$VAR1 = undef;
Summary for peptidase M26.001: IgA1-specific metallopeptidase
| Names | |
|---|---|
| MEROPS Name | IgA1-specific metallopeptidase |
| Other names | immunoglobulin A1 proteinase, IgA protease (Streptococcus sp.) |
| Domain architecture |
|---|
| MEROPS Classification | |
|---|---|
| Classification | Clan MA >> Subclan MA(E) >> Family M26 >> Subfamily (none) >> M26.001 |
| Holotype | IgA1-specific metallopeptidase (Streptococcus sanguinis), Uniprot accession Q59986 (peptidase unit: 530-1878), MERNUM MER0001173 |
| History | Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London. |
| Activity | |||
|---|---|---|---|
| Catalytic type | Metallo | ||
| Peplist | Included in the Peplist with identifier PL00242 | ||
| NC-IUBMB | Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase 3.4.24.13 | ||
| Enzymology | BRENDA database | ||
| Activity | The enzyme from {Streptococcus pneumoniae} has been expressed in active form (<%Romanello %etal, 2005[20050921A060]%>). | ||
| Proteolytic events | CutDB database (1 cleavage) | ||
| Specificity | Specific for cleavage of the hinge region of IgA1. | ||
| Physiology | Inactivation of host IgA1 in immune avoidance possible. | ||
