$VAR1 = undef;

Summary for peptidase S01.280: lysyl endopeptidase (bacteria)

Names
MEROPS Name	lysyl endopeptidase (bacteria)
Other names	Achromobacter proteinase I, achromopeptidase, endopeptidase Lys-C, LepA peptidase (Lysobacter sp.), LepB peptidase (Lysobacter sp.)

Domain architecture

MEROPS Classification
Classification	Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily D >> S01.280
Holotype	lysyl endopeptidase (bacteria) (Achromobacter lyticus), Uniprot accession P15636 (peptidase unit: 226-447), MERNUM MER0000277
History	Identifier created: MEROPS 3.30 (20 July 1999)

Activity
Catalytic type	Serine
Peplist	Included in the Peplist with identifier PL00335
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.50
Enzymology	BRENDA database
Proteolytic events	CutDB database (4 cleavages)
Biotechnology	Used in amino acid sequencing of proteins.
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/-/-/K-/-/-/- (based on 809 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	46	42	52	0	44	51	39	45
Pro	45	27	50	0	1	38	36	40
Ala	53	58	55	0	72	58	49	51
Val	39	44	39	0	47	51	48	41
Leu	94	86	94	0	70	82	78	63
Ile	26	51	33	0	33	45	46	38
Met	27	33	31	0	27	24	26	21
Phe	20	27	20	0	17	27	21	30
Tyr	22	21	15	0	21	29	18	20
Trp	2	4	7	0	8	11	6	4
Ser	67	65	58	0	70	49	60	73
Thr	48	38	26	0	43	41	47	26
Cys	7	18	14	0	16	12	13	14
Asn	37	27	33	0	49	31	27	37
Gln	45	35	39	0	40	47	46	54
Asp	49	43	46	0	52	37	33	46
Glu	74	70	83	0	60	46	77	85
Lys	58	62	48	809	59	58	68	48
Arg	35	39	55	0	64	49	47	47
His	12	16	9	0	15	20	21	23