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Literature for peptidase S01.135: granzyme A

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, K Knockout, P Specificity, E Expression, V Review, I Inhibitor, R Splicing, L Localization. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Maleka,M.N., Mbita,Z. and Morafo,V.<br>Regulation of Granzymes A and B by High-Risk HPV: Impact on Immune Evasion and Carcinogenesis<br>Viruses (2025) 17 PubMed  Europe PubMed DOI  PMC  EPMC  V
  2. Malespini,S.M., Kazim,M. and Yoo,E.<br>Development of Granzyme a Turn-ON Fluorescent Activity-Based Probes<br>Chembiochem (2025) , e202500771-e202500771. PubMed  Europe PubMed DOI
    3. 2024
  3. Quinn,J.P., Fisher,K., Corbett,N., Warwood,S., Knight,D., Kellett,K.A.B. and Hooper,N.M.<br>Proteolysis of tau by granzyme A in tauopathies generates fragments that are aggregation prone<br>Biochem J (2024) 481, 1255-1274. PubMed  Europe PubMed DOI
    4. 2023
  4. Kumagai,J., Kiuchi,M., Kokubo,K., Yagyu,H., Nemoto,M., Tsuji,K., Nagahata,K., Sasaki,A., Hishiya,T., Onoue,M., Shinmi,R., Sonobe,Y., Iinuma,T., Yonekura,S., Shinga,J., Hanazawa,T., Koseki,H., Nakayama,T., Yokote,K. and Hirahara,K.<br>The USP7-STAT3-granzyme-Par-1 axis regulates allergic inflammation by promoting differentiation of IL-5-producing Th2 cells<br>Proc Natl Acad Sci U S A (2023) 120, e2302903120-e2302903120. PubMed  Europe PubMed DOI  PMC  EPMC
  5. Rasi,V., Phelps,K.R., Paulson,K.R., Eickhoff,C.S., Chinnaraj,M., Pozzi,N., Di Gioia,M., Zanoni,I., Shakya,S., Carlson,H.L., Ford,D.A., Kolar,G.R. and Hoft,D.F.<br>Homodimeric Granzyme A opsonizes Mycobacterium tuberculosis and inhibits its intracellular growth in human monocytes via TLR4 and CD14<br>J Infect Dis (2023) PubMed  Europe PubMed DOI
    6. 2020
  6. Kolt,S., Janiszewski,T., Kaiserman,D., Modrzycka,S., Snipas,S.J., Salvesen,G., Dra G,M., Bird,P.I. and Kasperkiewicz,P.<br>Detection of active granzyme A in NK92 cells with fluorescent activity-based probe<br>J Med Chem (2020) 63, 3359-3369. PubMed  Europe PubMed DOI  L
  7. Prunk,M., Perisic Nanut,M., Jakos,T., Sabotic,J., Svajger,U. and Kos,J.<br>Extracellular Cystatin F Is Internalised by Cytotoxic T Lymphocytes and Decreases Their Cytotoxicity<br>Cancers (Basel) (2020) 12 PubMed  Europe PubMed DOI  PMC  EPMC
  8. Zhou,Z., He,H., Wang,K., Shi,X., Wang,Y., Su,Y., Wang,Y., Li,D., Liu,W., Zhang,Y., Shen,L., Han,W., Shen,L., Ding,J. and Shao,F.<br>Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells<br>Science (2020) 368, eaaz7548-eaaz7548. PubMed  Europe PubMed DOI
    9. 2019
  9. Chaves-Pozo,E., Valero,Y., Lozano,M.T., Rodriguez-Cerezo,P., Miao,L., Campo,V., Esteban,M.A. and Cuesta,A.<br>Fish granzyme A shows a greater role than granzyme B in fish innate cell-mediated cytotoxicity<br>Front Immunol (2019) 10, 2579-2579. PubMed  Europe PubMed DOI  PMC  EPMC
  10. Schanoski,A.S., Le,T.T., Kaiserman,D., Rowe,C., Prow,N.A., Barboza,D.D., Santos,C.A., Zanotto,P.M.A., Magalhaes,K.G., Aurelio,L., Muller,D., Young,P., Zhao,P., Bird,P.I. and Suhrbier,A.<br>Granzyme A in Chikungunya and other arboviral infections<br>Front Immunol (2019) 10, 3083-3083. PubMed  Europe PubMed DOI  PMC  EPMC
    11. 2018
  11. Campbell,R.A., Franks,Z., Bhatnagar,A., Rowley,J.W., Manne,B.K., Supiano,M.A., Schwertz,H., Weyrich,A.S. and Rondina,M.T.<br>Granzyme A in human platelets regulates the synthesis of proinflammatory cytokines by monocytes in aging<br>J Immunol (2018) 200, 295-304. PubMed  Europe PubMed DOI
    12. 2017
  12. van Eck,J.A., Shan,L., Meeldijk,J., Hack,C.E. and Bovenschen,N.<br>A novel proinflammatory role for granzyme A<br>Cell Death Dis (2017) 8, e2630-e2630. PubMed  Europe PubMed DOI
    13. 2016
  13. Lee,P.Y., Park,B.C., Chi,S.W., Bae,K.H., Kim,S., Cho,S., Kang,S., Kim,J.H. and Park,S.G.<br>Histone H4 is cleaved by granzyme A during staurosporine-induced cell death in B-lymphoid Raji cells<br>BMB Rep (2016) 49, 560-565. PubMed  Europe PubMed
  14. Uranga,S., Marinova,D., Martin,C., Pardo,J. and Aguilo,N.<br>Granzyme A is expressed in mouse lungs during Mycobacterium tuberculosis infection but does not contribute to protection in vivo<br>PLoS ONE (2016) 11, e0153028-e0153028. PubMed  Europe PubMed DOI
  15. Wensink,A.C., Kok,H.M., Meeldijk,J., Fermie,J., Froelich,C.J., Hack,C.E. and Bovenschen,N.<br>Granzymes A and K differentially potentiate LPS-induced cytokine response<br>Cell Death Discov (2016) 2, 16084-16084. PubMed  Europe PubMed DOI  PMC  EPMC
    16. 2015
  16. Dotiwala,F., Fellay,I., Filgueira,L., Martinvalet,D., Lieberman,J. and Walch,M.<br>A high yield and cost-efficient expression system of human granzymes in mammalian cells<br>J Vis Exp (2015) , e52911-e52911. PubMed  Europe PubMed DOI  E
  17. Lee,P.Y., Park,B.C., Chi,S.W., Bae,K.H., Kim,S., Cho,S., Kim,J.H. and Park,S.G.<br>Histone H3 is digested by granzyme A during compromised cell death in the Raji cells<br>J Microbiol Biotechnol (2015) 25, 1578-1582. PubMed  Europe PubMed DOI  I
  18. Niehaus,J.Z., Miedel,M.T., Good,M., Wyatt,A.N., Pak,S.C., Silverman,G.A. and Luke,C.J.<br>SERPINB12 is a slow-binding inhibitor of granzyme A and hepsin<br>Biochemistry (2015) 54, 6756-6759. PubMed  Europe PubMed DOI
  19. Velaga,S., Ukena,S.N., Dringenberg,U., Alter,C., Pardo,J., Kershaw,O. and Franzke,A.<br>Granzyme A is required for regulatory T-cell mediated prevention of gastrointestinal graft-versus-host disease<br>PLoS ONE (2015) 10, e0124927- PubMed  Europe PubMed DOI  PMC  EPMC
    20. 2014
  20. Ahmad,J., Bird,P.I. and Kaiserman,D.<br>Analysis of the evolution of granule associated serine proteases of immune defence (GASPIDs) suggests a revised nomenclature<br>Biol Chem (2014) 395, 1253-1262. PubMed  Europe PubMed DOI
  21. Kaiserman,D., Stewart,S.E., Plasman,K., Gevaert,K., Van Damme,P. and Bird,P.I.<br>Identification of Serpinb6b as a species-specific mouse granzyme A inhibitor suggests functional divergence between human and mouse granzyme A<br>J Biol Chem (2014) 289, 9408-9417. PubMed  Europe PubMed DOI
  22. Plasman,K., Maurer-Stroh,S., Gevaert,K. and Van Damme,P.<br>Holistic view on the extended substrate specificities of orthologous granzymes<br>J Proteome Res (2014) 13, 1785-1793. PubMed  Europe PubMed DOI  P
  23. Plasman,K., Demol,H., Bird,P.I., Gevaert,K. and Van Damme,P.<br>Substrate specificities of the granzyme tryptases A and K<br>J Proteome Res (2014) 13, 6067-6077. PubMed  Europe PubMed DOI  P
  24. Vahedi,F., Fraleigh,N., Vlasschaert,C., McElhaney,J. and Hanifi-Moghaddam,P.<br>Human granzymes: related but far apart<br>Med Hypotheses (2014) 83, 688-693. PubMed  Europe PubMed DOI  V
    25. 2013
  25. Susanto,O., Stewart,S.E., Voskoboinik,I., Brasacchio,D., Hagn,M., Ellis,S., Asquith,S., Sedelies,K.A., Bird,P.I., Waterhouse,N.J. and Trapani,J.A.<br>Mouse granzyme A induces a novel death with writhing morphology that is mechanistically distinct from granzyme B-induced apoptosis<br>Cell Death Differ (2013) 20, 1183-1193. PubMed  Europe PubMed DOI
    26. 2012
  26. Du,J.N., Chen,L., Long,F.Y. and Jiang,W.Z.<br>Cloning and prokaryotic expression of full-length gene of human granzyme A<br>Chin J Biol (2012) 25, 168-170+175.  E
  27. Froelich,C.J.<br>Granzyme A<br>[ISSN:978-0-12-407742-3] (2012) 3, 2715-2718. DOI
    28. 2010
  28. Lieberman,J.<br>Granzyme A activates another way to die<br>Immunol Rev (2010) 235, 93-104. PubMed  Europe PubMed DOI  V
  29. Van Damme,P., Maurer-Stroh,S., Hao,H., Colaert,N., Timmerman,E., Eisenhaber,F., Vandekerckhove,J. and Gevaert,K.<br>The substrate specificity profile of human granzyme A<br>Biol Chem (2010) 391, 983-997. PubMed  Europe PubMed DOI  P
    30. 2009
  30. Froelich,C.J., Pardo,J. and Simon,M.M.<br>Granule-associated serine proteases: granzymes might not just be killer proteases<br>Trends Immunol (2009) 30, 117-123. PubMed  Europe PubMed DOI  V
  31. Martinvalet,D., Walch,M., Jensen,D.K., Thiery,J. and Lieberman,J.<br>Response: Granzyme A: cell death-inducing protease, proinflammatory agent, or both?<br>Blood (2009) 114, 3969-3970. DOI
  32. Pardo,J., Simon,M.M. and Froelich,C.J.<br>Granzyme A is a proinflammatory protease<br>Blood (2009) 114, 3969-3969. PubMed  Europe PubMed DOI
  33. Zhu,P., Martinvalet,D., Chowdhury,D., Zhang,D., Schlesinger,A. and Lieberman,J.<br>The cytotoxic T lymphocyte protease granzyme A cleaves and inactivates poly(adenosine 5'-diphosphate-ribose) polymerase-1<br>Blood (2009) 114, 1205-1216. PubMed  Europe PubMed DOI  PMC  EPMC
    34. 2008
  34. Chowdhury,D. and Lieberman,J.<br>Death by a thousand cuts: granzyme pathways of programmed cell death<br>Annu Rev Immunol (2008) 26, 389-420. PubMed  Europe PubMed DOI  V
  35. Hirayasu,H., Yoshikawa,Y., Tsuzuki,S. and Fushiki,T.<br>A lymphocyte serine protease granzyme A causes detachment of a small-intestinal epithelial cell line (IEC-6)<br>Biosci Biotechnol Biochem (2008) 72, 2294-2302. PubMed  Europe PubMed DOI
  36. Lucken-Ardjomande,S. and Martinou,J.C.<br>Granzyme A, a stealth killer in the mitochondrion<br>Cell (2008) 133, 568-570. PubMed  Europe PubMed DOI
  37. Martinvalet,D., Dykxhoorn,D.M., Ferrini,R. and Lieberman,J.<br>Granzyme A cleaves a mitochondrial complex I protein to initiate caspase-independent cell death<br>Cell (2008) 133, 681-692. PubMed  Europe PubMed DOI
    38. 2007
  38. Hirayasu,H., Yoshikawa,Y., Tsuzuki,S. and Fushiki,T.<br>A role of a lymphocyte tryptase, granzyme A, in experimental ulcerative colitis<br>Biosci Biotechnol Biochem (2007) 71, 234-237. PubMed  Europe PubMed DOI
  39. Lee-Kirsch,M.A., Chowdhury,D., Harvey,S., Gong,M., Senenko,L., Engel,K., Pfeiffer,C., Hollis,T., Gahr,M., Perrino,F.W., Lieberman,J. and Hubner,N.<br>A mutation in TREX1 that impairs susceptibility to granzyme A-mediated cell death underlies familial chilblain lupus<br>J Mol Med (Berl) (2007) 85, 531-537. PubMed  Europe PubMed DOI
    40. 2006
  40. Zhu,P., Zhang,D., Chowdhury,D., Martinvalet,D., Keefe,D., Shi,L. and Lieberman,J.<br>Granzyme A, which causes single-stranded DNA damage, targets the double-strand break repair protein Ku70<br>EMBO Rep (2006) 7, 431-437. PubMed  Europe PubMed DOI  PMC  EPMC
    41. 2005
  41. Mahrus,S. and Craik,C.S.<br>Selective chemical functional probes of granzymes A and B reveal granzyme B is a major effector of natural killer cell-mediated lysis of target cells<br>Chem Biol (2005) 12, 567-577. PubMed  Europe PubMed DOI
  42. Martinvalet,D., Zhu,P. and Lieberman,J.<br>Granzyme A induces caspase-independent mitochondrial damage, a required first step for apoptosis<br>Immunity (2005) 22, 355-370. PubMed  Europe PubMed DOI
    43. 2004
  43. Froelich,C.J.<br>Granzyme A<br>[ISSN:0-12-079610-4] (2004) 2, 1547-1549.  V
  44. [YEAR:8-11-2004]Pardo,J., Bosque,A., Brehm,R., Wallich,R., Naval,J., Mullbacher,A., Anel,A. and Simon,M.M.<br>Apoptotic pathways are selectively activated by granzyme A and/or granzyme B in CTL-mediated target cell lysis<br>J Cell Biol (8-11-2004) 167, 457-468. PubMed  Europe PubMed DOI  PMC  EPMC
    45. 2003
  45. Bell,J.K., Goetz,D.H., Mahrus,S., Harris,J.L., Fletterick,R.J. and Craik,C.S.<br>The oligomeric structure of human granzyme A is a determinant of its extended substrate specificity<br>Nat Struct Biol (2003) 10, 527-534. PubMed  Europe PubMed DOI  S
  46. Fan,Z., Beresford,P.J., Zhang,D., Xu,Z., Novina,C.D., Yoshida,A., Pommier,Y. and Lieberman,J.<br>Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A<br>Nat Immunol (2003) 4, 145-153. PubMed  Europe PubMed DOI  P
  47. Hink-Schauer,C., Estebanez-Perpina,E., Kurschus,F.C., Bode,W. and Jenne,D.E.<br>Crystal structure of the apoptosis-inducing human granzyme A dimer<br>Nat Struct Biol (2003) 10, 535-540. PubMed  Europe PubMed DOI  S
  48. Lieberman,J. and Fan,Z.<br>Nuclear war: the granzyme A-bomb<br>Curr Opin Immunol (2003) 15, 553-559. PubMed  Europe PubMed DOI
  49. [YEAR:5-9-2003]Sattar,R., Ali,S.A. and Abbasi,A.<br>Bioinformatics of granzymes: sequence comparison and structural studies on granzyme family by homology modeling<br>Biochem Biophys Res Commun (5-9-2003) 308, 726-735. PubMed  Europe PubMed DOI
  50. [YEAR:15-7-2003]Smyth,M.J., Street,S.E. and Trapani,J.A.<br>Cutting edge: granzymes A and B are not essential for perforin-mediated tumor rejection<br>J Immunol (15-7-2003) 171, 515-518. PubMed  Europe PubMed
  51. [YEAR:15-5-2003]Tsuzuki,S., Kokado,Y., Satomi,S., Yamasaki,Y., Hirayasu,H., Iwanaga,T. and Fushiki,T.<br>Purification and identification of a binding protein for pancreatic secretory trypsin inhibitor: a novel role of the inhibitor as an anti-granzyme A<br>Biochem J (15-5-2003) 372, 227-233. PubMed  Europe PubMed DOI  PMC  EPMC
  52. Yamada,M., Hirasawa,A., Shiojima,S. and Tsujimoto,G.<br>Granzyme A mediates glucocorticoid-induced apoptosis in leukemia cells<br>FASEB J (2003) 17, 1712-1714. PubMed  Europe PubMed DOI
    53. 2001
  53. [YEAR:16-11-2001]Beresford,P.J., Zhang,D., Oh,D.Y., Fan,Z., Greer,E.L., Russo,M.L., Jaju,M. and Lieberman,J.<br>Granzyme A activates an endoplasmic reticulum-associated caspase-independent nuclease to induce single-stranded DNA nicks<br>J Biol Chem (16-11-2001) 276, 43285-43293. PubMed  Europe PubMed DOI
  54. Davis,J.E., Smyth,M.J. and Trapani,J.A.<br>Granzyme A and B-deficient killer lymphocytes are defective in eliciting DNA fragmentation but retain potent in vivo anti-tumor capacity<br>Eur J Immunol (2001) 31, 39-47. PubMed  Europe PubMed DOI
  55. [YEAR:8-5-2001]Zhang,D., Beresford,P.J., Greenberg,A.H. and Lieberman,J.<br>Granzymes A and B directly cleave lamins and disrupt the nuclear lamina during granule-mediated cytolysis<br>Proc Natl Acad Sci U S A (8-5-2001) 98, 5746-5751. PubMed  Europe PubMed DOI  PMC  EPMC
    56. 2000
  56. Pereira,R.A., Simon,M.M. and Simmons,A.<br>Granzyme A, a noncytolytic component of CD8(+) cell granules, restricts the spread of herpes simplex virus in the peripheral nervous systems of experimentally infected mice<br>J Virol (2000) 74, 1029-1032. PubMed  Europe PubMed DOI  PMC  EPMC
  57. [YEAR:15-2-2000]Spaeny-Dekking,E.H., Kamp,A.M., Froelich,C.J. and Hack,C.E.<br>Extracellular granzyme A, complexed to proteoglycans, is protected against inactivation by protease inhibitors<br>Blood (15-2-2000) 95, 1465-1472. PubMed  Europe PubMed
    58. 1999
  58. Blink,E.J., Trapani,J.A. and Jans,D.A.<br>Perforin-dependent nuclear targeting of granzymes: A central role in the nuclear events of granule-exocytosis-mediated apoptosis?<br>Immunol Cell Biol (1999) 77, 206-215. PubMed  Europe PubMed DOI
  59. [YEAR:23-11-1999]Mullbacher,A., Waring,P., Tha Hla,R., Tran,T., Chin,S., Stehle,T., Museteanu,C. and Simon,M.M.<br>Granzymes are the essential downstream effector molecules for the control of primary virus infections by cytolytic leukocytes<br>Proc Natl Acad Sci U S A (23-11-1999) 96, 13950-13955. PubMed  Europe PubMed DOI  PMC  EPMC
    60. 1998
  60. Jans,D.A., Briggs,L.J., Jans,P., Froelich,C.J., Parasivam,G., Kumar,S., Sutton,V.R. and Trapani,J.A.<br>Nuclear targeting of the serine protease granzyme A (fragmentin-1)<br>J Cell Sci (1998) 111, 2645-2654. PubMed  Europe PubMed
  61. [YEAR:15-6-1998]Mabee,C.L., McGuire,M.J. and Thiele,D.L.<br>Dipeptidyl peptidase I and granzyme A are coordinately expressed during CD8+ T cell development and differentiation<br>J Immunol (15-6-1998) 160, 5880-5885. PubMed  Europe PubMed
  62. [YEAR:1-12-1998]Presnell,S.R., Patil,G.S., Mura,C., Jude,K.M., Conley,J.M., Bertrand,J.A., Kam,C.M., Powers,J.C. and Williams,L.D.<br>Oxyanion-mediated inhibition of serine proteases<br>Biochemistry (1-12-1998) 37, 17068-17081. PubMed  Europe PubMed DOI  S  I
  63. [YEAR:1-4-1998]Spaeny-Dekking,E.H., Hanna,W.L., Wolbink,A.M., Wever,P.C., Kummer,A.J., Swaak,A.J., Middeldorp,J.M., Huisman,H.G., Froelich,C.J. and Hack,C.E.<br>Extracellular granzymes A and B in humans: detection of native species during CTL responses in vitro and in vivo<br>J Immunol (1-4-1998) 160, 3610-3616. PubMed  Europe PubMed
    64. 1997
  64. Beresford,P.J., Kam,C.M., Powers,J.C. and Lieberman,J.<br>Recombinant human granzyme A binds to two putative HLA-associated proteins and cleaves one of them<br>Proc Natl Acad Sci U S A (1997) 94, 9285-9290. PubMed  Europe PubMed DOI  PMC  EPMC
  65. Kato,Y., Yokochi,T., Sasaki,K., Kawamoto,Y., Tsuji,T. and Miyama,A.<br>The major component of Na-CBZ-L-lysine thiobenzyl ester (BLT)-specific proteases in cytoplasmic granules of murine intraepithelial lymphocytes is granzyme A<br>Immunobiology (1997) 196, 465-474.  I
    66. 1996
  66. Koo,G.C., Luk,Y., Talento,A., Wu,J., Sirotina,A., Fischer,P.A., Blake,J.T., Nguyen,M.P., Parsons,W. and Poe,M.<br>Association of serine protease with the rise of intracellular calcium in cytotoxic T lymphocytes<br>Cell Immunol (1996) 174, 107-115. PubMed  Europe PubMed DOI
  67. Kummer,J.A., Kamp,A.M., Citarella,F., Horrevoets,A.J. and Hack,C.E.<br>Expression of human recombinant granzyme A zymogen and its activation by the cysteine proteinase cathepsin C<br>J Biol Chem (1996) 271, 9281-9286. PubMed  Europe PubMed DOI
  68. Mullbacher,A., Ebnet,K., Blanden,R.V., Hla,R.T., Stehle,T., Museteanu,C. and Simon,M.M.<br>Granzyme A is critical for recovery of mice from infection with the natural cytopathic viral pathogen, ectromelia<br>Proc Natl Acad Sci U S A (1996) 93, 5783-5787. PubMed  Europe PubMed DOI  PMC  EPMC
  69. Smyth,M.J., O'Connor,M.D. and Trapani,J.A.<br>Granzymes: a variety of serine protease specificities encoded by genetically distinct subfamilies<br>J Leukoc Biol (1996) 60, 555-562. PubMed  Europe PubMed  V
    70. 1995
  70. Ebnet,K., Hausmann,M., Lehmann-Grube,F., Mullbacher,A., Kopf,M., Lamers,M. and Simon,M.M.<br>Granzyme A-deficient mice retain potent cell-mediated cytotoxicity<br>EMBO J (1995) 14, 4230-4239. PubMed  Europe PubMed  PMC  EPMC  K
  71. Irmler,M., Hertig,S., MacDonald,H.R., Sadoul,R., Becherer,J.D., Proudfoot,A., Solari,R. and Tschopp,J.<br>Granzyme A is an interleukin 1beta-converting enzyme<br>J Exp Med (1995) 181, 1917-1922. PubMed  Europe PubMed  PMC  EPMC
    72. 1994
  72. Simon,M.M. and Kramer,M.D.<br>Granzyme A<br>Methods Enzymol (1994) 244, 68-79. PubMed  Europe PubMed DOI  V
    73. 1993
  73. Fink,T.M., Lichter,P., Wekerle,H., Zimmer,M. and Jenne,D.E.<br>The human granzyme A (HFSP, CTLA3) gene maps to 5q11-q12 and defines a new locus of the serine protease superfamily<br>Genomics (1993) 18, 401-403. PubMed  Europe PubMed DOI
  74. Hanna,W.L., Zhang,X., Turbov,J., Winkler,U., Hudig,D. and Froelich,C.J.<br>Rapid purification of cationic granule proteases: application to human granzymes<br>Protein Expr Purif (1993) 4, 398-404. PubMed  Europe PubMed DOI
  75. [YEAR:6-7-1993]Kummer,J.A., Kamp,A.M., van Katwijk,M., Brakenhoff,J.P., Radosevic,K., van Leeuwen,A.M., Borst,J., Verweij,C.L. and Hack,C.E.<br>Production and characterization of monoclonal antibodies raised against recombinant human granzymes A and B and showing cross reactions with the natural proteins<br>J Immunol Methods (6-7-1993) 163, 77-83. PubMed  Europe PubMed DOI
  76. Nakamura,K., Arahata,K., Ishiura,S., Osame,M. and Sugita,H.<br>Degradative activity of granzyme A on skeletal muscle proteins in vitro: a possible molecular mechanism for muscle fiber damage in polymyositis<br>Neuromuscul Disord (1993) 3, 303-310. PubMed  Europe PubMed DOI
    77. 1992
  77. Hershberger,R.J., Gershenfeld,H.K., Weissman,I.L. and Su,L.<br>Genomic organization of the mouse granzyme A gene. Two mRNAs encode the same mature granzyme A with different leader peptides<br>J Biol Chem (1992) 267, 25488-25493. PubMed  Europe PubMed  R
  78. Talento,A., Nguyen,M., Law,S., Wu,J.K., Poe,M., Blake,J.T., Patel,M., Wu,T.J., Manyak,C.L., Silberklang,M., Mark,G., Springer,M., Sigal,N.H., Weissman,I.L., Bleackley,R.C., Podack,E.R., Tykocinski,M.L. and Koo,G.C.<br>Transfection of mouse cytotoxic T lymphocyte with an antisense granzyme A vector reduces lytic activity<br>J Immunol (1992) 149, 4009-4015. PubMed  Europe PubMed  K
    79. 1991
  79. Odake,S., Kam,C.M., Narasimhan,L., Poe,M., Blake,J.T., Krahenbuhl,O., Tschopp,J. and Powers,J.C.<br>Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins<br>Biochemistry (1991) 30, 2217-2227. PubMed  Europe PubMed  I
  80. Simon,M.M., Kramer,M.D., Prester,M. and Gay,S.<br>Mouse T-cell associated serine proteinase 1 degrades collagen type IV: A structural basis for the migration of lymphocytes through vascular basement membranes<br>Immunology (1991) 73, 117-119. PubMed  Europe PubMed  PMC  EPMC
    81. 1990
  81. Simon,M.M., Tran,T., Fruth,U., Gurwitz,D. and Kramer,M.D.<br>Regulation of mouse T cell associated serine proteinase-1 (MTSP- 1) by proteinase inhibitors and sulfated polysaccharides<br>Biol Chem Hoppe Seyler (1990) 371 Suppl, 81-87. PubMed  Europe PubMed
    82. 1988
  82. Gershenfeld,H.K., Hershberger,R.J., Shows,T.B. and Weissman,I.L.<br>Cloning and chromosomal assignment of a human cDNA encoding a T cell- and natural killer cell-specific trypsin-like serine protease<br>Proc Natl Acad Sci U S A (1988) 85, 1184-1188. PubMed  Europe PubMed  PMC  EPMC
  83. [YEAR:15-9-1988]Poe,M., Bennett,C.D., Biddison,W.E., Blake,J.T., Norton,G.P., Rodkey,J.A., Sigal,N.H., Turner,R.V., Wu,J.K. and Zweerink,H.J.<br>Human cytotoxic lymphocyte tryptase. Its purification from granules and the characterization of inhibitor and substrate specificity<br>J Biol Chem (15-9-1988) 263, 13215-13222. PubMed  Europe PubMed
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