$VAR1 = undef;

Summary for peptidase S08.074: PCSK4 peptidase

Names
MEROPS Name	PCSK4 peptidase
Other names	neuroendocrine convertase, PC4, PCSK4, SPC5, SPSK4 g.p. (Homo sapiens), proprotein convertase 4, proprotein convertase subtilisin/kexin type 4

Domain architecture

MEROPS Classification
Classification	Clan SB >> Subclan (none) >> Family S8 >> Subfamily B >> S08.074
Holotype	PCSK4 peptidase (Mus musculus), Uniprot accession P29121 (peptidase unit: 133-423), MERNUM MER0000381
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Serine
Peplist	Included in the Peplist with identifier PL00361
NC-IUBMB	Not yet included in IUBMB recommendations.
Proteolytic events	CutDB database (1 cleavage)
Activity status	human: active (Seidah & Chretien, 2004) mouse: active (Mbikay et al., 1997)
Physiology	Processes various preproteins by cleavage at paired basic amino acids.
Knockout	The fertility of male mice with homozygous deficiency of proprotein convertase 4 was severely impaired, and there were also defects in embryonic development (Mbikay et al., 1997).
Other databases	TREEFAM	http://www.treefam.org/family/TF314277
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	R/-/KR/Rs/val/-/- (based on 103 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	1	4	0	0	3	4	12	8
Pro	0	0	6	0	2	4	2	11
Ala	0	5	3	0	9	19	4	5
Val	4	5	1	0	3	25	3	7
Leu	0	4	1	0	1	15	8	11
Ile	2	0	0	0	0	7	4	0
Met	0	2	0	0	1	0	0	1
Phe	1	3	0	0	6	1	2	1
Tyr	1	0	0	0	6	0	1	0
Trp	0	0	0	0	0	1	0	0
Ser	0	11	2	0	31	3	13	8
Thr	0	8	2	0	1	10	6	6
Cys	0	0	0	0	3	0	0	1
Asn	0	4	0	0	0	0	5	4
Gln	1	10	0	0	5	0	4	3
Asp	0	2	0	0	9	4	12	8
Glu	1	2	1	0	9	0	11	13
Lys	8	18	49	3	0	2	4	3
Arg	77	12	32	100	1	0	2	2
His	2	6	0	0	5	0	2	3