiatkowska,A., Desjardins,R., Soldera,A., Day,R. and Dory,Y.L.
    Rational design of a highly potent and selective peptide inhibitor of PACE4 by salt bridge interaction with D160 at position P3
    ChemMedChem12, 1169-1172. PubMed  Europe PubMed DOI  I
  13. Maluch,I., Levesque,C., Kwiatkowska,A., Couture,F., Ly,K., Desjardins,R., Neugebauer,W.A., Prahl,A. and Day,R.
    Positional scanning identifies the molecular determinants of a high affinity multi-leucine inhibitor for furin and PACE4
    J Med Chem60, 2732-2744. PubMed  Europe PubMed DOI  I
  14. Okada,K., Moon,H.J., Finney,J., Couture,F., Day,R. and Mure,M.
    PACE4 Proteolytically processes LOXL2 with little impact on its catalytic activity
    J Biol Chem PubMed  Europe PubMed DOI
  15. Panet,F., Couture,F., Kwiatkowska,A., Desjardins,R., Guerin,B. and Day,R.
    PACE4 is an important driver of ZR-75-1 estrogen receptor-positive breast cancer proliferation and tumor progression
    Eur J Cell Biol96, 469-475. PubMed  Europe PubMed DOI  I
    16. 2016
  16. Demasi,M.A., de S Molina,E., Bowman-Colin,C., Lojudice,F.H., Muras,A. and Sogayar,M.C.
    Enhanced proteolytic processing of recombinant human coagulation factor VIII B-domain variants by recombinant furins
    Mol Biotechnol58, 404-414. PubMed  Europe PubMed DOI
  17. Maluch,I., Walewska,A., Sikorska,E. and Prahl,A.
    [Proprotein convertases - family of serine proteases with a broad spectrum of physiological functions]
    Postepy Biochem62, 472-481. PubMed  Europe PubMed  V
  18. Volpe,M. and Rubattu,S.
    Novel insights into the mechanisms regulating pro-atrial natriuretic peptide cleavage in the heart and blood pressure regulation: proprotein convertase subtilisin/kexin 6 is the corin activating enzyme
    Circ Res118, 196-198. PubMed  Europe PubMed DOI
    19. 2015
  19. Bessonnard,S., Mesnard,D. and Constam,D.B.
    PC7 and the related proteases furin and pace4 regulate E-cadherin function during blastocyst formation
    J Cell Biol210, 1185-1197. PubMed  Europe PubMed DOI
  20. Chen,S., Cao,P., Dong,N., Peng,J., Zhang,C., Wang,H., Zhou,T., Yang,J., Zhang,Y., Martelli,E.E., Naga Prasad,S.V., Miller,R.E., Malfait,A.M., Zhou,Y. and Wu,Q.
    PCSK6-mediated corin activation is essential for normal blood pressure
    Nat Med21, 1048-1053. PubMed  Europe PubMed DOI
  21. Guillemot,J. and Seidah,N.G.
    PACE4 (PCSK6): another proprotein convertase link to iron homeostasis?
    Haematologica100, e377-e377. PubMed  Europe PubMed DOI  I
  22. Kara,I., Poggi,M., Bonardo,B., Govers,R., Landrier,J.F., Tian,S., Leibiger,I., Day,R., Creemers,J.W. and Peiretti,F.
    The paired basic amino acid-cleaving enzyme 4 (PACE4) is involved in the maturation of insulin receptor isoform B: an opportunity to reduce the specific insulin receptor-dependent effects of insulin-like growth factor 2 (IGF2)
    J Biol Chem290, 2812-2821. PubMed  Europe PubMed DOI
  23. Kim,H., Tabata,A., Tomoyasu,T., Ueno,T., Uchiyama,S., Yuasa,K., Tsuji,A. and Nagamune,H.
    Estrogen stimuli promote osteoblastic differentiation via the subtilisin-like proprotein convertase PACE4 in MC3T3-E1 cells
    J Bone Miner Metab33, 30-39. PubMed  Europe PubMed DOI
  24. Layne,J.D., Shridas,P. and Webb,N.R.
    Ectopically expressed pro-group X secretory phospholipase A2 is proteolytically activated in mouse adrenal cells by furin-like proprotein convertases: implications for the regulation of adrenal steroidogenesis
    J Biol Chem290, 7851-7860. PubMed  Europe PubMed DOI
  25. Pagani,A., Ladli,M., Nai,A., Verdier,F., Camaschella,C. and Silvestri,L.
    Comment on: PACE4 (PCSK6): another proprotein convertase linked to iron homeostasis?
    Haematologica100, e380-e380. PubMed  Europe PubMed DOI
  26. Pang,X., Pan,J., Gao,P., Wang,Y., Wang,L., Du,B. and Wei,Q.
    A visible light induced photoelectrochemical aptsensor constructed by aligned ZnO@CdTe core shell nanocable arrays/carboxylated g-C3N4 for the detection of proprotein convertase subtilisin/kexin type 6 gene
    Biosens Bioelectron74, 49-58. PubMed  Europe PubMed DOI  A
  27. Wang,F., Wang,L., Jiang,H., Chang,X. and Pan,J.
    Inhibition of PCSK6 may play a protective role in the development of rheumatoid arthritis
    J Rheumatol42, 161-169. PubMed  Europe PubMed DOI  M
    28. 2013
  28. Perisic,L., Hedin,E., Razuvaev,A., Lengquist,M., Osterholm,C., Folkersen,L., Gillgren,P., Paulsson-Berne,G., Ponten,F., Odeberg,J. and Hedin,U.
    Profiling of atherosclerotic lesions by gene and tissue microarrays reveals PCSK6 as a novel protease in unstable carotid atherosclerosis
    Arterioscler Thromb Vasc Biol33, 2432-2443. PubMed  Europe PubMed DOI
  29. Seidah,N.G., Sadr,M.S., Chretien,M. and Mbikay,M.
    The multifaceted proprotein convertases: their unique, redundant, complementary, and opposite functions
    J Biol Chem288, 21473-21481. PubMed  Europe PubMed DOI  V
  30. Turpeinen,H., Ortutay,Z. and Pesu,M.
    Genetics of the first seven proprotein convertase enzymes in health and disease
    Curr Genomics14, 453-467. PubMed  Europe PubMed DOI  V
    31. 2012
  31. Akamatsu,T.
    Proprotein convertase PACE4
    [ISSN:978-0-12-407742-3]3, 3299-3305. DOI
  32. Levesque,C., Fugere,M., Kwiatkowska,A., Couture,F., Desjardins,R., Routhier,S., Moussette,P., Prahl,A., Lammek,B., Appel,J.R., Houghten,R.A., D'Anjou,F., Dory,Y.L., Neugebauer,W. and Day,R.
    The multi-Leu peptide inhibitor discriminates between PACE4 and furin and exhibits antiproliferative effects on prostate cancer cells
    J Med Chem55, 10501-10511. PubMed  Europe PubMed DOI  I
  33. Seidah,N.G. and Prat,A.
    The biology and therapeutic targeting of the proprotein convertases
    Nat Rev Drug Discov11, 367-383. PubMed  Europe PubMed DOI  V
  34. Yuasa,K., Futamatsu,G., Kawano,T., Muroshita,M., Kageyama,Y., Taichi,H., Ishikawa,H., Nagahama,M., Matsuda,Y. and Tsuji,A.
    Subtilisin-like proprotein convertase paired basic amino acid-cleaving enzyme4 is required for chondrogenic differentiation in ATDC5 cells
    FEBS J279, 3997-4009. PubMed  Europe PubMed DOI
    35. 2011
  35. Basak,A., Chen,A., Majumdar,S. and Smith,H.P.
    In vitro assay for protease activity of proprotein convertase subtilisin kexins (PCSKs): an overall review of existing and new methodologies
    Methods Mol Biol768, 127-153. PubMed  Europe PubMed DOI  A
  36. Mesnard,D., Donnison,M., Fuerer,C., Pfeffer,P.L. and Constam,D.B.
    The microenvironment patterns the pluripotent mouse epiblast through paracrine furin and pace4 proteolytic activities
    Genes Dev25, 1871-1880. PubMed  Europe PubMed DOI
  37. Mujoomdar,M.L., Hogan,L.M., Parlow,A.F. and Nachtigal,M.W.
    Pcsk6 mutant mice exhibit progressive loss of ovarian function, altered gene expression, and formation of ovarian pathology
    Reproduction141, 343-355. PubMed  Europe PubMed DOI  K  M
  38. Scerri,T.S., Brandler,W.M., Paracchini,S., Morris,A.P., Ring,S.M., Richardson,A.J., Talcott,J.B., Stein,J. and Monaco,A.P.
    PCSK6 is associated with handedness in individuals with dyslexia
    Hum Mol Genet20, 608-614. PubMed  Europe PubMed DOI
  39. Seidah,N.G.
    The proprotein convertases, 20 years later
    Methods Mol Biol768, 23-57. PubMed  Europe PubMed DOI  V
  40. Seidah,N.G.
    What lies ahead for the proprotein convertases?
    Ann N Y Acad Sci1220, 149-161. PubMed  Europe PubMed DOI  V
    41. 2010
  41. Akamatsu,T.
    Physiological role of a subtilisin-like proprotein convertase, PACE4, in submandibular gland development
    J Oral Biosci52, 81-93. DOI
  42. Bassi,D.E., Zhang,J., Cenna,J., Litwin,S., Cukierman,E. and Klein-Szanto,A.J.
    Proprotein convertase inhibition results in decreased skin cell proliferation, tumorigenesis, and metastasis
    Neoplasia12, 516-526. PubMed  Europe PubMed DOI  I
  43. Tian,S. and Jianhua,W.
    Comparative study of the binding pockets of mammalian proprotein convertases and its implications for the design of specific small molecule inhibitors
    Int J Biol Sci6, 89-95. PubMed  Europe PubMed  P  I
    44. 2009
  44. Akamatsu,T., Azlina,A., Javkhlan,P., Hasegawa,T., Yao,C. and Hosoi,K.
    Salivary gland development: its mediation by a subtilisin-like proprotein convertase, PACE4
    J Med Invest56 Suppl, 241-246. PubMed  Europe PubMed DOI
  45. Rholam,M. and Fahy,C.
    Processing of peptide and hormone precursors at the dibasic cleavage sites
    Cell Mol Life Sci66, 2075-2091. PubMed  Europe PubMed DOI
  46. Yuasa,K., Masuda,T., Yoshikawa,C., Nagahama,M., Matsuda,Y. and Tsuji,A.
    Subtilisin-like proprotein convertase PACE4 is required for skeletal muscle differentiation
    J Biochem146, 407-415. PubMed  Europe PubMed DOI
    47. 2008
  47. Creemers,J.W. and Khatib,A.M.
    Knock-out mouse models of proprotein convertases: unique functions or redundancy?
    Front Biosci13, 4960-4971. PubMed  Europe PubMed DOI  K
  48. Malfait,A.M., Arner,E.C., Song,R.H., Alston,J.T., Markosyan,S., Staten,N., Yang,Z., Griggs,D.W. and Tortorella,M.D.
    Proprotein convertase activation of aggrecanases in cartilage in situ
    Arch Biochem Biophys478, 43-51. PubMed  Europe PubMed DOI  T
  49. Remacle,A.G., Shiryaev,S.A., Oh,E.S., Cieplak,P., Srinivasan,A., Wei,G., Liddington,R.C., Ratnikov,B.I., Parent,A., Desjardins,R., Day,R., Smith,J.W., Lebl,M. and Strongin,A.Y.
    Substrate cleavage analysis of furin and related proprotein convertases. A comparative study
    J Biol Chem283, 20897-20906. PubMed  Europe PubMed DOI  P
    50. 2007
  50. Akamatsu,T., Purwanti,N., Karabasil,M.R., Li,X., Yao,C., Kanamori,N. and Hosoi,K.
    Temporospatially regulated expression of subtilisin-like proprotein convertase PACE4 (SPC4) during development of the rat submandibular gland
    Dev Dyn236, 314-320. PubMed  Europe PubMed DOI
  51. Hall,T., Fok,K.F., Liu,M.M., Zobel,J.F., Marino,M.H., Malfait,A.M., Tortorella,M.D. and Tomasselli,A.G.
    A high performance liquid chromatography assay for monitoring proprotein convertase activity
    J Chromatogr A1148, 46-54. PubMed  Europe PubMed DOI  A
  52. Tsuji,A., Kanie,H., Makise,H., Yuasa,K., Nagahama,M. and Matsuda,Y.
    Engineering of alpha1-antitrypsin variants selective for subtilisin-like proprotein convertases PACE4 and PC6: importance of the P2' residue in stable complex formation of the serpin with proprotein convertase
    Protein Eng Des Sel20, 163-170. PubMed  Europe PubMed DOI
  53. Yuasa,K., Suzue,K., Nagahama,M., Matsuda,Y. and Tsuji,A.
    Transcriptional regulation of subtilisin-like proprotein convertase PACE4 by E2F: possible role of E2F-mediated upregulation of PACE4 in tumor progression
    Gene402, 103-110. PubMed  Europe PubMed DOI
    54. 2006
  54. Scamuffa,N., Calvo,F., Chretien,M., Seidah,N.G. and Khatib,A.M.
    Proprotein convertases: lessons from knockouts
    FASEB J20, 1954-1963. PubMed  Europe PubMed DOI  K  V
    55. 2005
  55. Birsoy,B., Berg,L., Williams,P.H., Smith,J.C., Wylie,C.C., Christian,J.L. and Heasman,J.
    XPACE4 is a localized pro-protein convertase required for mesoderm induction and the cleavage of specific TGFbeta proteins in Xenopus development
    Development132, 591-602. PubMed  Europe PubMed DOI
  56. [YEAR:14-1-2005]Henrich,S., Lindberg,I., Bode,W. and Than,M.E.
    Proprotein convertase models based on the crystal structures of furin and kexin: explanation of their specificity
    J Mol Biol345, 211-227. PubMed  Europe PubMed DOI  S
  57. Nour,N., Mayer,G., Mort,J.S., Salvas,A., Mbikay,M., Morrison,C.J., Overall,C.M. and Seidah,N.G.
    The cysteine-rich domain of the secreted proprotein convertases PC5A and PACE4 functions as a cell surface anchor and interacts with tissue inhibitors of metalloproteinases
    Mol Biol Cell16, 5215-5226. PubMed  Europe PubMed DOI
    58. 2004
  58. Mains,R.E.
    Proprotein convertase PACE4
    [ISSN:0-12-079610-4]2, 1871-1874.  V
    59. 2003
  59. Fu,Y., Campbell,E.J., Shepherd,T.G. and Nachtigal,M.W.
    Epigenetic regulation of proprotein convertase PACE4 gene expression in human ovarian cancer cells
    Mol Cancer Res1, 569-576. PubMed  Europe PubMed
  60. Siegfried,G., Basak,A., Cromlish,J.A., Benjannet,S., Marcinkiewicz,J., Chretien,M., Seidah,N.G. and Khatib,A.M.
    The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis
    J Clin Invest111, 1723-1732. PubMed  Europe PubMed DOI
  61. Taylor,N.A., Van de Ven,W.J. and Creemers,J.W.
    Curbing activation: proprotein convertases in homeostasis and pathology
    FASEB J17, 1215-1227. PubMed  Europe PubMed DOI  K
  62. [YEAR:31-1-2003]Tsuji,A., Sakurai,K., Kiyokage,E., Yamazaki,T., Koide,S., Toida,K., Ishimura,K. and Matsuda,Y.
    Secretory proprotein convertases PACE4 and PC6A are heparin-binding proteins which are localized in the extracellular matrix. Potential role of PACE4 in the activation of proproteins in the extracellular matrix
    Biochim Biophys Acta1645, 95-104. PubMed  Europe PubMed DOI
    63. 2002
  63. Beck,S., Le Good,J.A., Guzman,M., Ben Haim,N., Roy,K., Beermann,F. and Constam,D.B.
    Extraembryonic proteases regulate Nodal signalling during gastrulation
    Nat Cell Biol4, 981-985. PubMed  Europe PubMed DOI
  64. Fugere,M. and Day,R.
    Inhibitors of the subtilase-like pro-protein convertases (SPCs)
    Curr Pharm Des8, 549-562. PubMed  Europe PubMed DOI  V  I
  65. Seidah,N.G. and Prat,A.
    Precursor convertases in the secretory pathway, cytosol and extracellular milieu
    Essays Biochem38, 79-94. PubMed  Europe PubMed
  66. [YEAR:18-1-2002]Taniguchi,T., Kuroda,R., Sakurai,K., Nagahama,M., Wada,I., Tsuji,A. and Matsuda,Y.
    A critical role for the carboxy terminal region of the proprotein convertase, PACE4A, in the regulation of its autocatalytic activation coupled with secretion
    Biochem Biophys Res Commun290, 878-884. PubMed  Europe PubMed DOI
    67. 2001
  67. [YEAR:15-12-2001]Yoshida,I., Koide,S., Hasegawa,S.I., Nakagawara,A., Tsuji,A. and Matsuda,Y.
    Proprotein convertase PACE4 is down-regulated by the basic helix-loop-helix transcription factor hASH-1 and MASH-1
    Biochem J360, 683-689. PubMed  Europe PubMed DOI
    68. 2000
  68. [YEAR:7-6-2000]Akamatsu,T., Matsuda,Y., Tsumura,K., Tada,J., Parvin,M.N., Wei,W., Kanamori,N. and Hosoi,K.
    Highly regulated expression of subtilisin-like proprotein convertase PACE4 (SPC4) during dentinogenesis
    Biochem Biophys Res Commun272, 410-415. PubMed  Europe PubMed DOI
  69. Bassi,D.E., Mahloogi,H. and Klein-Szanto,A.J.
    The proprotein convertases furin and PACE4 play a significant role in tumor progression
    Mol Carcinog28, 63-69. PubMed  Europe PubMed DOI
    70. 1999
  70. [YEAR:1-5-1999]Sucic,J.F., Moehring,J.M., Inocencio,N.M., Luchini,J.W. and Moehring,T.J.
    Endoprotease PACE4 is Ca2+-dependent and temperature-sensitive and can partly rescue the phenotype of a furin-deficient cell strain
    Biochem J339, 639-647. PubMed  Europe PubMed
  71. Tsuji,A., Hashimoto,E., Ikoma,T., Taniguchi,T., Mori,K., Nagahama,M. and Matsuda,Y.
    Inactivation of proprotein convertase, PACE4, by alpha1-antitrypsin Portland (alpha1-PDX), a blocker of proteolytic activation of bone morphogenetic protein during embryogenesis: evidence that PACE4 is able to form an SDS-stable acyl intermediate with alpha1-PDX
    J Biochem126, 591-603. PubMed  Europe PubMed  I
    72. 1997
  72. Gordon,V.M., Rehemtulla,A. and Leppla,S.H.
    A role for PACE4 in the proteolytic activation of anthrax toxin protective antigen
    Infect Immun65, 3370-3375. PubMed  Europe PubMed
  73. [YEAR:1-12-1997]Hubbard,F.C., Goodrow,T.L., Liu,S.C., Brilliant,M.H., Basset,P., Mains,R.E. and Klein-Szanto,A.J.
    Expression of PACE4 in chemically induced carcinomas is associated with spindle cell tumor conversion and increased invasive ability
    Cancer Res57, 5226-5231. PubMed  Europe PubMed
  74. Mains,R.E., Berard,C.A., Denault,J.B., Zhou,A., Johnson,R.C. and Leduc,R.
    PACE4: a subtilisin-like endoprotease with unique properties
    Biochem J321, 587-593. PubMed  Europe PubMed  I
  75. Mori,K., Kii,S., Tsuji,A., Nagahama,M., Imamaki,A., Hayashi,K., Akamatsu,T., Nagamune,H. and Matsuda,Y.
    A novel human PACE4 isoform, PACE4E is an active processing protease containing a hydrophobic cluster at the carboxy terminus
    J Biochem121, 941-948. PubMed  Europe PubMed
  76. Tsuji,A., Hine,C., Tamai,Y., Yonemoto,K., Mori,K., Yoshida,S., Bando,M., Sakai,E., Mori,K., Akamatsu,T. and Matsuda,Y.
    Genomic organization and alternative splicing of human PACE4 (SPC4), kexin-like processing endoprotease
    J Biochem122, 438-452. PubMed  Europe PubMed
    77. 1996
  77. Constam,D.B., Calfon,M. and Robertson,E.J.
    SPC4, SPC6, and the novel protease SPC7 are coexpressed with bone morphogenetic proteins at distinct sites during embryogenesis
    J Cell Biol134, 181-191. PubMed  Europe PubMed DOI
  78. Zhong,M., Benjannet,S., Lazure,C., Munzer,S. and Seidah,N.G.
    Functional analysis of human PACE4-A and PACE4-C isoforms: identification of a new PACE4-CS isoform
    FEBS Lett396, 31-36. PubMed  Europe PubMed DOI
    79. 1995
  79. Brakch,N., Galanopoulou,A.S., Patel,Y.C., Boileau,G. and Seidah,N.G.
    Comparative proteolytic processing of rat prosomatostatin by the convertases PC1, PC2, furin, PACE4 and PC5 in constitutive and regulated secretory pathways
    FEBS Lett362, 143-146. PubMed  Europe PubMed DOI
  80. Dong,W., Marcinkiewicz,M., Vieau,D., Chretien,M., Seidah,N.G. and Day,R.
    Distinct mRNA expression of the highly homologous convertases PC5 and PACE4 in the rat brain and pituitary
    J Neurosci15, 1778-1796. PubMed  Europe PubMed
  81. Mbikay,M., Seidah,N.G., Chretien,M. and Simpson,E.M.
    Chromosomal assignment of the genes for proprotein convertases PC4, PC5, and PACE 4 in mouse and human
    Genomics26, 123-129. PubMed  Europe PubMed DOI
  82. Nagamune,H., Muramatsu,K., Akamatsu,T., Tamai,Y., Izumi,K., Tsuji,A. and Matsuda,Y.
    Distribution of the kexin family proteases in pancreatic islets: PACE4C is specifically expressed in B cells of pancreatic islets
    Endocrinology136, 357-360. PubMed  Europe PubMed DOI
    83. 1994
  83. Tsuji,A., Higashine,K., Hine,C., Mori,K., Tamai,Y., Nagamune,H. and Matsuda,Y.
    Identification of novel cDNAs encoding human kexin-like protease, PACE4 isoforms
    Biochem Biophys Res Commun200, 943-950. PubMed  Europe PubMed DOI
    84. 1993
  84. Creemers,J.W., Kormelink,P.J., Roebroek,A.J., Nakayama,K. and Van de Ven,W.J.
    Proprotein processing activity and cleavage site selectivity of the Kex2-like endoprotease PACE4
    FEBS Lett336, 65-69. PubMed  Europe PubMed DOI
  85. Rehemtulla,A., Barr,P.J., Rhodes,C.J. and Kaufman,R.J.
    PACE4 is a member of the mammalian propeptidase family that has overlapping but not identical substrate specificity to PACE
    Biochemistry32, 11586-11590. PubMed  Europe PubMed DOI
    86. 1992
  86. Steiner,D.F., Smeekens,S.P., Ohagi,S. and Chan,S.J.
    The new enzymology of precursor processing endoproteases
    J Biol Chem267, 23435-23438. PubMed  Europe PubMed

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2025 EBI
Terms of use