Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Literature for peptidase M12.002: meprin alpha subunit

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: A Assay, M Mutation, P Specificity, I Inhibitor, K Knockout, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2023
  1. Bulck,C., Nystrom,E.E.L., Koudelka,T., Mannbar-Frahm,M., Andresen,G., Radhouani,M., Tran,F., Scharfenberg,F., Schrell,F., Armbrust,F., Dahlke,E., Zhao,B., Vervaeke,A., Theilig,F., Rosenstiel,P., Starkl,P., Rosshart,S.P., Fickenscher,H., Tholey,A., Hansson,G.C. and Becker-Pauly,C.
    Proteolytic processing of galectin-3 by meprin metalloproteases is crucial for host-microbiome homeostasis
    Sci Adv9, eadf4055-eadf4055. PubMed  Europe PubMed DOI
    2. 2022
  2. Bayly-Jones,C., Lupton,C.J., Fritz,C., Venugopal,H., Ramsbeck,D., Wermann,M., Jager,C., de Marco,A., Schilling,S., Schlenzig,D. and Whisstock,J.C.
    Helical ultrastructure of the metalloprotease meprin alpha in complex with a small molecule inhibitor
    Nat Commun13, 6178-6178. PubMed  Europe PubMed DOI
    3. 2021
  3. Grainger,A.T., Pilar,N., Li,J., Chen,M.H., Abramson,A.M., Becker-Pauly,C. and Shi,W.
    Identification of Mep1a as a susceptibility gene for atherosclerosis in mice
    Genetics219, PubMed  Europe PubMed DOI
  4. Hou,S., Diez,J., Wang,C., Becker-Pauly,C., Fields,G.B., Bannister,T., Spicer,T.P., Scampavia,L.D. and Minond,D.
    Discovery and Optimization of Selective Inhibitors of Meprin alpha (Part I)
    Pharmaceuticals (Basel)14, PubMed  Europe PubMed DOI
  5. Tan,K., Jager,C., Korschgen,H., Geissler,S., Schlenzig,D., Buchholz,M., Stocker,W. and Ramsbeck,D.
    Heteroaromatic Inhibitors of the Astacin Proteinases Meprin alpha, Meprin beta and Ovastacin Discovered by a Scaffold-Hopping Approach
    ChemMedChem16, 976-988. PubMed  Europe PubMed DOI
  6. Werny,L., Colmorgen,C. and Becker-Pauly,C.
    Regulation of meprin metalloproteases in mucosal homeostasis
    Biochim Biophys Acta Mol Cell Res1869, 119158-119158. PubMed  Europe PubMed DOI  V
    7. 2020
  7. Gao,R., Liu,D., Guo,W., Ge,W., Fan,T., Li,B., Gao,P., Liu,B., Zheng,Y. and Wang,J.
    Meprin-alpha (Mep1A) enhances TNF-alpha secretion by mast cells and aggravates abdominal aortic aneurysms
    Br J Pharmacol177, 2872-2885. PubMed  Europe PubMed DOI
    8. 2019
  8. Chaudhuri,A., Biswas,S. and Chakraborty,S.
    Exploring protein-protein intermolecular recognition between meprin-alpha and endogenous protease regulator cystatin C coupled with pharmacophore elucidation
    J Biomol Struct Dyn37, 440-453. PubMed  Europe PubMed DOI
  9. Herzog,C., Haun,R.S. and Kaushal,G.P.
    Role of meprin metalloproteinases in cytokine processing and inflammation
    Cytokine114, 18-25. PubMed  Europe PubMed DOI
  10. Karmilin,K., Schmitz,C., Kuske,M., Korschgen,H., Olf,M., Meyer,K., Hildebrand,A., Felten,M., Fridrich,S., Yiallouros,I., Becker-Pauly,C., Weiskirchen,R., Jahnen-Dechent,W., Floehr,J. and Stocker,W.
    Mammalian plasma fetuin-B is a selective inhibitor of ovastacin and meprin metalloproteinases
    Sci Rep9, 546-546. PubMed  Europe PubMed DOI
  11. Peters,F. and Becker-Pauly,C.
    Role of meprin metalloproteases in metastasis and tumor microenvironment
    Cancer Metastasis Rev38, 347-356. PubMed  Europe PubMed DOI
  12. Peters,F., Scharfenberg,F., Colmorgen,C., Armbrust,F., Wichert,R., Arnold,P., Potempa,B., Potempa,J., Pietrzik,C.U., Hasler,R., Rosenstiel,P. and Becker-Pauly,C.
    Tethering soluble meprin alpha in an enzyme complex to the cell surface affects IBD-associated genes
    FASEB J33, 7490-7504. PubMed  Europe PubMed DOI  K
    13. 2018
  13. Biasin,V., Wygrecka,M., Barnthaler,T., Jandl,K., Jain,P.P., Balint,Z., Kovacs,G., Leitinger,G., Kolb-Lenz,D., Kornmueller,K., Peters,F., Sinn,K., Klepetko,W., Heinemann,A., Olschewski,A., Becker-Pauly,C. and Kwapiszewska,G.
    Docking of meprin alpha to heparan sulphate protects the endothelium from inflammatory cell extravasation
    Thromb Haemost118, 1790-1802. PubMed  Europe PubMed DOI
  14. Schulze,A., Wermann,M., Demuth,H.U., Yoshimoto,T., Ramsbeck,D., Schlenzig,D. and Schilling,S.
    Continuous assays for meprin alpha and beta using prolyl tripeptidyl aminopeptidase (PtP) from Porphyromonas gingivalis
    Anal Biochem559, 11-16. PubMed  Europe PubMed DOI  A  I
  15. Tan,K., Jager,C., Schlenzig,D., Schilling,S., Buchholz,M. and Ramsbeck,D.
    Tertiary-amine-based inhibitors of the astacin protease meprin alpha
    ChemMedChem13, 1619-1624. PubMed  Europe PubMed DOI  I
    16. 2017
  16. Arnold,P., Otte,A. and Becker-Pauly,C.
    Meprin metalloproteases: molecular regulation and function in inflammation and fibrosis
    Biochim Biophys Acta1864, 2096-2104. PubMed  Europe PubMed DOI
  17. Arnold,P., Boll,I., Rothaug,M., Schumacher,N., Schmidt,F., Wichert,R., Schneppenheim,J., Lokau,J., Pickhinke,U., Koudelka,T., Tholey,A., Rabe,B., Scheller,J., Lucius,R., Garbers,C., Rose-John,S. and Becker-Pauly,C.
    Meprin metalloproteases generate biologically active soluble interleukin-6 receptor to induce trans-signaling
    Sci Rep7, 44053-44053. PubMed  Europe PubMed DOI
  18. Arnold,P., Koopmann,L., Peters,F., Birkenfeld,F., Goff,S.V., Damm,T., Qin,C., Moali,C., Lucius,R. and Becker-Pauly,C.
    Deficiency of the DSPP-cleaving enzymes meprin alpha and meprin beta does not result in dentin malformation in mice
    Cell Tissue Res367, 351-358. PubMed  Europe PubMed DOI  K
  19. Breig,O., Yates,M., Neaud,V., Couchy,G., Grigoletto,A., Lucchesi,C., Prox,J., Zucman-Rossi,J., Becker-Pauly,C. and Rosenbaum,J.
    Metalloproteinase meprin alpha regulates migration and invasion of human hepatocarcinoma cells and is a mediator of the oncoprotein Reptin
    Oncotarget8, 7839-7851. PubMed  Europe PubMed DOI
    20. 2016
  20. Chaudhuri,A., Bera,A.K., Sarkar,I. and Chakraborty,S.
    Insights from analysis of binding sites of human meprins: screening of inhibitors by molecular dynamics simulation study
    Comb Chem High Throughput Screen19, 246-258. PubMed  Europe PubMed  I
  21. Herzog,C., Haun,R.S., Shah,S.V. and Kaushal,G.P.
    Proteolytic processing and inactivation of CCL2/MCP-1 by meprins
    Biochem Biophys Rep8, 146-150. PubMed  Europe PubMed DOI
  22. Kumar,N., Nakagawa,P., Janic,B., Romero,C.A., Worou,M.E., Monu,S.R., Peterson,E.L., Shaw,J., Valeriote,F., Ongeri,E.M., Niyitegeka,J.M., Rhaleb,N.E. and Carretero,O.A.
    The anti-inflammatory peptide Ac-SDKP is released from thymosin-beta4 by renal meprin-alpha and prolyl oligopeptidase
    Am J Physiol Renal Physiol310, F1026-F1034. PubMed  Europe PubMed DOI
  23. Sato,Y., Kobayashi,D., Kohno,T., Kidani,Y., Prox,J., Becker-Pauly,C. and Hattori,M.
    Determination of cleavage site of reelin between its sixth and seventh repeat and contribution of meprin metalloproteases to the cleavage
    J Biochem159, 305-312. PubMed  Europe PubMed DOI  P
    24. 2015
  24. Becker-Pauly,C. and Rose-John,S.
    Meprin and ADAM metalloproteases: two sides of the same coin?
    Matrix Metalloproteinase Biol115-130. DOI  P
  25. Marin,I.
    Origin and diversification of meprin proteases
    PLoS ONE10, e0135924-e0135924. PubMed  Europe PubMed DOI
  26. Niyitegeka,J.M., Bastidas,A.C., Newman,R.H., Taylor,S.S. and Ongeri,E.M.
    Isoform-specific interactions between meprin metalloproteases and the catalytic subunit of protein kinase A: significance in acute and chronic kidney injury
    Am J Physiol Renal Physiol308, F56-F68. PubMed  Europe PubMed DOI
  27. Prox,J., Arnold,P. and Becker-Pauly,C.
    Meprin alpha and meprin beta: procollagen proteinases in health and disease
    Matrix Biol44-46C, 7-13. PubMed  Europe PubMed DOI
    28. 2014
  28. Becker-Pauly,C., Broder,C., Prox,J., Koudelka,T. and Tholey,A.
    Mapping orphan proteases by proteomics: meprin metalloproteases deciphered as potential therapeutic targets
    Proteomics Clin Appl8, 382-388. PubMed  Europe PubMed DOI  P
  29. Chaudhuri,A., Sarkar,I. and Chakraborty,S.
    Comparative analysis of binding sites of human meprins with hydroxamic acid derivative by molecular dynamics simulation study
    J Biomol Struct Dyn32, 1969-1978. PubMed  Europe PubMed DOI  I
  30. Keiffer,T.R. and Bond,J.S.
    Meprin metalloproteases inactivate interleukin 6
    J Biol Chem289, 7580-7588. PubMed  Europe PubMed DOI
  31. Madoux,F., Tredup,C., Spicer,T.P., Scampavia,L., Chase,P.S., Hodder,P.S., Fields,G.B., Becker-Pauly,C. and Minond,D.
    Development of high throughput screening assays and pilot screen for inhibitors of metalloproteases meprin alpha and beta
    Biopolymers102, 396-406. PubMed  Europe PubMed DOI  A
    32. 2013
  32. Broder,C. and Becker-Pauly,C.
    The metalloproteases meprin alpha and meprin beta: unique enzymes in inflammation, neurodegeneration, cancer and fibrosis
    Biochem J450, 253-264. PubMed  Europe PubMed DOI  V
  33. Broder,C., Arnold,P., Vadon-Le Goff,S., Konerding,M.A., Bahr,K., Muller,S., Overall,C.M., Bond,J.S., Koudelka,T., Tholey,A., Hulmes,D.J., Moali,C. and Becker-Pauly,C.
    Metalloproteases meprin alpha and meprin beta are C- and N-procollagen proteinases important for collagen assembly and tensile strength
    Proc Natl Acad Sci U S A110, 14219-14224. PubMed  Europe PubMed DOI
  34. Jefferson,T., auf dem Keller,U., Bellac,C., Metz,V.V., Broder,C., Hedrich,J., Ohler,A., Maier,W., Magdolen,V., Sterchi,E., Bond,J.S., Jayakumar,A., Traupe,H., Chalaris,A., Rose-John,S., Pietrzik,C.U., Postina,R., Overall,C.M. and Becker-Pauly,C.
    The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprinbeta and ADAM10
    Cell Mol Life Sci70, 309-333. PubMed  Europe PubMed DOI  P
  35. Kaushal,G.P., Haun,R.S., Herzog,C. and Shah,S.V.
    Meprin A metalloproteinase and its role in acute kidney injury
    Am J Physiol Renal Physiol304, F1150-F1158. PubMed  Europe PubMed DOI  V
    36. 2012
  36. Bertenshaw,G.P. and Bond,J.S.
    Meprin A
    [ISSN:978-0-12-407744-7]3, 900-910. DOI
  37. Geurts,N., Becker-Pauly,C., Martens,E., Proost,P., Van Den Steen,P.E., Stocker,W. and Opdenakker,G.
    Meprins process matrix metalloproteinase-9 (MMP-9)/gelatinase B and enhance the activation kinetics by MMP-3
    FEBS Lett586, 4264-4269. PubMed  Europe PubMed DOI
  38. Hirano,M., Ma,B.Y., Kawasaki,N., Oka,S. and Kawasaki,T.
    Role of interaction of mannan-binding protein with meprins at the initial step of complement activation in ischemia/reperfusion injury to mouse kidney
    Glycobiology22, 84-95. PubMed  Europe PubMed DOI
  39. Minder,P., Bayha,E., Becker-Pauly,C. and Sterchi,E.E.
    Meprinalpha transactivates the epidermal growth factor receptor (EGFR) via ligand shedding, thereby enhancing colorectal cancer cell proliferation and migration
    J Biol Chem287, 35201-35211. PubMed  Europe PubMed DOI
    40. 2011
  40. Banerjee,S., Jin,G., Bradley,S.G., Matters,G.L., Gailey,R.D., Crisman,J.M. and Bond,J.S.
    Balance of meprin A and B in mice affects the progression of experimental inflammatory bowel disease
    Am J Physiol Gastrointest Liver Physiol300, G273-G282. PubMed  Europe PubMed DOI
  41. Becker-Pauly,C., Barre,O., Schilling,O., auf dem Keller,U., Ohler,A., Broder,C., Schutte,A., Kappelhoff,R., Stocker,W. and Overall,C.M.
    Proteomic analyses reveal an acidic prime side specificity for the astacin metalloprotease family reflected by physiological substrates
    Mol Cell Proteomics10, M111.009233- PubMed  Europe PubMed DOI  P
  42. Lottaz,D., Maurer,C.A., Noel,A., Blacher,S., Huguenin,M., Nievergelt,A., Niggli,V., Kern,A., Muller,S., Seibold,F., Friess,H., Becker-Pauly,C., Stocker,W. and Sterchi,E.E.
    Enhanced activity of meprin-alpha, a pro-migratory and pro-angiogenic protease, in colorectal cancer
    PLoS ONE6, e26450-e26450. PubMed  Europe PubMed DOI
  43. Ongeri,E.M., Anyanwu,O., Reeves,W.B. and Bond,J.S.
    Villin and actin in the mouse kidney brush-border membrane bind to and are degraded by meprins, an interaction that contributes to injury in ischemia-reperfusion
    Am J Physiol Renal Physiol301, F871-F882. PubMed  Europe PubMed DOI  P
  44. Tsuchiya,S., Simmer,J.P., Hu,J.C., Richardson,A.S., Yamakoshi,F. and Yamakoshi,Y.
    Astacin proteases cleave dentin sialophosphoprotein (Dspp) to generate dentin phosphoprotein (Dpp)
    J Bone Miner Res26, 220-228. PubMed  Europe PubMed DOI  P
    45. 2010
  45. Gao,P. and Si,L.Y.
    Meprin-alpha metalloproteases enhance lipopolysaccharide-stimulated production of tumour necrosis factor-alpha and interleukin-1beta in peripheral blood mononuclear cells via activation of NF-kappaB
    Regul Pept160, 99-105. PubMed  Europe PubMed DOI
  46. Hedrich,J., Lottaz,D., Meyer,K., Yiallouros,I., Jahnen-Dechent,W., StoÆ^cker,W. and Becker-Pauly,C.
    Fetuin-A and cystatin C are endogenous inhibitors of human meprin metalloproteases
    Biochemistry49, 8599-8607. PubMed  Europe PubMed DOI
  47. Kronenberg,D., Bruns,B.C., Moali,C., Vadon-Le Goff,S., Sterchi,E.E., Traupe,H., Bohm,M., Hulmes,D.J., Stocker,W. and Becker-Pauly,C.
    Processing of procollagen III by meprins: new players in extracellular matrix assembly?
    J Invest Dermatol130, 2727-2735. PubMed  Europe PubMed DOI  P
  48. Ohler,A., Debela,M., Wagner,S., Magdolen,V. and Becker-Pauly,C.
    Analyzing the protease web in skin: meprin metalloproteases are activated specifically by KLK4, 5 and 8 vice versa leading to processing of proKLK7 thereby triggering its activation
    Biol Chem391, 455-460. PubMed  Europe PubMed DOI
  49. Schutte,A., Hedrich,J., Stocker,W. and Becker-Pauly,C.
    Let it flow: morpholino knockdown in zebrafish embryos reveals a pro-angiogenic effect of the metalloprotease meprin alpha2
    PLoS ONE5, e8835-e8835. PubMed  Europe PubMed DOI  K
    50. 2009
  50. Banerjee,S., Oneda,B., Yap,L.M., Jewell,D.P., Matters,G.L., Fitzpatrick,L.R., Seibold,F., Sterchi,E.E., Ahmad,T., Lottaz,D. and Bond,J.S.
    MEP1A allele for meprin A metalloprotease is a susceptibility gene for inflammatory bowel disease
    Mucosal Immunol2, 220-231. PubMed  Europe PubMed DOI  M
  51. Herzog,C., Haun,R.S., Kaushal,V., Mayeux,P.R., Shah,S.V. and Kaushal,G.P.
    Meprin A and meprin alpha generate biologically functional IL-1beta from pro-IL-1beta
    Biochem Biophys Res Commun379, 904-908. PubMed  Europe PubMed DOI
  52. Sun,Q., Jin,H.J. and Bond,J.S.
    Disruption of the meprin alpha and beta genes in mice alters homeostasis of monocytes and natural killer cells
    Exp Hematol37, 346-356. PubMed  Europe PubMed DOI  K
    53. 2008
  53. Bergin,D.A., Greene,C.M., Sterchi,E.E., Kenna,C., Geraghty,P., Belaaouaj,A., Taggart,C.C., O'Neill,S.J. and McElvaney,N.G.
    Activation of the epidermal growth factor receptor (EGFR) by a novel metalloprotease pathway
    J Biol Chem283, 31736-31744. PubMed  Europe PubMed DOI
  54. Sterchi,E.E., Stocker,W. and Bond,J.S.
    Meprins, membrane-bound and secreted astacin metalloproteinases
    Mol Aspects Med29, 309-328. PubMed  Europe PubMed DOI  V
    55. 2007
  55. Becker-Pauly,C., Howel,M., Walker,T., Vlad,A., Aufenvenne,K., Oji,V., Lottaz,D., Sterchi,E.E., Debela,M., Magdolen,V., Traupe,H. and Stocker,W.
    The alpha and beta subunits of the metalloprotease meprin are expressed in separate layers of human epidermis, revealing different functions in keratinocyte proliferation and differentiation
    J Invest Dermatol127, 1115-1125. PubMed  Europe PubMed DOI
  56. Pankow,K., Wang,Y., Gembardt,F., Krause,E., Sun,X., Krause,G., Schultheiss,H.P., Siems,W.E. and Walther,T.
    Successive action of meprin A and neprilysin catabolizes B-type natriuretic peptide
    Circ Res101, 875-882. PubMed  Europe PubMed DOI
  57. Schutte,A., Lottaz,D., Sterchi,E.E., Stocker,W. and Becker-Pauly,C.
    Two alpha subunits and one beta subunit of meprin zinc-endopeptidases are differentially expressed in the zebrafish Danio rerio
    Biol Chem388, 523-531. PubMed  Europe PubMed DOI
    58. 2006
  58. Ishmael,S.S., Ishmael,F.T., Jones,A.D. and Bond,J.S.
    Protease domain glycans affect oligomerization, disulfide bond formation, and stability of the meprin A metalloprotease homo-oligomer
    J Biol Chem281, 37404-37415. PubMed  Europe PubMed DOI
    59. 2005
  59. [YEAR:13-6-2005]Bond,J.S., Matters,G.L., Banerjee,S. and Dusheck,R.E.
    Meprin metalloprotease expression and regulation in kidney, intestine, urinary tract infections and cancer
    FEBS Lett579, 3317-3322. PubMed  Europe PubMed DOI
  60. [YEAR:1-9-2005]Hirano,M., Ma,B.Y., Kawasaki,N., Okimura,K., Baba,M., Nakagawa,T., Miwa,K., Kawasaki,N., Oka,S. and Kawasaki,T.
    Mannan-binding protein blocks the activation of metalloproteases meprin alpha and beta
    J Immunol175, 3177-3185. PubMed  Europe PubMed
  61. [YEAR:7-6-2005]Mathew,R., Futterweit,S., Valderrama,E., Tarectecan,A.A., Bylander,J.E., Bond,J.S. and Trachtman,H.
    Meprin-alpha in chronic diabetic nephropathy: interaction with the renin-angiotensin axis
    Am J Physiol Renal Physiol289, F911-F921. PubMed  Europe PubMed DOI
  62. Matters,G.L., Manni,A. and Bond,J.S.
    Inhibitors of polyamine biosynthesis decrease the expression of the metalloproteases meprin alpha and MMP-7 in hormone-independent human breast cancer cells
    Clin Exp Metastasis22, 331-339. PubMed  Europe PubMed DOI  I
    63. 2004
  63. Bertenshaw,G.P. and Bond,J.S.
    Meprin A
    [ISSN:0-12-079610-4]2, 599-605.  V
  64. DeGuzman,J.B., Speiser,P.W. and Trachtman,H.
    Urinary meprin-alpha: A potential marker of diabetic nephropathy
    J Pediatr Endocrinol Metab17, 1663-1666. PubMed  Europe PubMed
  65. [YEAR:8-6-2004]Hengst,J.A. and Bond,J.S.
    Transport of meprin subunits through the secretory pathway: role of the transmembrane and cytoplasmic domains and oligomerization
    J Biol Chem279, 34856-34864. PubMed  Europe PubMed DOI
  66. [YEAR:1-3-2004]Kruse,M.N., Becker,C., Lottaz,D., Kohler,D., Yiallouros,I., Krell,H.W., Sterchi,E.E. and Stocker,W.
    Human meprin alpha and beta homo-oligomers: cleavage of basement membrane proteins and sensitivity to metalloprotease inhibitors
    Biochem J378, 383-389. PubMed  Europe PubMed DOI  I
    67. 2003
  67. Becker,C., Kruse,M.N., Slotty,K.A., Kohler,D., Harris,J.R., Rosmann,S., Sterchi,E.E. and Stocker,W.
    Differences in the activation mechanism between the alpha and beta subunits of human meprin
    Biol Chem384, 825-831. PubMed  Europe PubMed DOI
  68. [YEAR:24-1-2003]Bertenshaw,G.P., Norcum,M.T. and Bond,J.S.
    Structure of homo- and hetero-oligomeric meprin metalloproteases. Dimers, tetramers, and high molecular mass multimers
    J Biol Chem278, 2522-2532. PubMed  Europe PubMed DOI
  69. Villa,J.P., Bertenshaw,G.P., Bylander,J.E. and Bond,J.S.
    Meprin proteolytic complexes at the cell surface and in extracellular spaces
    Biochem Soc Symp2003, 53-63. PubMed  Europe PubMed
  70. [YEAR:24-10-2003]Villa,J.P., Bertenshaw,G.P. and Bond,J.S.
    Critical amino acids in the active site of meprin metalloproteinases for substrate and peptide bond specificity
    J Biol Chem278, 42545-42550. PubMed  Europe PubMed DOI  P
    71. 2002
  71. Bertenshaw,G.P., Villa,J.P., Hengst,J.A. and Bond,J.S.
    Probing the active sites and mechanisms of rat metalloproteases meprin A and B
    Biol Chem383, 1175-1183. PubMed  Europe PubMed DOI
  72. Doll,B.A., Villa,J.P., Ishmael,F.T. and Bond,J.S.
    Zinc ligands in an astacin family metalloprotease meprin A
    Biol Chem383, 1167-1173. PubMed  Europe PubMed DOI
  73. [YEAR:25-10-2002]Rosmann,S., Hahn,D., Lottaz,D., Kruse,M.N., Stocker,W. and Sterchi,E.E.
    Activation of human meprin-alpha in a cell culture model of colorectal cancer is triggered by the plasminogen-activating system
    J Biol Chem277, 40650-40658. PubMed  Europe PubMed DOI
  74. [YEAR:23-10-2002]Sunnerhagen,M., Pursglove,S. and Fladvad,M.
    The new MATH: homology suggests shared binding surfaces in meprin tetramers and TRAF trimers
    FEBS Lett530, 1-3. PubMed  Europe PubMed DOI
    75. 2001
  75. [YEAR:20-4-2001]Bertenshaw,G.P., Turk,B.E., Hubbard,S.J., Matters,G.L., Bylander,J.E., Crisman,J.M., Cantley,L.C. and Bond,J.S.
    Marked differences between metalloproteases meprin A and B in substrate and peptide bond specificity
    J Biol Chem276, 13248-13255. PubMed  Europe PubMed DOI
    76. 2000
  76. [YEAR:15-2-2000]Hahn,D., Illisson,R., Metspalu,A. and Sterchi,E.E.
    Human N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase (human meprin): genomic structure of the alpha and beta subunits
    Biochem J346, 83-91. PubMed  Europe PubMed DOI
  77. [YEAR:15-7-2000]Jiang,W.P. and Le,B.
    Structure and expression of the human MEP1A gene encoding the alpha subunit of metalloendopeptidase meprin A
    Arch Biochem Biophys379, 183-187. PubMed  Europe PubMed DOI
  78. [YEAR:18-8-2000]Kadowaki,T., Tsukuba,T., Bertenshaw,G.P. and Bond,J.S.
    N-linked oligosaccharides on the meprin A metalloprotease are important for secretion and enzymatic activity, but not for apical targeting
    J Biol Chem275, 25577-25584. PubMed  Europe PubMed DOI
  79. [YEAR:7-1-2000]Kohler,D., Kruse,M., Stocker,W. and Sterchi,E.E.
    Heterologously overexpressed, affinity-purified human meprin alpha is functionally active and cleaves components of the basement membrane in vitro
    FEBS Lett465, 2-7. PubMed  Europe PubMed DOI  E
    80. 1999
  80. Lottaz,D., Hahn,D., Muller,S., Muller,C. and Sterchi,E.E.
    Secretion of human meprin from intestinal epithelial cells depends on differential expression of the alpha and beta subunits
    Eur J Biochem259, 496-504. PubMed  Europe PubMed DOI
    81. 1998
  81. [YEAR:1-1-1998]Tang,J. and Bond,J.S.
    Maturation of secreted meprin alpha during biosynthesis: Role of the furin site and identification of the COOH-terminal amino acids of the mouse kidney metalloprotease subunit
    Arch Biochem Biophys349, 192-200. PubMed  Europe PubMed DOI
  82. [YEAR:25-12-1998]Tsukuba,T. and Bond,J.S.
    Role of the COOH-terminal domains of meprin A in folding, secretion, and activity of the metalloendopeptidase
    J Biol Chem273, 35260-35267. PubMed  Europe PubMed DOI
  83. Walker,P.D., Kaushal,G.P. and Shah,S.V.
    Meprin A, the major matrix degrading enzyme in renal tubules, produces a novel nidogen fragment in vitro and in vivo
    Kidney Int53, 1673-1680. PubMed  Europe PubMed DOI
    84. 1997
  84. Jiang,W. and Beatty,B.G.
    Assignment of Mep 1a to mouse chromosome band 17C1-D1 by in situ hybridization
    Cytogenet Cell Genet76, 206-207. PubMed  Europe PubMed
  85. Jiang,W. and Flannery,A.V.
    Correlation of the exon/intron organization to the secondary structures of the protease domain of mouse meprin alpha subunit
    Gene189, 65-71. PubMed  Europe PubMed DOI
  86. Johnson,G.D. and Bond,J.S.
    Activation mechanism of meprins, members of the astacin metalloendopeptidase family
    J Biol Chem272, 28126-28132. PubMed  Europe PubMed DOI
    87. 1996
  87. Bankus,J.M. and Bond,J.S.
    Expression and distribution of meprin protease subunits in mouse intestine
    Arch Biochem Biophys331, 87-94. PubMed  Europe PubMed DOI
  88. Beynon,R.J., Oliver,S. and Robertson,D.H.
    Characterization of the soluble, secreted form of urinary meprin
    Biochem J315, 461-465. PubMed  Europe PubMed
  89. Dewald,G., Schildhaus,H.U., Mucher,G. and Zerres,K.
    A HhaI polymorphism in the human MEP1A gene encoding the alpha subunit of the metalloendopeptidase meprin
    Hum Hered46, 298-300. PubMed  Europe PubMed  M
    90. 1995
  90. Bond,J.S., Rojas,K., Overhauser,J., Zoghbi,H.Y. and Jiang,W.
    The structural genes, MEP1A and MEP1B, for the alpha and beta subunits of the metalloendopeptidase meprin map to human chromosomes 6p and 18q, respectively
    Genomics25, 300-303. PubMed  Europe PubMed DOI
  91. Trachtman,H., Valderrama,E., Dietrich,J.M. and Bond,J.S.
    The role of Meprin A in the pathogenesis of acute renal failure
    Biochem Biophys Res Commun208, 498-505. PubMed  Europe PubMed DOI
  92. Wolz,R.L. and Bond,J.S.
    Meprins A and B
    Methods Enzymol248, 325-345. PubMed  Europe PubMed DOI  V
  93. Yamaguchi,T., Fukase,M., Sugimoto,T. and Chihara,K.
    Hydrolysis of a carboxy-terminal fragment of parathyroid hormone-related protein by rat kidney: evidence for a crucial role of meprin
    Horm Metab Res27, 131-136. PubMed  Europe PubMed DOI
    94. 1994
  94. [YEAR:11-3-1994]Johnson,G.D. and Hersh,L.B.
    Expression of meprin subunit precursors. Membrane anchoring through the beta subunit and mechanism of zymogen activation
    J Biol Chem269, 7682-7688. PubMed  Europe PubMed
  95. Marchand,P., Tang,J. and Bond,J.S.
    Membrane association and oligomeric organization of the alpha and beta subunits of mouse meprin A
    J Biol Chem269, 15388-15393. PubMed  Europe PubMed
  96. Wolz,R.L.
    A kinetic comparison of the homologous proteases astacin and meprin A
    Arch Biochem Biophys310, 144-151. PubMed  Europe PubMed DOI  I
    97. 1993
  97. [YEAR:5-10-1993]Gorbea,C.M., Marchand,P., Jiang,W., Copeland,N.G., Gilbert,D.J., Jenkins,N.A. and Bond,J.S.
    Cloning, expression, and chromosomal localization of the mouse meprin beta subunit
    J Biol Chem268, 21035-21043. PubMed  Europe PubMed
    98. 1992
  98. Corbeil,D., Gaudoux,F., Wainwright,S., Ingram,J., Kenny,A.J., Boileau,G. and Crine,P.
    Molecular cloning of the alpha-subunit of rat endopeptidase- 24.18 (endopeptidase-2) and co-localization with endopeptidase- 24.11 in rat kidney by in situ hybridization
    FEBS Lett309, 203-208. PubMed  Europe PubMed DOI
  99. Johnson,G.D. and Hersh,L.B.
    Cloning a rat meprin cDNA reveals the enzyme is a heterodimer
    J Biol Chem267, 13505-13512. PubMed  Europe PubMed
    100. 1991
  100. Gorbea,C.M., Flannery,A.V. and Bond,J.S.
    Homo- and heterotetrameric forms of the membrane-bound metalloendopeptidases meprin A and B
    Arch Biochem Biophys290, 549-553. PubMed  Europe PubMed DOI
  101. Kounnas,M.Z., Wolz,R.L., Gorbea,C.M. and Bond,J.S.
    Meprin-A and -B. Cell surface endopeptidases of the mouse kidney
    J Biol Chem266, 17350-17357. PubMed  Europe PubMed
    102. 1989
  102. Barnes,K., Ingram,J. and Kenny,A.J.
    Proteins of the kidney microvillar membrane. Structural and immunochemical properties of rat endopeptidase-2 and its immunohistochemical localization in tissues of rat and mouse
    Biochem J264, 335-346. PubMed  Europe PubMed
    103. 1988
  103. Butler,P.E. and Bond,J.S.
    A latent proteinase in mouse kidney membranes. Characterization and relationship to meprin
    J Biol Chem263, 13419-13426. PubMed  Europe PubMed
  104. Stephenson,S.L. and Kenny,A.J.
    The metabolism of neuropeptides. Hydrolysis of peptides by the phosphoramidon-insensitive rat kidney enzyme 'endopeptidase-2' and by rat microvillar membranes
    Biochem J255, 45-51. PubMed  Europe PubMed  I
    105. 1987
  105. Butler,P.E., McKay,M.J. and Bond,J.S.
    Characterization of meprin, a membrane-bound metalloendopeptidase from mouse kidney
    Biochem J241, 229-235. PubMed  Europe PubMed
    106. 1986
  106. Stolc,V.
    Genetics of meprin in the rat
    J Genet65, 13-17. DOI
    107. 1981
  107. Beynon,R.J., Shannon,J.D. and Bond,J.S.
    Purification and characterization of a metallo-endoproteinase from mouse kidney
    Biochem J199, 591-598. PubMed  Europe PubMed

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2025 EBI
Terms of use