Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Literature for peptidase S01.150: mast cell peptidase 5 (mouse numbering)

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, I Inhibitor, K Knockout, P Specificity, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2018
  1. Thorpe,M., Fu,Z., Albat,E., Akula,S., de Garavilla,L., Kervinen,J. and Hellman,L.<br>Extended cleavage specificities of mast cell proteases 1 and 2 from golden hamster: classical chymase and an elastolytic protease comparable to rat and mouse MCP-5<br>PLoS ONE (2018) 13, e0207826-e0207826. PubMed  Europe PubMed DOI  P
    2. 2017
  2. Stevens,R.L., McNeil,H.P., Wensing,L.A., Shin,K., Wong,G.W., Hansbro,P.M. and Krilis,S.A.<br>Experimental arthritis is dependent on mouse mast cell protease-5<br>J Biol Chem (2017) 292, 5392-5404. PubMed  Europe PubMed DOI  K
    3. 2014
  3. Bankova,L.G., Lezcano,C., Pejler,G., Stevens,R.L., Murphy,G.F., Austen,K.F. and Gurish,M.F.<br>Mouse mast cell proteases 4 and 5 mediate epidermal injury through disruption of tight junctions<br>J Immunol (2014) 192, 2812-2820. PubMed  Europe PubMed DOI
    4. 2012
  4. Caughey,G.H.<br>Chymases<br>[ISSN:978-0-12-407742-3] (2012) 3, 2675-2683. DOI
  5. Wang,S.B., Zhu,X.M., Gao,F., Pang,X.B. and Du,G.H.<br>[High-throughput screening for hamster chymase 2 inhibitors]<br>Yao Xue Xue Bao (2012) 47, 168-173. PubMed  Europe PubMed  I
    6. 2010
  6. Kervinen,J., Crysler,C., Bayoumy,S., Abad,M.C., Spurlino,J., Deckman,I., Greco,M.N., Maryanoff,B.E. and de Garavilla,L.<br>Potency variation of small-molecule chymase inhibitors across species<br>Biochem Pharmacol (2010) 80, 1033-1041. PubMed  Europe PubMed DOI  I
  7. Trivedi,N.N. and Caughey,G.H.<br>Mast cell peptidases: chameleons of innate immunity and host defense<br>Am J Respir Cell Mol Biol (2010) 42, 257-267. PubMed  Europe PubMed DOI
  8. Younan,G., Suber,F., Xing,W., Shi,T., Kunori,Y., Abrink,M., Pejler,G., Schlenner,S.M., Rodewald,H.R., Moore,F.D., Jr., Stevens,R.L., Adachi,R., Austen,K.F. and Gurish,M.F.<br>The inflammatory response after an epidermal burn depends on the activities of mouse mast cell proteases 4 and 5<br>J Immunol (2010) 185, 7681-7690. PubMed  Europe PubMed DOI
    9. 2008
  9. Kervinen,J., Abad,M., Crysler,C., Kolpak,M., Mahan,A.D., Masucci,J.A., Bayoumy,S., Cummings,M.D., Yao,X., Olson,M., de Garavilla,L., Kuo,L., Deckman,I. and Spurlino,J.<br>Structural basis for elastolytic substrate specificity in rodent alpha-chymases<br>J Biol Chem (2008) 283, 427-436. PubMed  Europe PubMed DOI  P  S
    10. 2007
  10. Abraham,D., Oster,H., Huber,M. and Leitges,M.<br>The expression pattern of three mast cell specific proteases during mouse development<br>Mol Immunol (2007) 44, 732-740. PubMed  Europe PubMed DOI
    11. 2005
  11. [YEAR:1-6-2005]Abonia,J.P., Friend,D.S., Austen,W.G., Jr., Moore,F.D., Jr., Carroll,M.C., Chan,R., Afnan,J., Humbles,A., Gerard,C., Knight,P., Kanaoka,Y., Yasuda,S., Morokawa,N., Austen,K.F., Stevens,R.L. and Gurish,M.F.<br>Mast cell protease 5 mediates ischemia-reperfusion injury of mouse skeletal muscle<br>J Immunol (1-6-2005) 174, 7285-7291. PubMed  Europe PubMed
  12. [YEAR:21-2-2005]Russo,A., Russo,G., Peticca,M., Pietropaolo,C., Di Rosa,M. and Iuvone,T.<br>Inhibition of granuloma-associated angiogenesis by controlling mast cell mediator release: role of mast cell protease-5<br>Br J Pharmacol (21-2-2005) 145, 24-33. PubMed  Europe PubMed DOI  PMC  EPMC
    13. 2004
  13. Caughey,G.H.<br>Chymases<br>[ISSN:0-12-079610-4] (2004) 2, 1531-1535.  V
  14. Li,M., Liu,K., Michalicek,J., Angus,J.A., Hunt,J.E., Dell'Italia,L.J., Feneley,M.P., Graham,R.M. and Husain,A.<br>Involvement of chymase-mediated angiotensin II generation in blood pressure regulation<br>J Clin Invest (2004) 114, 112-120. PubMed  Europe PubMed DOI  PMC  EPMC
    15. 2003
  15. Henningsson,F., Wolters,P., Chapman,H.A., Caughey,G.H. and Pejler,G.<br>Mast cell cathepsins C and S control levels of carboxypeptidase A and the chymase, mouse mast cell protease 5<br>Biol Chem (2003) 384, 1527-1531. PubMed  Europe PubMed DOI
  16. [YEAR:10-10-2003]Karlson,U., Pejler,G., Tomasini-Johansson,B. and Hellman,L.<br>Extended substrate specificity of rat mast cell protease 5, a rodent alpha-chymase with elastase-like primary specificity<br>J Biol Chem (10-10-2003) 278, 39625-39631. PubMed  Europe PubMed DOI  P
    17. 2002
  17. Kunori,Y., Koizumi,M., Masegi,T., Kasai,H., Kawabata,H., Yamazaki,Y. and Fukamizu,A.<br>Rodent alpha-chymases are elastase-like proteases<br>Eur J Biochem (2002) 269, 5921-5930. PubMed  Europe PubMed DOI
    18. 2001
  18. Kakizoe,E., Shiota,N., Tanabe,Y., Shimoura,K., Kobayashi,Y. and Okunishi,H.<br>Isoform-selective upregulation of mast cell chymase in the development of skin fibrosis in scleroderma model mice<br>J Invest Dermatol (2001) 116, 118-123. PubMed  Europe PubMed DOI
    19. 1999
  19. [YEAR:15-3-1999]Jippo,T., Lee,Y.M., Katsu,Y., Tsujino,K., Morii,E., Kim,D.K., Kim,H.M. and Kitamura,Y.<br>Deficient transcription of mouse mast cell protease 4 gene in mutant mice of mi/mi genotype<br>Blood (15-3-1999) 93, 1942-1950. PubMed  Europe PubMed
    20. 1998
  20. Huang,C., Sali,A. and Stevens,R.L.<br>Regulation and function of mast cell proteases in inflammation<br>J Clin Immunol (1998) 18, 169-183. PubMed  Europe PubMed DOI
  21. [YEAR:15-7-1998]Shiota,N., Fukamizu,A., Okunishi,H., Takai,S., Murakami,K. and Miyazaki,M.<br>Cloning of the gene and cDNA for hamster chymase 2, and expression of chymase 1, chymase 2 and angiotensin-converting enzyme in the terminal stage of cardiomyopathic hearts<br>Biochem J (15-7-1998) 333, 417-424. PubMed  Europe PubMed  PMC  EPMC
    22. 1997
  22. Lutzelschwab,C., Pejler,G., Aveskogh,M. and Hellman,L.<br>Secretory granule proteases in rat mast cells. Cloning of 10 different serine proteases and a carboxypeptidase A from various rat mast cell populations<br>J Exp Med (1997) 185, 13-29. PubMed  Europe PubMed DOI  PMC  EPMC
  23. Morii,E., Jippo,T., Tsujimura,T., Hashimoto,K., Kim,D.K., Lee,Y.M., Ogihara,H., Tsujino,K., Kim,H.M. and Kitamura,Y.<br>Abnormal expression of mouse mast cell protease 5 gene in cultured mast cells derived from mutant mi/mi mice<br>Blood (1997) 90, 3057-3066. PubMed  Europe PubMed
    24. 1995
  24. Springman,E.B. and Serafin,W.E.<br>Structure, genetics, and regulation of expression of secretory endo- and exopeptidases of mouse mast cells<br>Clin Allergy Immunol (1995) 6, 169-201.
    25. 1994
  25. Huang,R. and Hellman,L.<br>Genes for mast-cell serine protease and their molecular evolution<br>Immunogenetics (1994) 40, 397-414. PubMed  Europe PubMed
    26. 1993
  26. Gurish,M.F., Nadeau,J.H., Johnson,K.R., McNeil,H.P., Grattan,K.M., Austen,K.F. and Stevens,R.L.<br>A closely linked complex of mouse mast cell-specific chymase genes on chromosome 14<br>J Biol Chem (1993) 268, 11372-11379. PubMed  Europe PubMed
  27. [YEAR:25-4-1993]Sali,A., Matsumoto,R., McNeil,H.P., Karplus,M. and Stevens,R.L.<br>Three-dimensional models of four mouse mast cell chymases. Identification of proteoglycan binding regions and protease-specific antigenic epitopes<br>J Biol Chem (25-4-1993) 268, 9023-9034. PubMed  Europe PubMed
    28. 1992
  28. Chu,W., Johnson,D.A. and Musich,P.R.<br>Molecular cloning and characterization of mouse mast cell chymases<br>Biochim Biophys Acta (1992) 1121, 83-87. PubMed  Europe PubMed DOI
    29. 1991
  29. Huang,R.Y., Blom,T. and Hellman,L.<br>Cloning and structural analysis of MMCP-1, MMCP-4 and MMCP-5, three mouse mast cell-specific serine proteases<br>Eur J Immunol (1991) 21, 1611-1621. PubMed  Europe PubMed DOI
  30. McNeil,H.P., Austen,K.F., Somerville,L.L., Gurish,M.F. and Stevens,R.L.<br>Molecular cloning of the mouse mast cell protease-5 gene. A novel secretory granule protease expressed early in the differentiation of serosal mast cells<br>J Biol Chem (1991) 266, 20316-20322. PubMed  Europe PubMed
    31. 1990
  31. Reynolds,D.S., Stevens,R.L., Lane,W.S., Carr,M.H., Austen,K.F. and Serafin,W.E.<br>Different mouse mast cell populations express various combinations of at least six distinct mast cell serine proteases<br>Proc Natl Acad Sci U S A (1990) 87, 3230-3234. PubMed  Europe PubMed  PMC  EPMC

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2025 EBI
Terms of use