$VAR1 = undef;

Summary for peptidase S08.070: kexin

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

 

Names
MEROPS Namekexin
Other namesKEX2 g.p. (Saccharomyces cerevisiae), KexB g.p. (Aspergillus sp.), Krp1 g.p. (Schizosaccharomyces pombe), paired-basic endopeptidase, prohormone-processing endoprotease, yeast cysteine proteinase F (misleading), XPR6 g.p. (Yarrowia lipolytica)
Domain architecture
MEROPS Classification
Classification Clan SB >> Subclan (none) >> Family S8 >> Subfamily B >> S08.070
Holotypekexin (Saccharomyces cerevisiae), Uniprot accession P13134 (peptidase unit: 144-439), MERNUM MER0000364
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00357
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.61
EnzymologyBRENDA database
Proteolytic eventsCutDB database (181 cleavages)
PhysiologyProcesses various preproteins by cleavage at paired basic amino acids.
Other databases PANTHERhttp://www.pantherdb.org/panther/familyList.do?searchType=basic&fieldName=all&listType=6&fieldValue=PTHR42884:SF14
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/K/RScissile bonddae/-/-/- (based on 192 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 4 6 0 0 12 9 14 8
Pro 4 0 0 0 2 15 6 13
Ala 8 25 1 0 42 31 19 16
Val 11 16 1 0 1 35 37 28
Leu 35 3 0 0 3 15 6 5
Ile 13 4 0 0 1 6 9 9
Met 6 3 0 0 3 1 4 2
Phe 4 8 0 0 2 4 1 5
Tyr 1 7 0 0 4 7 2 18
Trp 0 1 0 0 0 1 1 1
Ser 5 16 2 0 16 6 15 10
Thr 5 13 3 0 1 9 2 11
Cys 0 2 0 0 1 1 1 2
Asn 26 9 0 0 4 9 12 11
Gln 15 7 0 0 7 3 6 9
Asp 1 13 1 0 57 20 18 16
Glu 6 18 2 0 32 12 13 12
Lys 28 13 169 1 0 3 14 8
Arg 9 6 13 191 0 2 1 1
His 10 22 0 0 2 1 9 5