$VAR1 = undef;

Summary for peptidase M13.003: endothelin-converting enzyme 2

Names
MEROPS Name	endothelin-converting enzyme 2
Other names	ECE-2

Domain architecture

MEROPS Classification
Classification	Clan MA >> Subclan MA(E) >> Family M13 >> Subfamily (none) >> M13.003
Holotype	endothelin-converting enzyme 2 (Bos taurus), Uniprot accession Q10711 (peptidase unit: 111-787), MERNUM MER0001991
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Metallo
NC-IUBMB	Not yet included in IUBMB recommendations.
Proteolytic events	CutDB database (13 cleavages)
Activity status	human: active (Ahn, 2004) mouse: putative
Knockout	Endothelin-converting enzyme 2 null mice develop normally, are healthy into adulthood, are fertile in both sexes, and live a normal life span. However, when they are bred into an Endothelin-converting enzyme 1-null background, defects in cardiac outflow structures become more severe than those in ECE-1 single knockout embryos (Yanagisawa et al., 2000).
Other databases	TREEFAM	http://www.treefam.org/family/TF315192
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/r/-/-f/-/t/rvdp (based on 17 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	4	0	2	2	0	0	0	0
Pro	1	0	3	3	0	0	0	2
Ala	1	1	0	1	0	0	0	0
Val	1	0	0	0	3	2	1	3
Leu	1	2	2	1	2	3	2	0
Ile	0	3	2	0	2	1	0	0
Met	0	0	2	0	0	1	2	0
Phe	0	2	2	0	4	0	0	0
Tyr	1	1	0	1	3	0	0	0
Trp	2	2	0	2	2	2	0	0
Ser	0	0	1	0	0	0	0	0
Thr	0	0	0	0	0	0	3	0
Cys	0	0	0	0	0	0	0	0
Asn	0	0	0	0	0	2	0	0
Gln	1	1	0	1	0	2	0	0
Asp	2	0	0	2	0	0	0	2
Glu	0	0	0	2	0	0	0	0
Lys	0	0	0	1	0	2	2	0
Arg	3	5	2	1	1	1	2	3
His	0	0	1	0	0	1	0	0