| Activity |
|---|
| Catalytic type | Metallo |
| Peplist | Included in the Peplist with identifier PL00165 |
| NC-IUBMB | Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase 3.4.24.80
|
| Enzymology | BRENDA database |
| Proteolytic events | CutDB database (110 cleavages) |
| Activity status | human: active (Itoh & Seiki, 2004)
mouse: active (Kinoh et al., 1996)
|
| Physiology | Role in activation of proform of gelatinase A. Developmentally regulated. |
| Knockout | Mice deficient in membrane-type matrix metalloproteinase 1 display severe defects in skeletal development including dwarfism, osteopenia, and craniofacial abnormalities and delayed tooth eruption. Death occurs in these mice by about 3 weeks of age (Bartlett et al., 2003). There are also defects in lung development (Irie et al., 2005). Mice lacking gelatinase A as well as membrane-type matrix metalloproteinase 1 die immediately after birth (Oh et al., 2004). |
| Pharmaceutical relevance | Believed to be important in tumor cell invasion (Iida et al., 2004). |
| Pathways |
KEGG | GnRH signaling pathway |
|
KEGG | TNF signaling pathway |
|
Other databases
| WIKIPEDIA | http://en.wikipedia.org/wiki/MMP14 |
| Cleavage site specificity |
Explanations of how to interpret the
following cleavage site sequence logo and specificity matrix can be found here. |
|---|
| Cleavage pattern | -/p/-/- l/-/-/- (based on 139 cleavages) |
