$VAR1 = undef;

Summary for peptidase M12.002: meprin alpha subunit

Names
MEROPS Name	meprin alpha subunit
Other names	endopeptidase 2, MEP1A g.p. (Homo sapiens), meprin-a, meprin A, meprin A alpha component, PABA peptide hydrolase alpha component, N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase alpha component

Domain architecture

MEROPS Classification
Classification	Clan MA >> Subclan MA(M) >> Family M12 >> Subfamily A >> M12.002
Holotype	meprin alpha subunit (Mus musculus), Uniprot accession P28825 (peptidase unit: 71-256), MERNUM MER0001108
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Metallo
Peplist	Included in the Peplist with identifier PL00174
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase 3.4.24.18
Enzymology	BRENDA database
Proteolytic events	CutDB database (9 cleavages)
Activity status	human: active (Bertenshaw & Bond, 2004) mouse: active (Bertenshaw et al., 2001)
Structure	Peptidase unit alpha is one of the two peptidase units, alpha and beta, of meprin A. The peptidase units are present in separate polypeptide chains.
Other databases	TREEFAM	http://www.treefam.org/family/TF315280
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/-/-/-d/-/-/- (based on 776 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	62	57	35	77	43	67	93	76
Pro	34	65	47	4	1	129	101	45
Ala	58	54	76	94	79	61	42	51
Val	33	58	73	5	47	62	68	53
Leu	47	59	96	43	50	50	62	72
Ile	25	45	41	3	25	30	52	47
Met	13	16	20	23	15	15	13	11
Phe	27	30	41	43	25	19	18	28
Tyr	15	14	32	25	17	17	13	11
Trp	8	5	8	15	1	11	3	10
Ser	67	43	45	75	55	47	33	37
Thr	36	37	35	8	64	33	52	42
Cys	9	2	7	3	2	2	5	8
Asn	29	23	22	55	16	15	19	26
Gln	39	36	73	50	12	37	24	33
Asp	42	23	22	74	201	45	31	53
Glu	48	32	44	86	91	83	72	99
Lys	92	87	26	17	9	32	49	44
Arg	61	62	9	41	11	10	10	15
His	17	20	23	35	12	11	13	9