Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Literature for peptidase S01.135: granzyme A

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, K Knockout, P Specificity, E Expression, V Review, I Inhibitor, R Splicing, L Localization. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Maleka,M.N., Mbita,Z. and Morafo,V.
    Regulation of Granzymes A and B by High-Risk HPV: Impact on Immune Evasion and Carcinogenesis
    Viruses (2025) 17 PubMed  Europe PubMed DOI  PMC  EPMC  V
  2. Malespini,S.M., Kazim,M. and Yoo,E.
    Development of Granzyme a Turn-ON Fluorescent Activity-Based Probes
    Chembiochem (2025) , e202500771-e202500771. PubMed  Europe PubMed DOI
    3. 2024
  3. Quinn,J.P., Fisher,K., Corbett,N., Warwood,S., Knight,D., Kellett,K.A.B. and Hooper,N.M.
    Proteolysis of tau by granzyme A in tauopathies generates fragments that are aggregation prone
    Biochem J (2024) 481, 1255-1274. PubMed  Europe PubMed DOI
    4. 2023
  4. Kumagai,J., Kiuchi,M., Kokubo,K., Yagyu,H., Nemoto,M., Tsuji,K., Nagahata,K., Sasaki,A., Hishiya,T., Onoue,M., Shinmi,R., Sonobe,Y., Iinuma,T., Yonekura,S., Shinga,J., Hanazawa,T., Koseki,H., Nakayama,T., Yokote,K. and Hirahara,K.
    The USP7-STAT3-granzyme-Par-1 axis regulates allergic inflammation by promoting differentiation of IL-5-producing Th2 cells
    Proc Natl Acad Sci U S A (2023) 120, e2302903120-e2302903120. PubMed  Europe PubMed DOI  PMC  EPMC
  5. Rasi,V., Phelps,K.R., Paulson,K.R., Eickhoff,C.S., Chinnaraj,M., Pozzi,N., Di Gioia,M., Zanoni,I., Shakya,S., Carlson,H.L., Ford,D.A., Kolar,G.R. and Hoft,D.F.
    Homodimeric Granzyme A opsonizes Mycobacterium tuberculosis and inhibits its intracellular growth in human monocytes via TLR4 and CD14
    J Infect Dis (2023) PubMed  Europe PubMed DOI
    6. 2020
  6. Kolt,S., Janiszewski,T., Kaiserman,D., Modrzycka,S., Snipas,S.J., Salvesen,G., Dra G,M., Bird,P.I. and Kasperkiewicz,P.
    Detection of active granzyme A in NK92 cells with fluorescent activity-based probe
    J Med Chem (2020) 63, 3359-3369. PubMed  Europe PubMed DOI  L
  7. Prunk,M., Perisic Nanut,M., Jakos,T., Sabotic,J., Svajger,U. and Kos,J.
    Extracellular Cystatin F Is Internalised by Cytotoxic T Lymphocytes and Decreases Their Cytotoxicity
    Cancers (Basel) (2020) 12 PubMed  Europe PubMed DOI  PMC  EPMC
  8. Zhou,Z., He,H., Wang,K., Shi,X., Wang,Y., Su,Y., Wang,Y., Li,D., Liu,W., Zhang,Y., Shen,L., Han,W., Shen,L., Ding,J. and Shao,F.
    Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells
    Science (2020) 368, eaaz7548-eaaz7548. PubMed  Europe PubMed DOI
    9. 2019
  9. Chaves-Pozo,E., Valero,Y., Lozano,M.T., Rodriguez-Cerezo,P., Miao,L., Campo,V., Esteban,M.A. and Cuesta,A.
    Fish granzyme A shows a greater role than granzyme B in fish innate cell-mediated cytotoxicity
    Front Immunol (2019) 10, 2579-2579. PubMed  Europe PubMed DOI  PMC  EPMC
  10. Schanoski,A.S., Le,T.T., Kaiserman,D., Rowe,C., Prow,N.A., Barboza,D.D., Santos,C.A., Zanotto,P.M.A., Magalhaes,K.G., Aurelio,L., Muller,D., Young,P., Zhao,P., Bird,P.I. and Suhrbier,A.
    Granzyme A in Chikungunya and other arboviral infections
    Front Immunol (2019) 10, 3083-3083. PubMed  Europe PubMed DOI  PMC  EPMC
    11. 2018
  11. Campbell,R.A., Franks,Z., Bhatnagar,A., Rowley,J.W., Manne,B.K., Supiano,M.A., Schwertz,H., Weyrich,A.S. and Rondina,M.T.
    Granzyme A in human platelets regulates the synthesis of proinflammatory cytokines by monocytes in aging
    J Immunol (2018) 200, 295-304. PubMed  Europe PubMed DOI
    12. 2017
  12. van Eck,J.A., Shan,L., Meeldijk,J., Hack,C.E. and Bovenschen,N.
    A novel proinflammatory role for granzyme A
    Cell Death Dis (2017) 8, e2630-e2630. PubMed  Europe PubMed DOI
    13. 2016
  13. Lee,P.Y., Park,B.C., Chi,S.W., Bae,K.H., Kim,S., Cho,S., Kang,S., Kim,J.H. and Park,S.G.
    Histone H4 is cleaved by granzyme A during staurosporine-induced cell death in B-lymphoid Raji cells
    BMB Rep (2016) 49, 560-565. PubMed  Europe PubMed
  14. Uranga,S., Marinova,D., Martin,C., Pardo,J. and Aguilo,N.
    Granzyme A is expressed in mouse lungs during Mycobacterium tuberculosis infection but does not contribute to protection in vivo
    PLoS ONE (2016) 11, e0153028-e0153028. PubMed  Europe PubMed DOI
  15. Wensink,A.C., Kok,H.M., Meeldijk,J., Fermie,J., Froelich,C.J., Hack,C.E. and Bovenschen,N.
    Granzymes A and K differentially potentiate LPS-induced cytokine response
    Cell Death Discov (2016) 2, 16084-16084. PubMed  Europe PubMed DOI  PMC  EPMC
    16. 2015
  16. Dotiwala,F., Fellay,I., Filgueira,L., Martinvalet,D., Lieberman,J. and Walch,M.
    A high yield and cost-efficient expression system of human granzymes in mammalian cells
    J Vis Exp (2015) , e52911-e52911. PubMed  Europe PubMed DOI  E
  17. Lee,P.Y., Park,B.C., Chi,S.W., Bae,K.H., Kim,S., Cho,S., Kim,J.H. and Park,S.G.
    Histone H3 is digested by granzyme A during compromised cell death in the Raji cells
    J Microbiol Biotechnol (2015) 25, 1578-1582. PubMed  Europe PubMed DOI  I
  18. Niehaus,J.Z., Miedel,M.T., Good,M., Wyatt,A.N., Pak,S.C., Silverman,G.A. and Luke,C.J.
    SERPINB12 is a slow-binding inhibitor of granzyme A and hepsin
    Biochemistry (2015) 54, 6756-6759. PubMed  Europe PubMed DOI
  19. Velaga,S., Ukena,S.N., Dringenberg,U., Alter,C., Pardo,J., Kershaw,O. and Franzke,A.
    Granzyme A is required for regulatory T-cell mediated prevention of gastrointestinal graft-versus-host disease
    PLoS ONE (2015) 10, e0124927- PubMed  Europe PubMed DOI  PMC  EPMC
    20. 2014
  20. Ahmad,J., Bird,P.I. and Kaiserman,D.
    Analysis of the evolution of granule associated serine proteases of immune defence (GASPIDs) suggests a revised nomenclature
    Biol Chem (2014) 395, 1253-1262. PubMed  Europe PubMed DOI
  21. Kaiserman,D., Stewart,S.E., Plasman,K., Gevaert,K., Van Damme,P. and Bird,P.I.
    Identification of Serpinb6b as a species-specific mouse granzyme A inhibitor suggests functional divergence between human and mouse granzyme A
    J Biol Chem (2014) 289, 9408-9417. PubMed  Europe PubMed DOI
  22. Plasman,K., Maurer-Stroh,S., Gevaert,K. and Van Damme,P.
    Holistic view on the extended substrate specificities of orthologous granzymes
    J Proteome Res (2014) 13, 1785-1793. PubMed  Europe PubMed DOI  P
  23. Plasman,K., Demol,H., Bird,P.I., Gevaert,K. and Van Damme,P.
    Substrate specificities of the granzyme tryptases A and K
    J Proteome Res (2014) 13, 6067-6077. PubMed  Europe PubMed DOI  P
  24. Vahedi,F., Fraleigh,N., Vlasschaert,C., McElhaney,J. and Hanifi-Moghaddam,P.
    Human granzymes: related but far apart
    Med Hypotheses (2014) 83, 688-693. PubMed  Europe PubMed DOI  V
    25. 2013
  25. Susanto,O., Stewart,S.E., Voskoboinik,I., Brasacchio,D., Hagn,M., Ellis,S., Asquith,S., Sedelies,K.A., Bird,P.I., Waterhouse,N.J. and Trapani,J.A.
    Mouse granzyme A induces a novel death with writhing morphology that is mechanistically distinct from granzyme B-induced apoptosis
    Cell Death Differ (2013) 20, 1183-1193. PubMed  Europe PubMed DOI
    26. 2012
  26. Du,J.N., Chen,L., Long,F.Y. and Jiang,W.Z.
    Cloning and prokaryotic expression of full-length gene of human granzyme A
    Chin J Biol (2012) 25, 168-170+175.  E
  27. Froelich,C.J.
    Granzyme A
    [ISSN:978-0-12-407742-3] (2012) 3, 2715-2718. DOI
    28. 2010
  28. Lieberman,J.
    Granzyme A activates another way to die
    Immunol Rev (2010) 235, 93-104. PubMed  Europe PubMed DOI  V
  29. Van Damme,P., Maurer-Stroh,S., Hao,H., Colaert,N., Timmerman,E., Eisenhaber,F., Vandekerckhove,J. and Gevaert,K.
    The substrate specificity profile of human granzyme A
    Biol Chem (2010) 391, 983-997. PubMed  Europe PubMed DOI  P
    30. 2009
  30. Froelich,C.J., Pardo,J. and Simon,M.M.
    Granule-associated serine proteases: granzymes might not just be killer proteases
    Trends Immunol (2009) 30, 117-123. PubMed  Europe PubMed DOI  V
  31. Martinvalet,D., Walch,M., Jensen,D.K., Thiery,J. and Lieberman,J.
    Response: Granzyme A: cell death-inducing protease, proinflammatory agent, or both?
    Blood (2009) 114, 3969-3970. DOI
  32. Pardo,J., Simon,M.M. and Froelich,C.J.
    Granzyme A is a proinflammatory protease
    Blood (2009) 114, 3969-3969. PubMed  Europe PubMed DOI
  33. Zhu,P., Martinvalet,D., Chowdhury,D., Zhang,D., Schlesinger,A. and Lieberman,J.
    The cytotoxic T lymphocyte protease granzyme A cleaves and inactivates poly(adenosine 5'-diphosphate-ribose) polymerase-1
    Blood (2009) 114, 1205-1216. PubMed  Europe PubMed DOI  PMC  EPMC
    34. 2008
  34. Chowdhury,D. and Lieberman,J.
    Death by a thousand cuts: granzyme pathways of programmed cell death
    Annu Rev Immunol (2008) 26, 389-420. PubMed  Europe PubMed DOI  V
  35. Hirayasu,H., Yoshikawa,Y., Tsuzuki,S. and Fushiki,T.
    A lymphocyte serine protease granzyme A causes detachment of a small-intestinal epithelial cell line (IEC-6)
    Biosci Biotechnol Biochem (2008) 72, 2294-2302. PubMed  Europe PubMed DOI
  36. Lucken-Ardjomande,S. and Martinou,J.C.
    Granzyme A, a stealth killer in the mitochondrion
    Cell (2008) 133, 568-570. PubMed  Europe PubMed DOI
  37. Martinvalet,D., Dykxhoorn,D.M., Ferrini,R. and Lieberman,J.
    Granzyme A cleaves a mitochondrial complex I protein to initiate caspase-independent cell death
    Cell (2008) 133, 681-692. PubMed  Europe PubMed DOI
    38. 2007
  38. Hirayasu,H., Yoshikawa,Y., Tsuzuki,S. and Fushiki,T.
    A role of a lymphocyte tryptase, granzyme A, in experimental ulcerative colitis
    Biosci Biotechnol Biochem (2007) 71, 234-237. PubMed  Europe PubMed DOI
  39. Lee-Kirsch,M.A., Chowdhury,D., Harvey,S., Gong,M., Senenko,L., Engel,K., Pfeiffer,C., Hollis,T., Gahr,M., Perrino,F.W., Lieberman,J. and Hubner,N.
    A mutation in TREX1 that impairs susceptibility to granzyme A-mediated cell death underlies familial chilblain lupus
    J Mol Med (Berl) (2007) 85, 531-537. PubMed  Europe PubMed DOI
    40. 2006
  40. Zhu,P., Zhang,D., Chowdhury,D., Martinvalet,D., Keefe,D., Shi,L. and Lieberman,J.
    Granzyme A, which causes single-stranded DNA damage, targets the double-strand break repair protein Ku70
    EMBO Rep (2006) 7, 431-437. PubMed  Europe PubMed DOI  PMC  EPMC
    41. 2005
  41. Mahrus,S. and Craik,C.S.
    Selective chemical functional probes of granzymes A and B reveal granzyme B is a major effector of natural killer cell-mediated lysis of target cells
    Chem Biol (2005) 12, 567-577. PubMed  Europe PubMed DOI
  42. Martinvalet,D., Zhu,P. and Lieberman,J.
    Granzyme A induces caspase-independent mitochondrial damage, a required first step for apoptosis
    Immunity (2005) 22, 355-370. PubMed  Europe PubMed DOI
    43. 2004
  43. Froelich,C.J.
    Granzyme A
    [ISSN:0-12-079610-4] (2004) 2, 1547-1549.  V
  44. [YEAR:8-11-2004]Pardo,J., Bosque,A., Brehm,R., Wallich,R., Naval,J., Mullbacher,A., Anel,A. and Simon,M.M.
    Apoptotic pathways are selectively activated by granzyme A and/or granzyme B in CTL-mediated target cell lysis
    J Cell Biol (8-11-2004) 167, 457-468. PubMed  Europe PubMed DOI  PMC  EPMC
    45. 2003
  45. Bell,J.K., Goetz,D.H., Mahrus,S., Harris,J.L., Fletterick,R.J. and Craik,C.S.
    The oligomeric structure of human granzyme A is a determinant of its extended substrate specificity
    Nat Struct Biol (2003) 10, 527-534. PubMed  Europe PubMed DOI  S
  46. Fan,Z., Beresford,P.J., Zhang,D., Xu,Z., Novina,C.D., Yoshida,A., Pommier,Y. and Lieberman,J.
    Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A
    Nat Immunol (2003) 4, 145-153. PubMed  Europe PubMed DOI  P
  47. Hink-Schauer,C., Estebanez-Perpina,E., Kurschus,F.C., Bode,W. and Jenne,D.E.
    Crystal structure of the apoptosis-inducing human granzyme A dimer
    Nat Struct Biol (2003) 10, 535-540. PubMed  Europe PubMed DOI  S
  48. Lieberman,J. and Fan,Z.
    Nuclear war: the granzyme A-bomb
    Curr Opin Immunol (2003) 15, 553-559. PubMed  Europe PubMed DOI
  49. [YEAR:5-9-2003]Sattar,R., Ali,S.A. and Abbasi,A.
    Bioinformatics of granzymes: sequence comparison and structural studies on granzyme family by homology modeling
    Biochem Biophys Res Commun (5-9-2003) 308, 726-735. PubMed  Europe PubMed DOI
  50. [YEAR:15-7-2003]Smyth,M.J., Street,S.E. and Trapani,J.A.
    Cutting edge: granzymes A and B are not essential for perforin-mediated tumor rejection
    J Immunol (15-7-2003) 171, 515-518. PubMed  Europe PubMed
  51. [YEAR:15-5-2003]Tsuzuki,S., Kokado,Y., Satomi,S., Yamasaki,Y., Hirayasu,H., Iwanaga,T. and Fushiki,T.
    Purification and identification of a binding protein for pancreatic secretory trypsin inhibitor: a novel role of the inhibitor as an anti-granzyme A
    Biochem J (15-5-2003) 372, 227-233. PubMed  Europe PubMed DOI  PMC  EPMC
  52. Yamada,M., Hirasawa,A., Shiojima,S. and Tsujimoto,G.
    Granzyme A mediates glucocorticoid-induced apoptosis in leukemia cells
    FASEB J (2003) 17, 1712-1714. PubMed  Europe PubMed DOI
    53. 2001
  53. [YEAR:16-11-2001]Beresford,P.J., Zhang,D., Oh,D.Y., Fan,Z., Greer,E.L., Russo,M.L., Jaju,M. and Lieberman,J.
    Granzyme A activates an endoplasmic reticulum-associated caspase-independent nuclease to induce single-stranded DNA nicks
    J Biol Chem (16-11-2001) 276, 43285-43293. PubMed  Europe PubMed DOI
  54. Davis,J.E., Smyth,M.J. and Trapani,J.A.
    Granzyme A and B-deficient killer lymphocytes are defective in eliciting DNA fragmentation but retain potent in vivo anti-tumor capacity
    Eur J Immunol (2001) 31, 39-47. PubMed  Europe PubMed DOI
  55. [YEAR:8-5-2001]Zhang,D., Beresford,P.J., Greenberg,A.H. and Lieberman,J.
    Granzymes A and B directly cleave lamins and disrupt the nuclear lamina during granule-mediated cytolysis
    Proc Natl Acad Sci U S A (8-5-2001) 98, 5746-5751. PubMed  Europe PubMed DOI  PMC  EPMC
    56. 2000
  56. Pereira,R.A., Simon,M.M. and Simmons,A.
    Granzyme A, a noncytolytic component of CD8(+) cell granules, restricts the spread of herpes simplex virus in the peripheral nervous systems of experimentally infected mice
    J Virol (2000) 74, 1029-1032. PubMed  Europe PubMed DOI  PMC  EPMC
  57. [YEAR:15-2-2000]Spaeny-Dekking,E.H., Kamp,A.M., Froelich,C.J. and Hack,C.E.
    Extracellular granzyme A, complexed to proteoglycans, is protected against inactivation by protease inhibitors
    Blood (15-2-2000) 95, 1465-1472. PubMed  Europe PubMed
    58. 1999
  58. Blink,E.J., Trapani,J.A. and Jans,D.A.
    Perforin-dependent nuclear targeting of granzymes: A central role in the nuclear events of granule-exocytosis-mediated apoptosis?
    Immunol Cell Biol (1999) 77, 206-215. PubMed  Europe PubMed DOI
  59. [YEAR:23-11-1999]Mullbacher,A., Waring,P., Tha Hla,R., Tran,T., Chin,S., Stehle,T., Museteanu,C. and Simon,M.M.
    Granzymes are the essential downstream effector molecules for the control of primary virus infections by cytolytic leukocytes
    Proc Natl Acad Sci U S A (23-11-1999) 96, 13950-13955. PubMed  Europe PubMed DOI  PMC  EPMC
    60. 1998
  60. Jans,D.A., Briggs,L.J., Jans,P., Froelich,C.J., Parasivam,G., Kumar,S., Sutton,V.R. and Trapani,J.A.
    Nuclear targeting of the serine protease granzyme A (fragmentin-1)
    J Cell Sci (1998) 111, 2645-2654. PubMed  Europe PubMed
  61. [YEAR:15-6-1998]Mabee,C.L., McGuire,M.J. and Thiele,D.L.
    Dipeptidyl peptidase I and granzyme A are coordinately expressed during CD8+ T cell development and differentiation
    J Immunol (15-6-1998) 160, 5880-5885. PubMed  Europe PubMed
  62. [YEAR:1-12-1998]Presnell,S.R., Patil,G.S., Mura,C., Jude,K.M., Conley,J.M., Bertrand,J.A., Kam,C.M., Powers,J.C. and Williams,L.D.
    Oxyanion-mediated inhibition of serine proteases
    Biochemistry (1-12-1998) 37, 17068-17081. PubMed  Europe PubMed DOI  S  I
  63. [YEAR:1-4-1998]Spaeny-Dekking,E.H., Hanna,W.L., Wolbink,A.M., Wever,P.C., Kummer,A.J., Swaak,A.J., Middeldorp,J.M., Huisman,H.G., Froelich,C.J. and Hack,C.E.
    Extracellular granzymes A and B in humans: detection of native species during CTL responses in vitro and in vivo
    J Immunol (1-4-1998) 160, 3610-3616. PubMed  Europe PubMed
    64. 1997
  64. Beresford,P.J., Kam,C.M., Powers,J.C. and Lieberman,J.
    Recombinant human granzyme A binds to two putative HLA-associated proteins and cleaves one of them
    Proc Natl Acad Sci U S A (1997) 94, 9285-9290. PubMed  Europe PubMed DOI  PMC  EPMC
  65. Kato,Y., Yokochi,T., Sasaki,K., Kawamoto,Y., Tsuji,T. and Miyama,A.
    The major component of Na-CBZ-L-lysine thiobenzyl ester (BLT)-specific proteases in cytoplasmic granules of murine intraepithelial lymphocytes is granzyme A
    Immunobiology (1997) 196, 465-474.  I
    66. 1996
  66. Koo,G.C., Luk,Y., Talento,A., Wu,J., Sirotina,A., Fischer,P.A., Blake,J.T., Nguyen,M.P., Parsons,W. and Poe,M.
    Association of serine protease with the rise of intracellular calcium in cytotoxic T lymphocytes
    Cell Immunol (1996) 174, 107-115. PubMed  Europe PubMed DOI
  67. Kummer,J.A., Kamp,A.M., Citarella,F., Horrevoets,A.J. and Hack,C.E.
    Expression of human recombinant granzyme A zymogen and its activation by the cysteine proteinase cathepsin C
    J Biol Chem (1996) 271, 9281-9286. PubMed  Europe PubMed DOI
  68. Mullbacher,A., Ebnet,K., Blanden,R.V., Hla,R.T., Stehle,T., Museteanu,C. and Simon,M.M.
    Granzyme A is critical for recovery of mice from infection with the natural cytopathic viral pathogen, ectromelia
    Proc Natl Acad Sci U S A (1996) 93, 5783-5787. PubMed  Europe PubMed DOI  PMC  EPMC
  69. Smyth,M.J., O'Connor,M.D. and Trapani,J.A.
    Granzymes: a variety of serine protease specificities encoded by genetically distinct subfamilies
    J Leukoc Biol (1996) 60, 555-562. PubMed  Europe PubMed  V
    70. 1995
  70. Ebnet,K., Hausmann,M., Lehmann-Grube,F., Mullbacher,A., Kopf,M., Lamers,M. and Simon,M.M.
    Granzyme A-deficient mice retain potent cell-mediated cytotoxicity
    EMBO J (1995) 14, 4230-4239. PubMed  Europe PubMed  PMC  EPMC  K
  71. Irmler,M., Hertig,S., MacDonald,H.R., Sadoul,R., Becherer,J.D., Proudfoot,A., Solari,R. and Tschopp,J.
    Granzyme A is an interleukin 1beta-converting enzyme
    J Exp Med (1995) 181, 1917-1922. PubMed  Europe PubMed  PMC  EPMC
    72. 1994
  72. Simon,M.M. and Kramer,M.D.
    Granzyme A
    Methods Enzymol (1994) 244, 68-79. PubMed  Europe PubMed DOI  V
    73. 1993
  73. Fink,T.M., Lichter,P., Wekerle,H., Zimmer,M. and Jenne,D.E.
    The human granzyme A (HFSP, CTLA3) gene maps to 5q11-q12 and defines a new locus of the serine protease superfamily
    Genomics (1993) 18, 401-403. PubMed  Europe PubMed DOI
  74. Hanna,W.L., Zhang,X., Turbov,J., Winkler,U., Hudig,D. and Froelich,C.J.
    Rapid purification of cationic granule proteases: application to human granzymes
    Protein Expr Purif (1993) 4, 398-404. PubMed  Europe PubMed DOI
  75. [YEAR:6-7-1993]Kummer,J.A., Kamp,A.M., van Katwijk,M., Brakenhoff,J.P., Radosevic,K., van Leeuwen,A.M., Borst,J., Verweij,C.L. and Hack,C.E.
    Production and characterization of monoclonal antibodies raised against recombinant human granzymes A and B and showing cross reactions with the natural proteins
    J Immunol Methods (6-7-1993) 163, 77-83. PubMed  Europe PubMed DOI
  76. Nakamura,K., Arahata,K., Ishiura,S., Osame,M. and Sugita,H.
    Degradative activity of granzyme A on skeletal muscle proteins in vitro: a possible molecular mechanism for muscle fiber damage in polymyositis
    Neuromuscul Disord (1993) 3, 303-310. PubMed  Europe PubMed DOI
    77. 1992
  77. Hershberger,R.J., Gershenfeld,H.K., Weissman,I.L. and Su,L.
    Genomic organization of the mouse granzyme A gene. Two mRNAs encode the same mature granzyme A with different leader peptides
    J Biol Chem (1992) 267, 25488-25493. PubMed  Europe PubMed  R
  78. Talento,A., Nguyen,M., Law,S., Wu,J.K., Poe,M., Blake,J.T., Patel,M., Wu,T.J., Manyak,C.L., Silberklang,M., Mark,G., Springer,M., Sigal,N.H., Weissman,I.L., Bleackley,R.C., Podack,E.R., Tykocinski,M.L. and Koo,G.C.
    Transfection of mouse cytotoxic T lymphocyte with an antisense granzyme A vector reduces lytic activity
    J Immunol (1992) 149, 4009-4015. PubMed  Europe PubMed  K
    79. 1991
  79. Odake,S., Kam,C.M., Narasimhan,L., Poe,M., Blake,J.T., Krahenbuhl,O., Tschopp,J. and Powers,J.C.
    Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins
    Biochemistry (1991) 30, 2217-2227. PubMed  Europe PubMed  I
  80. Simon,M.M., Kramer,M.D., Prester,M. and Gay,S.
    Mouse T-cell associated serine proteinase 1 degrades collagen type IV: A structural basis for the migration of lymphocytes through vascular basement membranes
    Immunology (1991) 73, 117-119. PubMed  Europe PubMed  PMC  EPMC
    81. 1990
  81. Simon,M.M., Tran,T., Fruth,U., Gurwitz,D. and Kramer,M.D.
    Regulation of mouse T cell associated serine proteinase-1 (MTSP- 1) by proteinase inhibitors and sulfated polysaccharides
    Biol Chem Hoppe Seyler (1990) 371 Suppl, 81-87. PubMed  Europe PubMed
    82. 1988
  82. Gershenfeld,H.K., Hershberger,R.J., Shows,T.B. and Weissman,I.L.
    Cloning and chromosomal assignment of a human cDNA encoding a T cell- and natural killer cell-specific trypsin-like serine protease
    Proc Natl Acad Sci U S A (1988) 85, 1184-1188. PubMed  Europe PubMed  PMC  EPMC
  83. [YEAR:15-9-1988]Poe,M., Bennett,C.D., Biddison,W.E., Blake,J.T., Norton,G.P., Rodkey,J.A., Sigal,N.H., Turner,R.V., Wu,J.K. and Zweerink,H.J.
    Human cytotoxic lymphocyte tryptase. Its purification from granules and the characterization of inhibitor and substrate specificity
    J Biol Chem (15-9-1988) 263, 13215-13222. PubMed  Europe PubMed
  84. Simon,H.G., Fruth,U., Eckerskorn,C., Lottspeich,F., Kramer,M.D., Nerz,G. and Simon,M.M.
    Induction of T cell serine proteinase 1 (TSP-1)-specific mRNA in mouse T lymphocytes
    Eur J Immunol (1988) 18, 855-861. PubMed  Europe PubMed DOI
  85. Simon,M.M., Prester,M., Nerz,G., Kramer,M.D. and Fruth,U.
    Release of biologically active fragments from human plasma-fibronectin by murine T cell-specific proteinase 1 (TSP-1)
    Biol Chem Hoppe Seyler (1988) 369 Suppl, 107-112. PubMed  Europe PubMed
    86. 1987
  86. Fruth,U., Sinigaglia,F., Schlesier,M., Kilgus,J., Kramer,M.D. and Simon,M.M.
    A novel serine proteinase (HuTSP) isolated from a cloned human CD8+ cytolytic T cell line is expressed and secreted by activated CD4+ and CD8+ lymphocytes
    Eur J Immunol (1987) 17, 1625-1633. PubMed  Europe PubMed DOI
    87. 1986
  87. Masson,D., Zamai,M. and Tschopp,J.
    Identification of granzyme A isolated from cytotoxic T-lymphocyte-granules as one of the proteases encoded by CTL-specific genes
    FEBS Lett (1986) 208, 84-88. PubMed  Europe PubMed
  88. Simon,M.M., Hoschutzky,H., Fruth,U., Simon,H.G. and Kramer,M.D.
    Purification and characterization of a T cell specific serine proteinase (TSP-1) from cloned cytolytic T lymphocytes
    EMBO J (1986) 5, 3267-3274. PubMed  Europe PubMed  PMC  EPMC

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2026 EBI
Terms of use