$VAR1 = undef;

Summary for peptidase M35.004: peptidyl-Lys metallopeptidase

Names
MEROPS Name	peptidyl-Lys metallopeptidase
Other names	Am-LysN, GfMep (Grifola), metalloendopeptidase Lys-N, PoMep (Pleurotus sp.)

Domain architecture

MEROPS Classification
Classification	Clan MA >> Subclan MA(D) >> Family M35 >> Subfamily (none) >> M35.004
Holotype	peptidyl-Lys metallopeptidase (Armillaria mellea), Uniprot accession Q9Y7F7 (peptidase unit: 184-351), MERNUM MER0005595
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Metallo
Peplist	Included in the Peplist with identifier PL00252
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase 3.4.24.20
Enzymology	BRENDA database
Proteolytic events	CutDB database (1 cleavage)
Physiology	Role in nutrition of organism.
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/-/-/-K/-/-/- (based on 2105 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	123	135	140	175	0	116	166	141
Pro	117	107	84	86	0	87	72	101
Ala	154	154	149	159	0	159	158	149
Val	117	131	118	108	0	125	126	167
Leu	179	192	229	223	0	163	238	188
Ile	120	116	121	101	0	105	147	143
Met	60	73	82	73	0	85	55	54
Phe	54	46	78	60	0	60	92	74
Tyr	56	50	56	52	0	69	53	80
Trp	19	20	28	26	0	13	16	20
Ser	149	147	162	159	0	150	145	149
Thr	114	124	123	92	0	126	124	117
Cys	34	18	34	39	0	30	27	30
Asn	78	91	82	101	0	89	87	74
Gln	85	85	85	105	0	92	97	96
Asp	139	137	93	114	0	132	112	107
Glu	214	209	162	204	0	214	145	173
Lys	131	111	127	108	2105	112	126	105
Arg	102	112	112	94	0	128	82	99
His	56	44	39	26	0	48	35	36