Literature for peptidase M10.013: matrix metallopeptidase-13

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, R Splicing, I Inhibitor, L Localization. To select only the references relevant to a single topic, click the link above. See explanation.)

2026

Martin-Alonso,C., Alamdari,S., Samad,T.S., Yang,K.K., Bhatia,S.N. and Amini,A.P. Deep learning guided design of protease substrates Nat Commun (2026) 17, 54-54. PubMed Europe PubMed DOI PMC EPMC

2025

Mei,J., Schafer,N., Wei,P., Kong,Z., Li,S., Pann,P., Ehrnsperger,M., Johnstone,B., Matalova,E. and Grassel,S. Targeting Caspase-1 in osteoarthritis: multi-omics insights into the effects of VX-765 on human chondrocyte function and phenotype Front Immunol (2025) 16, 1677801-1677801. PubMed Europe PubMed DOI PMC EPMC

2024

Dibdiakova,K., Majercikova,Z., Galanda,T., Richterova,R., Kolarovszki,B., Racay,P. and Hatok,J. Relationship between the Expression of Matrix Metalloproteinases and Their Tissue Inhibitors in Patients with Brain Tumors Int J Mol Sci (2024) 25 PubMed Europe PubMed DOI PMC EPMC
Duncan,H.F., Kobayashi,Y., Yamauchi,Y. and Shimizu,E. The Reparative Function of MMP13 in Tertiary Reactionary Dentinogenesis after Tooth Injury Int J Mol Sci (2024) 25 PubMed Europe PubMed DOI PMC EPMC
Gao,X., Gao,L.F., Zhang,Z.Y., Jia,S. and Meng,C.Y. miR-99b-3p/Mmp13 axis regulates NLRP3 inflammasome-dependent microglial pyroptosis and alleviates neuropathic pain via the promotion of autophagy Int Immunopharmacol (2024) 126, 111331-111331. PubMed Europe PubMed DOI K
Hamm,P., Meinel,L. and Driessen,M.D. An Introductory Guide to Protease Sensitive Linker Design Using Matrix Metalloproteinase 13 as an Example ACS Biomater Sci Eng (2024) PubMed Europe PubMed DOI
Mastalier Manolescu,B.S., Lazar,A.M., Tiplica,G.S., Zurac,S.A., Rebosapca,A., Andreescu,B. and Popp,C.G. MMP1, MMP9, MMP11 and MMP13 in melanoma and its metastasis - key points in understanding the mechanisms and celerity of tumor dissemination Rom J Morphol Embryol (2024) 65, 45-52. PubMed Europe PubMed DOI
Wang,Y. Novel drug discovery approaches for MMP-13 inhibitors in the treatment of osteoarthritis Bioorg Med Chem Lett (2024) 114, 130009-130009. PubMed Europe PubMed DOI

2023

Cuffaro,D., Gimeno,A., Bernardoni,B.L., Di Leo,R., Pujadas,G., Garcia-Vallve,S., Nencetti,S., Rossello,A. and Nuti,E. Identification of N-Acyl Hydrazones as New Non-Zinc-Binding MMP-13 Inhibitors by Structure-Based Virtual Screening Studies and Chemical Optimization Int J Mol Sci (2023) 24 PubMed Europe PubMed DOI PMC EPMC
Gonzalez-Zamora,J., Hernandez,M., Recalde,S., Bezunartea,J., Montoliu,A., Bilbao-Malave,V., Llorente-Gonzalez,S., Garcia-Layana,A. and Fernandez-Robredo,P. Matrix Metalloproteinase 13 Is Associated with Age-Related Choroidal Neovascularization Antioxidants (Basel) (2023) 12 PubMed Europe PubMed DOI PMC EPMC

2022

Gomathi,K., Rohini,M., Vairamani,M. and Selvamurugan,N. Identification and characterization of TGF-beta1-responsive Runx2 acetylation sites for matrix Metalloproteinase-13 expression in osteoblastic cells Biochimie (2022) 201, 1-6. PubMed Europe PubMed DOI
Inagaki,J., Nakano,A., Hatipoglu,O.F., Ooka,Y., Tani,Y., Miki,A., Ikemura,K., Opoku,G., Ando,R., Kodama,S., Ohtsuki,T., Yamaji,H., Yamamoto,S., Katsuyama,E., Watanabe,S. and Hirohata,S. Potential of a Novel Chemical Compound Targeting Matrix Metalloprotease-13 for Early Osteoarthritis: An In Vitro Study Int J Mol Sci (2022) 23 PubMed Europe PubMed DOI PMC EPMC
Li,S., Pritchard,D.M. and Yu,L.G. Regulation and Function of Matrix Metalloproteinase-13 in Cancer Progression and Metastasis Cancers (Basel) (2022) 14 PubMed Europe PubMed DOI PMC EPMC V
Ponte,F., Kim,H.N., Warren,A., Iyer,S., Han,L., Mannen,E., Gomez-Acevedo,H., Nookaew,I., Almeida,M. and Manolagas,S.C. Mmp13 deletion in mesenchymal cells increases bone mass and may attenuate the cortical bone loss caused by estrogen deficiency Sci Rep (2022) 12, 10257-10257. PubMed Europe PubMed DOI PMC EPMC
Smith,S.S., Chu,D., Qu,T., Aggleton,J.A. and Schneider,R.A. Species-specific sensitivity to TGFbeta signaling and changes to the Mmp13 promoter underlie avian jaw development and evolution elife (2022) 11 PubMed Europe PubMed DOI PMC EPMC
Tang,K., Wu,Z., Sun,M., Huang,X., Sun,J., Shi,J., Wang,X., Miao,Z., Gao,P., Song,Y. and Wang,Z. Elevated MMP10/13 mediated barrier disruption and NF-kappaB activation aggravate colitis and colon tumorigenesis in both individual or full miR-148/152 family knockout mice Cancer Lett (2022) 529, 53-69. PubMed Europe PubMed DOI
Wilkinson,D.J., Falconer,A.M.D., Wright,H.L., Lin,H., Yamamoto,K., Cheung,K., Charlton,S.H., Arques,M.D.C., Janciauskiene,S., Refaie,R., Rankin,K.S., Young,D.A. and Rowan,A.D. Matrix metalloproteinase-13 is fully activated by neutrophil elastase and inactivates its serpin inhibitor, alpha-1 antitrypsin: Implications for osteoarthritis FEBS J (2022) 289, 121-139. PubMed Europe PubMed
Zhang,X., Ma,L., Shen,Y., Zhang,C., Hou,B. and Zhou,Y. Transcription factor paired related homeobox 1 (PRRX1) activates matrix metalloproteinases (MMP)13, which promotes the dextran sulfate sodium-induced inflammation and barrier dysfunction of NCM460 cells Bioengineered (2022) 13, 645-654. PubMed Europe PubMed DOI PMC EPMC K
Zhang,Y., Li,Z., He,Y., Liu,Y., Mi,G. and Chen,J. T-2 toxin induces articular cartilage damage by increasing the expression of MMP-13 via the TGF-beta receptor pathway Hum Exp Toxicol (2022) 41, 9603271221075555-9603271221075555. PubMed Europe PubMed DOI

2021

Furlan,A.G., Spanou,C.E.S., Godwin,A.R.F., Wohl,A.P., Zimmermann,L.A., Imhof,T., Koch,M., Baldock,C. and Sengle,G. A new MMP-mediated prodomain cleavage mechanism to activate bone morphogenetic proteins from the extracellular matrix FASEB J (2021) 35, e21353-e21353. PubMed Europe PubMed DOI
Hu,Q. and Ecker,M. Overview of MMP-13 as a Promising Target for the Treatment of Osteoarthritis Int J Mol Sci (2021) 22, 1742-1742. PubMed Europe PubMed DOI PMC EPMC V
Laghezza,A., Piemontese,L., Brunetti,L., Caradonna,A., Agamennone,M., Loiodice,F. and Tortorella,P. (2-Aminobenzothiazole)-Methyl-1,1-Bisphosphonic Acids: Targeting Matrix Metalloproteinase 13 Inhibition to the Bone Pharmaceuticals (Basel) (2021) 14 PubMed Europe PubMed DOI I
Liang,D. and Zhang,Z. MicroRNA-27b-3p inhibits the proliferation and invasion of cutaneous squamous cell carcinoma by targeting EGFR and MMP-13 Oncol Lett (2021) 22, 729-729. PubMed Europe PubMed DOI PMC EPMC
Park,J.Y., Bae,H.C., Pyo,S.H., Lee,M.C. and Han,H.S. TGFbeta1-Induced Transglutaminase-2 Triggers Catabolic Response in Osteoarthritic Chondrocytes by Modulating MMP-13 Tissue Eng Regen Med (2021) 18, 831-840. PubMed Europe PubMed DOI
Taylor,S.J., Abeywardane,A., Liang,S., Xiong,Z., Proudfoot,J.R., Farmer,B.S., Gao,D.A., Heim-Riether,A., Smith-Keenan,L.L., Muegge,I., Yu,Y., Zhang,Q., Souza,D., Panzenbeck,M., Goldberg,D., Hill-Drzewi,M., Margarit,M., Collins,B., Li,J.X., Zuvela-Jelaska,L., Li,J. and Farrow,N.A. Indole Inhibitors of MMP-13 for Arthritic Disorders ACS Omega (2021) 6, 18635-18650. PubMed Europe PubMed DOI PMC EPMC I
Zapico,J.M., Acosta,L., Pastor,M., Rangasamy,L., Marquez-Cantudo,L., Coderch,C., Ortin,I., Nicolau-Sanus,M., Puchades-Carrasco,L., Pineda-Lucena,A., Majali-Martinez,A., Ramos,P., de Pascual-Teresa,B. and Ramos,A. Design and Synthesis of Water-Soluble and Potent MMP-13 Inhibitors with Activity in Human Osteosarcoma Cells Int J Mol Sci (2021) 22, 9976-9976. PubMed Europe PubMed DOI PMC EPMC I

2020

Carreca,A.P., Pravata,V.M., Markham,M., Bonelli,S., Murphy,G., Nagase,H., Troeberg,L. and Scilabra,S.D. TIMP-3 facilitates binding of target metalloproteinases to the endocytic receptor LRP-1 and promotes scavenging of MMP-1 Sci Rep (2020) 10, 12067-12067. PubMed Europe PubMed DOI PMC EPMC
El Ashry,E.S.H., Awad,L.F., Teleb,M., Ibrahim,N.A., Abu-Serie,M.M. and Abd Al Moaty,M.N. Structure-based design and optimization of pyrimidine- and 1,2,4-triazolo[4,3-a]pyrimidine-based matrix metalloproteinase-10/13 inhibitors via Dimroth rearrangement towards targeted polypharmacology Bioorg Chem (2020) 96, 103616-103616. PubMed Europe PubMed DOI I
Fields,G., Knapinska,A.M., Singh,C., Drotleff,G., Blanco,D., Chai,C., Schwab,J. and Herd,A. Matrix Metalloproteinase 13 Inhibitors for Modulation of Osteoclastogenesis: Enhancement of Solubility and Stability ChemMedChem (2020) PubMed Europe PubMed DOI I
Guimaraes-Stabili,M.R., de Medeiros,M.C., Rossi,D., Camilli,A.C., Zanelli,C.F., Valentini,S.R., Spolidorio,L.C., Kirkwood,K.L. and Rossa,C., Jr. Silencing matrix metalloproteinase-13 (Mmp-13) reduces inflammatory bone resorption associated with LPS-induced periodontal disease in vivo Clin Oral Investig (2020) 25, 3161-3172. PubMed Europe PubMed DOI
Howes,J.M., Knauper,V., Malcor,J.D. and Farndale,R.W. Cleavage by MMP-13 renders VWF unable to bind to collagen but increases its platelet reactivity J Thromb Haemost (2020) 18, 942-954. PubMed Europe PubMed DOI
Lan,Q., Lu,R., Chen,H., Pang,Y., Xiong,F., Shen,C., Qin,Z., Zheng,L., Xu,G. and Zhao,J. MMP-13 enzyme and pH responsive theranostic nanoplatform for osteoarthritis J Nanobiotechnology (2020) 18, 117-117. PubMed Europe PubMed DOI PMC EPMC
Li,L., Zhang,J. and Akimenko,M.A. Inhibition of mmp13a during zebrafish fin regeneration disrupts fin growth, osteoblasts differentiation, and laminin organization Dev Dyn (2020) 249, 187-198. PubMed Europe PubMed DOI K
Moffitt,L.R., Bilandzic,M., Wilson,A.L., Chen,Y., Gorrell,M.D., Oehler,M.K., Plebanski,M. and Stephens,A.N. Hypoxia Regulates DPP4 Expression, Proteolytic Inactivation, and Shedding from Ovarian Cancer Cells Int J Mol Sci (2020) 21 PubMed Europe PubMed DOI PMC EPMC
Roy,H.S., Dubey,G., Sharma,V.K., Bharatam,P.V. and Ghosh,D. Molecular docking and molecular dynamics to identify collagenase inhibitors as lead compounds to address osteoarthritis J Biomol Struct Dyn (2020) , 1-13. PubMed Europe PubMed DOI I
Small,C.D., El-Khoury,M., Deslongchamps,G., Benfey,T.J. and Crawford,B.D. Matrix metalloproteinase 13 activity is required for normal and hypoxia-induced precocious hatching in zebrafish embryos J Dev Biol (2020) 8, 3-3. PubMed Europe PubMed DOI

2019

Gall,F.M., Hohl,D., Frasson,D., Wermelinger,T., Mittl,P.R.E., Sievers,M. and Riedl,R. Drug design inspired by nature: crystallographic detection of an auto-tailored protease inhibitor template Angew Chem Int Ed Engl (2019) 58, 4051-4055. PubMed Europe PubMed DOI I
Huang,S., Feng,K. and Ren,Y. Molecular modelling studies of quinazolinone derivatives as MMP-13 inhibitors by QSAR, molecular docking and molecular dynamics simulations techniques MedChemComm (2019) 10, 101-115. PubMed Europe PubMed DOI PMC EPMC I
Paumier,J.M. and Thinakaran,G. Matrix metalloproteinase 13, a new target for therapy in Alzheimer's disease Genes Dis (2019) 6, 1-2. PubMed Europe PubMed DOI PMC EPMC T
Satish Kumar,K., Velayutham,R. and Roy,K.K. A systematic computational analysis of human matrix metalloproteinase 13 (MMP-13) crystal structures and structure-based identification of prospective drug candidates as MMP-13 inhibitors repurposable for osteoarthritis J Biomol Struct Dyn (2019) , 1-13. PubMed Europe PubMed DOI S I
Seidl,C.I., Fulga,T.A. and Murphy,C.L. CRISPR-Cas9 targeting of MMP13 in human chondrocytes leads to significantly reduced levels of the metalloproteinase and enhanced type II collagen accumulation Osteoarthritis Cartilage (2019) 27, 140-147. PubMed Europe PubMed DOI
Zhu,B.L., Long,Y., Luo,W., Yan,Z., Lai,Y.J., Zhao,L.G., Zhou,W.H., Wang,Y.J., Shen,L.L., Liu,L., Deng,X.J., Wang,X.F., Sun,F. and Chen,G.J. MMP13 inhibition rescues cognitive decline in Alzheimer transgenic mice via BACE1 regulation Brain (2019) 142, 176-192. PubMed Europe PubMed DOI I

2018

Fuerst,R., Yong Choi,J., Knapinska,A.M., Smith,L., Cameron,M.D., Ruiz,C., Fields,G.B. and Roush,W.R. Development of matrix metalloproteinase-13 inhibitors - a structure-activity/structure-property relationship study Bioorg Med Chem (2018) 26, 4984-4995. PubMed Europe PubMed DOI I
Wan,Y., Li,W., Liao,Z., Yan,M., Chen,X. and Tang,Z. Selective MMP-13 inhibitors: promising agents for the therapy of osteoarthritis Curr Med Chem (2018) 27, 3753-3769. PubMed Europe PubMed DOI I

2017

Choi,J.Y. and Fuerst,R. Virtual high-throughput screening for matrix metalloproteinase inhibitors Methods Mol Biol (2017) 1579, 259-271. PubMed Europe PubMed DOI I
Choi,J.Y., Fuerst,R., Knapinska,A.M., Taylor,A.B., Smith,L., Cao,X., Hart,P.J., Fields,G.B. and Roush,W.R. Structure-based design and synthesis of potent and selective matrix metalloproteinase 13 inhibitors J Med Chem (2017) 60, 5816-5825. PubMed Europe PubMed DOI I
Fischer,T. and Riedl,R. Targeted fluoro positioning for the discovery of a potent and highly selective matrix metalloproteinase inhibitor ChemistryOpen (2017) 6, 167- PubMed Europe PubMed DOI I
Hugenberg,V., Wagner,S., Kopka,K., Schafers,M., Schuit,R.C., Windhorst,A.D. and Hermann,S. Radiolabeled selective matrix metalloproteinase 13 (MMP-13) inhibitors: (radio)syntheses and in vitro and first in vivo evaluation J Med Chem (2017) 60, 307-321. PubMed Europe PubMed DOI I
Inanc,S., Keles,D. and Oktay,G. An improved collagen zymography approach for evaluating the collagenases MMP-1, MMP-8, and MMP-13 Biotechniques (2017) 63, 174-180. PubMed Europe PubMed DOI L
Nara,H., Kaieda,A., Sato,K., Naito,T., Mototani,H., Oki,H., Yamamoto,Y., Kuno,H., Santou,T., Kanzaki,N., Terauchi,J., Uchikawa,O. and Kori,M. Discovery of novel, highly potent, and selective matrix metalloproteinase (MMP)-13 inhibitors with a 1,2,4-triazol-3-yl moiety as a zinc binding group using a structure-based design approach J Med Chem (2017) 60, 608-626. PubMed Europe PubMed DOI I
Ramezani,M. and Shamsara,J. Virtual screening on MMP-13 led to discovering new inhibitors including a non-zinc binding and a micro molar one: a successful example of receptor selection according to cross-docking results for a flexible enzyme Comb Chem High Throughput Screen (2017) 20, 719-725. PubMed Europe PubMed DOI I
Xie,X.W., Wan,R.Z. and Liu,Z.P. Recent research advances in selective matrix metalloproteinase-13 inhibitors as anti-osteoarthritis agents ChemMedChem (2017) 12, 1157-1168. PubMed Europe PubMed DOI V I

2016

Bartmann,J., Frankenberger,M., Neurohr,C., Eickelberg,O., Noessner,E. and von Wulffen,W. A novel role of MMP-13 for murine DC function: its inhibition dampens T-cell activation Int Immunol (2016) 28, 473-487. PubMed Europe PubMed DOI I
Fischer,T. and Riedl,R. Molecular recognition of the catalytic zinc(II) ion in MMP-13: structure-based evolution of an allosteric inhibitor to dual binding mode inhibitors with improved lipophilic ligand efficiencies Int J Mol Sci (2016) 17, 314-314. PubMed Europe PubMed DOI I
Nakatani,T., Chen,T. and Partridge,N.C. MMP-13 is one of the critical mediators of the effect of HDAC4 deletion on the skeleton Bone (2016) 90, 142-151. PubMed Europe PubMed DOI
Nara,H., Sato,K., Kaieda,A., Oki,H., Kuno,H., Santou,T., Kanzaki,N., Terauchi,J., Uchikawa,O. and Kori,M. Design, synthesis, and biological activity of novel, potent, and highly selective fused pyrimidine-2-carboxamide-4-one-based matrix metalloproteinase (MMP)-13 zinc-binding inhibitors Bioorg Med Chem (2016) 24, 6149-6165. PubMed Europe PubMed DOI I
Nirmala,G., Adimulam,Y.B. and Seetharamaiah,P. Computational molecular docking and structural specificity of bipyrazoles as non-zinc chelating inhibitors of MMP-13 Int J Comp Biol Drug Des (2016) 9, 162-171. DOI I
Pizio,A.D., Agamennone,M. and Tortorella,P. Non-zinc-binding inhibitors of MMP-13: GRID-based approaches to rationalize the binding process Curr Top Med Chem (2016) 16, 449-459. PubMed Europe PubMed S I
Ruminski,P.G., Massa,M., Strohbach,J., Hanau,C.E., Schmidt,M., Scholten,J.A., Fletcher,T.R., Hamper,B.C., Carroll,J.N., Shieh,H.S., Caspers,N., Collins,B., Grapperhaus,M., Palmquist,K.E., Collins,J., Baldus,J.E., Hitchcock,J., Kleine,H.P., Rogers,M.D., McDonald,J., Munie,G.E., Messing,D.M., Portolan,S., Whiteley,L.O., Sunyer,T. and Schnute,M.E. Discovery of N-(4-fluoro-3-methoxybenzyl)-6-(2-(((2S,5R)-5-(hydroxymethyl)-14-dioxan-2-yl)methyl)-2H-tetrazol-5-yl)-2-methylpyrimidine-4-carboxamide. A highly selective and orally bioavailable matrix metalloproteinase-13 inhibitor for the potential treatment of osteoarthritis J Med Chem (2016) 59, 313-327. PubMed Europe PubMed DOI I
Shamsara,J. Considering rotatability of hydroxyl groups for the active site residues of MMP-13 in retrospective virtual screening campaigns Open Med Chem J (2016) 10, 1-6. PubMed Europe PubMed DOI PMC EPMC
Wen,H., Qin,Y., Zhong,W., Li,C., Liu,X. and Shen,Y. Trivalent metal ions based on inorganic compounds with in vitro inhibitory activity of matrix metalloproteinase 13 Enzyme Microb Technol (2016) 92, 9-17. PubMed Europe PubMed DOI I
Zhang,X., Wang,J., Liu,M., Wang,S., Zhang,H. and Zhao,Y. Cloning, expression, purification, and characterization of the catalytic domain of sika deer MMP-13 Protein Expr Purif (2016) 127, 16-21. PubMed Europe PubMed DOI

2015

Bhowmick,M., Stawikowska,R., Tokmina-Roszyk,D. and Fields,G.B. Matrix metalloproteinase inhibition by heterotrimeric triple-helical peptide transition state analogues Chembiochem (2015) 16, 1084-1092. PubMed Europe PubMed DOI I
Santamaria,S., Nuti,E., Cercignani,G., La Regina,G., Silvestri,R., Supuran,C.T. and Rossello,A. Kinetic characterization of 4,4'-biphenylsulfonamides as selective non-zinc binding MMP inhibitors J Enzyme Inhib Med Chem (2015) 30, 947-954. PubMed Europe PubMed DOI I
Shih,C.L. and Ajuwon,K.M. Inhibition of MMP-13 prevents diet-induced obesity in mice and suppresses adipogenesis in 3T3-L1 preadipocytes Mol Biol Rep (2015) 42, 1225-1232. PubMed Europe PubMed DOI I
Stawikowski,M.J., Stawikowska,R. and Fields,G.B. Collagenolytic matrix metalloproteinase activities toward peptomeric triple-helical substrates Biochemistry (2015) 54, 3110-3121. PubMed Europe PubMed DOI P
Wang,W., Zeng,L., Wang,Z.M., Zhang,S., Rong,X.F. and Li,R.H. Ginsenoside Rb1 inhibits matrix metalloproteinase 13 through down-regulating Notch signaling pathway in osteoarthritis Exp Biol Med (Maywood) (2015) 240, 1614-1621. PubMed Europe PubMed DOI
Yu,X., Wei,F., Yu,J., Zhao,H., Jia,L., Ye,Y., Du,R., Ren,X. and Li,H. Matrix metalloproteinase 13: a potential intermediate between low expression of microRNA-125b and increasing metastatic potential of non-small cell lung cancer Cancer Genet (2015) 208, 76-84. PubMed Europe PubMed DOI
Zhang,R., Zhang,L., Li,C., Chen,B., Li,Q., Fang,X. and Shen,Y. Refolding of recombinant histidine-tagged catalytic domain of MMP-13 from Escherichia coli with ion-exchange chromatography for higher bioactivity J Liq Chromatogr Relat Technol (2015) 38, 561-568. DOI E

2014

Akagi,R., Sasho,T., Saito,M., Endo,J., Yamaguchi,S., Muramatsu,Y., Mukoyama,S., Akatsu,Y., Katsuragi,J., Fukawa,T. and Takahashi,K. Effective knock down of matrix metalloproteinase-13 by an intra-articular injection of small interfering RNA (siRNA) in a murine surgically-induced osteoarthritis model J Orthop Res (2014) 32, 1175-1180. PubMed Europe PubMed DOI K
Bonaf‚,L., Liang,J., Gorna,M.W., Zhang,Q., Ha-Vinh,R., Campos-Xavier,A.B., Unger,S., Beckmann,J.S., Le,B.c.A., Stevenson,B., Giedion,A., Liu,X., Superti-Furga,G., Wang,W., Spahr,A. and Superti-Furga,A. MMP13 mutations are the cause of recessive metaphyseal dysplasia, Spahr type Am J Med Genet A (2014) 164A, 1175-1179. PubMed Europe PubMed
Gao,P., Yang,J.-L., Zhao,H., You,J.-H. and Hu,Y. Common polymorphism in the MMP-13 gene may contribute to the risk of human cancers: a meta-analysis Tumour Biol (2014) 35, 10137-10148. PubMed Europe PubMed DOI M
Howes,J.M., Bihan,D., Slatter,D.A., Hamaia,S.W., Packman,L.C., Knauper,V., Visse,R. and Farndale,R.W. The recognition of collagen and triple-helical Toolkit peptides by MMP-13: sequence specificity for binding and cleavage J Biol Chem (2014) 289, 24091-24101. PubMed Europe PubMed DOI P
Iwao,Y., Shiga,K., Shiroshita,A., Yoshikawa,T., Sakiie,M., Ueno,T., Ueno,S., Ijiri,T.W. and Sato,K.-I. The need of MMP-2 on the sperm surface for Xenopus fertilization: its role in a fast electrical block to polyspermy Mech Dev (2014) 134, 80-95. PubMed Europe PubMed DOI
Joo,N.E., Miao,D., Bermudez,M., Stallcup,W.B. and Kapila,Y.L. Shedding of NG2 by MMP-13 attenuates anoikis DNA Cell Biol (2014) 33, 854-862. PubMed Europe PubMed DOI
Li,B.-K., Cong,Y., Tian,Z.-Y. and Xue,Y. Predicting and virtually screening the selective inhibitors of MMP-13 over MMP-1 by molecular descriptors and machine learning methods Wuli Huaxue Xuebao Acta Phys Chim Sin (2014) 30, 171-182. DOI I
Li,C., Zhang,R., Chen,B., Li,Q., Fang,X. and Shen,Y. Purification of recombinant histidine-tagged catalytic domain of MMP-13 in one-step using affinity column and renaturation of it with histidine-tag J Liq Chromatogr Relat Technol (2014) 37, 2118-2130. DOI E
Lim,N.H., Meinjohanns,E., Bou-Gharios,G., Gompels,L.L., Nuti,E., Rossello,A., Devel,L., Dive,V., Meldal,M. and Nagase,H. In vivo imaging of matrix metalloproteinase 12 and matrix metalloproteinase 13 activities in the mouse model of collagen-induced arthritis Arthritis Rheum (2014) 66, 589-598. PubMed Europe PubMed DOI L I
Meides,A., Gutschalk,C.M., Devel,L., Beau,F., Czarny,B., Hensler,S., Neugebauer,J., Dive,V., Angel,P. and Mueller,M.M. Effects of selective MMP-13 inhibition in squamous cell carcinoma depend on estrogen Int J Cancer (2014) 135, 2749-2759. PubMed Europe PubMed DOI I
Nara,H., Sato,K., Naito,T., Mototani,H., Oki,H., Yamamoto,Y., Kuno,H., Santou,T., Kanzaki,N., Terauchi,J., Uchikawa,O. and Kori,M. Thieno[2,3-d]pyrimidine-2-carboxamides bearing a carboxybenzene group at 5-position: highly potent, selective, and orally available MMP-13 inhibitors interacting with the S1'' binding site Bioorg Med Chem (2014) 22, 5487-5505. PubMed Europe PubMed DOI I
Nara,H., Sato,K., Naito,T., Mototani,H., Oki,H., Yamamoto,Y., Kuno,H., Santou,T., Kanzaki,N., Terauchi,J., Uchikawa,O. and Kori,M. Discovery of novel, highly potent, and selective quinazoline-2-carboxamide-based matrix metalloproteinase (MMP)-13 inhibitors without a zinc binding group using a structure-based design approach J Med Chem (2014) 57, 8886-8902. PubMed Europe PubMed DOI I
Spicer,T.P., Jiang,J., Taylor,A.B., Choi,J.Y., Hart,P.J., Roush,W.R., Fields,G.B., Hodder,P.S. and Minond,D. Characterization of selective exosite-binding inhibitors of matrix metalloproteinase 13 that prevent articular cartilage degradation in vitro J Med Chem (2014) 57, 9598-9611. PubMed Europe PubMed DOI I
Xi,L., Li,S., Yao,X., Wei,Y., Li,J., Liu,H. and Wu,X. In silico study combining docking and QSAR methods on a series of matrix metalloproteinase 13 inhibitors Arch Pharm (Weinheim) (2014) 347, 825-833. PubMed Europe PubMed DOI I
Zhu,L., Ma,Y., Kiesewetter,D.O., Wang,Y., Lang,L., Lee,S., Niu,G. and Chen,X. Rational design of matrix metalloproteinase-13 activatable probes for enhanced specificity ACS Chem Biol (2014) 9, 510-516. PubMed Europe PubMed DOI L

2013

Fischer,T. and Riedl,R. Strategic targeting of multiple water-mediated interactions: a concise and rational structure-based design approach to potent and selective MMP-13 inhibitors ChemMedChem (2013) 8, 1457-1461. PubMed Europe PubMed DOI I
Hugenberg,V., Riemann,B., Hermann,S., Schober,O., Schafers,M., Szardenings,K., Lebedev,A., Gangadharmath,U., Kolb,H., Walsh,J., Zhang,W., Kopka,K. and Wagner,S. Inverse 1,2,3-triazole-1-yl-ethyl substituted hydroxamates as highly potent matrix metalloproteinase inhibitors: (Radio)synthesis, in vitro and first in vivo evaluation J Med Chem (2013) 56, 6858-6870. PubMed Europe PubMed DOI I
Kalva,S., Saranyah,K., Suganya,P.R., Nisha,M. and Saleena,L.M. Potent inhibitors precise to S1' loop of MMP-13, a crucial target for osteoarthritis J Mol Graph Model (2013) 44, 297-310. PubMed Europe PubMed DOI I
Lei,H., Leong,D., Smith,L.R. and Barton,E.R. Matrix metalloproteinase 13 is a new contributor to skeletal muscle regeneration and critical for myoblast migration Am J Physiol Cell Physiol (2013) 305, C529-C538. PubMed Europe PubMed DOI
Li,N.G., Tang,Y.P. and Duan,J.A. New selective inhibitors of MMP-13 for inflammatory diseases: a patent evaluation (W02012151158) Expert Opin Ther Pat (2013) 23, 669-675. PubMed Europe PubMed DOI I
Lu,H.B., Wang,S.H., Li,Q.M. and Wang,Y.S. Design, synthesis and evaluation of 6-oxo-1, 6-dihydropyrimidine-2,5-dicarboxamide derivatives as MMP 13 inhibitors Chem Res Chin Univ (2013) 29, 67-70. DOI I
Miller,R.E., Lu,Y., Tortorella,M.D. and Malfait,A.M. Genetically engineered mouse models reveal the importance of proteases as osteoarthritis drug targets Curr Rheumatol Rep (2013) 15, 350-350. PubMed Europe PubMed DOI K
Stura,E.A., Visse,R., Cuniasse,P., Dive,V. and Nagase,H. Crystal structure of full-length human collagenase 3 (MMP-13) with peptides in the active site defines exosites in the catalytic domain FASEB J (2013) 27, 4395-4405. PubMed Europe PubMed DOI S
Vandenbroucke,R.E., Dejonckheere,E., Van Hauwermeiren,F., Lodens,S., De Rycke,R., Van Wonterghem,E., Staes,A., Gevaert,K., Lopez-Otin,C. and Libert,C. Matrix metalloproteinase 13 modulates intestinal epithelial barrier integrity in inflammatory diseases by activating TNF EMBO Mol Med (2013) 5, 932-948. PubMed Europe PubMed DOI P
Zhong,H.A., Arbiser,J. and Bowen,J.P. Selectivity, binding affinity, and ionization state of matrix metalloproteinase inhibitors Curr Pharm Des (2013) 19, 4701-4713. PubMed Europe PubMed DOI I

2012

Gege,C., Bao,B., Bluhm,H., Boer,J., Gallagher,B.M., Korniski,B., Powers,T.S., Steeneck,C., Taveras,A.G. and Baragi,V.M. Discovery and evaluation of a non-Zn chelating, selective matrix metalloproteinase 13 (MMP-13) inhibitor for potential intra-articular treatment of osteoarthritis J Med Chem (2012) 55, 709-716. PubMed Europe PubMed DOI I
Henriet,P. and Eeckhout,Y. Matrix metallopeptidase-13/collagenase 3 [ISSN:978-0-12-407744-7] (2012) 3, 734-744. DOI
La Pietra,V., Marinelli,L., Cosconati,S., Di Leva,F.S., Nuti,E., Santamaria,S., Pugliesi,I., Morelli,M., Casalini,F., Rossello,A., La Motta,C., Taliani,S., Visse,R., Nagase,H., Da Settimo,F. and Novellino,E. Identification of novel molecular scaffolds for the design of MMP-13 inhibitors: a first round of lead optimization Eur J Med Chem (2012) 47, 143-152. PubMed Europe PubMed DOI I
Naito,S., Takahashi,T., Onoda,J., Yamauchi,A., Kawai,T., Kishino,J., Yamane,S., Fujii,I., Fukui,N. and Numata,Y. Development of a neutralizing antibody specific for the active form of matrix metalloproteinase-13 Biochemistry (2012) 51, 8877-8884. PubMed Europe PubMed DOI
Santamaria,S., Nuti,E., Cercignani,G., Marinelli,L., La Pietra,V., Novellino,E. and Rossello,A. N-O-Isopropyl sulfonamido-based hydroxamates: kinetic characterisation of a series of MMP-12/MMP-13 dual target inhibitors Biochem Pharmacol (2012) 84, 813-820. PubMed Europe PubMed DOI I
Troeberg,L. and Nagase,H. Proteases involved in cartilage matrix degradation in osteoarthritis Biochim Biophys Acta (2012) 1824, 133-145. PubMed Europe PubMed DOI V

2011

Barta,T.E., Becker,D.P., Bedell,L.J., Easton,A.M., Hockerman,S.L., Kiefer,J., Munie,G.E., Mathis,K.J., Li,M.H., Rico,J.G., Villamil,C.I. and Williams,J.M. MMP-13 selective alpha-sulfone hydroxamates: a survey of P1' heterocyclic amide isosteres Bioorg Med Chem Lett (2011) 21, 2820-2822. PubMed Europe PubMed DOI I
Chakrabarti,B., Bairagya,H.R., Mallik,P., Mukhopadhyay,B.P. and Bera,A.K. An insight to conserved water molecular dynamics of catalytic and structural Zn(+2) ions in matrix metalloproteinase 13 of human J Biomol Struct Dyn (2011) 28, 503-516. PubMed Europe PubMed DOI S
Fobian,Y.M., Freskos,J.N., Barta,T.E., Bedell,L.J., Heintz,R., Kassab,D.J., Kiefer,J.R., Mischke,B.V., Molyneaux,J.M., Mullins,P., Munie,G.E. and Becker,D.P. MMP-13 selective alpha-sulfone hydroxamates: Identification of selective P1' amides Bioorg Med Chem Lett (2011) 21, 2823-2825. PubMed Europe PubMed DOI I
Goldring,M.B., Otero,M., Plumb,D.A., Dragomir,C., Favero,M., El Hachem,H., Hashimoto,K., Roach,H.I., Olivotto,E., Borzi,R.M. and Marcu,K.B. Roles of inflammatory and anabolic cytokines in cartilage metabolism: signals and multiple effectors converge upon MMP-13 regulation in osteoarthritis Eur Cell Mater (2011) 21, 202-220. PubMed Europe PubMed
Li,N.G., Shi,Z.H., Tang,Y.P., Wang,Z.J., Song,S.L., Qian,L.H., Qian,D.W. and Duan,J.A. New hope for the treatment of osteoarthritis through selective inhibition of MMP-13 Curr Med Chem (2011) 18, 977-1001. PubMed Europe PubMed DOI I
Mazurek,S.G., Li,J., Nabozny,G.H., Reinhart,G.A., Muthukumarana,A.C., Harrison,P.C. and Fryer,R.M. Functional biomarkers of musculoskeletal syndrome (MSS) for early in vivo screening of selective MMP-13 inhibitors J Pharmacol Toxicol Methods (2011) 64, 89-96. PubMed Europe PubMed DOI I
Moroy,G., Bourguet,E., Decarme,M., Sapi,J., Alix,A.J., Hornebeck,W. and Lorimier,S. Inhibition of human leukocyte elastase, plasmin and matrix metalloproteinases by oleic acid and oleoyl-galardin derivative(s) Biochem Pharmacol (2011) 81, 626-635. PubMed Europe PubMed DOI I
Quillard,T., Tesmenitsky,Y., Croce,K., Travers,R., Shvartz,E., Koskinas,K.C., Sukhova,G.K., Aikawa,E., Aikawa,M. and Libby,P. Selective inhibition of matrix metalloproteinase-13 increases collagen content of established mouse atherosclerosis Arterioscler Thromb Vasc Biol (2011) 31, 2464-2472. PubMed Europe PubMed DOI I
Roth,J., Minond,D., Darout,E., Liu,Q., Lauer,J., Hodder,P., Fields,G.B. and Roush,W.R. Identification of novel, exosite-binding matrix metalloproteinase-13 inhibitor scaffolds Bioorg Med Chem Lett (2011) 21, 7180-7184. PubMed Europe PubMed DOI I
Ryu,J.H., Lee,A., Na,J.H., Lee,S., Ahn,H.J., Park,J.W., Ahn,C.H., Kim,B.S., Kwon,I.C., Choi,K., Youn,I. and Kim,K. Optimization of matrix metalloproteinase fluorogenic probes for osteoarthritis imaging Amino Acids (2011) 41, 1113-1122. PubMed Europe PubMed DOI A L
Taylor,S.J., Abeywardane,A., Liang,S., Muegge,I., Padyana,A.K., Xiong,Z., Hill-Drzewi,M., Farmer,B., Li,X., Collins,B., Li,J.X., Heim-Riether,A., Proudfoot,J., Zhang,Q., Goldberg,D., Zuvela-Jelaska,L., Zaher,H., Li,J. and Farrow,N.A. Fragment-based discovery of indole inhibitors of matrix metalloproteinase-13 J Med Chem (2011) 54, 8174-8187. PubMed Europe PubMed DOI I
Tommasi,R.A., Weiler,S., McQuire,L.W., Rogel,O., Chambers,M., Clark,K., Doughty,J., Fang,J., Ganu,V., Grob,J., Goldberg,R., Goldstein,R., Lavoie,S., Kulathila,R., Macchia,W., Melton,R., Springer,C., Walker,M., Zhang,J., Zhu,L. and Shultz,M. Potent and selective 2-naphthylsulfonamide substituted hydroxamic acid inhibitors of matrix metalloproteinase-13 Bioorg Med Chem Lett (2011) 21, 6440-6445. PubMed Europe PubMed DOI I
Vicini,P., Crasci,L., Incerti,M., Ronsisvalle,S., Cardile,V. and Panico,A.M. Benzisothiazolyliminothiazolidin-4-ones with chondroprotective properties: searching for potent and selective inhibitors of MMP-13 ChemMedChem (2011) 6, 1199-1202. PubMed Europe PubMed DOI I

2010

Becker,D.P., Barta,T.E., Bedell,L.J., Boehm,T.L., Bond,B.R., Carroll,J., Carron,C.P., Decrescenzo,G.A., Easton,A.M., Freskos,J.N., Funckes-Shippy,C.L., Heron,M., Hockerman,S., Howard,C.P., Kiefer,J.R., Li,M.H., Mathis,K.J., McDonald,J.J., Mehta,P.P., Munie,G.E., Sunyer,T., Swearingen,C.A., Villamil,C.I., Welsch,D., Williams,J.M., Yu,Y. and Yao,J. Orally active MMP-1 sparing alpha-tetrahydropyranyl and alpha-piperidinyl sulfone matrix metalloproteinase (MMP) inhibitors with efficacy in cancer, arthritis, and cardiovascular disease J Med Chem (2010) 53, 6653-6680. PubMed Europe PubMed DOI I
Borzi,R.M., Olivotto,E., Pagani,S., Vitellozzi,R., Neri,S., Battistelli,M., Falcieri,E., Facchini,A., Flamigni,F., Penzo,M., Platano,D., Santi,S., Facchini,A. and Marcu,K.B. Matrix metalloproteinase 13 loss associated with impaired extracellular matrix remodeling disrupts chondrocyte differentiation by concerted effects on multiple regulatory factors Arthritis Rheum (2010) 62, 2370-2381. PubMed Europe PubMed DOI K
Devel,L., Czarny,B., Beau,F., Georgiadis,D., Stura,E. and Dive,V. Third generation of matrix metalloprotease inhibitors: gain in selectivity by targeting the depth of the S1' cavity Biochimie (2010) 92, 1501-1508. PubMed Europe PubMed DOI I
Flechsig,P., Hartenstein,B., Teurich,S., Dadrich,M., Hauser,K., Abdollahi,A., Grone,H.J., Angel,P. and Huber,P.E. Loss of matrix metalloproteinase-13 attenuates murine radiation-induced pulmonary fibrosis Int J Radiat Oncol Biol Phys (2010) 77, 582-590. PubMed Europe PubMed DOI K T
Gao,D.A., Xiong,Z., Heim-Riether,A., Amodeo,L., August,E.M., Cao,X., Ciccarelli,L., Collins,B.K., Harrington,K., Haverty,K., Hill-Drzewi,M., Li,X., Liang,S., Margarit,S.M., Moss,N., Nagaraja,N., Proudfoot,J., Roman,R., Schlyer,S., Keenan,L.S., Taylor,S., Wellenzohn,B., Wiedenmayer,D., Li,J. and Farrow,N.A. SAR studies of non-zinc-chelating MMP-13 inhibitors: improving selectivity and metabolic stability Bioorg Med Chem Lett (2010) 20, 5039-5043. PubMed Europe PubMed DOI I
Inoue,A., Takahashi,H., Harada,H., Kohno,S., Ohue,S., Kobayashi,K., Yano,H., Tanaka,J. and Ohnishi,T. Cancer stem-like cells of glioblastoma characteristically express MMP-13 and display highly invasive activity Int J Oncol (2010) 37, 1121-1131. PubMed Europe PubMed DOI
Jiang,Y., Abernathy,J.W., Peatman,E., Liu,H., Wang,S., Xu,D.H., Kucuktas,H., Klesius,P. and Liu,Z. Identification and characterization of matrix metalloproteinase-13 sequence structure and expression during embryogenesis and infection in channel catfish (Ictalurus punctatus) Dev Comp Immunol (2010) 34, 590-597. PubMed Europe PubMed DOI
Jungel,A., Ospelt,C., Lesch,M., Thiel,M., Sunyer,T., Schorr,O., Michel,B.A., Gay,R.E., Kolling,C., Flory,C., Gay,S. and Neidhart,M. Effect of the oral application of a highly selective MMP-13 inhibitor in three different animal models of rheumatoid arthritis Ann Rheum Dis (2010) 69, 898-902. PubMed Europe PubMed DOI I
Kolodziej,S.A., Hockerman,S.L., Decrescenzo,G.A., McDonald,J.J., Mischke,D.A., Munie,G.E., Fletcher,T.R., Stehle,N., Swearingen,C. and Becker,D.P. MMP-13 selective isonipecotamide alpha-sulfone hydroxamates Bioorg Med Chem Lett (2010) 20, 3561-3564. PubMed Europe PubMed DOI I
Kothapalli,R., Khan,A.M., Basappa, Gopalsamy,A., Chong,Y.S. and Annamalai,L. Cheminformatics-based drug design approach for identification of inhibitors targeting the characteristic residues of MMP-13 hemopexin domain PLoS ONE (2010) 5, e12494-e12494. PubMed Europe PubMed DOI PMC EPMC I
Piecha,D., Weik,J., Kheil,H., Becher,G., Timmermann,A., Jaworski,A., Burger,M. and Hofmann,M.W. Novel selective MMP-13 inhibitors reduce collagen degradation in bovine articular and human osteoarthritis cartilage explants Inflamm Res (2010) 59, 379-389. PubMed Europe PubMed DOI I
Schnute,M.E., O'Brien,P.M., Nahra,J., Morris,M., Howard Roark,W., Hanau,C.E., Ruminski,P.G., Scholten,J.A., Fletcher,T.R., Hamper,B.C., Carroll,J.N., Patt,W.C., Shieh,H.S., Collins,B., Pavlovsky,A.G., Palmquist,K.E., Aston,K.W., Hitchcock,J., Rogers,M.D., McDonald,J., Johnson,A.R., Munie,G.E., Wittwer,A.J., Man,C.F., Settle,S.L., Nemirovskiy,O., Vickery,L.E., Agawal,A., Dyer,R.D. and Sunyer,T. Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis Bioorg Med Chem Lett (2010) 20, 576-580. PubMed Europe PubMed DOI I
Sen,A.I., Shiomi,T., Okada,Y. and D'Armiento,J.M. Deficiency of matrix metalloproteinase-13 increases inflammation after acute lung injury Exp Lung Res (2010) 36, 615-624. PubMed Europe PubMed DOI K
Settle,S., Vickery,L., Nemirovskiy,O., Vidmar,T., Bendele,A., Messing,D., Ruminski,P., Schnute,M. and Sunyer,T. Cartilage degradation biomarkers predict efficacy of a novel, highly selective matrix metalloproteinase 13 inhibitor in a dog model of osteoarthritis: confirmation by multivariate analysis that modulation of type II collagen and aggrecan degradation peptides parallels pathologic changes Arthritis Rheum (2010) 62, 3006-3015. PubMed Europe PubMed DOI I
Zhang,L., Yang,M., Yang,D., Cavey,G., Davidson,P. and Gibson,G. Molecular interactions of MMP-13 C-terminal domain with chondrocyte proteins Connect Tissue Res (2010) 51, 230-239. PubMed Europe PubMed DOI

2009

Baragi,V.M., Becher,G., Bendele,A.M., Biesinger,R., Bluhm,H., Boer,J., Deng,H., Dodd,R., Essers,M., Feuerstein,T., Gallagher,B.M., Jr., Gege,C., Hochgurtel,M., Hofmann,M., Jaworski,A., Jin,L., Kiely,A., Korniski,B., Kroth,H., Nix,D., Nolte,B., Piecha,D., Powers,T.S., Richter,F., Schneider,M., Steeneck,C., Sucholeiki,I., Taveras,A., Timmermann,A., Van Veldhuizen,J., Weik,J., Wu,X. and Xia,B. A new class of potent matrix metalloproteinase 13 inhibitors for potential treatment of osteoarthritis: evidence of histologic and clinical efficacy without musculoskeletal toxicity in rat models Arthritis Rheum (2009) 60, 2008-2018. PubMed Europe PubMed DOI I
Carrascal,N. and Rizzo,R.C. Calculation of binding free energies for non-zinc chelating pyrimidine dicarboxamide inhibitors with MMP-13 Bioorg Med Chem Lett (2009) 19, 47-50. PubMed Europe PubMed DOI PMC EPMC I
Guo,A., Yang,L. and Gu,J.C. Membrane type-1 metalloproteinase mediates nitric oxide-induced activation of matrix metalloproteinase-13 Orthopedics (2009) 32, 826-826. PubMed Europe PubMed DOI
Hattori,N., Mochizuki,S., Kishi,K., Nakajima,T., Takaishi,H., D'Armiento,J. and Okada,Y. MMP-13 plays a role in keratinocyte migration, angiogenesis, and contraction in mouse skin wound healing Am J Pathol (2009) 175, 533-546. PubMed Europe PubMed DOI PMC EPMC K
Heim-Riether,A., Taylor,S.J., Liang,S., Gao,D.A., Xiong,Z., Michael August,E., Collins,B.K., Farmer,B.T., Haverty,K., Hill-Drzewi,M., Junker,H.D., Mariana Margarit,S., Moss,N., Neumann,T., Proudfoot,J.R., Keenan,L.S., Sekul,R., Zhang,Q., Li,J. and Farrow,N.A. Improving potency and selectivity of a new class of non-Zn-chelating MMP-13 inhibitors Bioorg Med Chem Lett (2009) 19, 5321-5324. PubMed Europe PubMed DOI I
Hernández,R.M., Sorsa,T., Obregón,F., Tervahartiala,T., Valenzuela,M.A., zo,P., tzan,N., saffre,E., las,M. and monal,J. Proteolytic roles of matrix metalloproteinase (MMP)-13 during progression of chronic periodontitis: initial evidence for MMP-13/MMP-9 activation cascade J Clin Periodontol (2009) 36, 1011-1017. PubMed Europe PubMed I
Kulkarni,G.B., Siva Reddy,A., Ramadevi,K., Kezia,D. and Narasimha Rao,M. 3D-QSAR studies of matrix metalloproteinase-13 inhibitors Rasayan J Chem (2009) 2, 407-414. I
Lauer-Fields,J.L., Minond,D., Chase,P.S., Baillargeon,P.E., Saldanha,S.A., Stawikowska,R., Hodder,P. and Fields,G.B. High throughput screening of potentially selective MMP-13 exosite inhibitors utilizing a triple-helical FRET substrate Bioorg Med Chem (2009) 17, 990-1005. PubMed Europe PubMed DOI I
Lausch,E., Keppler,R., Hilbert,K., Cormier-Daire,V., Nikkel,S., Nishimura,G., Unger,S., Spranger,J., Superti-Furga,A. and Zabel,B. Mutations in MMP9 and MMP13 determine the mode of inheritance and the clinical spectrum of metaphyseal anadysplasia Am J Hum Genet (2009) 85, 168-178. PubMed Europe PubMed
Lee,E.R., Lamplugh,L., Kluczyk,B., Leblond,C.P. and Mort,J.S. Neoepitopes reveal the features of type II collagen cleavage and the identity of a collagenase involved in the transformation of the epiphyses anlagen in development Dev Dyn (2009) 238, 1547-1563. PubMed Europe PubMed DOI
Li,W., Hu,Y., Li,J., Thomason,J.R., DeVincentis,D., Du,X., Wu,J., Hotchandani,R., Rush,T.S., III, Skotnicki,J.S., Tam,S., Chockalingam,P.S., Morris,E.A. and Levin,J.I. 3,4-Disubstituted benzofuran P1' MMP-13 inhibitors: optimization of selectivity and reduction of protein binding Bioorg Med Chem Lett (2009) 19, 4546-4550. PubMed Europe PubMed DOI I
Little,C.B., Barai,A., Burkhardt,D., Smith,S.M., Fosang,A.J., Werb,Z., Shah,M. and Thompson,E.W. Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development Arthritis Rheum (2009) 60, 3723-3733. PubMed Europe PubMed DOI K
Monovich,L.G., Tommasi,R.A., Fujimoto,R.A., Blancuzzi,V., Clark,K., Cornell,W.D., Doti,R., Doughty,J., Fang,J., Farley,D., Fitt,J., Ganu,V., Goldberg,R., Goldstein,R., Lavoie,S., Kulathila,R., Macchia,W., Parker,D.T., Melton,R., O'Byrne,E., Pastor,G., Pellas,T., Quadros,E., Reel,N., Roland,D.M., Sakane,Y., Singh,H., Skiles,J., Somers,J., Toscano,K., Wigg,A., Zhou,S., Zhu,L., Shieh,W.C., Xue,S. and McQuire,L.W. Discovery of potent, selective, and orally active carboxylic acid based inhibitors of matrix metalloproteinase-13 J Med Chem (2009) 52, 3523-3538. PubMed Europe PubMed DOI I
Nuti,E., Casalini,F., Avramova,S.I., Santamaria,S., Cercignani,G., Marinelli,L., La Pietra,V., Novellino,E., Orlandini,E., Nencetti,S., Tuccinardi,T., Martinelli,A., Lim,N.H., Visse,R., Nagase,H. and Rossello,A. N-O-Isopropyl sulfonamido-based hydroxamates: design, synthesis and biological evaluation of selective matrix metalloproteinase-13 inhibitors as potential therapeutic agents for osteoarthritis J Med Chem (2009) 52, 4757-4773. PubMed Europe PubMed DOI I
Yeh,W.L., Lu,D.Y., Lee,M.J. and Fu,W.M. Leptin induces migration and invasion of glioma cells through MMP-13 production Glia (2009) 57, 454-464. PubMed Europe PubMed DOI
Zigrino,P., Kuhn,I., Bauerle,T., Zamek,J., Fox,J.W., Neumann,S., Licht,A., Schorpp-Kistner,M., Angel,P. and Mauch,C. Stromal expression of MMP-13 is required for melanoma invasion and metastasis J Invest Dermatol (2009) 129, 2686-2693. PubMed Europe PubMed DOI T

2008

Gooljarsingh,L.T., Lakdawala,A., Coppo,F., Luo,L., Fields,G.B., Tummino,P.J. and Gontarek,R.R. Characterization of an exosite binding inhibitor of matrix metalloproteinase 13 Protein Sci (2008) 17, 66-71. PubMed Europe PubMed DOI PMC EPMC I
Lee,S., Park,K., Lee,S.Y., Ryu,J.H., Park,J.W., Ahn,H.J., Kwon,I.C., Youn,I.C., Kim,K. and Choi,K. Dark quenched matrix metalloproteinase fluorogenic probe for imaging osteoarthritis development in vivo Bioconjug Chem (2008) 19, 1743-1747. PubMed Europe PubMed DOI L
Li,J.J., Nahra,J., Johnson,A.R., Bunker,A., O'Brien,P., Yue,W.S., Ortwine,D.F., Man,C.F., Baragi,V., Kilgore,K., Dyer,R.D. and Han,H.K. Quinazolinones and pyrido[3,4-d]pyrimidin-4-ones as orally active and specific matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis J Med Chem (2008) 51, 835-841. PubMed Europe PubMed DOI I
Monfort,J., Tardif,G., Roughley,P., Reboul,P., Boileau,C., Bishop,P.N., Pelletier,J.P. and Martel-Pelletier,J. Identification of opticin, a member of the small leucine-rich repeat proteoglycan family, in human articular tissues: a novel target for MMP-13 in osteoarthritis Osteoarthritis Cartilage (2008) 16, 749-755. PubMed Europe PubMed DOI
Yiotakis,A. and Dive,V. Synthetic active site-directed inhibitors of metzincins: achievement and perspectives Mol Aspects Med (2008) 29, 329-338. PubMed Europe PubMed DOI I
Yiotakis,A. and Dive,V. Third-generation MMP inhibitors: Recent advances in the development of highly selective inhibitors The Cancer Degradome: Proteases and Cancer Biol (2008) , 811-825. DOI I
Zhang,Y., Bai,X.T., Zhu,K.Y., Jin,Y., Deng,M., Le,H.Y., Fu,Y.F., Chen,Y., Zhu,J., Look,A.T., Kanki,J., Chen,Z., Chen,S.J. and Liu,T.X. In vivo interstitial migration of primitive macrophages mediated by JNK-matrix metalloproteinase 13 signaling in response to acute injury J Immunol (2008) 181, 2155-2164. PubMed Europe PubMed

2007

Danfelter,M., Onnerfjord,P. and Heinegard,D. Fragmentation of proteins in cartilage treated with interleukin-1: specific cleavage of type IX collagen by matrix metalloproteinase 13 releases the NC4 domain J Biol Chem (2007) 282, 36933-36941. PubMed Europe PubMed DOI P
Freeman-Cook,K.D., Reiter,L.A., Noe,M.C., Antipas,A.S., Danley,D.E., Datta,K., Downs,J.T., Eisenbeis,S., Eskra,J.D., Garmene,D.J., Greer,E.M., Griffiths,R.J., Guzman,R., Hardink,J.R., Janat,F., Jones,C.S., Martinelli,G.J., Mitchell,P.G., Laird,E.R., Liras,J.L., Lopresti-Morrow,L.L., Pandit,J., Reilly,U.D., Robertson,D., Vaughn-Bowser,M.L., Wolf-Gouviea,L.A. and Yocum,S.A. Potent, selective spiropyrrolidine pyrimidinetrione inhibitors of MMP-13 Bioorg Med Chem Lett (2007) 17, 6529-6534. PubMed Europe PubMed DOI I
Hillegass,J.M., Villano,C.M., Cooper,K.R. and White,L.A. Matrix metalloproteinase-13 is required for zebrafish (Danio rerio) development and is a target for glucocorticoids Toxicol Sci (2007) 100, 168-179. PubMed Europe PubMed DOI
Iliopoulos,D., Malizos,K.N. and Tsezou,A. Epigenetic regulation of leptin affects MMP-13 expression in osteoarthritic chondrocytes: possible molecular target for osteoarthritis therapeutic intervention Ann Rheum Dis (2007) 66, 1616-1621. PubMed Europe PubMed DOI
Johnson,A.R., Pavlovsky,A.G., Ortwine,D.F., Prior,F., Man,C.F., Bornemeier,D.A., Banotai,C.A., Mueller,W.T., McConnell,P., Yan,C., Baragi,V., Lesch,C., Roark,W.H., Wilson,M., Datta,K., Guzman,R., Han,H.K. and Dyer,R.D. Discovery and characterization of a novel inhibitor of matrix metalloprotease-13 that reduces cartilage damage in vivo without joint fibroplasia side effects J Biol Chem (2007) 282, 27781-27791. PubMed Europe PubMed DOI S I
[YEAR:23-3-2007]Kosaki,N., Takaishi,H., Kamekura,S., Kimura,T., Okada,Y., Minqi,L., Amizuka,N., Chung,U.I., Nakamura,K., Kawaguchi,H., Toyama,Y. and D'Armiento,J. Impaired bone fracture healing in matrix metalloproteinase-13 deficient mice Biochem Biophys Res Commun (23-3-2007) 354, 846-851. PubMed Europe PubMed DOI K
Maskos,K., Lang,R., Tschesche,H. and Bode,W. Flexibility and variability of TIMP binding: X-ray structure of the complex between collagenase-3/MMP-13 and TIMP-2 J Mol Biol (2007) 366, 1222-1231. PubMed Europe PubMed DOI S
Samuel,S., Beifuss,K.K. and Bernstein,L.R. YB-1 binds to the MMP-13 promoter sequence and represses MMP-13 transactivation via the AP-1 site Biochim Biophys Acta (2007) 1769, 525-531. PubMed Europe PubMed DOI PMC EPMC
Toriseva,M.J., Ala-aho,R., Karvinen,J., Baker,A.H., Marjomaki,V.S., Heino,J. and Kahari,V.M. Collagenase-3 (MMP-13) enhances remodeling of three-dimensional collagen and promotes survival of human skin fibroblasts J Invest Dermatol (2007) 127, 49-59. PubMed Europe PubMed DOI

2006

Hernandez,M., Valenzuela,M.A., Lopez-Otin,C., Alvarez,J., Lopez,J.M., Vernal,R. and Gamonal,J. Matrix metalloproteinase-13 is highly expressed in destructive periodontal disease activity J Periodontol (2006) 77, 1863-1870. PubMed Europe PubMed DOI
[YEAR:27-3-2006]Kohno,T., Hochigai,H., Yamashita,E., Tsukihara,T. and Kanaoka,M. Crystal structures of the catalytic domain of human stromelysin-1 (MMP-3) and collagenase-3 (MMP-13) with a hydroxamic acid inhibitor SM-25453 Biochem Biophys Res Commun (27-3-2006) 344, 315-322. PubMed Europe PubMed DOI S I
Minond,D., Lauer-Fields,J.L., Cudic,M., Overall,C.M., Pei,D., Brew,K., Visse,R., Nagase,H. and Fields,G.B. The roles of substrate thermal stability and P2 and P1' subsite identity on matrix metalloproteinase triple-helical peptidase activity and collagen specificity J Biol Chem (2006) 281, 38302-38313. PubMed Europe PubMed DOI
Monfort,J., Tardif,G., Reboul,P., Mineau,F., Roughley,P., Pelletier,J.P. and Martel-Pelletier,J. Degradation of small leucine-rich repeat proteoglycans by matrix metalloprotease-13: identification of a new biglycan cleavage site Arthritis Res Ther (2006) 8, R26-R26. PubMed Europe PubMed DOI PMC EPMC

2005

[YEAR:1-4-2005]Blagg,J.A., Noe,M.C., Wolf-Gouveia,L.A., Reiter,L.A., Laird,E.R., Chang,S.P., Danley,D.E., Downs,J.T., Elliott,N.C., Eskra,J.D., Griffiths,R.J., Hardink,J.R., Haugeto,A.I., Jones,C.S., Liras,J.L., Lopresti-Morrow,L.L., Mitchell,P.G., Pandit,J., Robinson,R.P., Subramanyam,C., Vaughn-Bowser,M.L. and Yocum,S.A. Potent pyrimidinetrione-based inhibitors of MMP-13 with enhanced selectivity over MMP-14 Bioorg Med Chem Lett (1-4-2005) 15, 1807-1810. PubMed Europe PubMed DOI I
Engel,C.K., Pirard,B., Schimanski,S., Kirsch,R., Habermann,J., Klingler,O., Schlotte,V., Weithmann,K.U. and Wendt,K.U. Structural basis for the highly selective inhibition of MMP-13 Chem Biol (2005) 12, 181-189. PubMed Europe PubMed DOI I
[YEAR:15-9-2005]Kennedy,A.M., Inada,M., Krane,S.M., Christie,P.T., Harding,B., Lopez-Otin,C., Sanchez,L.M., Pannett,A.A., Dearlove,A., Hartley,C., Byrne,M.H., Reed,A.A., Nesbit,M.A., Whyte,M.P. and Thakker,R.V. MMP13 mutation causes spondyloepimetaphyseal dysplasia, Missouri type (SEMDMO) J Clin Invest (15-9-2005) 115, 2832-2842. PubMed Europe PubMed DOI PMC EPMC M
[YEAR:15-2-2005]Kim,S.H., Pudzianowski,A.T., Leavitt,K.J., Barbosa,J., McDonnell,P.A., Metzler,W.J., Rankin,B.M., Liu,R., Vaccaro,W. and Pitts,W. Structure-based design of potent and selective inhibitors of collagenase-3 (MMP-13) Bioorg Med Chem Lett (15-2-2005) 15, 1101-1106. PubMed Europe PubMed DOI I
[YEAR:6-9-2005]Li,J., Rush,T.S., III, Li,W., DeVincentis,D., Du,X., Hu,Y., Thomason,J.R., Xiang,J.S., Skotnicki,J.S., Tam,S., Cunningham,K.M., Chockalingam,P.S., Morris,E.A. and Levin,J.I. Synthesis and SAR of highly selective MMP-13 inhibitors Bioorg Med Chem Lett (6-9-2005) 15, 4961-4966. PubMed Europe PubMed DOI I
[YEAR:8-3-2005]Lopez-Rivera,E., Lizarbe,T.R., Martinez-Moreno,M., Lopez-Novoa,J.M., Rodriguez-Barbero,A., Rodrigo,J., Fernandez,A.P., Alvarez-Barrientos,A., Lamas,S. and Zaragoza,C. Matrix metalloproteinase 13 mediates nitric oxide activation of endothelial cell migration Proc Natl Acad Sci U S A (8-3-2005) 102, 3685-3690. PubMed Europe PubMed DOI PMC EPMC
[YEAR:2-6-2005]Noe,M.C., Natarajan,V., Snow,S.L., Mitchell,P.G., Lopresti-Morrow,L., Reeves,L.M., Yocum,S.A., Carty,T.J., Barberia,J.A., Sweeney,F.J., Liras,J.L., Vaughn,M., Hardink,J.R., Hawkins,J.M. and Tokar,C. Discovery of 3,3-dimethyl-5-hydroxypipecolic hydroxamate-based inhibitors of aggrecanase and MMP-13 Bioorg Med Chem Lett (2-6-2005) 15, 2808-2811. PubMed Europe PubMed DOI I
[YEAR:15-7-2005]Noe,M.C., Natarajan,V., Snow,S.L., Wolf-Gouveia,L.A., Mitchell,P.G., Lopresti-Morrow,L., Reeves,L.M., Yocum,S.A., Otterness,I., Bliven,M.A., Carty,T.J., Barberia,J.T., Sweeney,F.J., Liras,J.L. and Vaughn,M. Discovery of 3-OH-3-methylpipecolic hydroxamates: potent orally active inhibitors of aggrecanase and MMP-13 Bioorg Med Chem Lett (15-7-2005) 15, 3385-3388. PubMed Europe PubMed DOI I
Wasserman,Z.R. Making a new turn in matrix metalloprotease inhibition Chem Biol (2005) 12, 143-144. PubMed Europe PubMed DOI S I
[YEAR:5-7-2005]Wu,J., Rush,T.S., III, Hotchandani,R., Du,X., Geck,M., Collins,E., Xu,Z.B., Skotnicki,J., Levin,J.I. and Lovering,F.E. Identification of potent and selective MMP-13 inhibitors Bioorg Med Chem Lett (5-7-2005) 15, 4105-4109. PubMed Europe PubMed DOI I

2004

[YEAR:19-4-2004]Ala-aho,R., Ahonen,M., George,S.J., Heikkila,J., Grenman,R., Kallajoki,M. and Kahari,V.M. Targeted inhibition of human collagenase-3 (MMP-13) expression inhibits squamous cell carcinoma growth in vivo Oncogene (19-4-2004) 23, 5111-5123. PubMed Europe PubMed DOI
Henriet,P. and Eeckhout,Y. Collagenase 3 [ISSN:0-12-079610-4] (2004) 2, 486-494. V
[YEAR:7-12-2004]Inada,M., Wang,Y., Byrne,M.H., Rahman,M.U., Miyaura,C., Lopez-Otin,C. and Krane,S.M. Critical roles for collagenase-3 (Mmp13) in development of growth plate cartilage and in endochondral ossification Proc Natl Acad Sci U S A (7-12-2004) 101, 17192-17197. PubMed Europe PubMed DOI PMC EPMC K
Joronen,K., Ala-aho,R., Majuri,M.L., Alenius,H., Kahari,V.M. and Vuorio,E. Adenovirus mediated intra-articular expression of collagenase-3 (MMP-13) induces inflammatory arthritis in mice Ann Rheum Dis (2004) 63, 656-664. PubMed Europe PubMed DOI PMC EPMC
[YEAR:20-9-2004]Noe,M.C., Snow,S.L., Wolf-Gouveia,L.A., Mitchell,P.G., Lopresti-Morrow,L., Reeves,L.M., Yocum,S.A., Liras,J.L. and Vaughn,M. 3-Hydroxy-4-arylsulfonyltetrahydropyranyl-3-hydroxamic acids are novel inhibitors of MMP-13 and aggrecanase Bioorg Med Chem Lett (20-9-2004) 14, 4727-4730. PubMed Europe PubMed DOI I
Stickens,D., Behonick,D.J., Ortega,N., Heyer,B., Hartenstein,B., Yu,Y., Fosang,A.J., Schorpp-Kistner,M., Angel,P. and Werb,Z. Altered endochondral bone development in matrix metalloproteinase 13-deficient mice Development (2004) 131, 5883-5895. PubMed Europe PubMed DOI PMC EPMC K
Tardif,G., Reboul,P., Pelletier,J.P. and Martel-Pelletier,J. Ten years in the life of an enzyme: the story of the human MMP-13 (collagenase-3) Mod Rheumatol (2004) 14, 197-204. PubMed Europe PubMed DOI V
[YEAR:5-4-2004]Zijlstra,A., Aimes,R.T., Zhu,D., Regazzoni,K., Kupriyanova,T., Seandel,M., Deryugina,E.I. and Quigley,J.P. Collagenolysis-dependent angiogenesis mediated by matrix metalloproteinase-13 (collagenase-3) J Biol Chem (5-4-2004) 279, 27633-27645. PubMed Europe PubMed DOI

2003

Skotnicki,J.S., DiGrandi,M.J. and Levin,J.I. Design strategies for the identification of MMP-13 and TACE inhibitors Curr Opin Drug Discov Devel (2003) 6, 742-759. PubMed Europe PubMed I
Tardif,G., Dupuis,M., Reboul,P., Geng,C.S., Pelletier,J.P., Ranger,P. and Martel-Pelletier,J. Identification and differential expression of human collagenase-3 mRNA species derived from internal deletion, alternative splicing, and different polyadenylation and transcription initiation sites Osteoarthritis Cartilage (2003) 11, 524-537. PubMed Europe PubMed DOI R

2002

[YEAR:20-1-2002]Ala-aho,R., Johansson,N., Baker,A.H. and Kahari,V.M. Expression of collagenase-3 (MMP-13) enhances invasion of human fibrosarcoma HT-1080 cells Int J Cancer (20-1-2002) 97, 283-289. PubMed Europe PubMed DOI I
[YEAR:20-3-2002]Campbell,S.E., Sood,A., Argyle,D.J., Nasir,L., Argyle,S.A. and Bennett,D. The cloning and functional analysis of canine matrix metalloproteinase-13 gene promoter Gene (20-3-2002) 286, 233-240. PubMed Europe PubMed DOI
Fukui,N., McAlinden,A., Zhu,Y., Crouch,E., Broekelmann,T.J., Mecham,R.P. and Sandell,L.J. Processing of type II procollagen amino propeptide by matrix metalloproteinases J Biol Chem (2002) 277, 2193-2201. PubMed Europe PubMed DOI
[YEAR:4-12-2002]Knauper,V., Bailey,L., Worley,J.R., Soloway,P., Patterson,M.L. and Murphy,G. Cellular activation of proMMP-13 by MT1-MMP depends on the C-terminal domain of MMP-13 FEBS Lett (4-12-2002) 532, 127-130. PubMed Europe PubMed DOI
Leeman,M.F., Curran,S. and Murray,G.I. The structure, regulation, and function of human matrix metalloproteinase-13 Crit Rev Biochem Mol Biol (2002) 37, 149-166. PubMed Europe PubMed DOI
Murphy,G., Knauper,V., Atkinson,S., Butler,G., English,W., Hutton,M., Stracke,J. and Clark,I. Matrix metalloproteinases in arthritic disease Arthritis Res (2002) 4 Suppl 3, S39-S49. PubMed Europe PubMed
Wu,C.W., Tchetina,E.V., Mwale,F., Hasty,K., Pidoux,I., Reiner,A., Chen,J., Van Wart,H.E. and Poole,A.R. Proteolysis involving matrix metalloproteinase 13 (collagenase-3) is required for chondrocyte differentiation that is associated with matrix mineralization J Bone Miner Res (2002) 17, 639-651. PubMed Europe PubMed DOI

2001

[YEAR:6-4-2001]D'Angelo,M., Billings,P.C., Pacifici,M., Leboy,P.S. and Kirsch,T. Authentic matrix vesicles contain active metalloproteases (MMP). A role for matrix vesicle-associated MMP-13 in activation of transforming growth factor-beta J Biol Chem (6-4-2001) 276, 11347-11353. PubMed Europe PubMed DOI
Natchus,M.G., Bookland,R.G., Laufersweiler,M.J., Pikul,S., Almstead,N.G., De,B., Janusz,M.J., Hsieh,L.C., Gu,F., Pokross,M.E., Patel,V.S., Garver,S.M., Peng,S.X., Branch,T.M., King,S.L., Baker,T.R., Foltz,D.J. and Mieling,G.E. Development of new carboxylic acid-based MMP inhibitors derived from functionalized propargylglycines J Med Chem (2001) 44, 1060-1071. PubMed Europe PubMed DOI I
Neuhold,L.A., Killar,L., Zhao,W., Sung,M.L., Warner,L., Kulik,J., Turner,J., Wu,W., Billinghurst,C., Meijers,T., Poole,A.R., Babij,P. and DeGennaro,L.J. Postnatal expression in hyaline cartilage of constitutively active human collagenase-3 (MMP-13) induces osteoarthritis in mice J Clin Invest (2001) 107, 35-44. PubMed Europe PubMed DOI PMC EPMC
[YEAR:1-6-2001]Yu,W.H. and Woessner,J.F., Jr. Heparin-enhanced zymographic detection of matrilysin and collagenases Anal Biochem (1-6-2001) 293, 38-42. PubMed Europe PubMed DOI A L

2000

[YEAR:6-10-2000]Deng,S.J., Bickett,D.M., Mitchell,J.L., Lambert,M.H., Blackburn,R.K., Carter,H.L., III, Neugebauer,J., Pahel,G., Weiner,M.P. and Moss,M.L. Substrate specificity of human collagenase 3 assessed using a phage-displayed peptide library J Biol Chem (6-10-2000) 275, 31422-31427. PubMed Europe PubMed DOI P
Hardern,I.M., Knauper,V., Ernill,R.J., Taylor,I.W.F., Cooper,K.L. and Abbott,W.M. An analysis of two refolding routes for a C-terminally truncated human collagenase-3 expressed in Escherichia coli Protein Expr Purif (2000) 19, 246-252. PubMed Europe PubMed DOI E
[YEAR:22-9-2000]Moy,F.J., Chanda,P.K., Chen,J.M., Cosmi,S., Edris,W., Levin,J.I. and Powers,R. High-resolution solution structure of the catalytic fragment of human collagenase-3 (MMP-13) complexed with a hydroxamic acid inhibitor J Mol Biol (22-9-2000) 302, 671-689. PubMed Europe PubMed DOI S I
Otterness,I.G., Bliven,M.L., Eskra,J.D., te Koppele,J.M., Stukenbrok,H.A. and Milici,A.J. Cartilage damage after intraarticular exposure to collagenase 3 Osteoarthritis Cartilage (2000) 8, 366-373. PubMed Europe PubMed DOI
[YEAR:15-2-2000]Pendas,A.M., Uria,J.A., Jimenez,M.G., Balbin,M., Freije,J.P. and Lopez-Otin,C. An overview of collagenase-3 expression in malignant tumors and analysis of its potential value as a target in antitumor therapies Clin Chim Acta (15-2-2000) 291, 137-155. PubMed Europe PubMed DOI
[YEAR:11-8-2000]Zhang,X., Gonnella,N.C., Koehn,J., Pathak,N., Ganu,V., Melton,R., Parker,D., Hu,S.I. and Nam,K.Y. Solution structure of the catalytic domain of human collagenase-3 (MMP-13) complexed to a potent non-peptidic sulfonamide inhibitor: Binding comparison with stromelysin-1 and collagenase-1 J Mol Biol (11-8-2000) 301, 513-524. PubMed Europe PubMed DOI S I

1999

[YEAR:1-10-1999]Botos,I., Meyer,E., Swanson,S.M., Lemaitre,V., Eeckhout,Y. and Meyer,E.F. Structure of recombinant mouse collagenase-3 (MMP-13) J Mol Biol (1-10-1999) 292, 837-844. PubMed Europe PubMed DOI S
Jimenez,M.J., Balbin,M., Lopez,J.M., Alvarez,J., Komori,T. and Lopez-Otin,C. Collagenase 3 is a target of Cbfa1, a transcription factor of the runt gene family involved in bone formation Mol Cell Biol (1999) 19, 4431-4442. PubMed Europe PubMed PMC EPMC
Johansson,N., Vaalamo,M., Grenman,S., Hietanen,S., Klemi,P., Saarialho-Kere,U. and Kahari,V.M. Collagenase-3 (MMP-13) is expressed by tumor cells in invasive vulvar squamous cell carcinomas Am J Pathol (1999) 154, 469-480. PubMed Europe PubMed DOI PMC EPMC
Lovejoy,B., Welch,A.R., Carr,S., Luong,C., Broka,C., Hendricks,R.T., Campbell,J.A., Walker,K.A., Martin,R., Van Wart,H. and Browner,M.F. Crystal structures of MMP-1 and -13 reveal the structural basis for selectivity of collagenase inhibitors Nat Struct Biol (1999) 6, 217-221. PubMed Europe PubMed DOI S I

1998

Kozaci,L.D., Brown,C.J., Adcocks,C., Galloway,A., Hollander,A.P. and Buttle,D.J. Stromelysin 1, neutrophil collagenase, and collagenase 3 do not play major roles in a model of chondrocyte mediated cartilage breakdown J Clin Pathol Mol Pathol (1998) 51, 282-286. PubMed Europe PubMed
Pathak,N., Hu,S.I. and Koehn,J.A. The expression, refolding, and purification of the catalytic domain of human collagenase-3 (MMP-13) Protein Expr Purif (1998) 14, 283-288. PubMed Europe PubMed DOI
[YEAR:24-4-1998]Selvamurugan,N., Chou,W.Y., Pearman,A.T., Pulumati,M.R. and Partridge,N.C. Parathyroid hormone regulates the rat collagenase-3 promoter in osteoblastic cells through the cooperative interaction of the activator protein-1 site and the runt domain binding sequence J Biol Chem (24-4-1998) 273, 10647-10657. PubMed Europe PubMed DOI
Uitto,V.J., Airola,K., Vaalamo,M., Johansson,N., Putnins,E.E., Firth,J.D., Salonen,J., Lopez-Otin,C., Saarialho-Kere,U. and Kahari,V.M. Collagenase-3 (matrix metalloproteinase-13) expression is induced in oral mucosal epithelium during chronic inflammation Am J Pathol (1998) 152, 1489-1499. PubMed Europe PubMed PMC EPMC
[YEAR:17-4-1998]Uria,J.A., Jimenez,M.G., Balbin,M., Freije,J.M. and Lopez-Otin,C. Differential effects of transforming growth factor-beta on the expression of collagenase-1 and collagenase-3 in human fibroblasts J Biol Chem (17-4-1998) 273, 9769-9777. PubMed Europe PubMed DOI
[YEAR:1-4-1998]Vincenti,M.P., Coon,C.I., Mengshol,J.A., Yocum,S., Mitchell,P. and Brinckerhoff,C.E. Cloning of the gene for interstitial collagenase-3 (matrix metalloproteinase-13) from rabbit synovial fibroblasts: differential expression with collagenase-1 (matrix metalloproteinase-1) Biochem J (1-4-1998) 331, 341-346. PubMed Europe PubMed PMC EPMC
Willmroth,F., Peter,H.H. and Conca,W. A matrix metalloproteinase gene expressed in human T lymphocytes is identical with collagenase 3 from breast carcinomas Immunobiology (1998) 198, 375-384. PubMed Europe PubMed DOI

1997

Airola,K., Johansson,N., Kariniemi,A.L., Kahari,V.M. and Saarialho-Kere,U.K. Human collagenase-3 is expressed in malignant squamous epithelium of the skin J Invest Dermatol (1997) 109, 225-231. PubMed Europe PubMed
Johansson,N., Saarialho-Kere,U., Airola,K., Herva,R., Nissinen,L., Westermarck,J., Vuorio,E., Heino,J. and Kahari,V.M. Collagenase-3 (MMP-13) is expressed by hypertrophic chondrocytes, periosteal cells, and osteoblasts during human fetal bone development Dev Dyn (1997) 208, 387-397. PubMed Europe PubMed DOI
Knauper,V., Cowell,S., Smith,B., Lopez-Otin,C., O'Shea,M., Morris,H., Zardi,L. and Murphy,G. The role of the C-terminal domain of human collagenase-3 (MMP-13) in the activation of procollagenase-3, substrate specificity, and tissue inhibitor of metalloproteinase interaction J Biol Chem (1997) 272, 7608-7616. PubMed Europe PubMed DOI
Knauper,V., Smith,B., Lopez-Otin,C. and Murphy,G. Activation of progelatinase B (proMMP-9) by active collagenase-3 (MMP-13) Eur J Biochem (1997) 248, 369-373. PubMed Europe PubMed
Lemaitre,V., Jungbluth,A. and Eeckhout,Y. The recombinant catalytic domain of mouse collagenase-3 depolymerizes type I collagen by cleaving its aminotelopeptides Biochem Biophys Res Commun (1997) 230, 202-205. PubMed Europe PubMed DOI

1996

Gomis-Ruth,F.X., Gohlke,U., Betz,M., Knauper,V., Murphy,G., Lopez-Otin,C. and Bode,W. The helping hand of collagenase-3 (MMP-13): 2.7 A crystal structure of its C-terminal haemopexin-like domain J Mol Biol (1996) 264, 556-566. PubMed Europe PubMed DOI
Knauper,V., Lopez-Otin,C., Smith,B., Knight,G. and Murphy,G. Biochemical characterization of human collagenase-3 J Biol Chem (1996) 271, 1544-1550. PubMed Europe PubMed DOI
Knauper,V., Will,H., Lopez-Otin,C., Smith,B., Atkinson,S.J., Stanton,H., Hembry,R.M. and Murphy,G. Cellular mechanisms for human procollagenase-3 (MMP-13) activation. Evidence that MT1-MMP (MMP-14) and gelatinase A (MMP-2) are able to generate active enzyme J Biol Chem (1996) 271, 17124-17131. PubMed Europe PubMed DOI
[YEAR:8-11-1996]Krane,S.M., Byrne,M.H., Lemaitre,V., Henriet,P., Jeffrey,J.J., Witter,J.P., Liu,X., Wu,H., Jaenisch,R. and Eeckhout,Y. Different collagenase gene products have different roles in degradation of type I collagen J Biol Chem (8-11-1996) 271, 28509-28515. PubMed Europe PubMed DOI
Mitchell,P.G., Magna,H.A., Reeves,L.M., Lopresti-Morrow,L.L., Yocum,S.A., Rosner,P.J., Geoghegan,K.F. and Hambor,J.E. Cloning, expression, and type II collagenolytic activity of matrix metalloproteinase-13 from human osteoarthritic cartilage J Clin Invest (1996) 97, 761-768. PubMed Europe PubMed DOI PMC EPMC
Reboul,P., Pelletier,J.P., Tardif,G., Cloutier,J.M. and Martel-Pelletier,J. The new collagenase, collagenase-3, is expressed and synthesized by human chondrocytes but not by synoviocytes. A role in osteoarthritis J Clin Invest (1996) 97, 2011-2019. PubMed Europe PubMed DOI PMC EPMC

1995

Pendas,A.M., Matilla,T., Estivill,X. and Lopez-Otin,C. The human collagenase-3 (CLG3) gene is located on chromosome 11q22.3 clustered to other members of the matrix metalloproteinase gene family Genomics (1995) 26, 615-618. PubMed Europe PubMed DOI

1994

[YEAR:17-6-1994]Freije,J.M., Diez-Itza,I., Balbin,M., Sanchez,L.M., Blasco,R., Tolivia,J. and Lopez-Otin,C. Molecular cloning and expression of collagenase-3, a novel human matrix metalloproteinase produced by breast carcinomas J Biol Chem (17-6-1994) 269, 16766-16773. PubMed Europe PubMed

1992

Henriet,P., Rousseau,G.G. and Eeckhout,Y. Cloning and sequencing of mouse collagenase cDNA. Divergence of mouse and rat collagenases from the other mammalian collagenases FEBS Lett (1992) 310, 175-178. PubMed Europe PubMed DOI

1990

Quinn,C.O., Scott,D.K., Brinckerhoff,C.E., Matrisian,L.M., Jeffrey,J.J. and Partridge,N.C. Rat collagenase. Cloning, amino acid sequence comparison, and parathyroid hormone regulation in osteoblastic cells J Biol Chem (1990) 265, 22342-22347. PubMed Europe PubMed

1985

Welgus,H.G., Grant,G.A., Sacchettini,J.C., Roswit,W.T. and Jeffrey,J.J. The gelatinolytic activity of rat uterus collagenase J Biol Chem (1985) 260, 13601-13606. PubMed Europe PubMed

1983

[YEAR:10-12-1983]Welgus,H.G., Kobayashi,D.K. and Jeffrey,J.J. The collagen substrate specificity of rat uterus collagenase J Biol Chem (10-12-1983) 258, 14162-14165. PubMed Europe PubMed