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Literature for peptidase M12.004: meprin beta subunit

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, A Assay, P Specificity, K Knockout, E Expression, V Review, M Mutation, I Inhibitor. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Abousaad,S., Ahmed,F., Abouzeid,A., Adhiambo,C. and Ongeri,E.
    Meprin beta activity modulates cellular proliferation via trans-signaling IL-6-mediated AKT/ERK pathway in IR-induced kidney injury
    Res Sq PubMed  Europe PubMed DOI
  2. Ahmed,F., Abousaad,S., Abouzeid,A., Adhiambo,C. and Ongeri,E.M.
    Meprin beta regulates osteopontin-signaling in ischemia/reperfusion-induced kidney injury
    BMC Nephrol26, 90-90. PubMed  Europe PubMed DOI
    3. 2024
  3. Armbrust,F., Bickenbach,K., Altmeppen,H., Foggetti,A., Winkelmann,A., Wulff,P., Glatzel,M., Pietrzik,C.U. and Becker-Pauly,C.
    A novel mouse model for N-terminal truncated Abeta2-x generation through meprin beta overexpression in astrocytes
    Cell Mol Life Sci81, 139-139. PubMed  Europe PubMed DOI
  4. Jana,S., Banerjee,S., Baidya,S.K., Ghosh,B., Jha,T. and Adhikari,N.
    A combined ligand-based and structure-based in silico molecular modeling approach to pinpoint the key structural attributes of hydroxamate derivatives as promising meprin beta inhibitors
    J Biomol Struct Dyn1-17. PubMed  Europe PubMed DOI
    5. 2023
  5. Bulck,C., Nystrom,E.E.L., Koudelka,T., Mannbar-Frahm,M., Andresen,G., Radhouani,M., Tran,F., Scharfenberg,F., Schrell,F., Armbrust,F., Dahlke,E., Zhao,B., Vervaeke,A., Theilig,F., Rosenstiel,P., Starkl,P., Rosshart,S.P., Fickenscher,H., Tholey,A., Hansson,G.C. and Becker-Pauly,C.
    Proteolytic processing of galectin-3 by meprin metalloproteases is crucial for host-microbiome homeostasis
    Sci Adv9, eadf4055-eadf4055. PubMed  Europe PubMed DOI
    6. 2021
  6. Eckhard,U., Korschgen,H., von Wiegen,N., Stocker,W. and Gomis-Ruth,F.X.
    The crystal structure of a 250-kDa heterotetrameric particle explains inhibition of sheddase meprin beta by endogenous fetuin-B
    Proc Natl Acad Sci U S A118, PubMed  Europe PubMed DOI
  7. Gellrich,A., Scharfenberg,F., Peters,F., Sammel,M., Helm,O., Armbrust,F., Schmidt,F., Lokau,J., Garbers,C., Sebens,S., Arnold,P. and Becker-Pauly,C.
    Characterization of the Cancer-Associated Meprin Betaeta Variants G45R and G89R
    Front Mol Biosci8, 702341-702341. PubMed  Europe PubMed DOI
  8. Li,W., Luckstadt,W., Wohner,B., Bub,S., Schulz,A., Socher,E. and Arnold,P.
    Structural and functional properties of meprin beta metalloproteinase with regard to cell signaling
    Biochim Biophys Acta Mol Cell Res1869, 119136-119136. PubMed  Europe PubMed DOI
  9. Linnert,M., Fritz,C., Jager,C., Schlenzig,D., Ramsbeck,D., Kleinschmidt,M., Wermann,M., Demuth,H.U., Parthier,C. and Schilling,S.
    Structure and Dynamics of Meprin beta in Complex with a Hydroxamate-Based Inhibitor
    Int J Mol Sci22, PubMed  Europe PubMed DOI
  10. Luckstadt,W., Bub,S., Koudelka,T., Pavlenko,E., Peters,F., Somasundaram,P., Becker-Pauly,C., Lucius,R., Zunke,F. and Arnold,P.
    Cell Surface Processing of CD109 by Meprin beta Leads to the Release of Soluble Fragments and Reduced Expression on Extracellular Vesicles
    Front Cell Dev Biol9, 622390-622390. PubMed  Europe PubMed DOI
  11. Tan,K., Jager,C., Korschgen,H., Geissler,S., Schlenzig,D., Buchholz,M., Stocker,W. and Ramsbeck,D.
    Heteroaromatic Inhibitors of the Astacin Proteinases Meprin alpha, Meprin beta and Ovastacin Discovered by a Scaffold-Hopping Approach
    ChemMedChem16, 976-988. PubMed  Europe PubMed DOI
  12. Werny,L., Colmorgen,C. and Becker-Pauly,C.
    Regulation of meprin metalloproteases in mucosal homeostasis
    Biochim Biophys Acta Mol Cell Res1869, 119158-119158. PubMed  Europe PubMed DOI  V
    13. 2020
  13. Ahmed,F., Mwiza,J.M., Fernander,M., Yahaya,I., Abousaad,S. and Ongeri,E.M.
    Meprin-beta activity modulates the beta-catalytic subunit of protein kinase A in ischemia-reperfusion-induced acute kidney injury
    Am J Physiol Renal Physiol318, F1147-F1147. PubMed  Europe PubMed DOI
  14. Berner,D.K., Wessolowski,L., Armbrust,F., Schneppenheim,J., Schlepckow,K., Koudelka,T., Scharfenberg,F., Lucius,R., Tholey,A., Kleinberger,G., Haass,C., Arnold,P. and Becker-Pauly,C.
    Meprin beta cleaves TREM2 and controls its phagocytic activity on macrophages
    FASEB J34, 6675-6687. PubMed  Europe PubMed DOI
  15. Dholey,Y., Chaudhuri,A. and Sen Chakraborty,S.
    An integrated in silico approach to understand protein-protein interactions: human meprin-beta with fetuin-A
    J Biomol Struct Dyn38, 2080-2092. PubMed  Europe PubMed DOI
  16. Gindorf,M., Storck,S.E., Ohler,A., Scharfenberg,F., Becker-Pauly,C. and Pietrzik,C.U.
    Meprin beta: a novel regulator of blood-brain barrier integrity
    J Cereb Blood Flow Metab271678X20905206-271678X2271678X. PubMed  Europe PubMed DOI
    17. 2019
  17. Chaudhuri,A., Hudait,N. and Chakraborty,S.S.
    Pharmacophore modeling coupled with molecular dynamic simulation approach to identify new leads for meprin-beta metalloprotease
    Comput Biol Chem80, 292-306. PubMed  Europe PubMed DOI  I
  18. Gooding,J., Cao,L., Ahmed,F., Mwiza,J.M., Fernander,M., Whitaker,C., Acuff,Z., McRitchie,S., Sumner,S. and Ongeri,E.M.
    LC-MS-based metabolomics analysis to identify meprin beta-associated changes in kidney tissue from mice with STZ-induced type 1 diabetes and diabetic kidney injury
    Am J Physiol Renal Physiol317, F1034-F1034. PubMed  Europe PubMed DOI
  19. Herzog,C., Haun,R.S. and Kaushal,G.P.
    Role of meprin metalloproteinases in cytokine processing and inflammation
    Cytokine114, 18-25. PubMed  Europe PubMed DOI
  20. Karmilin,K., Schmitz,C., Kuske,M., Korschgen,H., Olf,M., Meyer,K., Hildebrand,A., Felten,M., Fridrich,S., Yiallouros,I., Becker-Pauly,C., Weiskirchen,R., Jahnen-Dechent,W., Floehr,J. and Stocker,W.
    Mammalian plasma fetuin-B is a selective inhibitor of ovastacin and meprin metalloproteinases
    Sci Rep9, 546-546. PubMed  Europe PubMed DOI
  21. Menon,P.K., Koistinen,N.A., Iverfeldt,K. and Strom,A.L.
    Phosphorylation of the amyloid precursor protein (APP) at Ser-675 promotes APP processing involving meprin beta
    J Biol Chem294, 17768-17776. PubMed  Europe PubMed DOI
  22. Peters,F. and Becker-Pauly,C.
    Role of meprin metalloproteases in metastasis and tumor microenvironment
    Cancer Metastasis Rev38, 347-356. PubMed  Europe PubMed DOI
  23. Schaffler,H., Li,W., Helm,O., Kruger,S., Boger,C., Peters,F., Rocken,C., Sebens,S., Lucius,R., Becker-Pauly,C. and Arnold,P.
    The cancer associated meprin beta variant p.G32R provides an additional activation site and promotes cancer cell invasion
    J Cell Sci132, jcs220665-jcs220665. PubMed  Europe PubMed DOI  M
  24. Scharfenberg,F., Armbrust,F., Marengo,L., Pietrzik,C. and Becker-Pauly,C.
    Regulation of the alternative beta-secretase meprin beta by ADAM-mediated shedding
    Cell Mol Life Sci76, 3193-3206. PubMed  Europe PubMed DOI
  25. Wichert,R., Scharfenberg,F., Colmorgen,C., Koudelka,T., Schwarz,J., Wetzel,S., Potempa,B., Potempa,J., Bartsch,J.W., Sagi,I., Tholey,A., Saftig,P., Rose-John,S. and Becker-Pauly,C.
    Meprin beta induces activities of a disintegrin and metalloproteinases 9, 10, and 17 by specific prodomain cleavage
    FASEB J33, 11925-11940. PubMed  Europe PubMed DOI
    26. 2018
  26. Adhikari,N., Amin,S.A., Ghosh,B. and Jha,T.
    Shedding light on designing potential meprin beta inhibitors through ligand-based robust validated computational approaches: a proposal to chemists!
    J Biomol Struct Dyn36, 3003-3022. PubMed  Europe PubMed DOI  I
  27. Ramsbeck,D., Hamann,A., Richter,G., Schlenzig,D., Geissler,S., Nykiel,V., Cynis,H., Schilling,S. and Buchholz,M.
    Structure-guided design, synthesis, and characterization of next-generation meprin beta inhibitors
    J Med Chem61, 4578-4592. PubMed  Europe PubMed DOI  I
  28. Schlenzig,D., Cynis,H., Hartlage-Rubsamen,M., Zeitschel,U., Menge,K., Fothe,A., Ramsbeck,D., Spahn,C., Wermann,M., Rossner,S., Buchholz,M., Schilling,S. and Demuth,H.U.
    Dipeptidyl-peptidase activity of meprin beta links N-truncation of Abeta with glutaminyl cyclase-catalyzed pGlu-Abeta formation
    J Alzheimers Dis66, 359-375. PubMed  Europe PubMed DOI
  29. Schulze,A., Wermann,M., Demuth,H.U., Yoshimoto,T., Ramsbeck,D., Schlenzig,D. and Schilling,S.
    Continuous assays for meprin alpha and beta using prolyl tripeptidyl aminopeptidase (PtP) from Porphyromonas gingivalis
    Anal Biochem559, 11-16. PubMed  Europe PubMed DOI  A  I
    30. 2017
  30. Arnold,P., Otte,A. and Becker-Pauly,C.
    Meprin metalloproteases: molecular regulation and function in inflammation and fibrosis
    Biochim Biophys Acta1864, 2096-2104. PubMed  Europe PubMed DOI
  31. Arnold,P., Boll,I., Rothaug,M., Schumacher,N., Schmidt,F., Wichert,R., Schneppenheim,J., Lokau,J., Pickhinke,U., Koudelka,T., Tholey,A., Rabe,B., Scheller,J., Lucius,R., Garbers,C., Rose-John,S. and Becker-Pauly,C.
    Meprin metalloproteases generate biologically active soluble interleukin-6 receptor to induce trans-signaling
    Sci Rep7, 44053-44053. PubMed  Europe PubMed DOI
  32. Arnold,P., Koopmann,L., Peters,F., Birkenfeld,F., Goff,S.V., Damm,T., Qin,C., Moali,C., Lucius,R. and Becker-Pauly,C.
    Deficiency of the DSPP-cleaving enzymes meprin alpha and meprin beta does not result in dentin malformation in mice
    Cell Tissue Res367, 351-358. PubMed  Europe PubMed DOI  K
  33. Bedau,T., Schumacher,N., Peters,F., Prox,J., Arnold,P., Koudelka,T., Helm,O., Schmidt,F., Rabe,B., Jentzsch,M., Rosenstiel,P., Sebens,S., Tholey,A., Rose-John,S. and Becker-Pauly,C.
    Cancer-associated mutations in the canonical cleavage site do not influence CD99 shedding by the metalloprotease meprin beta but alter cell migration in vitro
    Oncotarget8, 54873-54888. PubMed  Europe PubMed DOI
  34. Bedau,T., Peters,F., Prox,J., Arnold,P., Schmidt,F., Finkernagel,M., Kollmann,S., Wichert,R., Otte,A., Ohler,A., Stirnberg,M., Lucius,R., Koudelka,T., Tholey,A., Biasin,V., Pietrzik,C.U., Kwapiszewska,G. and Becker-Pauly,C.
    Ectodomain shedding of CD99 within highly conserved regions is mediated by the metalloprotease meprin beta and promotes transendothelial cell migration
    FASEB J31, 1226-1237. PubMed  Europe PubMed DOI
  35. Biasin,V., Wygrecka,M., Marsh,L.M., Becker-Pauly,C., Brcic,L., Ghanim,B., Klepetko,W., Olschewski,A. and Kwapiszewska,G.
    Meprin beta contributes to collagen deposition in lung fibrosis
    Sci Rep7, 39969-39969. PubMed  Europe PubMed DOI  K
  36. Schlenzig,D. and Schilling,S.
    Heterologous expression of the astacin protease meprin beta in Pichia pastoris
    Methods Mol Biol1579, 35-45. PubMed  Europe PubMed DOI  E
  37. Schneppenheim,J., Scharfenberg,F., Lucius,R., Becker-Pauly,C. and Arnold,P.
    Meprin beta and BMP-1 are differentially regulated by CaCl2
    Cell Calcium65, 8-13. PubMed  Europe PubMed DOI
  38. Wichert,R., Ermund,A., Schmidt,S., Schweinlin,M., Ksiazek,M., Arnold,P., Knittler,K., Wilkens,F., Potempa,B., Rabe,B., Stirnberg,M., Lucius,R., Bartsch,J.W., Nikolaus,S., Falk-Paulsen,M., Rosenstiel,P., Metzger,M., Rose-John,S., Potempa,J., Hansson,G.C., Dempsey,P.J. and Becker-Pauly,C.
    Mucus detachment by host metalloprotease meprin beta requires shedding of its inactive pro-form, which is abrogated by the pathogenic protease RgpB
    Cell Rep21, 2090-2103. PubMed  Europe PubMed DOI
    39. 2016
  39. Becker-Pauly,C. and Pietrzik,C.U.
    The metalloprotease meprin beta is an alternative beta-secretase of APP
    Front Mol Neurosci9, 159-159. PubMed  Europe PubMed DOI  P
  40. Chaudhuri,A., Bera,A.K., Sarkar,I. and Chakraborty,S.
    Insights from analysis of binding sites of human meprins: screening of inhibitors by molecular dynamics simulation study
    Comb Chem High Throughput Screen19, 246-258. PubMed  Europe PubMed  I
  41. Herzog,C., Haun,R.S., Shah,S.V. and Kaushal,G.P.
    Proteolytic processing and inactivation of CCL2/MCP-1 by meprins
    Biochem Biophys Rep8, 146-150. PubMed  Europe PubMed DOI
  42. Martin,B.L., Conley,S.M., Harris,R.S., Stanley,C.D., Niyitegeka,J.M. and Ongeri,E.M.
    Hypoxia associated proteolytic processing of OS-9 by the metalloproteinase meprin beta
    Int J Nephrol2016, 2851803-2851803. PubMed  Europe PubMed DOI  K
  43. Sato,Y., Kobayashi,D., Kohno,T., Kidani,Y., Prox,J., Becker-Pauly,C. and Hattori,M.
    Determination of cleavage site of reelin between its sixth and seventh repeat and contribution of meprin metalloproteases to the cleavage
    J Biochem159, 305-312. PubMed  Europe PubMed DOI  P
  44. Schmidt,F., Muller,M., Prox,J., Arnold,P., Schonherr,C., Tredup,C., Minder,P., Ebsen,H., Janssen,O., Annaert,W., Pietrzik,C., Schmidt-Arras,D., Sterchi,E.E. and Becker-Pauly,C.
    Tetraspanin 8 is an interactor of the metalloprotease meprin beta within tetraspanin-enriched microdomains
    Biol Chem PubMed  Europe PubMed DOI
  45. Schonherr,C., Bien,J., Isbert,S., Wichert,R., Prox,J., Altmeppen,H., Kumar,S., Walter,J., Lichtenthaler,S.F., Weggen,S., Glatzel,M., Becker-Pauly,C. and Pietrzik,C.U.
    Generation of aggregation prone N-terminally truncated amyloid beta peptides by meprin beta depends on the sequence specificity at the cleavage site
    Mol Neurodegener11, 19-19. PubMed  Europe PubMed DOI  K
    46. 2015
  46. Arnold,P., Schmidt,F., Prox,J., Zunke,F., Pietrzik,C., Lucius,R. and Becker-Pauly,C.
    Calcium negatively regulates meprin beta activity and attenuates substrate cleavage
    FASEB J29, 3549-3557. PubMed  Europe PubMed DOI
  47. Becker-Pauly,C. and Rose-John,S.
    Meprin and ADAM metalloproteases: two sides of the same coin?
    Matrix Metalloproteinase Biol115-130. DOI  P
  48. Herzog,C., Marisiddaiah,R., Haun,R.S. and Kaushal,G.P.
    Basement membrane protein nidogen-1 is a target of meprin beta in cisplatin nephrotoxicity
    Toxicol Lett236, 110-116. PubMed  Europe PubMed DOI
  49. Jackle,F., Schmidt,F., Wichert,R., Arnold,P., Prox,J., Mangold,M., Ohler,A., Pietrzik,C.U., Koudelka,T., Tholey,A., Gutschow,M., Stirnberg,M. and Becker-Pauly,C.
    Metalloprotease meprin beta is activated by transmembrane serine protease matriptase-2 at the cell surface thereby enhancing APP shedding
    Biochem J470, 91-103. PubMed  Europe PubMed DOI
  50. Jodal,A., Pape,F., Becker-Pauly,C., Maas,O., Schibli,R. and Behe,M.
    Evaluation of (1) (1) (1)In-labelled exendin-4 derivatives containing different meprin beta-specific cleavable linkers
    PLoS ONE10, e0123443-e0123443. PubMed  Europe PubMed DOI
  51. Marin,I.
    Origin and diversification of meprin proteases
    PLoS ONE10, e0135924-e0135924. PubMed  Europe PubMed DOI
  52. Niyitegeka,J.M., Bastidas,A.C., Newman,R.H., Taylor,S.S. and Ongeri,E.M.
    Isoform-specific interactions between meprin metalloproteases and the catalytic subunit of protein kinase A: significance in acute and chronic kidney injury
    Am J Physiol Renal Physiol308, F56-F68. PubMed  Europe PubMed DOI
  53. Prox,J., Arnold,P. and Becker-Pauly,C.
    Meprin alpha and meprin beta: procollagen proteinases in health and disease
    Matrix Biol44-46C, 7-13. PubMed  Europe PubMed DOI
  54. Schlenzig,D., Wermann,M., Ramsbeck,D., Moenke-Wedler,T. and Schilling,S.
    Expression, purification and initial characterization of human meprin beta from Pichia pastoris
    Protein Expr Purif116, 75-81. PubMed  Europe PubMed DOI  E
    55. 2014
  55. Becker-Pauly,C., Broder,C., Prox,J., Koudelka,T. and Tholey,A.
    Mapping orphan proteases by proteomics: meprin metalloproteases deciphered as potential therapeutic targets
    Proteomics Clin Appl8, 382-388. PubMed  Europe PubMed DOI  P
  56. Biasin,V., Marsh,L.M., Egemnazarov,B., Wilhelm,J., Ghanim,B., Klepetko,W., Wygrecka,M., Olschewski,H., Eferl,R., Olschewski,A. and Kwapiszewska,G.
    Meprin beta, a novel mediator of vascular remodelling underlying pulmonary hypertension
    J Pathol233, 7-17. PubMed  Europe PubMed DOI
  57. Chaudhuri,A., Sarkar,I. and Chakraborty,S.
    Comparative analysis of binding sites of human meprins with hydroxamic acid derivative by molecular dynamics simulation study
    J Biomol Struct Dyn32, 1969-1978. PubMed  Europe PubMed DOI  I
  58. Keiffer,T.R. and Bond,J.S.
    Meprin metalloproteases inactivate interleukin 6
    J Biol Chem289, 7580-7588. PubMed  Europe PubMed DOI
  59. Li,Y.J., Fan,Y.H., Tang,J., Li,J.B. and Yu,C.H.
    Meprin-beta regulates production of pro-inflammatory factors via a disintegrin and metalloproteinase-10 (ADAM-10) dependent pathway in macrophages
    Int Immunopharmacol18, 77-84. PubMed  Europe PubMed DOI
  60. Madoux,F., Tredup,C., Spicer,T.P., Scampavia,L., Chase,P.S., Hodder,P.S., Fields,G.B., Becker-Pauly,C. and Minond,D.
    Development of high throughput screening assays and pilot screen for inhibitors of metalloproteases meprin alpha and beta
    Biopolymers102, 396-406. PubMed  Europe PubMed DOI  A
  61. Schutte,A., Ermund,A., Becker-Pauly,C., Johansson,M.E., Rodriguez-Pineiro,A.M., Backhed,F., Muller,S., Lottaz,D., Bond,J.S. and Hansson,G.C.
    Microbial-induced meprin beta cleavage in MUC2 mucin and a functional CFTR channel are required to release anchored small intestinal mucus
    Proc Natl Acad Sci U S A111, 12396-12401. PubMed  Europe PubMed DOI
    62. 2013
  62. Broder,C. and Becker-Pauly,C.
    The metalloproteases meprin alpha and meprin beta: unique enzymes in inflammation, neurodegeneration, cancer and fibrosis
    Biochem J450, 253-264. PubMed  Europe PubMed DOI  V
  63. Broder,C., Arnold,P., Vadon-Le Goff,S., Konerding,M.A., Bahr,K., Muller,S., Overall,C.M., Bond,J.S., Koudelka,T., Tholey,A., Hulmes,D.J., Moali,C. and Becker-Pauly,C.
    Metalloproteases meprin alpha and meprin beta are C- and N-procollagen proteinases important for collagen assembly and tensile strength
    Proc Natl Acad Sci U S A110, 14219-14224. PubMed  Europe PubMed DOI
  64. Jefferson,T., auf dem Keller,U., Bellac,C., Metz,V.V., Broder,C., Hedrich,J., Ohler,A., Maier,W., Magdolen,V., Sterchi,E., Bond,J.S., Jayakumar,A., Traupe,H., Chalaris,A., Rose-John,S., Pietrzik,C.U., Postina,R., Overall,C.M. and Becker-Pauly,C.
    The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprinbeta and ADAM10
    Cell Mol Life Sci70, 309-333. PubMed  Europe PubMed DOI  P
    65. 2012
  65. Arolas,J.L., Broder,C., Jefferson,T., Guevara,T., Sterchi,E.E., Bode,W., Stocker,W., Becker-Pauly,C. and Gomis-Ruth,F.X.
    Structural basis for the sheddase function of human meprin beta metalloproteinase at the plasma membrane
    Proc Natl Acad Sci U S A109, 16131-16136. PubMed  Europe PubMed DOI  S
  66. Bertenshaw,G.P. and Bond,J.S.
    Meprin B
    [ISSN:978-0-12-407744-7]3, 910-916. DOI
  67. Bien,J., Jefferson,T., Causevic,M., Jumpertz,T., Munter,L., Multhaup,G., Weggen,S., Becker-Pauly,C. and Pietrzik,C.U.
    The metalloprotease meprin beta generates amino terminal-truncated amyloid beta peptide species
    J Biol Chem287, 33304-33313. PubMed  Europe PubMed DOI
  68. Geurts,N., Becker-Pauly,C., Martens,E., Proost,P., Van Den Steen,P.E., Stocker,W. and Opdenakker,G.
    Meprins process matrix metalloproteinase-9 (MMP-9)/gelatinase B and enhance the activation kinetics by MMP-3
    FEBS Lett586, 4264-4269. PubMed  Europe PubMed DOI
  69. Hirano,M., Ma,B.Y., Kawasaki,N., Oka,S. and Kawasaki,T.
    Role of interaction of mannan-binding protein with meprins at the initial step of complement activation in ischemia/reperfusion injury to mouse kidney
    Glycobiology22, 84-95. PubMed  Europe PubMed DOI
    70. 2011
  70. Banerjee,S., Jin,G., Bradley,S.G., Matters,G.L., Gailey,R.D., Crisman,J.M. and Bond,J.S.
    Balance of meprin A and B in mice affects the progression of experimental inflammatory bowel disease
    Am J Physiol Gastrointest Liver Physiol300, G273-G282. PubMed  Europe PubMed DOI
  71. Becker-Pauly,C., Barre,O., Schilling,O., auf dem Keller,U., Ohler,A., Broder,C., Schutte,A., Kappelhoff,R., Stocker,W. and Overall,C.M.
    Proteomic analyses reveal an acidic prime side specificity for the astacin metalloprotease family reflected by physiological substrates
    Mol Cell Proteomics10, M111.009233- PubMed  Europe PubMed DOI  P
  72. Garcia-Caballero,A., Ishmael,S.S., Dang,Y., Gillie,D., Bond,J.S., Milgram,S.L. and Stutts,M.J.
    Activation of the epithelial sodium channel by the metalloprotease meprin beta subunit
    Channels (Austin)5, 14-22. PubMed  Europe PubMed DOI
  73. Jefferson,T., Causevic,M., auf dem Keller,U., Schilling,O., Isbert,S., Geyer,R., Maier,W., Tschickardt,S., Jumpertz,T., Weggen,S., Bond,J.S., Overall,C.M., Pietrzik,C.U. and Becker-Pauly,C.
    Metalloprotease meprin beta generates nontoxic N-terminal amyloid precursor protein fragments in vivo
    J Biol Chem286, 27741-27750. PubMed  Europe PubMed DOI
  74. Ongeri,E.M., Anyanwu,O., Reeves,W.B. and Bond,J.S.
    Villin and actin in the mouse kidney brush-border membrane bind to and are degraded by meprins, an interaction that contributes to injury in ischemia-reperfusion
    Am J Physiol Renal Physiol301, F871-F882. PubMed  Europe PubMed DOI  P
  75. Tsuchiya,S., Simmer,J.P., Hu,J.C., Richardson,A.S., Yamakoshi,F. and Yamakoshi,Y.
    Astacin proteases cleave dentin sialophosphoprotein (Dspp) to generate dentin phosphoprotein (Dpp)
    J Bone Miner Res26, 220-228. PubMed  Europe PubMed DOI  P
    76. 2010
  76. Ambort,D., Brellier,F., Becker-Pauly,C., Stocker,W., Andrejevic-Blant,S., Chiquet,M. and Sterchi,E.E.
    Specific processing of tenascin-C by the metalloprotease meprinbeta neutralizes its inhibition of cell spreading
    Matrix Biol29, 31-42. PubMed  Europe PubMed DOI  P
  77. Hedrich,J., Lottaz,D., Meyer,K., Yiallouros,I., Jahnen-Dechent,W., StoÆ^cker,W. and Becker-Pauly,C.
    Fetuin-A and cystatin C are endogenous inhibitors of human meprin metalloproteases
    Biochemistry49, 8599-8607. PubMed  Europe PubMed DOI
  78. Kronenberg,D., Bruns,B.C., Moali,C., Vadon-Le Goff,S., Sterchi,E.E., Traupe,H., Bohm,M., Hulmes,D.J., Stocker,W. and Becker-Pauly,C.
    Processing of procollagen III by meprins: new players in extracellular matrix assembly?
    J Invest Dermatol130, 2727-2735. PubMed  Europe PubMed DOI  P
  79. Ohler,A., Debela,M., Wagner,S., Magdolen,V. and Becker-Pauly,C.
    Analyzing the protease web in skin: meprin metalloproteases are activated specifically by KLK4, 5 and 8 vice versa leading to processing of proKLK7 thereby triggering its activation
    Biol Chem391, 455-460. PubMed  Europe PubMed DOI
    80. 2009
  80. Sun,Q., Jin,H.J. and Bond,J.S.
    Disruption of the meprin alpha and beta genes in mice alters homeostasis of monocytes and natural killer cells
    Exp Hematol37, 346-356. PubMed  Europe PubMed DOI  K
    81. 2008
  81. Banerjee,S. and Bond,J.S.
    Prointerleukin-18 is activated by meprin beta in vitro and in vivo in intestinal inflammation
    J Biol Chem283, 31371-31377. PubMed  Europe PubMed DOI
  82. Bylander,J., Li,Q., Ramesh,G., Zhang,B., Reeves,W.B. and Bond,J.S.
    Targeted disruption of the meprin metalloproteinase beta gene protects against renal ischemia-reperfusion injury in mice
    Am J Physiol Renal Physiol294, F480-F490. PubMed  Europe PubMed DOI  K
  83. Huguenin,M., Muller,E.J., Trachsel-Rosmann,S., Oneda,B., Ambort,D., Sterchi,E.E. and Lottaz,D.
    The metalloprotease meprin beta processes E-cadherin and weakens intercellular adhesion
    PLoS ONE3, e2153-e2153. PubMed  Europe PubMed DOI
  84. Oneda,B., Lods,N., Lottaz,D., Becker-Pauly,C., Stocker,W., Pippin,J., Huguenin,M., Ambort,D., Marti,H.P. and Sterchi,E.E.
    Metalloprotease meprin beta in rat kidney: glomerular localization and differential expression in glomerulonephritis
    PLoS ONE3, e2278-e2278. PubMed  Europe PubMed DOI
  85. Sterchi,E.E., Stocker,W. and Bond,J.S.
    Meprins, membrane-bound and secreted astacin metalloproteinases
    Mol Aspects Med29, 309-328. PubMed  Europe PubMed DOI  V
  86. Yoshimura,H., Ito,M., Kuwahara,Y., Ishii,A., Tsuritani,K., Nakamura,A., Hirasawa,Y. and Nagamatsu,T.
    Downregulated expression in high IgA (HIGA) mice and the renal protective role of meprinbeta
    Life Sci82, 899-908. PubMed  Europe PubMed DOI
    87. 2007
  87. Becker-Pauly,C., Howel,M., Walker,T., Vlad,A., Aufenvenne,K., Oji,V., Lottaz,D., Sterchi,E.E., Debela,M., Magdolen,V., Traupe,H. and Stocker,W.
    The alpha and beta subunits of the metalloprotease meprin are expressed in separate layers of human epidermis, revealing different functions in keratinocyte proliferation and differentiation
    J Invest Dermatol127, 1115-1125. PubMed  Europe PubMed DOI
  88. Schutte,A., Lottaz,D., Sterchi,E.E., Stocker,W. and Becker-Pauly,C.
    Two alpha subunits and one beta subunit of meprin zinc-endopeptidases are differentially expressed in the zebrafish Danio rerio
    Biol Chem388, 523-531. PubMed  Europe PubMed DOI
    89. 2005
  89. [YEAR:13-6-2005]Bond,J.S., Matters,G.L., Banerjee,S. and Dusheck,R.E.
    Meprin metalloprotease expression and regulation in kidney, intestine, urinary tract infections and cancer
    FEBS Lett579, 3317-3322. PubMed  Europe PubMed DOI
  90. [YEAR:8-8-2005]Herzog,C., Kaushal,G.P. and Haun,R.S.
    Generation of biologically active interleukin-1beta by meprin B
    Cytokine31, 394-403. PubMed  Europe PubMed DOI
  91. [YEAR:1-9-2005]Hirano,M., Ma,B.Y., Kawasaki,N., Okimura,K., Baba,M., Nakagawa,T., Miwa,K., Kawasaki,N., Oka,S. and Kawasaki,T.
    Mannan-binding protein blocks the activation of metalloproteases meprin alpha and beta
    J Immunol175, 3177-3185. PubMed  Europe PubMed
  92. [YEAR:4-2-2005]Ishmael,F.T., Shier,V.K., Ishmael,S.S. and Bond,J.S.
    Intersubunit and domain interactions of the meprin B metalloproteinase. Disulfide bonds and protein-protein interactions in the MAM and TRAF domains
    J Biol Chem280, 13895-13901. PubMed  Europe PubMed DOI
  93. [YEAR:25-8-2005]Red Eagle,A.R., Hanson,R.L., Jiang,W., Han,X., Matters,G.L., Imperatore,G., Knowler,W.C. and Bond,J.S.
    Meprin beta metalloprotease gene polymorphisms associated with diabetic nephropathy in the Pima Indians
    Hum Genet118, 12-22. PubMed  Europe PubMed DOI  M
    94. 2004
  94. Bertenshaw,G.P. and Bond,J.S.
    Meprin B
    [ISSN:0-12-079610-4]2, 605-609.  V
  95. [YEAR:1-4-2004]Crisman,J.M., Zhang,B., Norman,L.P. and Bond,J.S.
    Deletion of the mouse meprin beta metalloprotease gene diminishes the ability of leukocytes to disseminate through extracellular matrix
    J Immunol172, 4510-4519. PubMed  Europe PubMed
  96. [YEAR:8-6-2004]Hengst,J.A. and Bond,J.S.
    Transport of meprin subunits through the secretory pathway: role of the transmembrane and cytoplasmic domains and oligomerization
    J Biol Chem279, 34856-34864. PubMed  Europe PubMed DOI
  97. [YEAR:1-3-2004]Kruse,M.N., Becker,C., Lottaz,D., Kohler,D., Yiallouros,I., Krell,H.W., Sterchi,E.E. and Stocker,W.
    Human meprin alpha and beta homo-oligomers: cleavage of basement membrane proteins and sensitivity to metalloprotease inhibitors
    Biochem J378, 383-389. PubMed  Europe PubMed DOI  I
    98. 2003
  98. Becker,C., Kruse,M.N., Slotty,K.A., Kohler,D., Harris,J.R., Rosmann,S., Sterchi,E.E. and Stocker,W.
    Differences in the activation mechanism between the alpha and beta subunits of human meprin
    Biol Chem384, 825-831. PubMed  Europe PubMed DOI
  99. [YEAR:24-1-2003]Bertenshaw,G.P., Norcum,M.T. and Bond,J.S.
    Structure of homo- and hetero-oligomeric meprin metalloproteases. Dimers, tetramers, and high molecular mass multimers
    J Biol Chem278, 2522-2532. PubMed  Europe PubMed DOI
  100. [YEAR:31-10-2003]Hahn,D., Pischitzis,A., Roesmann,S., Hansen,M.K., Leuenberger,B., Luginbuehl,U. and Sterchi,E.E.
    Phorbol 12-myristate 13-acetate-induced ectodomain shedding and phosphorylation of the human meprinbeta metalloprotease
    J Biol Chem278, 42829-42839. PubMed  Europe PubMed DOI
  101. [YEAR:1-2-2003]Leuenberger,B., Hahn,D., Pischitzis,A., Hansen,M.K. and Sterchi,E.E.
    Human meprin beta: O-linked glycans in the intervening region of the type I membrane protein protect the C-terminal region from proteolytic cleavage and diminish its secretion
    Biochem J369, 659-665. PubMed  Europe PubMed DOI
  102. Norman,L.P., Jiang,W., Han,X., Saunders,T.L. and Bond,J.S.
    Targeted disruption of the meprin beta gene in mice leads to underrepresentation of knockout mice and changes in renal gene expression profiles
    Mol Cell Biol23, 1221-1230. PubMed  Europe PubMed DOI  K
  103. Villa,J.P., Bertenshaw,G.P., Bylander,J.E. and Bond,J.S.
    Meprin proteolytic complexes at the cell surface and in extracellular spaces
    Biochem Soc Symp2003, 53-63. PubMed  Europe PubMed
  104. [YEAR:24-10-2003]Villa,J.P., Bertenshaw,G.P. and Bond,J.S.
    Critical amino acids in the active site of meprin metalloproteinases for substrate and peptide bond specificity
    J Biol Chem278, 42545-42550. PubMed  Europe PubMed DOI  P
    105. 2002
  105. Bertenshaw,G.P., Villa,J.P., Hengst,J.A. and Bond,J.S.
    Probing the active sites and mechanisms of rat metalloproteases meprin A and B
    Biol Chem383, 1175-1183. PubMed  Europe PubMed DOI
  106. [YEAR:13-9-2002]Litovchick,L., Friedmann,E. and Shaltiel,S.
    A selective interaction between OS-9 and the carboxyl-terminal tail of meprin beta
    J Biol Chem277, 34413-34423. PubMed  Europe PubMed DOI
  107. [YEAR:23-10-2002]Sunnerhagen,M., Pursglove,S. and Fladvad,M.
    The new MATH: homology suggests shared binding surfaces in meprin tetramers and TRAF trimers
    FEBS Lett530, 1-3. PubMed  Europe PubMed DOI
    108. 2001
  108. [YEAR:20-4-2001]Bertenshaw,G.P., Turk,B.E., Hubbard,S.J., Matters,G.L., Bylander,J.E., Crisman,J.M., Cantley,L.C. and Bond,J.S.
    Marked differences between metalloproteases meprin A and B in substrate and peptide bond specificity
    J Biol Chem276, 13248-13255. PubMed  Europe PubMed DOI
    109. 2000
  109. [YEAR:2-5-2000]Jiang,W.P., Kumar,J.M., Matters,G.L. and Bond,J.S.
    Structure of the mouse metalloprotease meprin beta gene (Mep1b): Alternative splicing in cancer cells
    Gene248, 77-87. PubMed  Europe PubMed DOI
  110. [YEAR:18-8-2000]Kadowaki,T., Tsukuba,T., Bertenshaw,G.P. and Bond,J.S.
    N-linked oligosaccharides on the meprin A metalloprotease are important for secretion and enzymatic activity, but not for apical targeting
    J Biol Chem275, 25577-25584. PubMed  Europe PubMed DOI
    111. 1999
  111. Matters,G.L. and Bond,J.S.
    Expression and regulation of the meprin beta gene in human cancer cells
    Mol Carcinog25, 169-178. PubMed  Europe PubMed DOI
  112. Pischitzis,A., Hahn,D., Leuenberger,B. and Sterchi,E.E.
    N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase beta (human meprin beta). A 13-amino-acid sequence is required for proteolytic processing and subsequent secretion
    Eur J Biochem261, 421-429. PubMed  Europe PubMed DOI
    113. 1998
  113. [YEAR:30-10-1998]Litovchick,L., Chestukhin,A. and Shaltiel,S.
    The carboxyl-terminal tail of kinase splitting membranal proteinase/meprin beta is involved in its intracellular trafficking
    J Biol Chem273, 29043-29051. PubMed  Europe PubMed DOI
    114. 1997
  114. Chestukhin,A., Litovchick,L., Muradov,K., Batkin,M. and Shaltiel,S.
    Unveiling the substrate specificity of meprin beta on the basis of the site in protein kinase A cleaved by the kinase splitting membranal proteinase
    J Biol Chem272, 3153-3160. PubMed  Europe PubMed DOI
  115. Eldering,J.A., Grunberg,J., Hahn,D., Croes,H.J., Fransen,J.A. and Sterchi,E.E.
    Polarised expression of human intestinal N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase (human meprin) alpha and beta subunits in Madin-Darby canine kidney cells
    Eur J Biochem247, 920-932. PubMed  Europe PubMed
  116. Hahn,D., Lottaz,D. and Sterchi,E.E.
    C-cytosolic and transmembrane domains of the N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase alpha subunit (human meprin alpha) are essential for its retention in the endoplasmic reticulum and C-terminal processing
    Eur J Biochem247, 933-941. PubMed  Europe PubMed
  117. Johnson,G.D. and Bond,J.S.
    Activation mechanism of meprins, members of the astacin metalloendopeptidase family
    J Biol Chem272, 28126-28132. PubMed  Europe PubMed DOI
    118. 1996
  118. Dietrich,J.M., Jiang,W. and Bond,J.S.
    A novel meprin beta' mRNA in mouse embryonal and human colon carcinoma cells
    J Biol Chem271, 2271-2278. PubMed  Europe PubMed DOI
    119. 1995
  119. Bond,J.S., Rojas,K., Overhauser,J., Zoghbi,H.Y. and Jiang,W.
    The structural genes, MEP1A and MEP1B, for the alpha and beta subunits of the metalloendopeptidase meprin map to human chromosomes 6p and 18q, respectively
    Genomics25, 300-303. PubMed  Europe PubMed DOI
  120. Wolz,R.L. and Bond,J.S.
    Meprins A and B
    Methods Enzymol248, 325-345. PubMed  Europe PubMed DOI  V
    121. 1994
  121. [YEAR:11-3-1994]Johnson,G.D. and Hersh,L.B.
    Expression of meprin subunit precursors. Membrane anchoring through the beta subunit and mechanism of zymogen activation
    J Biol Chem269, 7682-7688. PubMed  Europe PubMed
  122. Marchand,P., Tang,J. and Bond,J.S.
    Membrane association and oligomeric organization of the alpha and beta subunits of mouse meprin A
    J Biol Chem269, 15388-15393. PubMed  Europe PubMed
    123. 1993
  123. [YEAR:13-12-1993]Dumermuth,E., Eldering,J.A., Grunberg,J., Jiang,W. and Sterchi,E.E.
    Cloning of the PABA peptide hydrolase alpha subunit (PPH alpha) from human small intestine and its expression in COS-1 cells
    FEBS Lett335, 367-375. PubMed  Europe PubMed DOI
  124. [YEAR:5-10-1993]Gorbea,C.M., Marchand,P., Jiang,W., Copeland,N.G., Gilbert,D.J., Jenkins,N.A. and Bond,J.S.
    Cloning, expression, and chromosomal localization of the mouse meprin beta subunit
    J Biol Chem268, 21035-21043. PubMed  Europe PubMed
  125. Grunberg,J., Dumermuth,E., Eldering,J.A. and Sterchi,E.E.
    Expression of the alpha subunit of PABA peptide hydrolase (EC 3.4.24.18) in MDCK cells. Synthesis and secretion of an enzymatically inactive homodimer
    FEBS Lett335, 376-379. PubMed  Europe PubMed DOI
    126. 1991
  126. Gorbea,C.M., Flannery,A.V. and Bond,J.S.
    Homo- and heterotetrameric forms of the membrane-bound metalloendopeptidases meprin A and B
    Arch Biochem Biophys290, 549-553. PubMed  Europe PubMed DOI
  127. Kounnas,M.Z., Wolz,R.L., Gorbea,C.M. and Bond,J.S.
    Meprin-A and -B. Cell surface endopeptidases of the mouse kidney
    J Biol Chem266, 17350-17357. PubMed  Europe PubMed
    128. 1988
  128. Sterchi,E.E., Naim,H.Y. and Lentze,M.J.
    Biosynthesis of N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase: disulfide-linked dimers are formed at the site of synthesis in the rough endoplasmic reticulum
    Arch Biochem Biophys265, 119-127. PubMed  Europe PubMed
  129. Sterchi,E.E., Naim,H.Y., Lentze,M.J., Hauri,H.P. and Fransen,J.A.
    N-Benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase: a metalloendopeptidase of the human intestinal microvillus membrane which degrades biologically active peptides
    Arch Biochem Biophys265, 105-118. PubMed  Europe PubMed
    130. 1986
  130. Stolc,V.
    Genetics of meprin in the rat
    J Genet65, 13-17. DOI
    131. 1984
  131. Bond,J.S., Beynon,R.J., Reckelhoff,J.F. and David,C.S.
    Mep-1 gene controlling a kidney metalloendopeptidase is linked to the major histocompatibility complex in mice
    Proc Natl Acad Sci U S A81, 5542-5545. PubMed  Europe PubMed

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