$VAR1 = undef;

Summary for peptidase S01.150: mast cell peptidase 5 (mouse numbering)

Names
MEROPS Name	mast cell peptidase 5 (mouse numbering)
Other names	mast cell protease 5 (mouse numbering), mMCP-5, rMCP-5, chymase 5 (Mus musculus), chymase 2 (Mesocricetus auratus), hamster chymase 2, mast cell protease 2 (Meriones unguiculatus), mast cell protease 5 (Rattus norvegicus)

Domain architecture

MEROPS Classification
Classification	Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.150
Holotype	mast cell peptidase 5 (mouse numbering) (Mus musculus), Uniprot accession P21844 (peptidase unit: 22-247), MERNUM MER0000121
History	Identifier created: MEROPS 3.02 (25 June 1998)

Activity
Catalytic type	Serine
Peplist	Included in the Peplist with identifier PL00280
NC-IUBMB	Not yet included in IUBMB recommendations.
Knockout	Mice null for mast cell peptidase 5 (mMCP-5) showed reduction of muscle injury due to ischemia with subsequent reperfusion (IR) injury, leading the authors to propose a cytotoxic activity of this mast cell-specific peptidase, and to conclude that mMCP-5 is critical for irreversible IR injury of skeletal muscle (Abonia et al., 2005).
Other databases	PANTHER	http://www.pantherdb.org/panther/familyList.do?searchType=basic&fieldName=all&listType=6&fieldValue=PTHR24271:SF24
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	g/lv/lv/Viap-/eld/-/h (based on 44 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	9	0	1	0	0	1	1	3
Pro	8	1	3	3	0	0	0	0
Ala	3	3	4	4	3	0	2	3
Val	7	11	12	27	4	0	7	6
Leu	2	14	13	0	3	11	4	6
Ile	0	0	0	8	4	2	1	3
Met	1	2	2	0	3	1	1	0
Phe	2	0	0	2	1	0	3	1
Tyr	0	0	1	0	1	1	0	0
Trp	0	0	0	0	2	0	1	2
Ser	0	1	0	0	7	1	6	2
Thr	2	4	5	0	4	1	2	1
Cys	1	0	0	0	0	1	0	0
Asn	0	0	0	0	3	0	0	0
Gln	1	1	2	0	2	1	1	0
Asp	0	0	0	0	0	6	0	0
Glu	1	5	0	0	2	15	0	0
Lys	2	0	1	0	0	0	3	0
Arg	2	2	0	0	5	0	4	4
His	0	0	0	0	0	0	5	10

Mouse genetics
Gene symbol	Position	Megabases	Ensembl	Entrez gene	MGI
Mcpt5	14:C1		ENSMUSG00000022225	17228	MGI:96941