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Literature for peptidase S08.074: PCSK4 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates Pharma

(Topics flags: S Structure, A Assay, I Inhibitor, P Specificity, K Knockout, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2023
  1. Cendron,L., Rothenberger,S., Cassari,L., Dettin,M. and Pasquato,A.<br>Proprotein convertases regulate trafficking and maturation of key proteins within the secretory pathway<br>Adv Protein Chem Struct Biol (2023) 133, 1-54. PubMed  Europe PubMed DOI  V
    2. 2016
  2. Maluch,I., Walewska,A., Sikorska,E. and Prahl,A.<br>[Proprotein convertases - family of serine proteases with a broad spectrum of physiological functions]<br>Postepy Biochem (2016) 62, 472-481. PubMed  Europe PubMed  V
    3. 2013
  3. Seidah,N.G., Sadr,M.S., Chretien,M. and Mbikay,M.<br>The multifaceted proprotein convertases: their unique, redundant, complementary, and opposite functions<br>J Biol Chem (2013) 288, 21473-21481. PubMed  Europe PubMed DOI  V
  4. Turpeinen,H., Ortutay,Z. and Pesu,M.<br>Genetics of the first seven proprotein convertase enzymes in health and disease<br>Curr Genomics (2013) 14, 453-467. PubMed  Europe PubMed DOI  PMC  EPMC  V
    5. 2012
  5. Mishra,P., Qiu,Q., Gruslin,A., Hidaka,Y., Mbikay,M. and Basak,A.<br>In vitro regulatory effect of epididymal serpin CRES on protease activity of proprotein convertase PC4/PCSK4<br>Curr Mol Med (2012) 12, 1050-1067. PubMed  Europe PubMed DOI
  6. Seidah,N.G. and Prat,A.<br>The biology and therapeutic targeting of the proprotein convertases<br>Nat Rev Drug Discov (2012) 11, 367-383. PubMed  Europe PubMed DOI  V
  7. Seidah,N.G.<br>Proprotein convertase 4<br>[ISSN:978-0-12-407742-3] (2012) 3, 3295-3299. DOI
  8. Tardif,S., Guyonnet,B., Cormier,N. and Cornwall,G.A.<br>Alteration in the processing of the ACRBP/sp32 protein and sperm head/acrosome malformations in proprotein convertase 4 (PCSK4) null mice<br>Mol Hum Reprod (2012) 18, 298-307. PubMed  Europe PubMed DOI  K
    9. 2011
  9. Basak,A., Chen,A., Majumdar,S. and Smith,H.P.<br>In vitro assay for protease activity of proprotein convertase subtilisin kexins (PCSKs): an overall review of existing and new methodologies<br>Methods Mol Biol (2011) 768, 127-153. PubMed  Europe PubMed DOI  A
  10. Gyamera-Acheampong,C., Sirois,F., Denis,N.J., Mishra,P., Figeys,D., Basak,A. and Mbikay,M.<br>The precursor to the germ cell-specific PCSK4 proteinase is inefficiently activated in transfected somatic cells: evidence of interaction with the BiP chaperone<br>Mol Cell Biochem (2011) 348, 43-52. PubMed  Europe PubMed DOI
  11. Seidah,N.G.<br>What lies ahead for the proprotein convertases?<br>Ann N Y Acad Sci (2011) 1220, 149-161. PubMed  Europe PubMed DOI  V
  12. Seidah,N.G.<br>The proprotein convertases, 20 years later<br>Methods Mol Biol (2011) 768, 23-57. PubMed  Europe PubMed DOI  V
    13. 2010
  13. Tian,S. and Jianhua,W.<br>Comparative study of the binding pockets of mammalian proprotein convertases and its implications for the design of specific small molecule inhibitors<br>Int J Biol Sci (2010) 6, 89-95. PubMed  Europe PubMed  PMC  EPMC  P  I
    14. 2009
  14. Gyamera-Acheampong,C. and Mbikay,M.<br>Proprotein convertase subtilisin/kexin type 4 in mammalian fertility: a review<br>Hum Reprod Update (2009) 15, 237-247. PubMed  Europe PubMed DOI  V
  15. Rholam,M. and Fahy,C.<br>Processing of peptide and hormone precursors at the dibasic cleavage sites<br>Cell Mol Life Sci (2009) 66, 2075-2091. PubMed  Europe PubMed DOI
    16. 2008
  16. Basak,A., Shervani,N.J., Mbikay,M. and Kolajova,M.<br>Recombinant proprotein convertase 4 (PC4) from Leishmania tarentolae expression system: purification, biochemical study and inhibitor design<br>Protein Expr Purif (2008) 60, 117-126. PubMed  Europe PubMed DOI  E  I
  17. Creemers,J.W. and Khatib,A.M.<br>Knock-out mouse models of proprotein convertases: unique functions or redundancy?<br>Front Biosci (2008) 13, 4960-4971. PubMed  Europe PubMed DOI  K
  18. Remacle,A.G., Shiryaev,S.A., Oh,E.S., Cieplak,P., Srinivasan,A., Wei,G., Liddington,R.C., Ratnikov,B.I., Parent,A., Desjardins,R., Day,R., Smith,J.W., Lebl,M. and Strongin,A.Y.<br>Substrate cleavage analysis of furin and related proprotein convertases. A comparative study<br>J Biol Chem (2008) 283, 20897-20906. PubMed  Europe PubMed DOI  PMC  EPMC  P
    19. 2006
  19. [YEAR:21-12-2006]Gyamera-Acheampong,C., Tantibhedhyangkul,J., Weerachatyanukul,W., Tadros,H., Xu,H., van de Loo,J.W., Pelletier,R.M., Tanphaichitr,N. and Mbikay,M.<br>Sperm from mice genetically deficient for the PCSK4 proteinase exhibit accelerated capacitation, precocious acrosome reaction, reduced binding to egg zona pellucida, and impaired fertilizing ability<br>Biol Reprod (21-12-2006) 74, 666-673. PubMed  Europe PubMed DOI  K
  20. Scamuffa,N., Calvo,F., Chretien,M., Seidah,N.G. and Khatib,A.M.<br>Proprotein convertases: lessons from knockouts<br>FASEB J (2006) 20, 1954-1963. PubMed  Europe PubMed DOI  K  V
    21. 2005
  21. [YEAR:14-1-2005]Henrich,S., Lindberg,I., Bode,W. and Than,M.E.<br>Proprotein convertase models based on the crystal structures of furin and kexin: explanation of their specificity<br>J Mol Biol (14-1-2005) 345, 211-227. PubMed  Europe PubMed DOI  S
  22. [YEAR:20-4-2005]Nelsen,S., Berg,L., Wong,C. and Christian,J.L.<br>Proprotein convertase genes in Xenopus development<br>Dev Dyn (20-4-2005) 233, 1038-1044. PubMed  Europe PubMed DOI
  23. [YEAR:2-8-2005]Qiu,Q., Basak,A., Mbikay,M., Tsang,B.K. and Gruslin,A.<br>Role of pro-IGF-II processing by proprotein convertase 4 in human placental development<br>Proc Natl Acad Sci U S A (2-8-2005) 102, 11047-11052. PubMed  Europe PubMed DOI  PMC  EPMC
    24. 2004
  24. [YEAR:18-2-2004]Basak,S., Chretien,M., Mbikay,M. and Basak,A.<br>In vitro elucidation of substrate specificity and bioassay of proprotein convertase 4 using intramolecularly quenched fluorogenic peptides<br>Biochem J (18-2-2004) 380, 505-514. PubMed  Europe PubMed DOI  PMC  EPMC  A
  25. Seidah,N.G. and Chretien,M.<br>Proprotein convertase 4<br>[ISSN:0-12-079610-4] (2004) 2, 1868-1870.  V
    26. 2003
  26. Taylor,N.A., Van de Ven,W.J. and Creemers,J.W.<br>Curbing activation: proprotein convertases in homeostasis and pathology<br>FASEB J (2003) 17, 1215-1227. PubMed  Europe PubMed DOI  K
    27. 2002
  27. Fugere,M. and Day,R.<br>Inhibitors of the subtilase-like pro-protein convertases (SPCs)<br>Curr Pharm Des (2002) 8, 549-562. PubMed  Europe PubMed DOI  V  I
    28. 2001
  28. Tadros,H., Chretien,M. and Mbikay,M.<br>The testicular germ-cell protease PC4 is also expressed in macrophage-like cells of the ovary<br>J Reprod Immunol (2001) 49, 133-152. PubMed  Europe PubMed DOI
    29. 2000
  29. Li,M., Mbikay,M. and Arimura,A.<br>Pituitary adenylate cyclase-activating polypeptide precursor is processed solely by prohormone convertase 4 in the gonads<br>Endocrinology (2000) 141, 3723-3730. PubMed  Europe PubMed DOI
  30. Li,M., Mbikay,M., Nakayama,K., Miyata,A. and Arimura,A.<br>Prohormone convertase PC4 processes the precursor of PACAP in the testis<br>Ann N Y Acad Sci (2000) 921, 333-339. PubMed  Europe PubMed
    31. 1999
  31. [YEAR:1-10-1999]Basak,A., Toure,B.B., Lazure,C., Mbikay,M., Chretien,M. and Seidah,N.G.<br>Enzymic characterization in vitro of recombinant proprotein convertase PC4<br>Biochem J (1-10-1999) 343, 29-37. PubMed  Europe PubMed DOI  PMC  EPMC  I
    32. 1997
  32. [YEAR:24-6-1997]Mbikay,M., Tadros,H., Ishida,N., Lerner,C.P., De Lamirande,E., Chen,A., El-Alfy,M., Clermont,Y., Seidah,N.G., Chretien,M., Gagnon,C. and Simpson,E.M.<br>Impaired fertility in mice deficient for the testicular germ-cell protease PC4<br>Proc Natl Acad Sci U S A (24-6-1997) 94, 6842-6846. PubMed  Europe PubMed DOI  PMC  EPMC  K
    33. 1995
  33. Mbikay,M., Seidah,N.G., Chretien,M. and Simpson,E.M.<br>Chromosomal assignment of the genes for proprotein convertases PC4, PC5, and PACE 4 in mouse and human<br>Genomics (1995) 26, 123-129. PubMed  Europe PubMed DOI
    34. 1994
  34. Mbikay,M., Raffin-Sanson,M.L., Tadros,H., Sirois,F., Seidah,N.G. and Chretien,M.<br>Structure of the gene for the testis-specific proprotein convertase 4 and of its alternate messenger RNA isoforms<br>Genomics (1994) 20, 231-237. PubMed  Europe PubMed DOI
  35. Seidah,N.G. and Chretien,M.<br>Pro-protein convertases of subtilisin/kexin family<br>Methods Enzymol (1994) 244, 175-188. PubMed  Europe PubMed DOI  V
    36. 1993
  36. Torii,S., Yamagishi,T., Murakami,K. and Nakayama,K.<br>Localization of Kex2-like processing endoproteases, furin and PC4, within mouse testis by in situ hybridization<br>FEBS Lett (1993) 316, 12-16. PubMed  Europe PubMed DOI
    37. 1992
  37. Seidah,N.G., Day,R., Hamelin,J., Gaspar,A., Collard,M.W. and Chretien,M.<br>Testicular expression of PC4 in the rat: Molecular diversity of a novel germ cell-specific Kex2/subtilisin-like proprotein convertase<br>Mol Endocrinol (1992) 6, 1559-1570. PubMed  Europe PubMed DOI
  38. Steiner,D.F., Smeekens,S.P., Ohagi,S. and Chan,S.J.<br>The new enzymology of precursor processing endoproteases<br>J Biol Chem (1992) 267, 23435-23438. PubMed  Europe PubMed

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