Substrates for peptidase S01.141: mast cell peptidase 1 (Rattus-type)

Summary Gene structure Alignment Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
endothelin-1 precursor	P22388	26-202	peptide-Phe66+Cys-peptide	P		Cys	Val	Tyr	Phe	Cys	His	Leu	Asp	Nakano et al., 1997
endothelin-1 precursor	P22388	26-202	peptide-Tyr83+Gly-peptide	P		Val	Val	Pro	Tyr	Gly	Leu	Gly	Ser	Nakano et al., 1997
endothelin-1 precursor	P22388	53-73	peptide-Tyr65+Phe-peptide	P		Glu	Cys	Val	Tyr	Phe	Cys	His	Leu	Nakano et al., 1997
endothelin-1 precursor	P22388	26-202	peptide-Trp73+Val-peptide	P		Asp	Ile	Ile	Trp	Val	Asn	Thr	Pro	Nakano et al., 1997
Prothrombin	P00735	44-625	Peptide-Phe332+Gly-Peptide	N	NT	Glu	Lys	Thr	Phe	Gly	Ala	Gly	Glu	Pejler et al., 1995
Prothrombin	P00735	44-625	Peptide-Trp514+Thr-Peptide	N	NT	Arg	Glu	Thr	Trp	Thr	Thr	Ser	Val	Pejler et al., 1995
Prothrombin	P00735	44-625	Peptide-Tyr480+Ile-Peptide	N	NT	Leu	Ser	Asp	Tyr	Ile	His	Pro	Val	Pejler et al., 1995