$VAR1 = undef;
Summary for peptidase M12.133: fibrolase
| Names | |
|---|---|
| MEROPS Name | fibrolase |
| Other names | Alfimeprase, copperhead venom fibrinolytic proteinase |
| Domain architecture |
|---|
| MEROPS Classification | |
|---|---|
| Classification | Clan MA >> Subclan MA(M) >> Family M12 >> Subfamily B >> M12.133 |
| Holotype | fibrolase (Agkistrodon contortrix contortrix), Uniprot accession P28891 (peptidase unit: 1-203), MERNUM MER0001130 |
| History | Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London. |
| Activity | |||
|---|---|---|---|
| Catalytic type | Metallo | ||
| Peplist | Included in the Peplist with identifier PL00180 | ||
| NC-IUBMB | Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase 3.4.24.72 | ||
| Enzymology | BRENDA database | ||
| Proteolytic events | CutDB database (1 cleavage) | ||
| Physiology | Likely role in snake venom toxicity, preventing blood coagulation by destruction of fibrin and fibrinogen. | ||
| Pharmaceutical relevance | Potential target for vaccine development. | ||
