Literature for peptidase M10.014: membrane-type matrix metallopeptidase-1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, I Inhibitor, L Localization, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

2025

Constanty,F., Wu,B., Wei,K.H., Lin,I.T., Dallmann,J., Guenther,S., Lautenschlaeger,T., Priya,R., Lai,S.L., Stainier,D.Y.R. and Beisaw,A.
Border-zone cardiomyocytes and macrophages regulate extracellular matrix remodeling to promote cardiomyocyte protrusion during cardiac regeneration
Nat Commun16, 3823-3823. PubMed Europe PubMed DOI
Muraoka,S., Brodie,W.D., Mattichak,M.N., Gurrea-Rubio,M., Ikari,Y., Foster,C., Amin,M.A., Khanna,N., Amin,H., Campbell,P.L., Vichaikul,S., Model,E.N., Omara,M.M., Petrovski,S., Kozicki,K., Amarista,C., Webber,A., Ali,M., Palisoc,P.J., Hervoso,J., Ruth,J.H., Tsoi,L.C., Varga,J., Gudjonsson,J.E., Khanna,D., Fox,D.A. and Tsou,P.S.
Targeting CD13/aminopeptidase N as a novel therapeutic approach for scleroderma fibrosis
Arthritis Rheumatol77, 80-91. PubMed Europe PubMed DOI
Takatsuka,R., Terashima,M., Ishimura,A., Suzuki,T. and Takino,T.
Iron regulates MT1-MMP-mediated proMMP-2 activation and cancer cell invasion
Biochem Biophys Res Commun742, 151124-151124. PubMed Europe PubMed DOI

2024

Asthana,P. and Wong,H.L.X.
Preventing obesity, insulin resistance and type 2 diabetes by targeting MT1-MMP
Biochim Biophys Acta Mol Basis Dis1870, 167081-167081. PubMed Europe PubMed DOI
Ndoj,K., Meurs,A., Papaioannou,D., Bjune,K. and Zelcer,N.
The low-density lipoprotein receptor: Emerging post-transcriptional regulatory mechanisms
Atherosclerosis401, 119082-119082. PubMed Europe PubMed DOI V
Sabeh,F., Li,X.Y., Olson,A.W., Botvinick,E., Kurup,A., Gimenez,L.E., Cho,J.S. and Weiss,S.J.
Mmp14-dependent remodeling of the pericellular-dermal collagen interface governs fibroblast survival
J Cell Biol223, PubMed Europe PubMed DOI
Wichaiyo,S., Koonyosying,P. and Morales,N.P.
Functional Roles of Furin in Cardio-Cerebrovascular Diseases
ACS Pharmacol Transl Sci7, 570-585. PubMed Europe PubMed DOI V

2023

Bakiri,L.
Open Thy Lattice Osteoclast, Resorb me!
J Cell Biol222, PubMed Europe PubMed DOI
Bonadio,A., Wenig,B.L., Hockla,A., Radisky,E.S. and Shifman,J.M.
Designed Loop Extension Followed by Combinatorial Screening Confers High Specificity to a Broad Matrix MetalloproteinaseInhibitor
J Mol Biol435, 168095-168095. PubMed Europe PubMed DOI
Choe,H., Antee,T. and Ge,X.
Substrate derived sequences act as subsite-blocking motifs in protease inhibitory antibodies
Protein Sci32, e4691-e4691. PubMed Europe PubMed DOI
Chu,T.L., Chen,P., Yu,A.X., Kong,M., Tan,Z., Tsang,K.Y., Zhou,Z. and Cheah,K.S.E.
MMP14 cleaves PTH1R in the chondrocyte-derived osteoblast lineage, curbing signaling intensity for proper bone anabolism
elife12, PubMed Europe PubMed DOI
Da Silva,J., Freitas,J.R., do Carmo,E.R. and Gomes,J.R.
MT1-MMP and TIMP-2 are first expressed in the colon glands after a single dose of azoxymethane (AOM)
Anat Rec (Hoboken) PubMed Europe PubMed DOI
Hayun,H., Coban,M., Bhagat,A.K., Ozer,E., Alfonta,L., Caulfield,T.R., Radisky,E.S. and Papo,N.
Utilizing genetic code expansion to modify N-TIMP2 specificity towards MMP-2, MMP-9, and MMP-14
Res Sq PubMed Europe PubMed DOI
Hayun,H., Coban,M., Bhagat,A.K., Ozer,E., Alfonta,L., Caulfield,T.R., Radisky,E.S. and Papo,N.
Utilizing genetic code expansion to modify N-TIMP2 specificity towards MMP-2, MMP-9, and MMP-14
Sci Rep13, 5186-5186. PubMed Europe PubMed DOI
Ikeda,K., Kaneko,R., Tsukamoto,E., Funahashi,N. and Koshikawa,N.
Proteolytic cleavage of membrane proteins by membrane type-1 MMP regulates cancer malignant progression
Cancer Sci114, 348-356. PubMed Europe PubMed DOI V
Lee,H., Youn,I., Demissie,R., Vaid,T.M., Che,C.T., Azar,D.T. and Han,K.Y.
Identification of small molecule inhibitors against MMP-14 via High-Throughput screening
Bioorg Med Chem85, 117289-117289. PubMed Europe PubMed DOI I
Samah,N., Ugusman,A., Hamid,A.A., Sulaiman,N. and Aminuddin,A.
Role of Matrix Metalloproteinase-2 in the Development of Atherosclerosis among Patients with Coronary Artery Disease
Mediators Inflamm2023, 9715114-9715114. PubMed Europe PubMed DOI V
Strouhalova,K., Tolde,O., Rosel,D. and Brabek,J.
Cytoplasmic Tail of MT1-MMP: A Hub of MT1-MMP Regulation and Function
Int J Mol Sci24, PubMed Europe PubMed DOI V
Su,H., Shu,S., Tang,W., Zheng,C., Zhao,L. and Fan,H.
ETV4 facilitates angiogenesis in hepatocellular carcinoma by upregulating MMP14 expression
Biochem Biophys Res Commun684, 149137-149137. PubMed Europe PubMed DOI K
Tanaka,N. and Sakamoto,T.
MT1-MMP as a Key Regulator of Metastasis
Cells12, PubMed Europe PubMed DOI

2022

Fogarasi,M. and Dima,S.
The Catalytic Domain Mediates Homomultimerization of MT1-MMP and the Prodomain Interferes with MT1-MMP Oligomeric Complex Assembly
Biomolecules12, PubMed Europe PubMed DOI
Hao,Q.G., Sun,F.G., Yan,C.H. and Sun,J.W.
Progress on the role and mechanism of MT1-MMP in tumor metastasis
Yi Chuan44, 745-755. PubMed Europe PubMed DOI V
Kumper,M., Zamek,J., Steinkamp,J., Pach,E., Mauch,C. and Zigrino,P.
Role of MMP3 and fibroblast-MMP14 in skin homeostasis and repair
Eur J Cell Biol101, 151276-151276. PubMed Europe PubMed DOI
Maybee,D.V., Ink,N.L. and Ali,M.A.M.
Novel Roles of MT1-MMP and MMP-2: Beyond the Extracellular Milieu
Int J Mol Sci23, PubMed Europe PubMed DOI V
Samulenas,G., Insodaite,R., Kunceviciene,E., Poceviciute,R., Masionyte,L., Zitkeviciute,U., Pilipaityte,L. and Smalinskiene,A.
The Role of Functional Polymorphisms in the Extracellular Matrix Modulation-Related Genes on Dupuytren's Contracture
Genes (Basel)13, PubMed Europe PubMed DOI
Werny,L., Grogro,A., Bickenbach,K., Bulck,C., Armbrust,F., Koudelka,T., Pathak,K., Scharfenberg,F., Sammel,M., Sheikhouny,F., Tholey,A., Linder,S. and Becker-Pauly,C.
MT1-MMP and ADAM10/17 exhibit a remarkable overlap of shedding properties
FEBS J290, 93-111. PubMed Europe PubMed DOI

2021

Alabi,A., Xia,X.D., Gu,H.M., Wang,F., Deng,S.J., Yang,N., Adijiang,A., Douglas,D.N., Kneteman,N.M., Xue,Y., Chen,L., Qin,S., Wang,G. and Zhang,D.W.
Membrane type 1 matrix metalloproteinase promotes LDL receptor shedding and accelerates the development of atherosclerosis
Nat Commun12, 1889-1889. PubMed Europe PubMed DOI K
Bassiouni,W., Ali,M.A.M. and Schulz,R.
Multifunctional intracellular matrix metalloproteinases: implications in disease
FEBS J288, 7162-7182. PubMed Europe PubMed DOI V
Butler,S.S., Date,K., Okumura,T., Lueck,C., Ghosh,B., Maitra,A. and Suh,J.
Membrane-bound MMP-14 protease-activatable adeno-associated viral vectors for gene delivery to pancreatic tumors
Gene Ther PubMed Europe PubMed DOI
Kumper,M., Hessenthaler,S., Zamek,J., Niland,S., Pach,E., Mauch,C. and Zigrino,P.
Loss of Endothelial Cell Matrix Metalloproteinase 14 Reduces Melanoma Growth and Metastasis by Increasing Tumor Vessel Stability
J Invest Dermatol PubMed Europe PubMed DOI
Pach,E., Kumper,M., Fromme,J.E., Zamek,J., Metzen,F., Koch,M., Mauch,C. and Zigrino,P.
Extracellular Matrix Remodeling by Fibroblast-MMP14 Regulates Melanoma Growth
Int J Mol Sci22, PubMed Europe PubMed DOI
Wang,X., Meng,Q., Wang,Y. and Gao,Y.
Overexpression of MMP14 predicts the poor prognosis in gastric cancer: Meta-analysis and database validation
Medicine (Baltimore)100, e26545-e26545. PubMed Europe PubMed DOI
Yamahana,H., Terashima,M., Takatsuka,R., Asada,C., Suzuki,T., Uto,Y. and Takino,T.
Erratum: TGF-beta1 facilitates MT1-MMP-mediated proMMP-9 activation and invasion in oral squamous cell carcinoma cells (BBREP_101072)
Biochem Biophys Rep27, 101093-101093. PubMed Europe PubMed DOI

2020

Attur,M., Lu,C., Zhang,X., Han,T., Alexandre,C., Valacca,C., Zheng,S., Meikle,S., Dabovic,B.B., Tassone,E., Yang,Q., Kolupaeva,V., Yakar,S., Abramson,S. and Mignatti,P.
Membrane-type 1 Matrix Metalloproteinase Modulates Tissue Homeostasis by a Non-proteolytic Mechanism
iScience23, 101789-101789. PubMed Europe PubMed DOI
Azevedo Martins,J.M., Rabelo-Santos,S.H., do Amaral Westin,M.C. and Zeferino,L.C.
Tumoral and stromal expression of MMP-2, MMP-9, MMP-14, TIMP-1, TIMP-2, and VEGF-A in cervical cancer patient survival: a competing risk analysis
BMC Cancer20, 660-660. PubMed Europe PubMed DOI
Carreca,A.P., Pravata,V.M., Markham,M., Bonelli,S., Murphy,G., Nagase,H., Troeberg,L. and Scilabra,S.D.
TIMP-3 facilitates binding of target metalloproteinases to the endocytic receptor LRP-1 and promotes scavenging of MMP-1
Sci Rep10, 12067-12067. PubMed Europe PubMed DOI
Chen,N., Zhang,G., Fu,J. and Wu,Q.
Matrix metalloproteinase-14 (MMP-14) downregulation inhibits esophageal squamous cell carcinoma cell migration, invasion, and proliferation
Thorac Cancer11, 3168-3174. PubMed Europe PubMed DOI K
Hu,Z., Gu,H., Ni,J., Hu,S., Hu,J., Wang,X., Liu,X. and Liu,X.
Matrix metalloproteinase-14 regulates collagen degradation and migration of mononuclear cells during infection with genotype VII Newcastle disease virus
J Gen Virol PubMed Europe PubMed DOI
Ingvarsen,S.Z., Gardsvoll,H., van Putten,S., Norregaard,K.S., Krigslund,O., Meilstrup,J.A., Tran,C., Jurgensen,H.J., Melander,M.C., Nielsen,C.H., Kjaer,A., Bugge,T.H., Engelholm,L.H. and Behrendt,N.
Tumor cell MT1-MMP is dispensable for osteosarcoma tumor growth, bone degradation and lung metastasis
Sci Rep10, 19138-19138. PubMed Europe PubMed DOI
Jiang,Z., Zhou,J., Qin,X., Zheng,H., Gao,B., Liu,X.G., Jin,G. and Zhou,Z.
MT1-MMP deficiency leads to defective ependymal cell maturation, impaired ciliogenesis and hydrocephalus
JCI Insight PubMed Europe PubMed DOI K
Ke,J.Y., Yang,J., Li,J., Xu,Z., Li,M.Q. and Zhu,Z.L.
Baicalein inhibits FURIN-MT1-MMP-mediated invasion of ectopic endometrial stromal cells in endometriosis possibly by reducing the secretion of TGFB1
Am J Reprod Immunole13344-e13344. PubMed Europe PubMed DOI
Llorente,P., Martins,S., Sastre,I., Aldudo,J., Recuero,M., Adjaye,J. and Bullido,M.J.
Matrix Metalloproteinase 14 Mediates APP Proteolysis and Lysosomal Alterations Induced by Oxidative Stress in Human Neuronal Cells
Oxid Med Cell Longev2020, 5917187-5917187. PubMed Europe PubMed DOI
Matsuzaki,T., Keene,D.R., Nishimoto,E. and Noda,M.
Reversion-inducing cysteine-rich protein with Kazal motifs and MT1-MMP promote the formation of robust fibrillin fibers
J Cell Physiol PubMed Europe PubMed DOI
Nam,D.H., Lee,K.B., Kruchowy,E., Pham,H. and Ge,X.
Protease Inhibition Mechanism of Camelid-like Synthetic Human Antibodies
Biochemistry59, 3802-3812. PubMed Europe PubMed DOI
Oentaryo,M.J., Tse,A.C. and Lee,C.W.
Neuronal MT1-MMP mediates ECM clearance and Lrp4 cleavage for agrin deposition and signaling in presynaptic development
J Cell Sci133, PubMed Europe PubMed DOI K
Suarez,H., Lopez-Martin,S., Toribio,V., Zamai,M., Hernandez-Riquer,M.V., Genis,L., Arroyo,A.G. and Yanez-Mo,M.
Regulation of MT1-MMP activity through its association with ERMs
Cells9, PubMed Europe PubMed DOI
Zhang,Z., Bartsch,J.W., Benzel,J., Lei,T., Nimsky,C. and Voellger,B.
Selective estrogen receptor modulators decrease invasiveness in pituitary adenoma cell lines AtT-20 and TtT/GF by affecting expression of MMP-14 and ADAM12
FEBS Open Bio10, 2489-2498. PubMed Europe PubMed DOI

2019

Cuffaro,D., Nuti,E., Gifford,V., Ito,N., Camodeca,C., Tuccinardi,T., Nencetti,S., Orlandini,E., Itoh,Y. and Rossello,A.
Design, synthesis and biological evaluation of bifunctional inhibitors of membrane type 1 matrix metalloproteinase (MT1-MMP)
Bioorg Med Chem27, 196-207. PubMed Europe PubMed DOI I
D'Amico,G., Munoz-Felix,J.M., Pedrosa,A.R. and Hodivala-Dilke,K.M.
"Splitting the matrix": intussusceptive angiogenesis meets MT1-MMP
EMBO Mol Mede11663-e11663. PubMed Europe PubMed DOI
Jiang,B., Liu,J. and Lee,M.H.
Targeting a designer TIMP-1 to the cell surface for effective MT1-MMP inhibition: a potential role for the prion protein in renal carcinoma therapy
Molecules24, PubMed Europe PubMed DOI
Knapinska,A.M. and Fields,G.B.
The expanding role of MT1-MMP in cancer progression
Pharmaceuticals (Basel)12, PubMed Europe PubMed DOI V
Lee,K.B., Dunn,Z. and Ge,X.
Reducing proteolytic liability of a MMP-14 inhibitory antibody by site-saturation mutagenesis
Protein Sci28, 643-653. PubMed Europe PubMed DOI
Li,X., Ma,Z., Wang,H., Ren,L., Zhang,D., Liang,W., Zhang,G., Zhang,J., Yu,D. and Fang,X.
Screening, identification, and characterization of an affinity peptide specific to MT1-MMP and its application in tumor imaging
Bioconjug Chem30, 1507-1517. PubMed Europe PubMed DOI L
Ma,F., Zhu,Y., Chen,Y., Liu,J. and Zeng,X.
Labeled and non-label electrochemical peptide inhibitor-based biosensing platform for determination of hemopexin domain of matrix metalloproteinase-14
Talanta194, 548-553. PubMed Europe PubMed DOI A
Ma,F., Yan,J., Sun,L. and Chen,Y.
Electrochemical impedance spectroscopy for quantization of matrix metalloproteinase-14 based on peptides inhibiting its homodimerization and heterodimerization
Talanta205, 120142-120142. PubMed Europe PubMed DOI A
Miekus,N., Luise,C., Sippl,W., Baczek,T., Schmelzer,C.E.H. and Heinz,A.
MMP-14 degrades tropoelastin and elastin
Biochimie165, 32-39. PubMed Europe PubMed DOI P
Pietraszek-Gremplewicz,K., Karamanou,K., Niang,A., Dauchez,M., Belloy,N., Maquart,F.X., Baud,S. and Brezillon,S.
Small leucine-rich proteoglycans and matrix metalloproteinase-14: key partners?
Matrix Biol75-76, 271-285. PubMed Europe PubMed DOI
Qi,Y., Wang,J., Sun,M., Ma,C., Jin,T., Liu,Y., Cao,Y. and Wang,J.
MMP-14 single-nucleotide polymorphisms are related to steroid-induced osteonecrosis of the femoral head in the population of northern China
Mol Genet Genomic Med7, e00519-e00519. PubMed Europe PubMed DOI M
Yip,C., Foidart,P., Noel,A. and Sounni,N.E.
MT4-MMP: the GPI-anchored membrane-type matrix metalloprotease with multiple functions in diseases
Int J Mol Sci20, PubMed Europe PubMed DOI

2018

Akhtar,N.
Hijacking a morphogenesis proteinase for cancer cell invasion
Dev Cell47, 135-137. PubMed Europe PubMed DOI
Amara,N., Tholen,M. and Bogyo,M.
Chemical tools for selective activity profiling of endogenously expressed MMP-14 in multicellular models
ACS Chem Biol13, 2645-2654. PubMed Europe PubMed DOI
Chen,K.E., Chen,C., Lopez,T., Radecki,K.C., Bustamante,K., Lorenson,M.Y., Ge,X. and Walker,A.M.
Use of a novel camelid-inspired human antibody demonstrates the importance of MMP-14 to cancer stem cell function in the metastatic process
Oncotarget9, 29431-29444. PubMed Europe PubMed DOI
Kikuchi,K., Kozuka-Hata,H., Oyama,M., Seiki,M. and Koshikawa,N.
Identification of proteolytic cleavage sites of EphA2 by membrane type 1 matrix metalloproteinase on the surface of cancer cells
Methods Mol Biol1731, 29-37. PubMed Europe PubMed DOI P
Li,N., Zhang,W., Lin,L., He,Z., Khan,M. and Lin,J.M.
Live imaging of cell membrane-localized MT1-MMP activity on a microfluidic chip
Chem Commun (Camb)54, 11435-11438. PubMed Europe PubMed DOI L
Liu,M., Qi,Y., Zhao,L., Chen,D., Zhou,Y., Zhou,H., Lv,Y., Zhang,L., Jin,S., Li,S., Zou,H., Jia,W., Wang,C., Jiang,J., Liang,W., Pang,L. and Li,F.
Matrix metalloproteinase-14 induces epithelial-to-mesenchymal transition in synovial sarcoma
Hum Pathol80, 201-209. PubMed Europe PubMed DOI
Lopez,T., Chuan,C., Ramirez,A., Chen,K.E., Lorenson,M.Y., Benitez,C., Mustafa,Z., Pham,H., Sanchez,R., Walker,A.M. and Ge,X.
Epitope-specific affinity maturation improved stability of potent protease inhibitory antibodies
Biotechnol Bioeng115, 2673-2682. PubMed Europe PubMed DOI
Nam,D.H. and Ge,X.
Generation of highly selective MMP antibody inhibitors
Methods Mol Biol1731, 307-324. PubMed Europe PubMed DOI
Sakr,M., Li,X.Y., Sabeh,F., Feinberg,T.Y., Tesmer,J.J.G., Tang,Y. and Weiss,S.J.
Tracking the Cartoon mouse phenotype: hemopexin domain-dependent regulation of MT1-MMP pericellular collagenolytic activity
J Biol Chem293, 8113-8127. PubMed Europe PubMed DOI M
Shirian,J., Arkadash,V., Cohen,I., Sapir,T., Radisky,E.S., Papo,N. and Shifman,J.M.
Converting a broad matrix metalloproteinase family inhibitor into a specific inhibitor of MMP-9 and MMP-14
FEBS Lett592, 1122-1134. PubMed Europe PubMed DOI
Takahashi,Y., Hamasaki,M., Aoki,M., Koga,K., Koshikawa,N., Miyamoto,S. and Nabeshima,K.
Activated EphA2 processing by MT1-MMP is involved in malignant transformation of ovarian tumours in vivo
Anticancer Res38, 4257-4266. PubMed Europe PubMed DOI

2017

Almalki,S.G., Llamas Valle,Y. and Agrawal,D.K.
MMP-2 and MMP-14 silencing inhibits VEGFR2 cleavage and induces the differentiation of porcine adipose-derived mesenchymal stem cells to endothelial cells
Stem Cells Transl Med6, 1385-1398. PubMed Europe PubMed DOI K
Arkadash,V., Yosef,G., Shirian,J., Cohen,I., Horev,Y., Grossman,M., Sagi,I., Radisky,E.S., Shifman,J.M. and Papo,N.
Development of high affinity and high specificity inhibitors of matrix metalloproteinase 14 through computational design and directed evolution
J Biol Chem292, 3481-3495. PubMed Europe PubMed DOI
Butler,G.S., Connor,A.R., Sounni,N.E., Eckhard,U., Morrison,C.J., Noel,A. and Overall,C.M.
Degradomic and yeast 2-hybrid inactive catalytic domain substrate trapping identifies new membrane-type 1 matrix metalloproteinase (MMP14) substrates: CCN3 (Nov) and CCN5 (WISP2)
Matrix Biol59, 23-38. PubMed Europe PubMed DOI P
Cepeda,M.A., Evered,C.L., Pelling,J.J.H. and Damjanovski,S.
Inhibition of MT1-MMP proteolytic function and ERK1/2 signalling influences cell migration and invasion through changes in MMP-2 and MMP-9 levels
J Cell Commun Signal11, 167-179. PubMed Europe PubMed DOI
Decaneto,E., Vasilevskaya,T., Kutin,Y., Ogata,H., Grossman,M., Sagi,I., Havenith,M., Lubitz,W., Thiel,W. and Cox,N.
Solvent water interactions within the active site of the membrane type I matrix metalloproteinase
Phys Chem Chem Phys19, 30316-30331. PubMed Europe PubMed DOI
Decaneto,E., Lubitz,W. and Ogata,H.
Structural studies of matrix metalloproteinase by X-ray diffraction
Methods Mol Biol1579, 49-60. PubMed Europe PubMed DOI E S
Hong,S., Remacle,A.G., Shiryaev,S.A., Choi,W., Hullugundi,S.K., Dolkas,J., Angert,M., Nishihara,T., Yaksh,T.L., Strongin,A.Y. and Shubayev,V.I.
Reciprocal relationship between membrane type 1 matrix metalloproteinase and the algesic peptides of myelin basic protein contributes to chronic neuropathic pain
Brain Behav Immun60, 282-292. PubMed Europe PubMed DOI
Jiang,B., Zhang,Y., Liu,J., Tsigkou,A., Rapti,M. and Lee,M.H.
Ensnaring membrane type 1-matrix metalloproteinase (MT1-MMP) with tissue inhibitor of metalloproteinase (TIMP)-2 using the haemopexin domain of the protease as a carrier: a targeted approach in cancer inhibition
Oncotarget8, 22685-22699. PubMed Europe PubMed DOI
Ling,B., Watt,K., Banerjee,S., Newsted,D., Truesdell,P., Adams,J., Sidhu,S.S. and Craig,A.W.
A novel immunotherapy targeting MMP-14 limits hypoxia, immune suppression and metastasis in triple-negative breast cancer models
Oncotarget8, 58372-58385. DOI
Lopez,T., Nam,D.H., Kaihara,E., Mustafa,Z. and Ge,X.
Identification of highly selective MMP-14 inhibitory Fabs by deep sequencing
Biotechnol Bioeng114, 1140-1150. PubMed Europe PubMed DOI
Majkowska,I., Shitomi,Y., Ito,N., Gray,N.S. and Itoh,Y.
Discoidin domain receptor 2 mediates collagen-induced activation of membrane-type 1 matrix metalloproteinase in human fibroblasts
J Biol Chem292, 6633-6643. PubMed Europe PubMed DOI
Nam,D.H., Fang,K., Rodriguez,C., Lopez,T. and Ge,X.
Generation of inhibitory monoclonal antibodies targeting matrix metalloproteinase-14 by motif grafting and CDR optimization
Protein Eng Des Sel30, 113-118. PubMed Europe PubMed DOI
Stawowczyk,M., Wellenstein,M.D., Lee,S.B., Yomtoubian,S., Durrans,A., Choi,H., Narula,N., Altorki,N.K., Gao,D. and Mittal,V.
Matrix metalloproteinase 14 promotes lung cancer by cleavage of heparin-binding EGF-like growth factor
Neoplasia19, 55-64. PubMed Europe PubMed DOI
Yamamoto,K., Santamaria,S., Botkjaer,K.A., Dudhia,J., Troeberg,L., Itoh,Y., Murphy,G. and Nagase,H.
Inhibition of shedding of low-density lipoprotein receptor-related protein 1 reverses cartilage matrix degradation in osteoarthritis
Arthritis Rheumatol69, 1246-1256. PubMed Europe PubMed DOI

2016

Botkjaer,K.A., Kwok,H.F., Terp,M.G., Karatt-Vellatt,A., Santamaria,S., McCafferty,J., Andreasen,P.A., Itoh,Y., Ditzel,H.J. and Murphy,G.
Development of a specific affinity-matured exosite inhibitor to MT1-MMP that efficiently inhibits tumor cell invasion in vitro and metastasis in vivo
Oncotarget7, 16773-16792. PubMed Europe PubMed DOI
Castro-Castro,A., Marchesin,V., Monteiro,P., Lodillinsky,C., Rosse,C. and Chavrier,P.
Cellular and molecular mechanisms of MT1-MMP-dependent cancer cell invasion
Annu Rev Cell Dev Biol32, 555-576. PubMed Europe PubMed DOI
de Lucas,A.G., Schuhmacher,A.J., Oteo,M., Romero,E., Camara,J.A., de Martino,A., Arroyo,A.G., Morcillo,M.A., Squatrito,M., Martinez-Torrecuadrada,J.L. and Mulero,F.
Targeting MT1-MMP as an ImmunoPET-based strategy for imaging gliomas
PLoS ONE11, e0158634-e0158634. PubMed Europe PubMed DOI L
El Azzouzi,K., Wiesner,C. and Linder,S.
Metalloproteinase MT1-MMP islets act as memory devices for podosome reemergence
J Cell Biol213, 109-125. PubMed Europe PubMed DOI
Fan,L., Liu,L., Zhu,C., Zhu,Q., Lu,S. and Liu,P.
MT1-MMP inhibits the activity of Bst-2 via their cytoplasmic domains dependent interaction
Int J Mol Sci17, PubMed Europe PubMed DOI
Gucciardo,E., Mobashir,M. and Lehti,K.
Proactive for invasion: reuse of matrix metalloproteinase for structural memory
J Cell Biol213, 11-13. PubMed Europe PubMed DOI
Kaneko,K., Williams,R.O., Dransfield,D.T., Nixon,A.E., Sandison,A. and Itoh,Y.
Selective inhibition of membrane type 1 matrix metalloproteinase abrogates progression of experimental inflammatory arthritis: synergy with tumor necrosis factor blockade
Arthritis Rheumatol68, 521-531. PubMed Europe PubMed DOI
Ku,M., Hong,Y., Heo,D., Lee,E., Hwang,S., Suh,J.S. and Yang,J.
In vivo sensing of proteolytic activity with an NSET-based NIR fluorogenic nanosensor
Biosens Bioelectron77, 471-477. PubMed Europe PubMed DOI L
Mendes,D.E., Wong-On-Wing,A. and Berkman,C.E.
Phosphoramidate-based peptidomimetic inhibitors of membrane type-1 matrix metalloproteinase
J Enzyme Inhib Med Chem31, 167-171. PubMed Europe PubMed DOI I
Nam,D.H. and Ge,X.
Direct production of functional matrix metalloproteinase-14 without refolding or activation and its application for in vitro inhibition assays
Biotechnol Bioeng113, 717-723. PubMed Europe PubMed DOI E
Nam,D.H., Rodriguez,C., Remacle,A.G., Strongin,A.Y. and Ge,X.
Active-site MMP-selective antibody inhibitors discovered from convex paratope synthetic libraries
Proc Natl Acad Sci U S A113, 14970-14975. PubMed Europe PubMed DOI
Nguyen,M.D. and Kang,K.A.
MMP-14 triggered fluorescence contrast agent
Adv Exp Med Biol923, 413-419. PubMed Europe PubMed DOI A
Tatsukawa,R., Koga,K., Aoki,M., Koshikawa,N., Imafuku,S., Nakayama,J. and Nabeshima,K.
Immunohistochemical demonstration of EphA2 processing by MT1-MMP in invasive cutaneous squamous cell carcinoma
Virchows Arch469, 25-34. PubMed Europe PubMed DOI
Thakur,V. and Bedogni,B.
The membrane tethered matrix metalloproteinase MT1-MMP at the forefront of melanoma cell invasion and metastasis
Pharmacol Res111, 17-22. PubMed Europe PubMed DOI
Wong,H.L., Jin,G., Cao,R., Zhang,S., Cao,Y. and Zhou,Z.
MT1-MMP sheds LYVE-1 on lymphatic endothelial cells and suppresses VEGF-C production to inhibit lymphangiogenesis
Nat Commun7, 10824-10824. PubMed Europe PubMed DOI

2015

Bhowmick,M., Stawikowska,R., Tokmina-Roszyk,D. and Fields,G.B.
Matrix metalloproteinase inhibition by heterotrimeric triple-helical peptide transition state analogues
Chembiochem16, 1084-1092. PubMed Europe PubMed DOI I
Chung,E.Y., Ochs,C.J., Wang,Y., Lei,L., Qin,Q., Smith,A.M., Strongin,A.Y., Kamm,R., Qi,Y.X., Lu,S. and Wang,Y.
Activatable and cell-penetrable multiplex FRET nanosensor for profiling MT1-MMP activity in single cancer cells
Nano Lett15, 5025-5032. PubMed Europe PubMed DOI L
Decaneto,E., Suladze,S., Rosin,C., Havenith,M., Lubitz,W. and Winter,R.
Pressure and temperature effects on the activity and structure of the catalytic domain of human MT1-MMP
Biophys J109, 2371-2381. PubMed Europe PubMed DOI
Gutierrez-Fernandez,A., Soria-Valles,C., Osorio,F.G., Gutierrez-Abril,J., Garabaya,C., Aguirre,A., Fueyo,A., Fernandez-Garcia,M.S., Puente,X.S. and Lopez-Otin,C.
Loss of MT1-MMP causes cell senescence and nuclear defects which can be reversed by retinoic acid
EMBO J34, 1875-1888. PubMed Europe PubMed DOI
Nuti,E., Cantelmo,A.R., Gallo,C., Bruno,A., Bassani,B., Camodeca,C., Tuccinardi,T., Vera,L., Orlandini,E., Nencetti,S., Stura,E.A., Martinelli,A., Dive,V., Albini,A. and Rossello,A.
N-O-Isopropyl sulfonamido-based hydroxamates as matrix metalloproteinase inhibitors: hit selection and in vivo antiangiogenic activity
J Med Chem58, 7224-7240. PubMed Europe PubMed DOI I
Overland,A.C. and Insel,P.A.
Heterotrimeric G proteins directly regulate MMP14/membrane type-1 matrix metalloprotease: a novel mechanism for GPCR-EGFR transactivation
J Biol Chem290, 9941-9947. PubMed Europe PubMed DOI
Shaverdashvili,K., Zhang,K., Osman,I., Honda,K., Jobava,R. and Bedogni,B.
MT1-MMP dependent repression of the tumor suppressor SPRY4 contributes to MT1-MMP driven melanoma cell motility
Oncotarget6, 33512-33522. PubMed Europe PubMed DOI
Snyman,C. and Niesler,C.U.
MMP-14 in skeletal muscle repair
J Muscle Res Cell Motil36, 215-225. PubMed Europe PubMed DOI
Tassone,E., Valacca,C. and Mignatti,P.
Membrane-type 1 matrix metalloproteinase downregulates fibroblast growth factor-2 binding to the cell surface and intracellular signaling
J Cell Physiol230, 366-377. PubMed Europe PubMed DOI
Taylor,S.H., Yeung,C.Y., Kalson,N.S., Lu,Y., Zigrino,P., Starborg,T., Warwood,S., Holmes,D.F., Canty-Laird,E.G., Mauch,C. and Kadler,K.E.
Matrix metalloproteinase 14 is required for fibrous tissue expansion
elife4, e09345-e09345. PubMed Europe PubMed DOI
Terawaki,S., Kitano,K., Aoyama,M., Mori,T. and Hakoshima,T.
MT1-MMP recognition by ERM proteins and its implication in CD44 shedding
Genes Cells20, 847-859. PubMed Europe PubMed DOI S
Udi,Y., Grossman,M., Solomonov,I., Dym,O., Rozenberg,H., Moreno,V., Cuniasse,P., Dive,V., Arroyo,A.G. and Sagi,I.
Inhibition mechanism of membrane metalloprotease by an exosite-swiveling conformational antibody
Structure23, 104-115. PubMed Europe PubMed DOI
Ulasov,I., Borovjagin,A.V., Kaverina,N., Schroeder,B., Shah,N., Lin,B., Baryshnikov,A. and Cobbs,C.
MT1-MMP silencing by an shRNA-armed glioma-targeted conditionally replicative adenovirus (CRAd) improves its anti-glioma efficacy in vitro and in vivo
Cancer Lett365, 240-250. PubMed Europe PubMed DOI K
Wang,Y., Lu,H., Yu,D., Zhang,J., Liang,W., Zhang,Z. and Fang,X.
Potent selective inhibition of MMP-14 by chloroauric acid and its inhibitory effect on cancer cell invasion
RSC Adv5, 17700-17708. DOI I
Zeng,L., Tan,B., Yang,Y., Qiu,J., Xiong,L. and Mao,C.
[Virtual screening and molecular simulations of antisense peptides targeting MT1-MMP]
Sheng Wu Gong Cheng Xue Bao31, 269-280. PubMed Europe PubMed DOI I
Zhao,Y., Marcink,T.C., Sanganna Gari,R.R., Marsh,B.P., King,G.M., Stawikowska,R., Fields,G.B. and Van Doren,S.R.
Transient collagen triple helix binding to a key metalloproteinase in invasion and development
Structure23, 257-269. PubMed Europe PubMed DOI

2014

Buache,E., Thai,R., Wendling,C., Alpy,F., Page,A., Chenard,M.P., Dive,V., Ruff,M., Dejaegere,A., Tomasetto,C. and Rio,M.C.
Functional relationship between matrix metalloproteinase-11 and matrix metalloproteinase-14
Cancer Med3, 1197-1210. PubMed Europe PubMed DOI
Gaublomme,D., Buyens,T., De Groef,L., Stakenborg,M., Janssens,E., Ingvarsen,S., Porse,A., Behrendt,N. and Moons,L.
Matrix metalloproteinase 2 and membrane type 1 matrix metalloproteinase co-regulate axonal outgrowth of mouse retinal ganglion cells
J Neurochem129, 966-979. PubMed Europe PubMed DOI
Hong,Y., Ku,M., Heo,D., Hwang,S., Lee,E., Park,J., Choi,J., Jung Lee,H., Seo,M., Jig Lee,E., In Yook,J., Haam,S., Huh,Y.M., Sung Yoon,D., Suh,J.S. and Yang,J.
Molecular recognition of proteolytic activity in metastatic cancer cells using fluorogenic gold nanoprobes
Biosens Bioelectron57, 171-178. PubMed Europe PubMed DOI L
Ma,J., Tang,X., Wong,P., Jacobs,B., Borden,E.C. and Bedogni,B.
Noncanonical activation of Notch1 protein by membrane type 1 matrix metalloproteinase (MT1-MMP) controls melanoma cell proliferation
J Biol Chem289, 8442-8449. PubMed Europe PubMed DOI
Ogata,H., Decaneto,E., Grossman,M., Havenith,M., Sagi,I., Lubitz,W. and Knipp,M.
Crystallization and preliminary X-ray crystallographic analysis of the catalytic domain of membrane type 1 matrix metalloproteinase
Acta Crystallogr F Struct Biol Commun70, 232-235. PubMed Europe PubMed DOI
Ouyang,M., Lu,S. and Wang,Y.
Genetically encoded fluorescent biosensors for live-cell imaging of MT1-MMP protease activity
Methods Mol Biol1071, 163-174. PubMed Europe PubMed DOI L
Pietraszek,K., Chatron-Colliet,A., Brezillon,S., Perreau,C., Jakubiak-Augustyn,A., Krotkiewski,H., Maquart,F.X. and Wegrowski,Y.
Lumican: a new inhibitor of matrix metalloproteinase-14 activity
FEBS Lett588, 4319-4324. PubMed Europe PubMed DOI
Tobar,N., Avalos,M.C., Mendez,N., Smith,P.C., Bernabeu,C., Quintanilla,M. and Martinez,J.
Soluble MMP-14 produced by bone marrow-derived stromal cells sheds epithelial endoglin modulating the migratory properties of human breast cancer cells
Carcinogenesis35, 1770-1779. PubMed Europe PubMed DOI
Wali,N., Hosokawa,K., Malik,S., Saito,H., Miyaguchi,K., Imajoh-Ohmi,S., Miki,Y. and Nakanishi,A.
Centrosomal BRCA2 is a target protein of membrane type-1 matrix metalloproteinase (MT1-MMP)
Biochem Biophys Res Commun443, 1148-1154. PubMed Europe PubMed DOI P

2013

Alcantara,M.B. and Dass,C.R.
Regulation of MT1-MMP and MMP-2 by the serpin PEDF: a promising new target for metastatic cancer
Cell Physiol Biochem31, 487-494. PubMed Europe PubMed DOI
Hiden,U., Ghaffari-Tabrizi,N., Gauster,M., Tam-Amersdorfer,C., Cetin,I., Dieber-Rotheneder,M., Lang,U. and Desoye,G.
Membrane-type matrix metalloproteinase 1 regulates trophoblast functions and is reduced in fetal growth restriction
Am J Pathol182, 1563-1571. PubMed Europe PubMed DOI
Ingvarsen,S., Porse,A., Erpicum,C., Maertens,L., Jurgensen,H.J., Madsen,D.H., Melander,M.C., Gardsvoll,H., Hoyer-Hansen,G., Noel,A., Holmbeck,K., Engelholm,L.H. and Behrendt,N.
Targeting a single function of the multifunctional matrix metalloprotease MT1-MMP: impact on lymphangiogenesis
J Biol Chem288, 10195-10204. PubMed Europe PubMed DOI
Janssens,E., Gaublomme,D., De Groef,L., Darras,V.M., Arckens,L., Delorme,N., Claes,F., Van Hove,I. and Moons,L.
Matrix metalloproteinase 14 in the zebrafish: an eye on retinal and retinotectal development
PLoS ONE8, e52915-e52915. PubMed Europe PubMed DOI
Kaimal,R., Aljumaily,R., Tressel,S.L., Pradhan,R.V., Covic,L., Kuliopulos,A., Zarwan,C., Kim,Y.B., Sharifi,S. and Agarwal,A.
Selective blockade of matrix metalloprotease-14 with a monoclonal antibody abrogates invasion, angiogenesis, and tumor growth in ovarian cancer
Cancer Res73, 2457-2467. PubMed Europe PubMed DOI
Keely,P.J.
Proteolytic remodeling of the ECM and the geometric control of stem cell fate
Dev Cell25, 325-326. PubMed Europe PubMed DOI
Lee,H., Chang,K.W., Yang,H.Y., Lin,P.W., Chen,S.U. and Huang,Y.L.
MT1-MMP regulates MMP-2 expression and angiogenesis-related functions in human umbilical vein endothelial cells
Biochem Biophys Res Commun437, 232-238. PubMed Europe PubMed DOI
Manon-Jensen,T., Multhaupt,H.A. and Couchman,J.R.
Mapping of matrix metalloproteinase cleavage sites on syndecan-1 and syndecan-4 ectodomains
FEBS J280, 2320-2331. PubMed Europe PubMed DOI P
Marques,S.M., Abate,C.C., Chaves,S., Marques,F., Santos,I., Nuti,E., Rossello,A. and Santos,M.A.
New bifunctional metalloproteinase inhibitors: an integrated approach towards biological improvements and cancer therapy
J Inorg Biochem127, 188-202. PubMed Europe PubMed DOI I
Remacle,A.G., Shiryaev,S.A., Golubkov,V.S., Freskos,J.N., Brown,M.A., Karwa,A.S., Naik,A.D., Howard,C.P., Sympson,C.J. and Strongin,A.Y.
Non-destructive and selective imaging of the functionally active, pro-invasive membrane type-1 matrix metalloproteinase (MT1-MMP) enzyme in cancer cells
J Biol Chem288, 20568-20580. PubMed Europe PubMed DOI L
Schroder,H.M., Hoffmann,S.C., Hecker,M., Korff,T. and Ludwig,T.
The tetraspanin network modulates MT1-MMP cell surface trafficking
Int J Biochem Cell Biol45, 1133-1144. PubMed Europe PubMed DOI
Stegemann,C., Didangelos,A., Barallobre-Barreiro,J., Langley,S.R., Mandal,K., Jahangiri,M. and Mayr,M.
Proteomic identification of matrix metalloproteinase substrates in the human vasculature
Circ Cardiovasc Genet6, 106-117. PubMed Europe PubMed DOI P
Sugiyama,N., Gucciardo,E., Tatti,O., Varjosalo,M., Hyytiainen,M., Gstaiger,M. and Lehti,K.
EphA2 cleavage by MT1-MMP triggers single cancer cell invasion via homotypic cell repulsion
J Cell Biol201, 467-484. PubMed Europe PubMed DOI
Takahashi,T., Fujimori,C., Hagiwara,A. and Ogiwara,K.
Recent advances in the understanding of teleost medaka ovulation: the roles of proteases and prostaglandins
Zoolog Sci30, 239-247. PubMed Europe PubMed DOI
Woskowicz,A.M., Weaver,S.A., Shitomi,Y., Ito,N. and Itoh,Y.
MT-LOOP-dependent localization of membrane type I matrix metalloproteinase (MT1-MMP) to the cell adhesion complexes promotes cancer cell invasion
J Biol Chem288, 35126-35137. PubMed Europe PubMed DOI

2012

Basu,B., Correa de Sampaio,P., Mohammed,H., Fogarasi,M., Corrie,P., Watkins,N.A., Smethurst,P.A., English,W.R., Ouwehand,W.H. and Murphy,G.
Inhibition of MT1-MMP activity using functional antibody fragments selected against its hemopexin domain
Int J Biochem Cell Biol44, 393-403. PubMed Europe PubMed DOI
Chan,K.M., Wong,H.L., Jin,G., Liu,B., Cao,R., Cao,Y., Lehti,K., Tryggvason,K. and Zhou,Z.
MT1-MMP inactivates ADAM9 to regulate FGFR2 signaling and calvarial osteogenesis
Dev Cell22, 1176-1190. PubMed Europe PubMed DOI
Cork,S.M., Kaur,B., Devi,N.S., Cooper,L., Saltz,J.H., Sandberg,E.M., Kaluz,S. and Van Meir,E.G.
A proprotein convertase/MMP-14 proteolytic cascade releases a novel 40kDa vasculostatin from tumor suppressor BAI1
Oncogene31, 5144-5152. PubMed Europe PubMed DOI
Domoto,T., Takino,T., Guo,L. and Sato,H.
Cleavage of hepatocyte growth factor activator inhibitor-1 by membrane-type MMP-1 activates matriptase
Cancer Sci103, 448-454. PubMed Europe PubMed DOI
Eisenach,P.A., de Sampaio,P.C., Murphy,G. and Roghi,C.
Membrane type 1 matrix metalloproteinase (MT1-MMP) ubiquitination at Lys581 increases cellular invasion through type I collagen
J Biol Chem287, 11533-11545. PubMed Europe PubMed DOI
Evans,B.R., Mosig,R.A., Lobl,M., Martignetti,C.R., Camacho,C., Grum-Tokars,V., Glucksman,M.J. and Martignetti,J.A.
Mutation of membrane type-1 metalloproteinase, MT1-MMP, causes the multicentric osteolysis and arthritis disease Winchester syndrome
Am J Hum Genet91, 572-576. PubMed Europe PubMed DOI M
Guo,L., Takino,T., Endo,Y., Domoto,T. and Sato,H.
Shedding of kidney injury molecule-1 by membrane-type 1 matrix metalloproteinase
J Biochem152, 425-432. PubMed Europe PubMed DOI
Itoh,Y. and Seiki,M.
Membrane-type matrix metalloproteinase 1
[ISSN:978-0-12-407744-7]3, 804-814. DOI
Koziol,A., Gonzalo,P., Mota,A., Pollan,A., Lorenzo,C., Colome,N., Montaner,D., Dopazo,J., Arribas,J., Canals,F. and Arroyo,A.G.
The protease MT1-MMP drives a combinatorial proteolytic program in activated endothelial cells
FASEB J26, 4481-4494. PubMed Europe PubMed DOI
Kulkarni,R.N., Bakker,A.D., Gruber,E.V., Chae,T.D., Veldkamp,J.B., Klein-Nulend,J. and Everts,V.
MT1-MMP modulates the mechanosensitivity of osteocytes
Biochem Biophys Res Commun417, 824-829. PubMed Europe PubMed DOI
Lee,G., Eom,K., Park,J., Yang,J., Haam,S., Huh,Y.M., Ryu,J.K., Kim,N.H., Yook,J.I., Lee,S.W., Yoon,D.S. and Kwon,T.
Real-time quantitative monitoring of specific peptide cleavage by a proteinase for cancer diagnosis
Angew Chem Int Ed Engl51, 5837-5841. PubMed Europe PubMed DOI A
Malinowski,M., Pietraszek,K., Perreau,C., Boguslawski,M., Decot,V., Stoltz,J.F., Vallar,L., Niewiarowska,J., Cierniewski,C., Maquart,F.X., Wegrowski,Y. and Brezillon,S.
Effect of lumican on the migration of human mesenchymal stem cells and endothelial progenitor cells: involvement of matrix metalloproteinase-14
PLoS ONE7, e50709-e50709. PubMed Europe PubMed DOI
Patel,T.R., Butler,G., McFarlane,A., Xie,I., Overall,C.M. and Stetefeld,J.
Site specific cleavage mediated by MMPs regulates function of agrin
PLoS ONE7, e43669-e43669. PubMed Europe PubMed DOI P
Remacle,A.G., Golubkov,V.S., Shiryaev,S.A., Dahl,R., Stebbins,J.L., Chernov,A.V., Cheltsov,A.V., Pellecchia,M. and Strongin,A.Y.
Novel MT1-MMP small-molecule inhibitors based on insights into hemopexin domain function in tumor growth
Cancer Res72, 2339-2349. PubMed Europe PubMed DOI I
Weng,C.J., Chen,M.K., Lin,C.W., Chung,T.T. and Yang,S.F.
Single nucleotide polymorphisms and haplotypes of MMP-14 are associated with the risk and pathological development of oral cancer
Ann Surg Oncol19 Suppl 3, S319-S327. PubMed Europe PubMed DOI M
Zigrino,P., Ayachi,O., Schild,A., Kaltenberg,J., Zamek,J., Nischt,R., Koch,M. and Mauch,C.
Loss of epidermal MMP-14 expression interferes with angiogenesis but not with re-epithelialization
Eur J Cell Biol91, 748-756. PubMed Europe PubMed DOI K

2011

Ando,K., Ishibashi,T., Ohkawara,H., Inoue,N., Sugimoto,K., Uekita,H., Hu,C., Okamoto,Y., Takuwa,Y. and Takeishi,Y.
Crucial role of membrane type 1 matrix metalloproteinase (MT1- MMP) in RhoA/Rac1-dependent signaling pathways in thrombin- stimulated endothelial cells
J Atheroscler Thromb18, 762-773. PubMed Europe PubMed DOI
Choi,S.S., Ji,A.R., Yu,S.W., Cho,B.H., Park,J.D., Park,J.H., Lee,H.S., Ryu,S.E., Kim,D.H., Kang,J.H. and Lee,S.T.
Inhibition of invasion and capillary-like tube formation by retrohydroxamate-based MMP inhibitors
Bull Korean Chem Soc32, 2032-2038. DOI I
Frittoli,E., Palamidessi,A., Disanza,A. and Scita,G.
Secretory and endo/exocytic trafficking in invadopodia formation: the MT1-MMP paradigm
Eur J Cell Biol90, 108-114. PubMed Europe PubMed DOI
Galiacy,S.D., Fournie,P., Massoudi,D., Ancele,E., Quintyn,J.C., Erraud,A., Raymond-Letron,I., Rolling,F. and Malecaze,F.
Matrix metalloproteinase 14 overexpression reduces corneal scarring
Gene Ther18, 462-468. PubMed Europe PubMed DOI U
Golubkov,V.S., Chernov,A.V. and Strongin,A.Y.
Intradomain cleavage of inhibitory prodomain is essential to protumorigenic function of membrane type-1 matrix metalloproteinase (MT1-MMP) in vivo
J Biol Chem286, 34215-34223. PubMed Europe PubMed DOI
Grant Rowe,R., Keena,D., Sabeh,F., Willis,A.L. and Weiss,S.J.
Pulmonary fibroblasts mobilize the membrane-tethered matrix metalloprotease, MT1-MMP, to destructively remodel and invade interstitial type I collagen barriers
Am J Physiol Lung Cell Mol Physiol301, L683-L692. PubMed Europe PubMed DOI
Grossman,M., Born,B., Heyden,M., Tworowski,D., Fields,G.B., Sagi,I. and Havenith,M.
Correlated structural kinetics and retarded solvent dynamics at the metalloprotease active site
Nat Struct Mol Biol18, 1102-1108. PubMed Europe PubMed DOI
Hara,T., Mimura,K., Seiki,M. and Sakamoto,T.
Genetic dissection of proteolytic and non-proteolytic contributions of MT1-MMP to macrophage invasion
Biochem Biophys Res Commun413, 277-281. PubMed Europe PubMed DOI
Itoh,Y., Palmisano,R., Anilkumar,N., Nagase,H., Miyawaki,A. and Seiki,M.
Dimerization of MT1-MMP during cellular invasion detected by fluorescence resonance energy transfer
Biochem J440, 319-326. PubMed Europe PubMed DOI
Jabaiah,A. and Daugherty,P.S.
Directed evolution of protease beacons that enable sensitive detection of endogenous MT1-MMP activity in tumor cell lines
Chem Biol18, 392-401. PubMed Europe PubMed DOI P
Jin,G., Zhang,F., Chan,K.M., Xavier Wong,H.L., Liu,B., Cheah,K.S., Liu,X., Mauch,C., Liu,D. and Zhou,Z.
MT1-MMP cleaves Dll1 to negatively regulate Notch signalling to maintain normal B-cell development
EMBO J30, 2281-2293. PubMed Europe PubMed DOI I
Park,J.H., Park,S.M., Park,K.H., Cho,K.H. and Lee,S.T.
Analysis of apolipoprotein A-I as a substrate for matrix metalloproteinase-14
Biochem Biophys Res Commun409, 58-63. PubMed Europe PubMed DOI P
Robichaud,T.K., Steffensen,B. and Fields,G.B.
Exosite interactions impact matrix metalloproteinase collagen specificities
J Biol Chem286, 37535-37542. PubMed Europe PubMed DOI P
Saygili,E., Schauerte,P., Pekassa,M., Saygili,E., Rackauskas,G., Schwinger,R.H.G., Weis,J., Weber,C., Marx,N. and Rana,O.R.
Sympathetic neurons express and secrete MMP-2 and MT1-MMP to control nerve sprouting via pro-NGF conversion
Cell Mol Neurobiol31, 17-25. PubMed Europe PubMed DOI
Shi,F. and Sottile,J.
MT1-MMP regulates the turnover and endocytosis of extracellular matrix fibronectin
J Cell Sci124, 4039-4050. PubMed Europe PubMed DOI
Sina,A., Lord-Dufour,S., Roy,R. and Annabi,B.
Pharmacological targeting of MT1-MMP by actinonin in brain tumours
Bio Trib Mag38, 39-45. DOI I
Tochowicz,A., Goettig,P., Evans,R., Visse,R., Shitomi,Y., Palmisano,R., Ito,N., Richter,K., Maskos,K., Franke,D., Svergun,D., Nagase,H., Bode,W. and Itoh,Y.
The dimer interface of the membrane type 1 matrix metalloproteinase hemopexin domain: crystal structure and biological functions
J Biol Chem286, 7587-7600. PubMed Europe PubMed DOI
Zarrabi,K., Dufour,A., Li,J., Kuscu,C., Pulkoski-Gross,A., Zhi,J., Hu,Y., Sampson,N.S., Zucker,S. and Cao,J.
Inhibition of matrix metalloproteinase 14 (MMP-14)-mediated cancer cell migration
J Biol Chem286, 33167-33177. PubMed Europe PubMed DOI
Zhu,L., Wang,H., Wang,L., Wang,Y., Jiang,K., Li,C., Ma,Q., Gao,S., Wang,L., Li,W., Cai,M., Wang,H., Niu,G., Lee,S., Yang,W., Fang,X. and Chen,X.
High-affinity peptide against MT1-MMP for in vivo tumor imaging
J Control Release150, 248-255. PubMed Europe PubMed DOI L

2010

De Croos,J.N., Roughley,P.J. and Kandel,R.A.
Improved bioengineered cartilage tissue formation following cyclic compression is dependent on upregulation of MT1-MMP
J Orthop Res28, 921-927. PubMed Europe PubMed DOI
Gingras,D. and Beliveau,R.
Emerging concepts in the regulation of membrane-type 1 matrix metalloproteinase activity
Biochim Biophys Acta1803, 142-150. PubMed Europe PubMed DOI
Gioia,M., Fasciglione,G.F., Monaco,S., Iundusi,R., Sbardella,D., Marini,S., Tarantino,U. and Coletta,M.
pH dependence of the enzymatic processing of collagen I by MMP-1 (fibroblast collagenase), MMP-2 (gelatinase A), and MMP-14 ectodomain
J Biol Inorg Chem15, 1219-1232. PubMed Europe PubMed DOI
Golubkov,V.S., Cieplak,P., Chekanov,A.V., Ratnikov,B.I., Aleshin,A.E., Golubkova,N.V., Postnova,T.I., Radichev,I.A., Rozanov,D.V., Zhu,W., Motamedchaboki,K. and Strongin,A.Y.
Internal cleavages of the autoinhibitory prodomain are required for membrane type 1 matrix metalloproteinase activation, although furin cleavage alone generates inactive proteinase
J Biol Chem285, 27726-27736. PubMed Europe PubMed DOI
Gulotta,L.V., Kovacevic,D., Montgomery,S., Ehteshami,J.R., Packer,J.D. and Rodeo,S.A.
Stem cells genetically modified with the developmental gene MT1-MMP improve regeneration of the supraspinatus tendon-to-bone insertion site
Am J Sports Med38, 1429-1437. PubMed Europe PubMed DOI
Itoh,Y.
Metalloproteinase binding proteins: WO2009097397
Expert Opin Ther Pat20, 1091-1095. PubMed Europe PubMed DOI
Koshikawa,N., Mizushima,H., Minegishi,T., Iwamoto,R., Mekada,E. and Seiki,M.
Membrane type 1-matrix metalloproteinase cleaves off the NH2-terminal portion of heparin-binding epidermal growth factor and converts it into a heparin-independent growth factor
Cancer Res70, 6093-6103. PubMed Europe PubMed DOI
Liu,G., Atteridge,C.L., Wang,X., Lundgren,A.D. and Wu,J.D.
The membrane type matrix metalloproteinase MMP14 mediates constitutive shedding of MHC class I chain-related molecule A independent of a disintegrin and metalloproteinases
J Immunol184, 3346-3350. PubMed Europe PubMed DOI
Liu,P., Yang,J., Pei,J., Pei,D. and Wilson,M.J.
Regulation of MT1-MMP activity by beta-catenin in MDCK non-cancer and HT1080 cancer cells
J Cell Physiol225, 810-821. PubMed Europe PubMed DOI
Nyalendo,C., Sartelet,H., Gingras,D. and Beliveau,R.
Inhibition of membrane-type 1 matrix metalloproteinase tyrosine phosphorylation blocks tumor progression in mice
Anticancer Res30, 1887-1895. PubMed Europe PubMed
Riggins,K.S., Mernaugh,G., Su,Y., Quaranta,V., Koshikawa,N., Seiki,M., Pozzi,A. and Zent,R.
MT1-MMP-mediated basement membrane remodeling modulates renal development
Exp Cell Res316, 2993-3005. PubMed Europe PubMed DOI
Roghi,C., Jones,L., Gratian,M., English,W.R. and Murphy,G.
Golgi reassembly stacking protein 55 interacts with membrane-type (MT) 1-matrix metalloprotease (MMP) and furin and plays a role in the activation of the MT1-MMP zymogen
FEBS J277, 3158-3175. PubMed Europe PubMed DOI
Sato,H. and Takino,T.
Coordinate action of membrane-type matrix metalloproteinase-1 (MT1-MMP) and MMP-2 enhances pericellular proteolysis and invasion
Cancer Sci101, 843-847. PubMed Europe PubMed DOI V
Strongin,A.Y.
Proteolytic and non-proteolytic roles of membrane type-1 matrix metalloproteinase in malignancy
Biochim Biophys Acta1803, 133-141. PubMed Europe PubMed DOI

2009

Butler,G.S., Dean,R.A., Smith,D. and Overall,C.M.
Membrane protease degradomics: proteomic identification and quantification of cell surface protease substrates
Methods Mol Biol528, 159-176. PubMed Europe PubMed DOI P
Deshmukh,H.S., McLachlan,A., Atkinson,J.J., Hardie,W.D., Korfhagen,T.R., Dietsch,M., Liu,Y., Di,P.Y., Wesselkamper,S.C., Borchers,M.T. and Leikauf,G.D.
Matrix metalloproteinase-14 mediates a phenotypic shift in the airways to increase mucin production
Am J Respir Crit Care Med180, 834-845. PubMed Europe PubMed DOI
Devy,L., Huang,L., Naa,L., Yanamandra,N., Pieters,H., Frans,N., Chang,E., Tao,Q., Vanhove,M., Lejeune,A., van Gool,R., Sexton,D.J., Kuang,G., Rank,D., Hogan,S., Pazmany,C., Ma,Y.L., Schoonbroodt,S., Nixon,A.E., Ladner,R.C., Hoet,R., Henderikx,P., Tenhoor,C., Rabbani,S.A., Valentino,M.L., Wood,C.R. and Dransfield,D.T.
Selective inhibition of matrix metalloproteinase-14 blocks tumor growth, invasion, and angiogenesis
Cancer Res69, 1517-1526. PubMed Europe PubMed DOI
Gooyit,M., Lee,M., Hesek,D., Boggess,B., Oliver,A.G., Fridman,R., Mobashery,S. and Chang,M.
Synthesis, kinetic characterization and metabolism of diastereomeric 2-(1-(4-phenoxyphenylsulfonyl)ethyl)thiiranes as potent gelatinase and MT1-MMP inhibitors
Chem Biol Drug Des74, 535-546. PubMed Europe PubMed DOI I
Guo,A., Yang,L. and Gu,J.C.
Membrane type-1 metalloproteinase mediates nitric oxide-induced activation of matrix metalloproteinase-13
Orthopedics32, 826-826. PubMed Europe PubMed DOI
Miller,M.C., Manning,H.B., Jain,A., Troeberg,L., Dudhia,J., Essex,D., Sandison,A., Seiki,M., Nanchahal,J., Nagase,H. and Itoh,Y.
Membrane type 1 matrix metalloproteinase is a crucial promoter of synovial invasion in human rheumatoid arthritis
Arthritis Rheum60, 686-697. PubMed Europe PubMed DOI
Moss,N.M., Wu,Y.I., Liu,Y., Munshi,H.G. and Stack,M.S.
Modulation of the membrane type 1 matrix metalloproteinase cytoplasmic tail enhances tumor cell invasion and proliferation in three-dimensional collagen matrices
J Biol Chem284, 19791-19799. PubMed Europe PubMed DOI
Niiya,D., Egawa,N., Sakamoto,T., Kikkawa,Y., Shinkawa,T., Isobe,T., Koshikawa,N. and Seiki,M.
Identification and characterization of Lutheran blood group glycoprotein as a new substrate of membrane-type 1 matrix metalloproteinase 1 (MT1-MMP): a systemic whole cell analysis of MT1-MMP-associating proteins in A431 cells
J Biol Chem284, 27360-27369. PubMed Europe PubMed DOI P
Poincloux,R., Lizarraga,F. and Chavrier,P.
Matrix invasion by tumour cells: a focus on MT1-MMP trafficking to invadopodia
J Cell Sci122, 3015-3024. PubMed Europe PubMed DOI
Radichev,I.A., Remacle,A.G., Sounni,N.E., Shiryaev,S.A., Rozanov,D.V., Zhu,W., Golubkova,N.V., Postnova,T.I., Golubkov,V.S. and Strongin,A.Y.
Biochemical evidence of the interactions of membrane type-1 matrix metalloproteinase (MT1-MMP) with adenine nucleotide translocator (ANT): potential implications linking proteolysis with energy metabolism in cancer cells
Biochem J420, 37-47. PubMed Europe PubMed DOI
Sabeh,F., Shimizu-Hirota,R. and Weiss,S.J.
Protease-dependent versus -independent cancer cell invasion programs: three-dimensional amoeboid movement revisited
J Cell Biol185, 11-19. PubMed Europe PubMed DOI
Sabeh,F., Li,X.Y., Saunders,T.L., Rowe,R.G. and Weiss,S.J.
Secreted versus membrane-anchored collagenases: relative roles in fibroblast-dependent collagenolysis and invasion
J Biol Chem284, 23001-23011. PubMed Europe PubMed DOI
Sakamoto,T. and Seiki,M.
Cytoplasmic tail of MT1-MMP regulates macrophage motility independently from its protease activity
Genes Cells14, 617-626. PubMed Europe PubMed DOI
Sina,A., Lord-Dufour,S. and Annabi,B.
Cell-based evidence for aminopeptidase N/CD13 inhibitor actinonin targeting of MT1-MMP-mediated proMMP-2 activation
Cancer Lett279, 171-176. PubMed Europe PubMed DOI I
Suojanen,J., Salo,T., Koivunen,E., Sorsa,T. and Pirila,E.
A novel and selective membrane type-1 matrix metalloproteinase (MT1-MMP) inhibitor reduces cancer cell motility and tumor growth
Cancer Biol Ther8, 2362-2370. PubMed Europe PubMed I
Wang,X., Wilson,M.J., Slaton,J.W., Sinha,A.A., Ewing,S.L. and Pei,D.
Increased aggressiveness of human prostate PC-3 tumor cells expressing cell surface localized membrane type-1 matrix metalloproteinase (MT1-MMP)
J Androl30, 259-274. PubMed Europe PubMed DOI
Xiong,W., Knispel,R., MacTaggart,J., Greiner,T.C., Weiss,S.J. and Baxter,B.T.
Membrane-type 1 matrix metalloproteinase regulates macrophage-dependent elastolytic activity and aneurysm formation in vivo
J Biol Chem284, 1765-1771. PubMed Europe PubMed DOI

2008

Barbolina,M.V. and Stack,M.S.
Membrane type 1-matrix metalloproteinase: substrate diversity in pericellular proteolysis
Semin Cell Dev Biol19, 24-33. PubMed Europe PubMed DOI V
Cho,J.A., Osenkowski,P., Zhao,H., Kim,S., Toth,M., Cole,K., Aboukameel,A., Saliganan,A., Schuger,L., Bonfil,R.D. and Fridman,R.
The inactive 44-kDa processed form of membrane type 1 matrix metalloproteinase (MT1-MMP) enhances proteolytic activity via regulation of endocytosis of active MT1-MMP
J Biol Chem283, 17391-17405. PubMed Europe PubMed DOI
Coyle,R.C., Latimer,A. and Jessen,J.R.
Membrane-type 1 matrix metalloproteinase regulates cell migration during zebrafish gastrulation: evidence for an interaction with non-canonical Wnt signaling
Exp Cell Res314, 2150-2162. PubMed Europe PubMed DOI K
D'Alessio,S., Ferrari,G., Cinnante,K., Scheerer,W., Galloway,A.C., Roses,D.F., Rozanov,D.V., Remacle,A.G., Oh,E.S., Shiryaev,S.A., Strongin,A.Y., Pintucci,G. and Mignatti,P.
Tissue inhibitor of metalloproteinases-2 binding to membrane-type 1 matrix metalloproteinase induces MAPK activation and cell growth by a non-proteolytic mechanism
J Biol Chem283, 87-99. PubMed Europe PubMed DOI
Ingvarsen,S., Madsen,D.H., Hillig,T., Lund,L.R., Holmbeck,K., Behrendt,N. and Engelholm,L.H.
Dimerization of endogenous MT1-MMP is a regulatory step in the activation of the 72-kDa gelatinase MMP-2 on fibroblasts and fibrosarcoma cells
Biol Chem389, 943-953. PubMed Europe PubMed DOI
Itoh,Y., Ito,N., Nagase,H. and Seiki,M.
The second dimer interface of MT1-MMP, the transmembrane domain, is essential for proMMP-2 activation on the cell surface
J Biol Chem283, 13053-13062. PubMed Europe PubMed DOI
Li,X.Y., Ota,I., Yana,I., Sabeh,F. and Weiss,S.J.
Molecular dissection of the structural machinery underlying the tissue-invasive activity of membrane type-1 matrix metalloproteinase
Mol Biol Cell19, 3221-3233. PubMed Europe PubMed DOI
Nishida,Y., Miyamori,H., Thompson,E.W., Takino,T., Endo,Y. and Sato,H.
Activation of matrix metalloproteinase-2 (MMP-2) by membrane type 1 matrix metalloproteinase through an artificial receptor for proMMP-2 generates active MMP-2
Cancer Res68, 9096-9104. PubMed Europe PubMed DOI
Park,J.H., Park,S.M., Park,S.H., Cho,K.H. and Lee,S.T.
Cleavage and functional loss of human apolipoprotein E by digestion of matrix metalloproteinase-14
Proteomics8, 2926-2935. PubMed Europe PubMed DOI
Schneider,F., Sukhova,G.K., Aikawa,M., Canner,J., Gerdes,N., Tang,S.M., Shi,G.P., Apte,S.S. and Libby,P.
Matrix-metalloproteinase-14 deficiency in bone-marrow-derived cells promotes collagen accumulation in mouse atherosclerotic plaques
Circulation117, 931-939. PubMed Europe PubMed DOI
Shimokawa,H.
Bone-marrow-derived matrix metalloproteinase-14: a novel target for plaque stability
Circulation117, 863-865. PubMed Europe PubMed DOI
Terawaki,S., Kitano,K., Aoyama,M. and Hakoshima,T.
Crystallographic characterization of the radixin FERM domain bound to the cytoplasmic tail of membrane-type 1 matrix metalloproteinase (MT1-MMP)
Acta Crystallograph Sect F Struct Biol Cryst Commun64, 911-913. PubMed Europe PubMed DOI

2007

Abd El-Aziz,S.H., Endo,Y., Miyamaori,H., Takino,T. and Sato,H.
Cleavage of growth differentiation factor 15 (GDF15) by membrane type 1-matrix metalloproteinase abrogates GDF15-mediated suppression of tumor cell growth
Cancer Sci98, 1330-1335. PubMed Europe PubMed DOI
Arroyo,A.G., Genis,L., Gonzalo,P., Matias-Roman,S., Pollan,A. and Galvez,B.G.
Matrix metalloproteinases: new routes to the use of MT1-MMP as a therapeutic target in angiogenesis-related disease
Curr Pharm Des13, 1787-1802. PubMed Europe PubMed DOI
Basile,J.R., Holmbeck,K., Bugge,T.H. and Gutkind,J.S.
MT1-MMP controls tumor-induced angiogenesis through the release of semaphorin 4D
J Biol Chem282, 6899-6905. PubMed Europe PubMed DOI
Currie,J.C., Fortier,S., Sina,A., Galipeau,J., Cao,J. and Annabi,B.
MT1-MMP down-regulates the glucose 6-phosphate transporter expression in marrow stromal cells: a molecular link between pro-MMP-2 activation, chemotaxis, and cell survival
J Biol Chem282, 8142-8149. PubMed Europe PubMed DOI
Gioia,M., Monaco,S., Fasciglione,G.F., Coletti,A., Modesti,A., Marini,S. and Coletta,M.
Characterization of the mechanisms by which gelatinase A, neutrophil collagenase, and membrane-type metalloproteinase MMP-14 recognize collagen I and enzymatically process the two alpha-chains
J Mol Biol368, 1101-1113. PubMed Europe PubMed DOI
Golubkov,V.S., Chekanov,A.V., Shiryaev,S.A., Aleshin,A.E., Ratnikov,B.I., Gawlik,K., Radichev,I., Motamedchaboki,K., Smith,J.W. and Strongin,A.Y.
Proteolysis of the membrane type-1 matrix metalloproteinase prodomain: implications for a two-step proteolytic processing and activation
J Biol Chem282, 36283-36291. PubMed Europe PubMed DOI
Hasebe,T., Hartman,R., Fu,L., Amano,T. and Shi,Y.B.
Evidence for a cooperative role of gelatinase A and membrane type-1 matrix metalloproteinase during Xenopus laevis development
Mech Dev124, 11-22. PubMed Europe PubMed DOI
Hu,N., Zhou,X.W., Fu,H.J., Xing,R.Y., Kong,W. and Zheng,X.F.
Inhibitory effect of antisense RNA on the gene expression of membrane-type 1 matrix metalloproteinase and invasiveness of human gastric carcinoma cells
World Chin J Dig15, 1470-1474.
Lee,H., Sodek,K.L., Hwang,Q., Brown,T.J., Ringuette,M. and Sodek,J.
Phagocytosis of collagen by fibroblasts and invasive cancer cells is mediated by MT1-MMP
Biochem Soc Trans35, 704-706. PubMed Europe PubMed DOI
Sodek,K.L., Ringuette,M.J. and Brown,T.J.
MT1-MMP is the critical determinant of matrix degradation and invasion by ovarian cancer cells
Br J Cancer97, 358-367. PubMed Europe PubMed DOI T
Taniwaki,K., Fukamachi,H., Komori,K., Ohtake,Y., Nonaka,T., Sakamoto,T., Shiomi,T., Okada,Y., Itoh,T., Itohara,S., Seiki,M. and Yana,I.
Stroma-derived matrix metalloproteinase (MMP)-2 promotes membrane type 1-MMP-dependent tumor growth in mice
Cancer Res67, 4311-4319. PubMed Europe PubMed DOI
Wolf,K., Wu,Y.I., Liu,Y., Geiger,J., Tam,E., Overall,C., Stack,M.S. and Friedl,P.
Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion
Nat Cell Biol9, 893-904. PubMed Europe PubMed DOI

2006

[YEAR:10-5-2006]Atkinson,S.J., Roghi,C. and Murphy,G.
MT1-MMP hemopexin domain exchange with MT4-MMP blocks enzyme maturation and trafficking to the plasma membrane in MCF7 cells
Biochem J398, 15-22. PubMed Europe PubMed DOI
Chun,T.H., Hotary,K.B., Sabeh,F., Saltiel,A.R., Allen,E.D. and Weiss,S.J.
A pericellular collagenase directs the 3-dimensional development of white adipose tissue
Cell125, 577-591. PubMed Europe PubMed DOI
Egawa,N., Koshikawa,N., Tomari,T., Nabeshima,K., Isobe,T. and Seiki,M.
Membrane type 1 matrix metalloproteinase (MT1-MMP/MMP-14) cleaves and releases a 22-kDa extracellular matrix metalloproteinase inducer (EMMPRIN) fragment from tumor cells
J Biol Chem281, 37576-37585. PubMed Europe PubMed DOI P
Genis,L., Galvez,B.G., Gonzalo,P. and Arroyo,A.G.
MT1-MMP: universal or particular player in angiogenesis?
Cancer Metastasis Rev25, 77-86. PubMed Europe PubMed DOI V
[YEAR:1-11-2006]Golubkov,V.S., Chekanov,A.V., Savinov,A.Y., Rozanov,D.V., Golubkova,N.V. and Strongin,A.Y.
Membrane type-1 matrix metalloproteinase confers aneuploidy and tumorigenicity on mammary epithelial cells
Cancer Res66, 10460-10465. PubMed Europe PubMed DOI
[YEAR:18-1-2006]Hasebe,T., Hartman,R., Matsuda,H. and Shi,Y.B.
Spatial and temporal expression profiles suggest the involvement of gelatinase A and membrane type 1 matrix metalloproteinase in amphibian metamorphosis
Cell Tissue Res324, 105-116. PubMed Europe PubMed DOI
Hotary,K., Li,X.Y., Allen,E., Stevens,S.L. and Weiss,S.J.
A cancer cell metalloprotease triad regulates the basement membrane transmigration program
Genes Dev20, 2673-2686. PubMed Europe PubMed DOI
[YEAR:26-5-2006]Itoh,Y. and Seiki,M.
MT1-MMP: a potent modifier of pericellular microenvironment
J Cell Physiol206, 1-8. PubMed Europe PubMed DOI V
Itoh,Y., Ito,N., Nagase,H., Evans,R.D., Bird,S.A. and Seiki,M.
Cell surface collagenolysis requires homodimerization of the membrane-bound collagenase MT1-MMP
Mol Biol Cell17, 5390-5399. PubMed Europe PubMed DOI
Itoh,Y.
MT1-MMP: a key regulator of cell migration in tissue
IUBMB Life58, 589-596. PubMed Europe PubMed DOI
[YEAR:15-9-2006]Lee,H., Overall,C.M., McCulloch,C.A. and Sodek,J.
A critical role for the membrane-type 1 matrix metalloproteinase in collagen phagocytosis
Mol Biol Cell17, 4812-4826. PubMed Europe PubMed DOI
[YEAR:24-4-2006]Remacle,A.G., Rozanov,D.V., Fugere,M., Day,R. and Strongin,A.Y.
Furin regulates the intracellular activation and the uptake rate of cell surface-associated MT1-MMP
Oncogene25, 5648-5655. PubMed Europe PubMed DOI
[YEAR:20-4-2006]Remacle,A.G., Chekanov,A.V., Golubkov,V.S., Savinov,A.Y., Rozanov,D.V. and Strongin,A.Y.
O-glycosylation regulates autolysis of cellular membrane type-1 matrix metalloproteinase (MT1-MMP)
J Biol Chem281, 16897-16905. PubMed Europe PubMed DOI
[YEAR:22-9-2006]Toth,M., Sohail,A., Mobashery,S. and Fridman,R.
MT1-MMP shedding involves an ADAM and is independent of its localization in lipid rafts
Biochem Biophys Res Commun350, 377-384. PubMed Europe PubMed DOI

2005

[YEAR:9-6-2005]Anilkumar,N., Uekita,T., Couchman,J.R., Nagase,H., Seiki,M. and Itoh,Y.
Palmitoylation at Cys574 is essential for MT1-MMP to promote cell migration
FASEB J19, 1326-1328. PubMed Europe PubMed DOI
[YEAR:28-2-2005]Atkinson,J.J., Holmbeck,K., Yamada,S., Birkedal-Hansen,H., Parks,W.C. and Senior,R.M.
Membrane-type 1 matrix metalloproteinase is required for normal alveolar development
Dev Dyn232, 1079-1090. PubMed Europe PubMed DOI K
Bair,E.L., Chen,M.L., McDaniel,K., Sekiguchi,K., Cress,A.E., Nagle,R.B. and Bowden,G.T.
Membrane type 1 matrix metalloprotease cleaves laminin-10 and promotes prostate cancer cell migration
Neoplasia7, 380-389. PubMed Europe PubMed DOI P
[YEAR:8-3-2005]Deschamps,A.M., Yarbrough,W.M., Squires,C.E., Allen,R.A., McClister,D.M., Dowdy,K.B., McLean,J.E., Mingoia,J.T., Sample,J.A., Mukherjee,R. and Spinale,F.G.
Trafficking of the membrane type-1 matrix metalloproteinase in ischemia and reperfusion: relation to interstitial membrane type-1 matrix metalloproteinase activity
Circulation111, 1166-1174. PubMed Europe PubMed DOI
Filippov,S., Koenig,G.C., Chun,T.H., Hotary,K.B., Ota,I., Bugge,T.H., Roberts,J.D., Fay,W.P., Birkedal-Hansen,H., Holmbeck,K., Sabeh,F., Allen,E.D. and Weiss,S.J.
MT1-matrix metalloproteinase directs arterial wall invasion and neointima formation by vascular smooth muscle cells
J Exp Med202, 663-671. PubMed Europe PubMed DOI
[YEAR:4-5-2005]Golubkov,V.S., Boyd,S., Savinov,A.Y., Chekanov,A.V., Osterman,A.L., Remacle,A., Rozanov,D.V., Doxsey,S.J. and Strongin,A.Y.
Membrane type-1 matrix metalloproteinase (MT1-MMP) exhibits an important intracellular cleavage function and causes chromosome instability
J Biol Chem280, 25079-25086. PubMed Europe PubMed DOI
Irie,K., Komori,K., Seiki,M., Tsuruga,E., Sakakura,Y., Kaku,T. and Yajima,T.
Impaired alveolization in mice deficient in membrane-type matrix metalloproteinase 1 (MT1-MMP)
Med Mol Morphol38, 43-46. PubMed Europe PubMed DOI K
[YEAR:3-11-2005]Koshikawa,N., Minegishi,T., Sharabi,A., Quaranta,V. and Seiki,M.
Membrane-type matrix metalloproteinase-1 (MT1-MMP) is a processing enzyme for human laminin gamma 2 chain
J Biol Chem280, 88-93. PubMed Europe PubMed DOI
Oblander,S.A., Zhou,Z., Galvez,B.G., Starcher,B., Shannon,J.M., Durbeej,M., Arroyo,A.G., Tryggvason,K. and Apte,S.S.
Distinctive functions of membrane type 1 matrix-metalloprotease (MT1-MMP or MMP-14) in lung and submandibular gland development are independent of its role in pro-MMP-2 activation
Dev Biol277, 255-269. PubMed Europe PubMed DOI
[YEAR:10-11-2005]Page,L.J., Suk,J.Y., Huff,M.E., Lim,H.J., Venable,J., Yates,J., Kelly,J.W. and Balch,W.E.
Metalloendoprotease cleavage triggers gelsolin amyloidogenesis
EMBO J24, 4124-4132. PubMed Europe PubMed DOI
[YEAR:1-3-2005]Rossello,A., Nuti,E., Carelli,P., Orlandini,E., Macchia,M., Nencetti,S., Zandomeneghi,M., Balzano,F., Uccello Barretta,G., Albini,A., Benelli,R., Cercignani,G., Murphy,G. and Balsamo,A.
N-i-Propoxy-N-biphenylsulfonylaminobutylhydroxamic acids as potent and selective inhibitors of MMP-2 and MT1-MMP
Bioorg Med Chem Lett15, 1321-1326. PubMed Europe PubMed DOI I
[YEAR:8-6-2005]Savinov,A.Y., Rozanov,D.V., Golubkov,V.S., Wong,F.S. and Strongin,A.Y.
Inhibition of membrane type-1 matrix metalloproteinase by cancer drugs interferes with the homing of diabetogenic T cells into the pancreas
J Biol Chem280, 27755-27758. PubMed Europe PubMed DOI I
[YEAR:22-11-2005]Suenaga,N., Mori,H., Itoh,Y. and Seiki,M.
CD44 binding through the hemopexin-like domain is critical for its shedding by membrane-type 1 matrix metalloproteinase
Oncogene24, 859-868. PubMed Europe PubMed DOI
[YEAR:24-11-2005]Toth,M., Osenkowski,P., Hesek,D., Brown,S., Meroueh,S., Sakr,W., Mobashery,S. and Fridman,R.
Cleavage at the stem region releases an active ectodomain of the membrane type 1 matrix metalloproteinase
Biochem J387, 497-506. PubMed Europe PubMed DOI
Wu,M., Shi,Y., Xi,L., Li,Q., Liao,G.N., Han,Z.Q., Lu,Y.P. and Ma,D.
Construction of antisense MT1-MMP vector and its inhibitory effects on invasion of human ovarian cancer cells
J Huazhong Univ Sci Technolog Med Sci25, 715-717. PubMed Europe PubMed K

2004

[YEAR:2-4-2004]Cao,J., Kozarekar,P., Pavlaki,M., Chiarelli,C., Bahou,W.F. and Zucker,S.
Distinct roles for the catalytic and hemopexin domains of membrane type 1-matrix metalloproteinase in substrate degradation and cell migration
J Biol Chem279, 14129-14139. PubMed Europe PubMed DOI
Holmbeck,K., Bianco,P., Yamada,S. and Birkedal-Hansen,H.
MT1-MMP: a tethered collagenase
J Cell Physiol200, 11-19. PubMed Europe PubMed DOI K
[YEAR:1-2-2004]Hurst,D.R., Schwartz,M.A., Ghaffari,M.A., Jin,Y., Tschesche,H., Fields,G.B. and Sang,Q.X.
Catalytic- and ecto-domains of membrane type 1-matrix metalloproteinase have similar inhibition profiles but distinct endopeptidase activities
Biochem J377, 775-779. PubMed Europe PubMed DOI
[YEAR:1-10-2004]Hwang,I.K., Park,S.M., Kim,S.Y. and Lee,S.T.
A proteomic approach to identify substrates of matrix metalloproteinase-14 in human plasma
Biochim Biophys Acta1702, 79-87. PubMed Europe PubMed DOI
Iida,J., Wilhelmson,K.L., Price,M.A., Wilson,C.M., Pei,D., Furcht,L.T. and McCarthy,J.B.
Membrane type-1 matrix metalloproteinase promotes human melanoma invasion and growth
J Invest Dermatol122, 167-176. PubMed Europe PubMed DOI
Itoh,Y. and Seiki,M.
MT1-MMP: an enzyme with multidimensional regulation
Trends Biochem Sci29, 285-289. PubMed Europe PubMed DOI
Itoh,Y. and Seiki,M.
Membrane-type matrix metalloproteinase 1
[ISSN:0-12-079610-4]2, 544-549. V
[YEAR:1-10-2004]Li,Y., Aoki,T., Mori,Y., Ahmad,M., Miyamori,H., Takino,T. and Sato,H.
Cleavage of lumican by membrane-type matrix metalloproteinase-1 abrogates this proteoglycan-mediated suppression of tumor cell colony formation in soft agar
Cancer Res64, 7058-7064. PubMed Europe PubMed DOI
[YEAR:15-12-2004]Mazzone,M., Baldassarre,M., Beznoussenko,G., Giacchetti,G., Cao,J., Zucker,S., Luini,A. and Buccione,R.
Intracellular processing and activation of membrane type 1 matrix metalloprotease depends on its partitioning into lipid domains
J Cell Sci117, 6275-6287. PubMed Europe PubMed DOI
[YEAR:14-9-2004]Minond,D., Lauer-Fields,J.L., Nagase,H. and Fields,G.B.
Matrix metalloproteinase triple-helical peptidase activities are differentially regulated by substrate stability
Biochemistry43, 11474-11481. PubMed Europe PubMed DOI
Mirastschijski,U., Zhou,Z., Rollman,O., Tryggvason,K. and Agren,M.S.
Wound healing in membrane-type-1 matrix metalloproteinase-deficient mice
J Invest Dermatol123, 600-602. PubMed Europe PubMed DOI
[YEAR:28-9-2004]Oak,M.H., El Bedoui,J., Anglard,P. and Schini-Kerth,V.B.
Red wine polyphenolic compounds strongly inhibit pro-matrix metalloproteinase-2 expression and its activation in response to thrombin via direct inhibition of membrane type 1-matrix metalloproteinase in vascular smooth muscle cells
Circulation110, 1861-1867. PubMed Europe PubMed DOI
[YEAR:5-4-2004]Oh,J., Takahashi,R., Adachi,E., Kondo,S., Kuratomi,S., Noma,A., Alexander,D.B., Motoda,H., Okada,A., Seiki,M., Itoh,T., Itohara,S., Takahashi,C. and Noda,M.
Mutations in two matrix metalloproteinase genes, MMP-2 and MT1-MMP, are synthetic lethal in mice
Oncogene23, 5041-5048. PubMed Europe PubMed DOI K
[YEAR:14-9-2004]Rozanov,D.V., Savinov,A.Y., Golubkov,V.S., Postnova,T.I., Remacle,A., Tomlinson,S. and Strongin,A.Y.
Cellular membrane type-1 matrix metalloproteinase (MT1-MMP) cleaves C3b, an essential component of the complement system
J Biol Chem279, 46551-46557. PubMed Europe PubMed DOI
[YEAR:16-9-2004]Rozanov,D.V., Sikora,S., Godzik,A., Postnova,T.I., Golubkov,V., Savinov,A., Tomlinson,S. and Strongin,A.Y.
Non-proteolytic, receptor/ligand interactions associate cellular membrane type-1 matrix metalloproteinase with the complement component C1q
J Biol Chem279, 50321-50328. PubMed Europe PubMed DOI
[YEAR:20-9-2004]Wang,P., Nie,J. and Pei,D.
The hemopexin domain of membrane-type matrix metalloproteinase-1 (MT1-MMP) Is not required for its activation of proMMP2 on cell surface but is essential for MT1-MMP-mediated invasion in three-dimensional type I collagen
J Biol Chem279, 51148-51155. PubMed Europe PubMed DOI
[YEAR:11-12-2004]Wu,Y.I., Munshi,H.G., Sen,R., Snipas,S.J., Salvesen,G.S., Fridman,R. and Stack,M.S.
Glycosylation broadens the substrate profile of membrane type 1 matrix metalloproteinase
J Biol Chem279, 8278-8289. PubMed Europe PubMed DOI
[YEAR:16-12-2004]Zhao,H., Bernardo,M.M., Osenkowski,P., Sohail,A., Pei,D., Nagase,H., Kashiwagi,M., Soloway,P.D., DeClerck,Y.A. and Fridman,R.
Differential inhibition of membrane type 3 (MT3)-matrix metalloproteinase (MMP) and MT1-MMP by tissue inhibitor of metalloproteinase (TIMP)-2 and TIMP-3 rgulates pro-MMP-2 activation
J Biol Chem279, 8592-8601. PubMed Europe PubMed DOI I

2003

[YEAR:15-11-2003]Baciu,P.C., Suleiman,E.A., Deryugina,E.I. and Strongin,A.Y.
Membrane type-1 matrix metalloproteinase (MT1-MMP) processing of pro-alphav integrin regulates cross-talk between alphavbeta3 and alpha2beta1 integrins in breast carcinoma cells
Exp Cell Res291, 167-175. PubMed Europe PubMed DOI
Bartlett,J.D., Zhou,Z., Skobe,Z., Dobeck,J.M. and Tryggvason,K.
Delayed tooth eruption in membrane type-1 matrix metalloproteinase deficient mice
Connect Tissue Res44 Suppl 1, 300-304. PubMed Europe PubMed K
Beertsen,W., Holmbeck,K., Niehof,A., Bianco,P., Chrysovergis,K., Birkedal-Hansen,H. and Everts,V.
Inhibition of molar eruption and root elongation in MT1-MMP-deficient mice
Connect Tissue Res44 Suppl 1, 298-299. PubMed Europe PubMed K
[YEAR:17-10-2003]Endo,K., Takino,T., Miyamori,H., Kinsen,H., Yoshizaki,T., Furukawa,M. and Sato,H.
Cleavage of syndecan-1 by membrane type matrix metalloproteinase-1 stimulates cell migration
J Biol Chem278, 40764-40770. PubMed Europe PubMed DOI
[YEAR:3-6-2003]Higashi,S. and Miyazaki,K.
Novel processing of beta-amyloid precursor protein catalyzed by membrane type 1 matrix metalloproteinase releases a fragment lacking the inhibitor domain against gelatinase A
Biochemistry42, 6514-6526. PubMed Europe PubMed DOI
[YEAR:10-11-2003]Holmbeck,K., Bianco,P., Chrysovergis,K., Yamada,S. and Birkedal-Hansen,H.
MT1-MMP-dependent, apoptotic remodeling of unmineralized cartilage: a critical process in skeletal growth
J Cell Biol163, 661-671. PubMed Europe PubMed DOI
[YEAR:11-7-2003]Hotary,K.B., Allen,E.D., Brooks,P.C., Datta,N.S., Long,M.W. and Weiss,S.J.
Membrane type I matrix metalloproteinase usurps tumor growth control imposed by the three-dimensional extracellular matrix
Cell114, 33-45. PubMed Europe PubMed DOI
[YEAR:10-10-2003]Lee,M.H., Rapti,M. and Murphy,G.
Unveiling the surface epitopes that render tissue inhibitor of metalloproteinase-1 inactive against membrane type 1-matrix metalloproteinase
J Biol Chem278, 40224-40230. PubMed Europe PubMed DOI
Luo,X.H., Liao,E.Y., Liao,H.J., Jin,Y., Zhou,H.D. and Huang,G.
Recombinant matrix metalloproteinase-14 catalytic domain induces apoptosis in human osteoblastic SaOS-2 cells
J Endocrinol Invest26, 1111-1116. PubMed Europe PubMed
[YEAR:1-7-2003]Maquoi,E., Peyrollier,K., Noel,A., Foidart,J.M. and Frankenne,F.
Regulation of membrane-type 1 matrix metalloproteinase activity by vacuolar H+-ATPases
Biochem J373, 19-24. PubMed Europe PubMed DOI
[YEAR:1-10-2003]Remacle,A., Murphy,G. and Roghi,C.
Membrane type I-matrix metalloproteinase (MT1-MMP) is internalised by two different pathways and is recycled to the cell surface
J Cell Sci116, 3905-3916. PubMed Europe PubMed DOI
[YEAR:8-5-2003]Seiki,M.
Membrane-type 1 matrix metalloproteinase: a key enzyme for tumor invasion
Cancer Lett194, 1-11. PubMed Europe PubMed DOI
[YEAR:1-5-2003]Udayakumar,T.S., Chen,M.L., Bair,E.L., Von Bredow,D.C., Cress,A.E., Nagle,R.B. and Bowden,G.T.
Membrane type-1-matrix metalloproteinase expressed by prostate carcinoma cells cleaves human laminin-5 beta3 chain and induces cell migration
Cancer Res63, 2292-2299. PubMed Europe PubMed

2002

Fukui,N., McAlinden,A., Zhu,Y., Crouch,E., Broekelmann,T.J., Mecham,R.P. and Sandell,L.J.
Processing of type II procollagen amino propeptide by matrix metalloproteinases
J Biol Chem277, 2193-2201. PubMed Europe PubMed DOI
[YEAR:4-12-2002]Knauper,V., Bailey,L., Worley,J.R., Soloway,P., Patterson,M.L. and Murphy,G.
Cellular activation of proMMP-13 by MT1-MMP depends on the C-terminal domain of MMP-13
FEBS Lett532, 127-130. PubMed Europe PubMed DOI
[YEAR:28-6-2002]Kridel,S.J., Sawai,H., Ratnikov,B.I., Chen,E.I., Li,W., Godzik,A., Strongin,A.Y. and Smith,J.W.
A unique substrate binding mode discriminates membrane type-1 matrix metalloproteinase from other matrix metalloproteinases
J Biol Chem277, 23788-23793. PubMed Europe PubMed DOI
Lafleur,M.A., Handsley,M.M., Knauper,V., Murphy,G. and Edwards,D.R.
Endothelial tubulogenesis within fibrin gels specifically requires the activity of membrane-type-matrix metalloproteinases (MT-MMPs)
J Cell Sci115, 3427-3438. PubMed Europe PubMed
Lehti,K., Lohi,J., Juntunen,M.M., Pei,D. and Keski-Oja,J.
Oligomerization through hemopexin and cytoplasmic domains regulates the activity and turnover of membrane-type 1 matrix metalloproteinase
J Biol Chem277, 8440-8448. PubMed Europe PubMed DOI
Palosaari,H., Ding,Y., Larmas,M., Sorsa,T., Bartlett,J.D., Salo,T. and Tjaderhane,L.
Regulation and interactions of MT1-MMP and MMP-20 in human odontoblasts and pulp tissue in vitro
J Dent Res81, 354-359. PubMed Europe PubMed
[YEAR:1-3-2002]Ratnikov,B.I., Rozanov,D.V., Postnova,T.I., Baciu,P.G., Zhang,H., DiScipio,R.G., Chestukhina,G.G., Smith,J.W., Deryugina,E.I. and Strongin,A.Y.
An alternative processing of integrin alpha(v) subunit in tumor cells by membrane type-1 matrix metalloproteinase
J Biol Chem277, 7377-7385. PubMed Europe PubMed DOI
[YEAR:11-9-2002]Rozanov,D.V., Ghebrehiwet,B., Ratnikov,B., Monosov,E.Z., Deryugina,E.I. and Strongin,A.Y.
The cytoplasmic tail peptide sequence of membrane type-1 matrix metalloproteinase (MT1-MMP) directly binds to gC1qR, a compartment-specific chaperone-like regulatory protein
FEBS Lett527, 51-57. PubMed Europe PubMed DOI
[YEAR:15-3-2002]Rozanov,D.V., Ghebrehiwet,B., Postnova,T.I., Eichinger,A., Deryugina,E.I. and Strongin,A.Y.
The hemopexin-like C-terminal domain of membrane type 1 matrix metalloproteinase regulates proteolysis of a multifunctional protein, gC1qR
J Biol Chem277, 9318-9325. PubMed Europe PubMed DOI
[YEAR:11-10-2002]Tam,E.M., Wu,Y.I., Butler,G.S., Stack,M.S. and Overall,C.M.
Collagen binding properties of the membrane type-1 matrix metalloproteinase (MT1-MMP) hemopexin C domain. The ectodomain of the 44-kDa autocatalytic product of MT1-MMP inhibits cell invasion by disrupting native type I collagen cleavage
J Biol Chem277, 39005-39014. PubMed Europe PubMed DOI
[YEAR:19-7-2002]Toth,M., Hernandez-Barrantes,S., Osenkowski,P., Bernardo,M.M., Gervasi,D.C., Shimura,Y., Meroueh,O., Kotra,L.P., Galvez,B.G., Arroyo,A.G., Mobashery,S. and Fridman,R.
Complex pattern of membrane type 1 matrix metalloproteinase shedding. Regulation by autocatalytic cells surface inactivation of active enzyme
J Biol Chem277, 26340-26350. PubMed Europe PubMed DOI

2001

[YEAR:2-3-2001]Atkinson,S.J., Patterson,M.L., Butler,M.J. and Murphy,G.
Membrane type 1 matrix metalloproteinase and gelatinase A synergistically degrade type 1 collagen in a cell model
FEBS Lett491, 222-226. PubMed Europe PubMed DOI
[YEAR:25-5-2001]Belkin,A.M., Akimov,S.S., Zaritskaya,L.S., Ratnikov,B.I., Deryugina,E.I. and Strongin,A.Y.
Matrix-dependent proteolysis of surface transglutaminase by membrane-type metalloproteinase regulates cancer cell adhesion and locomotion
J Biol Chem276, 18415-18422. PubMed Europe PubMed DOI
[YEAR:1-5-2001]Bigg,H.F., Morrison,C.J., Butler,G.S., Bogoyevitch,M.A., Wang,Z.P., Soloway,P.D. and Overall,C.M.
Tissue inhibitor of metalloproteinases-4 inhibits but does not support the activation of gelatinase A via efficient inhibition of membrane type 1-matrix metalloproteinase
Cancer Res61, 3610-3618. PubMed Europe PubMed
[YEAR:15-2-2001]Deryugina,E.I., Ratnikov,B., Monosov,E., Postnova,T.I., DiScipio,R., Smith,J.W. and Strongin,A.Y.
MT1-MMP initiates activation of pro-MMP-2 and integrin alphavbeta3 promotes maturation of MMP-2 in breast carcinoma cells
Exp Cell Res263, 209-223. PubMed Europe PubMed DOI
Gilles,C., Polette,M., Coraux,C., Tournier,J.M., Meneguzzi,G., Munaut,C., Volders,L., Rousselle,P., Birembaut,P. and Foidart,J.M.
Contribution of MT1-MMP and of human laminin-5 gamma2 chain degradation to mammary epithelial cell migration
J Cell Sci114, 2967-2976. PubMed Europe PubMed
Han,Y.P., Tuan,T.L., Wu,H., Hughes,M. and Garner,W.L.
TNF-alpha stimulates activation of pro-MMP2 in human skin through NF-(kappa)B mediated induction of MT1-MMP
J Cell Sci114, 131-139. PubMed Europe PubMed
[YEAR:3-9-2001]Itoh,Y., Takamura,A., Ito,N., Maru,Y., Sato,H., Suenaga,N., Aoki,T. and Seiki,M.
Homophilic complex formation of MT1-MMP facilitates proMMP-2 activation on the cell surface and promotes tumor cell invasion
EMBO J20, 4782-4793. PubMed Europe PubMed DOI
[YEAR:28-5-2001]Kajita,M., Itoh,Y., Chiba,T., Mori,H., Okada,A., Kinoh,H. and Seiki,M.
Membrane-type 1 matrix metalloproteinase cleaves CD44 and promotes cell migration
J Cell Biol153, 893-904. PubMed Europe PubMed DOI
[YEAR:13-7-2001]Rozanov,D.V., Deryugina,E.I., Ratnikov,B.I., Monosov,E.Z., Marchenko,G.N., Quigley,J.P. and Strongin,A.Y.
Mutation analysis of membrane type-1 matrix metalloproteinase (MT1-MMP). The role of the cytoplasmic tail Cys(574), the active site Glu(240), and furin cleavage motifs in oligomerization, processing, and self-proteolysis of MT1-MMP expressed in breast carcinoma cells
J Biol Chem276, 25705-25714. PubMed Europe PubMed DOI
Ruangpanit,N., Chan,D., Holmbeck,K., Birkedal-Hansen,H., Polarek,J., Yang,C., Bateman,J.F. and Thompson,E.W.
Gelatinase A (MMP-2) activation by skin fibroblasts: dependence on MT1-MMP expression and fibrillar collagen form
Matrix Biol20, 193-203. PubMed Europe PubMed DOI
[YEAR:24-12-2001]Uekita,T., Itoh,Y., Yana,I., Ohno,H. and Seiki,M.
Cytoplasmic tail-dependent internalization of membrane-type 1 matrix metalloproteinase is important for its invasion-promoting activity
J Cell Biol155, 1345-1356. PubMed Europe PubMed DOI
[YEAR:31-8-2001]Williamson,R.A., Hutton,M., Vogt,G., Rapti,M., Knauper,V., Carr,M.D. and Murphy,G.
Tyrosine 36 plays a critical role in the interaction of the AB loop of tissue inhibitor of metalloproteinases-2 with matrix metalloproteinase-14
J Biol Chem276, 32966-32970. PubMed Europe PubMed DOI
[YEAR:11-5-2001]Zhuge,Y. and Xu,J.
Rac1 mediates type I collagen-dependent MMP-2 activation: role in cell invasion across collagen barrier
J Biol Chem276, 16248-16256. PubMed Europe PubMed

2000

[YEAR:12-6-2000]Hotary,K., Allen,E., Punturieri,A., Yana,I. and Weiss,S.J.
Regulation of cell invasion and morphogenesis in a three-dimensional type I collagen matrix by membrane-type matrix metalloproteinases 1, 2, and 3
J Cell Biol149, 1309-1323. PubMed Europe PubMed DOI
[YEAR:19-5-2000]Lehti,K., Valtanen,H., Wickstrom,S.A., Lohi,J. and Keski-Oja,J.
Regulation of membrane-type-1 matrix metalloproteinase activity by its cytoplasmic domain
J Biol Chem275, 15006-15013. PubMed Europe PubMed DOI
[YEAR:15-12-2000]Overall,C.M., Tam,E., McQuibban,G.A., Morrison,C., Wallon,U.M., Bigg,H.F., King,A.E. and Roberts,C.R.
Domain interactions in the gelatinase A.TIMP-2.MT1-MMP activation complex. The ectodomain of the 44-kDa form of membrane type-1 matrix metalloproteinase does not modulate gelatinase A activation
J Biol Chem275, 39497-39506. PubMed Europe PubMed DOI
Pap,T., Shigeyama,Y., Kuchen,S., Fernihough,J.K., Simmen,B., Gay,R.E., Billingham,M. and Gay,S.
Differential expression pattern of membrane-type matrix metalloproteinases in rheumatoid arthritis
Arthritis Rheum43, 1226-1232. PubMed Europe PubMed DOI
Roderfeld,M., Buttner,F.H., Bartnik,E. and Tschesche,H.
Expression of human membrane type 1 matrix metalloproteinase in Pichia pastoris
Protein Expr Purif19, 369-374. PubMed Europe PubMed DOI E
[YEAR:29-12-2000]Toth,M., Bernardo,M.M., Gervasi,D.C., Soloway,P.D., Wang,Z., Bigg,H.F., Overall,C.M., DeClerck,Y.A., Tschesche,H., Cher,M.L., Brown,S., Mobashery,S. and Fridman,R.
Tissue inhibitor of metalloproteinase (TIMP)-2 acts synergistically with synthetic matrix metalloproteinase (MMP) inhibitors but not with TIMP-4 to enhance the (Membrane type 1)-MMP-dependent activation of pro-MMP-2
J Biol Chem275, 41415-41423. PubMed Europe PubMed DOI
Valtanen,H., Lehti,K., Lohi,J. and Keski-Oja,J.
Expression and purification of soluble and inactive mutant forms of membrane type 1 matrix metalloproteinase
Protein Expr Purif19, 66-73. PubMed Europe PubMed DOI E
Yana,I. and Weiss,S.J.
Regulation of membrane type-1 matrix metalloproteinase activation by proprotein convertases
Mol Biol Cell11, 2387-2401. PubMed Europe PubMed
Yonemura,Y., Endo,Y., Takino,T., Sakamoto,K., Bandou,E., Kinoshita,K., Fushida,S., Miwa,K., Sugiyama,K. and Sasaki,T.
Membrane-type 1 matrix metalloproteinase enhances lymph node metastasis of gastric cancer
Clin Exp Metastasis18, 321-327. PubMed Europe PubMed DOI
[YEAR:11-4-2000]Zhou,Z., Apte,S.S., Soininen,R., Cao,R., Baaklini,G.Y., Rauser,R.W., Wang,J., Cao,Y. and Tryggvason,K.
Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I
Proc Natl Acad Sci U S A97, 4052-4057. PubMed Europe PubMed DOI

1999

[YEAR:1-10-1999]Holmbeck,K., Bianco,P., Caterina,J., Yamada,S., Kromer,M., Kuznetsov,S.A., Mankani,M., Robey,P.G., Poole,A.R., Pidoux,I., Ward,J.M. and Birkedal-Hansen,H.
MT1-MMP-deficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnover
Cell99, 81-92. PubMed Europe PubMed DOI
Kanwar,Y.S., Ota,K., Yang,Q., Wada,J., Kashihara,N., Tian,Y. and Wallner,E.I.
Role of membrane-type matrix metalloproteinase 1 (MT-1-MMP), MMP-2, and its inhibitor in nephrogenesis
Am J Physiol277, F934-F947. PubMed Europe PubMed
[YEAR:20-12-1999]Ohkubo,S., Miyadera,K., Sugimoto,Y., Matsuo,K., Wierzba,K. and Yamada,Y.
Identification of substrate sequences for membrane type-1 matrix metalloproteinase using bacteriophage peptide display library
Biochem Biophys Res Commun266, 308-313. PubMed Europe PubMed DOI

1998

[YEAR:1-7-1998]Buttner,F.H., Hughes,C.E., Margerie,D., Lichte,A., Tschesche,H., Caterson,B. and Bartnik,E.
Membrane type 1 matrix metalloproteinase (MT1-MMP) cleaves the recombinant aggrecan substrate rAgg1mut at the 'aggrecanase' and the MMP sites. Characterization of MT1-MMP catabolic activities on the interglobular domain of aggrecan
Biochem J333, 159-165. PubMed Europe PubMed
[YEAR:25-12-1998]Cao,J., Drews,M., Lee,H.M., Conner,C., Bahou,W.F. and Zucker,S.
The propeptide domain of membrane type 1 matrix metalloproteinase is required for binding of tissue inhibitor of metalloproteinases and for activation of pro-gelatinase A
J Biol Chem273, 34745-34752. PubMed Europe PubMed DOI
[YEAR:9-1-1998]d'Ortho,M.P., Stanton,H., Butler,M., Atkinson,S.J., Murphy,G. and Hembry,R.M.
MT1-MMP on the cell surface causes focal degradation of gelatin films
FEBS Lett421, 159-164. PubMed Europe PubMed DOI
[YEAR:1-9-1998]Fernandez-Catalan,C., Bode,W., Huber,R., Turk,D., Calvete,J.J., Lichte,A., Tschesche,H. and Maskos,K.
Crystal structure of the complex formed by the membrane type 1-matrix metalloproteinase with the tissue inhibitor of metalloproteinases-2, the soluble progelatinase A receptor
EMBO J17, 5238-5248. PubMed Europe PubMed DOI S
[YEAR:3-7-1998]Fosang,A.J., Last,K., Fujii,Y., Seiki,M. and Okada,Y.
Membrane-type 1 MMP (MMP-14) cleaves at three sites in the aggrecan interglobular domain
FEBS Lett430, 186-190. PubMed Europe PubMed DOI
Hayashi,K., Osada,S., Shofuda,K., Horikoshi,S., Shirato,I. and Tomino,Y.
Enhanced expression of membrane type-1 matrix metalloproteinase in mesangial proliferative glomerulonephritis
J Am Soc Nephrol9, 2262-2271. PubMed Europe PubMed
[YEAR:26-6-1998]Kinoshita,T., Sato,H., Okada,A., Ohuchi,E., Imai,K., Okada,Y. and Seiki,M.
TIMP-2 promotes activation of progelatinase a by membrane-type 1 matrix metalloproteinase immobilized on agarose beads
J Biol Chem273, 16098-16103. PubMed Europe PubMed DOI
[YEAR:1-9-1998]Lehti,K., Lohi,J., Valtanen,H. and Keski-Oja,J.
Proteolytic processing of membrane-type-1 matrix metalloproteinase is associated with gelatinase A activation at the cell surface
Biochem J334, 345-353. PubMed Europe PubMed
[YEAR:30-1-1998]Mucha,A., Cuniasse,P., Kannan,R., Beau,F., Yiotakis,A., Basset,P. and Dive,V.
Membrane type-1 matrix metalloprotease and stromelysin-3 cleave more efficiently synthetic substrates containing unusual amino acids in their P1' positions
J Biol Chem273, 2763-2768. PubMed Europe PubMed DOI

1997

Apte,S.S., Fukai,N., Beier,D.R. and Olsen,B.R.
The matrix metalloproteinase-14 (MMP-14) gene is structurally distinct from other MMP genes and is co-expressed with the TIMP-2 gene during mouse embryogenesis
J Biol Chem272, 25511-25517. PubMed Europe PubMed DOI
[YEAR:15-12-1997]d'Ortho,M.P., Will,H., Atkinson,S., Butler,G., Messent,A., Gavrilovic,J., Smith,B., Timpl,R., Zardi,L. and Murphy,G.
Membrane-type matrix metalloproteinases 1 and 2 exhibit broad-spectrum proteolytic capacities comparable to many matrix metalloproteinases
Eur J Biochem250, 751-757. PubMed Europe PubMed
Mattei,M.G., Roeckel,N., Olsen,B.R. and Apte,S.S.
Genes of the membrane-type matrix metalloproteinase (MT- MMP) gene family, MMP14, MMP15, and MMP16, localize to human chromosomes 14, 16, and 8, respectively
Genomics40, 168-169. PubMed Europe PubMed DOI
Ohuchi,E., Imai,K., Fujii,Y., Sato,H., Seiki,M. and Okada,Y.
Membrane type 1 matrix metalloproteinase digests interstitial collagens and other extracellular matrix macromolecules
J Biol Chem272, 2446-2451. PubMed Europe PubMed DOI P
Okada,A., Tomasetto,C., Lutz,Y., Bellocq,J.P., Rio,M.C. and Basset,P.
Expression of matrix metalloproteinases during rat skin wound healing: evidence that membrane type-1 matrix metalloproteinase is a stromal activator of pro-gelatinase A
J Cell Biol137, 67-77. PubMed Europe PubMed DOI
Okumura,Y., Sato,H., Seiki,M. and Kido,H.
Proteolytic activation of the precursor of membrane type 1 matrix metalloproteinase by human plasmin. A possible cell surface activator
FEBS Lett402, 181-184. PubMed Europe PubMed DOI
Sato,H., Tanaka,M., Takino,T., Inoue,M. and Seiki,M.
Assignment of the human genes for membrane-type-1, -2, and -3 matrix metalloproteinases (MMP14, MMP15, and MMP16) to 14q12.2, 16q12.2-q21, and 8q21, respectively, by in situ hybridization
Genomics39, 412-413. PubMed Europe PubMed DOI
Ueno,H., Nakamura,H., Inoue,M., Imai,K., Noguchi,M., Sato,H., Seiki,M. and Okada,Y.
Expression and tissue localization of membrane-types 1, 2, and 3 matrix metalloproteinases in human invasive breast carcinomas
Cancer Res57, 2055-2060. PubMed Europe PubMed

1996

Fishman,D.A., Bafetti,L.M. and Stack,M.S.
Membrane-type matrix metalloproteinase expression and matrix metalloproteinase-2 activation in primary human ovarian epithelial carcinoma cells
Invasion Metastasis16, 150-159. PubMed Europe PubMed
Kinoh,H., Sato,H., Tsunezuka,Y., Takino,T., Kawashima,A., Okada,Y. and Seiki,M.
MT-MMP, the cell surface activator of proMMP-2 (pro-gelatinase A), is expressed with its substrate in mouse tissue during embryogenesis
J Cell Sci109, 953-959. PubMed Europe PubMed
Knauper,V., Will,H., Lopez-Otin,C., Smith,B., Atkinson,S.J., Stanton,H., Hembry,R.M. and Murphy,G.
Cellular mechanisms for human procollagenase-3 (MMP-13) activation. Evidence that MT1-MMP (MMP-14) and gelatinase A (MMP-2) are able to generate active enzyme
J Biol Chem271, 17124-17131. PubMed Europe PubMed DOI
Pei,D. and Weiss,S.J.
Transmembrane-deletion mutants of the membrane-type matrix metalloproteinase-1 process progelatinase A and express intrinsic matrix-degrading activity
J Biol Chem271, 9135-9140. PubMed Europe PubMed
[YEAR:9-9-1996]Sato,H., Kinoshita,T., Takino,T., Nakayama,K. and Seiki,M.
Activation of a recombinant membrane type 1-matrix metalloproteinase (MT1-MMP) by furin and its interaction with tissue inhibitor of metalloproteinases (TIMP)-2
FEBS Lett393, 101-104. PubMed Europe PubMed DOI
Sato,H. and Seiki,M.
Membrane-type matrix metalloproteinases (MT-MMPs) in tumor metastasis
J Biochem119, 209-215. PubMed Europe PubMed
Will,H., Atkinson,S.J., Butler,G.S., Smith,B. and Murphy,G.
The soluble catalytic domain of membrane type 1 matrix metalloproteinase cleaves the propeptide of progelatinase A and initiates autoproteolytic activation. Regulation by TIMP-2 and TIMP-3
J Biol Chem271, 17119-17123. PubMed Europe PubMed DOI

1995

[YEAR:18-5-1995]Pei,D. and Weiss,S.J.
Furin-dependent intracellular activation of the human stromelysin-3 zymogen
Nature375, 244-247. PubMed Europe PubMed DOI

1994

Sato,H., Takino,T., Okada,Y., Cao,J., Shinagawa,A., Yamamoto,E. and Seiki,M.
A matrix metalloproteinase expressed on the surface of invasive tumour cells
Nature370, 61-65. PubMed Europe PubMed DOI

1993

Brown,P.D., Bloxidge,R.E., Anderson,E. and Howell,A.
Expression of activated gelatinase in human invasive breast carcinoma
Clin Exp Metastasis11, 183-189. PubMed Europe PubMed
Brown,P.D., Bloxidge,R.E., Stuart,N.S., Gatter,K.C. and Carmichael,J.
Association between expression of activated 72-kilodalton gelatinase and tumor spread in non-small-cell lung carcinoma
J Natl Cancer Inst85, 574-578. PubMed Europe PubMed