$VAR1 = undef;

Summary for peptidase M23.002: staphylolysin

Names
MEROPS Name	staphylolysin
Other names	LasA protein (Pseudomonas aeruginosa), pseudoalterin (Pseudoalteromonas sp.), staphylolytic endopeptidase

Domain architecture

MEROPS Classification
Classification	Clan MO >> Subclan (none) >> Family M23 >> Subfamily A >> M23.002
Holotype	staphylolysin (Pseudomonas aeruginosa), Uniprot accession P14789 (peptidase unit: 190-369), MERNUM MER0001282
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Metallo
Peplist	Included in the Peplist with identifier PL00234
NC-IUBMB	Not yet included in IUBMB recommendations.
Proteolytic events	CutDB database (1 cleavage)
Physiology	Causes lysis of Staphylococcus aureus cells.
Pharmaceutical relevance	Staphylolysin has been found to be effective in the treatment of experimental S. aureus keratitis in rabbits, and suggested to have potential for the treatment of disease in humans (Barequet et al., 2004).
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/-/G/GGaf/-/-/- (based on 12 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	0	0	9	12	5	0	0	0
Pro	0	0	0	0	0	0	0	0
Ala	0	0	0	0	4	2	0	1
Val	0	0	0	0	0	0	0	1
Leu	0	3	0	0	0	0	0	0
Ile	0	0	0	0	0	0	0	0
Met	0	0	0	0	0	0	0	0
Phe	0	0	0	0	2	1	0	0
Tyr	0	0	0	0	0	0	0	0
Trp	0	0	0	0	0	0	0	0
Ser	0	0	0	0	0	0	0	0
Thr	0	0	0	0	0	0	0	0
Cys	0	0	0	0	0	0	0	0
Asn	0	0	0	0	0	0	0	0
Gln	0	0	0	0	0	0	2	0
Asp	0	0	0	0	0	0	0	0
Glu	0	0	0	0	0	0	0	0
Lys	0	0	0	0	0	1	0	0
Arg	0	0	0	0	0	0	0	0
His	2	0	0	0	0	0	0	0