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Literature for peptidase M26.001: IgA1-specific metallopeptidase

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates

(Topics flags: A Assay, I Inhibitor, E Expression, V Review, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Tran,N., Redzic,J.S., Eisenmesser,E.Z. and Holyoak,T.
    The structure of the Gemella haemolysans M26 IgA1 protease trypsin-like domain
    Acta Crystallogr F Struct Biol Commun PubMed  Europe PubMed DOI
    2. 2022
  2. Kilian,M., Husby,S., Andersen,J., Moldoveanu,Z., Sorensen,U.B.S., Reinholdt,J. and Tettelin,H.
    Induction of Susceptibility to Disseminated Infection with IgA1 Protease-Producing Encapsulated Pathogens Streptococcus pneumoniae, Haemophilus influenzae Type b, and Neisseria meningitidis
    MBio13, e0055022-e0055022. PubMed  Europe PubMed DOI
    3. 2020
  3. Wang,Z., Rahkola,J., Redzic,J.S., Chi,Y.C., Tran,N., Holyoak,T., Zheng,H., Janoff,E. and Eisenmesser,E.
    Mechanism and inhibition of Streptococcus pneumoniae IgA1 protease
    Nat Commun11, 6063-6063. PubMed  Europe PubMed DOI
    4. 2017
  4. Chi,Y.C., Rahkola,J.T., Kendrick,A.A., Holliday,M.J., Paukovich,N., Roberts,T.S., Janoff,E.N. and Eisenmesser,E.Z.
    Streptococcus pneumoniae IgA1 protease: a metalloprotease that can catalyze in a split manner in vitro
    Protein Sci26, 600-610. PubMed  Europe PubMed DOI
    5. 2016
  5. Fu,L., Zhao,J., Lin,L., Zhang,Q., Xu,Z., Han,L., Xie,C., Zhou,R., Jin,M. and Zhang,A.
    Characterization of IgA1 protease as a surface protective antigen of Streptococcus suis serotype 2
    Microbes Infect18, 285-289. PubMed  Europe PubMed DOI
    6. 2014
  6. Janoff,E.N., Rubins,J.B., Fasching,C., Charboneau,D., Rahkola,J.T., Plaut,A.G. and Weiser,J.N.
    Pneumococcal IgA1 protease subverts specific protection by human IgA1
    Mucosal Immunol7, 249-256. PubMed  Europe PubMed DOI
    7. 2013
  7. Choudary,S.K., Qiu,J., Plaut,A.G. and Kritzer,J.A.
    Versatile substrates and probes for IgA1 protease activity
    Chembiochem14, 2007-2012. PubMed  Europe PubMed DOI  A
  8. Garner,A.L., Fullagar,J.L., Day,J.A., Cohen,S.M. and Janda,K.D.
    Development of a high-throughput screen and its use in the discovery of Streptococcus pneumoniae immunoglobulin A1 protease inhibitors
    J Am Chem Soc135, 10014-10017. PubMed  Europe PubMed DOI  A  I
    9. 2012
  9. Bek-Thomsen,M., Poulsen,K. and Kilian,M.
    Occurrence and evolution of the paralogous zinc metalloproteases IgA1 protease, ZmpB, ZmpC, and ZmpD in Streptococcus pneumoniae and related commensal species
    MBio3, e00303-e00312. PubMed  Europe PubMed DOI
  10. Plaut,A.G. and Qiu,J.
    IgA-specific metalloendopeptidase
    [ISSN:978-0-12-407744-7]3, 1243-1248. DOI
    11. 2010
  11. Xie,L.S., Huang,J., Qin,W. and Fan,J.M.
    Immunoglobulin A1 protease: a new therapeutic candidate for immunoglobulin A nephropathy
    Nephrology (Carlton)15, 584-586. PubMed  Europe PubMed DOI  U
    12. 2007
  12. De Paolis,F., Beghetto,E., Spadoni,A., Montagnani,F., Felici,F., Oggioni,M.R. and Gargano,N.
    Identification of a human immunodominant B-cell epitope within the immunoglobulin A1 protease of Streptococcus pneumoniae
    BMC Microbiol7, 113-113. PubMed  Europe PubMed DOI
    13. 2006
  13. [YEAR:15-6-2006]Bender,M.H. and Weiser,J.N.
    The atypical amino-terminal LPNTG-containing domain of the pneumococcal human IgA1-specific protease is required for proper enzyme localization and function
    Mol Microbiol61, 526-543. PubMed  Europe PubMed DOI
  14. Camilli,R., Pettini,E., Del Grosso,M., Pozzi,G., Pantosti,A. and Oggioni,M.R.
    Zinc metalloproteinase genes in clinical isolates of Streptococcus pneumoniae: association of the full array with a clonal cluster comprising serotypes 8 and 11A
    Microbiology (Reading)152, 313-321. PubMed  Europe PubMed DOI
  15. [YEAR:5-9-2006]Romanello,V., Marcacci,M., Dal Molin,F., Moschioni,M., Censini,S., Covacci,A., Baritussio,A.G., Montecucco,C. and Tonello,F.
    Cloning, expression, purification, and characterization of Streptococcus pneumoniae IgA1 protease
    Protein Expr Purif45, 142-149. PubMed  Europe PubMed DOI  E
  16. [YEAR:15-9-2006]Senior,B.W. and Woof,J.M.
    Sites in the CH3 domain of human IgA1 that influence sensitivity to bacterial IgA1 proteases
    J Immunol177, 3913-3919. PubMed  Europe PubMed
  17. Takenouchi-Ohkubo,N., Mortensen,L.M., Drasbek,K.R., Kilian,M. and Poulsen,K.
    Horizontal transfer of the immunoglobulin A1 protease gene (iga) from Streptococcus to Gemella haemolysans
    Microbiology (Reading)152, 2171-2180. PubMed  Europe PubMed DOI
  18. [YEAR:21-9-2006]Walker,S.G., Carnu,O.I., Tuter,G. and Ryan,M.E.
    The immunoglobulin A1 proteinase from Streptococcus pneumoniae is inhibited by tetracycline compounds
    FEMS Immunol Med Microbiol48, 218-222. PubMed  Europe PubMed DOI  I
    19. 2005
  19. [YEAR:15-6-2005]Senior,B.W. and Woof,J.M.
    The influences of hinge length and composition on the susceptibility of human IgA to cleavage by diverse bacterial IgA1 proteases
    J Immunol174, 7792-7799. PubMed  Europe PubMed
  20. Senior,B.W. and Woof,J.M.
    Effect of mutations in the human immunoglobulin A1 (IgA1) hinge on its susceptibility to cleavage by diverse bacterial IgA1 proteases
    Infect Immun73, 1515-1522. PubMed  Europe PubMed DOI
    21. 2004
  21. Plaut,A.G.
    IgA1-specific metalloendopeptidase
    [ISSN:0-12-079610-4]2, 772-776.  V
    22. 2003
  22. Batten,M.R., Senior,B.W., Kilian,M. and Woof,J.M.
    Amino acid sequence requirements in the hinge of human immunoglobulin A1 (IgA1) for cleavage by streptococcal IgA1 proteases
    Infect Immun71, 1462-1469. PubMed  Europe PubMed DOI
  23. [YEAR:3-7-2003]Chiavolini,D., Memmi,G., Maggi,T., Iannelli,F., Pozzi,G. and Oggioni,M.R.
    The three extra-cellular zinc metalloproteinases of Streptococcus pneumoniae have a different impact on virulence in mice
    BMC Microbiol3, 14-14. PubMed  Europe PubMed DOI
  24. Oggioni,M.R., Memmi,G., Maggi,T., Chiavolini,D., Iannelli,F. and Pozzi,G.
    Pneumococcal zinc metalloproteinase ZmpC cleaves human matrix metalloproteinase 9 and is a virulence factor in experimental pneumonia
    Mol Microbiol49, 795-805. PubMed  Europe PubMed DOI
  25. [YEAR:1-4-2003]Weiser,J.N., Bae,D., Fasching,C., Scamurra,R.W., Ratner,A.J. and Janoff,E.N.
    Antibody-enhanced pneumococcal adherence requires IgA1 protease
    Proc Natl Acad Sci U S A100, 4215-4220. PubMed  Europe PubMed DOI
    26. 2002
  26. Senior,B.W., Batten,M.R., Kilian,M. and Woof,J.M.
    Amino acid sequence requirements in the human IgA1 hinge for cleavage by streptococcal IgA1 proteases
    Biochem Soc Trans30, 516-518. PubMed  Europe PubMed DOI
    27. 2000
  27. Lomholt,J.A. and Kilian,M.
    Immunoglobulin A1 protease activity in Gemella haemolysans
    J Clin Microbiol38, 2760-2762. PubMed  Europe PubMed
  28. Senior,B.W., Dunlop,J.I., Batten,M.R., Kilian,M. and Woof,J.M.
    Cleavage of a recombinant human immunoglobulin A2 (IgA2)-IgA1 hybrid antibody by certain bacterial IgA1 proteases
    Infect Immun68, 463-469. PubMed  Europe PubMed DOI
    29. 1998
  29. Poulsen,K., Reinholdt,J., Jespersgaard,C., Boye,K., Brown,T.A., Hauge,M. and Kilian,M.
    A comprehensive genetic study of streptococcal immunoglobulin A1 proteases: evidence for recombination within and between species
    Infect Immun66, 181-190. PubMed  Europe PubMed
  30. Tyler,B.M. and Cole,M.F.
    Effect of IgA1 protease on the ability of secretory IgA1 antibodies to inhibit the adherence of Streptococcus mutans
    Microbiol Immunol42, 503-508. PubMed  Europe PubMed
    31. 1997
  31. Reinholdt,J. and Kilian,M.
    Comparative analysis of immunoglobulin A1 protease activity among bacteria representing different genera, species, and strains
    Infect Immun65, 4452-4459. PubMed  Europe PubMed
  32. Yokota,K. and Oguma,K.
    IgA protease produced by Streptococcus sanguis and antibody production against IgA protease in patients with Behcet's disease
    Microbiol Immunol41, 925-931. PubMed  Europe PubMed
    33. 1996
  33. Kilian,M., Reinholdt,J., Lomholt,H., Poulsen,K. and Frandsen,E.V.
    Biological significance of IgA1 proteases in bacterial colonization and pathogenesis: critical evaluation of experimental evidence
    APMIS104, 321-338. PubMed  Europe PubMed  V
  34. Poulsen,K., Reinholdt,J. and Kilian,M.
    Characterization of the Streptococcus pneumoniae immunoglobulin A1 protease gene (iga) and its translation product
    Infect Immun64, 3957-3966. PubMed  Europe PubMed
  35. Wani,J.H., Gilbert,J.V., Plaut,A.G. and Weiser,J.N.
    Identification, cloning, and sequencing of the immunoglobulin A1 protease gene of Streptococcus pneumoniae
    Infect Immun64, 3967-3974. PubMed  Europe PubMed
    36. 1995
  36. Plaut,A.G. and Wright,A.
    Immunoglobulin A-metallo-type specific prolyl endopeptidases
    Methods Enzymol248, 634-642. PubMed  Europe PubMed DOI  V
    37. 1994
  37. Mulks,M.H. and Shoberg,R.J.
    Bacterial immunoglobulin A1 proteases
    Methods Enzymol235, 543-554. PubMed  Europe PubMed DOI  V
  38. Plaut,A.G. and Bachovchin,W.W.
    IgA-specific prolyl endopeptidases: serine type
    Methods Enzymol244, 137-151. PubMed  Europe PubMed DOI  V
    39. 1991
  39. Gilbert,J.V., Plaut,A.G. and Wright,A.
    Analysis of the immunoglobulin A protease gene of Streptococcus sanguis
    Infect Immun59, 7-17. PubMed  Europe PubMed
    40. 1988
  40. Gilbert,J.V., Plaut,A.G., Fishman,Y. and Wright,A.
    Cloning of the gene encoding streptococcal immunoglobulin A protease and its expression in Escherichia coli
    Infect Immun56, 1961-1966. PubMed  Europe PubMed
    41. 1981
  41. Kornfeld,S.J. and Plaut,A.G.
    Secretory immunity and the bacterial IgA proteases
    Rev Infect Dis3, 521-534. PubMed  Europe PubMed
    42. 1978
  42. Plaut,A.G., Gilbert,J.V. and Heller,I.
    Assay and properties of IgA protease of Streptococcus sanguis
    Adv Exp Med Biol107, 489-495. PubMed  Europe PubMed
    43. 1977
  43. Plaut,A.G., Gilbert,J.V. and Wistar,R., Jr.
    Loss of antibody activity in human immunoglobulin A exposed to extracellualr immunoglobulin A proteases of Neisseria gonorhoeae and Streptococcus sanguis
    Infect Immun17, 130-135. PubMed  Europe PubMed
    44. 1974
  44. Plaut,A.G., Genco,R.J. and Tomasi,T.B., Jr.
    Isolation of an enzyme from Streptococcus sanguis which specifically cleaves IgA
    J Immunol113, 589-591. PubMed  Europe PubMed

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