Literature for peptidase M10.014: membrane-type matrix metallopeptidase-1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, I Inhibitor, L Localization, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

2025

Constanty,F., Wu,B., Wei,K.H., Lin,I.T., Dallmann,J., Guenther,S., Lautenschlaeger,T., Priya,R., Lai,S.L., Stainier,D.Y.R. and Beisaw,A. Border-zone cardiomyocytes and macrophages regulate extracellular matrix remodeling to promote cardiomyocyte protrusion during cardiac regeneration Nat Commun (2025) 16, 3823-3823. PubMed Europe PubMed DOI PMC EPMC
Lee,H., Hwang,Y., Mulder,E.J., Song,Y., Choi,C., Rong,L., Azar,D.T. and Han,K.Y. Selective Degradation and Inhibition of SARS-CoV-2 3CL(pro) by MMP14 Reveals a Novel Strategy for COVID-19 Therapeutics Int J Mol Sci (2025) 26 PubMed Europe PubMed DOI PMC EPMC
Muraoka,S., Brodie,W.D., Mattichak,M.N., Gurrea-Rubio,M., Ikari,Y., Foster,C., Amin,M.A., Khanna,N., Amin,H., Campbell,P.L., Vichaikul,S., Model,E.N., Omara,M.M., Petrovski,S., Kozicki,K., Amarista,C., Webber,A., Ali,M., Palisoc,P.J., Hervoso,J., Ruth,J.H., Tsoi,L.C., Varga,J., Gudjonsson,J.E., Khanna,D., Fox,D.A. and Tsou,P.S. Targeting CD13/aminopeptidase N as a novel therapeutic approach for scleroderma fibrosis Arthritis Rheumatol (2025) 77, 80-91. PubMed Europe PubMed DOI
Olson,A.W., Li,J., Li,X.Y., King,L., Banerjee,K., McCoy,A.J., Gondal,M.N., Chinnaiyan,A.M., El-Ashry,D., Keller,E.T., Putnam,A.J. and Weiss,S.J. Amoeboid-Mesenchymal Transition and the Proteolytic Control of Cancer Invasion Plasticity bioRxiv (2025) PubMed Europe PubMed DOI PMC EPMC
Takatsuka,R., Terashima,M., Ishimura,A., Suzuki,T. and Takino,T. Iron regulates MT1-MMP-mediated proMMP-2 activation and cancer cell invasion Biochem Biophys Res Commun (2025) 742, 151124-151124. PubMed Europe PubMed DOI
Wang,X., Lu,J., He,Y., Shu,Q., Lin,Y., Su,W. and Wang,P. MMP14 as a central mediator of TGF-beta1-induced extracellular matrix remodeling in graves' orbitopathy Front Endocrinol (Lausanne) (2025) 16, 1623842-1623842. PubMed Europe PubMed DOI PMC EPMC

2024

Asthana,P. and Wong,H.L.X. Preventing obesity, insulin resistance and type 2 diabetes by targeting MT1-MMP Biochim Biophys Acta Mol Basis Dis (2024) 1870, 167081-167081. PubMed Europe PubMed DOI
Ndoj,K., Meurs,A., Papaioannou,D., Bjune,K. and Zelcer,N. The low-density lipoprotein receptor: Emerging post-transcriptional regulatory mechanisms Atherosclerosis (2024) 401, 119082-119082. PubMed Europe PubMed DOI V
Sabeh,F., Li,X.Y., Olson,A.W., Botvinick,E., Kurup,A., Gimenez,L.E., Cho,J.S. and Weiss,S.J. Mmp14-dependent remodeling of the pericellular-dermal collagen interface governs fibroblast survival J Cell Biol (2024) 223 PubMed Europe PubMed DOI PMC EPMC
Wenzel,E.M., Pedersen,N.M., Elfmark,L.A., Wang,L., Kjos,I., Stang,E., Malerod,L., Brech,A., Stenmark,H. and Raiborg,C. Intercellular transfer of cancer cell invasiveness via endosome-mediated protease shedding Nat Commun (2024) 15, 1277-1277. PubMed Europe PubMed DOI PMC EPMC
Wichaiyo,S., Koonyosying,P. and Morales,N.P. Functional Roles of Furin in Cardio-Cerebrovascular Diseases ACS Pharmacol Transl Sci (2024) 7, 570-585. PubMed Europe PubMed DOI PMC EPMC V

2023

Bakiri,L. Open Thy Lattice Osteoclast, Resorb me! J Cell Biol (2023) 222 PubMed Europe PubMed DOI PMC EPMC
Bonadio,A., Wenig,B.L., Hockla,A., Radisky,E.S. and Shifman,J.M. Designed Loop Extension Followed by Combinatorial Screening Confers High Specificity to a Broad Matrix MetalloproteinaseInhibitor J Mol Biol (2023) 435, 168095-168095. PubMed Europe PubMed DOI PMC EPMC
Choe,H., Antee,T. and Ge,X. Substrate derived sequences act as subsite-blocking motifs in protease inhibitory antibodies Protein Sci (2023) 32, e4691-e4691. PubMed Europe PubMed DOI PMC EPMC
Chu,T.L., Chen,P., Yu,A.X., Kong,M., Tan,Z., Tsang,K.Y., Zhou,Z. and Cheah,K.S.E. MMP14 cleaves PTH1R in the chondrocyte-derived osteoblast lineage, curbing signaling intensity for proper bone anabolism elife (2023) 12 PubMed Europe PubMed DOI PMC EPMC
Da Silva,J., Freitas,J.R., do Carmo,E.R. and Gomes,J.R. MT1-MMP and TIMP-2 are first expressed in the colon glands after a single dose of azoxymethane (AOM) Anat Rec (Hoboken) (2023) PubMed Europe PubMed DOI
Hayun,H., Coban,M., Bhagat,A.K., Ozer,E., Alfonta,L., Caulfield,T.R., Radisky,E.S. and Papo,N. Utilizing genetic code expansion to modify N-TIMP2 specificity towards MMP-2, MMP-9, and MMP-14 Res Sq (2023) PubMed Europe PubMed DOI PMC EPMC
Hayun,H., Coban,M., Bhagat,A.K., Ozer,E., Alfonta,L., Caulfield,T.R., Radisky,E.S. and Papo,N. Utilizing genetic code expansion to modify N-TIMP2 specificity towards MMP-2, MMP-9, and MMP-14 Sci Rep (2023) 13, 5186-5186. PubMed Europe PubMed DOI PMC EPMC
Ikeda,K., Kaneko,R., Tsukamoto,E., Funahashi,N. and Koshikawa,N. Proteolytic cleavage of membrane proteins by membrane type-1 MMP regulates cancer malignant progression Cancer Sci (2023) 114, 348-356. PubMed Europe PubMed DOI PMC EPMC V
Lee,H., Youn,I., Demissie,R., Vaid,T.M., Che,C.T., Azar,D.T. and Han,K.Y. Identification of small molecule inhibitors against MMP-14 via High-Throughput screening Bioorg Med Chem (2023) 85, 117289-117289. PubMed Europe PubMed DOI PMC EPMC I
Samah,N., Ugusman,A., Hamid,A.A., Sulaiman,N. and Aminuddin,A. Role of Matrix Metalloproteinase-2 in the Development of Atherosclerosis among Patients with Coronary Artery Disease Mediators Inflamm (2023) 2023, 9715114-9715114. PubMed Europe PubMed DOI PMC EPMC V
Strouhalova,K., Tolde,O., Rosel,D. and Brabek,J. Cytoplasmic Tail of MT1-MMP: A Hub of MT1-MMP Regulation and Function Int J Mol Sci (2023) 24 PubMed Europe PubMed DOI PMC EPMC V
Su,H., Shu,S., Tang,W., Zheng,C., Zhao,L. and Fan,H. ETV4 facilitates angiogenesis in hepatocellular carcinoma by upregulating MMP14 expression Biochem Biophys Res Commun (2023) 684, 149137-149137. PubMed Europe PubMed DOI K
Tanaka,N. and Sakamoto,T. MT1-MMP as a Key Regulator of Metastasis Cells (2023) 12 PubMed Europe PubMed DOI PMC EPMC

2022

Fogarasi,M. and Dima,S. The Catalytic Domain Mediates Homomultimerization of MT1-MMP and the Prodomain Interferes with MT1-MMP Oligomeric Complex Assembly Biomolecules (2022) 12 PubMed Europe PubMed DOI PMC EPMC
Guo,X., Asthana,P., Gurung,S., Zhang,S., Wong,S.K.K., Fallah,S., Chow,C.F.W., Che,S., Zhai,L., Wang,Z., Ge,X., Jiang,Z., Wu,J., Zhang,Y., Wu,X., Xu,K., Lin,C.Y., Kwan,H.Y., Lyu,A., Zhou,Z., Bian,Z.X. and Wong,H.L.X. Regulation of age-associated insulin resistance by MT1-MMP-mediated cleavage of insulin receptor Nat Commun (2022) 13, 3749-3749. PubMed Europe PubMed DOI PMC EPMC
Hao,Q.G., Sun,F.G., Yan,C.H. and Sun,J.W. Progress on the role and mechanism of MT1-MMP in tumor metastasis Yi Chuan (2022) 44, 745-755. PubMed Europe PubMed DOI V
Kumper,M., Zamek,J., Steinkamp,J., Pach,E., Mauch,C. and Zigrino,P. Role of MMP3 and fibroblast-MMP14 in skin homeostasis and repair Eur J Cell Biol (2022) 101, 151276-151276. PubMed Europe PubMed DOI
Maybee,D.V., Ink,N.L. and Ali,M.A.M. Novel Roles of MT1-MMP and MMP-2: Beyond the Extracellular Milieu Int J Mol Sci (2022) 23 PubMed Europe PubMed DOI PMC EPMC V
Samulenas,G., Insodaite,R., Kunceviciene,E., Poceviciute,R., Masionyte,L., Zitkeviciute,U., Pilipaityte,L. and Smalinskiene,A. The Role of Functional Polymorphisms in the Extracellular Matrix Modulation-Related Genes on Dupuytren's Contracture Genes (Basel) (2022) 13 PubMed Europe PubMed DOI PMC EPMC
Werny,L., Grogro,A., Bickenbach,K., Bulck,C., Armbrust,F., Koudelka,T., Pathak,K., Scharfenberg,F., Sammel,M., Sheikhouny,F., Tholey,A., Linder,S. and Becker-Pauly,C. MT1-MMP and ADAM10/17 exhibit a remarkable overlap of shedding properties FEBS J (2022) 290, 93-111. PubMed Europe PubMed DOI

2021

Alabi,A., Xia,X.D., Gu,H.M., Wang,F., Deng,S.J., Yang,N., Adijiang,A., Douglas,D.N., Kneteman,N.M., Xue,Y., Chen,L., Qin,S., Wang,G. and Zhang,D.W. Membrane type 1 matrix metalloproteinase promotes LDL receptor shedding and accelerates the development of atherosclerosis Nat Commun (2021) 12, 1889-1889. PubMed Europe PubMed DOI PMC EPMC K
Bassiouni,W., Ali,M.A.M. and Schulz,R. Multifunctional intracellular matrix metalloproteinases: implications in disease FEBS J (2021) 288, 7162-7182. PubMed Europe PubMed DOI V
Butler,S.S., Date,K., Okumura,T., Lueck,C., Ghosh,B., Maitra,A. and Suh,J. Membrane-bound MMP-14 protease-activatable adeno-associated viral vectors for gene delivery to pancreatic tumors Gene Ther (2021) PubMed Europe PubMed DOI
Kumper,M., Hessenthaler,S., Zamek,J., Niland,S., Pach,E., Mauch,C. and Zigrino,P. Loss of Endothelial Cell Matrix Metalloproteinase 14 Reduces Melanoma Growth and Metastasis by Increasing Tumor Vessel Stability J Invest Dermatol (2021) PubMed Europe PubMed DOI
Pach,E., Kumper,M., Fromme,J.E., Zamek,J., Metzen,F., Koch,M., Mauch,C. and Zigrino,P. Extracellular Matrix Remodeling by Fibroblast-MMP14 Regulates Melanoma Growth Int J Mol Sci (2021) 22 PubMed Europe PubMed DOI PMC EPMC
Wang,X., Meng,Q., Wang,Y. and Gao,Y. Overexpression of MMP14 predicts the poor prognosis in gastric cancer: Meta-analysis and database validation Medicine (Baltimore) (2021) 100, e26545-e26545. PubMed Europe PubMed DOI PMC EPMC
Yamahana,H., Terashima,M., Takatsuka,R., Asada,C., Suzuki,T., Uto,Y. and Takino,T. Erratum: TGF-beta1 facilitates MT1-MMP-mediated proMMP-9 activation and invasion in oral squamous cell carcinoma cells (BBREP_101072) Biochem Biophys Rep (2021) 27, 101093-101093. PubMed Europe PubMed DOI PMC EPMC

2020

Attur,M., Lu,C., Zhang,X., Han,T., Alexandre,C., Valacca,C., Zheng,S., Meikle,S., Dabovic,B.B., Tassone,E., Yang,Q., Kolupaeva,V., Yakar,S., Abramson,S. and Mignatti,P. Membrane-type 1 Matrix Metalloproteinase Modulates Tissue Homeostasis by a Non-proteolytic Mechanism iScience (2020) 23, 101789-101789. PubMed Europe PubMed DOI PMC EPMC
Azevedo Martins,J.M., Rabelo-Santos,S.H., do Amaral Westin,M.C. and Zeferino,L.C. Tumoral and stromal expression of MMP-2, MMP-9, MMP-14, TIMP-1, TIMP-2, and VEGF-A in cervical cancer patient survival: a competing risk analysis BMC Cancer (2020) 20, 660-660. PubMed Europe PubMed DOI PMC EPMC
Carreca,A.P., Pravata,V.M., Markham,M., Bonelli,S., Murphy,G., Nagase,H., Troeberg,L. and Scilabra,S.D. TIMP-3 facilitates binding of target metalloproteinases to the endocytic receptor LRP-1 and promotes scavenging of MMP-1 Sci Rep (2020) 10, 12067-12067. PubMed Europe PubMed DOI PMC EPMC
Chen,N., Zhang,G., Fu,J. and Wu,Q. Matrix metalloproteinase-14 (MMP-14) downregulation inhibits esophageal squamous cell carcinoma cell migration, invasion, and proliferation Thorac Cancer (2020) 11, 3168-3174. PubMed Europe PubMed DOI K
Hu,Z., Gu,H., Ni,J., Hu,S., Hu,J., Wang,X., Liu,X. and Liu,X. Matrix metalloproteinase-14 regulates collagen degradation and migration of mononuclear cells during infection with genotype VII Newcastle disease virus J Gen Virol (2020) PubMed Europe PubMed DOI
Ingvarsen,S.Z., Gardsvoll,H., van Putten,S., Norregaard,K.S., Krigslund,O., Meilstrup,J.A., Tran,C., Jurgensen,H.J., Melander,M.C., Nielsen,C.H., Kjaer,A., Bugge,T.H., Engelholm,L.H. and Behrendt,N. Tumor cell MT1-MMP is dispensable for osteosarcoma tumor growth, bone degradation and lung metastasis Sci Rep (2020) 10, 19138-19138. PubMed Europe PubMed DOI PMC EPMC
Jiang,Z., Zhou,J., Qin,X., Zheng,H., Gao,B., Liu,X.G., Jin,G. and Zhou,Z. MT1-MMP deficiency leads to defective ependymal cell maturation, impaired ciliogenesis and hydrocephalus JCI Insight (2020) PubMed Europe PubMed DOI K
Ke,J.Y., Yang,J., Li,J., Xu,Z., Li,M.Q. and Zhu,Z.L. Baicalein inhibits FURIN-MT1-MMP-mediated invasion of ectopic endometrial stromal cells in endometriosis possibly by reducing the secretion of TGFB1 Am J Reprod Immunol (2020) , e13344-e13344. PubMed Europe PubMed DOI
Llorente,P., Martins,S., Sastre,I., Aldudo,J., Recuero,M., Adjaye,J. and Bullido,M.J. Matrix Metalloproteinase 14 Mediates APP Proteolysis and Lysosomal Alterations Induced by Oxidative Stress in Human Neuronal Cells Oxid Med Cell Longev (2020) 2020, 5917187-5917187. PubMed Europe PubMed DOI PMC EPMC
Matsuzaki,T., Keene,D.R., Nishimoto,E. and Noda,M. Reversion-inducing cysteine-rich protein with Kazal motifs and MT1-MMP promote the formation of robust fibrillin fibers J Cell Physiol (2020) PubMed Europe PubMed DOI
Nam,D.H., Lee,K.B., Kruchowy,E., Pham,H. and Ge,X. Protease Inhibition Mechanism of Camelid-like Synthetic Human Antibodies Biochemistry (2020) 59, 3802-3812. PubMed Europe PubMed DOI PMC EPMC
Oentaryo,M.J., Tse,A.C. and Lee,C.W. Neuronal MT1-MMP mediates ECM clearance and Lrp4 cleavage for agrin deposition and signaling in presynaptic development J Cell Sci (2020) 133 PubMed Europe PubMed DOI K
Suarez,H., Lopez-Martin,S., Toribio,V., Zamai,M., Hernandez-Riquer,M.V., Genis,L., Arroyo,A.G. and Yanez-Mo,M. Regulation of MT1-MMP activity through its association with ERMs Cells (2020) 9 PubMed Europe PubMed DOI
Zhang,Z., Bartsch,J.W., Benzel,J., Lei,T., Nimsky,C. and Voellger,B. Selective estrogen receptor modulators decrease invasiveness in pituitary adenoma cell lines AtT-20 and TtT/GF by affecting expression of MMP-14 and ADAM12 FEBS Open Bio (2020) 10, 2489-2498. PubMed Europe PubMed DOI

2019

Cuffaro,D., Nuti,E., Gifford,V., Ito,N., Camodeca,C., Tuccinardi,T., Nencetti,S., Orlandini,E., Itoh,Y. and Rossello,A. Design, synthesis and biological evaluation of bifunctional inhibitors of membrane type 1 matrix metalloproteinase (MT1-MMP) Bioorg Med Chem (2019) 27, 196-207. PubMed Europe PubMed DOI I
D'Amico,G., Munoz-Felix,J.M., Pedrosa,A.R. and Hodivala-Dilke,K.M. "Splitting the matrix": intussusceptive angiogenesis meets MT1-MMP EMBO Mol Med (2019) , e11663-e11663. PubMed Europe PubMed DOI
Jiang,B., Liu,J. and Lee,M.H. Targeting a designer TIMP-1 to the cell surface for effective MT1-MMP inhibition: a potential role for the prion protein in renal carcinoma therapy Molecules (2019) 24 PubMed Europe PubMed DOI
Knapinska,A.M. and Fields,G.B. The expanding role of MT1-MMP in cancer progression Pharmaceuticals (Basel) (2019) 12 PubMed Europe PubMed DOI V
Lee,K.B., Dunn,Z. and Ge,X. Reducing proteolytic liability of a MMP-14 inhibitory antibody by site-saturation mutagenesis Protein Sci (2019) 28, 643-653. PubMed Europe PubMed DOI
Li,X., Ma,Z., Wang,H., Ren,L., Zhang,D., Liang,W., Zhang,G., Zhang,J., Yu,D. and Fang,X. Screening, identification, and characterization of an affinity peptide specific to MT1-MMP and its application in tumor imaging Bioconjug Chem (2019) 30, 1507-1517. PubMed Europe PubMed DOI L
Ma,F., Zhu,Y., Chen,Y., Liu,J. and Zeng,X. Labeled and non-label electrochemical peptide inhibitor-based biosensing platform for determination of hemopexin domain of matrix metalloproteinase-14 Talanta (2019) 194, 548-553. PubMed Europe PubMed DOI A
Ma,F., Yan,J., Sun,L. and Chen,Y. Electrochemical impedance spectroscopy for quantization of matrix metalloproteinase-14 based on peptides inhibiting its homodimerization and heterodimerization Talanta (2019) 205, 120142-120142. PubMed Europe PubMed DOI A
Miekus,N., Luise,C., Sippl,W., Baczek,T., Schmelzer,C.E.H. and Heinz,A. MMP-14 degrades tropoelastin and elastin Biochimie (2019) 165, 32-39. PubMed Europe PubMed DOI P
Pietraszek-Gremplewicz,K., Karamanou,K., Niang,A., Dauchez,M., Belloy,N., Maquart,F.X., Baud,S. and Brezillon,S. Small leucine-rich proteoglycans and matrix metalloproteinase-14: key partners? Matrix Biol (2019) 75-76, 271-285. PubMed Europe PubMed DOI
Qi,Y., Wang,J., Sun,M., Ma,C., Jin,T., Liu,Y., Cao,Y. and Wang,J. MMP-14 single-nucleotide polymorphisms are related to steroid-induced osteonecrosis of the femoral head in the population of northern China Mol Genet Genomic Med (2019) 7, e00519-e00519. PubMed Europe PubMed DOI M
Yip,C., Foidart,P., Noel,A. and Sounni,N.E. MT4-MMP: the GPI-anchored membrane-type matrix metalloprotease with multiple functions in diseases Int J Mol Sci (2019) 20 PubMed Europe PubMed DOI

2018

Akhtar,N. Hijacking a morphogenesis proteinase for cancer cell invasion Dev Cell (2018) 47, 135-137. PubMed Europe PubMed DOI
Amara,N., Tholen,M. and Bogyo,M. Chemical tools for selective activity profiling of endogenously expressed MMP-14 in multicellular models ACS Chem Biol (2018) 13, 2645-2654. PubMed Europe PubMed DOI
Chen,K.E., Chen,C., Lopez,T., Radecki,K.C., Bustamante,K., Lorenson,M.Y., Ge,X. and Walker,A.M. Use of a novel camelid-inspired human antibody demonstrates the importance of MMP-14 to cancer stem cell function in the metastatic process Oncotarget (2018) 9, 29431-29444. PubMed Europe PubMed DOI PMC EPMC
Kikuchi,K., Kozuka-Hata,H., Oyama,M., Seiki,M. and Koshikawa,N. Identification of proteolytic cleavage sites of EphA2 by membrane type 1 matrix metalloproteinase on the surface of cancer cells Methods Mol Biol (2018) 1731, 29-37. PubMed Europe PubMed DOI P
Li,N., Zhang,W., Lin,L., He,Z., Khan,M. and Lin,J.M. Live imaging of cell membrane-localized MT1-MMP activity on a microfluidic chip Chem Commun (Camb) (2018) 54, 11435-11438. PubMed Europe PubMed DOI L
Liu,M., Qi,Y., Zhao,L., Chen,D., Zhou,Y., Zhou,H., Lv,Y., Zhang,L., Jin,S., Li,S., Zou,H., Jia,W., Wang,C., Jiang,J., Liang,W., Pang,L. and Li,F. Matrix metalloproteinase-14 induces epithelial-to-mesenchymal transition in synovial sarcoma Hum Pathol (2018) 80, 201-209. PubMed Europe PubMed DOI
Lopez,T., Chuan,C., Ramirez,A., Chen,K.E., Lorenson,M.Y., Benitez,C., Mustafa,Z., Pham,H., Sanchez,R., Walker,A.M. and Ge,X. Epitope-specific affinity maturation improved stability of potent protease inhibitory antibodies Biotechnol Bioeng (2018) 115, 2673-2682. PubMed Europe PubMed DOI
Nam,D.H. and Ge,X. Generation of highly selective MMP antibody inhibitors Methods Mol Biol (2018) 1731, 307-324. PubMed Europe PubMed DOI
Sakr,M., Li,X.Y., Sabeh,F., Feinberg,T.Y., Tesmer,J.J.G., Tang,Y. and Weiss,S.J. Tracking the Cartoon mouse phenotype: hemopexin domain-dependent regulation of MT1-MMP pericellular collagenolytic activity J Biol Chem (2018) 293, 8113-8127. PubMed Europe PubMed DOI M
Shirian,J., Arkadash,V., Cohen,I., Sapir,T., Radisky,E.S., Papo,N. and Shifman,J.M. Converting a broad matrix metalloproteinase family inhibitor into a specific inhibitor of MMP-9 and MMP-14 FEBS Lett (2018) 592, 1122-1134. PubMed Europe PubMed DOI
Takahashi,Y., Hamasaki,M., Aoki,M., Koga,K., Koshikawa,N., Miyamoto,S. and Nabeshima,K. Activated EphA2 processing by MT1-MMP is involved in malignant transformation of ovarian tumours in vivo Anticancer Res (2018) 38, 4257-4266. PubMed Europe PubMed DOI

2017

Almalki,S.G., Llamas Valle,Y. and Agrawal,D.K. MMP-2 and MMP-14 silencing inhibits VEGFR2 cleavage and induces the differentiation of porcine adipose-derived mesenchymal stem cells to endothelial cells Stem Cells Transl Med (2017) 6, 1385-1398. PubMed Europe PubMed DOI K
Arkadash,V., Yosef,G., Shirian,J., Cohen,I., Horev,Y., Grossman,M., Sagi,I., Radisky,E.S., Shifman,J.M. and Papo,N. Development of high affinity and high specificity inhibitors of matrix metalloproteinase 14 through computational design and directed evolution J Biol Chem (2017) 292, 3481-3495. PubMed Europe PubMed DOI
Butler,G.S., Connor,A.R., Sounni,N.E., Eckhard,U., Morrison,C.J., Noel,A. and Overall,C.M. Degradomic and yeast 2-hybrid inactive catalytic domain substrate trapping identifies new membrane-type 1 matrix metalloproteinase (MMP14) substrates: CCN3 (Nov) and CCN5 (WISP2) Matrix Biol (2017) 59, 23-38. PubMed Europe PubMed DOI P
Cepeda,M.A., Evered,C.L., Pelling,J.J.H. and Damjanovski,S. Inhibition of MT1-MMP proteolytic function and ERK1/2 signalling influences cell migration and invasion through changes in MMP-2 and MMP-9 levels J Cell Commun Signal (2017) 11, 167-179. PubMed Europe PubMed DOI
Decaneto,E., Lubitz,W. and Ogata,H. Structural studies of matrix metalloproteinase by X-ray diffraction Methods Mol Biol (2017) 1579, 49-60. PubMed Europe PubMed DOI E S
Decaneto,E., Vasilevskaya,T., Kutin,Y., Ogata,H., Grossman,M., Sagi,I., Havenith,M., Lubitz,W., Thiel,W. and Cox,N. Solvent water interactions within the active site of the membrane type I matrix metalloproteinase Phys Chem Chem Phys (2017) 19, 30316-30331. PubMed Europe PubMed DOI
Hong,S., Remacle,A.G., Shiryaev,S.A., Choi,W., Hullugundi,S.K., Dolkas,J., Angert,M., Nishihara,T., Yaksh,T.L., Strongin,A.Y. and Shubayev,V.I. Reciprocal relationship between membrane type 1 matrix metalloproteinase and the algesic peptides of myelin basic protein contributes to chronic neuropathic pain Brain Behav Immun (2017) 60, 282-292. PubMed Europe PubMed DOI
Jiang,B., Zhang,Y., Liu,J., Tsigkou,A., Rapti,M. and Lee,M.H. Ensnaring membrane type 1-matrix metalloproteinase (MT1-MMP) with tissue inhibitor of metalloproteinase (TIMP)-2 using the haemopexin domain of the protease as a carrier: a targeted approach in cancer inhibition Oncotarget (2017) 8, 22685-22699. PubMed Europe PubMed DOI
Ling,B., Watt,K., Banerjee,S., Newsted,D., Truesdell,P., Adams,J., Sidhu,S.S. and Craig,A.W. A novel immunotherapy targeting MMP-14 limits hypoxia, immune suppression and metastasis in triple-negative breast cancer models Oncotarget (2017) 8, 58372-58385. DOI
Lopez,T., Nam,D.H., Kaihara,E., Mustafa,Z. and Ge,X. Identification of highly selective MMP-14 inhibitory Fabs by deep sequencing Biotechnol Bioeng (2017) 114, 1140-1150. PubMed Europe PubMed DOI
Majkowska,I., Shitomi,Y., Ito,N., Gray,N.S. and Itoh,Y. Discoidin domain receptor 2 mediates collagen-induced activation of membrane-type 1 matrix metalloproteinase in human fibroblasts J Biol Chem (2017) 292, 6633-6643. PubMed Europe PubMed DOI
Nam,D.H., Fang,K., Rodriguez,C., Lopez,T. and Ge,X. Generation of inhibitory monoclonal antibodies targeting matrix metalloproteinase-14 by motif grafting and CDR optimization Protein Eng Des Sel (2017) 30, 113-118. PubMed Europe PubMed DOI
Stawowczyk,M., Wellenstein,M.D., Lee,S.B., Yomtoubian,S., Durrans,A., Choi,H., Narula,N., Altorki,N.K., Gao,D. and Mittal,V. Matrix metalloproteinase 14 promotes lung cancer by cleavage of heparin-binding EGF-like growth factor Neoplasia (2017) 19, 55-64. PubMed Europe PubMed DOI
Yamamoto,K., Santamaria,S., Botkjaer,K.A., Dudhia,J., Troeberg,L., Itoh,Y., Murphy,G. and Nagase,H. Inhibition of shedding of low-density lipoprotein receptor-related protein 1 reverses cartilage matrix degradation in osteoarthritis Arthritis Rheumatol (2017) 69, 1246-1256. PubMed Europe PubMed DOI

2016

Botkjaer,K.A., Kwok,H.F., Terp,M.G., Karatt-Vellatt,A., Santamaria,S., McCafferty,J., Andreasen,P.A., Itoh,Y., Ditzel,H.J. and Murphy,G. Development of a specific affinity-matured exosite inhibitor to MT1-MMP that efficiently inhibits tumor cell invasion in vitro and metastasis in vivo Oncotarget (2016) 7, 16773-16792. PubMed Europe PubMed DOI
Castro-Castro,A., Marchesin,V., Monteiro,P., Lodillinsky,C., Rosse,C. and Chavrier,P. Cellular and molecular mechanisms of MT1-MMP-dependent cancer cell invasion Annu Rev Cell Dev Biol (2016) 32, 555-576. PubMed Europe PubMed DOI
de Lucas,A.G., Schuhmacher,A.J., Oteo,M., Romero,E., Camara,J.A., de Martino,A., Arroyo,A.G., Morcillo,M.A., Squatrito,M., Martinez-Torrecuadrada,J.L. and Mulero,F. Targeting MT1-MMP as an ImmunoPET-based strategy for imaging gliomas PLoS ONE (2016) 11, e0158634-e0158634. PubMed Europe PubMed DOI L
El Azzouzi,K., Wiesner,C. and Linder,S. Metalloproteinase MT1-MMP islets act as memory devices for podosome reemergence J Cell Biol (2016) 213, 109-125. PubMed Europe PubMed DOI PMC EPMC
Fan,L., Liu,L., Zhu,C., Zhu,Q., Lu,S. and Liu,P. MT1-MMP inhibits the activity of Bst-2 via their cytoplasmic domains dependent interaction Int J Mol Sci (2016) 17 PubMed Europe PubMed DOI
Gucciardo,E., Mobashir,M. and Lehti,K. Proactive for invasion: reuse of matrix metalloproteinase for structural memory J Cell Biol (2016) 213, 11-13. PubMed Europe PubMed DOI PMC EPMC
Kaneko,K., Williams,R.O., Dransfield,D.T., Nixon,A.E., Sandison,A. and Itoh,Y. Selective inhibition of membrane type 1 matrix metalloproteinase abrogates progression of experimental inflammatory arthritis: synergy with tumor necrosis factor blockade Arthritis Rheumatol (2016) 68, 521-531. PubMed Europe PubMed DOI
Ku,M., Hong,Y., Heo,D., Lee,E., Hwang,S., Suh,J.S. and Yang,J. In vivo sensing of proteolytic activity with an NSET-based NIR fluorogenic nanosensor Biosens Bioelectron (2016) 77, 471-477. PubMed Europe PubMed DOI L
Mendes,D.E., Wong-On-Wing,A. and Berkman,C.E. Phosphoramidate-based peptidomimetic inhibitors of membrane type-1 matrix metalloproteinase J Enzyme Inhib Med Chem (2016) 31, 167-171. PubMed Europe PubMed DOI I
Nam,D.H. and Ge,X. Direct production of functional matrix metalloproteinase-14 without refolding or activation and its application for in vitro inhibition assays Biotechnol Bioeng (2016) 113, 717-723. PubMed Europe PubMed DOI E
Nam,D.H., Rodriguez,C., Remacle,A.G., Strongin,A.Y. and Ge,X. Active-site MMP-selective antibody inhibitors discovered from convex paratope synthetic libraries Proc Natl Acad Sci U S A (2016) 113, 14970-14975. PubMed Europe PubMed DOI
Nguyen,M.D. and Kang,K.A. MMP-14 triggered fluorescence contrast agent Adv Exp Med Biol (2016) 923, 413-419. PubMed Europe PubMed DOI A
Tatsukawa,R., Koga,K., Aoki,M., Koshikawa,N., Imafuku,S., Nakayama,J. and Nabeshima,K. Immunohistochemical demonstration of EphA2 processing by MT1-MMP in invasive cutaneous squamous cell carcinoma Virchows Arch (2016) 469, 25-34. PubMed Europe PubMed DOI
Thakur,V. and Bedogni,B. The membrane tethered matrix metalloproteinase MT1-MMP at the forefront of melanoma cell invasion and metastasis Pharmacol Res (2016) 111, 17-22. PubMed Europe PubMed DOI
Wong,H.L., Jin,G., Cao,R., Zhang,S., Cao,Y. and Zhou,Z. MT1-MMP sheds LYVE-1 on lymphatic endothelial cells and suppresses VEGF-C production to inhibit lymphangiogenesis Nat Commun (2016) 7, 10824-10824. PubMed Europe PubMed DOI PMC EPMC

2015

Bhowmick,M., Stawikowska,R., Tokmina-Roszyk,D. and Fields,G.B. Matrix metalloproteinase inhibition by heterotrimeric triple-helical peptide transition state analogues Chembiochem (2015) 16, 1084-1092. PubMed Europe PubMed DOI I
Chung,E.Y., Ochs,C.J., Wang,Y., Lei,L., Qin,Q., Smith,A.M., Strongin,A.Y., Kamm,R., Qi,Y.X., Lu,S. and Wang,Y. Activatable and cell-penetrable multiplex FRET nanosensor for profiling MT1-MMP activity in single cancer cells Nano Lett (2015) 15, 5025-5032. PubMed Europe PubMed DOI L
Decaneto,E., Suladze,S., Rosin,C., Havenith,M., Lubitz,W. and Winter,R. Pressure and temperature effects on the activity and structure of the catalytic domain of human MT1-MMP Biophys J (2015) 109, 2371-2381. PubMed Europe PubMed DOI
Gutierrez-Fernandez,A., Soria-Valles,C., Osorio,F.G., Gutierrez-Abril,J., Garabaya,C., Aguirre,A., Fueyo,A., Fernandez-Garcia,M.S., Puente,X.S. and Lopez-Otin,C. Loss of MT1-MMP causes cell senescence and nuclear defects which can be reversed by retinoic acid EMBO J (2015) 34, 1875-1888. PubMed Europe PubMed DOI
Nuti,E., Cantelmo,A.R., Gallo,C., Bruno,A., Bassani,B., Camodeca,C., Tuccinardi,T., Vera,L., Orlandini,E., Nencetti,S., Stura,E.A., Martinelli,A., Dive,V., Albini,A. and Rossello,A. N-O-Isopropyl sulfonamido-based hydroxamates as matrix metalloproteinase inhibitors: hit selection and in vivo antiangiogenic activity J Med Chem (2015) 58, 7224-7240. PubMed Europe PubMed DOI I
Overland,A.C. and Insel,P.A. Heterotrimeric G proteins directly regulate MMP14/membrane type-1 matrix metalloprotease: a novel mechanism for GPCR-EGFR transactivation J Biol Chem (2015) 290, 9941-9947. PubMed Europe PubMed DOI
Shaverdashvili,K., Zhang,K., Osman,I., Honda,K., Jobava,R. and Bedogni,B. MT1-MMP dependent repression of the tumor suppressor SPRY4 contributes to MT1-MMP driven melanoma cell motility Oncotarget (2015) 6, 33512-33522. PubMed Europe PubMed DOI
Snyman,C. and Niesler,C.U. MMP-14 in skeletal muscle repair J Muscle Res Cell Motil (2015) 36, 215-225. PubMed Europe PubMed DOI
Tassone,E., Valacca,C. and Mignatti,P. Membrane-type 1 matrix metalloproteinase downregulates fibroblast growth factor-2 binding to the cell surface and intracellular signaling J Cell Physiol (2015) 230, 366-377. PubMed Europe PubMed DOI
Taylor,S.H., Yeung,C.Y., Kalson,N.S., Lu,Y., Zigrino,P., Starborg,T., Warwood,S., Holmes,D.F., Canty-Laird,E.G., Mauch,C. and Kadler,K.E. Matrix metalloproteinase 14 is required for fibrous tissue expansion elife (2015) 4, e09345-e09345. PubMed Europe PubMed DOI
Terawaki,S., Kitano,K., Aoyama,M., Mori,T. and Hakoshima,T. MT1-MMP recognition by ERM proteins and its implication in CD44 shedding Genes Cells (2015) 20, 847-859. PubMed Europe PubMed DOI S
Udi,Y., Grossman,M., Solomonov,I., Dym,O., Rozenberg,H., Moreno,V., Cuniasse,P., Dive,V., Arroyo,A.G. and Sagi,I. Inhibition mechanism of membrane metalloprotease by an exosite-swiveling conformational antibody Structure (2015) 23, 104-115. PubMed Europe PubMed DOI
Ulasov,I., Borovjagin,A.V., Kaverina,N., Schroeder,B., Shah,N., Lin,B., Baryshnikov,A. and Cobbs,C. MT1-MMP silencing by an shRNA-armed glioma-targeted conditionally replicative adenovirus (CRAd) improves its anti-glioma efficacy in vitro and in vivo Cancer Lett (2015) 365, 240-250. PubMed Europe PubMed DOI K
Wang,Y., Lu,H., Yu,D., Zhang,J., Liang,W., Zhang,Z. and Fang,X. Potent selective inhibition of MMP-14 by chloroauric acid and its inhibitory effect on cancer cell invasion RSC Adv (2015) 5, 17700-17708. DOI I
Zeng,L., Tan,B., Yang,Y., Qiu,J., Xiong,L. and Mao,C. [Virtual screening and molecular simulations of antisense peptides targeting MT1-MMP] Sheng Wu Gong Cheng Xue Bao (2015) 31, 269-280. PubMed Europe PubMed DOI I
Zhao,Y., Marcink,T.C., Sanganna Gari,R.R., Marsh,B.P., King,G.M., Stawikowska,R., Fields,G.B. and Van Doren,S.R. Transient collagen triple helix binding to a key metalloproteinase in invasion and development Structure (2015) 23, 257-269. PubMed Europe PubMed DOI PMC EPMC

2014

Buache,E., Thai,R., Wendling,C., Alpy,F., Page,A., Chenard,M.P., Dive,V., Ruff,M., Dejaegere,A., Tomasetto,C. and Rio,M.C. Functional relationship between matrix metalloproteinase-11 and matrix metalloproteinase-14 Cancer Med (2014) 3, 1197-1210. PubMed Europe PubMed DOI
Gaublomme,D., Buyens,T., De Groef,L., Stakenborg,M., Janssens,E., Ingvarsen,S., Porse,A., Behrendt,N. and Moons,L. Matrix metalloproteinase 2 and membrane type 1 matrix metalloproteinase co-regulate axonal outgrowth of mouse retinal ganglion cells J Neurochem (2014) 129, 966-979. PubMed Europe PubMed DOI
Hong,Y., Ku,M., Heo,D., Hwang,S., Lee,E., Park,J., Choi,J., Jung Lee,H., Seo,M., Jig Lee,E., In Yook,J., Haam,S., Huh,Y.M., Sung Yoon,D., Suh,J.S. and Yang,J. Molecular recognition of proteolytic activity in metastatic cancer cells using fluorogenic gold nanoprobes Biosens Bioelectron (2014) 57, 171-178. PubMed Europe PubMed DOI L
Ma,J., Tang,X., Wong,P., Jacobs,B., Borden,E.C. and Bedogni,B. Noncanonical activation of Notch1 protein by membrane type 1 matrix metalloproteinase (MT1-MMP) controls melanoma cell proliferation J Biol Chem (2014) 289, 8442-8449. PubMed Europe PubMed DOI
Ogata,H., Decaneto,E., Grossman,M., Havenith,M., Sagi,I., Lubitz,W. and Knipp,M. Crystallization and preliminary X-ray crystallographic analysis of the catalytic domain of membrane type 1 matrix metalloproteinase Acta Crystallogr F Struct Biol Commun (2014) 70, 232-235. PubMed Europe PubMed DOI
Ouyang,M., Lu,S. and Wang,Y. Genetically encoded fluorescent biosensors for live-cell imaging of MT1-MMP protease activity Methods Mol Biol (2014) 1071, 163-174. PubMed Europe PubMed DOI L
Pietraszek,K., Chatron-Colliet,A., Brezillon,S., Perreau,C., Jakubiak-Augustyn,A., Krotkiewski,H., Maquart,F.X. and Wegrowski,Y. Lumican: a new inhibitor of matrix metalloproteinase-14 activity FEBS Lett (2014) 588, 4319-4324. PubMed Europe PubMed DOI
Tobar,N., Avalos,M.C., Mendez,N., Smith,P.C., Bernabeu,C., Quintanilla,M. and Martinez,J. Soluble MMP-14 produced by bone marrow-derived stromal cells sheds epithelial endoglin modulating the migratory properties of human breast cancer cells Carcinogenesis (2014) 35, 1770-1779. PubMed Europe PubMed DOI
Wali,N., Hosokawa,K., Malik,S., Saito,H., Miyaguchi,K., Imajoh-Ohmi,S., Miki,Y. and Nakanishi,A. Centrosomal BRCA2 is a target protein of membrane type-1 matrix metalloproteinase (MT1-MMP) Biochem Biophys Res Commun (2014) 443, 1148-1154. PubMed Europe PubMed DOI P

2013

Alcantara,M.B. and Dass,C.R. Regulation of MT1-MMP and MMP-2 by the serpin PEDF: a promising new target for metastatic cancer Cell Physiol Biochem (2013) 31, 487-494. PubMed Europe PubMed DOI
Hiden,U., Ghaffari-Tabrizi,N., Gauster,M., Tam-Amersdorfer,C., Cetin,I., Dieber-Rotheneder,M., Lang,U. and Desoye,G. Membrane-type matrix metalloproteinase 1 regulates trophoblast functions and is reduced in fetal growth restriction Am J Pathol (2013) 182, 1563-1571. PubMed Europe PubMed DOI
Ingvarsen,S., Porse,A., Erpicum,C., Maertens,L., Jurgensen,H.J., Madsen,D.H., Melander,M.C., Gardsvoll,H., Hoyer-Hansen,G., Noel,A., Holmbeck,K., Engelholm,L.H. and Behrendt,N. Targeting a single function of the multifunctional matrix metalloprotease MT1-MMP: impact on lymphangiogenesis J Biol Chem (2013) 288, 10195-10204. PubMed Europe PubMed DOI
Janssens,E., Gaublomme,D., De Groef,L., Darras,V.M., Arckens,L., Delorme,N., Claes,F., Van Hove,I. and Moons,L. Matrix metalloproteinase 14 in the zebrafish: an eye on retinal and retinotectal development PLoS ONE (2013) 8, e52915-e52915. PubMed Europe PubMed DOI PMC EPMC
Kaimal,R., Aljumaily,R., Tressel,S.L., Pradhan,R.V., Covic,L., Kuliopulos,A., Zarwan,C., Kim,Y.B., Sharifi,S. and Agarwal,A. Selective blockade of matrix metalloprotease-14 with a monoclonal antibody abrogates invasion, angiogenesis, and tumor growth in ovarian cancer Cancer Res (2013) 73, 2457-2467. PubMed Europe PubMed DOI
Keely,P.J. Proteolytic remodeling of the ECM and the geometric control of stem cell fate Dev Cell (2013) 25, 325-326. PubMed Europe PubMed DOI
Lee,H., Chang,K.W., Yang,H.Y., Lin,P.W., Chen,S.U. and Huang,Y.L. MT1-MMP regulates MMP-2 expression and angiogenesis-related functions in human umbilical vein endothelial cells Biochem Biophys Res Commun (2013) 437, 232-238. PubMed Europe PubMed DOI
Manon-Jensen,T., Multhaupt,H.A. and Couchman,J.R. Mapping of matrix metalloproteinase cleavage sites on syndecan-1 and syndecan-4 ectodomains FEBS J (2013) 280, 2320-2331. PubMed Europe PubMed DOI P
Marques,S.M., Abate,C.C., Chaves,S., Marques,F., Santos,I., Nuti,E., Rossello,A. and Santos,M.A. New bifunctional metalloproteinase inhibitors: an integrated approach towards biological improvements and cancer therapy J Inorg Biochem (2013) 127, 188-202. PubMed Europe PubMed DOI I
Remacle,A.G., Shiryaev,S.A., Golubkov,V.S., Freskos,J.N., Brown,M.A., Karwa,A.S., Naik,A.D., Howard,C.P., Sympson,C.J. and Strongin,A.Y. Non-destructive and selective imaging of the functionally active, pro-invasive membrane type-1 matrix metalloproteinase (MT1-MMP) enzyme in cancer cells J Biol Chem (2013) 288, 20568-20580. PubMed Europe PubMed DOI L
Schroder,H.M., Hoffmann,S.C., Hecker,M., Korff,T. and Ludwig,T. The tetraspanin network modulates MT1-MMP cell surface trafficking Int J Biochem Cell Biol (2013) 45, 1133-1144. PubMed Europe PubMed DOI
Stegemann,C., Didangelos,A., Barallobre-Barreiro,J., Langley,S.R., Mandal,K., Jahangiri,M. and Mayr,M. Proteomic identification of matrix metalloproteinase substrates in the human vasculature Circ Cardiovasc Genet (2013) 6, 106-117. PubMed Europe PubMed DOI P
Sugiyama,N., Gucciardo,E., Tatti,O., Varjosalo,M., Hyytiainen,M., Gstaiger,M. and Lehti,K. EphA2 cleavage by MT1-MMP triggers single cancer cell invasion via homotypic cell repulsion J Cell Biol (2013) 201, 467-484. PubMed Europe PubMed DOI PMC EPMC
Takahashi,T., Fujimori,C., Hagiwara,A. and Ogiwara,K. Recent advances in the understanding of teleost medaka ovulation: the roles of proteases and prostaglandins Zoolog Sci (2013) 30, 239-247. PubMed Europe PubMed DOI
Woskowicz,A.M., Weaver,S.A., Shitomi,Y., Ito,N. and Itoh,Y. MT-LOOP-dependent localization of membrane type I matrix metalloproteinase (MT1-MMP) to the cell adhesion complexes promotes cancer cell invasion J Biol Chem (2013) 288, 35126-35137. PubMed Europe PubMed DOI

2012

Basu,B., Correa de Sampaio,P., Mohammed,H., Fogarasi,M., Corrie,P., Watkins,N.A., Smethurst,P.A., English,W.R., Ouwehand,W.H. and Murphy,G. Inhibition of MT1-MMP activity using functional antibody fragments selected against its hemopexin domain Int J Biochem Cell Biol (2012) 44, 393-403. PubMed Europe PubMed DOI
Chan,K.M., Wong,H.L., Jin,G., Liu,B., Cao,R., Cao,Y., Lehti,K., Tryggvason,K. and Zhou,Z. MT1-MMP inactivates ADAM9 to regulate FGFR2 signaling and calvarial osteogenesis Dev Cell (2012) 22, 1176-1190. PubMed Europe PubMed DOI
Cork,S.M., Kaur,B., Devi,N.S., Cooper,L., Saltz,J.H., Sandberg,E.M., Kaluz,S. and Van Meir,E.G. A proprotein convertase/MMP-14 proteolytic cascade releases a novel 40kDa vasculostatin from tumor suppressor BAI1 Oncogene (2012) 31, 5144-5152. PubMed Europe PubMed DOI
Domoto,T., Takino,T., Guo,L. and Sato,H. Cleavage of hepatocyte growth factor activator inhibitor-1 by membrane-type MMP-1 activates matriptase Cancer Sci (2012) 103, 448-454. PubMed Europe PubMed DOI
Eisenach,P.A., de Sampaio,P.C., Murphy,G. and Roghi,C. Membrane type 1 matrix metalloproteinase (MT1-MMP) ubiquitination at Lys581 increases cellular invasion through type I collagen J Biol Chem (2012) 287, 11533-11545. PubMed Europe PubMed DOI
Evans,B.R., Mosig,R.A., Lobl,M., Martignetti,C.R., Camacho,C., Grum-Tokars,V., Glucksman,M.J. and Martignetti,J.A. Mutation of membrane type-1 metalloproteinase, MT1-MMP, causes the multicentric osteolysis and arthritis disease Winchester syndrome Am J Hum Genet (2012) 91, 572-576. PubMed Europe PubMed DOI M
Guo,L., Takino,T., Endo,Y., Domoto,T. and Sato,H. Shedding of kidney injury molecule-1 by membrane-type 1 matrix metalloproteinase J Biochem (2012) 152, 425-432. PubMed Europe PubMed DOI
Itoh,Y. and Seiki,M. Membrane-type matrix metalloproteinase 1 [ISSN:978-0-12-407744-7] (2012) 3, 804-814. DOI
Koziol,A., Gonzalo,P., Mota,A., Pollan,A., Lorenzo,C., Colome,N., Montaner,D., Dopazo,J., Arribas,J., Canals,F. and Arroyo,A.G. The protease MT1-MMP drives a combinatorial proteolytic program in activated endothelial cells FASEB J (2012) 26, 4481-4494. PubMed Europe PubMed DOI
Kulkarni,R.N., Bakker,A.D., Gruber,E.V., Chae,T.D., Veldkamp,J.B., Klein-Nulend,J. and Everts,V. MT1-MMP modulates the mechanosensitivity of osteocytes Biochem Biophys Res Commun (2012) 417, 824-829. PubMed Europe PubMed DOI
Lee,G., Eom,K., Park,J., Yang,J., Haam,S., Huh,Y.M., Ryu,J.K., Kim,N.H., Yook,J.I., Lee,S.W., Yoon,D.S. and Kwon,T. Real-time quantitative monitoring of specific peptide cleavage by a proteinase for cancer diagnosis Angew Chem Int Ed Engl (2012) 51, 5837-5841. PubMed Europe PubMed DOI A
Malinowski,M., Pietraszek,K., Perreau,C., Boguslawski,M., Decot,V., Stoltz,J.F., Vallar,L., Niewiarowska,J., Cierniewski,C., Maquart,F.X., Wegrowski,Y. and Brezillon,S. Effect of lumican on the migration of human mesenchymal stem cells and endothelial progenitor cells: involvement of matrix metalloproteinase-14 PLoS ONE (2012) 7, e50709-e50709. PubMed Europe PubMed DOI PMC EPMC
Patel,T.R., Butler,G., McFarlane,A., Xie,I., Overall,C.M. and Stetefeld,J. Site specific cleavage mediated by MMPs regulates function of agrin PLoS ONE (2012) 7, e43669-e43669. PubMed Europe PubMed DOI PMC EPMC P
Remacle,A.G., Golubkov,V.S., Shiryaev,S.A., Dahl,R., Stebbins,J.L., Chernov,A.V., Cheltsov,A.V., Pellecchia,M. and Strongin,A.Y. Novel MT1-MMP small-molecule inhibitors based on insights into hemopexin domain function in tumor growth Cancer Res (2012) 72, 2339-2349. PubMed Europe PubMed DOI I
Weng,C.J., Chen,M.K., Lin,C.W., Chung,T.T. and Yang,S.F. Single nucleotide polymorphisms and haplotypes of MMP-14 are associated with the risk and pathological development of oral cancer Ann Surg Oncol (2012) 19 Suppl 3, S319-S327. PubMed Europe PubMed DOI M
Zigrino,P., Ayachi,O., Schild,A., Kaltenberg,J., Zamek,J., Nischt,R., Koch,M. and Mauch,C. Loss of epidermal MMP-14 expression interferes with angiogenesis but not with re-epithelialization Eur J Cell Biol (2012) 91, 748-756. PubMed Europe PubMed DOI K

2011

Ando,K., Ishibashi,T., Ohkawara,H., Inoue,N., Sugimoto,K., Uekita,H., Hu,C., Okamoto,Y., Takuwa,Y. and Takeishi,Y. Crucial role of membrane type 1 matrix metalloproteinase (MT1- MMP) in RhoA/Rac1-dependent signaling pathways in thrombin- stimulated endothelial cells J Atheroscler Thromb (2011) 18, 762-773. PubMed Europe PubMed DOI
Choi,S.S., Ji,A.R., Yu,S.W., Cho,B.H., Park,J.D., Park,J.H., Lee,H.S., Ryu,S.E., Kim,D.H., Kang,J.H. and Lee,S.T. Inhibition of invasion and capillary-like tube formation by retrohydroxamate-based MMP inhibitors Bull Korean Chem Soc (2011) 32, 2032-2038. DOI I
Frittoli,E., Palamidessi,A., Disanza,A. and Scita,G. Secretory and endo/exocytic trafficking in invadopodia formation: the MT1-MMP paradigm Eur J Cell Biol (2011) 90, 108-114. PubMed Europe PubMed DOI
Galiacy,S.D., Fournie,P., Massoudi,D., Ancele,E., Quintyn,J.C., Erraud,A., Raymond-Letron,I., Rolling,F. and Malecaze,F. Matrix metalloproteinase 14 overexpression reduces corneal scarring Gene Ther (2011) 18, 462-468. PubMed Europe PubMed DOI U
Golubkov,V.S., Chernov,A.V. and Strongin,A.Y. Intradomain cleavage of inhibitory prodomain is essential to protumorigenic function of membrane type-1 matrix metalloproteinase (MT1-MMP) in vivo J Biol Chem (2011) 286, 34215-34223. PubMed Europe PubMed DOI
Grant Rowe,R., Keena,D., Sabeh,F., Willis,A.L. and Weiss,S.J. Pulmonary fibroblasts mobilize the membrane-tethered matrix metalloprotease, MT1-MMP, to destructively remodel and invade interstitial type I collagen barriers Am J Physiol Lung Cell Mol Physiol (2011) 301, L683-L692. PubMed Europe PubMed DOI
Grossman,M., Born,B., Heyden,M., Tworowski,D., Fields,G.B., Sagi,I. and Havenith,M. Correlated structural kinetics and retarded solvent dynamics at the metalloprotease active site Nat Struct Mol Biol (2011) 18, 1102-1108. PubMed Europe PubMed DOI
Hara,T., Mimura,K., Seiki,M. and Sakamoto,T. Genetic dissection of proteolytic and non-proteolytic contributions of MT1-MMP to macrophage invasion Biochem Biophys Res Commun (2011) 413, 277-281. PubMed Europe PubMed DOI
Itoh,Y., Palmisano,R., Anilkumar,N., Nagase,H., Miyawaki,A. and Seiki,M. Dimerization of MT1-MMP during cellular invasion detected by fluorescence resonance energy transfer Biochem J (2011) 440, 319-326. PubMed Europe PubMed DOI
Jabaiah,A. and Daugherty,P.S. Directed evolution of protease beacons that enable sensitive detection of endogenous MT1-MMP activity in tumor cell lines Chem Biol (2011) 18, 392-401. PubMed Europe PubMed DOI P
Jin,G., Zhang,F., Chan,K.M., Xavier Wong,H.L., Liu,B., Cheah,K.S., Liu,X., Mauch,C., Liu,D. and Zhou,Z. MT1-MMP cleaves Dll1 to negatively regulate Notch signalling to maintain normal B-cell development EMBO J (2011) 30, 2281-2293. PubMed Europe PubMed DOI I
Park,J.H., Park,S.M., Park,K.H., Cho,K.H. and Lee,S.T. Analysis of apolipoprotein A-I as a substrate for matrix metalloproteinase-14 Biochem Biophys Res Commun (2011) 409, 58-63. PubMed Europe PubMed DOI P
Robichaud,T.K., Steffensen,B. and Fields,G.B. Exosite interactions impact matrix metalloproteinase collagen specificities J Biol Chem (2011) 286, 37535-37542. PubMed Europe PubMed DOI P
Saygili,E., Schauerte,P., Pekassa,M., Saygili,E., Rackauskas,G., Schwinger,R.H.G., Weis,J., Weber,C., Marx,N. and Rana,O.R. Sympathetic neurons express and secrete MMP-2 and MT1-MMP to control nerve sprouting via pro-NGF conversion Cell Mol Neurobiol (2011) 31, 17-25. PubMed Europe PubMed DOI
Shi,F. and Sottile,J. MT1-MMP regulates the turnover and endocytosis of extracellular matrix fibronectin J Cell Sci (2011) 124, 4039-4050. PubMed Europe PubMed DOI
Sina,A., Lord-Dufour,S., Roy,R. and Annabi,B. Pharmacological targeting of MT1-MMP by actinonin in brain tumours Bio Trib Mag (2011) 38, 39-45. DOI I
Tochowicz,A., Goettig,P., Evans,R., Visse,R., Shitomi,Y., Palmisano,R., Ito,N., Richter,K., Maskos,K., Franke,D., Svergun,D., Nagase,H., Bode,W. and Itoh,Y. The dimer interface of the membrane type 1 matrix metalloproteinase hemopexin domain: crystal structure and biological functions J Biol Chem (2011) 286, 7587-7600. PubMed Europe PubMed DOI
Zarrabi,K., Dufour,A., Li,J., Kuscu,C., Pulkoski-Gross,A., Zhi,J., Hu,Y., Sampson,N.S., Zucker,S. and Cao,J. Inhibition of matrix metalloproteinase 14 (MMP-14)-mediated cancer cell migration J Biol Chem (2011) 286, 33167-33177. PubMed Europe PubMed DOI
Zhu,L., Wang,H., Wang,L., Wang,Y., Jiang,K., Li,C., Ma,Q., Gao,S., Wang,L., Li,W., Cai,M., Wang,H., Niu,G., Lee,S., Yang,W., Fang,X. and Chen,X. High-affinity peptide against MT1-MMP for in vivo tumor imaging J Control Release (2011) 150, 248-255. PubMed Europe PubMed DOI L

2010

De Croos,J.N., Roughley,P.J. and Kandel,R.A. Improved bioengineered cartilage tissue formation following cyclic compression is dependent on upregulation of MT1-MMP J Orthop Res (2010) 28, 921-927. PubMed Europe PubMed DOI
Gingras,D. and Beliveau,R. Emerging concepts in the regulation of membrane-type 1 matrix metalloproteinase activity Biochim Biophys Acta (2010) 1803, 142-150. PubMed Europe PubMed DOI
Gioia,M., Fasciglione,G.F., Monaco,S., Iundusi,R., Sbardella,D., Marini,S., Tarantino,U. and Coletta,M. pH dependence of the enzymatic processing of collagen I by MMP-1 (fibroblast collagenase), MMP-2 (gelatinase A), and MMP-14 ectodomain J Biol Inorg Chem (2010) 15, 1219-1232. PubMed Europe PubMed DOI
Golubkov,V.S., Cieplak,P., Chekanov,A.V., Ratnikov,B.I., Aleshin,A.E., Golubkova,N.V., Postnova,T.I., Radichev,I.A., Rozanov,D.V., Zhu,W., Motamedchaboki,K. and Strongin,A.Y. Internal cleavages of the autoinhibitory prodomain are required for membrane type 1 matrix metalloproteinase activation, although furin cleavage alone generates inactive proteinase J Biol Chem (2010) 285, 27726-27736. PubMed Europe PubMed DOI
Gulotta,L.V., Kovacevic,D., Montgomery,S., Ehteshami,J.R., Packer,J.D. and Rodeo,S.A. Stem cells genetically modified with the developmental gene MT1-MMP improve regeneration of the supraspinatus tendon-to-bone insertion site Am J Sports Med (2010) 38, 1429-1437. PubMed Europe PubMed DOI
Itoh,Y. Metalloproteinase binding proteins: WO2009097397 Expert Opin Ther Pat (2010) 20, 1091-1095. PubMed Europe PubMed DOI
Koshikawa,N., Mizushima,H., Minegishi,T., Iwamoto,R., Mekada,E. and Seiki,M. Membrane type 1-matrix metalloproteinase cleaves off the NH2-terminal portion of heparin-binding epidermal growth factor and converts it into a heparin-independent growth factor Cancer Res (2010) 70, 6093-6103. PubMed Europe PubMed DOI
Liu,G., Atteridge,C.L., Wang,X., Lundgren,A.D. and Wu,J.D. The membrane type matrix metalloproteinase MMP14 mediates constitutive shedding of MHC class I chain-related molecule A independent of a disintegrin and metalloproteinases J Immunol (2010) 184, 3346-3350. PubMed Europe PubMed DOI
Liu,P., Yang,J., Pei,J., Pei,D. and Wilson,M.J. Regulation of MT1-MMP activity by beta-catenin in MDCK non-cancer and HT1080 cancer cells J Cell Physiol (2010) 225, 810-821. PubMed Europe PubMed DOI
Nyalendo,C., Sartelet,H., Gingras,D. and Beliveau,R. Inhibition of membrane-type 1 matrix metalloproteinase tyrosine phosphorylation blocks tumor progression in mice Anticancer Res (2010) 30, 1887-1895. PubMed Europe PubMed
Riggins,K.S., Mernaugh,G., Su,Y., Quaranta,V., Koshikawa,N., Seiki,M., Pozzi,A. and Zent,R. MT1-MMP-mediated basement membrane remodeling modulates renal development Exp Cell Res (2010) 316, 2993-3005. PubMed Europe PubMed DOI
Roghi,C., Jones,L., Gratian,M., English,W.R. and Murphy,G. Golgi reassembly stacking protein 55 interacts with membrane-type (MT) 1-matrix metalloprotease (MMP) and furin and plays a role in the activation of the MT1-MMP zymogen FEBS J (2010) 277, 3158-3175. PubMed Europe PubMed DOI
Sato,H. and Takino,T. Coordinate action of membrane-type matrix metalloproteinase-1 (MT1-MMP) and MMP-2 enhances pericellular proteolysis and invasion Cancer Sci (2010) 101, 843-847. PubMed Europe PubMed DOI V
Strongin,A.Y. Proteolytic and non-proteolytic roles of membrane type-1 matrix metalloproteinase in malignancy Biochim Biophys Acta (2010) 1803, 133-141. PubMed Europe PubMed DOI

2009

Butler,G.S., Dean,R.A., Smith,D. and Overall,C.M. Membrane protease degradomics: proteomic identification and quantification of cell surface protease substrates Methods Mol Biol (2009) 528, 159-176. PubMed Europe PubMed DOI P
Deshmukh,H.S., McLachlan,A., Atkinson,J.J., Hardie,W.D., Korfhagen,T.R., Dietsch,M., Liu,Y., Di,P.Y., Wesselkamper,S.C., Borchers,M.T. and Leikauf,G.D. Matrix metalloproteinase-14 mediates a phenotypic shift in the airways to increase mucin production Am J Respir Crit Care Med (2009) 180, 834-845. PubMed Europe PubMed DOI PMC EPMC
Devy,L., Huang,L., Naa,L., Yanamandra,N., Pieters,H., Frans,N., Chang,E., Tao,Q., Vanhove,M., Lejeune,A., van Gool,R., Sexton,D.J., Kuang,G., Rank,D., Hogan,S., Pazmany,C., Ma,Y.L., Schoonbroodt,S., Nixon,A.E., Ladner,R.C., Hoet,R., Henderikx,P., Tenhoor,C., Rabbani,S.A., Valentino,M.L., Wood,C.R. and Dransfield,D.T. Selective inhibition of matrix metalloproteinase-14 blocks tumor growth, invasion, and angiogenesis Cancer Res (2009) 69, 1517-1526. PubMed Europe PubMed DOI
Gooyit,M., Lee,M., Hesek,D., Boggess,B., Oliver,A.G., Fridman,R., Mobashery,S. and Chang,M. Synthesis, kinetic characterization and metabolism of diastereomeric 2-(1-(4-phenoxyphenylsulfonyl)ethyl)thiiranes as potent gelatinase and MT1-MMP inhibitors Chem Biol Drug Des (2009) 74, 535-546. PubMed Europe PubMed DOI I
Guo,A., Yang,L. and Gu,J.C. Membrane type-1 metalloproteinase mediates nitric oxide-induced activation of matrix metalloproteinase-13 Orthopedics (2009) 32, 826-826. PubMed Europe PubMed DOI
Miller,M.C., Manning,H.B., Jain,A., Troeberg,L., Dudhia,J., Essex,D., Sandison,A., Seiki,M., Nanchahal,J., Nagase,H. and Itoh,Y. Membrane type 1 matrix metalloproteinase is a crucial promoter of synovial invasion in human rheumatoid arthritis Arthritis Rheum (2009) 60, 686-697. PubMed Europe PubMed DOI PMC EPMC
Moss,N.M., Wu,Y.I., Liu,Y., Munshi,H.G. and Stack,M.S. Modulation of the membrane type 1 matrix metalloproteinase cytoplasmic tail enhances tumor cell invasion and proliferation in three-dimensional collagen matrices J Biol Chem (2009) 284, 19791-19799. PubMed Europe PubMed DOI PMC EPMC
Niiya,D., Egawa,N., Sakamoto,T., Kikkawa,Y., Shinkawa,T., Isobe,T., Koshikawa,N. and Seiki,M. Identification and characterization of Lutheran blood group glycoprotein as a new substrate of membrane-type 1 matrix metalloproteinase 1 (MT1-MMP): a systemic whole cell analysis of MT1-MMP-associating proteins in A431 cells J Biol Chem (2009) 284, 27360-27369. PubMed Europe PubMed DOI PMC EPMC P
Poincloux,R., Lizarraga,F. and Chavrier,P. Matrix invasion by tumour cells: a focus on MT1-MMP trafficking to invadopodia J Cell Sci (2009) 122, 3015-3024. PubMed Europe PubMed DOI
Radichev,I.A., Remacle,A.G., Sounni,N.E., Shiryaev,S.A., Rozanov,D.V., Zhu,W., Golubkova,N.V., Postnova,T.I., Golubkov,V.S. and Strongin,A.Y. Biochemical evidence of the interactions of membrane type-1 matrix metalloproteinase (MT1-MMP) with adenine nucleotide translocator (ANT): potential implications linking proteolysis with energy metabolism in cancer cells Biochem J (2009) 420, 37-47. PubMed Europe PubMed DOI PMC EPMC
Sabeh,F., Li,X.Y., Saunders,T.L., Rowe,R.G. and Weiss,S.J. Secreted versus membrane-anchored collagenases: relative roles in fibroblast-dependent collagenolysis and invasion J Biol Chem (2009) 284, 23001-23011. PubMed Europe PubMed DOI PMC EPMC
Sabeh,F., Shimizu-Hirota,R. and Weiss,S.J. Protease-dependent versus -independent cancer cell invasion programs: three-dimensional amoeboid movement revisited J Cell Biol (2009) 185, 11-19. PubMed Europe PubMed DOI PMC EPMC
Sakamoto,T. and Seiki,M. Cytoplasmic tail of MT1-MMP regulates macrophage motility independently from its protease activity Genes Cells (2009) 14, 617-626. PubMed Europe PubMed DOI
Sina,A., Lord-Dufour,S. and Annabi,B. Cell-based evidence for aminopeptidase N/CD13 inhibitor actinonin targeting of MT1-MMP-mediated proMMP-2 activation Cancer Lett (2009) 279, 171-176. PubMed Europe PubMed DOI I
Suojanen,J., Salo,T., Koivunen,E., Sorsa,T. and Pirila,E. A novel and selective membrane type-1 matrix metalloproteinase (MT1-MMP) inhibitor reduces cancer cell motility and tumor growth Cancer Biol Ther (2009) 8, 2362-2370. PubMed Europe PubMed I
Wang,X., Wilson,M.J., Slaton,J.W., Sinha,A.A., Ewing,S.L. and Pei,D. Increased aggressiveness of human prostate PC-3 tumor cells expressing cell surface localized membrane type-1 matrix metalloproteinase (MT1-MMP) J Androl (2009) 30, 259-274. PubMed Europe PubMed DOI
Xiong,W., Knispel,R., MacTaggart,J., Greiner,T.C., Weiss,S.J. and Baxter,B.T. Membrane-type 1 matrix metalloproteinase regulates macrophage-dependent elastolytic activity and aneurysm formation in vivo J Biol Chem (2009) 284, 1765-1771. PubMed Europe PubMed DOI PMC EPMC

2008

Barbolina,M.V. and Stack,M.S. Membrane type 1-matrix metalloproteinase: substrate diversity in pericellular proteolysis Semin Cell Dev Biol (2008) 19, 24-33. PubMed Europe PubMed DOI PMC EPMC V
Cho,J.A., Osenkowski,P., Zhao,H., Kim,S., Toth,M., Cole,K., Aboukameel,A., Saliganan,A., Schuger,L., Bonfil,R.D. and Fridman,R. The inactive 44-kDa processed form of membrane type 1 matrix metalloproteinase (MT1-MMP) enhances proteolytic activity via regulation of endocytosis of active MT1-MMP J Biol Chem (2008) 283, 17391-17405. PubMed Europe PubMed DOI PMC EPMC
Coyle,R.C., Latimer,A. and Jessen,J.R. Membrane-type 1 matrix metalloproteinase regulates cell migration during zebrafish gastrulation: evidence for an interaction with non-canonical Wnt signaling Exp Cell Res (2008) 314, 2150-2162. PubMed Europe PubMed DOI K
D'Alessio,S., Ferrari,G., Cinnante,K., Scheerer,W., Galloway,A.C., Roses,D.F., Rozanov,D.V., Remacle,A.G., Oh,E.S., Shiryaev,S.A., Strongin,A.Y., Pintucci,G. and Mignatti,P. Tissue inhibitor of metalloproteinases-2 binding to membrane-type 1 matrix metalloproteinase induces MAPK activation and cell growth by a non-proteolytic mechanism J Biol Chem (2008) 283, 87-99. PubMed Europe PubMed DOI
Ingvarsen,S., Madsen,D.H., Hillig,T., Lund,L.R., Holmbeck,K., Behrendt,N. and Engelholm,L.H. Dimerization of endogenous MT1-MMP is a regulatory step in the activation of the 72-kDa gelatinase MMP-2 on fibroblasts and fibrosarcoma cells Biol Chem (2008) 389, 943-953. PubMed Europe PubMed DOI
Itoh,Y., Ito,N., Nagase,H. and Seiki,M. The second dimer interface of MT1-MMP, the transmembrane domain, is essential for proMMP-2 activation on the cell surface J Biol Chem (2008) 283, 13053-13062. PubMed Europe PubMed DOI PMC EPMC
Li,X.Y., Ota,I., Yana,I., Sabeh,F. and Weiss,S.J. Molecular dissection of the structural machinery underlying the tissue-invasive activity of membrane type-1 matrix metalloproteinase Mol Biol Cell (2008) 19, 3221-3233. PubMed Europe PubMed DOI PMC EPMC
Nishida,Y., Miyamori,H., Thompson,E.W., Takino,T., Endo,Y. and Sato,H. Activation of matrix metalloproteinase-2 (MMP-2) by membrane type 1 matrix metalloproteinase through an artificial receptor for proMMP-2 generates active MMP-2 Cancer Res (2008) 68, 9096-9104. PubMed Europe PubMed DOI
Park,J.H., Park,S.M., Park,S.H., Cho,K.H. and Lee,S.T. Cleavage and functional loss of human apolipoprotein E by digestion of matrix metalloproteinase-14 Proteomics (2008) 8, 2926-2935. PubMed Europe PubMed DOI
Schneider,F., Sukhova,G.K., Aikawa,M., Canner,J., Gerdes,N., Tang,S.M., Shi,G.P., Apte,S.S. and Libby,P. Matrix-metalloproteinase-14 deficiency in bone-marrow-derived cells promotes collagen accumulation in mouse atherosclerotic plaques Circulation (2008) 117, 931-939. PubMed Europe PubMed DOI
Shimokawa,H. Bone-marrow-derived matrix metalloproteinase-14: a novel target for plaque stability Circulation (2008) 117, 863-865. PubMed Europe PubMed DOI
Terawaki,S., Kitano,K., Aoyama,M. and Hakoshima,T. Crystallographic characterization of the radixin FERM domain bound to the cytoplasmic tail of membrane-type 1 matrix metalloproteinase (MT1-MMP) Acta Crystallograph Sect F Struct Biol Cryst Commun (2008) 64, 911-913. PubMed Europe PubMed DOI PMC EPMC

2007

Abd El-Aziz,S.H., Endo,Y., Miyamaori,H., Takino,T. and Sato,H. Cleavage of growth differentiation factor 15 (GDF15) by membrane type 1-matrix metalloproteinase abrogates GDF15-mediated suppression of tumor cell growth Cancer Sci (2007) 98, 1330-1335. PubMed Europe PubMed DOI
Arroyo,A.G., Genis,L., Gonzalo,P., Matias-Roman,S., Pollan,A. and Galvez,B.G. Matrix metalloproteinases: new routes to the use of MT1-MMP as a therapeutic target in angiogenesis-related disease Curr Pharm Des (2007) 13, 1787-1802. PubMed Europe PubMed DOI
Basile,J.R., Holmbeck,K., Bugge,T.H. and Gutkind,J.S. MT1-MMP controls tumor-induced angiogenesis through the release of semaphorin 4D J Biol Chem (2007) 282, 6899-6905. PubMed Europe PubMed DOI
Currie,J.C., Fortier,S., Sina,A., Galipeau,J., Cao,J. and Annabi,B. MT1-MMP down-regulates the glucose 6-phosphate transporter expression in marrow stromal cells: a molecular link between pro-MMP-2 activation, chemotaxis, and cell survival J Biol Chem (2007) 282, 8142-8149. PubMed Europe PubMed DOI
Gioia,M., Monaco,S., Fasciglione,G.F., Coletti,A., Modesti,A., Marini,S. and Coletta,M. Characterization of the mechanisms by which gelatinase A, neutrophil collagenase, and membrane-type metalloproteinase MMP-14 recognize collagen I and enzymatically process the two alpha-chains J Mol Biol (2007) 368, 1101-1113. PubMed Europe PubMed DOI
Golubkov,V.S., Chekanov,A.V., Shiryaev,S.A., Aleshin,A.E., Ratnikov,B.I., Gawlik,K., Radichev,I., Motamedchaboki,K., Smith,J.W. and Strongin,A.Y. Proteolysis of the membrane type-1 matrix metalloproteinase prodomain: implications for a two-step proteolytic processing and activation J Biol Chem (2007) 282, 36283-36291. PubMed Europe PubMed DOI
Hasebe,T., Hartman,R., Fu,L., Amano,T. and Shi,Y.B. Evidence for a cooperative role of gelatinase A and membrane type-1 matrix metalloproteinase during Xenopus laevis development Mech Dev (2007) 124, 11-22. PubMed Europe PubMed DOI PMC EPMC
Hu,N., Zhou,X.W., Fu,H.J., Xing,R.Y., Kong,W. and Zheng,X.F. Inhibitory effect of antisense RNA on the gene expression of membrane-type 1 matrix metalloproteinase and invasiveness of human gastric carcinoma cells World Chin J Dig (2007) 15, 1470-1474.
Lee,H., Sodek,K.L., Hwang,Q., Brown,T.J., Ringuette,M. and Sodek,J. Phagocytosis of collagen by fibroblasts and invasive cancer cells is mediated by MT1-MMP Biochem Soc Trans (2007) 35, 704-706. PubMed Europe PubMed DOI
Sodek,K.L., Ringuette,M.J. and Brown,T.J. MT1-MMP is the critical determinant of matrix degradation and invasion by ovarian cancer cells Br J Cancer (2007) 97, 358-367. PubMed Europe PubMed DOI PMC EPMC T
Taniwaki,K., Fukamachi,H., Komori,K., Ohtake,Y., Nonaka,T., Sakamoto,T., Shiomi,T., Okada,Y., Itoh,T., Itohara,S., Seiki,M. and Yana,I. Stroma-derived matrix metalloproteinase (MMP)-2 promotes membrane type 1-MMP-dependent tumor growth in mice Cancer Res (2007) 67, 4311-4319. PubMed Europe PubMed DOI
Wolf,K., Wu,Y.I., Liu,Y., Geiger,J., Tam,E., Overall,C., Stack,M.S. and Friedl,P. Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion Nat Cell Biol (2007) 9, 893-904. PubMed Europe PubMed DOI

2006

[YEAR:10-5-2006]Atkinson,S.J., Roghi,C. and Murphy,G. MT1-MMP hemopexin domain exchange with MT4-MMP blocks enzyme maturation and trafficking to the plasma membrane in MCF7 cells Biochem J (10-5-2006) 398, 15-22. PubMed Europe PubMed DOI PMC EPMC
Chun,T.H., Hotary,K.B., Sabeh,F., Saltiel,A.R., Allen,E.D. and Weiss,S.J. A pericellular collagenase directs the 3-dimensional development of white adipose tissue Cell (2006) 125, 577-591. PubMed Europe PubMed DOI
Egawa,N., Koshikawa,N., Tomari,T., Nabeshima,K., Isobe,T. and Seiki,M. Membrane type 1 matrix metalloproteinase (MT1-MMP/MMP-14) cleaves and releases a 22-kDa extracellular matrix metalloproteinase inducer (EMMPRIN) fragment from tumor cells J Biol Chem (2006) 281, 37576-37585. PubMed Europe PubMed DOI P
Genis,L., Galvez,B.G., Gonzalo,P. and Arroyo,A.G. MT1-MMP: universal or particular player in angiogenesis? Cancer Metastasis Rev (2006) 25, 77-86. PubMed Europe PubMed DOI V
[YEAR:1-11-2006]Golubkov,V.S., Chekanov,A.V., Savinov,A.Y., Rozanov,D.V., Golubkova,N.V. and Strongin,A.Y. Membrane type-1 matrix metalloproteinase confers aneuploidy and tumorigenicity on mammary epithelial cells Cancer Res (1-11-2006) 66, 10460-10465. PubMed Europe PubMed DOI
[YEAR:18-1-2006]Hasebe,T., Hartman,R., Matsuda,H. and Shi,Y.B. Spatial and temporal expression profiles suggest the involvement of gelatinase A and membrane type 1 matrix metalloproteinase in amphibian metamorphosis Cell Tissue Res (18-1-2006) 324, 105-116. PubMed Europe PubMed DOI
Hotary,K., Li,X.Y., Allen,E., Stevens,S.L. and Weiss,S.J. A cancer cell metalloprotease triad regulates the basement membrane transmigration program Genes Dev (2006) 20, 2673-2686. PubMed Europe PubMed DOI PMC EPMC
[YEAR:26-5-2006]Itoh,Y. and Seiki,M. MT1-MMP: a potent modifier of pericellular microenvironment J Cell Physiol (26-5-2006) 206, 1-8. PubMed Europe PubMed DOI V
Itoh,Y., Ito,N., Nagase,H., Evans,R.D., Bird,S.A. and Seiki,M. Cell surface collagenolysis requires homodimerization of the membrane-bound collagenase MT1-MMP Mol Biol Cell (2006) 17, 5390-5399. PubMed Europe PubMed DOI PMC EPMC
Itoh,Y. MT1-MMP: a key regulator of cell migration in tissue IUBMB Life (2006) 58, 589-596. PubMed Europe PubMed DOI
[YEAR:15-9-2006]Lee,H., Overall,C.M., McCulloch,C.A. and Sodek,J. A critical role for the membrane-type 1 matrix metalloproteinase in collagen phagocytosis Mol Biol Cell (15-9-2006) 17, 4812-4826. PubMed Europe PubMed DOI PMC EPMC
[YEAR:24-4-2006]Remacle,A.G., Rozanov,D.V., Fugere,M., Day,R. and Strongin,A.Y. Furin regulates the intracellular activation and the uptake rate of cell surface-associated MT1-MMP Oncogene (24-4-2006) 25, 5648-5655. PubMed Europe PubMed DOI
[YEAR:20-4-2006]Remacle,A.G., Chekanov,A.V., Golubkov,V.S., Savinov,A.Y., Rozanov,D.V. and Strongin,A.Y. O-glycosylation regulates autolysis of cellular membrane type-1 matrix metalloproteinase (MT1-MMP) J Biol Chem (20-4-2006) 281, 16897-16905. PubMed Europe PubMed DOI
[YEAR:22-9-2006]Toth,M., Sohail,A., Mobashery,S. and Fridman,R. MT1-MMP shedding involves an ADAM and is independent of its localization in lipid rafts Biochem Biophys Res Commun (22-9-2006) 350, 377-384. PubMed Europe PubMed DOI

2005

[YEAR:9-6-2005]Anilkumar,N., Uekita,T., Couchman,J.R., Nagase,H., Seiki,M. and Itoh,Y. Palmitoylation at Cys574 is essential for MT1-MMP to promote cell migration FASEB J (9-6-2005) 19, 1326-1328. PubMed Europe PubMed DOI
[YEAR:28-2-2005]Atkinson,J.J., Holmbeck,K., Yamada,S., Birkedal-Hansen,H., Parks,W.C. and Senior,R.M. Membrane-type 1 matrix metalloproteinase is required for normal alveolar development Dev Dyn (28-2-2005) 232, 1079-1090. PubMed Europe PubMed DOI K
Bair,E.L., Chen,M.L., McDaniel,K., Sekiguchi,K., Cress,A.E., Nagle,R.B. and Bowden,G.T. Membrane type 1 matrix metalloprotease cleaves laminin-10 and promotes prostate cancer cell migration Neoplasia (2005) 7, 380-389. PubMed Europe PubMed DOI PMC EPMC P
[YEAR:8-3-2005]Deschamps,A.M., Yarbrough,W.M., Squires,C.E., Allen,R.A., McClister,D.M., Dowdy,K.B., McLean,J.E., Mingoia,J.T., Sample,J.A., Mukherjee,R. and Spinale,F.G. Trafficking of the membrane type-1 matrix metalloproteinase in ischemia and reperfusion: relation to interstitial membrane type-1 matrix metalloproteinase activity Circulation (8-3-2005) 111, 1166-1174. PubMed Europe PubMed DOI
Filippov,S., Koenig,G.C., Chun,T.H., Hotary,K.B., Ota,I., Bugge,T.H., Roberts,J.D., Fay,W.P., Birkedal-Hansen,H., Holmbeck,K., Sabeh,F., Allen,E.D. and Weiss,S.J. MT1-matrix metalloproteinase directs arterial wall invasion and neointima formation by vascular smooth muscle cells J Exp Med (2005) 202, 663-671. PubMed Europe PubMed DOI PMC EPMC
[YEAR:4-5-2005]Golubkov,V.S., Boyd,S., Savinov,A.Y., Chekanov,A.V., Osterman,A.L., Remacle,A., Rozanov,D.V., Doxsey,S.J. and Strongin,A.Y. Membrane type-1 matrix metalloproteinase (MT1-MMP) exhibits an important intracellular cleavage function and causes chromosome instability J Biol Chem (4-5-2005) 280, 25079-25086. PubMed Europe PubMed DOI
Irie,K., Komori,K., Seiki,M., Tsuruga,E., Sakakura,Y., Kaku,T. and Yajima,T. Impaired alveolization in mice deficient in membrane-type matrix metalloproteinase 1 (MT1-MMP) Med Mol Morphol (2005) 38, 43-46. PubMed Europe PubMed DOI K
[YEAR:3-11-2005]Koshikawa,N., Minegishi,T., Sharabi,A., Quaranta,V. and Seiki,M. Membrane-type matrix metalloproteinase-1 (MT1-MMP) is a processing enzyme for human laminin gamma 2 chain J Biol Chem (3-11-2005) 280, 88-93. PubMed Europe PubMed DOI
Oblander,S.A., Zhou,Z., Galvez,B.G., Starcher,B., Shannon,J.M., Durbeej,M., Arroyo,A.G., Tryggvason,K. and Apte,S.S. Distinctive functions of membrane type 1 matrix-metalloprotease (MT1-MMP or MMP-14) in lung and submandibular gland development are independent of its role in pro-MMP-2 activation Dev Biol (2005) 277, 255-269. PubMed Europe PubMed DOI
[YEAR:10-11-2005]Page,L.J., Suk,J.Y., Huff,M.E., Lim,H.J., Venable,J., Yates,J., Kelly,J.W. and Balch,W.E. Metalloendoprotease cleavage triggers gelsolin amyloidogenesis EMBO J (10-11-2005) 24, 4124-4132. PubMed Europe PubMed DOI PMC EPMC
[YEAR:1-3-2005]Rossello,A., Nuti,E., Carelli,P., Orlandini,E., Macchia,M., Nencetti,S., Zandomeneghi,M., Balzano,F., Uccello Barretta,G., Albini,A., Benelli,R., Cercignani,G., Murphy,G. and Balsamo,A. N-i-Propoxy-N-biphenylsulfonylaminobutylhydroxamic acids as potent and selective inhibitors of MMP-2 and MT1-MMP Bioorg Med Chem Lett (1-3-2005) 15, 1321-1326. PubMed Europe PubMed DOI I
[YEAR:8-6-2005]Savinov,A.Y., Rozanov,D.V., Golubkov,V.S., Wong,F.S. and Strongin,A.Y. Inhibition of membrane type-1 matrix metalloproteinase by cancer drugs interferes with the homing of diabetogenic T cells into the pancreas J Biol Chem (8-6-2005) 280, 27755-27758. PubMed Europe PubMed DOI I
[YEAR:22-11-2005]Suenaga,N., Mori,H., Itoh,Y. and Seiki,M. CD44 binding through the hemopexin-like domain is critical for its shedding by membrane-type 1 matrix metalloproteinase Oncogene (22-11-2005) 24, 859-868. PubMed Europe PubMed DOI
[YEAR:24-11-2005]Toth,M., Osenkowski,P., Hesek,D., Brown,S., Meroueh,S., Sakr,W., Mobashery,S. and Fridman,R. Cleavage at the stem region releases an active ectodomain of the membrane type 1 matrix metalloproteinase Biochem J (24-11-2005) 387, 497-506. PubMed Europe PubMed DOI PMC EPMC
Wu,M., Shi,Y., Xi,L., Li,Q., Liao,G.N., Han,Z.Q., Lu,Y.P. and Ma,D. Construction of antisense MT1-MMP vector and its inhibitory effects on invasion of human ovarian cancer cells J Huazhong Univ Sci Technolog Med Sci (2005) 25, 715-717. PubMed Europe PubMed K

2004

[YEAR:2-4-2004]Cao,J., Kozarekar,P., Pavlaki,M., Chiarelli,C., Bahou,W.F. and Zucker,S. Distinct roles for the catalytic and hemopexin domains of membrane type 1-matrix metalloproteinase in substrate degradation and cell migration J Biol Chem (2-4-2004) 279, 14129-14139. PubMed Europe PubMed DOI
Holmbeck,K., Bianco,P., Yamada,S. and Birkedal-Hansen,H. MT1-MMP: a tethered collagenase J Cell Physiol (2004) 200, 11-19. PubMed Europe PubMed DOI K
[YEAR:1-2-2004]Hurst,D.R., Schwartz,M.A., Ghaffari,M.A., Jin,Y., Tschesche,H., Fields,G.B. and Sang,Q.X. Catalytic- and ecto-domains of membrane type 1-matrix metalloproteinase have similar inhibition profiles but distinct endopeptidase activities Biochem J (1-2-2004) 377, 775-779. PubMed Europe PubMed DOI PMC EPMC
[YEAR:1-10-2004]Hwang,I.K., Park,S.M., Kim,S.Y. and Lee,S.T. A proteomic approach to identify substrates of matrix metalloproteinase-14 in human plasma Biochim Biophys Acta (1-10-2004) 1702, 79-87. PubMed Europe PubMed DOI
Iida,J., Wilhelmson,K.L., Price,M.A., Wilson,C.M., Pei,D., Furcht,L.T. and McCarthy,J.B. Membrane type-1 matrix metalloproteinase promotes human melanoma invasion and growth J Invest Dermatol (2004) 122, 167-176. PubMed Europe PubMed DOI
Itoh,Y. and Seiki,M. Membrane-type matrix metalloproteinase 1 [ISSN:0-12-079610-4] (2004) 2, 544-549. V
Itoh,Y. and Seiki,M. MT1-MMP: an enzyme with multidimensional regulation Trends Biochem Sci (2004) 29, 285-289. PubMed Europe PubMed DOI
[YEAR:1-10-2004]Li,Y., Aoki,T., Mori,Y., Ahmad,M., Miyamori,H., Takino,T. and Sato,H. Cleavage of lumican by membrane-type matrix metalloproteinase-1 abrogates this proteoglycan-mediated suppression of tumor cell colony formation in soft agar Cancer Res (1-10-2004) 64, 7058-7064. PubMed Europe PubMed DOI
[YEAR:15-12-2004]Mazzone,M., Baldassarre,M., Beznoussenko,G., Giacchetti,G., Cao,J., Zucker,S., Luini,A. and Buccione,R. Intracellular processing and activation of membrane type 1 matrix metalloprotease depends on its partitioning into lipid domains J Cell Sci (15-12-2004) 117, 6275-6287. PubMed Europe PubMed DOI
[YEAR:14-9-2004]Minond,D., Lauer-Fields,J.L., Nagase,H. and Fields,G.B. Matrix metalloproteinase triple-helical peptidase activities are differentially regulated by substrate stability Biochemistry (14-9-2004) 43, 11474-11481. PubMed Europe PubMed DOI
Mirastschijski,U., Zhou,Z., Rollman,O., Tryggvason,K. and Agren,M.S. Wound healing in membrane-type-1 matrix metalloproteinase-deficient mice J Invest Dermatol (2004) 123, 600-602. PubMed Europe PubMed DOI
[YEAR:28-9-2004]Oak,M.H., El Bedoui,J., Anglard,P. and Schini-Kerth,V.B. Red wine polyphenolic compounds strongly inhibit pro-matrix metalloproteinase-2 expression and its activation in response to thrombin via direct inhibition of membrane type 1-matrix metalloproteinase in vascular smooth muscle cells Circulation (28-9-2004) 110, 1861-1867. PubMed Europe PubMed DOI
[YEAR:5-4-2004]Oh,J., Takahashi,R., Adachi,E., Kondo,S., Kuratomi,S., Noma,A., Alexander,D.B., Motoda,H., Okada,A., Seiki,M., Itoh,T., Itohara,S., Takahashi,C. and Noda,M. Mutations in two matrix metalloproteinase genes, MMP-2 and MT1-MMP, are synthetic lethal in mice Oncogene (5-4-2004) 23, 5041-5048. PubMed Europe PubMed DOI K
[YEAR:16-9-2004]Rozanov,D.V., Sikora,S., Godzik,A., Postnova,T.I., Golubkov,V., Savinov,A., Tomlinson,S. and Strongin,A.Y. Non-proteolytic, receptor/ligand interactions associate cellular membrane type-1 matrix metalloproteinase with the complement component C1q J Biol Chem (16-9-2004) 279, 50321-50328. PubMed Europe PubMed DOI
[YEAR:14-9-2004]Rozanov,D.V., Savinov,A.Y., Golubkov,V.S., Postnova,T.I., Remacle,A., Tomlinson,S. and Strongin,A.Y. Cellular membrane type-1 matrix metalloproteinase (MT1-MMP) cleaves C3b, an essential component of the complement system J Biol Chem (14-9-2004) 279, 46551-46557. PubMed Europe PubMed DOI
[YEAR:20-9-2004]Wang,P., Nie,J. and Pei,D. The hemopexin domain of membrane-type matrix metalloproteinase-1 (MT1-MMP) Is not required for its activation of proMMP2 on cell surface but is essential for MT1-MMP-mediated invasion in three-dimensional type I collagen J Biol Chem (20-9-2004) 279, 51148-51155. PubMed Europe PubMed DOI
[YEAR:11-12-2004]Wu,Y.I., Munshi,H.G., Sen,R., Snipas,S.J., Salvesen,G.S., Fridman,R. and Stack,M.S. Glycosylation broadens the substrate profile of membrane type 1 matrix metalloproteinase J Biol Chem (11-12-2004) 279, 8278-8289. PubMed Europe PubMed DOI
[YEAR:16-12-2004]Zhao,H., Bernardo,M.M., Osenkowski,P., Sohail,A., Pei,D., Nagase,H., Kashiwagi,M., Soloway,P.D., DeClerck,Y.A. and Fridman,R. Differential inhibition of membrane type 3 (MT3)-matrix metalloproteinase (MMP) and MT1-MMP by tissue inhibitor of metalloproteinase (TIMP)-2 and TIMP-3 rgulates pro-MMP-2 activation J Biol Chem (16-12-2004) 279, 8592-8601. PubMed Europe PubMed DOI I

2003

[YEAR:15-11-2003]Baciu,P.C., Suleiman,E.A., Deryugina,E.I. and Strongin,A.Y. Membrane type-1 matrix metalloproteinase (MT1-MMP) processing of pro-alphav integrin regulates cross-talk between alphavbeta3 and alpha2beta1 integrins in breast carcinoma cells Exp Cell Res (15-11-2003) 291, 167-175. PubMed Europe PubMed DOI
Bartlett,J.D., Zhou,Z., Skobe,Z., Dobeck,J.M. and Tryggvason,K. Delayed tooth eruption in membrane type-1 matrix metalloproteinase deficient mice Connect Tissue Res (2003) 44 Suppl 1, 300-304. PubMed Europe PubMed K
Beertsen,W., Holmbeck,K., Niehof,A., Bianco,P., Chrysovergis,K., Birkedal-Hansen,H. and Everts,V. Inhibition of molar eruption and root elongation in MT1-MMP-deficient mice Connect Tissue Res (2003) 44 Suppl 1, 298-299. PubMed Europe PubMed K
[YEAR:17-10-2003]Endo,K., Takino,T., Miyamori,H., Kinsen,H., Yoshizaki,T., Furukawa,M. and Sato,H. Cleavage of syndecan-1 by membrane type matrix metalloproteinase-1 stimulates cell migration J Biol Chem (17-10-2003) 278, 40764-40770. PubMed Europe PubMed DOI
[YEAR:3-6-2003]Higashi,S. and Miyazaki,K. Novel processing of beta-amyloid precursor protein catalyzed by membrane type 1 matrix metalloproteinase releases a fragment lacking the inhibitor domain against gelatinase A Biochemistry (3-6-2003) 42, 6514-6526. PubMed Europe PubMed DOI
[YEAR:10-11-2003]Holmbeck,K., Bianco,P., Chrysovergis,K., Yamada,S. and Birkedal-Hansen,H. MT1-MMP-dependent, apoptotic remodeling of unmineralized cartilage: a critical process in skeletal growth J Cell Biol (10-11-2003) 163, 661-671. PubMed Europe PubMed DOI PMC EPMC
[YEAR:11-7-2003]Hotary,K.B., Allen,E.D., Brooks,P.C., Datta,N.S., Long,M.W. and Weiss,S.J. Membrane type I matrix metalloproteinase usurps tumor growth control imposed by the three-dimensional extracellular matrix Cell (11-7-2003) 114, 33-45. PubMed Europe PubMed DOI
[YEAR:10-10-2003]Lee,M.H., Rapti,M. and Murphy,G. Unveiling the surface epitopes that render tissue inhibitor of metalloproteinase-1 inactive against membrane type 1-matrix metalloproteinase J Biol Chem (10-10-2003) 278, 40224-40230. PubMed Europe PubMed DOI
Luo,X.H., Liao,E.Y., Liao,H.J., Jin,Y., Zhou,H.D. and Huang,G. Recombinant matrix metalloproteinase-14 catalytic domain induces apoptosis in human osteoblastic SaOS-2 cells J Endocrinol Invest (2003) 26, 1111-1116. PubMed Europe PubMed
[YEAR:1-7-2003]Maquoi,E., Peyrollier,K., Noel,A., Foidart,J.M. and Frankenne,F. Regulation of membrane-type 1 matrix metalloproteinase activity by vacuolar H+-ATPases Biochem J (1-7-2003) 373, 19-24. PubMed Europe PubMed DOI PMC EPMC
[YEAR:1-10-2003]Remacle,A., Murphy,G. and Roghi,C. Membrane type I-matrix metalloproteinase (MT1-MMP) is internalised by two different pathways and is recycled to the cell surface J Cell Sci (1-10-2003) 116, 3905-3916. PubMed Europe PubMed DOI
[YEAR:8-5-2003]Seiki,M. Membrane-type 1 matrix metalloproteinase: a key enzyme for tumor invasion Cancer Lett (8-5-2003) 194, 1-11. PubMed Europe PubMed DOI
[YEAR:1-5-2003]Udayakumar,T.S., Chen,M.L., Bair,E.L., Von Bredow,D.C., Cress,A.E., Nagle,R.B. and Bowden,G.T. Membrane type-1-matrix metalloproteinase expressed by prostate carcinoma cells cleaves human laminin-5 beta3 chain and induces cell migration Cancer Res (1-5-2003) 63, 2292-2299. PubMed Europe PubMed

2002

Fukui,N., McAlinden,A., Zhu,Y., Crouch,E., Broekelmann,T.J., Mecham,R.P. and Sandell,L.J. Processing of type II procollagen amino propeptide by matrix metalloproteinases J Biol Chem (2002) 277, 2193-2201. PubMed Europe PubMed DOI
[YEAR:4-12-2002]Knauper,V., Bailey,L., Worley,J.R., Soloway,P., Patterson,M.L. and Murphy,G. Cellular activation of proMMP-13 by MT1-MMP depends on the C-terminal domain of MMP-13 FEBS Lett (4-12-2002) 532, 127-130. PubMed Europe PubMed DOI
[YEAR:28-6-2002]Kridel,S.J., Sawai,H., Ratnikov,B.I., Chen,E.I., Li,W., Godzik,A., Strongin,A.Y. and Smith,J.W. A unique substrate binding mode discriminates membrane type-1 matrix metalloproteinase from other matrix metalloproteinases J Biol Chem (28-6-2002) 277, 23788-23793. PubMed Europe PubMed DOI
Lafleur,M.A., Handsley,M.M., Knauper,V., Murphy,G. and Edwards,D.R. Endothelial tubulogenesis within fibrin gels specifically requires the activity of membrane-type-matrix metalloproteinases (MT-MMPs) J Cell Sci (2002) 115, 3427-3438. PubMed Europe PubMed
Lehti,K., Lohi,J., Juntunen,M.M., Pei,D. and Keski-Oja,J. Oligomerization through hemopexin and cytoplasmic domains regulates the activity and turnover of membrane-type 1 matrix metalloproteinase J Biol Chem (2002) 277, 8440-8448. PubMed Europe PubMed DOI
Palosaari,H., Ding,Y., Larmas,M., Sorsa,T., Bartlett,J.D., Salo,T. and Tjaderhane,L. Regulation and interactions of MT1-MMP and MMP-20 in human odontoblasts and pulp tissue in vitro J Dent Res (2002) 81, 354-359. PubMed Europe PubMed
[YEAR:1-3-2002]Ratnikov,B.I., Rozanov,D.V., Postnova,T.I., Baciu,P.G., Zhang,H., DiScipio,R.G., Chestukhina,G.G., Smith,J.W., Deryugina,E.I. and Strongin,A.Y. An alternative processing of integrin alpha(v) subunit in tumor cells by membrane type-1 matrix metalloproteinase J Biol Chem (1-3-2002) 277, 7377-7385. PubMed Europe PubMed DOI
[YEAR:11-9-2002]Rozanov,D.V., Ghebrehiwet,B., Ratnikov,B., Monosov,E.Z., Deryugina,E.I. and Strongin,A.Y. The cytoplasmic tail peptide sequence of membrane type-1 matrix metalloproteinase (MT1-MMP) directly binds to gC1qR, a compartment-specific chaperone-like regulatory protein FEBS Lett (11-9-2002) 527, 51-57. PubMed Europe PubMed DOI
[YEAR:15-3-2002]Rozanov,D.V., Ghebrehiwet,B., Postnova,T.I., Eichinger,A., Deryugina,E.I. and Strongin,A.Y. The hemopexin-like C-terminal domain of membrane type 1 matrix metalloproteinase regulates proteolysis of a multifunctional protein, gC1qR J Biol Chem (15-3-2002) 277, 9318-9325. PubMed Europe PubMed DOI
[YEAR:11-10-2002]Tam,E.M., Wu,Y.I., Butler,G.S., Stack,M.S. and Overall,C.M. Collagen binding properties of the membrane type-1 matrix metalloproteinase (MT1-MMP) hemopexin C domain. The ectodomain of the 44-kDa autocatalytic product of MT1-MMP inhibits cell invasion by disrupting native type I collagen cleavage J Biol Chem (11-10-2002) 277, 39005-39014. PubMed Europe PubMed DOI
[YEAR:19-7-2002]Toth,M., Hernandez-Barrantes,S., Osenkowski,P., Bernardo,M.M., Gervasi,D.C., Shimura,Y., Meroueh,O., Kotra,L.P., Galvez,B.G., Arroyo,A.G., Mobashery,S. and Fridman,R. Complex pattern of membrane type 1 matrix metalloproteinase shedding. Regulation by autocatalytic cells surface inactivation of active enzyme J Biol Chem (19-7-2002) 277, 26340-26350. PubMed Europe PubMed DOI

2001

[YEAR:2-3-2001]Atkinson,S.J., Patterson,M.L., Butler,M.J. and Murphy,G. Membrane type 1 matrix metalloproteinase and gelatinase A synergistically degrade type 1 collagen in a cell model FEBS Lett (2-3-2001) 491, 222-226. PubMed Europe PubMed DOI
[YEAR:25-5-2001]Belkin,A.M., Akimov,S.S., Zaritskaya,L.S., Ratnikov,B.I., Deryugina,E.I. and Strongin,A.Y. Matrix-dependent proteolysis of surface transglutaminase by membrane-type metalloproteinase regulates cancer cell adhesion and locomotion J Biol Chem (25-5-2001) 276, 18415-18422. PubMed Europe PubMed DOI
[YEAR:1-5-2001]Bigg,H.F., Morrison,C.J., Butler,G.S., Bogoyevitch,M.A., Wang,Z.P., Soloway,P.D. and Overall,C.M. Tissue inhibitor of metalloproteinases-4 inhibits but does not support the activation of gelatinase A via efficient inhibition of membrane type 1-matrix metalloproteinase Cancer Res (1-5-2001) 61, 3610-3618. PubMed Europe PubMed
[YEAR:15-2-2001]Deryugina,E.I., Ratnikov,B., Monosov,E., Postnova,T.I., DiScipio,R., Smith,J.W. and Strongin,A.Y. MT1-MMP initiates activation of pro-MMP-2 and integrin alphavbeta3 promotes maturation of MMP-2 in breast carcinoma cells Exp Cell Res (15-2-2001) 263, 209-223. PubMed Europe PubMed DOI
Gilles,C., Polette,M., Coraux,C., Tournier,J.M., Meneguzzi,G., Munaut,C., Volders,L., Rousselle,P., Birembaut,P. and Foidart,J.M. Contribution of MT1-MMP and of human laminin-5 gamma2 chain degradation to mammary epithelial cell migration J Cell Sci (2001) 114, 2967-2976. PubMed Europe PubMed
Han,Y.P., Tuan,T.L., Wu,H., Hughes,M. and Garner,W.L. TNF-alpha stimulates activation of pro-MMP2 in human skin through NF-(kappa)B mediated induction of MT1-MMP J Cell Sci (2001) 114, 131-139. PubMed Europe PubMed PMC EPMC
[YEAR:3-9-2001]Itoh,Y., Takamura,A., Ito,N., Maru,Y., Sato,H., Suenaga,N., Aoki,T. and Seiki,M. Homophilic complex formation of MT1-MMP facilitates proMMP-2 activation on the cell surface and promotes tumor cell invasion EMBO J (3-9-2001) 20, 4782-4793. PubMed Europe PubMed DOI PMC EPMC
[YEAR:28-5-2001]Kajita,M., Itoh,Y., Chiba,T., Mori,H., Okada,A., Kinoh,H. and Seiki,M. Membrane-type 1 matrix metalloproteinase cleaves CD44 and promotes cell migration J Cell Biol (28-5-2001) 153, 893-904. PubMed Europe PubMed DOI PMC EPMC
[YEAR:13-7-2001]Rozanov,D.V., Deryugina,E.I., Ratnikov,B.I., Monosov,E.Z., Marchenko,G.N., Quigley,J.P. and Strongin,A.Y. Mutation analysis of membrane type-1 matrix metalloproteinase (MT1-MMP). The role of the cytoplasmic tail Cys(574), the active site Glu(240), and furin cleavage motifs in oligomerization, processing, and self-proteolysis of MT1-MMP expressed in breast carcinoma cells J Biol Chem (13-7-2001) 276, 25705-25714. PubMed Europe PubMed DOI
Ruangpanit,N., Chan,D., Holmbeck,K., Birkedal-Hansen,H., Polarek,J., Yang,C., Bateman,J.F. and Thompson,E.W. Gelatinase A (MMP-2) activation by skin fibroblasts: dependence on MT1-MMP expression and fibrillar collagen form Matrix Biol (2001) 20, 193-203. PubMed Europe PubMed DOI
[YEAR:24-12-2001]Uekita,T., Itoh,Y., Yana,I., Ohno,H. and Seiki,M. Cytoplasmic tail-dependent internalization of membrane-type 1 matrix metalloproteinase is important for its invasion-promoting activity J Cell Biol (24-12-2001) 155, 1345-1356. PubMed Europe PubMed DOI PMC EPMC
[YEAR:31-8-2001]Williamson,R.A., Hutton,M., Vogt,G., Rapti,M., Knauper,V., Carr,M.D. and Murphy,G. Tyrosine 36 plays a critical role in the interaction of the AB loop of tissue inhibitor of metalloproteinases-2 with matrix metalloproteinase-14 J Biol Chem (31-8-2001) 276, 32966-32970. PubMed Europe PubMed DOI
[YEAR:11-5-2001]Zhuge,Y. and Xu,J. Rac1 mediates type I collagen-dependent MMP-2 activation: role in cell invasion across collagen barrier J Biol Chem (11-5-2001) 276, 16248-16256. PubMed Europe PubMed

2000

[YEAR:12-6-2000]Hotary,K., Allen,E., Punturieri,A., Yana,I. and Weiss,S.J. Regulation of cell invasion and morphogenesis in a three-dimensional type I collagen matrix by membrane-type matrix metalloproteinases 1, 2, and 3 J Cell Biol (12-6-2000) 149, 1309-1323. PubMed Europe PubMed DOI PMC EPMC
[YEAR:19-5-2000]Lehti,K., Valtanen,H., Wickstrom,S.A., Lohi,J. and Keski-Oja,J. Regulation of membrane-type-1 matrix metalloproteinase activity by its cytoplasmic domain J Biol Chem (19-5-2000) 275, 15006-15013. PubMed Europe PubMed DOI
[YEAR:15-12-2000]Overall,C.M., Tam,E., McQuibban,G.A., Morrison,C., Wallon,U.M., Bigg,H.F., King,A.E. and Roberts,C.R. Domain interactions in the gelatinase A.TIMP-2.MT1-MMP activation complex. The ectodomain of the 44-kDa form of membrane type-1 matrix metalloproteinase does not modulate gelatinase A activation J Biol Chem (15-12-2000) 275, 39497-39506. PubMed Europe PubMed DOI
Pap,T., Shigeyama,Y., Kuchen,S., Fernihough,J.K., Simmen,B., Gay,R.E., Billingham,M. and Gay,S. Differential expression pattern of membrane-type matrix metalloproteinases in rheumatoid arthritis Arthritis Rheum (2000) 43, 1226-1232. PubMed Europe PubMed DOI
Roderfeld,M., Buttner,F.H., Bartnik,E. and Tschesche,H. Expression of human membrane type 1 matrix metalloproteinase in Pichia pastoris Protein Expr Purif (2000) 19, 369-374. PubMed Europe PubMed DOI E
[YEAR:29-12-2000]Toth,M., Bernardo,M.M., Gervasi,D.C., Soloway,P.D., Wang,Z., Bigg,H.F., Overall,C.M., DeClerck,Y.A., Tschesche,H., Cher,M.L., Brown,S., Mobashery,S. and Fridman,R. Tissue inhibitor of metalloproteinase (TIMP)-2 acts synergistically with synthetic matrix metalloproteinase (MMP) inhibitors but not with TIMP-4 to enhance the (Membrane type 1)-MMP-dependent activation of pro-MMP-2 J Biol Chem (29-12-2000) 275, 41415-41423. PubMed Europe PubMed DOI
Valtanen,H., Lehti,K., Lohi,J. and Keski-Oja,J. Expression and purification of soluble and inactive mutant forms of membrane type 1 matrix metalloproteinase Protein Expr Purif (2000) 19, 66-73. PubMed Europe PubMed DOI E
Yana,I. and Weiss,S.J. Regulation of membrane type-1 matrix metalloproteinase activation by proprotein convertases Mol Biol Cell (2000) 11, 2387-2401. PubMed Europe PubMed PMC EPMC
Yonemura,Y., Endo,Y., Takino,T., Sakamoto,K., Bandou,E., Kinoshita,K., Fushida,S., Miwa,K., Sugiyama,K. and Sasaki,T. Membrane-type 1 matrix metalloproteinase enhances lymph node metastasis of gastric cancer Clin Exp Metastasis (2000) 18, 321-327. PubMed Europe PubMed DOI
[YEAR:11-4-2000]Zhou,Z., Apte,S.S., Soininen,R., Cao,R., Baaklini,G.Y., Rauser,R.W., Wang,J., Cao,Y. and Tryggvason,K. Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I Proc Natl Acad Sci U S A (11-4-2000) 97, 4052-4057. PubMed Europe PubMed DOI PMC EPMC

1999

[YEAR:1-10-1999]Holmbeck,K., Bianco,P., Caterina,J., Yamada,S., Kromer,M., Kuznetsov,S.A., Mankani,M., Robey,P.G., Poole,A.R., Pidoux,I., Ward,J.M. and Birkedal-Hansen,H. MT1-MMP-deficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnover Cell (1-10-1999) 99, 81-92. PubMed Europe PubMed DOI
Kanwar,Y.S., Ota,K., Yang,Q., Wada,J., Kashihara,N., Tian,Y. and Wallner,E.I. Role of membrane-type matrix metalloproteinase 1 (MT-1-MMP), MMP-2, and its inhibitor in nephrogenesis Am J Physiol (1999) 277, F934-F947. PubMed Europe PubMed
[YEAR:20-12-1999]Ohkubo,S., Miyadera,K., Sugimoto,Y., Matsuo,K., Wierzba,K. and Yamada,Y. Identification of substrate sequences for membrane type-1 matrix metalloproteinase using bacteriophage peptide display library Biochem Biophys Res Commun (20-12-1999) 266, 308-313. PubMed Europe PubMed DOI

1998

[YEAR:1-7-1998]Buttner,F.H., Hughes,C.E., Margerie,D., Lichte,A., Tschesche,H., Caterson,B. and Bartnik,E. Membrane type 1 matrix metalloproteinase (MT1-MMP) cleaves the recombinant aggrecan substrate rAgg1mut at the 'aggrecanase' and the MMP sites. Characterization of MT1-MMP catabolic activities on the interglobular domain of aggrecan Biochem J (1-7-1998) 333, 159-165. PubMed Europe PubMed PMC EPMC
[YEAR:25-12-1998]Cao,J., Drews,M., Lee,H.M., Conner,C., Bahou,W.F. and Zucker,S. The propeptide domain of membrane type 1 matrix metalloproteinase is required for binding of tissue inhibitor of metalloproteinases and for activation of pro-gelatinase A J Biol Chem (25-12-1998) 273, 34745-34752. PubMed Europe PubMed DOI
[YEAR:9-1-1998]d'Ortho,M.P., Stanton,H., Butler,M., Atkinson,S.J., Murphy,G. and Hembry,R.M. MT1-MMP on the cell surface causes focal degradation of gelatin films FEBS Lett (9-1-1998) 421, 159-164. PubMed Europe PubMed DOI
[YEAR:1-9-1998]Fernandez-Catalan,C., Bode,W., Huber,R., Turk,D., Calvete,J.J., Lichte,A., Tschesche,H. and Maskos,K. Crystal structure of the complex formed by the membrane type 1-matrix metalloproteinase with the tissue inhibitor of metalloproteinases-2, the soluble progelatinase A receptor EMBO J (1-9-1998) 17, 5238-5248. PubMed Europe PubMed DOI PMC EPMC S
[YEAR:3-7-1998]Fosang,A.J., Last,K., Fujii,Y., Seiki,M. and Okada,Y. Membrane-type 1 MMP (MMP-14) cleaves at three sites in the aggrecan interglobular domain FEBS Lett (3-7-1998) 430, 186-190. PubMed Europe PubMed DOI
Hayashi,K., Osada,S., Shofuda,K., Horikoshi,S., Shirato,I. and Tomino,Y. Enhanced expression of membrane type-1 matrix metalloproteinase in mesangial proliferative glomerulonephritis J Am Soc Nephrol (1998) 9, 2262-2271. PubMed Europe PubMed
[YEAR:26-6-1998]Kinoshita,T., Sato,H., Okada,A., Ohuchi,E., Imai,K., Okada,Y. and Seiki,M. TIMP-2 promotes activation of progelatinase a by membrane-type 1 matrix metalloproteinase immobilized on agarose beads J Biol Chem (26-6-1998) 273, 16098-16103. PubMed Europe PubMed DOI
[YEAR:1-9-1998]Lehti,K., Lohi,J., Valtanen,H. and Keski-Oja,J. Proteolytic processing of membrane-type-1 matrix metalloproteinase is associated with gelatinase A activation at the cell surface Biochem J (1-9-1998) 334, 345-353. PubMed Europe PubMed PMC EPMC
[YEAR:30-1-1998]Mucha,A., Cuniasse,P., Kannan,R., Beau,F., Yiotakis,A., Basset,P. and Dive,V. Membrane type-1 matrix metalloprotease and stromelysin-3 cleave more efficiently synthetic substrates containing unusual amino acids in their P1' positions J Biol Chem (30-1-1998) 273, 2763-2768. PubMed Europe PubMed DOI

1997

Apte,S.S., Fukai,N., Beier,D.R. and Olsen,B.R. The matrix metalloproteinase-14 (MMP-14) gene is structurally distinct from other MMP genes and is co-expressed with the TIMP-2 gene during mouse embryogenesis J Biol Chem (1997) 272, 25511-25517. PubMed Europe PubMed DOI
[YEAR:15-12-1997]d'Ortho,M.P., Will,H., Atkinson,S., Butler,G., Messent,A., Gavrilovic,J., Smith,B., Timpl,R., Zardi,L. and Murphy,G. Membrane-type matrix metalloproteinases 1 and 2 exhibit broad-spectrum proteolytic capacities comparable to many matrix metalloproteinases Eur J Biochem (15-12-1997) 250, 751-757. PubMed Europe PubMed
Mattei,M.G., Roeckel,N., Olsen,B.R. and Apte,S.S. Genes of the membrane-type matrix metalloproteinase (MT- MMP) gene family, MMP14, MMP15, and MMP16, localize to human chromosomes 14, 16, and 8, respectively Genomics (1997) 40, 168-169. PubMed Europe PubMed DOI
Ohuchi,E., Imai,K., Fujii,Y., Sato,H., Seiki,M. and Okada,Y. Membrane type 1 matrix metalloproteinase digests interstitial collagens and other extracellular matrix macromolecules J Biol Chem (1997) 272, 2446-2451. PubMed Europe PubMed DOI P
Okada,A., Tomasetto,C., Lutz,Y., Bellocq,J.P., Rio,M.C. and Basset,P. Expression of matrix metalloproteinases during rat skin wound healing: evidence that membrane type-1 matrix metalloproteinase is a stromal activator of pro-gelatinase A J Cell Biol (1997) 137, 67-77. PubMed Europe PubMed DOI PMC EPMC
Okumura,Y., Sato,H., Seiki,M. and Kido,H. Proteolytic activation of the precursor of membrane type 1 matrix metalloproteinase by human plasmin. A possible cell surface activator FEBS Lett (1997) 402, 181-184. PubMed Europe PubMed DOI
Sato,H., Tanaka,M., Takino,T., Inoue,M. and Seiki,M. Assignment of the human genes for membrane-type-1, -2, and -3 matrix metalloproteinases (MMP14, MMP15, and MMP16) to 14q12.2, 16q12.2-q21, and 8q21, respectively, by in situ hybridization Genomics (1997) 39, 412-413. PubMed Europe PubMed DOI
Ueno,H., Nakamura,H., Inoue,M., Imai,K., Noguchi,M., Sato,H., Seiki,M. and Okada,Y. Expression and tissue localization of membrane-types 1, 2, and 3 matrix metalloproteinases in human invasive breast carcinomas Cancer Res (1997) 57, 2055-2060. PubMed Europe PubMed

1996

Fishman,D.A., Bafetti,L.M. and Stack,M.S. Membrane-type matrix metalloproteinase expression and matrix metalloproteinase-2 activation in primary human ovarian epithelial carcinoma cells Invasion Metastasis (1996) 16, 150-159. PubMed Europe PubMed
Kinoh,H., Sato,H., Tsunezuka,Y., Takino,T., Kawashima,A., Okada,Y. and Seiki,M. MT-MMP, the cell surface activator of proMMP-2 (pro-gelatinase A), is expressed with its substrate in mouse tissue during embryogenesis J Cell Sci (1996) 109, 953-959. PubMed Europe PubMed
Knauper,V., Will,H., Lopez-Otin,C., Smith,B., Atkinson,S.J., Stanton,H., Hembry,R.M. and Murphy,G. Cellular mechanisms for human procollagenase-3 (MMP-13) activation. Evidence that MT1-MMP (MMP-14) and gelatinase A (MMP-2) are able to generate active enzyme J Biol Chem (1996) 271, 17124-17131. PubMed Europe PubMed DOI
Pei,D. and Weiss,S.J. Transmembrane-deletion mutants of the membrane-type matrix metalloproteinase-1 process progelatinase A and express intrinsic matrix-degrading activity J Biol Chem (1996) 271, 9135-9140. PubMed Europe PubMed
Sato,H. and Seiki,M. Membrane-type matrix metalloproteinases (MT-MMPs) in tumor metastasis J Biochem (1996) 119, 209-215. PubMed Europe PubMed
[YEAR:9-9-1996]Sato,H., Kinoshita,T., Takino,T., Nakayama,K. and Seiki,M. Activation of a recombinant membrane type 1-matrix metalloproteinase (MT1-MMP) by furin and its interaction with tissue inhibitor of metalloproteinases (TIMP)-2 FEBS Lett (9-9-1996) 393, 101-104. PubMed Europe PubMed DOI
Will,H., Atkinson,S.J., Butler,G.S., Smith,B. and Murphy,G. The soluble catalytic domain of membrane type 1 matrix metalloproteinase cleaves the propeptide of progelatinase A and initiates autoproteolytic activation. Regulation by TIMP-2 and TIMP-3 J Biol Chem (1996) 271, 17119-17123. PubMed Europe PubMed DOI

1995

[YEAR:18-5-1995]Pei,D. and Weiss,S.J. Furin-dependent intracellular activation of the human stromelysin-3 zymogen Nature (18-5-1995) 375, 244-247. PubMed Europe PubMed DOI

1994

Sato,H., Takino,T., Okada,Y., Cao,J., Shinagawa,A., Yamamoto,E. and Seiki,M. A matrix metalloproteinase expressed on the surface of invasive tumour cells Nature (1994) 370, 61-65. PubMed Europe PubMed DOI

1993

Brown,P.D., Bloxidge,R.E., Stuart,N.S., Gatter,K.C. and Carmichael,J. Association between expression of activated 72-kilodalton gelatinase and tumor spread in non-small-cell lung carcinoma J Natl Cancer Inst (1993) 85, 574-578. PubMed Europe PubMed
Brown,P.D., Bloxidge,R.E., Anderson,E. and Howell,A. Expression of activated gelatinase in human invasive breast carcinoma Clin Exp Metastasis (1993) 11, 183-189. PubMed Europe PubMed