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Literature for peptidase S01.135: granzyme A

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, K Knockout, P Specificity, E Expression, V Review, I Inhibitor, R Splicing, L Localization. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Maleka,M.N., Mbita,Z. and Morafo,V.
    Regulation of Granzymes A and B by High-Risk HPV: Impact on Immune Evasion and Carcinogenesis
    Viruses17, PubMed  Europe PubMed DOI  V
    2. 2024
  2. Quinn,J.P., Fisher,K., Corbett,N., Warwood,S., Knight,D., Kellett,K.A.B. and Hooper,N.M.
    Proteolysis of tau by granzyme A in tauopathies generates fragments that are aggregation prone
    Biochem J481, 1255-1274. PubMed  Europe PubMed DOI
    3. 2023
  3. Kumagai,J., Kiuchi,M., Kokubo,K., Yagyu,H., Nemoto,M., Tsuji,K., Nagahata,K., Sasaki,A., Hishiya,T., Onoue,M., Shinmi,R., Sonobe,Y., Iinuma,T., Yonekura,S., Shinga,J., Hanazawa,T., Koseki,H., Nakayama,T., Yokote,K. and Hirahara,K.
    The USP7-STAT3-granzyme-Par-1 axis regulates allergic inflammation by promoting differentiation of IL-5-producing Th2 cells
    Proc Natl Acad Sci U S A120, e2302903120-e2302903120. PubMed  Europe PubMed DOI
  4. Rasi,V., Phelps,K.R., Paulson,K.R., Eickhoff,C.S., Chinnaraj,M., Pozzi,N., Di Gioia,M., Zanoni,I., Shakya,S., Carlson,H.L., Ford,D.A., Kolar,G.R. and Hoft,D.F.
    Homodimeric Granzyme A opsonizes Mycobacterium tuberculosis and inhibits its intracellular growth in human monocytes via TLR4 and CD14
    J Infect Dis PubMed  Europe PubMed DOI
    5. 2020
  5. Kolt,S., Janiszewski,T., Kaiserman,D., Modrzycka,S., Snipas,S.J., Salvesen,G., Dra G,M., Bird,P.I. and Kasperkiewicz,P.
    Detection of active granzyme A in NK92 cells with fluorescent activity-based probe
    J Med Chem63, 3359-3369. PubMed  Europe PubMed DOI  L
  6. Prunk,M., Perisic Nanut,M., Jakos,T., Sabotic,J., Svajger,U. and Kos,J.
    Extracellular Cystatin F Is Internalised by Cytotoxic T Lymphocytes and Decreases Their Cytotoxicity
    Cancers (Basel)12, PubMed  Europe PubMed DOI
  7. Zhou,Z., He,H., Wang,K., Shi,X., Wang,Y., Su,Y., Wang,Y., Li,D., Liu,W., Zhang,Y., Shen,L., Han,W., Shen,L., Ding,J. and Shao,F.
    Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells
    Science368, eaaz7548-eaaz7548. PubMed  Europe PubMed DOI
    8. 2019
  8. Chaves-Pozo,E., Valero,Y., Lozano,M.T., Rodriguez-Cerezo,P., Miao,L., Campo,V., Esteban,M.A. and Cuesta,A.
    Fish granzyme A shows a greater role than granzyme B in fish innate cell-mediated cytotoxicity
    Front Immunol10, 2579-2579. PubMed  Europe PubMed DOI
  9. Schanoski,A.S., Le,T.T., Kaiserman,D., Rowe,C., Prow,N.A., Barboza,D.D., Santos,C.A., Zanotto,P.M.A., Magalhaes,K.G., Aurelio,L., Muller,D., Young,P., Zhao,P., Bird,P.I. and Suhrbier,A.
    Granzyme A in Chikungunya and other arboviral infections
    Front Immunol10, 3083-3083. PubMed  Europe PubMed DOI
    10. 2018
  10. Campbell,R.A., Franks,Z., Bhatnagar,A., Rowley,J.W., Manne,B.K., Supiano,M.A., Schwertz,H., Weyrich,A.S. and Rondina,M.T.
    Granzyme A in human platelets regulates the synthesis of proinflammatory cytokines by monocytes in aging
    J Immunol200, 295-304. PubMed  Europe PubMed DOI
    11. 2017
  11. van Eck,J.A., Shan,L., Meeldijk,J., Hack,C.E. and Bovenschen,N.
    A novel proinflammatory role for granzyme A
    Cell Death Dis8, e2630-e2630. PubMed  Europe PubMed DOI
    12. 2016
  12. Lee,P.Y., Park,B.C., Chi,S.W., Bae,K.H., Kim,S., Cho,S., Kang,S., Kim,J.H. and Park,S.G.
    Histone H4 is cleaved by granzyme A during staurosporine-induced cell death in B-lymphoid Raji cells
    BMB Rep49, 560-565. PubMed  Europe PubMed
  13. Uranga,S., Marinova,D., Martin,C., Pardo,J. and Aguilo,N.
    Granzyme A is expressed in mouse lungs during Mycobacterium tuberculosis infection but does not contribute to protection in vivo
    PLoS ONE11, e0153028-e0153028. PubMed  Europe PubMed DOI
  14. Wensink,A.C., Kok,H.M., Meeldijk,J., Fermie,J., Froelich,C.J., Hack,C.E. and Bovenschen,N.
    Granzymes A and K differentially potentiate LPS-induced cytokine response
    Cell Death Discov2, 16084-16084. PubMed  Europe PubMed DOI
    15. 2015
  15. Dotiwala,F., Fellay,I., Filgueira,L., Martinvalet,D., Lieberman,J. and Walch,M.
    A high yield and cost-efficient expression system of human granzymes in mammalian cells
    J Vis Expe52911-e52911. PubMed  Europe PubMed DOI  E
  16. Lee,P.Y., Park,B.C., Chi,S.W., Bae,K.H., Kim,S., Cho,S., Kim,J.H. and Park,S.G.
    Histone H3 is digested by granzyme A during compromised cell death in the Raji cells
    J Microbiol Biotechnol25, 1578-1582. PubMed  Europe PubMed DOI  I
  17. Niehaus,J.Z., Miedel,M.T., Good,M., Wyatt,A.N., Pak,S.C., Silverman,G.A. and Luke,C.J.
    SERPINB12 is a slow-binding inhibitor of granzyme A and hepsin
    Biochemistry54, 6756-6759. PubMed  Europe PubMed DOI
  18. Velaga,S., Ukena,S.N., Dringenberg,U., Alter,C., Pardo,J., Kershaw,O. and Franzke,A.
    Granzyme A is required for regulatory T-cell mediated prevention of gastrointestinal graft-versus-host disease
    PLoS ONE10, e0124927- PubMed  Europe PubMed DOI
    19. 2014
  19. Ahmad,J., Bird,P.I. and Kaiserman,D.
    Analysis of the evolution of granule associated serine proteases of immune defence (GASPIDs) suggests a revised nomenclature
    Biol Chem395, 1253-1262. PubMed  Europe PubMed DOI
  20. Kaiserman,D., Stewart,S.E., Plasman,K., Gevaert,K., Van Damme,P. and Bird,P.I.
    Identification of Serpinb6b as a species-specific mouse granzyme A inhibitor suggests functional divergence between human and mouse granzyme A
    J Biol Chem289, 9408-9417. PubMed  Europe PubMed DOI
  21. Plasman,K., Demol,H., Bird,P.I., Gevaert,K. and Van Damme,P.
    Substrate specificities of the granzyme tryptases A and K
    J Proteome Res13, 6067-6077. PubMed  Europe PubMed DOI  P
  22. Plasman,K., Maurer-Stroh,S., Gevaert,K. and Van Damme,P.
    Holistic view on the extended substrate specificities of orthologous granzymes
    J Proteome Res13, 1785-1793. PubMed  Europe PubMed DOI  P
  23. Vahedi,F., Fraleigh,N., Vlasschaert,C., McElhaney,J. and Hanifi-Moghaddam,P.
    Human granzymes: related but far apart
    Med Hypotheses83, 688-693. PubMed  Europe PubMed DOI  V
    24. 2013
  24. Susanto,O., Stewart,S.E., Voskoboinik,I., Brasacchio,D., Hagn,M., Ellis,S., Asquith,S., Sedelies,K.A., Bird,P.I., Waterhouse,N.J. and Trapani,J.A.
    Mouse granzyme A induces a novel death with writhing morphology that is mechanistically distinct from granzyme B-induced apoptosis
    Cell Death Differ20, 1183-1193. PubMed  Europe PubMed DOI
    25. 2012
  25. Du,J.N., Chen,L., Long,F.Y. and Jiang,W.Z.
    Cloning and prokaryotic expression of full-length gene of human granzyme A
    Chin J Biol25, 168-170+175.  E
  26. Froelich,C.J.
    Granzyme A
    [ISSN:978-0-12-407742-3]3, 2715-2718. DOI
    27. 2010
  27. Lieberman,J.
    Granzyme A activates another way to die
    Immunol Rev235, 93-104. PubMed  Europe PubMed DOI  V
  28. Van Damme,P., Maurer-Stroh,S., Hao,H., Colaert,N., Timmerman,E., Eisenhaber,F., Vandekerckhove,J. and Gevaert,K.
    The substrate specificity profile of human granzyme A
    Biol Chem391, 983-997. PubMed  Europe PubMed DOI  P
    29. 2009
  29. Froelich,C.J., Pardo,J. and Simon,M.M.
    Granule-associated serine proteases: granzymes might not just be killer proteases
    Trends Immunol30, 117-123. PubMed  Europe PubMed DOI  V
  30. Martinvalet,D., Walch,M., Jensen,D.K., Thiery,J. and Lieberman,J.
    Response: Granzyme A: cell death-inducing protease, proinflammatory agent, or both?
    Blood114, 3969-3970. DOI
  31. Pardo,J., Simon,M.M. and Froelich,C.J.
    Granzyme A is a proinflammatory protease
    Blood114, 3969-3969. PubMed  Europe PubMed DOI
  32. Zhu,P., Martinvalet,D., Chowdhury,D., Zhang,D., Schlesinger,A. and Lieberman,J.
    The cytotoxic T lymphocyte protease granzyme A cleaves and inactivates poly(adenosine 5'-diphosphate-ribose) polymerase-1
    Blood114, 1205-1216. PubMed  Europe PubMed DOI
    33. 2008
  33. Chowdhury,D. and Lieberman,J.
    Death by a thousand cuts: granzyme pathways of programmed cell death
    Annu Rev Immunol26, 389-420. PubMed  Europe PubMed DOI  V
  34. Hirayasu,H., Yoshikawa,Y., Tsuzuki,S. and Fushiki,T.
    A lymphocyte serine protease granzyme A causes detachment of a small-intestinal epithelial cell line (IEC-6)
    Biosci Biotechnol Biochem72, 2294-2302. PubMed  Europe PubMed DOI
  35. Lucken-Ardjomande,S. and Martinou,J.C.
    Granzyme A, a stealth killer in the mitochondrion
    Cell133, 568-570. PubMed  Europe PubMed DOI
  36. Martinvalet,D., Dykxhoorn,D.M., Ferrini,R. and Lieberman,J.
    Granzyme A cleaves a mitochondrial complex I protein to initiate caspase-independent cell death
    Cell133, 681-692. PubMed  Europe PubMed DOI
    37. 2007
  37. Hirayasu,H., Yoshikawa,Y., Tsuzuki,S. and Fushiki,T.
    A role of a lymphocyte tryptase, granzyme A, in experimental ulcerative colitis
    Biosci Biotechnol Biochem71, 234-237. PubMed  Europe PubMed DOI
  38. Lee-Kirsch,M.A., Chowdhury,D., Harvey,S., Gong,M., Senenko,L., Engel,K., Pfeiffer,C., Hollis,T., Gahr,M., Perrino,F.W., Lieberman,J. and Hubner,N.
    A mutation in TREX1 that impairs susceptibility to granzyme A-mediated cell death underlies familial chilblain lupus
    J Mol Med (Berl)85, 531-537. PubMed  Europe PubMed DOI
    39. 2006
  39. Zhu,P., Zhang,D., Chowdhury,D., Martinvalet,D., Keefe,D., Shi,L. and Lieberman,J.
    Granzyme A, which causes single-stranded DNA damage, targets the double-strand break repair protein Ku70
    EMBO Rep7, 431-437. PubMed  Europe PubMed DOI
    40. 2005
  40. Mahrus,S. and Craik,C.S.
    Selective chemical functional probes of granzymes A and B reveal granzyme B is a major effector of natural killer cell-mediated lysis of target cells
    Chem Biol12, 567-577. PubMed  Europe PubMed DOI
  41. Martinvalet,D., Zhu,P. and Lieberman,J.
    Granzyme A induces caspase-independent mitochondrial damage, a required first step for apoptosis
    Immunity22, 355-370. PubMed  Europe PubMed DOI
    42. 2004
  42. Froelich,C.J.
    Granzyme A
    [ISSN:0-12-079610-4]2, 1547-1549.  V
  43. [YEAR:8-11-2004]Pardo,J., Bosque,A., Brehm,R., Wallich,R., Naval,J., Mullbacher,A., Anel,A. and Simon,M.M.
    Apoptotic pathways are selectively activated by granzyme A and/or granzyme B in CTL-mediated target cell lysis
    J Cell Biol167, 457-468. PubMed  Europe PubMed DOI
    44. 2003
  44. Bell,J.K., Goetz,D.H., Mahrus,S., Harris,J.L., Fletterick,R.J. and Craik,C.S.
    The oligomeric structure of human granzyme A is a determinant of its extended substrate specificity
    Nat Struct Biol10, 527-534. PubMed  Europe PubMed DOI  S
  45. Fan,Z., Beresford,P.J., Zhang,D., Xu,Z., Novina,C.D., Yoshida,A., Pommier,Y. and Lieberman,J.
    Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A
    Nat Immunol4, 145-153. PubMed  Europe PubMed DOI  P
  46. Hink-Schauer,C., Estebanez-Perpina,E., Kurschus,F.C., Bode,W. and Jenne,D.E.
    Crystal structure of the apoptosis-inducing human granzyme A dimer
    Nat Struct Biol10, 535-540. PubMed  Europe PubMed DOI  S
  47. Lieberman,J. and Fan,Z.
    Nuclear war: the granzyme A-bomb
    Curr Opin Immunol15, 553-559. PubMed  Europe PubMed DOI
  48. [YEAR:5-9-2003]Sattar,R., Ali,S.A. and Abbasi,A.
    Bioinformatics of granzymes: sequence comparison and structural studies on granzyme family by homology modeling
    Biochem Biophys Res Commun308, 726-735. PubMed  Europe PubMed DOI
  49. [YEAR:15-7-2003]Smyth,M.J., Street,S.E. and Trapani,J.A.
    Cutting edge: granzymes A and B are not essential for perforin-mediated tumor rejection
    J Immunol171, 515-518. PubMed  Europe PubMed
  50. [YEAR:15-5-2003]Tsuzuki,S., Kokado,Y., Satomi,S., Yamasaki,Y., Hirayasu,H., Iwanaga,T. and Fushiki,T.
    Purification and identification of a binding protein for pancreatic secretory trypsin inhibitor: a novel role of the inhibitor as an anti-granzyme A
    Biochem J372, 227-233. PubMed  Europe PubMed DOI
  51. Yamada,M., Hirasawa,A., Shiojima,S. and Tsujimoto,G.
    Granzyme A mediates glucocorticoid-induced apoptosis in leukemia cells
    FASEB J17, 1712-1714. PubMed  Europe PubMed DOI
    52. 2001
  52. [YEAR:16-11-2001]Beresford,P.J., Zhang,D., Oh,D.Y., Fan,Z., Greer,E.L., Russo,M.L., Jaju,M. and Lieberman,J.
    Granzyme A activates an endoplasmic reticulum-associated caspase-independent nuclease to induce single-stranded DNA nicks
    J Biol Chem276, 43285-43293. PubMed  Europe PubMed DOI
  53. Davis,J.E., Smyth,M.J. and Trapani,J.A.
    Granzyme A and B-deficient killer lymphocytes are defective in eliciting DNA fragmentation but retain potent in vivo anti-tumor capacity
    Eur J Immunol31, 39-47. PubMed  Europe PubMed DOI
  54. [YEAR:8-5-2001]Zhang,D., Beresford,P.J., Greenberg,A.H. and Lieberman,J.
    Granzymes A and B directly cleave lamins and disrupt the nuclear lamina during granule-mediated cytolysis
    Proc Natl Acad Sci U S A98, 5746-5751. PubMed  Europe PubMed DOI
    55. 2000
  55. Pereira,R.A., Simon,M.M. and Simmons,A.
    Granzyme A, a noncytolytic component of CD8(+) cell granules, restricts the spread of herpes simplex virus in the peripheral nervous systems of experimentally infected mice
    J Virol74, 1029-1032. PubMed  Europe PubMed DOI
  56. [YEAR:15-2-2000]Spaeny-Dekking,E.H., Kamp,A.M., Froelich,C.J. and Hack,C.E.
    Extracellular granzyme A, complexed to proteoglycans, is protected against inactivation by protease inhibitors
    Blood95, 1465-1472. PubMed  Europe PubMed
    57. 1999
  57. Blink,E.J., Trapani,J.A. and Jans,D.A.
    Perforin-dependent nuclear targeting of granzymes: A central role in the nuclear events of granule-exocytosis-mediated apoptosis?
    Immunol Cell Biol77, 206-215. PubMed  Europe PubMed DOI
  58. [YEAR:23-11-1999]Mullbacher,A., Waring,P., Tha Hla,R., Tran,T., Chin,S., Stehle,T., Museteanu,C. and Simon,M.M.
    Granzymes are the essential downstream effector molecules for the control of primary virus infections by cytolytic leukocytes
    Proc Natl Acad Sci U S A96, 13950-13955. PubMed  Europe PubMed DOI
    59. 1998
  59. Jans,D.A., Briggs,L.J., Jans,P., Froelich,C.J., Parasivam,G., Kumar,S., Sutton,V.R. and Trapani,J.A.
    Nuclear targeting of the serine protease granzyme A (fragmentin-1)
    J Cell Sci111, 2645-2654. PubMed  Europe PubMed
  60. [YEAR:15-6-1998]Mabee,C.L., McGuire,M.J. and Thiele,D.L.
    Dipeptidyl peptidase I and granzyme A are coordinately expressed during CD8+ T cell development and differentiation
    J Immunol160, 5880-5885. PubMed  Europe PubMed
  61. [YEAR:1-12-1998]Presnell,S.R., Patil,G.S., Mura,C., Jude,K.M., Conley,J.M., Bertrand,J.A., Kam,C.M., Powers,J.C. and Williams,L.D.
    Oxyanion-mediated inhibition of serine proteases
    Biochemistry37, 17068-17081. PubMed  Europe PubMed DOI  S  I
  62. [YEAR:1-4-1998]Spaeny-Dekking,E.H., Hanna,W.L., Wolbink,A.M., Wever,P.C., Kummer,A.J., Swaak,A.J., Middeldorp,J.M., Huisman,H.G., Froelich,C.J. and Hack,C.E.
    Extracellular granzymes A and B in humans: detection of native species during CTL responses in vitro and in vivo
    J Immunol160, 3610-3616. PubMed  Europe PubMed
    63. 1997
  63. Beresford,P.J., Kam,C.M., Powers,J.C. and Lieberman,J.
    Recombinant human granzyme A binds to two putative HLA-associated proteins and cleaves one of them
    Proc Natl Acad Sci U S A94, 9285-9290. PubMed  Europe PubMed DOI
  64. Kato,Y., Yokochi,T., Sasaki,K., Kawamoto,Y., Tsuji,T. and Miyama,A.
    The major component of Na-CBZ-L-lysine thiobenzyl ester (BLT)-specific proteases in cytoplasmic granules of murine intraepithelial lymphocytes is granzyme A
    Immunobiology196, 465-474.  I
    65. 1996
  65. Koo,G.C., Luk,Y., Talento,A., Wu,J., Sirotina,A., Fischer,P.A., Blake,J.T., Nguyen,M.P., Parsons,W. and Poe,M.
    Association of serine protease with the rise of intracellular calcium in cytotoxic T lymphocytes
    Cell Immunol174, 107-115. PubMed  Europe PubMed DOI
  66. Kummer,J.A., Kamp,A.M., Citarella,F., Horrevoets,A.J. and Hack,C.E.
    Expression of human recombinant granzyme A zymogen and its activation by the cysteine proteinase cathepsin C
    J Biol Chem271, 9281-9286. PubMed  Europe PubMed DOI
  67. Mullbacher,A., Ebnet,K., Blanden,R.V., Hla,R.T., Stehle,T., Museteanu,C. and Simon,M.M.
    Granzyme A is critical for recovery of mice from infection with the natural cytopathic viral pathogen, ectromelia
    Proc Natl Acad Sci U S A93, 5783-5787. PubMed  Europe PubMed DOI
  68. Smyth,M.J., O'Connor,M.D. and Trapani,J.A.
    Granzymes: a variety of serine protease specificities encoded by genetically distinct subfamilies
    J Leukoc Biol60, 555-562. PubMed  Europe PubMed  V
    69. 1995
  69. Ebnet,K., Hausmann,M., Lehmann-Grube,F., Mullbacher,A., Kopf,M., Lamers,M. and Simon,M.M.
    Granzyme A-deficient mice retain potent cell-mediated cytotoxicity
    EMBO J14, 4230-4239. PubMed  Europe PubMed  K
  70. Irmler,M., Hertig,S., MacDonald,H.R., Sadoul,R., Becherer,J.D., Proudfoot,A., Solari,R. and Tschopp,J.
    Granzyme A is an interleukin 1beta-converting enzyme
    J Exp Med181, 1917-1922. PubMed  Europe PubMed
    71. 1994
  71. Simon,M.M. and Kramer,M.D.
    Granzyme A
    Methods Enzymol244, 68-79. PubMed  Europe PubMed DOI  V
    72. 1993
  72. Fink,T.M., Lichter,P., Wekerle,H., Zimmer,M. and Jenne,D.E.
    The human granzyme A (HFSP, CTLA3) gene maps to 5q11-q12 and defines a new locus of the serine protease superfamily
    Genomics18, 401-403. PubMed  Europe PubMed DOI
  73. Hanna,W.L., Zhang,X., Turbov,J., Winkler,U., Hudig,D. and Froelich,C.J.
    Rapid purification of cationic granule proteases: application to human granzymes
    Protein Expr Purif4, 398-404. PubMed  Europe PubMed DOI
  74. [YEAR:6-7-1993]Kummer,J.A., Kamp,A.M., van Katwijk,M., Brakenhoff,J.P., Radosevic,K., van Leeuwen,A.M., Borst,J., Verweij,C.L. and Hack,C.E.
    Production and characterization of monoclonal antibodies raised against recombinant human granzymes A and B and showing cross reactions with the natural proteins
    J Immunol Methods163, 77-83. PubMed  Europe PubMed DOI
  75. Nakamura,K., Arahata,K., Ishiura,S., Osame,M. and Sugita,H.
    Degradative activity of granzyme A on skeletal muscle proteins in vitro: a possible molecular mechanism for muscle fiber damage in polymyositis
    Neuromuscul Disord3, 303-310. PubMed  Europe PubMed DOI
    76. 1992
  76. Hershberger,R.J., Gershenfeld,H.K., Weissman,I.L. and Su,L.
    Genomic organization of the mouse granzyme A gene. Two mRNAs encode the same mature granzyme A with different leader peptides
    J Biol Chem267, 25488-25493. PubMed  Europe PubMed  R
  77. Talento,A., Nguyen,M., Law,S., Wu,J.K., Poe,M., Blake,J.T., Patel,M., Wu,T.J., Manyak,C.L., Silberklang,M., Mark,G., Springer,M., Sigal,N.H., Weissman,I.L., Bleackley,R.C., Podack,E.R., Tykocinski,M.L. and Koo,G.C.
    Transfection of mouse cytotoxic T lymphocyte with an antisense granzyme A vector reduces lytic activity
    J Immunol149, 4009-4015. PubMed  Europe PubMed  K
    78. 1991
  78. Odake,S., Kam,C.M., Narasimhan,L., Poe,M., Blake,J.T., Krahenbuhl,O., Tschopp,J. and Powers,J.C.
    Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins
    Biochemistry30, 2217-2227. PubMed  Europe PubMed  I
  79. Simon,M.M., Kramer,M.D., Prester,M. and Gay,S.
    Mouse T-cell associated serine proteinase 1 degrades collagen type IV: A structural basis for the migration of lymphocytes through vascular basement membranes
    Immunology73, 117-119. PubMed  Europe PubMed
    80. 1990
  80. Simon,M.M., Tran,T., Fruth,U., Gurwitz,D. and Kramer,M.D.
    Regulation of mouse T cell associated serine proteinase-1 (MTSP- 1) by proteinase inhibitors and sulfated polysaccharides
    Biol Chem Hoppe Seyler371 Suppl, 81-87. PubMed  Europe PubMed
    81. 1988
  81. Gershenfeld,H.K., Hershberger,R.J., Shows,T.B. and Weissman,I.L.
    Cloning and chromosomal assignment of a human cDNA encoding a T cell- and natural killer cell-specific trypsin-like serine protease
    Proc Natl Acad Sci U S A85, 1184-1188. PubMed  Europe PubMed
  82. [YEAR:15-9-1988]Poe,M., Bennett,C.D., Biddison,W.E., Blake,J.T., Norton,G.P., Rodkey,J.A., Sigal,N.H., Turner,R.V., Wu,J.K. and Zweerink,H.J.
    Human cytotoxic lymphocyte tryptase. Its purification from granules and the characterization of inhibitor and substrate specificity
    J Biol Chem263, 13215-13222. PubMed  Europe PubMed
  83. Simon,H.G., Fruth,U., Eckerskorn,C., Lottspeich,F., Kramer,M.D., Nerz,G. and Simon,M.M.
    Induction of T cell serine proteinase 1 (TSP-1)-specific mRNA in mouse T lymphocytes
    Eur J Immunol18, 855-861. PubMed  Europe PubMed DOI
  84. Simon,M.M., Prester,M., Nerz,G., Kramer,M.D. and Fruth,U.
    Release of biologically active fragments from human plasma-fibronectin by murine T cell-specific proteinase 1 (TSP-1)
    Biol Chem Hoppe Seyler369 Suppl, 107-112. PubMed  Europe PubMed
    85. 1987
  85. Fruth,U., Sinigaglia,F., Schlesier,M., Kilgus,J., Kramer,M.D. and Simon,M.M.
    A novel serine proteinase (HuTSP) isolated from a cloned human CD8+ cytolytic T cell line is expressed and secreted by activated CD4+ and CD8+ lymphocytes
    Eur J Immunol17, 1625-1633. PubMed  Europe PubMed DOI
    86. 1986
  86. Masson,D., Zamai,M. and Tschopp,J.
    Identification of granzyme A isolated from cytotoxic T-lymphocyte-granules as one of the proteases encoded by CTL-specific genes
    FEBS Lett208, 84-88. PubMed  Europe PubMed
  87. Simon,M.M., Hoschutzky,H., Fruth,U., Simon,H.G. and Kramer,M.D.
    Purification and characterization of a T cell specific serine proteinase (TSP-1) from cloned cytolytic T lymphocytes
    EMBO J5, 3267-3274. PubMed  Europe PubMed

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