Literature for peptidase S08.070: kexin

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, K Knockout, P Specificity, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

2024

Wu,L., Bian,W., Abubakar,Y.S., Lin,J., Yan,H., Zhang,H., Wang,Z., Wu,C., Shim,W. and Lu,G.D. FvKex2 is required for development, virulence, and mycotoxin production in Fusarium verticillioides Appl Microbiol Biotechnol (2024) 108, 228-228. PubMed Europe PubMed DOI PMC EPMC

2023

Jin,Y., Yang,N., Teng,D., Hao,Y., Mao,R. and Wang,J. Molecular Modification of Kex2 P1' Site Enhances Expression and Druggability of Fungal Defensin Antibiotics (Basel) (2023) 12 PubMed Europe PubMed DOI PMC EPMC
Kim,M.J., Park,S.L., Kim,S.H., Park,H.J., Sung,B.H., Sohn,J.H. and Bae,J.H. Modulation of Kex2p Cleavage Site for In Vitro Processing of Recombinant Proteins Produced by Saccharomyces cerevisiae J Microbiol Biotechnol (2023) 33, 1-9. PubMed Europe PubMed DOI

2021

de Souza,A.A., de Andrade,D.M., Siqueira,F.D.S., Di Iorio,J.F., Veloso,M.P., Coelho,C.M., Viegas Junior,C., Gontijo,V.S., Dos Santos,M.H., Meneghetti,M.C.Z., Nader,H.B., Tersariol,I.L.D.S., Juliano,L., Juliano,M.A. and Judice,W.A.S. Semysinthetic biflavonoid Morelloflavone-7,4',7'',3''',4'''-penta-O-butanoyl is a more potent inhibitor of Proprotein Convertases Subtilisin/Kexin PC1/3 than Kex2 and Furin Biochim Biophys Acta Gen Subj (2021) 1865, 130016-130016. PubMed Europe PubMed DOI I

2020

Tomas,A.L., Cardoso,F., de Sousa,B. and Matos,O. Detection of anti-Pneumocystis jirovecii antibodies in human serum using a recombinant synthetic multi-epitope kexin-based antigen Eur J Clin Microbiol Infect Dis (2020) 39, 2205-2209. PubMed Europe PubMed DOI

2018

Huang,Y., Long,Y., Li,S., Lin,T., Wu,J., Zhang,Y. and Lin,Y. Investigation on the processing and improving the cleavage efficiency of furin cleavage sites in Pichia pastoris Microb Cell Fact (2018) 17, 172-172. PubMed Europe PubMed DOI PMC EPMC

2017

Antunes,A.A., Jesus,L.O.P., Manfredi,M.A., de Souza,A.A., Machado,M.F.M., E Silva,P.M., Icimoto,M.Y., Juliano,M.A., Juliano,L. and Judice,W.A.S. Thermodynamic analysis of Kex2 activity: the acylation and deacylation steps are potassium- and substrate-dependent Biophys Chem (2017) 235, 29-39. PubMed Europe PubMed DOI
Koseki,T., Otsuka,M., Mizuno,T. and Shiono,Y. Mutational analysis of Kex2 recognition sites and a disulfide bond in tannase from Aspergillus oryzae Biochem Biophys Res Commun (2017) 482, 1165-1169. PubMed Europe PubMed DOI

2016

Manfredi,M.A., Antunes,A.A., Jesus,L.O., Juliano,M.A., Juliano,L. and Judice,W.A. Specificity characterization of the alpha-mating factor hormone by Kex2 protease Biochimie (2016) 131, 149-158. PubMed Europe PubMed DOI P
Mizutani,O., Shiina,M., Yoshimi,A., Sano,M., Watanabe,T., Yamagata,Y., Nakajima,T., Gomi,K. and Abe,K. Substantial decrease in cell wall alpha-1,3-glucan caused by disruption of the kexB gene encoding a subtilisin-like processing protease in Aspergillus oryzae Biosci Biotechnol Biochem (2016) 80, 1781-1791. PubMed Europe PubMed DOI

2015

Bondaryk,M., Lukowska-Chojnacka,E. and Staniszewska,M. Tetrazole activity against Candida albicans. The role of KEX2 mutations in the sensitivity to (+/-)-1-[5-(2-chlorophenyl)-2H-tetrazol-2-yl]propan-2-yl acetate Bioorg Med Chem Lett (2015) 25, 2657-2663. PubMed Europe PubMed DOI
Sreenivas,S., Krishnaiah,S.M., Govindappa,N., Basavaraju,Y., Kanojia,K., Mallikarjun,N., Natarajan,J., Chatterjee,A. and Sastry,K.N. Enhancement in production of recombinant two-chain Insulin Glargine by over-expression of Kex2 protease in Pichia pastoris Appl Microbiol Biotechnol (2015) 99, 327-336. PubMed Europe PubMed DOI
Wang,J., Zhou,H., Lu,H., Du,T., Luo,Y., Wilson,I.B. and Jin,C. Kexin-like endoprotease KexB is required for N-glycan processing, morphogenesis and virulence in Aspergillus fumigatus Fungal Genet Biol (2015) 76, 57-69. PubMed Europe PubMed DOI

2012

Fuller,R.S. Kexin [ISSN:978-0-12-407742-3] (2012) 3, 3270-3277. DOI

2010

Duan,Y., Zhu,D., Chen,J., Qin,Y. and Wang,J. Gene cloning, expression, and immunological characterization of kexin in rat Pneumocystis carinii Lab Med (2010) 41, 99-103. DOI

2009

Jacob-Wilk,D., Turina,M., Kazmierczak,P. and Van Alfen,N.K. Silencing of Kex2 significantly diminishes the virulence of Cryphonectria parasitica Mol Plant Microbe Interact (2009) 22, 211-221. PubMed Europe PubMed DOI K
Mizutani,O., Furukawa,K., Ichiyanagi,S., Matsuda,Y., Tokuoka,M., Fujioka,T., Yamagata,Y., Gomi,K. and Abe,K. Alternative processing of proproteins in aspergilli KexB gene disruptants under hyperosmotic conditions Biosci Biotechnol Biochem (2009) 73, 40-46. PubMed Europe PubMed DOI K
Rholam,M. and Fahy,C. Processing of peptide and hormone precursors at the dibasic cleavage sites Cell Mol Life Sci (2009) 66, 2075-2091. PubMed Europe PubMed DOI

2008

Bader,O., Krauke,Y. and Hube,B. Processing of predicted substrates of fungal Kex2 proteinases from Candida albicans, C. glabrata, Saccharomyces cerevisiae and Pichia pastoris BMC Microbiol (2008) 8, 116-116. PubMed Europe PubMed DOI PMC EPMC P
Mora-Montes,H.M., Bader,O., Lopez-Romero,E., Zinker,S., Ponce-Noyola,P., Hube,B., Gow,N.A. and Flores-Carreon,A. Kex2 protease converts the endoplasmic reticulum alpha1,2-mannosidase of Candida albicans into a soluble cytosolic form Microbiology (Reading) (2008) 154, 3782-3794. PubMed Europe PubMed DOI
Pozzuolo,S., Breme,U., Salis,B., Taylor,G., Tonon,G. and Orsini,G. Efficient bacterial expression of fusion proteins and their selective processing by a recombinant Kex-1 protease Protein Expr Purif (2008) 59, 334-341. PubMed Europe PubMed DOI
Torres,F.A., Vilaca,R., De Moraes,L.M.P., Reis,V.C. and Felipe,M.S. Expression of a kexin-like gene from the human pathogenic fungus Paracoccidioides brasiliensis in Saccharomyces cerevisiae Med Mycol (2008) 46, 385-388. PubMed Europe PubMed DOI E

2007

[YEAR:15-1-2007]Heiman,M.G., Engel,A. and Walter,P. The Golgi-resident protease Kex2 acts in conjunction with Prm1 to facilitate cell fusion during yeast mating J Cell Biol (15-1-2007) 176, 209-222. PubMed Europe PubMed DOI PMC EPMC
Lazar,N., Brakch,N., Panchal,M., Fahy,C. and Rholam,M. Reactivity of basic amino acid pairs in prohormone processing: model of pro-ocytocin/neurophysin processing domain Arch Biochem Biophys (2007) 463, 231-236. PubMed Europe PubMed DOI P
Wheatley,J.L. and Holyoak,T. Differential P1 arginine and lysine recognition in the prototypical proprotein convertase Kex2 Proc Natl Acad Sci U S A (2007) 104, 6626-6631. PubMed Europe PubMed DOI PMC EPMC P S

2005

[YEAR:2-12-2005]Han,H.E., Rho,S.H., Lee,Y.J. and Park,W.J. Engineering of Kex2 variants exhibiting altered substrate specificity Biochem Biophys Res Commun (2-12-2005) 337, 1102-1106. PubMed Europe PubMed DOI
[YEAR:14-1-2005]Henrich,S., Lindberg,I., Bode,W. and Than,M.E. Proprotein convertase models based on the crystal structures of furin and kexin: explanation of their specificity J Mol Biol (14-1-2005) 345, 211-227. PubMed Europe PubMed DOI S
[YEAR:14-2-2005]Wachter,A. and Schwappach,B. The yeast CLC chloride channel is proteolytically processed by the furin-like protease Kex2p in the first extracellular loop FEBS Lett (14-2-2005) 579, 1149-1153. PubMed Europe PubMed DOI
Werten,M.W. and de Wolf,F.A. Reduced proteolysis of secreted gelatin and Yps1-mediated alpha-factor leader processing in a Pichia pastoris kex2 disruptant Appl Environ Microbiol (2005) 71, 2310-2317. PubMed Europe PubMed DOI PMC EPMC

2004

Fuller,R.S. Kexin [ISSN:0-12-079610-4] (2004) 2, 1849-1854. V
[YEAR:9-3-2004]Holyoak,T., Kettner,C.A., Petsko,G.A., Fuller,R.S. and Ringe,D. Structural basis for differences in substrate selectivity in Kex2 and furin protein convertases Biochemistry (9-3-2004) 43, 2412-2421. PubMed Europe PubMed DOI S I
Rockwell,N.C. and Thorner,J.W. The kindest cuts of all: crystal structures of Kex2 and furin reveal secrets of precursor processing Trends Biochem Sci (2004) 29, 80-87. PubMed Europe PubMed DOI S

2003

[YEAR:10-6-2003]Holyoak,T., Wilson,M.A., Fenn,T.D., Kettner,C.A., Petsko,G.A., Fuller,R.S. and Ringe,D. 2.4 A resolution crystal structure of the prototypical hormone-processing protease Kex2 in complex with an Ala-Lys-Arg boronic acid inhibitor Biochemistry (10-6-2003) 42, 6709-6718. PubMed Europe PubMed DOI S I
Lesage,G., Guimond,J. and Boileau,G. trans-Complementation assay establishes the role of proregion hydrophobic amino acid residues in the biosynthesis of Saccharomyces cerevisiae Kex2p endoprotease Yeast (2003) 20, 397-406. PubMed Europe PubMed DOI
[YEAR:5-12-2003]Punt,P.J., Drint-Kuijvenhoven,A., Lokman,B.C., Spencer,J.A., Jeenes,D., Archer,D.A. and van den Hondel,C.A. The role of the Aspergillus niger furin-type protease gene in processing of fungal proproteins and fusion proteins. Evidence for alternative processing of recombinant (fusion-) proteins J Biotechnol (5-12-2003) 106, 23-32. PubMed Europe PubMed DOI
Tomishige,N., Noda,Y., Adachi,H., Shimoi,H., Takatsuki,A. and Yoda,K. Mutations that are synthetically lethal with a gas1Delta allele cause defects in the cell wall of Saccharomyces cerevisiae Mol Genet Genomics (2003) 269, 562-573. PubMed Europe PubMed DOI

2002

Rockwell,N.C., Krysan,D.J., Komiyama,T. and Fuller,R.S. Precursor processing by kex2/furin proteases Chem Rev (2002) 102, 4525-4548. PubMed Europe PubMed DOI
Venancio,E.J., Daher,B.S., Andrade,R.V., Soares,C.M., Pereira,I.S. and Felipe,M.S. The kex2 gene from the dimorphic and human pathogenic fungus Paracoccidioides brasiliensis Yeast (2002) 19, 1221-1231. PubMed Europe PubMed DOI

2001

Bader,O., Schaller,M., Klein,S., Kukula,J., Haack,K., Muhlschlegel,F., Korting,H.C., Schafer,W. and Hube,B. The KEX2 gene of Candida glabrata is required for cell surface integrity Mol Microbiol (2001) 41, 1431-1444. PubMed Europe PubMed DOI
[YEAR:31-8-2001]Kwon,B.K., Han,K.H., Han,K.Y., Ju,S.M., Hwang,S.G., Jeon,B.H., Han,D.M. and Kim,W.S. Molecular cloning of kpcA gene encoding a Kex2p-like endoprotease from Aspergillus nidulans Mol Cells (31-8-2001) 12, 142-147. PubMed Europe PubMed
[YEAR:23-11-2001]Lesage,G., Tremblay,M., Guimond,J. and Boileau,G. Mechanism of Kex2p inhibition by its proregion FEBS Lett (23-11-2001) 508, 332-336. PubMed Europe PubMed DOI
[YEAR:15-4-2001]Oda,K., Oyama,H., Ito,S., Fukiharu,M., Miyagawa,Y., Takahashi,S., Hirose,M., Kikuchi,N., Nakayama,T. and Shibano,Y. Cloning and rational mutagenesis of kexstatin I, a potent proteinaceous inhibitor of Kex2 proteinase Biochem J (15-4-2001) 355, 339-346. PubMed Europe PubMed DOI PMC EPMC
[YEAR:19-10-2001]Rockwell,N.C. and Fuller,R.S. Differential utilization of enzyme-substrate interactions for acylation but not deacylation during the catalytic cycle of Kex2 protease J Biol Chem (19-10-2001) 276, 38394-38399. PubMed Europe PubMed DOI

2000

Jalving,R., Van de Vondervoort,P.J.I., Visser,J. and Schaap,P.J. Characterization of the kexin-like maturase of Aspergillus niger Appl Environ Microbiol (2000) 66, 363-368. PubMed Europe PubMed PMC EPMC
[YEAR:12-12-2000]Komiyama,T. and Fuller,R.S. Engineered eglin c variants inhibit yeast and human proprotein processing proteases, Kex2 and furin Biochemistry (12-12-2000) 39, 15156-15165. PubMed Europe PubMed DOI

1998

[YEAR:1-9-1998]Bevan,A., Brenner,C. and Fuller,R.S. Quantitative assessment of enzyme specificity in vivo: P2 recognition by Kex2 protease defined in a genetic system Proc Natl Acad Sci U S A (1-9-1998) 95, 10384-10389. PubMed Europe PubMed DOI PMC EPMC P
Goller,S.P., Schoisswohl,D., Baron,M., Parriche,M. and Kubicek,C.P. Role of endoproteolytic dibasic proprotein processing in maturation of secretory proteins in Trichoderma reesei Appl Environ Microbiol (1998) 64, 3202-3208. PubMed Europe PubMed PMC EPMC
Oluwatosin,Y.E. and Kane,P.M. Mutations in the yeast KEX2 gene cause a Vma(-)-like phenotype: a possible role for the KEX2 endoprotease in vacuolar acidification Mol Cell Biol (1998) 18, 1534-1543. PubMed Europe PubMed PMC EPMC
Powner,D. and Davey,J. Activation of the kexin from Schizosaccharomyces pombe requires internal cleavage of its initially cleaved prosequence Mol Cell Biol (1998) 18, 400-408. PubMed Europe PubMed PMC EPMC
[YEAR:10-3-1998]Rockwell,N.C. and Fuller,R.S. Interplay between S1 and S4 subsites in Kex2 protease: Kex2 exhibits dual specificity for the P4 side chain Biochemistry (10-3-1998) 37, 3386-3391. PubMed Europe PubMed DOI P

1997

[YEAR:14-11-1997]Newport,G. and Agabian,N. KEX2 influences Candida albicans proteinase secretion and hyphal formation J Biol Chem (14-11-1997) 272, 28954-28961. PubMed Europe PubMed DOI
Rockwell,N.C., Wang,G.T., Krafft,G.A. and Fuller,R.S. Internally consistent libraries of fluorogenic substrates demonstrate that Kex2 protease specificity is generated by multiple mechanisms Biochemistry (1997) 36, 1912-1917. PubMed Europe PubMed DOI P

1995

Chaudhuri,B. and Stephan,C. A C-terminal domain, which prevents secretion of the neuroendocrine protein 7B2 in Saccharomyces cerevisiae, inhibits Kex2 yet is processed by the Yap3 protease FEBS Lett (1995) 364, 91-97. PubMed Europe PubMed DOI
Diefenbach-Jagger,H., Brenner,C., Kemp,B.E., Baron,W., McLean,J., Martin,T.J. and Moseley,J.M. Arg21 is the preferred kexin cleavage site in parathyroid-hormone-related protein Eur J Biochem (1995) 229, 91-98. PubMed Europe PubMed DOI
Komano,H. and Fuller,R.S. Shared functions in vivo of a glycosyl-phosphatidylinositol-linked aspartyl protease, Mkc7, and the proprotein processing protease Kex2 in yeast Proc Natl Acad Sci U S A (1995) 92, 10752-10756. PubMed Europe PubMed DOI PMC EPMC

1994

Bourbonnais,Y., Germain,D., Ash,J. and Thomas,D.Y. Cleavage of prosomatostatins by the yeast Yap3 and Kex2 endoprotease Biochimie (1994) 76, 226-233. PubMed Europe PubMed
Davey,J., Davis,K., Imai,Y., Yamamoto,M. and Matthews,G. Isolation and characterization of krp, a dibasic endopeptidase required for cell viability in the fission yeast Schizosaccharomyces pombe EMBO J (1994) 13, 5910-5921. PubMed Europe PubMed PMC EPMC
Enderlin,C.S. and Ogrydziak,D.M. Cloning, nucleotide sequence and functions of XPR6, which codes for a dibasic processing endoprotease from the yeast Yarrowia lipolytica Yeast (1994) 10, 67-79. PubMed Europe PubMed DOI

1993

Brenner,C., Bevan,A. and Fuller,R.S. Specificity and activity of the kex2 protease: from yeast genetics to enzyme kinetics Protein Eng Des Sel (1993) 6, 42- DOI

1992

[YEAR:16-3-1992]Germain,D., Dumas,F., Vernet,T., Bourbonnais,Y., Thomas,D.Y. and Boileau,G. The pro-region of the Kex2 endoprotease of Saccharomyces cerevisiae is removed by self-processing FEBS Lett (16-3-1992) 299, 283-286. PubMed Europe PubMed DOI

1991

Fabre,E., Nicaud,J.M., Lopez,M.C. and Gaillardin,C. Role of the proregion in the production and secretion of the Yarrowia lipolytica alkaline extracellular protease J Biol Chem (1991) 266, 3782-3790. PubMed Europe PubMed

1990

van den Ouweland,A.M.W., van Duijnhoven,H.L.P., Keizer,G.D., Dorssers,L.C.J. and Van de Ven,W.J. Structural homology between the human fur gene product and the subtilisin-like protease encoded by yeast KEX2 Nucleic Acids Res (1990) 18, 664-664. PubMed Europe PubMed DOI PMC EPMC

1989

Fuller,R.S., Brake,A. and Thorner,J. Yeast prohormone processing enzyme (KEX2 gene product) is a Ca2+-dependent serine protease Proc Natl Acad Sci U S A (1989) 86, 1434-1438. PubMed Europe PubMed PMC EPMC
Mizuno,K., Nakamura,T., Ohshima,T., Tanaka,S. and Matsuo,H. Characterization of KEX2-encoded endopeptidase from yeast Saccharomyces cerevisiae Biochem Biophys Res Commun (1989) 159, 305-311. PubMed Europe PubMed I

1988

Mizuno,K., Nakamura,T., Ohshima,T., Tanaka,S. and Matsuo,H. Yeast KEX2 gene encodes an endopeptidase homologous to subtilisin-like serine proteases Biochem Biophys Res Commun (1988) 156, 246-254. PubMed Europe PubMed
Tanguy-Rougeau,C., Wesolowski-Louvel,M. and Fukuhara,H. The Kluyveromyces lactis KEX1 gene encodes a subtilisin-type serine proteinase FEBS Lett (1988) 234, 464-470. PubMed Europe PubMed
[YEAR:8-7-1988]Thomas,G., Thorne,B.A., Thomas,L., Allen,R.G., Hruby,D.E., Fuller,R. and Thorner,J. Yeast KEX2 endopeptidase correctly cleaves a neuroendocrine prohormone in mammalian cells Science (8-7-1988) 241, 226-230. PubMed Europe PubMed

1987

[YEAR:16-1-1987]Bathurst,I.C., Brennan,S.O., Carrell,R.W., Cousens,L.S., Brake,A.J. and Barr,P.J. Yeast KEX2 protease has the properties of a human proalbumin converting enzyme Science (16-1-1987) 235, 348-350. PubMed Europe PubMed
Davidow,L.S., O'Donnell,M.M., Kaczmarek,F.S., Pereira,D.A., DeZeeuw,J.R. and Franke,A.E. Cloning and sequencing of the alkaline extracellular protease gene of Yarrowia lipolytica J Bacteriol (1987) 169, 4621-4629. PubMed Europe PubMed PMC EPMC

1985

Achstetter,T. and Wolf,D.H. Hormone processing and membrane-bound proteinases in yeast EMBO J (1985) 4, 173-177. PubMed Europe PubMed PMC EPMC
Mizuno,K. and Matsuo,H. Pheromone-processing protease of the yeast Saccharomyces cerevisiae - a reply Nature (1985) 314, 384-385. DOI
Thorner,J. Pheromone-processing protease of the yeast Saccharomyces cerevisiae Nature (1985) 314, 384-385. PubMed Europe PubMed DOI

1984

Julius,D., Brake,A., Blair,L., Kunisawa,R. and Thorner,J. Isolation of the putative structural gene for the lysine- arginine-cleaving endopeptidase required for processing of yeast prepro-alpha-factor Cell (1984) 37, 1075-1089. PubMed Europe PubMed
Mizuno,K. and Matsuo,H. A novel protease from yeast with specificity towards paired basic residues Nature (1984) 309, 558-560. PubMed Europe PubMed