$VAR1 = undef;

Summary for peptidase M12.004: meprin beta subunit

Names
MEROPS Name	meprin beta subunit
Other names	kinase-splitting membrane proteinase (KSMP), MEP1B g.p. (Homo sapiens), meprin-b, meprin A beta component, meprin B, PABA peptide hydrolase, N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase beta component

Domain architecture

MEROPS Classification
Classification	Clan MA >> Subclan MA(M) >> Family M12 >> Subfamily A >> M12.004
Holotype	meprin beta subunit (Mus musculus), Uniprot accession Q61847 (peptidase unit: 65-254), MERNUM MER0005214
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Metallo
Peplist	Included in the Peplist with identifier PL00175
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase 3.4.24.18;
Enzymology	BRENDA database
Proteolytic events	CutDB database (22 cleavages)
Activity status	human: active (Bertenshaw & Bond, 2004) mouse: active (Bond et al., 1984)
Structure	This is the sole peptidase unit of meprin B, and also one of the two peptidase units of meprin A, which contains both alpha and beta units in separate polypeptide chains.
Knockout	Disruption of the meprin beta allele in mice affects embryonic viability, birth weight, renal gene expression profiles, and the distribution of meprin alpha in kidney and intestine (Norman et al., 2003).
Pathways	KEGG	Protein digestion and absorption
Other databases	TREEFAM	http://www.treefam.org/family/TF315280
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/-/-/-de/-/-/- (based on 935 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	81	61	29	78	37	75	75	89
Pro	37	69	57	4	4	117	88	42
Ala	76	86	87	112	79	103	88	76
Val	35	68	93	6	22	60	82	78
Leu	72	84	104	45	29	36	91	69
Ile	32	49	42	4	14	25	69	58
Met	19	13	28	36	7	16	17	13
Phe	34	38	41	46	10	33	23	32
Tyr	16	16	31	33	9	24	18	15
Trp	4	8	11	12	2	13	7	8
Ser	63	51	53	89	56	52	64	60
Thr	38	46	49	13	36	46	63	49
Cys	9	4	5	11	2	8	8	6
Asn	34	30	29	59	22	26	34	33
Gln	44	40	72	60	10	47	33	32
Asp	66	37	56	82	352	59	34	63
Glu	86	61	91	141	226	142	71	112
Lys	91	82	19	25	5	25	42	61
Arg	61	57	8	41	2	4	5	11
His	21	23	23	37	9	22	20	25