$VAR1 = undef;

Summary for peptidase M16.001: pitrilysin

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

 

Names
MEROPS Namepitrilysin
Other namesEscherichia coli protease III, Escherichia coli protease Pi
Domain architecture
MEROPS Classification
Classification Clan ME >> Subclan (none) >> Family M16 >> Subfamily A >> M16.001
Holotypepitrilysin (Escherichia coli), Uniprot accession P05458 (peptidase unit: 24-232), MERNUM MER0001222
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeMetallo
PeplistIncluded in the Peplist with identifier PL00220
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase 3.4.24.55
EnzymologyBRENDA database
Other databases PANTHERhttp://www.pantherdb.org/panther/familyList.do?searchType=basic&fieldName=all&listType=6&fieldValue=PTHR43690:SF11
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/-/-Scissile bond-/-/-/- (based on 23 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 1 2 2 2 0 1 0 1
Pro 1 0 0 0 0 0 1 1
Ala 1 1 0 0 0 1 2 1
Val 2 3 1 0 0 1 0 1
Leu 0 2 5 4 3 2 1 1
Ile 0 0 0 0 2 0 2 2
Met 0 1 0 0 1 2 1 1
Phe 1 4 4 3 1 1 2 1
Tyr 2 1 1 3 1 0 0 1
Trp 0 0 0 1 0 1 0 0
Ser 1 0 3 1 1 3 3 2
Thr 2 2 1 1 2 1 0 2
Cys 1 0 0 0 1 0 0 0
Asn 2 0 2 0 2 3 1 0
Gln 2 0 0 0 1 2 2 2
Asp 0 0 1 0 0 0 2 0
Glu 2 0 0 0 0 0 1 1
Lys 2 4 1 3 4 2 1 2
Arg 1 1 1 3 4 2 1 0
His 0 0 1 2 0 0 0 1