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Literature for peptidase S08.074: PCSK4 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates Pharma

(Topics flags: S Structure, A Assay, I Inhibitor, P Specificity, K Knockout, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2023
  1. Cendron,L., Rothenberger,S., Cassari,L., Dettin,M. and Pasquato,A.
    Proprotein convertases regulate trafficking and maturation of key proteins within the secretory pathway
    Adv Protein Chem Struct Biol (2023) 133, 1-54. PubMed  Europe PubMed DOI  V
    2. 2016
  2. Maluch,I., Walewska,A., Sikorska,E. and Prahl,A.
    [Proprotein convertases - family of serine proteases with a broad spectrum of physiological functions]
    Postepy Biochem (2016) 62, 472-481. PubMed  Europe PubMed  V
    3. 2013
  3. Seidah,N.G., Sadr,M.S., Chretien,M. and Mbikay,M.
    The multifaceted proprotein convertases: their unique, redundant, complementary, and opposite functions
    J Biol Chem (2013) 288, 21473-21481. PubMed  Europe PubMed DOI  V
  4. Turpeinen,H., Ortutay,Z. and Pesu,M.
    Genetics of the first seven proprotein convertase enzymes in health and disease
    Curr Genomics (2013) 14, 453-467. PubMed  Europe PubMed DOI  PMC  EPMC  V
    5. 2012
  5. Mishra,P., Qiu,Q., Gruslin,A., Hidaka,Y., Mbikay,M. and Basak,A.
    In vitro regulatory effect of epididymal serpin CRES on protease activity of proprotein convertase PC4/PCSK4
    Curr Mol Med (2012) 12, 1050-1067. PubMed  Europe PubMed DOI
  6. Seidah,N.G. and Prat,A.
    The biology and therapeutic targeting of the proprotein convertases
    Nat Rev Drug Discov (2012) 11, 367-383. PubMed  Europe PubMed DOI  V
  7. Seidah,N.G.
    Proprotein convertase 4
    [ISSN:978-0-12-407742-3] (2012) 3, 3295-3299. DOI
  8. Tardif,S., Guyonnet,B., Cormier,N. and Cornwall,G.A.
    Alteration in the processing of the ACRBP/sp32 protein and sperm head/acrosome malformations in proprotein convertase 4 (PCSK4) null mice
    Mol Hum Reprod (2012) 18, 298-307. PubMed  Europe PubMed DOI  K
    9. 2011
  9. Basak,A., Chen,A., Majumdar,S. and Smith,H.P.
    In vitro assay for protease activity of proprotein convertase subtilisin kexins (PCSKs): an overall review of existing and new methodologies
    Methods Mol Biol (2011) 768, 127-153. PubMed  Europe PubMed DOI  A
  10. Gyamera-Acheampong,C., Sirois,F., Denis,N.J., Mishra,P., Figeys,D., Basak,A. and Mbikay,M.
    The precursor to the germ cell-specific PCSK4 proteinase is inefficiently activated in transfected somatic cells: evidence of interaction with the BiP chaperone
    Mol Cell Biochem (2011) 348, 43-52. PubMed  Europe PubMed DOI
  11. Seidah,N.G.
    What lies ahead for the proprotein convertases?
    Ann N Y Acad Sci (2011) 1220, 149-161. PubMed  Europe PubMed DOI  V
  12. Seidah,N.G.
    The proprotein convertases, 20 years later
    Methods Mol Biol (2011) 768, 23-57. PubMed  Europe PubMed DOI  V
    13. 2010
  13. Tian,S. and Jianhua,W.
    Comparative study of the binding pockets of mammalian proprotein convertases and its implications for the design of specific small molecule inhibitors
    Int J Biol Sci (2010) 6, 89-95. PubMed  Europe PubMed  PMC  EPMC  P  I
    14. 2009
  14. Gyamera-Acheampong,C. and Mbikay,M.
    Proprotein convertase subtilisin/kexin type 4 in mammalian fertility: a review
    Hum Reprod Update (2009) 15, 237-247. PubMed  Europe PubMed DOI  V
  15. Rholam,M. and Fahy,C.
    Processing of peptide and hormone precursors at the dibasic cleavage sites
    Cell Mol Life Sci (2009) 66, 2075-2091. PubMed  Europe PubMed DOI
    16. 2008
  16. Basak,A., Shervani,N.J., Mbikay,M. and Kolajova,M.
    Recombinant proprotein convertase 4 (PC4) from Leishmania tarentolae expression system: purification, biochemical study and inhibitor design
    Protein Expr Purif (2008) 60, 117-126. PubMed  Europe PubMed DOI  E  I
  17. Creemers,J.W. and Khatib,A.M.
    Knock-out mouse models of proprotein convertases: unique functions or redundancy?
    Front Biosci (2008) 13, 4960-4971. PubMed  Europe PubMed DOI  K
  18. Remacle,A.G., Shiryaev,S.A., Oh,E.S., Cieplak,P., Srinivasan,A., Wei,G., Liddington,R.C., Ratnikov,B.I., Parent,A., Desjardins,R., Day,R., Smith,J.W., Lebl,M. and Strongin,A.Y.
    Substrate cleavage analysis of furin and related proprotein convertases. A comparative study
    J Biol Chem (2008) 283, 20897-20906. PubMed  Europe PubMed DOI  PMC  EPMC  P
    19. 2006
  19. [YEAR:21-12-2006]Gyamera-Acheampong,C., Tantibhedhyangkul,J., Weerachatyanukul,W., Tadros,H., Xu,H., van de Loo,J.W., Pelletier,R.M., Tanphaichitr,N. and Mbikay,M.
    Sperm from mice genetically deficient for the PCSK4 proteinase exhibit accelerated capacitation, precocious acrosome reaction, reduced binding to egg zona pellucida, and impaired fertilizing ability
    Biol Reprod (21-12-2006) 74, 666-673. PubMed  Europe PubMed DOI  K
  20. Scamuffa,N., Calvo,F., Chretien,M., Seidah,N.G. and Khatib,A.M.
    Proprotein convertases: lessons from knockouts
    FASEB J (2006) 20, 1954-1963. PubMed  Europe PubMed DOI  K  V
    21. 2005
  21. [YEAR:14-1-2005]Henrich,S., Lindberg,I., Bode,W. and Than,M.E.
    Proprotein convertase models based on the crystal structures of furin and kexin: explanation of their specificity
    J Mol Biol (14-1-2005) 345, 211-227. PubMed  Europe PubMed DOI  S
  22. [YEAR:20-4-2005]Nelsen,S., Berg,L., Wong,C. and Christian,J.L.
    Proprotein convertase genes in Xenopus development
    Dev Dyn (20-4-2005) 233, 1038-1044. PubMed  Europe PubMed DOI
  23. [YEAR:2-8-2005]Qiu,Q., Basak,A., Mbikay,M., Tsang,B.K. and Gruslin,A.
    Role of pro-IGF-II processing by proprotein convertase 4 in human placental development
    Proc Natl Acad Sci U S A (2-8-2005) 102, 11047-11052. PubMed  Europe PubMed DOI  PMC  EPMC
    24. 2004
  24. [YEAR:18-2-2004]Basak,S., Chretien,M., Mbikay,M. and Basak,A.
    In vitro elucidation of substrate specificity and bioassay of proprotein convertase 4 using intramolecularly quenched fluorogenic peptides
    Biochem J (18-2-2004) 380, 505-514. PubMed  Europe PubMed DOI  PMC  EPMC  A
  25. Seidah,N.G. and Chretien,M.
    Proprotein convertase 4
    [ISSN:0-12-079610-4] (2004) 2, 1868-1870.  V
    26. 2003
  26. Taylor,N.A., Van de Ven,W.J. and Creemers,J.W.
    Curbing activation: proprotein convertases in homeostasis and pathology
    FASEB J (2003) 17, 1215-1227. PubMed  Europe PubMed DOI  K
    27. 2002
  27. Fugere,M. and Day,R.
    Inhibitors of the subtilase-like pro-protein convertases (SPCs)
    Curr Pharm Des (2002) 8, 549-562. PubMed  Europe PubMed DOI  V  I
    28. 2001
  28. Tadros,H., Chretien,M. and Mbikay,M.
    The testicular germ-cell protease PC4 is also expressed in macrophage-like cells of the ovary
    J Reprod Immunol (2001) 49, 133-152. PubMed  Europe PubMed DOI
    29. 2000
  29. Li,M., Mbikay,M. and Arimura,A.
    Pituitary adenylate cyclase-activating polypeptide precursor is processed solely by prohormone convertase 4 in the gonads
    Endocrinology (2000) 141, 3723-3730. PubMed  Europe PubMed DOI
  30. Li,M., Mbikay,M., Nakayama,K., Miyata,A. and Arimura,A.
    Prohormone convertase PC4 processes the precursor of PACAP in the testis
    Ann N Y Acad Sci (2000) 921, 333-339. PubMed  Europe PubMed
    31. 1999
  31. [YEAR:1-10-1999]Basak,A., Toure,B.B., Lazure,C., Mbikay,M., Chretien,M. and Seidah,N.G.
    Enzymic characterization in vitro of recombinant proprotein convertase PC4
    Biochem J (1-10-1999) 343, 29-37. PubMed  Europe PubMed DOI  PMC  EPMC  I
    32. 1997
  32. [YEAR:24-6-1997]Mbikay,M., Tadros,H., Ishida,N., Lerner,C.P., De Lamirande,E., Chen,A., El-Alfy,M., Clermont,Y., Seidah,N.G., Chretien,M., Gagnon,C. and Simpson,E.M.
    Impaired fertility in mice deficient for the testicular germ-cell protease PC4
    Proc Natl Acad Sci U S A (24-6-1997) 94, 6842-6846. PubMed  Europe PubMed DOI  PMC  EPMC  K
    33. 1995
  33. Mbikay,M., Seidah,N.G., Chretien,M. and Simpson,E.M.
    Chromosomal assignment of the genes for proprotein convertases PC4, PC5, and PACE 4 in mouse and human
    Genomics (1995) 26, 123-129. PubMed  Europe PubMed DOI
    34. 1994
  34. Mbikay,M., Raffin-Sanson,M.L., Tadros,H., Sirois,F., Seidah,N.G. and Chretien,M.
    Structure of the gene for the testis-specific proprotein convertase 4 and of its alternate messenger RNA isoforms
    Genomics (1994) 20, 231-237. PubMed  Europe PubMed DOI
  35. Seidah,N.G. and Chretien,M.
    Pro-protein convertases of subtilisin/kexin family
    Methods Enzymol (1994) 244, 175-188. PubMed  Europe PubMed DOI  V
    36. 1993
  36. Torii,S., Yamagishi,T., Murakami,K. and Nakayama,K.
    Localization of Kex2-like processing endoproteases, furin and PC4, within mouse testis by in situ hybridization
    FEBS Lett (1993) 316, 12-16. PubMed  Europe PubMed DOI
    37. 1992
  37. Seidah,N.G., Day,R., Hamelin,J., Gaspar,A., Collard,M.W. and Chretien,M.
    Testicular expression of PC4 in the rat: Molecular diversity of a novel germ cell-specific Kex2/subtilisin-like proprotein convertase
    Mol Endocrinol (1992) 6, 1559-1570. PubMed  Europe PubMed DOI
  38. Steiner,D.F., Smeekens,S.P., Ohagi,S. and Chan,S.J.
    The new enzymology of precursor processing endoproteases
    J Biol Chem (1992) 267, 23435-23438. PubMed  Europe PubMed

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