Literature for peptidase M12.004: meprin beta subunit

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, A Assay, P Specificity, K Knockout, E Expression, V Review, M Mutation, I Inhibitor. To select only the references relevant to a single topic, click the link above. See explanation.)

2026

Keller,M., Gallagher,C., Marengo,L., Bickenbach,K., Schmitt,U., Abukhalaf,M., Tholey,A., Kreiselmaier,S., Becker-Pauly,C., Mittmann,T. and Pietrzik,C.U. Meprin beta elevates hippocampal soluble Abeta in the APP/V717I mouse model Exp Neurol (2026) 397, 115600-115600. PubMed Europe PubMed DOI

2025

Abousaad,S., Ahmed,F., Abouzeid,A., Adhiambo,C. and Ongeri,E. Meprin beta activity modulates cellular proliferation via trans-signaling IL-6-mediated AKT/ERK pathway in IR-induced kidney injury Res Sq (2025) PubMed Europe PubMed DOI PMC EPMC
Ahmed,F., Abousaad,S., Abouzeid,A., Adhiambo,C. and Ongeri,E.M. Meprin beta regulates osteopontin-signaling in ischemia/reperfusion-induced kidney injury BMC Nephrol (2025) 26, 90-90. PubMed Europe PubMed DOI PMC EPMC

2024

Armbrust,F., Bickenbach,K., Altmeppen,H., Foggetti,A., Winkelmann,A., Wulff,P., Glatzel,M., Pietrzik,C.U. and Becker-Pauly,C. A novel mouse model for N-terminal truncated Abeta2-x generation through meprin beta overexpression in astrocytes Cell Mol Life Sci (2024) 81, 139-139. PubMed Europe PubMed DOI PMC EPMC
Jana,S., Banerjee,S., Baidya,S.K., Ghosh,B., Jha,T. and Adhikari,N. A combined ligand-based and structure-based in silico molecular modeling approach to pinpoint the key structural attributes of hydroxamate derivatives as promising meprin beta inhibitors J Biomol Struct Dyn (2024) , 1-17. PubMed Europe PubMed DOI

2023

Bulck,C., Nystrom,E.E.L., Koudelka,T., Mannbar-Frahm,M., Andresen,G., Radhouani,M., Tran,F., Scharfenberg,F., Schrell,F., Armbrust,F., Dahlke,E., Zhao,B., Vervaeke,A., Theilig,F., Rosenstiel,P., Starkl,P., Rosshart,S.P., Fickenscher,H., Tholey,A., Hansson,G.C. and Becker-Pauly,C. Proteolytic processing of galectin-3 by meprin metalloproteases is crucial for host-microbiome homeostasis Sci Adv (2023) 9, eadf4055-eadf4055. PubMed Europe PubMed DOI PMC EPMC

2022

Marengo,L., Armbrust,F., Schoenherr,C., Storck,S.E., Schmitt,U., Zampar,S., Wirths,O., Altmeppen,H., Glatzel,M., Kaether,C., Weggen,S., Becker-Pauly,C. and Pietrzik,C.U. Meprin beta knockout reduces brain Abeta levels and rescues learning and memory impairments in the APP/lon mouse model for Alzheimer's disease Cell Mol Life Sci (2022) 79, 168-168. PubMed Europe PubMed DOI PMC EPMC

2021

Eckhard,U., Korschgen,H., von Wiegen,N., Stocker,W. and Gomis-Ruth,F.X. The crystal structure of a 250-kDa heterotetrameric particle explains inhibition of sheddase meprin beta by endogenous fetuin-B Proc Natl Acad Sci U S A (2021) 118 PubMed Europe PubMed DOI PMC EPMC
Gellrich,A., Scharfenberg,F., Peters,F., Sammel,M., Helm,O., Armbrust,F., Schmidt,F., Lokau,J., Garbers,C., Sebens,S., Arnold,P. and Becker-Pauly,C. Characterization of the Cancer-Associated Meprin Betaeta Variants G45R and G89R Front Mol Biosci (2021) 8, 702341-702341. PubMed Europe PubMed DOI PMC EPMC
Li,W., Luckstadt,W., Wohner,B., Bub,S., Schulz,A., Socher,E. and Arnold,P. Structural and functional properties of meprin beta metalloproteinase with regard to cell signaling Biochim Biophys Acta Mol Cell Res (2021) 1869, 119136-119136. PubMed Europe PubMed DOI
Linnert,M., Fritz,C., Jager,C., Schlenzig,D., Ramsbeck,D., Kleinschmidt,M., Wermann,M., Demuth,H.U., Parthier,C. and Schilling,S. Structure and Dynamics of Meprin beta in Complex with a Hydroxamate-Based Inhibitor Int J Mol Sci (2021) 22 PubMed Europe PubMed DOI PMC EPMC
Luckstadt,W., Bub,S., Koudelka,T., Pavlenko,E., Peters,F., Somasundaram,P., Becker-Pauly,C., Lucius,R., Zunke,F. and Arnold,P. Cell Surface Processing of CD109 by Meprin beta Leads to the Release of Soluble Fragments and Reduced Expression on Extracellular Vesicles Front Cell Dev Biol (2021) 9, 622390-622390. PubMed Europe PubMed DOI PMC EPMC
Tan,K., Jager,C., Korschgen,H., Geissler,S., Schlenzig,D., Buchholz,M., Stocker,W. and Ramsbeck,D. Heteroaromatic Inhibitors of the Astacin Proteinases Meprin alpha, Meprin beta and Ovastacin Discovered by a Scaffold-Hopping Approach ChemMedChem (2021) 16, 976-988. PubMed Europe PubMed DOI
Werny,L., Colmorgen,C. and Becker-Pauly,C. Regulation of meprin metalloproteases in mucosal homeostasis Biochim Biophys Acta Mol Cell Res (2021) 1869, 119158-119158. PubMed Europe PubMed DOI V

2020

Ahmed,F., Mwiza,J.M., Fernander,M., Yahaya,I., Abousaad,S. and Ongeri,E.M. Meprin-beta activity modulates the beta-catalytic subunit of protein kinase A in ischemia-reperfusion-induced acute kidney injury Am J Physiol Renal Physiol (2020) 318, F1147-F1147. PubMed Europe PubMed DOI
Berner,D.K., Wessolowski,L., Armbrust,F., Schneppenheim,J., Schlepckow,K., Koudelka,T., Scharfenberg,F., Lucius,R., Tholey,A., Kleinberger,G., Haass,C., Arnold,P. and Becker-Pauly,C. Meprin beta cleaves TREM2 and controls its phagocytic activity on macrophages FASEB J (2020) 34, 6675-6687. PubMed Europe PubMed DOI
Dholey,Y., Chaudhuri,A. and Sen Chakraborty,S. An integrated in silico approach to understand protein-protein interactions: human meprin-beta with fetuin-A J Biomol Struct Dyn (2020) 38, 2080-2092. PubMed Europe PubMed DOI
Gindorf,M., Storck,S.E., Ohler,A., Scharfenberg,F., Becker-Pauly,C. and Pietrzik,C.U. Meprin beta: a novel regulator of blood-brain barrier integrity J Cereb Blood Flow Metab (2020) , 271678X20905206-271678X2271678X. PubMed Europe PubMed DOI

2019

Chaudhuri,A., Hudait,N. and Chakraborty,S.S. Pharmacophore modeling coupled with molecular dynamic simulation approach to identify new leads for meprin-beta metalloprotease Comput Biol Chem (2019) 80, 292-306. PubMed Europe PubMed DOI I
Gooding,J., Cao,L., Ahmed,F., Mwiza,J.M., Fernander,M., Whitaker,C., Acuff,Z., McRitchie,S., Sumner,S. and Ongeri,E.M. LC-MS-based metabolomics analysis to identify meprin beta-associated changes in kidney tissue from mice with STZ-induced type 1 diabetes and diabetic kidney injury Am J Physiol Renal Physiol (2019) 317, F1034-F1034. PubMed Europe PubMed DOI
Herzog,C., Haun,R.S. and Kaushal,G.P. Role of meprin metalloproteinases in cytokine processing and inflammation Cytokine (2019) 114, 18-25. PubMed Europe PubMed DOI
Karmilin,K., Schmitz,C., Kuske,M., Korschgen,H., Olf,M., Meyer,K., Hildebrand,A., Felten,M., Fridrich,S., Yiallouros,I., Becker-Pauly,C., Weiskirchen,R., Jahnen-Dechent,W., Floehr,J. and Stocker,W. Mammalian plasma fetuin-B is a selective inhibitor of ovastacin and meprin metalloproteinases Sci Rep (2019) 9, 546-546. PubMed Europe PubMed DOI PMC EPMC
Menon,P.K., Koistinen,N.A., Iverfeldt,K. and Strom,A.L. Phosphorylation of the amyloid precursor protein (APP) at Ser-675 promotes APP processing involving meprin beta J Biol Chem (2019) 294, 17768-17776. PubMed Europe PubMed DOI
Peters,F. and Becker-Pauly,C. Role of meprin metalloproteases in metastasis and tumor microenvironment Cancer Metastasis Rev (2019) 38, 347-356. PubMed Europe PubMed DOI
Schaffler,H., Li,W., Helm,O., Kruger,S., Boger,C., Peters,F., Rocken,C., Sebens,S., Lucius,R., Becker-Pauly,C. and Arnold,P. The cancer associated meprin beta variant p.G32R provides an additional activation site and promotes cancer cell invasion J Cell Sci (2019) 132, jcs220665-jcs220665. PubMed Europe PubMed DOI M
Scharfenberg,F., Armbrust,F., Marengo,L., Pietrzik,C. and Becker-Pauly,C. Regulation of the alternative beta-secretase meprin beta by ADAM-mediated shedding Cell Mol Life Sci (2019) 76, 3193-3206. PubMed Europe PubMed DOI
Wichert,R., Scharfenberg,F., Colmorgen,C., Koudelka,T., Schwarz,J., Wetzel,S., Potempa,B., Potempa,J., Bartsch,J.W., Sagi,I., Tholey,A., Saftig,P., Rose-John,S. and Becker-Pauly,C. Meprin beta induces activities of a disintegrin and metalloproteinases 9, 10, and 17 by specific prodomain cleavage FASEB J (2019) 33, 11925-11940. PubMed Europe PubMed DOI

2018

Adhikari,N., Amin,S.A., Ghosh,B. and Jha,T. Shedding light on designing potential meprin beta inhibitors through ligand-based robust validated computational approaches: a proposal to chemists! J Biomol Struct Dyn (2018) 36, 3003-3022. PubMed Europe PubMed DOI I
Ramsbeck,D., Hamann,A., Richter,G., Schlenzig,D., Geissler,S., Nykiel,V., Cynis,H., Schilling,S. and Buchholz,M. Structure-guided design, synthesis, and characterization of next-generation meprin beta inhibitors J Med Chem (2018) 61, 4578-4592. PubMed Europe PubMed DOI I
Schlenzig,D., Cynis,H., Hartlage-Rubsamen,M., Zeitschel,U., Menge,K., Fothe,A., Ramsbeck,D., Spahn,C., Wermann,M., Rossner,S., Buchholz,M., Schilling,S. and Demuth,H.U. Dipeptidyl-peptidase activity of meprin beta links N-truncation of Abeta with glutaminyl cyclase-catalyzed pGlu-Abeta formation J Alzheimers Dis (2018) 66, 359-375. PubMed Europe PubMed DOI
Schulze,A., Wermann,M., Demuth,H.U., Yoshimoto,T., Ramsbeck,D., Schlenzig,D. and Schilling,S. Continuous assays for meprin alpha and beta using prolyl tripeptidyl aminopeptidase (PtP) from Porphyromonas gingivalis Anal Biochem (2018) 559, 11-16. PubMed Europe PubMed DOI A I

2017

Arnold,P., Koopmann,L., Peters,F., Birkenfeld,F., Goff,S.V., Damm,T., Qin,C., Moali,C., Lucius,R. and Becker-Pauly,C. Deficiency of the DSPP-cleaving enzymes meprin alpha and meprin beta does not result in dentin malformation in mice Cell Tissue Res (2017) 367, 351-358. PubMed Europe PubMed DOI K
Arnold,P., Boll,I., Rothaug,M., Schumacher,N., Schmidt,F., Wichert,R., Schneppenheim,J., Lokau,J., Pickhinke,U., Koudelka,T., Tholey,A., Rabe,B., Scheller,J., Lucius,R., Garbers,C., Rose-John,S. and Becker-Pauly,C. Meprin metalloproteases generate biologically active soluble interleukin-6 receptor to induce trans-signaling Sci Rep (2017) 7, 44053-44053. PubMed Europe PubMed DOI PMC EPMC
Arnold,P., Otte,A. and Becker-Pauly,C. Meprin metalloproteases: molecular regulation and function in inflammation and fibrosis Biochim Biophys Acta (2017) 1864, 2096-2104. PubMed Europe PubMed DOI
Bedau,T., Peters,F., Prox,J., Arnold,P., Schmidt,F., Finkernagel,M., Kollmann,S., Wichert,R., Otte,A., Ohler,A., Stirnberg,M., Lucius,R., Koudelka,T., Tholey,A., Biasin,V., Pietrzik,C.U., Kwapiszewska,G. and Becker-Pauly,C. Ectodomain shedding of CD99 within highly conserved regions is mediated by the metalloprotease meprin beta and promotes transendothelial cell migration FASEB J (2017) 31, 1226-1237. PubMed Europe PubMed DOI
Bedau,T., Schumacher,N., Peters,F., Prox,J., Arnold,P., Koudelka,T., Helm,O., Schmidt,F., Rabe,B., Jentzsch,M., Rosenstiel,P., Sebens,S., Tholey,A., Rose-John,S. and Becker-Pauly,C. Cancer-associated mutations in the canonical cleavage site do not influence CD99 shedding by the metalloprotease meprin beta but alter cell migration in vitro Oncotarget (2017) 8, 54873-54888. PubMed Europe PubMed DOI
Biasin,V., Wygrecka,M., Marsh,L.M., Becker-Pauly,C., Brcic,L., Ghanim,B., Klepetko,W., Olschewski,A. and Kwapiszewska,G. Meprin beta contributes to collagen deposition in lung fibrosis Sci Rep (2017) 7, 39969-39969. PubMed Europe PubMed DOI PMC EPMC K
Schlenzig,D. and Schilling,S. Heterologous expression of the astacin protease meprin beta in Pichia pastoris Methods Mol Biol (2017) 1579, 35-45. PubMed Europe PubMed DOI E
Schneppenheim,J., Scharfenberg,F., Lucius,R., Becker-Pauly,C. and Arnold,P. Meprin beta and BMP-1 are differentially regulated by CaCl2 Cell Calcium (2017) 65, 8-13. PubMed Europe PubMed DOI
Wichert,R., Ermund,A., Schmidt,S., Schweinlin,M., Ksiazek,M., Arnold,P., Knittler,K., Wilkens,F., Potempa,B., Rabe,B., Stirnberg,M., Lucius,R., Bartsch,J.W., Nikolaus,S., Falk-Paulsen,M., Rosenstiel,P., Metzger,M., Rose-John,S., Potempa,J., Hansson,G.C., Dempsey,P.J. and Becker-Pauly,C. Mucus detachment by host metalloprotease meprin beta requires shedding of its inactive pro-form, which is abrogated by the pathogenic protease RgpB Cell Rep (2017) 21, 2090-2103. PubMed Europe PubMed DOI

2016

Becker-Pauly,C. and Pietrzik,C.U. The metalloprotease meprin beta is an alternative beta-secretase of APP Front Mol Neurosci (2016) 9, 159-159. PubMed Europe PubMed DOI PMC EPMC P
Chaudhuri,A., Bera,A.K., Sarkar,I. and Chakraborty,S. Insights from analysis of binding sites of human meprins: screening of inhibitors by molecular dynamics simulation study Comb Chem High Throughput Screen (2016) 19, 246-258. PubMed Europe PubMed I
Herzog,C., Haun,R.S., Shah,S.V. and Kaushal,G.P. Proteolytic processing and inactivation of CCL2/MCP-1 by meprins Biochem Biophys Rep (2016) 8, 146-150. PubMed Europe PubMed DOI
Martin,B.L., Conley,S.M., Harris,R.S., Stanley,C.D., Niyitegeka,J.M. and Ongeri,E.M. Hypoxia associated proteolytic processing of OS-9 by the metalloproteinase meprin beta Int J Nephrol (2016) 2016, 2851803-2851803. PubMed Europe PubMed DOI PMC EPMC K
Sato,Y., Kobayashi,D., Kohno,T., Kidani,Y., Prox,J., Becker-Pauly,C. and Hattori,M. Determination of cleavage site of reelin between its sixth and seventh repeat and contribution of meprin metalloproteases to the cleavage J Biochem (2016) 159, 305-312. PubMed Europe PubMed DOI P
Schmidt,F., Muller,M., Prox,J., Arnold,P., Schonherr,C., Tredup,C., Minder,P., Ebsen,H., Janssen,O., Annaert,W., Pietrzik,C., Schmidt-Arras,D., Sterchi,E.E. and Becker-Pauly,C. Tetraspanin 8 is an interactor of the metalloprotease meprin beta within tetraspanin-enriched microdomains Biol Chem (2016) PubMed Europe PubMed DOI
Schonherr,C., Bien,J., Isbert,S., Wichert,R., Prox,J., Altmeppen,H., Kumar,S., Walter,J., Lichtenthaler,S.F., Weggen,S., Glatzel,M., Becker-Pauly,C. and Pietrzik,C.U. Generation of aggregation prone N-terminally truncated amyloid beta peptides by meprin beta depends on the sequence specificity at the cleavage site Mol Neurodegener (2016) 11, 19-19. PubMed Europe PubMed DOI PMC EPMC K

2015

Arnold,P., Schmidt,F., Prox,J., Zunke,F., Pietrzik,C., Lucius,R. and Becker-Pauly,C. Calcium negatively regulates meprin beta activity and attenuates substrate cleavage FASEB J (2015) 29, 3549-3557. PubMed Europe PubMed DOI
Becker-Pauly,C. and Rose-John,S. Meprin and ADAM metalloproteases: two sides of the same coin? Matrix Metalloproteinase Biol (2015) , 115-130. DOI P
Herzog,C., Marisiddaiah,R., Haun,R.S. and Kaushal,G.P. Basement membrane protein nidogen-1 is a target of meprin beta in cisplatin nephrotoxicity Toxicol Lett (2015) 236, 110-116. PubMed Europe PubMed DOI
Jackle,F., Schmidt,F., Wichert,R., Arnold,P., Prox,J., Mangold,M., Ohler,A., Pietrzik,C.U., Koudelka,T., Tholey,A., Gutschow,M., Stirnberg,M. and Becker-Pauly,C. Metalloprotease meprin beta is activated by transmembrane serine protease matriptase-2 at the cell surface thereby enhancing APP shedding Biochem J (2015) 470, 91-103. PubMed Europe PubMed DOI
Jodal,A., Pape,F., Becker-Pauly,C., Maas,O., Schibli,R. and Behe,M. Evaluation of (1) (1) (1)In-labelled exendin-4 derivatives containing different meprin beta-specific cleavable linkers PLoS ONE (2015) 10, e0123443-e0123443. PubMed Europe PubMed DOI
Marin,I. Origin and diversification of meprin proteases PLoS ONE (2015) 10, e0135924-e0135924. PubMed Europe PubMed DOI
Niyitegeka,J.M., Bastidas,A.C., Newman,R.H., Taylor,S.S. and Ongeri,E.M. Isoform-specific interactions between meprin metalloproteases and the catalytic subunit of protein kinase A: significance in acute and chronic kidney injury Am J Physiol Renal Physiol (2015) 308, F56-F68. PubMed Europe PubMed DOI
Prox,J., Arnold,P. and Becker-Pauly,C. Meprin alpha and meprin beta: procollagen proteinases in health and disease Matrix Biol (2015) 44-46C, 7-13. PubMed Europe PubMed DOI
Schlenzig,D., Wermann,M., Ramsbeck,D., Moenke-Wedler,T. and Schilling,S. Expression, purification and initial characterization of human meprin beta from Pichia pastoris Protein Expr Purif (2015) 116, 75-81. PubMed Europe PubMed DOI E

2014

Becker-Pauly,C., Broder,C., Prox,J., Koudelka,T. and Tholey,A. Mapping orphan proteases by proteomics: meprin metalloproteases deciphered as potential therapeutic targets Proteomics Clin Appl (2014) 8, 382-388. PubMed Europe PubMed DOI P
Biasin,V., Marsh,L.M., Egemnazarov,B., Wilhelm,J., Ghanim,B., Klepetko,W., Wygrecka,M., Olschewski,H., Eferl,R., Olschewski,A. and Kwapiszewska,G. Meprin beta, a novel mediator of vascular remodelling underlying pulmonary hypertension J Pathol (2014) 233, 7-17. PubMed Europe PubMed DOI
Chaudhuri,A., Sarkar,I. and Chakraborty,S. Comparative analysis of binding sites of human meprins with hydroxamic acid derivative by molecular dynamics simulation study J Biomol Struct Dyn (2014) 32, 1969-1978. PubMed Europe PubMed DOI I
Keiffer,T.R. and Bond,J.S. Meprin metalloproteases inactivate interleukin 6 J Biol Chem (2014) 289, 7580-7588. PubMed Europe PubMed DOI
Li,Y.J., Fan,Y.H., Tang,J., Li,J.B. and Yu,C.H. Meprin-beta regulates production of pro-inflammatory factors via a disintegrin and metalloproteinase-10 (ADAM-10) dependent pathway in macrophages Int Immunopharmacol (2014) 18, 77-84. PubMed Europe PubMed DOI
Madoux,F., Tredup,C., Spicer,T.P., Scampavia,L., Chase,P.S., Hodder,P.S., Fields,G.B., Becker-Pauly,C. and Minond,D. Development of high throughput screening assays and pilot screen for inhibitors of metalloproteases meprin alpha and beta Biopolymers (2014) 102, 396-406. PubMed Europe PubMed DOI A
Schutte,A., Ermund,A., Becker-Pauly,C., Johansson,M.E., Rodriguez-Pineiro,A.M., Backhed,F., Muller,S., Lottaz,D., Bond,J.S. and Hansson,G.C. Microbial-induced meprin beta cleavage in MUC2 mucin and a functional CFTR channel are required to release anchored small intestinal mucus Proc Natl Acad Sci U S A (2014) 111, 12396-12401. PubMed Europe PubMed DOI

2013

Broder,C. and Becker-Pauly,C. The metalloproteases meprin alpha and meprin beta: unique enzymes in inflammation, neurodegeneration, cancer and fibrosis Biochem J (2013) 450, 253-264. PubMed Europe PubMed DOI V
Broder,C., Arnold,P., Vadon-Le Goff,S., Konerding,M.A., Bahr,K., Muller,S., Overall,C.M., Bond,J.S., Koudelka,T., Tholey,A., Hulmes,D.J., Moali,C. and Becker-Pauly,C. Metalloproteases meprin alpha and meprin beta are C- and N-procollagen proteinases important for collagen assembly and tensile strength Proc Natl Acad Sci U S A (2013) 110, 14219-14224. PubMed Europe PubMed DOI
Jefferson,T., auf dem Keller,U., Bellac,C., Metz,V.V., Broder,C., Hedrich,J., Ohler,A., Maier,W., Magdolen,V., Sterchi,E., Bond,J.S., Jayakumar,A., Traupe,H., Chalaris,A., Rose-John,S., Pietrzik,C.U., Postina,R., Overall,C.M. and Becker-Pauly,C. The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprinbeta and ADAM10 Cell Mol Life Sci (2013) 70, 309-333. PubMed Europe PubMed DOI P

2012

Arolas,J.L., Broder,C., Jefferson,T., Guevara,T., Sterchi,E.E., Bode,W., Stocker,W., Becker-Pauly,C. and Gomis-Ruth,F.X. Structural basis for the sheddase function of human meprin beta metalloproteinase at the plasma membrane Proc Natl Acad Sci U S A (2012) 109, 16131-16136. PubMed Europe PubMed DOI S
Bertenshaw,G.P. and Bond,J.S. Meprin B [ISSN:978-0-12-407744-7] (2012) 3, 910-916. DOI
Bien,J., Jefferson,T., Causevic,M., Jumpertz,T., Munter,L., Multhaup,G., Weggen,S., Becker-Pauly,C. and Pietrzik,C.U. The metalloprotease meprin beta generates amino terminal-truncated amyloid beta peptide species J Biol Chem (2012) 287, 33304-33313. PubMed Europe PubMed DOI
Geurts,N., Becker-Pauly,C., Martens,E., Proost,P., Van Den Steen,P.E., Stocker,W. and Opdenakker,G. Meprins process matrix metalloproteinase-9 (MMP-9)/gelatinase B and enhance the activation kinetics by MMP-3 FEBS Lett (2012) 586, 4264-4269. PubMed Europe PubMed DOI
Hirano,M., Ma,B.Y., Kawasaki,N., Oka,S. and Kawasaki,T. Role of interaction of mannan-binding protein with meprins at the initial step of complement activation in ischemia/reperfusion injury to mouse kidney Glycobiology (2012) 22, 84-95. PubMed Europe PubMed DOI

2011

Banerjee,S., Jin,G., Bradley,S.G., Matters,G.L., Gailey,R.D., Crisman,J.M. and Bond,J.S. Balance of meprin A and B in mice affects the progression of experimental inflammatory bowel disease Am J Physiol Gastrointest Liver Physiol (2011) 300, G273-G282. PubMed Europe PubMed DOI
Becker-Pauly,C., Barre,O., Schilling,O., auf dem Keller,U., Ohler,A., Broder,C., Schutte,A., Kappelhoff,R., Stocker,W. and Overall,C.M. Proteomic analyses reveal an acidic prime side specificity for the astacin metalloprotease family reflected by physiological substrates Mol Cell Proteomics (2011) 10, M111.009233- PubMed Europe PubMed DOI P
Garcia-Caballero,A., Ishmael,S.S., Dang,Y., Gillie,D., Bond,J.S., Milgram,S.L. and Stutts,M.J. Activation of the epithelial sodium channel by the metalloprotease meprin beta subunit Channels (Austin) (2011) 5, 14-22. PubMed Europe PubMed DOI
Jefferson,T., Causevic,M., auf dem Keller,U., Schilling,O., Isbert,S., Geyer,R., Maier,W., Tschickardt,S., Jumpertz,T., Weggen,S., Bond,J.S., Overall,C.M., Pietrzik,C.U. and Becker-Pauly,C. Metalloprotease meprin beta generates nontoxic N-terminal amyloid precursor protein fragments in vivo J Biol Chem (2011) 286, 27741-27750. PubMed Europe PubMed DOI
Ongeri,E.M., Anyanwu,O., Reeves,W.B. and Bond,J.S. Villin and actin in the mouse kidney brush-border membrane bind to and are degraded by meprins, an interaction that contributes to injury in ischemia-reperfusion Am J Physiol Renal Physiol (2011) 301, F871-F882. PubMed Europe PubMed DOI P
Tsuchiya,S., Simmer,J.P., Hu,J.C., Richardson,A.S., Yamakoshi,F. and Yamakoshi,Y. Astacin proteases cleave dentin sialophosphoprotein (Dspp) to generate dentin phosphoprotein (Dpp) J Bone Miner Res (2011) 26, 220-228. PubMed Europe PubMed DOI P

2010

Ambort,D., Brellier,F., Becker-Pauly,C., Stocker,W., Andrejevic-Blant,S., Chiquet,M. and Sterchi,E.E. Specific processing of tenascin-C by the metalloprotease meprinbeta neutralizes its inhibition of cell spreading Matrix Biol (2010) 29, 31-42. PubMed Europe PubMed DOI P
Hedrich,J., Lottaz,D., Meyer,K., Yiallouros,I., Jahnen-Dechent,W., StoÆ^cker,W. and Becker-Pauly,C. Fetuin-A and cystatin C are endogenous inhibitors of human meprin metalloproteases Biochemistry (2010) 49, 8599-8607. PubMed Europe PubMed DOI
Kronenberg,D., Bruns,B.C., Moali,C., Vadon-Le Goff,S., Sterchi,E.E., Traupe,H., Bohm,M., Hulmes,D.J., Stocker,W. and Becker-Pauly,C. Processing of procollagen III by meprins: new players in extracellular matrix assembly? J Invest Dermatol (2010) 130, 2727-2735. PubMed Europe PubMed DOI P
Ohler,A., Debela,M., Wagner,S., Magdolen,V. and Becker-Pauly,C. Analyzing the protease web in skin: meprin metalloproteases are activated specifically by KLK4, 5 and 8 vice versa leading to processing of proKLK7 thereby triggering its activation Biol Chem (2010) 391, 455-460. PubMed Europe PubMed DOI

2009

Sun,Q., Jin,H.J. and Bond,J.S. Disruption of the meprin alpha and beta genes in mice alters homeostasis of monocytes and natural killer cells Exp Hematol (2009) 37, 346-356. PubMed Europe PubMed DOI PMC EPMC K

2008

Banerjee,S. and Bond,J.S. Prointerleukin-18 is activated by meprin beta in vitro and in vivo in intestinal inflammation J Biol Chem (2008) 283, 31371-31377. PubMed Europe PubMed DOI PMC EPMC
Bylander,J., Li,Q., Ramesh,G., Zhang,B., Reeves,W.B. and Bond,J.S. Targeted disruption of the meprin metalloproteinase beta gene protects against renal ischemia-reperfusion injury in mice Am J Physiol Renal Physiol (2008) 294, F480-F490. PubMed Europe PubMed DOI K
Huguenin,M., Muller,E.J., Trachsel-Rosmann,S., Oneda,B., Ambort,D., Sterchi,E.E. and Lottaz,D. The metalloprotease meprin beta processes E-cadherin and weakens intercellular adhesion PLoS ONE (2008) 3, e2153-e2153. PubMed Europe PubMed DOI PMC EPMC
Oneda,B., Lods,N., Lottaz,D., Becker-Pauly,C., Stocker,W., Pippin,J., Huguenin,M., Ambort,D., Marti,H.P. and Sterchi,E.E. Metalloprotease meprin beta in rat kidney: glomerular localization and differential expression in glomerulonephritis PLoS ONE (2008) 3, e2278-e2278. PubMed Europe PubMed DOI PMC EPMC
Sterchi,E.E., Stocker,W. and Bond,J.S. Meprins, membrane-bound and secreted astacin metalloproteinases Mol Aspects Med (2008) 29, 309-328. PubMed Europe PubMed DOI PMC EPMC V
Yoshimura,H., Ito,M., Kuwahara,Y., Ishii,A., Tsuritani,K., Nakamura,A., Hirasawa,Y. and Nagamatsu,T. Downregulated expression in high IgA (HIGA) mice and the renal protective role of meprinbeta Life Sci (2008) 82, 899-908. PubMed Europe PubMed DOI

2007

Becker-Pauly,C., Howel,M., Walker,T., Vlad,A., Aufenvenne,K., Oji,V., Lottaz,D., Sterchi,E.E., Debela,M., Magdolen,V., Traupe,H. and Stocker,W. The alpha and beta subunits of the metalloprotease meprin are expressed in separate layers of human epidermis, revealing different functions in keratinocyte proliferation and differentiation J Invest Dermatol (2007) 127, 1115-1125. PubMed Europe PubMed DOI
Schutte,A., Lottaz,D., Sterchi,E.E., Stocker,W. and Becker-Pauly,C. Two alpha subunits and one beta subunit of meprin zinc-endopeptidases are differentially expressed in the zebrafish Danio rerio Biol Chem (2007) 388, 523-531. PubMed Europe PubMed DOI

2005

[YEAR:13-6-2005]Bond,J.S., Matters,G.L., Banerjee,S. and Dusheck,R.E. Meprin metalloprotease expression and regulation in kidney, intestine, urinary tract infections and cancer FEBS Lett (13-6-2005) 579, 3317-3322. PubMed Europe PubMed DOI
[YEAR:8-8-2005]Herzog,C., Kaushal,G.P. and Haun,R.S. Generation of biologically active interleukin-1beta by meprin B Cytokine (8-8-2005) 31, 394-403. PubMed Europe PubMed DOI
[YEAR:1-9-2005]Hirano,M., Ma,B.Y., Kawasaki,N., Okimura,K., Baba,M., Nakagawa,T., Miwa,K., Kawasaki,N., Oka,S. and Kawasaki,T. Mannan-binding protein blocks the activation of metalloproteases meprin alpha and beta J Immunol (1-9-2005) 175, 3177-3185. PubMed Europe PubMed
[YEAR:4-2-2005]Ishmael,F.T., Shier,V.K., Ishmael,S.S. and Bond,J.S. Intersubunit and domain interactions of the meprin B metalloproteinase. Disulfide bonds and protein-protein interactions in the MAM and TRAF domains J Biol Chem (4-2-2005) 280, 13895-13901. PubMed Europe PubMed DOI
[YEAR:25-8-2005]Red Eagle,A.R., Hanson,R.L., Jiang,W., Han,X., Matters,G.L., Imperatore,G., Knowler,W.C. and Bond,J.S. Meprin beta metalloprotease gene polymorphisms associated with diabetic nephropathy in the Pima Indians Hum Genet (25-8-2005) 118, 12-22. PubMed Europe PubMed DOI M

2004

Bertenshaw,G.P. and Bond,J.S. Meprin B [ISSN:0-12-079610-4] (2004) 2, 605-609. V
[YEAR:1-4-2004]Crisman,J.M., Zhang,B., Norman,L.P. and Bond,J.S. Deletion of the mouse meprin beta metalloprotease gene diminishes the ability of leukocytes to disseminate through extracellular matrix J Immunol (1-4-2004) 172, 4510-4519. PubMed Europe PubMed
[YEAR:8-6-2004]Hengst,J.A. and Bond,J.S. Transport of meprin subunits through the secretory pathway: role of the transmembrane and cytoplasmic domains and oligomerization J Biol Chem (8-6-2004) 279, 34856-34864. PubMed Europe PubMed DOI
[YEAR:1-3-2004]Kruse,M.N., Becker,C., Lottaz,D., Kohler,D., Yiallouros,I., Krell,H.W., Sterchi,E.E. and Stocker,W. Human meprin alpha and beta homo-oligomers: cleavage of basement membrane proteins and sensitivity to metalloprotease inhibitors Biochem J (1-3-2004) 378, 383-389. PubMed Europe PubMed DOI PMC EPMC I

2003

Becker,C., Kruse,M.N., Slotty,K.A., Kohler,D., Harris,J.R., Rosmann,S., Sterchi,E.E. and Stocker,W. Differences in the activation mechanism between the alpha and beta subunits of human meprin Biol Chem (2003) 384, 825-831. PubMed Europe PubMed DOI
[YEAR:24-1-2003]Bertenshaw,G.P., Norcum,M.T. and Bond,J.S. Structure of homo- and hetero-oligomeric meprin metalloproteases. Dimers, tetramers, and high molecular mass multimers J Biol Chem (24-1-2003) 278, 2522-2532. PubMed Europe PubMed DOI
[YEAR:31-10-2003]Hahn,D., Pischitzis,A., Roesmann,S., Hansen,M.K., Leuenberger,B., Luginbuehl,U. and Sterchi,E.E. Phorbol 12-myristate 13-acetate-induced ectodomain shedding and phosphorylation of the human meprinbeta metalloprotease J Biol Chem (31-10-2003) 278, 42829-42839. PubMed Europe PubMed DOI
[YEAR:1-2-2003]Leuenberger,B., Hahn,D., Pischitzis,A., Hansen,M.K. and Sterchi,E.E. Human meprin beta: O-linked glycans in the intervening region of the type I membrane protein protect the C-terminal region from proteolytic cleavage and diminish its secretion Biochem J (1-2-2003) 369, 659-665. PubMed Europe PubMed DOI PMC EPMC
Norman,L.P., Jiang,W., Han,X., Saunders,T.L. and Bond,J.S. Targeted disruption of the meprin beta gene in mice leads to underrepresentation of knockout mice and changes in renal gene expression profiles Mol Cell Biol (2003) 23, 1221-1230. PubMed Europe PubMed DOI PMC EPMC K
Villa,J.P., Bertenshaw,G.P., Bylander,J.E. and Bond,J.S. Meprin proteolytic complexes at the cell surface and in extracellular spaces Biochem Soc Symp (2003) 2003, 53-63. PubMed Europe PubMed
[YEAR:24-10-2003]Villa,J.P., Bertenshaw,G.P. and Bond,J.S. Critical amino acids in the active site of meprin metalloproteinases for substrate and peptide bond specificity J Biol Chem (24-10-2003) 278, 42545-42550. PubMed Europe PubMed DOI PMC EPMC P

2002

Bertenshaw,G.P., Villa,J.P., Hengst,J.A. and Bond,J.S. Probing the active sites and mechanisms of rat metalloproteases meprin A and B Biol Chem (2002) 383, 1175-1183. PubMed Europe PubMed DOI
[YEAR:13-9-2002]Litovchick,L., Friedmann,E. and Shaltiel,S. A selective interaction between OS-9 and the carboxyl-terminal tail of meprin beta J Biol Chem (13-9-2002) 277, 34413-34423. PubMed Europe PubMed DOI
[YEAR:23-10-2002]Sunnerhagen,M., Pursglove,S. and Fladvad,M. The new MATH: homology suggests shared binding surfaces in meprin tetramers and TRAF trimers FEBS Lett (23-10-2002) 530, 1-3. PubMed Europe PubMed DOI

2001

[YEAR:20-4-2001]Bertenshaw,G.P., Turk,B.E., Hubbard,S.J., Matters,G.L., Bylander,J.E., Crisman,J.M., Cantley,L.C. and Bond,J.S. Marked differences between metalloproteases meprin A and B in substrate and peptide bond specificity J Biol Chem (20-4-2001) 276, 13248-13255. PubMed Europe PubMed DOI

2000

[YEAR:2-5-2000]Jiang,W.P., Kumar,J.M., Matters,G.L. and Bond,J.S. Structure of the mouse metalloprotease meprin beta gene (Mep1b): Alternative splicing in cancer cells Gene (2-5-2000) 248, 77-87. PubMed Europe PubMed DOI
[YEAR:18-8-2000]Kadowaki,T., Tsukuba,T., Bertenshaw,G.P. and Bond,J.S. N-linked oligosaccharides on the meprin A metalloprotease are important for secretion and enzymatic activity, but not for apical targeting J Biol Chem (18-8-2000) 275, 25577-25584. PubMed Europe PubMed DOI

1999

Matters,G.L. and Bond,J.S. Expression and regulation of the meprin beta gene in human cancer cells Mol Carcinog (1999) 25, 169-178. PubMed Europe PubMed DOI
Pischitzis,A., Hahn,D., Leuenberger,B. and Sterchi,E.E. N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase beta (human meprin beta). A 13-amino-acid sequence is required for proteolytic processing and subsequent secretion Eur J Biochem (1999) 261, 421-429. PubMed Europe PubMed DOI

1998

[YEAR:30-10-1998]Litovchick,L., Chestukhin,A. and Shaltiel,S. The carboxyl-terminal tail of kinase splitting membranal proteinase/meprin beta is involved in its intracellular trafficking J Biol Chem (30-10-1998) 273, 29043-29051. PubMed Europe PubMed DOI

1997

Chestukhin,A., Litovchick,L., Muradov,K., Batkin,M. and Shaltiel,S. Unveiling the substrate specificity of meprin beta on the basis of the site in protein kinase A cleaved by the kinase splitting membranal proteinase J Biol Chem (1997) 272, 3153-3160. PubMed Europe PubMed DOI
Eldering,J.A., Grunberg,J., Hahn,D., Croes,H.J., Fransen,J.A. and Sterchi,E.E. Polarised expression of human intestinal N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase (human meprin) alpha and beta subunits in Madin-Darby canine kidney cells Eur J Biochem (1997) 247, 920-932. PubMed Europe PubMed
Hahn,D., Lottaz,D. and Sterchi,E.E. C-cytosolic and transmembrane domains of the N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase alpha subunit (human meprin alpha) are essential for its retention in the endoplasmic reticulum and C-terminal processing Eur J Biochem (1997) 247, 933-941. PubMed Europe PubMed
Johnson,G.D. and Bond,J.S. Activation mechanism of meprins, members of the astacin metalloendopeptidase family J Biol Chem (1997) 272, 28126-28132. PubMed Europe PubMed DOI

1996

Dietrich,J.M., Jiang,W. and Bond,J.S. A novel meprin beta' mRNA in mouse embryonal and human colon carcinoma cells J Biol Chem (1996) 271, 2271-2278. PubMed Europe PubMed DOI

1995

Bond,J.S., Rojas,K., Overhauser,J., Zoghbi,H.Y. and Jiang,W. The structural genes, MEP1A and MEP1B, for the alpha and beta subunits of the metalloendopeptidase meprin map to human chromosomes 6p and 18q, respectively Genomics (1995) 25, 300-303. PubMed Europe PubMed DOI
Wolz,R.L. and Bond,J.S. Meprins A and B Methods Enzymol (1995) 248, 325-345. PubMed Europe PubMed DOI V

1994

[YEAR:11-3-1994]Johnson,G.D. and Hersh,L.B. Expression of meprin subunit precursors. Membrane anchoring through the beta subunit and mechanism of zymogen activation J Biol Chem (11-3-1994) 269, 7682-7688. PubMed Europe PubMed
Marchand,P., Tang,J. and Bond,J.S. Membrane association and oligomeric organization of the alpha and beta subunits of mouse meprin A J Biol Chem (1994) 269, 15388-15393. PubMed Europe PubMed

1993

[YEAR:13-12-1993]Dumermuth,E., Eldering,J.A., Grunberg,J., Jiang,W. and Sterchi,E.E. Cloning of the PABA peptide hydrolase alpha subunit (PPH alpha) from human small intestine and its expression in COS-1 cells FEBS Lett (13-12-1993) 335, 367-375. PubMed Europe PubMed DOI
[YEAR:5-10-1993]Gorbea,C.M., Marchand,P., Jiang,W., Copeland,N.G., Gilbert,D.J., Jenkins,N.A. and Bond,J.S. Cloning, expression, and chromosomal localization of the mouse meprin beta subunit J Biol Chem (5-10-1993) 268, 21035-21043. PubMed Europe PubMed
Grunberg,J., Dumermuth,E., Eldering,J.A. and Sterchi,E.E. Expression of the alpha subunit of PABA peptide hydrolase (EC 3.4.24.18) in MDCK cells. Synthesis and secretion of an enzymatically inactive homodimer FEBS Lett (1993) 335, 376-379. PubMed Europe PubMed DOI

1991

Gorbea,C.M., Flannery,A.V. and Bond,J.S. Homo- and heterotetrameric forms of the membrane-bound metalloendopeptidases meprin A and B Arch Biochem Biophys (1991) 290, 549-553. PubMed Europe PubMed DOI
Kounnas,M.Z., Wolz,R.L., Gorbea,C.M. and Bond,J.S. Meprin-A and -B. Cell surface endopeptidases of the mouse kidney J Biol Chem (1991) 266, 17350-17357. PubMed Europe PubMed

1988

Sterchi,E.E., Naim,H.Y. and Lentze,M.J. Biosynthesis of N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase: disulfide-linked dimers are formed at the site of synthesis in the rough endoplasmic reticulum Arch Biochem Biophys (1988) 265, 119-127. PubMed Europe PubMed
Sterchi,E.E., Naim,H.Y., Lentze,M.J., Hauri,H.P. and Fransen,J.A. N-Benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase: a metalloendopeptidase of the human intestinal microvillus membrane which degrades biologically active peptides Arch Biochem Biophys (1988) 265, 105-118. PubMed Europe PubMed

1986

Stolc,V. Genetics of meprin in the rat J Genet (1986) 65, 13-17. DOI

1984

Bond,J.S., Beynon,R.J., Reckelhoff,J.F. and David,C.S. Mep-1 gene controlling a kidney metalloendopeptidase is linked to the major histocompatibility complex in mice Proc Natl Acad Sci U S A (1984) 81, 5542-5545. PubMed Europe PubMed PMC EPMC