$VAR1 = undef;

Summary for peptidase S01.135: granzyme A

Names
MEROPS Name	granzyme A
Other names	CTLA3, GZMA g.p. (Homo sapiens), HuTSP, T-cell associated protease 1, T-cell specific proteinase 1, TSP-1

Domain architecture

MEROPS Classification
Classification	Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.135
Holotype	granzyme A (Homo sapiens), Uniprot accession P12544 (peptidase unit: 29-261), MERNUM MER0001379
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Serine
Peplist	Included in the Peplist with identifier PL00273
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.78
Enzymology	BRENDA database
Proteolytic events	CutDB database (8 cleavages)
Activity status	human: active (Froelich, 2004) mouse: active (Odake et al., 1991)
Knockout	Granzyme A-deficient mice retain potent cell-mediated cytotoxicity (Ebnet et al., 1995).
Pathways	KEGG	Neuroactive ligand-receptor interaction
Other databases	TREEFAM	http://www.treefam.org/family/TF333630
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/-/-/RKa/gl/-/- (based on 441 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	28	46	19	5	29	99	59	33
Pro	44	4	67	4	0	2	17	11
Ala	57	58	30	11	134	60	36	49
Val	39	40	15	4	22	11	15	35
Leu	39	13	51	13	9	88	40	51
Ile	47	19	4	0	11	20	26	35
Met	8	16	6	0	4	17	7	3
Phe	3	3	19	2	1	11	23	4
Tyr	5	15	33	2	8	6	2	12
Trp	1	0	4	0	0	0	0	0
Ser	20	65	64	0	59	27	43	19
Thr	38	20	28	15	36	10	17	14
Cys	2	4	10	1	3	3	2	2
Asn	5	10	15	0	12	4	10	18
Gln	5	23	7	0	18	26	33	24
Asp	7	26	27	1	12	11	14	14
Glu	21	32	12	1	10	33	32	45
Lys	21	25	11	129	52	7	53	57
Arg	35	18	13	253	0	0	2	0
His	8	2	4	0	17	0	4	8