$VAR1 = undef;

Summary for peptidase S01.133: cathepsin G

Names
MEROPS Name	cathepsin G
Other names	CatG, CTSG g.p. (Homo sapiens), Stat5 protease

Domain architecture

MEROPS Classification
Classification	Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.133
Holotype	cathepsin G (Homo sapiens), Uniprot accession P08311 (peptidase unit: 21-245), MERNUM MER0000082
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Serine
Peplist	Included in the Peplist with identifier PL00271
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.20
Enzymology	BRENDA database
Proteolytic events	CutDB database (31 cleavages)
Activity status	human: active (Salvesen, 2004) mouse: active (MacIvor et al., 1999)
Physiology	Cathepsin G is bactericidal, and contributes to the digestion of bacteria by polymorphonuclear leukocytes. It has been suggested that neutrophils auto-regulate their lytic efficiency by controlling the exocytosis of primary granules via cathepsin G activity (Ottonello et al., 2004). Cathepsin G has also been known as "STAT5 protease" because of its activity in processing signal transducer and activator of transcription (STAT) proteins (Schuster %et al, 2007).
Knockout	Cathepsin G-deficient mice had no distinctive phenotype (MacIvor et al., 1999), but the enzyme seemed to contribute to the intracellular killing of fungi in neutrophil leukocytes, and to sensitivity to endotoxic shock (Tkalcevic et al., 2000).
Pathways	KEGG	Amoebiasis
	KEGG	Lysosome
	KEGG	Neuroactive ligand-receptor interaction
	KEGG	Renin-angiotensin system
	KEGG	Systemic lupus erythematosus
Other databases	WIKIPEDIA	http://en.wikipedia.org/wiki/Cathepsin_G
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/v/-/lhfs/-/-/v (based on 465 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	34	34	13	2	36	33	52	40
Pro	35	6	45	0	2	4	35	19
Ala	18	34	36	6	50	24	120	43
Val	26	120	30	15	38	31	22	128
Leu	13	27	106	108	29	34	13	21
Ile	21	20	32	14	21	13	16	21
Met	17	3	10	31	9	6	6	4
Phe	12	12	6	94	11	18	23	10
Tyr	9	5	4	47	4	11	8	5
Trp	1	4	2	1	5	91	6	1
Ser	12	23	27	0	138	31	17	24
Thr	7	17	45	4	17	24	23	11
Cys	5	7	1	0	3	1	2	8
Asn	8	14	15	16	23	23	13	18
Gln	21	22	24	3	18	9	15	9
Asp	95	22	12	5	6	46	29	17
Glu	24	48	37	2	5	37	21	46
Lys	0	2	5	3	19	1	12	20
Arg	12	6	3	3	8	3	9	2
His	20	8	5	105	14	15	9	4