$VAR1 = undef;

Summary for peptidase M10.013: matrix metallopeptidase-13

Names
MEROPS Name	matrix metallopeptidase-13
Other names	AgMMP3 (Anopheles gambiense), collagenase 3, matrix metalloproteinase 13, MMP-13, rat collagenase

Domain architecture

MEROPS Classification
Classification	Clan MA >> Subclan MA(M) >> Family M10 >> Subfamily A >> M10.013
Holotype	matrix metallopeptidase-13 (Mus musculus), Uniprot accession P33435 (peptidase unit: 103-283), MERNUM MER0001067
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Metallo
Peplist	Included in the Peplist with identifier PL00164
NC-IUBMB	Not yet included in IUBMB recommendations.
Proteolytic events	CutDB database (101 cleavages)
Activity status	human: active (Henriet & Eeckout, 2004) mouse: active (Botos et al., 1999)
Physiology	Plays a role in the turnover of collagen.
Knockout	Inactivation of the Mmp13 gene in mice by homologous recombination led to abnormal skeletal growth plate development (Stickens et al., 2004; Inada et al., 2004). A mutation in the human MMP13 gene causes the Missouri variant of spondyloepimetaphyseal dysplasia (Kennedy et al., 2005).
Other databases	TREEFAM	http://www.treefam.org/family/TF315428
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	g/Pa/-/gl/-/ga/- (based on 165 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	50	3	7	67	2	1	56	12
Pro	6	96	20	13	0	4	4	20
Ala	12	24	21	20	10	11	27	8
Val	5	6	10	3	17	16	9	9
Leu	12	11	22	1	55	9	3	13
Ile	4	4	3	2	18	6	2	5
Met	0	0	5	1	13	2	1	1
Phe	3	0	2	3	11	5	1	5
Tyr	0	0	5	1	8	2	4	2
Trp	0	0	1	0	1	2	0	0
Ser	3	4	15	13	5	10	17	10
Thr	6	1	2	3	3	12	5	7
Cys	0	0	0	2	0	0	0	1
Asn	2	0	4	5	1	8	0	3
Gln	4	5	16	5	6	14	2	5
Asp	8	3	1	3	1	4	10	9
Glu	9	3	2	10	2	6	8	7
Lys	2	0	12	6	3	14	2	1
Arg	6	1	14	6	3	27	2	5
His	4	3	2	1	3	6	2	2