Literature for peptidase M12.002: meprin alpha subunit

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: A Assay, M Mutation, P Specificity, I Inhibitor, K Knockout, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

2026

Okayama,H., Iikura,N., Takakura,D., Abe,S., Sahara,A., Toyoda,S., Kitano,H., Higashi,K., Nakagawa,N., Nonaka,M., Kawasaki,N., Oka,S. and Morise,J. Urinary excretion of nonsulfated HNK-1 glycans is associated with renal dysfunction J Biochem (2026) PubMed Europe PubMed DOI

2023

Bulck,C., Nystrom,E.E.L., Koudelka,T., Mannbar-Frahm,M., Andresen,G., Radhouani,M., Tran,F., Scharfenberg,F., Schrell,F., Armbrust,F., Dahlke,E., Zhao,B., Vervaeke,A., Theilig,F., Rosenstiel,P., Starkl,P., Rosshart,S.P., Fickenscher,H., Tholey,A., Hansson,G.C. and Becker-Pauly,C. Proteolytic processing of galectin-3 by meprin metalloproteases is crucial for host-microbiome homeostasis Sci Adv (2023) 9, eadf4055-eadf4055. PubMed Europe PubMed DOI PMC EPMC

2022

Bayly-Jones,C., Lupton,C.J., Fritz,C., Venugopal,H., Ramsbeck,D., Wermann,M., Jager,C., de Marco,A., Schilling,S., Schlenzig,D. and Whisstock,J.C. Helical ultrastructure of the metalloprotease meprin alpha in complex with a small molecule inhibitor Nat Commun (2022) 13, 6178-6178. PubMed Europe PubMed DOI PMC EPMC

2021

Grainger,A.T., Pilar,N., Li,J., Chen,M.H., Abramson,A.M., Becker-Pauly,C. and Shi,W. Identification of Mep1a as a susceptibility gene for atherosclerosis in mice Genetics (2021) 219 PubMed Europe PubMed DOI PMC EPMC
Hou,S., Diez,J., Wang,C., Becker-Pauly,C., Fields,G.B., Bannister,T., Spicer,T.P., Scampavia,L.D. and Minond,D. Discovery and Optimization of Selective Inhibitors of Meprin alpha (Part I) Pharmaceuticals (Basel) (2021) 14 PubMed Europe PubMed DOI PMC EPMC
Tan,K., Jager,C., Korschgen,H., Geissler,S., Schlenzig,D., Buchholz,M., Stocker,W. and Ramsbeck,D. Heteroaromatic Inhibitors of the Astacin Proteinases Meprin alpha, Meprin beta and Ovastacin Discovered by a Scaffold-Hopping Approach ChemMedChem (2021) 16, 976-988. PubMed Europe PubMed DOI
Werny,L., Colmorgen,C. and Becker-Pauly,C. Regulation of meprin metalloproteases in mucosal homeostasis Biochim Biophys Acta Mol Cell Res (2021) 1869, 119158-119158. PubMed Europe PubMed DOI V

2020

Gao,R., Liu,D., Guo,W., Ge,W., Fan,T., Li,B., Gao,P., Liu,B., Zheng,Y. and Wang,J. Meprin-alpha (Mep1A) enhances TNF-alpha secretion by mast cells and aggravates abdominal aortic aneurysms Br J Pharmacol (2020) 177, 2872-2885. PubMed Europe PubMed DOI

2019

Chaudhuri,A., Biswas,S. and Chakraborty,S. Exploring protein-protein intermolecular recognition between meprin-alpha and endogenous protease regulator cystatin C coupled with pharmacophore elucidation J Biomol Struct Dyn (2019) 37, 440-453. PubMed Europe PubMed DOI
Herzog,C., Haun,R.S. and Kaushal,G.P. Role of meprin metalloproteinases in cytokine processing and inflammation Cytokine (2019) 114, 18-25. PubMed Europe PubMed DOI
Karmilin,K., Schmitz,C., Kuske,M., Korschgen,H., Olf,M., Meyer,K., Hildebrand,A., Felten,M., Fridrich,S., Yiallouros,I., Becker-Pauly,C., Weiskirchen,R., Jahnen-Dechent,W., Floehr,J. and Stocker,W. Mammalian plasma fetuin-B is a selective inhibitor of ovastacin and meprin metalloproteinases Sci Rep (2019) 9, 546-546. PubMed Europe PubMed DOI PMC EPMC
Peters,F., Scharfenberg,F., Colmorgen,C., Armbrust,F., Wichert,R., Arnold,P., Potempa,B., Potempa,J., Pietrzik,C.U., Hasler,R., Rosenstiel,P. and Becker-Pauly,C. Tethering soluble meprin alpha in an enzyme complex to the cell surface affects IBD-associated genes FASEB J (2019) 33, 7490-7504. PubMed Europe PubMed DOI K
Peters,F. and Becker-Pauly,C. Role of meprin metalloproteases in metastasis and tumor microenvironment Cancer Metastasis Rev (2019) 38, 347-356. PubMed Europe PubMed DOI

2018

Biasin,V., Wygrecka,M., Barnthaler,T., Jandl,K., Jain,P.P., Balint,Z., Kovacs,G., Leitinger,G., Kolb-Lenz,D., Kornmueller,K., Peters,F., Sinn,K., Klepetko,W., Heinemann,A., Olschewski,A., Becker-Pauly,C. and Kwapiszewska,G. Docking of meprin alpha to heparan sulphate protects the endothelium from inflammatory cell extravasation Thromb Haemost (2018) 118, 1790-1802. PubMed Europe PubMed DOI
Schulze,A., Wermann,M., Demuth,H.U., Yoshimoto,T., Ramsbeck,D., Schlenzig,D. and Schilling,S. Continuous assays for meprin alpha and beta using prolyl tripeptidyl aminopeptidase (PtP) from Porphyromonas gingivalis Anal Biochem (2018) 559, 11-16. PubMed Europe PubMed DOI A I
Tan,K., Jager,C., Schlenzig,D., Schilling,S., Buchholz,M. and Ramsbeck,D. Tertiary-amine-based inhibitors of the astacin protease meprin alpha ChemMedChem (2018) 13, 1619-1624. PubMed Europe PubMed DOI I

2017

Arnold,P., Koopmann,L., Peters,F., Birkenfeld,F., Goff,S.V., Damm,T., Qin,C., Moali,C., Lucius,R. and Becker-Pauly,C. Deficiency of the DSPP-cleaving enzymes meprin alpha and meprin beta does not result in dentin malformation in mice Cell Tissue Res (2017) 367, 351-358. PubMed Europe PubMed DOI K
Arnold,P., Boll,I., Rothaug,M., Schumacher,N., Schmidt,F., Wichert,R., Schneppenheim,J., Lokau,J., Pickhinke,U., Koudelka,T., Tholey,A., Rabe,B., Scheller,J., Lucius,R., Garbers,C., Rose-John,S. and Becker-Pauly,C. Meprin metalloproteases generate biologically active soluble interleukin-6 receptor to induce trans-signaling Sci Rep (2017) 7, 44053-44053. PubMed Europe PubMed DOI PMC EPMC
Arnold,P., Otte,A. and Becker-Pauly,C. Meprin metalloproteases: molecular regulation and function in inflammation and fibrosis Biochim Biophys Acta (2017) 1864, 2096-2104. PubMed Europe PubMed DOI
Breig,O., Yates,M., Neaud,V., Couchy,G., Grigoletto,A., Lucchesi,C., Prox,J., Zucman-Rossi,J., Becker-Pauly,C. and Rosenbaum,J. Metalloproteinase meprin alpha regulates migration and invasion of human hepatocarcinoma cells and is a mediator of the oncoprotein Reptin Oncotarget (2017) 8, 7839-7851. PubMed Europe PubMed DOI

2016

Chaudhuri,A., Bera,A.K., Sarkar,I. and Chakraborty,S. Insights from analysis of binding sites of human meprins: screening of inhibitors by molecular dynamics simulation study Comb Chem High Throughput Screen (2016) 19, 246-258. PubMed Europe PubMed I
Herzog,C., Haun,R.S., Shah,S.V. and Kaushal,G.P. Proteolytic processing and inactivation of CCL2/MCP-1 by meprins Biochem Biophys Rep (2016) 8, 146-150. PubMed Europe PubMed DOI
Kumar,N., Nakagawa,P., Janic,B., Romero,C.A., Worou,M.E., Monu,S.R., Peterson,E.L., Shaw,J., Valeriote,F., Ongeri,E.M., Niyitegeka,J.M., Rhaleb,N.E. and Carretero,O.A. The anti-inflammatory peptide Ac-SDKP is released from thymosin-beta4 by renal meprin-alpha and prolyl oligopeptidase Am J Physiol Renal Physiol (2016) 310, F1026-F1034. PubMed Europe PubMed DOI
Sato,Y., Kobayashi,D., Kohno,T., Kidani,Y., Prox,J., Becker-Pauly,C. and Hattori,M. Determination of cleavage site of reelin between its sixth and seventh repeat and contribution of meprin metalloproteases to the cleavage J Biochem (2016) 159, 305-312. PubMed Europe PubMed DOI P

2015

Becker-Pauly,C. and Rose-John,S. Meprin and ADAM metalloproteases: two sides of the same coin? Matrix Metalloproteinase Biol (2015) , 115-130. DOI P
Marin,I. Origin and diversification of meprin proteases PLoS ONE (2015) 10, e0135924-e0135924. PubMed Europe PubMed DOI
Niyitegeka,J.M., Bastidas,A.C., Newman,R.H., Taylor,S.S. and Ongeri,E.M. Isoform-specific interactions between meprin metalloproteases and the catalytic subunit of protein kinase A: significance in acute and chronic kidney injury Am J Physiol Renal Physiol (2015) 308, F56-F68. PubMed Europe PubMed DOI
Prox,J., Arnold,P. and Becker-Pauly,C. Meprin alpha and meprin beta: procollagen proteinases in health and disease Matrix Biol (2015) 44-46C, 7-13. PubMed Europe PubMed DOI

2014

Becker-Pauly,C., Broder,C., Prox,J., Koudelka,T. and Tholey,A. Mapping orphan proteases by proteomics: meprin metalloproteases deciphered as potential therapeutic targets Proteomics Clin Appl (2014) 8, 382-388. PubMed Europe PubMed DOI P
Chaudhuri,A., Sarkar,I. and Chakraborty,S. Comparative analysis of binding sites of human meprins with hydroxamic acid derivative by molecular dynamics simulation study J Biomol Struct Dyn (2014) 32, 1969-1978. PubMed Europe PubMed DOI I
Keiffer,T.R. and Bond,J.S. Meprin metalloproteases inactivate interleukin 6 J Biol Chem (2014) 289, 7580-7588. PubMed Europe PubMed DOI
Madoux,F., Tredup,C., Spicer,T.P., Scampavia,L., Chase,P.S., Hodder,P.S., Fields,G.B., Becker-Pauly,C. and Minond,D. Development of high throughput screening assays and pilot screen for inhibitors of metalloproteases meprin alpha and beta Biopolymers (2014) 102, 396-406. PubMed Europe PubMed DOI A

2013

Broder,C. and Becker-Pauly,C. The metalloproteases meprin alpha and meprin beta: unique enzymes in inflammation, neurodegeneration, cancer and fibrosis Biochem J (2013) 450, 253-264. PubMed Europe PubMed DOI V
Broder,C., Arnold,P., Vadon-Le Goff,S., Konerding,M.A., Bahr,K., Muller,S., Overall,C.M., Bond,J.S., Koudelka,T., Tholey,A., Hulmes,D.J., Moali,C. and Becker-Pauly,C. Metalloproteases meprin alpha and meprin beta are C- and N-procollagen proteinases important for collagen assembly and tensile strength Proc Natl Acad Sci U S A (2013) 110, 14219-14224. PubMed Europe PubMed DOI
Jefferson,T., auf dem Keller,U., Bellac,C., Metz,V.V., Broder,C., Hedrich,J., Ohler,A., Maier,W., Magdolen,V., Sterchi,E., Bond,J.S., Jayakumar,A., Traupe,H., Chalaris,A., Rose-John,S., Pietrzik,C.U., Postina,R., Overall,C.M. and Becker-Pauly,C. The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprinbeta and ADAM10 Cell Mol Life Sci (2013) 70, 309-333. PubMed Europe PubMed DOI P
Kaushal,G.P., Haun,R.S., Herzog,C. and Shah,S.V. Meprin A metalloproteinase and its role in acute kidney injury Am J Physiol Renal Physiol (2013) 304, F1150-F1158. PubMed Europe PubMed DOI V

2012

Bertenshaw,G.P. and Bond,J.S. Meprin A [ISSN:978-0-12-407744-7] (2012) 3, 900-910. DOI
Geurts,N., Becker-Pauly,C., Martens,E., Proost,P., Van Den Steen,P.E., Stocker,W. and Opdenakker,G. Meprins process matrix metalloproteinase-9 (MMP-9)/gelatinase B and enhance the activation kinetics by MMP-3 FEBS Lett (2012) 586, 4264-4269. PubMed Europe PubMed DOI
Hirano,M., Ma,B.Y., Kawasaki,N., Oka,S. and Kawasaki,T. Role of interaction of mannan-binding protein with meprins at the initial step of complement activation in ischemia/reperfusion injury to mouse kidney Glycobiology (2012) 22, 84-95. PubMed Europe PubMed DOI
Minder,P., Bayha,E., Becker-Pauly,C. and Sterchi,E.E. Meprinalpha transactivates the epidermal growth factor receptor (EGFR) via ligand shedding, thereby enhancing colorectal cancer cell proliferation and migration J Biol Chem (2012) 287, 35201-35211. PubMed Europe PubMed DOI

2011

Banerjee,S., Jin,G., Bradley,S.G., Matters,G.L., Gailey,R.D., Crisman,J.M. and Bond,J.S. Balance of meprin A and B in mice affects the progression of experimental inflammatory bowel disease Am J Physiol Gastrointest Liver Physiol (2011) 300, G273-G282. PubMed Europe PubMed DOI
Becker-Pauly,C., Barre,O., Schilling,O., auf dem Keller,U., Ohler,A., Broder,C., Schutte,A., Kappelhoff,R., Stocker,W. and Overall,C.M. Proteomic analyses reveal an acidic prime side specificity for the astacin metalloprotease family reflected by physiological substrates Mol Cell Proteomics (2011) 10, M111.009233- PubMed Europe PubMed DOI P
Lottaz,D., Maurer,C.A., Noel,A., Blacher,S., Huguenin,M., Nievergelt,A., Niggli,V., Kern,A., Muller,S., Seibold,F., Friess,H., Becker-Pauly,C., Stocker,W. and Sterchi,E.E. Enhanced activity of meprin-alpha, a pro-migratory and pro-angiogenic protease, in colorectal cancer PLoS ONE (2011) 6, e26450-e26450. PubMed Europe PubMed DOI PMC EPMC
Ongeri,E.M., Anyanwu,O., Reeves,W.B. and Bond,J.S. Villin and actin in the mouse kidney brush-border membrane bind to and are degraded by meprins, an interaction that contributes to injury in ischemia-reperfusion Am J Physiol Renal Physiol (2011) 301, F871-F882. PubMed Europe PubMed DOI P
Tsuchiya,S., Simmer,J.P., Hu,J.C., Richardson,A.S., Yamakoshi,F. and Yamakoshi,Y. Astacin proteases cleave dentin sialophosphoprotein (Dspp) to generate dentin phosphoprotein (Dpp) J Bone Miner Res (2011) 26, 220-228. PubMed Europe PubMed DOI P

2010

Gao,P. and Si,L.Y. Meprin-alpha metalloproteases enhance lipopolysaccharide-stimulated production of tumour necrosis factor-alpha and interleukin-1beta in peripheral blood mononuclear cells via activation of NF-kappaB Regul Pept (2010) 160, 99-105. PubMed Europe PubMed DOI
Hedrich,J., Lottaz,D., Meyer,K., Yiallouros,I., Jahnen-Dechent,W., StoÆ^cker,W. and Becker-Pauly,C. Fetuin-A and cystatin C are endogenous inhibitors of human meprin metalloproteases Biochemistry (2010) 49, 8599-8607. PubMed Europe PubMed DOI
Kronenberg,D., Bruns,B.C., Moali,C., Vadon-Le Goff,S., Sterchi,E.E., Traupe,H., Bohm,M., Hulmes,D.J., Stocker,W. and Becker-Pauly,C. Processing of procollagen III by meprins: new players in extracellular matrix assembly? J Invest Dermatol (2010) 130, 2727-2735. PubMed Europe PubMed DOI P
Ohler,A., Debela,M., Wagner,S., Magdolen,V. and Becker-Pauly,C. Analyzing the protease web in skin: meprin metalloproteases are activated specifically by KLK4, 5 and 8 vice versa leading to processing of proKLK7 thereby triggering its activation Biol Chem (2010) 391, 455-460. PubMed Europe PubMed DOI
Schutte,A., Hedrich,J., Stocker,W. and Becker-Pauly,C. Let it flow: morpholino knockdown in zebrafish embryos reveals a pro-angiogenic effect of the metalloprotease meprin alpha2 PLoS ONE (2010) 5, e8835-e8835. PubMed Europe PubMed DOI PMC EPMC K

2009

Banerjee,S., Oneda,B., Yap,L.M., Jewell,D.P., Matters,G.L., Fitzpatrick,L.R., Seibold,F., Sterchi,E.E., Ahmad,T., Lottaz,D. and Bond,J.S. MEP1A allele for meprin A metalloprotease is a susceptibility gene for inflammatory bowel disease Mucosal Immunol (2009) 2, 220-231. PubMed Europe PubMed DOI PMC EPMC M
Herzog,C., Haun,R.S., Kaushal,V., Mayeux,P.R., Shah,S.V. and Kaushal,G.P. Meprin A and meprin alpha generate biologically functional IL-1beta from pro-IL-1beta Biochem Biophys Res Commun (2009) 379, 904-908. PubMed Europe PubMed DOI
Sun,Q., Jin,H.J. and Bond,J.S. Disruption of the meprin alpha and beta genes in mice alters homeostasis of monocytes and natural killer cells Exp Hematol (2009) 37, 346-356. PubMed Europe PubMed DOI PMC EPMC K

2008

Bergin,D.A., Greene,C.M., Sterchi,E.E., Kenna,C., Geraghty,P., Belaaouaj,A., Taggart,C.C., O'Neill,S.J. and McElvaney,N.G. Activation of the epidermal growth factor receptor (EGFR) by a novel metalloprotease pathway J Biol Chem (2008) 283, 31736-31744. PubMed Europe PubMed DOI
Sterchi,E.E., Stocker,W. and Bond,J.S. Meprins, membrane-bound and secreted astacin metalloproteinases Mol Aspects Med (2008) 29, 309-328. PubMed Europe PubMed DOI PMC EPMC V

2007

Becker-Pauly,C., Howel,M., Walker,T., Vlad,A., Aufenvenne,K., Oji,V., Lottaz,D., Sterchi,E.E., Debela,M., Magdolen,V., Traupe,H. and Stocker,W. The alpha and beta subunits of the metalloprotease meprin are expressed in separate layers of human epidermis, revealing different functions in keratinocyte proliferation and differentiation J Invest Dermatol (2007) 127, 1115-1125. PubMed Europe PubMed DOI
Pankow,K., Wang,Y., Gembardt,F., Krause,E., Sun,X., Krause,G., Schultheiss,H.P., Siems,W.E. and Walther,T. Successive action of meprin A and neprilysin catabolizes B-type natriuretic peptide Circ Res (2007) 101, 875-882. PubMed Europe PubMed DOI
Schutte,A., Lottaz,D., Sterchi,E.E., Stocker,W. and Becker-Pauly,C. Two alpha subunits and one beta subunit of meprin zinc-endopeptidases are differentially expressed in the zebrafish Danio rerio Biol Chem (2007) 388, 523-531. PubMed Europe PubMed DOI

2006

Ishmael,S.S., Ishmael,F.T., Jones,A.D. and Bond,J.S. Protease domain glycans affect oligomerization, disulfide bond formation, and stability of the meprin A metalloprotease homo-oligomer J Biol Chem (2006) 281, 37404-37415. PubMed Europe PubMed DOI

2005

[YEAR:13-6-2005]Bond,J.S., Matters,G.L., Banerjee,S. and Dusheck,R.E. Meprin metalloprotease expression and regulation in kidney, intestine, urinary tract infections and cancer FEBS Lett (13-6-2005) 579, 3317-3322. PubMed Europe PubMed DOI
[YEAR:1-9-2005]Hirano,M., Ma,B.Y., Kawasaki,N., Okimura,K., Baba,M., Nakagawa,T., Miwa,K., Kawasaki,N., Oka,S. and Kawasaki,T. Mannan-binding protein blocks the activation of metalloproteases meprin alpha and beta J Immunol (1-9-2005) 175, 3177-3185. PubMed Europe PubMed
[YEAR:7-6-2005]Mathew,R., Futterweit,S., Valderrama,E., Tarectecan,A.A., Bylander,J.E., Bond,J.S. and Trachtman,H. Meprin-alpha in chronic diabetic nephropathy: interaction with the renin-angiotensin axis Am J Physiol Renal Physiol (7-6-2005) 289, F911-F921. PubMed Europe PubMed DOI
Matters,G.L., Manni,A. and Bond,J.S. Inhibitors of polyamine biosynthesis decrease the expression of the metalloproteases meprin alpha and MMP-7 in hormone-independent human breast cancer cells Clin Exp Metastasis (2005) 22, 331-339. PubMed Europe PubMed DOI I

2004

Bertenshaw,G.P. and Bond,J.S. Meprin A [ISSN:0-12-079610-4] (2004) 2, 599-605. V
DeGuzman,J.B., Speiser,P.W. and Trachtman,H. Urinary meprin-alpha: A potential marker of diabetic nephropathy J Pediatr Endocrinol Metab (2004) 17, 1663-1666. PubMed Europe PubMed
[YEAR:8-6-2004]Hengst,J.A. and Bond,J.S. Transport of meprin subunits through the secretory pathway: role of the transmembrane and cytoplasmic domains and oligomerization J Biol Chem (8-6-2004) 279, 34856-34864. PubMed Europe PubMed DOI
[YEAR:1-3-2004]Kruse,M.N., Becker,C., Lottaz,D., Kohler,D., Yiallouros,I., Krell,H.W., Sterchi,E.E. and Stocker,W. Human meprin alpha and beta homo-oligomers: cleavage of basement membrane proteins and sensitivity to metalloprotease inhibitors Biochem J (1-3-2004) 378, 383-389. PubMed Europe PubMed DOI PMC EPMC I

2003

Becker,C., Kruse,M.N., Slotty,K.A., Kohler,D., Harris,J.R., Rosmann,S., Sterchi,E.E. and Stocker,W. Differences in the activation mechanism between the alpha and beta subunits of human meprin Biol Chem (2003) 384, 825-831. PubMed Europe PubMed DOI
[YEAR:24-1-2003]Bertenshaw,G.P., Norcum,M.T. and Bond,J.S. Structure of homo- and hetero-oligomeric meprin metalloproteases. Dimers, tetramers, and high molecular mass multimers J Biol Chem (24-1-2003) 278, 2522-2532. PubMed Europe PubMed DOI
Villa,J.P., Bertenshaw,G.P., Bylander,J.E. and Bond,J.S. Meprin proteolytic complexes at the cell surface and in extracellular spaces Biochem Soc Symp (2003) 2003, 53-63. PubMed Europe PubMed
[YEAR:24-10-2003]Villa,J.P., Bertenshaw,G.P. and Bond,J.S. Critical amino acids in the active site of meprin metalloproteinases for substrate and peptide bond specificity J Biol Chem (24-10-2003) 278, 42545-42550. PubMed Europe PubMed DOI PMC EPMC P

2002

Bertenshaw,G.P., Villa,J.P., Hengst,J.A. and Bond,J.S. Probing the active sites and mechanisms of rat metalloproteases meprin A and B Biol Chem (2002) 383, 1175-1183. PubMed Europe PubMed DOI
Doll,B.A., Villa,J.P., Ishmael,F.T. and Bond,J.S. Zinc ligands in an astacin family metalloprotease meprin A Biol Chem (2002) 383, 1167-1173. PubMed Europe PubMed DOI
[YEAR:25-10-2002]Rosmann,S., Hahn,D., Lottaz,D., Kruse,M.N., Stocker,W. and Sterchi,E.E. Activation of human meprin-alpha in a cell culture model of colorectal cancer is triggered by the plasminogen-activating system J Biol Chem (25-10-2002) 277, 40650-40658. PubMed Europe PubMed DOI
[YEAR:23-10-2002]Sunnerhagen,M., Pursglove,S. and Fladvad,M. The new MATH: homology suggests shared binding surfaces in meprin tetramers and TRAF trimers FEBS Lett (23-10-2002) 530, 1-3. PubMed Europe PubMed DOI

2001

[YEAR:20-4-2001]Bertenshaw,G.P., Turk,B.E., Hubbard,S.J., Matters,G.L., Bylander,J.E., Crisman,J.M., Cantley,L.C. and Bond,J.S. Marked differences between metalloproteases meprin A and B in substrate and peptide bond specificity J Biol Chem (20-4-2001) 276, 13248-13255. PubMed Europe PubMed DOI

2000

[YEAR:15-2-2000]Hahn,D., Illisson,R., Metspalu,A. and Sterchi,E.E. Human N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase (human meprin): genomic structure of the alpha and beta subunits Biochem J (15-2-2000) 346, 83-91. PubMed Europe PubMed DOI PMC EPMC
[YEAR:15-7-2000]Jiang,W.P. and Le,B. Structure and expression of the human MEP1A gene encoding the alpha subunit of metalloendopeptidase meprin A Arch Biochem Biophys (15-7-2000) 379, 183-187. PubMed Europe PubMed DOI
[YEAR:18-8-2000]Kadowaki,T., Tsukuba,T., Bertenshaw,G.P. and Bond,J.S. N-linked oligosaccharides on the meprin A metalloprotease are important for secretion and enzymatic activity, but not for apical targeting J Biol Chem (18-8-2000) 275, 25577-25584. PubMed Europe PubMed DOI
[YEAR:7-1-2000]Kohler,D., Kruse,M., Stocker,W. and Sterchi,E.E. Heterologously overexpressed, affinity-purified human meprin alpha is functionally active and cleaves components of the basement membrane in vitro FEBS Lett (7-1-2000) 465, 2-7. PubMed Europe PubMed DOI E

1999

Lottaz,D., Hahn,D., Muller,S., Muller,C. and Sterchi,E.E. Secretion of human meprin from intestinal epithelial cells depends on differential expression of the alpha and beta subunits Eur J Biochem (1999) 259, 496-504. PubMed Europe PubMed DOI

1998

[YEAR:1-1-1998]Tang,J. and Bond,J.S. Maturation of secreted meprin alpha during biosynthesis: Role of the furin site and identification of the COOH-terminal amino acids of the mouse kidney metalloprotease subunit Arch Biochem Biophys (1-1-1998) 349, 192-200. PubMed Europe PubMed DOI
[YEAR:25-12-1998]Tsukuba,T. and Bond,J.S. Role of the COOH-terminal domains of meprin A in folding, secretion, and activity of the metalloendopeptidase J Biol Chem (25-12-1998) 273, 35260-35267. PubMed Europe PubMed DOI
Walker,P.D., Kaushal,G.P. and Shah,S.V. Meprin A, the major matrix degrading enzyme in renal tubules, produces a novel nidogen fragment in vitro and in vivo Kidney Int (1998) 53, 1673-1680. PubMed Europe PubMed DOI

1997

Jiang,W. and Beatty,B.G. Assignment of Mep 1a to mouse chromosome band 17C1-D1 by in situ hybridization Cytogenet Cell Genet (1997) 76, 206-207. PubMed Europe PubMed
Jiang,W. and Flannery,A.V. Correlation of the exon/intron organization to the secondary structures of the protease domain of mouse meprin alpha subunit Gene (1997) 189, 65-71. PubMed Europe PubMed DOI
Johnson,G.D. and Bond,J.S. Activation mechanism of meprins, members of the astacin metalloendopeptidase family J Biol Chem (1997) 272, 28126-28132. PubMed Europe PubMed DOI

1996

Bankus,J.M. and Bond,J.S. Expression and distribution of meprin protease subunits in mouse intestine Arch Biochem Biophys (1996) 331, 87-94. PubMed Europe PubMed DOI
Beynon,R.J., Oliver,S. and Robertson,D.H. Characterization of the soluble, secreted form of urinary meprin Biochem J (1996) 315, 461-465. PubMed Europe PubMed PMC EPMC
Dewald,G., Schildhaus,H.U., Mucher,G. and Zerres,K. A HhaI polymorphism in the human MEP1A gene encoding the alpha subunit of the metalloendopeptidase meprin Hum Hered (1996) 46, 298-300. PubMed Europe PubMed M

1995

Bond,J.S., Rojas,K., Overhauser,J., Zoghbi,H.Y. and Jiang,W. The structural genes, MEP1A and MEP1B, for the alpha and beta subunits of the metalloendopeptidase meprin map to human chromosomes 6p and 18q, respectively Genomics (1995) 25, 300-303. PubMed Europe PubMed DOI
Trachtman,H., Valderrama,E., Dietrich,J.M. and Bond,J.S. The role of Meprin A in the pathogenesis of acute renal failure Biochem Biophys Res Commun (1995) 208, 498-505. PubMed Europe PubMed DOI
Wolz,R.L. and Bond,J.S. Meprins A and B Methods Enzymol (1995) 248, 325-345. PubMed Europe PubMed DOI V
Yamaguchi,T., Fukase,M., Sugimoto,T. and Chihara,K. Hydrolysis of a carboxy-terminal fragment of parathyroid hormone-related protein by rat kidney: evidence for a crucial role of meprin Horm Metab Res (1995) 27, 131-136. PubMed Europe PubMed DOI

1994

[YEAR:11-3-1994]Johnson,G.D. and Hersh,L.B. Expression of meprin subunit precursors. Membrane anchoring through the beta subunit and mechanism of zymogen activation J Biol Chem (11-3-1994) 269, 7682-7688. PubMed Europe PubMed
Marchand,P., Tang,J. and Bond,J.S. Membrane association and oligomeric organization of the alpha and beta subunits of mouse meprin A J Biol Chem (1994) 269, 15388-15393. PubMed Europe PubMed
Wolz,R.L. A kinetic comparison of the homologous proteases astacin and meprin A Arch Biochem Biophys (1994) 310, 144-151. PubMed Europe PubMed DOI I

1993

[YEAR:5-10-1993]Gorbea,C.M., Marchand,P., Jiang,W., Copeland,N.G., Gilbert,D.J., Jenkins,N.A. and Bond,J.S. Cloning, expression, and chromosomal localization of the mouse meprin beta subunit J Biol Chem (5-10-1993) 268, 21035-21043. PubMed Europe PubMed

1992

Corbeil,D., Gaudoux,F., Wainwright,S., Ingram,J., Kenny,A.J., Boileau,G. and Crine,P. Molecular cloning of the alpha-subunit of rat endopeptidase- 24.18 (endopeptidase-2) and co-localization with endopeptidase- 24.11 in rat kidney by in situ hybridization FEBS Lett (1992) 309, 203-208. PubMed Europe PubMed DOI
Johnson,G.D. and Hersh,L.B. Cloning a rat meprin cDNA reveals the enzyme is a heterodimer J Biol Chem (1992) 267, 13505-13512. PubMed Europe PubMed

1991

Gorbea,C.M., Flannery,A.V. and Bond,J.S. Homo- and heterotetrameric forms of the membrane-bound metalloendopeptidases meprin A and B Arch Biochem Biophys (1991) 290, 549-553. PubMed Europe PubMed DOI
Kounnas,M.Z., Wolz,R.L., Gorbea,C.M. and Bond,J.S. Meprin-A and -B. Cell surface endopeptidases of the mouse kidney J Biol Chem (1991) 266, 17350-17357. PubMed Europe PubMed

1989

Barnes,K., Ingram,J. and Kenny,A.J. Proteins of the kidney microvillar membrane. Structural and immunochemical properties of rat endopeptidase-2 and its immunohistochemical localization in tissues of rat and mouse Biochem J (1989) 264, 335-346. PubMed Europe PubMed PMC EPMC

1988

Butler,P.E. and Bond,J.S. A latent proteinase in mouse kidney membranes. Characterization and relationship to meprin J Biol Chem (1988) 263, 13419-13426. PubMed Europe PubMed
Stephenson,S.L. and Kenny,A.J. The metabolism of neuropeptides. Hydrolysis of peptides by the phosphoramidon-insensitive rat kidney enzyme 'endopeptidase-2' and by rat microvillar membranes Biochem J (1988) 255, 45-51. PubMed Europe PubMed PMC EPMC I

1987

Butler,P.E., McKay,M.J. and Bond,J.S. Characterization of meprin, a membrane-bound metalloendopeptidase from mouse kidney Biochem J (1987) 241, 229-235. PubMed Europe PubMed PMC EPMC

1986

Stolc,V. Genetics of meprin in the rat J Genet (1986) 65, 13-17. DOI

1981

Beynon,R.J., Shannon,J.D. and Bond,J.S. Purification and characterization of a metallo-endoproteinase from mouse kidney Biochem J (1981) 199, 591-598. PubMed Europe PubMed PMC EPMC