$VAR1 = undef;

Summary for peptidase M16.003: mitochondrial processing peptidase beta-subunit

Names
MEROPS Name	mitochondrial processing peptidase beta-subunit
Other names	MPP, PMPCB g.p. (Homo sapiens), processing enhancing protein

Domain architecture

MEROPS Classification
Classification	Clan ME >> Subclan (none) >> Family M16 >> Subfamily B >> M16.003
Holotype	mitochondrial processing peptidase beta-subunit (Saccharomyces cerevisiae), Uniprot accession P10507 (peptidase unit: 30-245), MERNUM MER0001229
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Metallo
Peplist	Included in the Peplist with identifier PL00222
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase 3.4.24.64
Enzymology	BRENDA database
Physiology	Processes N-terminal targetting peptides from mitochondrial proteins during import.
Other databases	TREEFAM	http://www.treefam.org/family/TF105032
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/r/R/-ylfa/sa/-/- (based on 86 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	4	1	1	6	3	5	2	9
Pro	6	1	1	2	1	1	5	5
Ala	17	11	6	9	10	11	9	13
Val	7	13	1	2	2	2	4	4
Leu	15	7	5	9	20	0	4	5
Ile	1	2	0	0	2	1	1	2
Met	2	1	0	4	1	0	0	0
Phe	2	1	0	11	16	0	0	0
Tyr	0	1	0	8	25	1	1	2
Trp	0	0	0	1	0	1	1	1
Ser	6	11	2	12	4	40	16	12
Thr	3	5	1	7	0	6	18	6
Cys	2	1	0	3	1	1	2	0
Asn	2	0	3	5	0	0	5	5
Gln	8	2	0	0	1	0	6	3
Asp	0	0	0	0	0	2	4	4
Glu	1	0	1	0	0	4	2	3
Lys	2	6	0	1	0	1	2	6
Arg	5	22	65	3	0	6	1	1
His	3	1	0	3	0	4	3	3