$VAR1 = undef;

Summary for peptidase S01.141: mast cell peptidase 1 (Rattus-type)

Names
MEROPS Name	mast cell peptidase 1 (Rattus-type)
Other names	rat mast cell protease 2, rMCP-2, chymase 2 (Rattus norvegicus)

Domain architecture

MEROPS Classification
Classification	Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.141
Holotype	mast cell peptidase 1 (Rattus-type) (Rattus norvegicus), Uniprot accession P00770 (peptidase unit: 21-246), MERNUM MER0000126
History	Identifier created: MEROPS 3.02 (25 June 1998)

Activity
Catalytic type	Serine
Peplist	Included in the Peplist with identifier PL00276
NC-IUBMB	Not yet included in IUBMB recommendations.
Knockout	In mice, disruption of the gene led to profound histochemical and ultrastructural changes in intestinal mucosal mast cell granules (Wastling et al., 1998).
Pharmaceutical relevance	Chymase inhibitors showed promise for the prevention of post-operative adhesions in a hamster model (Okamoto et al., 2004; Soga et al., 2004). Also, a chymase inhibitor prevented the development of abdominal aortic aneurysm in a hamster experimental model (Tsunemi et al., 2004).
Other databases	TREEFAM	http://www.treefam.org/family/TF333630